US20200085564A1 - Structures and methods for tear shaping for refractive correction - Google Patents

Structures and methods for tear shaping for refractive correction Download PDF

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Publication number
US20200085564A1
US20200085564A1 US16/134,426 US201816134426A US2020085564A1 US 20200085564 A1 US20200085564 A1 US 20200085564A1 US 201816134426 A US201816134426 A US 201816134426A US 2020085564 A1 US2020085564 A1 US 2020085564A1
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Prior art keywords
fibers
selecting
tear
shaping
orientation
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US16/134,426
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English (en)
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Vance M. Thompson
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Tearoptix Inc
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Individual
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Priority to US16/134,426 priority Critical patent/US20200085564A1/en
Priority to US16/373,751 priority patent/US10959834B2/en
Priority to EP19863783.7A priority patent/EP3853659A4/fr
Priority to PCT/US2019/051622 priority patent/WO2020061130A1/fr
Publication of US20200085564A1 publication Critical patent/US20200085564A1/en
Assigned to TEAROPTIX, INC. reassignment TEAROPTIX, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: Thompson, Vance M.
Priority to US17/525,321 priority patent/US20220117723A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/047—Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • G—PHYSICS
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    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
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    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/022—Ophthalmic lenses having special refractive features achieved by special materials or material structures
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    • G02—OPTICS
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    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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    • A61F2250/0056—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
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    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0091—Additional features; Implant or prostheses properties not otherwise provided for transparent or translucent

Definitions

  • Embodiments of the invention relate to refractive vision correction. More particularly they relate to refractive vision correction by shaping the tear film.
  • the tear film covers the anterior structures of the eye and is generally considered to be multilayered in structure. From the corneal surface outward the tear film includes a mucin layer, an aqueous layer and a lipid layer.
  • the mucin layer overlies the surface of the cornea and the conjunctiva and serves to provide an interface between the corneal epithelium and the conjunctival epithelium and the further layers of the tear film. Without the mucin layer the corneal epithelium is generally considered to be hydrophobic because it contains considerable amounts of lipid.
  • Overlying the mucin layer is the aqueous layer consisting largely of water and a small amount of salt and various other trace chemicals.
  • the lipid layer formed of secretions of the meibomian glands and other lipid secreting glands located in and around the eyelids.
  • the tear film protects the tissues of the corneal epithelium from drying and also fills in or bridges minor gaps or irregularities in the corneal epithelium to provide a smooth refractive surface interface between the front of the eye and the ambient atmosphere.
  • the functioning of contact lenses is based on shaping the tear film in that the contact lens both rests upon and is immersed in or covered by the tear film.
  • the anterior most refractive interface between the air and the eye is actually formed by the tear film rather than the cornea itself.
  • the interface between the tear film and the atmosphere represents the most powerful optical focusing interface in the eye.
  • the tear film interface with the atmosphere accounts for approximately two thirds of the focusing power the eye. This focusing power is approximately 43 diopters. Because the focusing power at the tear film interface is so large, small changes in the tear film can have a large effect on refraction and clarity of focusing.
  • Contact lenses can be considered to shape the tear film directly. That is, the contact lens places a new optical surface in front of the corneal epithelium and the tear film flowing over or overlying the anterior surface of contact lens assumes the general shape of the anterior surface of the contact lens in situ.
  • Contact lenses have been in existence for many decades. Early contact lenses were made of glass or rigid plastic such as polymethylmethacrylate (PMMA). Early contact lens designs were quite large and are referred to as scleral or haptic lens. Scleral or haptic contact lens designs cover the cornea completely as well as covering a large portion of the conjunctiva or sclera of the eye. The sclera is the structural white of the eyeball while the conjunctiva is a transparent tissue which overlies the sclera as well as covering the backside of the eye lids. Early contact lens designs were made of rigid, largely oxygen impermeable polymers as discussed above or a very few of glass. Because corneal physiology was poorly understood at the time these lenses were made, they often cause great discomfort and negative effect on corneal health.
  • PMMA polymethylmethacrylate
  • hard contact lenses made of polymethylmethacrylate became much smaller having a diameter significantly smaller than that of the cornea.
  • Hard corneal contact lenses were more comfortable and less physiological damaging than scleral or haptic lenses, but only marginally so.
  • Hard contact lenses still significantly deprived the cornea of a necessary oxygen supply from atmospheric oxygen to maintain good corneal health and were difficult to adapt to.
  • soft corneal contact lenses became available.
  • Soft contact lenses generally are larger than hard corneal contact lenses having a diameter approximating that of the cornea, somewhat larger than the cornea or somewhat smaller than the cornea.
  • Soft contact lenses are generally made of hydrophilic polymers, such as polyhydroxy ethylmethacrylate (poly HEMA), that absorb substantial amounts of water, saline solution or the tear film. Soft contact lenses also provided improved comfort due to their permeability to oxygen and due to their more flexible nature. Later still, so called gas-permeable contact lenses became available. Gas permeable rigid contact lenses are similar in size and structure to hard corneal contact lenses but are made of rigid oxygen permeable polymers that allow oxygen and other gases to pass through the material of the contact lens to provide improved corneal health. Generally, rigid contact lenses provide sharper vision than soft contact lenses though this is not universally true.
  • poly HEMA polyhydroxy ethylmethacrylate
  • Hard contact lenses as well as scleral or haptic contact lenses were sometimes fenestrated. That is, tiny holes were drilled or otherwise formed through the rigid contact lens material in an effort to improve tear exchange under the contact lens or to provide a greater availability of oxygen and other gases through the oxygen impermeable contact lens. Fenestration was generally not a very successful technique. Fenestrations, however, were uniformly tiny holes generally much smaller than one millimeter in diameter. Occasionally multiple fenestrations were present. Fenestrations were generally provided in an effort to benefit the health of the cornea.
  • All contact lenses known to the applicant are formed of substantially solid optical material.
  • Embodiments of the invention are expected to solve many of the above problems.
  • Embodiments of the invention include a variety of structures that shape the tear film indirectly. As discussed above conventional contact lenses shape the fear tear film directly by providing a surface over which the tear film spreads evenly thus altering the shape of the tear film-atmosphere interface.
  • Indirect shaping of the tear film refers to the effect of physical structures on the fear film that is adjacent to the physical structure or structures. Accordingly, indirect shaping of the tear film takes place largely in portions of the tear film that do not overlie the tear shaping structures themselves. Instead, the indirectly shaped portions of the tear film are generally located in spaces between the tear shaping structures. Thus, indirect tear shaping is expected to provide benefits to corneal health by minimizing the amount of material separating the atmosphere in the tear film from the corneal epithelium.
  • Capillary action based tear shaping structures according to example embodiments the invention are unlike conventional contact lenses in that they do not necessarily have an optical focusing effect when they are independent of the tear film or another liquid.
  • Capillary action based tear shaping structures may, according to one example embodiment of the invention, take the form of particulate structures instilled in the tears. Such particulate structures may vary in shape, size and density in order to achieve a desired tear shaping effect. Capillary action based tear shaping structures may also include an interior space or cavity in which tear film may reside to cause or enhance the indirect tear shaping effect.
  • capillary action based tear shaping structures is expected to assist in retaining tears overlying the cornea and also is expected to assist tear exchange and gas exchange at the corneal epithelium. It is also expected that the application of capillary action based tear shaping structures may contribute to the maintenance or improvement of tear film health.
  • a liquid will form a concave meniscus when molecules of the liquid have greater attraction to a solid surface or structure than the liquid's molecules have to each other. Another way of stating this is that a concave meniscus will form when adhesion of the liquid to the solid is greater than cohesion of the liquid to itself. In the case of a liquid that is largely water, such as tears of the eye, this occurs because the polarity of the molecules that make up the solid may be greater than the polarity of the water molecules themselves. Liquids containing nonpolar molecules are more likely to form a convex meniscus.
  • Polarity of the water molecule and hydrogen bonding between water molecules contributes to the cohesion of liquid water and to the surface tension of liquid water.
  • Surface tension of liquid water exists because the water molecules at the surface of the water are more strongly attracted to each other than they are to the surrounding air.
  • tear film shaping structures are utilized to create localized concave menisci and thus a negative optical power to correct for myopia.
  • tear film shaping structures are utilized to create localized convex menisci and thus a positive refractive power to correct for hyperopia or presbyopia.
  • Embodiments of the invention include tear film shaping structures having a meshwork structure that utilize capillary attraction and adhesion between the tear film and the tear film shaping structure to shape the tear film supported by the meshwork thus altering the refractive effect of the tear film.
  • the meshwork structure provides a sufficient platform for the tear film to be shaped like a contact lens shapes the tear film through the capillary attraction and adhesion. It is expected that the closer fibers or structural elements of the structure are the more tear film there will be present thus creating a greater plus power to correct hyperopia. It is also expected that with a greater distance between fibers of the meshwork structure a lesser thickness of tear film will be present centrally and a more negative power to correct myopia will be available.
  • the distance separating fiber structures or structural members within the meshwork lens may be greater at the center and less in the periphery which is expected to provide a myopic correcting lens.
  • the meshwork structure may be more closely spaced a centrally and more distantly spaced peripherally to create a plus powered or hyperopic correcting lens.
  • the meshwork structure is made up of a grid of fibers oriented substantially perpendicular to one another.
  • substantially perpendicular means within 15° of perpendicular.
  • the meshwork structure is made up of radially oriented and circumferentially oriented fibers.
  • the radially oriented fibers may vary from perfectly radially oriented by 15° or more to accomplish the desired tear shaping for refractive outcome.
  • the center point from which the radially oriented fibers emanate may be located at a geometrical center of the meshwork or off-center.
  • the circumferentially oriented or elliptical fibers may describe a true circle or may describe oval or racetrack shapes or other more irregular shapes to create a desired refractive outcome.
  • oval or racetrack shapes may assist in providing correction for astigmatism by shaping the tear film unequally along different meridians.
  • concentric ring structures are thinner and/or separated by a greater distance centrally and are thicker and/or closer together peripherally. It is expected that this will create a minus lens effect for correction of myopia. According to another embodiment of the invention, concentric ring structures are thicker and/or closer together centrally and thinner and/or farther apart preferably which is expected to create a plus lens effect to assist in correcting for hyperopia.
  • the fibers may further support other structures.
  • the fibers may support or include spheres, cubes, tetrahedra or octahedra or other polyhedral shaped structures as well as a ring shaped structures to assist in shaping the tear film.
  • Shapes may also include the five Platonic solids as well as other three-dimensional structures. The shaped structures may be located at intersections of the fibers or at other locations along the fibers.
  • the fibers or rods that form the mesh may vary in thickness, spacing or cross-sectional shape to assist in shaping the tear film.
  • the mesh may also be formed by perforating a solid structure with a multitude of openings.
  • the openings may be circular, square, rectangular, polygonal or any other shape.
  • Such perforations may be accomplished by mechanical machining techniques, laser machining techniques or chemically based techniques. Chemically based techniques may include etching, plating or electroplating for example. Structures including such perforations may also be manufactured by additive manufacturing techniques such as three-dimensional printing.
  • the mesh portion of the structure may be surrounded by a solid supporting perimeter portion.
  • the spacing between structural members of the mesh portion will provide a different refractive correction depending upon spacing of the structural members. It is expected that greater spacing between the structural members will lead to a more negative refractive correction while closer spacing between the structural members will lead to a more positive refractive correction on the basis of capillary attraction or adhesion between the tear film and the structural members of the mesh portion.
  • the structural members of the mesh may include surface features such as nodules or bumps at a microscopic or nano structural size level in order to further assist in shaping the tear film as desired.
  • wettability of the structural members of the mesh may be adjusted by selection of materials and surface texture or surface features to facilitate achieving a desired refractive correction.
  • Materials may be selected for example, based on the polarity of their constituent molecules and/or the relative electronegativity of the atoms in the material.
  • the mesh may be formed of a durable material or may be formed of a bioabsorbable or bio degradable material.
  • dissolvable structures of the mesh can be formed of collagen.
  • the structural members may be separate individual structural members that are positioned relative to one another by attractive and repulsive forces.
  • the structural members may be applied as a liquid suspension which is instilled into the tears such that individual structural members may position themselves relative to one another by attractive and repulsive forces.
  • the structural members may be supported in a sol or gel suspension.
  • the structural members may also be partially cross-linked or interlinked while in the suspension and further organized once instilled in the tear film.
  • the structural members may be organized by electrostatic forces, magnetic forces, intermolecular forces, and/or various repulsive and/or attractive forces.
  • structural members may vary in size and configuration.
  • a suspension may include structural members of a single size and configuration or of several sizes and configurations.
  • the mesh or structural refractive members may be organized to provide correction for myopia, presbyopia, hyperopia, astigmatism, and prismatic correction.
  • the structural members may include microscopic structural members, nanostructural members or nano-robots.
  • meshwork structural members may be configured to provide correction for myopia, hyperopia, astigmatism, presbyopia and other refractive errors.
  • meshwork structural members may be configured to improve image quality by reducing higher-order aberrations or spherical aberration of the eye or by providing compensation for corneal irregularities that exist due to disease or injury.
  • meshwork structural members may be formed of materials utilized in the manufacture of soft or rigid contact lenses. They may also be formed of materials that are intended for long-term use or materials that are biodegradable or bioabsorbable or configured for disposable use.
  • meshwork structures may include various sizes of particles that are grouped or utilized for support to influence tear film shape to correct village vision including nanostructures and nanotechnology.
  • capillary attraction, surface tension and other forces are used to shape the tear film by application of the meshwork structures.
  • the meshwork or tear shaping structure provides a sufficient structural platform for the tear film to be shaped in a similar way to that like a contact lens shapes the tear film but based on capillary attraction, adhesion, surface tension and other forces.
  • a large number of tiny spheres or objects of various shapes and sizes can be instilled in the tear film.
  • the effect of these multiple objects is expected to be to change the shape of the tear film between the multiple objects thereby creating a desired refractive effect at the interface between the tear film and the atmosphere.
  • the tear film may be caused to take on a concave shape between adjacent objects in the tear film thus creating a negative lens effect to assist in correction of myopia.
  • a toric focusing effect may be accomplished to assist in correction of astigmatism
  • a plus lens effect may be achieved to assist in correction of hyperopia in that a multifocal effect may be obtained to assist in the correction of presbyopia.
  • various shapes of objects may be used to define the distance between the objects to achieve a desired tear film shaping to provide refractive correction.
  • the invention a large number of tiny rings or hollow cylindrical objects may be instilled into the tear film. It is expected that the effect of these rings or hollow cylindrical objects will be to alter the curvature of the overlying tear film such that incoming light rays made the divergent by a plus or minus lens effect created between the particles and/or that incoming light rays may be convert by a plus lens effect created over are within the open part of the rings or hollow cylindrical objects in the tear film.
  • refractive effects may be achieved.
  • refractive effects to assist in correction of myopia, hyperopia, astigmatism, presbyopia and prismatic effect may be achieved.
  • FIG. 1 is a schematic depiction of a meshwork tear shaping structure having an evenly spaced grid pattern according to an example embodiment of the invention
  • FIG. 2 is a schematic depiction of a meshwork tear shaping structure having a grid pattern more closely spaced peripherally than centrally according to an example embodiment of the invention
  • FIG. 3 is a schematic depiction of a meshwork tear shaping structure having a grid pattern more closely spaced centrally than peripherally according to an example embodiment of the invention
  • FIG. 4 is a schematic depiction of a meshwork tear shaping structure having meshwork structures oriented radially and circularly and more closely spaced peripherally than centrally according to an example embodiment of the invention
  • FIG. 5 is a schematic depiction of a meshwork tear shaping structure having meshwork structures oriented radially and circularly and more closely spaced centrally than peripherally according to an example embodiment of the invention
  • FIG. 6 is a schematic depiction of a meshwork tear shaping structure having meshwork structures oriented radially and elliptically and more closely spaced centrally than peripherally according to an example embodiment of the invention
  • FIG. 7 is a schematic depiction of a meshwork tear shaping structure having meshwork structures oriented radially and elliptically and more closely spaced peripherally than centrally according to an example embodiment of the invention
  • FIG. 8 is a schematic depiction of a meshwork tear shaping structure having additional structural components at junctions of fibers
  • FIG. 9 is a schematic depiction of a tear shaping formation including a large number individual structural components instilled in a tear film according to an example embodiment of the invention.
  • FIG. 10 is a schematic depiction of a tear shaping formation including a large number individual structural components that are cylindrical or of another shape instilled in a tear film according to an example embodiment of the invention
  • FIG. 11 is a schematic depiction of a tear shaping formation including a large number of multi-lobate individual structural components instilled in the tear film according to a further example embodiment of the invention.
  • FIG. 12 is a schematic depiction of a tear shaping formation including a large number of individual structural components that are ring-shaped or hollow cylindrical shaped instilled in the tear film according to a further example embodiment of the invention
  • tear shaping structure 10 may include a lenticular structure 12 having perimeter ring 14 and grid 16 of fibers 18 .
  • Perimeter ring 14 supports grid 16 of fibers 18 .
  • grid 16 of fibers 18 includes horizontal fibers 20 and vertical fibers 22 .
  • the adjectives horizontal and vertical are used here for convenience of description and merely to distinguish the substantially perpendicular relative orientation of horizontal fibers 20 from vertical fibers 22 .
  • Horizontal fibers 20 and vertical fibers 22 can be in any orientation however they are oriented approximately perpendicular to each other. In the context of the invention approximately perpendicular means within plus or minus 15° of 90°.
  • horizontal fibers 20 are substantially evenly spaced from other horizontal fibers 20 that are generally parallel thereto and vertical fibers 22 are substantially evenly spaced from other vertical fibers 22 that are generally parallel thereto.
  • Lenticular structure 12 may be formed as a shell having a shape approximating a portion of the sphere.
  • Fibers 18 and other structures utilized in tear shaping herein include but are not limited to fibers 18 , particles, microscopic particles, nanoparticles, nanostructures or nano robots may be collectively referred to as capillary action structures. This is because the above identified capillary action structures enable the tear film to interact with the capillary action structures to cause shaping of the tear film to support a desired refractive result.
  • a depicted example embodiment also includes perimeter ring 14 supporting grid 16 of fibers 18 including horizontal fibers 20 and vertical fibers 22 .
  • horizontal fibers 20 and vertical fibers 22 are more distantly spaced centrally and more closely spaced peripherally.
  • tear shaping that will focus light to have an overall refractive effect similar to minus power lens to assist in the correction of myopia.
  • horizontal fibers 20 and vertical fibers 22 may be more closely spaced centrally and vertical fibers 22 may be more closely spaced peripherally in which case, it is expected that a mixed astigmatic correction will be achieved.
  • horizontal fibers 20 and vertical fibers 22 may both be space more closely either peripherally or centrally but in varying degrees of spacing.
  • FIG. 3 another example embodiment of tear shaping structure 10 is depicted.
  • horizontal fibers 20 and vertical fibers 22 are more closely spaced a centrally than peripherally. It is expected that such a configuration will provide a tear shape having a focusing effect similar to a plus lens to assist in correcting refractive error for hyperopia.
  • horizontal fibers 20 and vertical fibers 22 maybe differently spaced from each other as to which is spaced closer centrally and which is spaced closer peripherally.
  • FIG. 4 another schematic example embodiment of tear shaping structure 10 is depicted.
  • the depicted embodiment elliptical fibers 24 and radial fibers 26 are utilized.
  • Elliptical fibers 24 extend generally around a center 28 of tear shaping structure 10 .
  • elliptical fibers 24 may follow a circular path or may follow another closed path that includes but is not limited to circular, oval, elliptical or racetrack shaped in nature.
  • radial fibers 26 extend generally through center 28 and to periphery 30 of tear shaping structure 10 .
  • elliptical fibers 24 are spaced more closely peripherally and more distantly centrally. It is expected that such an arrangement will lead to a negative refractive correction for correcting myopia.
  • elliptical fibers 24 are to be understood to include fibers that define a circular path or shape or the other paths or shapes discussed above. It is noted that, from a geometrical standpoint, it is to be understood that a circle is a special case of an ellipse in which the major and minor axis of the ellipse are equal. Thus, elliptical fibers 24 include circular fibers as well.
  • FIG. 5 another example embodiment of tear shaping structure 10 is schematically depicted.
  • This embodiment also includes elliptical fibers 24 and radial fibers 26 .
  • elliptical fibers 24 are spaced more closely together centrally and more distantly from each other peripherally. Such a configuration is expected to provide a positive refractive correction for correcting myopia.
  • FIG. 6 another example embodiment of tear shaping structure 10 is schematically depicted.
  • elliptical fibers 24 are elliptically arranged and may be referred to as elliptical fibers 32 .
  • the range of elliptical fibers 32 is more closely spaced centrally and more distantly spaced peripherally. This configuration is expected to provide a refractive correction appropriate for correcting astigmatism.
  • FIG. 7 another example embodiment of tear shaping structure 10 is schematically depicted.
  • elliptical fibers 32 are present and spaced more closely peripherally than they are centrally.
  • radial fibers 26 are present and spaced more closely angularly in some orientations than other orientations. The depicted arrangement is expected to assist in providing refractive correction for astigmatism.
  • FIG. 8 a schematic depiction of a grid structure of a tear shaping structure 10 is depicted having additional structural components at junctions 34 of fibers 18 .
  • fibers 18 includes horizontal fibers 20 and vertical fibers 22 .
  • Junctions 34 include additional spherical structures 36 .
  • Embodiments of the invention are not, however, limited to spherical structures 36 . Similar structures may be present in other shapes such as cubes, tetrahedra, octahedra or other polyhedral shapes including for example, the five Platonic solids. Other three-dimensional structures may be utilized as well.
  • spherical structures 36 may also be located at junctions of elliptical fibers 24 and radial fibers 26 .
  • fibers 18 may be formed to be thicker or thinner than other of fibers 18 . Variations in fiber 18 thickness are expected to provide a different refractive correction or prismatic correction. According to another example embodiment of the invention fibers 18 may vary in cross sectional shape to assist in shaping the tear film. Cross-sectional shapes may include but are not limited to circular, polygonal, triangular, dentate or irregular shapes.
  • tear shaping structure 10 may be formed by perforating a solid structure with a multitude of openings.
  • the openings may be circular, square, rectangular, polygonal or of any other shape.
  • perimeter ring 14 may surround a periphery of tear shaping structure 10 .
  • Perimeter ring 14 may be formed of similar material to the rest of tear shaping structure 10 or may be formed of an alternative material, for example, a material of greater rigidity than the rest of tear shaping structure 10 .
  • additional surface features 38 may include textured features 40 .
  • Surface features 38 including textured features 40 may present nodules or indentations of a microscopic or nano structural size level in order to further assist in shaping the tear film as desired.
  • Tear shaping structure 10 may be formed of a durable material or may be formed of a bioabsorbable or biodegradable material. According to one example embodiment tear shaping structure 10 may be formed of collagen.
  • tear shaping structure 10 may include independent tear shaping objects 42 .
  • Independent tear shaping objects 42 may include micro-balloons, microspheres, micro rings, irregular shaped objects or a combination of the foregoing.
  • Independent tear shaping objects 42 may vary in size.
  • tear shaping objects 42 may include microspheres 44 . As depicted in FIG. 9 , microspheres 44 are dispersed relatively evenly in tear film 46 . The presence of tear shaping objects 42 such as microspheres 44 is expected to cause tear film 46 to present convex areas 48 and concave areas 50 . Depending upon the size, shape and spacing of tear shaping objects 42 is expected that either convex areas 48 or concave areas 50 will dominate and contribute to a positive refractive correction or a negative refractive correction. A positive refractive correction is expected to occur if convex areas 48 dominate. A negative refractive correction is expected to occur if concave areas 50 dominate. Tear film 46 and tear shaping objects 42 are depicted overlying cornea 52 .
  • FIG. 10 an example embodiment of the invention is depicted in which concave areas 50 indirectly created dominate thus a negative refractive effect is expected.
  • tear shaping objects 42 may include irregular shapes such as multi-lobate tear shaping object 54 .
  • Multi-lobate tear shaping object 54 are expected to enable control distance between tear shaping objects 42 thus assisting in control of the tear film shaping.
  • Micro rings 56 include ring-shaped or cylinder shaped objects having an open center. Depending upon the size of micro rings 56 it is expected that positive refractive effects or negative refractive effects may be achieved. Tear shaping micro rings 56 may include circular, elliptical, oval and/or racetrack shaped rings. Micro rings 56 may have a ring a portion that is the same size around its entire circumference or a ring-shaped portion that varies in size around the circumference.
  • FIG. 12 also includes a depiction of light rays 58 impinging upon tear film 46 in convex areas 48 and concave areas 50 .
  • Parallel light rays 60 impinging upon concave areas 50 are diverged which is expected to lead to a minus lens effect by creating diverging light rays 62 .
  • Parallel right light rays 60 impinging upon convex areas 48 are converged which is expected to lead to a plus lens effect by creating converging light rays 64 .
  • independent tear shaping objects 42 may be positioned relative to one another by attractive and repulsive forces.
  • independent tear shaping objects 42 may be applied dispersed in a liquid suspension which is instilled into the tears such that individual structural members may position themselves relative to one another by attractive and repulsive forces once introduced into the tear film.
  • Independent tear shaping objects 42 may be supported in a sol or gel suspension.
  • Independent tear shaping objects 42 may also be partially cross-linked or interlinked while in the suspension and further organized once instilled into the tear film.
  • Independent tear shaping objects 42 may be organized by capillary action in combination with electrostatic forces, magnetic forces, intermolecular forces, and/or various repulsive and/or attractive forces. According to example embodiments of the invention Independent tear shaping objects 42 may vary in size and configuration. A suspension may include independent tear shaping objects 42 of a single size and configuration or of several sizes and configurations. According to example embodiments of the invention, independent tear shaping objects 42 may be organized to provide correction for myopia, presbyopia, hyperopia, astigmatism, and prismatic correction.
  • independent tear shaping objects 42 may include microscopic structural members, nanostructural members or even nano-robots.
  • independent tear shaping objects 42 may be configured to provide correction for myopia, hyperopia, astigmatism, presbyopia and other refractive errors.
  • capillary action structures, meshwork structural members or independent tear shaping objects 42 may be configured to improve image quality by reducing higher-order aberrations or spherical aberration of the eye or by providing compensation for corneal irregularities that exist due to disease or injury.
  • tear shaping structure 10 is applied to an eye.
  • lenticular structure 12 lenticular structure 12 is applied to the eye in a way that is similar to application of a contact lens.
  • Grid 16 of fibers 18 interacts with the tear film in such a way that the tear film occupies the space between horizontal fibers 20 , vertical fibers 22 , elliptical fibers 24 and/or radial fibers 26 because of capillary action. Capillary action causes the tear film to be shaped such that it has a changed refractive effect from the unshaped tear film.
  • fibers 18 contribute to shaping of the tear film such that the tear film does not create a smooth layer over the corneal surface and instead alters the refractive interface between the tear film and the atmosphere to create a desired refractive effect to compensate for ametropia.
  • refractive effects are expected to include compensation for astigmatism and/or compensation for prismatic effects.
  • Varying spacing of elliptical fibers 24 and/or radial fibers 26 also are expected to provide refractive compensation for astigmatism.
  • independent tear shaping objects 42 these structures may be introduced into the eye in a liquid suspension or a sol/gel suspension.
  • Independent tear shaping objects 42 are expected to organize themselves because of attractive and repulsive forces to alter the tear film to provide refractive benefits.

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EP19863783.7A EP3853659A4 (fr) 2018-09-18 2019-09-18 Structures et procédés de formation de larmes pour la correction de la réfraction
PCT/US2019/051622 WO2020061130A1 (fr) 2018-09-18 2019-09-18 Structures et procédés de formation de larmes pour la correction de la réfraction
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US10959834B2 (en) 2021-03-30
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WO2020061130A1 (fr) 2020-03-26
EP3853659A4 (fr) 2022-06-22

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