CN107374688A - Plugging device in a kind of tube chamber - Google Patents
Plugging device in a kind of tube chamber Download PDFInfo
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- CN107374688A CN107374688A CN201710582669.XA CN201710582669A CN107374688A CN 107374688 A CN107374688 A CN 107374688A CN 201710582669 A CN201710582669 A CN 201710582669A CN 107374688 A CN107374688 A CN 107374688A
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- changeover portion
- closure end
- aneurysm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
- A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/12031—Type of occlusion complete occlusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/12036—Type of occlusion partial occlusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00902—Material properties transparent or translucent
- A61B2017/00915—Material properties transparent or translucent for radioactive radiation
- A61B2017/0092—Material properties transparent or translucent for radioactive radiation for X-rays
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Abstract
This application discloses plugging device in a kind of tube chamber, it is characterized in that, including closure end (1), changeover portion (2), openend (3), closure end (1) is used to block knurl eck in tube chamber, changeover portion (2) connection closure end (1) is located in vessel lumen with the openend (3), the changeover portion (2).Plugging device in tube chamber provided by the invention, after implantable intravascular, it can stablize and be arranged at vascular bifurcation or blood vessel end latter end, for the closure of intracavitary knurl eck, it can directly block whole last type Aneurysmal neck mouth, last molded breadth carotid aneurysm knurl eck Coil embolization eventually can be also aided in after plugging device is put into.
Description
Technical field
The application is related to intravascular Interventional Treatment technical field, more particularly to plugging device in a kind of tube chamber.
Background technology
Wall of the lumen (particularly arterial wall), which may be formed, is referred to as aneurysmal pathological dilatation region.Aneurysm is a kind of
Common vascular diseases, are due to lesion or the damage of arterial wall, form arterial wall expansion or the result caused by bulging.Human body
At vascular bifurcation and blood vessel wide-angle bending place is that aneurysm easily sends out one of position, and aneurysm knurl wall is very thin, the direct punching press of blood flow
In aneurysm, if without intervening, the aneurysm can expand always, have the danger of rupture at any time, and aneurysm once ruptures,
Great threat will be formed to the life of human body.The position occurred according to aneurysm is different, can be divided into peripheral aneurysm, abdominal aorta
Knurl, aneurysm of thoracic aorta, Visceral artery knurl, cerebral aneurysm etc..For aneurysm shaped like balloon, wall is very thin, is easily broken bleeding, in seconds
It is able to can be in peril of one's life.At present, the method that can be taken for aneurysm has two kinds of open surgery and intravascular Interventional Treatment.And
With the development of interventional technique and updating for apparatus, the advantages that PCI is by minimally invasive, few intercurrent disease, fast post-operative recovery
And it is increasingly becoming and treats aneurysmal important method at present.Handle different parts aneurysm, the specific method of PCI with
Apparatus is not quite similar, for abdominal aneurvsm, aneurysm of thoracic aorta, at present using it is relatively broad be overlay film frame, and be directed to brain
Aneurysm is clogged using relatively broad for turn.
Aneurysm is divided into side wall type aneurysm and eventually last type aneurysm two according to its position and the difference of haemodynamics
Class.Side wall type aneurysm is located at the side of ductus arteriosus wall, the remote of its knurl neck, portions of proximal typically respectively aneurysmal inflow and
Efferent tract.Last type aneurysm is located at the top of arteries crotch eventually, and the center section of its knurl neck is usually aneurysmal stream
Take part in Taoism, peripheral part is usually aneurysmal efferent tract.Last type aneurysm is also often wide neck aneurysm eventually, and its absolute width >=
4mm, or relatively wide neck (knurl neck and Tumor diameter ratio >=1/2).Wide neck aneurysm is the challenge disease of simple Coil embolization treatment
Example, first, being not easy to obtain completeness compactness Coil embolization and easily recur or rupture.There is document report：Wide neck aneurysm causes
Close thrombosis rate is only 15%, and non-wide neck aneurysm Dense embolization rate is 85%.Second, turn easily drops to out of aneurysm
Parent artery, cause normal feeding artery occlusion and form cerebral arterial thrombosis.In recent years, with sacculus ancillary technique, support
The development and application of ancillary technique, double catheter technique technology and close net support blood flow guiding technique, side wall type aneurysm coil bolt
The infull difficult point of plug has been hacked.And last molded breadth carotid aneurysm is still the problem that intravascular Interventional Treatment fails to capture eventually,
Aneurysm recurrence rate is still very high, and more preferable assistive device needs further to be developed.
For side wall molded breadth carotid aneurysm, support secondary spring circle embolism is more conventional treatment means.Typically first will
Across the aneurysm placement of stent delivery catheter, then embolism microtubular is placed in aneurysm away from the 1/2-1/3 of knurl bottom.Lead embolism is micro-
After pipe release partial spring circle, push support through stent delivery catheter and support is discharged in parent artery across aneurysm neck, so
Aneurysm coil embolism is carried out again afterwards, until completeness compactness aneurysm embolism.In support secondary spring circle embolism side wall
In molded breadth carotid aneurysm, the main function of support has at 2 points, first, becoming aneurysmal wide neck as narrow neck, it is therefore prevented that turn is driven
Arteries and veins knurl is overflowed, to realize that completeness compactness aneurysm embolism provides structure support；Second, change the row of parent artery
Direction and curvature are walked, knurl neck is alleviated and flows into road blood flow momentum, so as to reduce aneurysm recurrence.
For last molded breadth carotid aneurysm eventually, above-mentioned support auxiliary aneurysm embolization technique is only applicable to small number of patients, not
Suitable for most of patient.To such aneurysm, Y shape double bracket auxiliary embolization technique has been attempted, but existing defects：It is first, micro-
Conduit enters opposite side artery through the 1st piece of stent mesh can not realize sometimes；Second, when the 1st piece of larger open loop of stent mesh
During support, the section that the 2nd piece of support passes through the 1st piece of stent mesh is opened not exclusively or even not opened.Therefore, solves last molded breadth eventually
The PCI problem of carotid aneurysm is those skilled in the art's urgent problem to be solved.
The content of the invention
In order to solve the above technical problems, first purpose of the present invention is provides plugging device in a kind of tube chamber, it is of the invention
Plugging device, be mainly used in the closure of knurl eck (such as aneurysm) in tube chamber, can directly block eventually last type Aneurysmal neck mouth,
Also last molded breadth carotid aneurysm knurl eck Coil embolization eventually can be aided in after plugging device is put into.
Technical scheme provided by the invention is as follows：
Plugging device in a kind of tube chamber, including closure end, changeover portion, openend, the closure end are used to block in tube chamber
Knurl eck, the changeover portion connection closure end are located in vessel lumen with the openend, the changeover portion.
Preferably, the closure end is all closing or partially enclosed structure.
Preferably, the closure end is provided with mesh.
Preferably, the changeover portion includes sparse section and condensed section, and described sparse section is arranged on the changeover portion close to institute
The one end at closure end is stated, the condensed section is arranged on the one end of the changeover portion away from the closure end.
Preferably, described sparse section is provided with one or more side openings.
Preferably, the closure end is using metal material, macromolecule membrane, or metal material and high molecular film material knot
Conjunction is made, and the changeover portion, openend are made up of metal material.
Preferably, the metal material is Nitinol, Co-Cr alloys, cobalt nickel-molybdenum alloy, one kind in stainless steel or more
Kind.
Preferably, the high molecular film material is polyethylene terephthalate, polytetrafluoroethylene (PTFE), e-PTFE
One or more in ethene.
Preferably, closure end, changeover portion, the openend of the plugging device be by laser engraving or braiding once into
Type, or connect shaping after being manufactured separately.
Preferably, the plugging device also includes one or more indicatings, the indicating using gold, tantalum, platinumiridio,
One or more metals in tungsten are made, the indicating by way of welding or crimping or wind with the plugging device phase
Even.
The plugging device of the present invention, is mainly used in the closure of knurl eck (such as aneurysm) in tube chamber, can directly block whole end
Type Aneurysmal neck mouth, last molded breadth carotid aneurysm knurl eck Coil embolization eventually can be also aided in after plugging device is put into.This hair
It is bright to block end, changeover portion, openend by setting, it is possible to achieve the fixation of tip stabilization, safety at vascular bifurcation and envelope
Plugging intracavitary knurl eck.The closure end is used for the closure of knurl eck in tube chamber, and changeover portion is placed in vessel lumen, for propping up
Support the closure end and the openend.Openend is set to be easy to blood circulation in tube chamber.
Closure end diameter can be more than or equal to knurl neck finish diameter, also be smaller than knurl neck finish diameter.When setting, closure end is straight
Footpath is more than or equal to aneurysm neck finish diameter, is easy to block being bonded for end and aneurysm eck, and end is blocked meanwhile, it is capable to increase
Stability.And when the diameter for blocking end is less than knurl neck finish diameter, as long as closure end can prevent most of blood flow from entering in knurl,
It can then ensure that intraluminal knurl does not rupture, reach closure knurl eck, ensure the effect of patients ' lives safety.Block end diameter with
The size of approach blood vessel is relevant, and because plugging device needs to reach lesion by blood vessel, the size of plugging device is by lesion
Locate the limitation of approach blood vessel size.When approach blood vessel diameter is big, the closure end using large-size can be selected, or use full envelope
The closure end seal closed blocks up knurl eck；When approach hemadostewnosis or distortion angulation, the closure end using small diameter can only be selected,
Or semi-enclosed closure end, whole plugging device is passed through blood vessel and reach lesion region, realize the closure to knurl eck.
Changeover portion is arranged in approach blood vessel, and openend is arranged on the other end of the changeover portion away from closure end, that is, is arranged on
Away from that aneurysmal one end in approach blood vessel, it is to ensure that the blood circulation of approach blood vessel is smooth, make whole to set openend
Individual plugging device can realize the closure to knurl mouth, and the influence of the normal operation to blood vessel is preferably minimized.
The plugging device of the present invention, the diameter at closure end can be set to be more than or equal to the diameter of the changeover portion, also may be used
To set the diameter at closure end to be less than the diameter of the changeover portion.The size that the diameter of changeover portion is generally mated approach blood vessel is set
Put, to reach stable fixation, while do not influence the effect of blood circulation, the diameter of usual changeover portion could be arranged to be slightly larger than into
The diameter of road blood vessel, so as to provide enough radial supports.And the diameter for blocking end needs the diameter for coordinating knurl eck in tube chamber
(such as aneurysm neck breadth) is set, while the approach blood vessel that is dimensioned to pass through for blocking end reaches knurl eck.When approach blood vessel
Diameter is big, can select the closure end using large-size, or block up knurl eck using totally enclosed closure end seal；When approach blood vessel
When narrow, the closure end using small diameter can only be selected, or selects semi-enclosed closure end, whole plugging device is smoothly led to
Cross blood vessel and reach lesion region, realize the closure to knurl eck.Therefore, according to the knurl neck finish diameter in different lesions region, and
The difference of approach blood vessel size, closure end also can be different from the diameter of changeover portion, therefore closure end diameter and changeover portion it is straight
Footpath is compared, according to the difference of lesion region, can set closure end diameter greater than, equal to or less than changeover portion diameter.
The change of closure end diameter can be arranged to be mutated, and can also be arranged to gradual change.
When the closure end of the present invention is arranged to totally enclosed structure, it can be provided closure dish structure, by aneurysm eck
All or part of covering.When closure end is arranged to semi-enclosed structure, it can be provided the structure of ring is blocked, it can also be provided that
One side of something closure, the half of structure not blocked, as long as partial aneurysm eck can be covered, you can what reduction aneurysm crushed can
Energy property, or prevent turn from dropping out.The closure end is provided with mesh.Closure end mesh can set closeer, or block
Polymeric membrane is set in end, enters for obstructing blood in aneurysm, changes blood flow direction, to aneurysm eck at closure end
Part carries out totally-enclosed；It is also settable diluter to block end mesh, or coordinates the structures such as semi-enclosed closure ring, to prevent embolism from moving
Padding (such as turn) drops out aneurysm eck during arteries and veins knurl.Whether closure end sets macromolecule membrane, or the net at closure end
Hole setting is intensive or sparse, can need to set according to actual operation.Macromolecule membrane can coordinate the mesh of comparatively dense common
Set, also sparse mesh can be coordinated to set jointly, macromolecule membrane can also be separately provided.
In practical application, when closure end is arranged to totally enclosed such as closure disk structure, mesh sets closeer or blocked
When macromolecule membrane is provided with end, closure end can be placed at aneurysm eck, aneurysm directly be blocked, the process
Therapeutic device can be avoided to enter in aneurysm, evaded the risk of apparatus puncturing arteries knurl wall, but to transfer passage (i.e. approach
Blood vessel) size require it is higher, it is necessary to the transfer passage of large-size.For thering is transfer passage, larger-size lesion to adopt
Take totally enclosed closure disk to set, realize once-through operation, block wide neck aneurysm.When closure end is arranged to semi-enclosed closure ring
Set diluter or when being separately provided macromolecule membrane etc. structure, mesh, its insulating effect to blood flow is poor, but can reduce institute
The size of the transfer passage needed, for the less lesion of transfer passage size, semi-enclosed closure ring or diluter net can be taken
The closure end of eye, secondary spring circle aneurysm embolization, it can effectively prevent turn from charging into parent artery, the cause of increase spring filling
Density, padding during aneurysm embolization is prevented to drop out aneurysm eck.
The changeover portion of the present invention can set sparse section and condensed section, and sparse section at vascular bifurcation, is easy to blood vessel blood
Stream circulation, especially the blood flow of collatoral vessel can smoothly circulate；Condensed section is placed on vessel lumen (such as approach blood vessel straight section)
In, support strength and enough support forces are provided for closure end, prevents plugging device from shifting.To ensure enough blood circulations, also
One or more side openings can be set at sparse section, further be easy to blood circulation.Side opening is located at vascular bifurcation, at sparse section
Set side opening to easily facilitate the blood circulation of collatoral vessel, the influence that organ runs well will be minimized.
Metal material used in the plugging device can be Nitinol, Co-Cr alloys, cobalt nickel-molybdenum alloy (such as
SUS316), the metal of the good biocompatibility such as stainless steel, or the combination of various metals.The molding mode of changeover portion can be with
The methods of using self-expanding or balloon expandable.The macromolecule membrane that the closure end uses, material can be poly terephthalic acid
Glycol ester (PET), polytetrafluoroethylene (PTFE) (PTFE), expanded PTFE (e-PTFE) etc. can be used for the material of organism.It is logical
For often, the macromolecule membrane, for the thickness of its overlay film between 0.01-0.1mm, the mode of connection can use suture or heat
Bonding etc..Metal material, macromolecule membrane can be used alone, and also can be combined metal material with high molecular film material makes
With.
Closure end, changeover portion, the openend of the plugging device can also may be used by laser engraving or braiding one-shot forming
With the shaping that links together after being manufactured separately, connected mode can be the various ways such as welding or mechanical engagement connection, as long as energy
Firm connecting components simultaneously can be used for the connected mode of organism.
Plugging device sets one or more indicatings, generally sets multiple indicatings, such as 2-10,4-6 indicating, facilitates hand
Develop during art.Indicating can be made by the one or more in the roentgenopaque metal such as gold, tantalum, platinumiridio, tungsten
It is standby.
Plugging device in tube chamber provided by the invention, after implantable intravascular (such as arteries), it can stablize and be arranged on blood vessel
Crotch or blood vessel end latter end, for the closure of intracavitary knurl eck (such as aneurysm), it can directly block last type Aneurysmal neck eventually
Mouth, last molded breadth carotid aneurysm knurl eck Coil embolization eventually can be also aided in after plugging device is put into.The plugging device of the present invention,
Can solve the problems, such as that traditional support secondary spring circle embolism is not suitable for most of end last molded breadth carotid aneurysm treatments, and can solve
Certainly there is the problem of second piece of stenter to implant is difficult and opening is not complete or even does not open in Y shape double bracket secondary spring circle embolism.
Brief description of the drawings
, below will be to embodiment or existing in order to illustrate more clearly of the embodiment of the present application or technical scheme of the prior art
There is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments described in application, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the first structural representation (totally-enclosed) of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 2 is second of structural representation (semiclosed) of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 3 is the third structural representation (totally-enclosed) of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 4 is the 4th kind of structural representation (totally-enclosed) of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 5 is the first schematic diagram of the closure end termination of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 6 is second of schematic diagram of the closure end termination of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 7 is the third schematic diagram of the closure end termination of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 8 is a kind of use state diagram (totally-enclosed) of middle pipe intracavitary plugging device of the embodiment of the present invention；
Fig. 9 is a kind of use state diagram (semiclosed cooperation spring of middle pipe intracavitary plugging device of the embodiment of the present invention
Circle)；
Reference：1- blocks end；2- changeover portions；Sparse section of 201-；202- condensed sections；203- side openings；3- openends；4-
Indicating；
Embodiment
In order that those skilled in the art more fully understand the technical scheme in the application, it is real below in conjunction with the application
The accompanying drawing in example is applied, the technical scheme in the embodiment of the present application is clearly and completely described, it is clear that described implementation
Example only some embodiments of the present application, rather than whole embodiments.It is common based on the embodiment in the application, this area
The every other embodiment that technical staff is obtained under the premise of creative work is not made, it should all belong to the application protection
Scope.
Please as shown in Figures 1 to 9, the embodiment of the present invention provides plugging device in a kind of tube chamber, including closure end 1, transition
Section 2, openend 3, the closure end 1 are used to block knurl eck in tube chamber, the changeover portion 2 connect the closure end 1 with it is described
Openend 3, the changeover portion 2 are located in vessel lumen.
The plugging device of the present invention, is mainly used in the closure of knurl eck (such as aneurysm) in tube chamber, can directly block whole end
Type Aneurysmal neck mouth, last molded breadth carotid aneurysm knurl eck Coil embolization eventually can be also aided in after plugging device is put into.This hair
It is bright to block end 1, changeover portion 2, openend 3 by setting, it is possible to achieve the fixation of tip stabilization, safety at vascular bifurcation is simultaneously
Block knurl eck in tube chamber.The closure end 1 is used for the closure of knurl eck in tube chamber, and changeover portion 2 is placed in vessel lumen, is used
In the support closure end 1 and the openend 3.Openend 3 is set to be easy to blood circulation in tube chamber.
The closure diameter of end 1 can be more than or equal to knurl neck finish diameter, also be smaller than knurl neck finish diameter.End 1 is blocked when setting
Diameter is more than or equal to aneurysm neck finish diameter, is easy to block being bonded for end 1 and aneurysm eck, meanwhile, it is capable to increase closure
The stability at end 1.And when the diameter for blocking end 1 is less than knurl neck finish diameter, as long as closure end 1 can prevent most of blood flow from entering
Enter in knurl, then can ensure that intraluminal knurl does not rupture, reach closure knurl eck, ensure the effect of patients ' lives safety.Block end 1
Diameter it is relevant with the size of approach blood vessel, due to plugging device need by blood vessel reach lesion, the size of plugging device
Limited by lesion approach blood vessel size.When approach blood vessel diameter is big, the closure end 1 using large-size can be selected,
Or block knurl eck using totally enclosed closure end 1；When approach hemadostewnosis or distortion angulation, can only select using smaller straight
The closure end 1 in footpath, or semi-enclosed closure end 1, make whole plugging device pass through blood vessel and reach lesion region, realize to knurl
The closure of eck.
Changeover portion 2 is arranged in approach blood vessel, and openend 3 is arranged on the other end of the changeover portion 2 away from closure end 1, that is, sets
Put in approach blood vessel away from that aneurysmal one end, set openend 3 be in order to ensure that the blood circulation of approach blood vessel is smooth,
Whole plugging device is realized the closure to knurl mouth, and the influence of the normal operation to blood vessel is preferably minimized.
The plugging device of the present invention, the diameter at closure end 1 can be set to be more than or equal to the diameter of the changeover portion 2,
The diameter at closure end 1 can be set to be less than the diameter of the changeover portion 2.The diameter of changeover portion 2 is generally mated the chi of approach blood vessel
Very little setting, to reach stable fixation, while the effect of blood circulation is not influenceed, the diameter of usual changeover portion 2 could be arranged to omit
More than the diameter of approach blood vessel, so as to provide enough radial supports.And the diameter for blocking end 1 needs to coordinate knurl eck in tube chamber
Diameter (such as aneurysm neck breadth) set, while block end 1 be dimensioned to pass through approach blood vessel reach knurl eck.When entering
Road blood vessel diameter is big, can select the closure end 1 using large-size, or block knurl eck using totally enclosed closure end 1；When
During approach hemadostewnosis, the closure end 1 using small diameter can only be selected, or from semi-enclosed closure end 1, make entirely to block
Device passes through blood vessel and reaches lesion region, realizes the closure to knurl eck.Therefore, according to the knurl eck in different lesions region
Diameter, and the difference of approach blood vessel size, closure end 1 also can be different from the diameter of changeover portion 2, therefore block the diameter at end 1
Compared with the diameter of changeover portion 2, according to the difference of lesion region, can set the diameter at closure end 1 greater than, equal to or be less than
Cross the diameter of section 2.
The change of the closure diameter of end 1 can be arranged to be mutated, and can also be arranged to gradual change.
Preferably, the closure end 1 is all closing or partially enclosed structure.
Preferably, the closure end 1 is provided with mesh.
When the closure end 1 of the present invention is arranged to totally enclosed structure, it can be provided closure dish structure, by aneurysm eck
All or part of covering.When closure end 1 is arranged to semi-enclosed structure, it can be provided block the structure of ring, can also set
The structure not blocked for half of closure, one side of something, as long as partial aneurysm eck can be covered, you can reduce what aneurysm crushed
Possibility, or prevent turn from dropping out.The closure end 1 is provided with mesh.Closure end mesh can set closeer, or seal
Polymeric membrane is set in stifled end 1, is entered for obstructing blood in aneurysm, is changed blood flow direction, aneurysm eck is being blocked
The part at end 1 carries out totally-enclosed；It is also settable diluter to block end mesh, or coordinates the structures such as semi-enclosed closure ring, to prevent
Padding (such as turn) drops out aneurysm eck during aneurysm embolization.Whether closure end 1 sets macromolecule membrane, or closure
The mesh setting at end 1 is intensive or sparse, can need to set according to actual operation.Macromolecule membrane can coordinate the net of comparatively dense
Hole is set jointly, also sparse mesh can be coordinated to set jointly, and macromolecule membrane can also be separately provided.
In practical application, when closure end 1 is arranged to totally enclosed such as closure disk structure, mesh sets closeer or blocked
When being provided with macromolecule membrane in end 1, closure end 1 can be placed at aneurysm eck, aneurysm directly be blocked, the mistake
Journey can avoid therapeutic device from entering in aneurysm, evade the risk of apparatus puncturing arteries knurl wall, but to transfer passage (be into
Road blood vessel) size require it is higher, it is necessary to the transfer passage of large-size.For having transfer passage, larger-size lesion can be with
Take totally enclosed closure disk to set, realize once-through operation, block wide neck aneurysm.When closure end 1 is arranged to semi-enclosed envelope
The structures such as blocking ring, mesh set diluter or when being separately provided macromolecule membrane, and its insulating effect to blood flow is poor, but can subtract
The size of small required transfer passage, for the less lesion of transfer passage size, can take semi-enclosed closure ring or compared with
The closure end of dilute mesh, secondary spring circle aneurysm embolization, it can effectively prevent turn from charging into parent artery, increase spring filling
Consistency, prevent aneurysm embolization when padding drop out aneurysm eck.
Preferably, the changeover portion 2 includes sparse section 201 and condensed section 202, and described sparse section 201 is arranged on the mistake
Section 2 is crossed close to the one end at the closure end 1, the condensed section 202 is arranged on one of the changeover portion 2 away from the closure end 1
End.
Preferably, described sparse section 201 is provided with one or more side openings 203.
The changeover portion 2 of the present invention can set sparse section 201 and condensed section 202, and sparse section 201 is located at vascular bifurcation,
It is easy to vascular flow to circulate, especially the blood flow of collatoral vessel can smoothly circulate；Condensed section 202 is placed on vessel lumen (such as
Approach blood vessel straight section) in, support strength and enough support forces are provided for closure end 1, prevents plugging device from shifting.To ensure foot
Enough blood circulations, one or more side openings 203 can also be set at sparse section 201, further be easy to blood circulation.Side opening 203
At vascular bifurcation, the blood circulation of collatoral vessel is easily facilitated in sparse section 201 setting side opening 203, will be normal to organ
The influence of operating minimizes.
Preferably, the closure end 1 is using metal material, macromolecule membrane, or metal material and high molecular film material
With reference to being made, the changeover portion 2, openend 3 are made up of metal material.
Preferably, the metal material is Nitinol, Co-Cr alloys, cobalt nickel-molybdenum alloy, one kind in stainless steel or more
Kind.
Preferably, the high molecular film material is polyethylene terephthalate, polytetrafluoroethylene (PTFE), e-PTFE
One or more in ethene.
Metal material used in the plugging device can be Nitinol, Co-Cr alloys, cobalt nickel-molybdenum alloy (such as
SUS316), the metal of the good biocompatibility such as stainless steel, or the combination of various metals.The molding mode of changeover portion 2 can be with
The methods of using self-expanding or balloon expandable.The macromolecule membrane that the closure end 1 uses, material can be poly terephthalic acid
Glycol ester (PET), polytetrafluoroethylene (PTFE) (PTFE), expanded PTFE (e-PTFE) etc. can be used for the material of organism.It is logical
For often, the macromolecule membrane, for the thickness of its overlay film between 0.01-0.1mm, the mode of connection can use suture or heat
Bonding etc..Metal material, macromolecule membrane can be used alone, and also can be combined metal material with high molecular film material makes
With.
Preferably, the closure end 1 of the plugging device, changeover portion 2, openend 3 are by laser engraving or woven once
Shaping, or connect shaping after being manufactured separately.
The closure end 1 of the plugging device, changeover portion 2, openend 3 can by laser engraving or braiding one-shot forming,
Link together shaping after can also being manufactured separately, and connected mode can be the various ways such as welding or mechanical engagement connection, only
Connecting components can be consolidated and can be used for the connected mode of organism.
Preferably, the plugging device also includes one or more indicatings 4, and the indicating 4 is closed using gold, tantalum, platinoiridita
Gold, one or more metals in tungsten are made, and the indicating 4 is by way of welding or crimping or wind and the plugging device
It is connected.
Plugging device sets one or more indicatings 4, generally sets multiple indicatings 4, such as 2-10,4-6 indicating 4, side
Just develop in surgical procedure.Indicating 4 can be by one kind or more in the roentgenopaque metal such as gold, tantalum, platinumiridio, tungsten
It is prepared by kind.
Fig. 1 to Fig. 4 is the structural representation of plugging device in tube chamber provided in an embodiment of the present invention, and plugging device includes envelope
Stifled end 1, changeover portion 2, the part of openend 3 three, plugging device can use the webmaster (as shown in Figure 1 and Figure 2) of titanium-nickel wire braiding,
Or the NiTi pipe (as shown in Figure 4) after laser engraving, by special shaper, formed after heat treatment.Block end 1, transition
Section 2 and openend 3 can be one-shot forming (as shown in Figure 1, Figure 2, Figure 4 shows), can also separate after being molded, and pass through welding or machinery
Mode links together (as shown in Figure 3).The plugging device made using shape memory metals such as Nitinols, in human vas
It is interior can self-expanding shaping.Plugging device can also use the metal of the non-shape memories such as Co-Cr alloys, stainless steel to make, this
Class device is molded in human body domestic demand by balloon expandable.
In the embodiment of the present invention, closure end termination can be on the outside of woven wire or inner side, and metal termination is on the outside of silk screen
When, can be with (as shown in Figures 5 to 7) on the inside of recessed closure face.Fig. 8 to Fig. 9 is to be blocked in tube chamber provided in an embodiment of the present invention
The use state diagram of device, for the larger-size lesion of transfer passage, it can select to block end 1 as totally-enclosed, closure
Hold 1 mesh closeer or closure end 1 in be provided with the plugging device of polymeric membrane, the plugging device is placed at vascular bifurcation,
Closure end 1 is covered in aneurysm eck, and the closure diameter of end 1 is slightly larger than knurl neck finish diameter, is easy to the closure of aneurysm eck completely,
Meanwhile it can also increase the stability at closure end 1.It may also set up the closure diameter of end 1 and be equal to or less than knurl neck finish diameter, as long as can
Block most blood flow, you can ensure that knurl does not rupture.The process, therapeutic device can be avoided to enter in aneurysm, can be dropped
In low surgical procedure, the risk of apparatus puncturing arteries knurl wall.For the less lesion of transfer passage size, can select to block end
1 sets diluter plugging device for semiclosed, mesh, and closure end 1 is placed on aneurysm eck, then secondary spring circle embolism, energy
It is enough effectively to prevent turn from charging into parent artery, meanwhile, it can also increase the consistency that turn is clogged.
Plugging device in tube chamber provided by the invention, after implantable intravascular (such as arteries), it can stablize and be arranged on blood vessel
Crotch or blood vessel end latter end, for the closure of intracavitary knurl eck (such as aneurysm), it can directly block last type Aneurysmal neck eventually
Mouth, last molded breadth carotid aneurysm knurl eck Coil embolization eventually can be also aided in after plugging device is put into.The plugging device of the present invention,
Can solve the problems, such as that traditional support secondary spring circle embolism is not suitable for most of end last molded breadth carotid aneurysm treatments, and can solve
Certainly there is the problem of second piece of stenter to implant is difficult and opening is not complete or even does not open in Y shape double bracket secondary spring circle embolism.
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one
The most wide scope caused.
Claims (10)
1. plugging device in a kind of tube chamber, it is characterised in that including closure end (1), changeover portion (2), openend (3), the envelope
Stifled end (1) is used to block knurl eck in tube chamber, changeover portion (2) connection closure end (1) and the openend (3), institute
Changeover portion (2) is stated to be located in vessel lumen.
2. device according to claim 1, it is characterised in that closure end (1) is all closings or partially enclosed
Structure.
3. device according to claim 1, it is characterised in that closure end (1) is provided with mesh.
4. device according to claim 1, it is characterised in that the changeover portion (2) includes sparse section (201) and condensed section
(202), sparse section (201) are arranged on the changeover portion (2) close to one end of closure end (1), the condensed section
(202) it is arranged on the one end of the changeover portion (2) away from closure end (1).
5. device according to claim 4, it is characterised in that described sparse section (201) are provided with one or more side openings
(203)。
6. device according to claim 1, it is characterised in that closure end (1) is thin using metal material, macromolecule
Film, or metal material are combined with high molecular film material and are made, and the changeover portion (2), openend (3) are made up of metal material.
7. device according to claim 6, it is characterised in that the metal material is Nitinol, Co-Cr alloys, cobalt
One or more in nickel-molybdenum alloy, stainless steel.
8. device according to claim 6, it is characterised in that the high molecular film material is poly terephthalic acid second two
One or more in alcohol ester, polytetrafluoroethylene (PTFE), expanded PTFE.
9. device according to claim 6, it is characterised in that the closure end (1) of the plugging device, changeover portion (2), open
Mouth end (3) is by laser engraving or weaves one-shot forming, or connects shaping after being manufactured separately.
10. device according to claim 1, it is characterised in that also including one or more indicatings (4), the indicating (4)
It is made of one or more metals in gold, tantalum, platinumiridio, tungsten, the indicating (4) is by welding or crimping or wind
Mode be connected with the plugging device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710582669.XA CN107374688A (en) | 2017-07-17 | 2017-07-17 | Plugging device in a kind of tube chamber |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710582669.XA CN107374688A (en) | 2017-07-17 | 2017-07-17 | Plugging device in a kind of tube chamber |
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| Publication Number | Publication Date |
|---|---|
| CN107374688A true CN107374688A (en) | 2017-11-24 |
Family
ID=60339862
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710582669.XA Pending CN107374688A (en) | 2017-07-17 | 2017-07-17 | Plugging device in a kind of tube chamber |
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| CN113274088A (en) * | 2021-07-02 | 2021-08-20 | 苏州舒通医疗科技有限公司 | Medical implant and plugging system |
| US11583282B2 (en) | 2019-05-21 | 2023-02-21 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device |
| US11583288B2 (en) | 2018-08-08 | 2023-02-21 | DePuy Synthes Products, Inc. | Delivery of embolic braid |
| US11596412B2 (en) | 2018-05-25 | 2023-03-07 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| US11602350B2 (en) | 2019-12-05 | 2023-03-14 | DePuy Synthes Products, Inc. | Intrasaccular inverting braid with highly flexible fill material |
| US11607226B2 (en) | 2019-05-21 | 2023-03-21 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device with corrugations |
| WO2023050520A1 (en) * | 2021-09-28 | 2023-04-06 | 北京泰杰伟业科技有限公司 | Neck aneurysm blocking device |
| US11633191B2 (en) | 2018-10-12 | 2023-04-25 | DePuy Synthes Products, Inc. | Folded aneurysm treatment device and delivery method |
| US11672543B2 (en) | 2017-02-23 | 2023-06-13 | DePuy Synthes Products, Inc. | Aneurysm method and system |
| US11672540B2 (en) | 2018-01-24 | 2023-06-13 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| US11672542B2 (en) | 2019-05-21 | 2023-06-13 | DePuy Synthes Products, Inc. | Aneurysm treatment with pushable ball segment |
| CN117338474A (en) * | 2023-10-10 | 2024-01-05 | 西南交通大学 | Molybdenum-based biodegradable blood flow guiding device and preparation method thereof |
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| US11607226B2 (en) | 2019-05-21 | 2023-03-21 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device with corrugations |
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| US12127743B2 (en) | 2020-09-23 | 2024-10-29 | DePuy Synthes Products, Inc. | Inverting braided aneurysm implant with dome feature |
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| CN117338474A (en) * | 2023-10-10 | 2024-01-05 | 西南交通大学 | Molybdenum-based biodegradable blood flow guiding device and preparation method thereof |
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