US20170166586A1 - Process for making tetracyclic heterocycle compounds - Google Patents

Process for making tetracyclic heterocycle compounds Download PDF

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Publication number
US20170166586A1
US20170166586A1 US15/325,392 US201515325392A US2017166586A1 US 20170166586 A1 US20170166586 A1 US 20170166586A1 US 201515325392 A US201515325392 A US 201515325392A US 2017166586 A1 US2017166586 A1 US 2017166586A1
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US
United States
Prior art keywords
compound
step
alkyl
ml
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US15/325,392
Inventor
Hongming Li
Jingjun Yin
Kevin M. Belyk
Kevin R. Campos
Qinghao Chen
Alan M. Hyde
Tetsuji Itoh
Artis Klapars
Matthew Thomas Tudge
Edward Cleator
Aaron M. Dumas
Louis-Charles Campeau
Yonggang Chen
Ji Qi
Wensong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD R&D China Co Ltd
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme Corp
Original Assignee
Hongming Li
Jingjun Yin
Kevin M. Belyk
Kevin R. Campos
Qinghao Chen
Alan M. Hyde
Tetsuji Itoh
Artis Klapars
Mathew Thomas TUDGE
Edward Cleator
Aaron M. Dumas
Louis-Charles Campeau
Yonggang Chen
Ji Qi
Wensong Xiao
Merck Sharp & Dohme Corp.
Merck Sharp & Dohme Limited
Msd R&D (China) Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201462023395P priority Critical
Priority to US201562171012P priority
Application filed by Hongming Li, Jingjun Yin, Kevin M. Belyk, Kevin R. Campos, Qinghao Chen, Alan M. Hyde, Tetsuji Itoh, Artis Klapars, Mathew Thomas TUDGE, Edward Cleator, Aaron M. Dumas, Louis-Charles Campeau, Yonggang Chen, Ji Qi, Wensong Xiao, Merck Sharp & Dohme Corp., Merck Sharp & Dohme Limited, Msd R&D (China) Co., Ltd filed Critical Hongming Li
Priority to US15/325,392 priority patent/US20170166586A1/en
Priority to PCT/CN2015/083786 priority patent/WO2016004899A1/en
Publication of US20170166586A1 publication Critical patent/US20170166586A1/en
Assigned to MSD R&D (CHINA) CO., LTD reassignment MSD R&D (CHINA) CO., LTD ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: QI, Ji
Assigned to MERCK SHARP & DOHME LIMITED reassignment MERCK SHARP & DOHME LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CLEATOR, EDWARD, DUMAS, Aaron M.
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CAMPEAU, LOUIS-CHARLES, CHEN, YONGGANG, CHEN, QINGHAO, BELYK, KEVIN M., CAMPOS, KEVIN R., HYDE, Alan M., ITOH, TETSUJI, KLAPARS, ARTIS, LI, HONGMING, YIN, JINGJUN
Assigned to PHARMARON BEIJING CO. LTD. reassignment PHARMARON BEIJING CO. LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: XIAO, WENSONG
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PHARMARON BEIJING CO., LTD.
Application status is Abandoned legal-status Critical

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