US20160375182A1 - Syringe fill method and apparatus - Google Patents
Syringe fill method and apparatus Download PDFInfo
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- US20160375182A1 US20160375182A1 US15/262,999 US201615262999A US2016375182A1 US 20160375182 A1 US20160375182 A1 US 20160375182A1 US 201615262999 A US201615262999 A US 201615262999A US 2016375182 A1 US2016375182 A1 US 2016375182A1
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- manifold
- inlet
- barrel
- tissue
- outlet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/64—Containers with integrated suction means
- A61M1/67—Containers incorporating a piston-type member to create suction, e.g. syringes
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- A61M1/0009—
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- A61M1/007—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/80—Suction pumps
- A61M1/81—Piston pumps, e.g. syringes
- A61M1/815—Piston pumps, e.g. syringes the barrel serving as aspiration container, e.g. in a breast pump
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/89—Suction aspects of liposuction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/08—Lipoids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/09—Body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2250/00—Specially adapted for animals
Definitions
- a syringe fill method and apparatus are disclosed. More particularly, a modular system and method for filling one or more syringes with tissue, including but not limited to fat, in connection with tissue transfer operations are disclosed.
- Microlipoinjection is a process in which fat is taken by a cannula from one spot in the body and reinjected in another place in the body. Microlipoinjection has also been known as liposuction with fat transfer, fat grafting or fat transplantation. In general, microlipoinjection is performed to treat divots and scar indentations from trauma to the face or body, such as may occur as a secondary effect of domestic trauma, surgery or infection. Microlipoinjection can also be used to treat the effects of the loss of the subcutaneous layer of fat due to the normal aging process, either alone or in combination with facelift and fat grafting techniques. Other uses for microlipoinjection include providing filler to reapproximate weakened vocal cords, filling sinuses, or partially closing incompetent valves.
- stem cells are the precursor to healthy fat cells, and also have a limited ability to differentiate into different tissue. When placed in fat they will divide several times into mature fat cells and more adult stem cells. These stem cells are an important part of a tissue harvest.
- a modular collection apparatus features a manifold structure.
- the manifold structure includes one or more manifold elements.
- Each manifold element has a coupler for interconnecting a syringe body to the manifold element, optionally includes a barrel or bore for receiving a syringe plunger aligned with the syringe body, an inlet, and an outlet.
- a barrel inlet and a barrel outlet can also be incorporated, with the barrel inlet offset from the barrel outlet to promote the deposition of tissue into the barrel or body of an attached syringe.
- a first manifold cap that includes a connector for interconnecting the apparatus to a source of tissue can be joined to the inlet of a first manifold element.
- a second manifold cap that includes a connector for interconnecting the apparatus to a vacuum source can be joined to the outlet of the last manifold element.
- a method for depositing collected tissue into one or more syringes are provided. More particularly, one or more manifold elements and a syringe barrel associated with each of the manifold elements are joined to a source of tissue by a first manifold cap, and to a vacuum source by a second manifold cap. Tissue is drawn through the inlet by a vacuum from the vacuum source.
- the tissue may be obtained from a patient using a cannula attached to the first manifold cap by a length of flexible tubing. At least some tissue drawn in through the first manifold cap is deposited in a first syringe barrel attached to a first manifold element. The deposition of tissue in the first syringe barrel can be encouraged through the provision of a barrier or wall that prevents the collected tissue from being drawn across the top of the syringe barrel unimpeded. Once the first syringe barrel is full of tissue, any additional tissue drawn in to the apparatus is drawn to a second manifold element and associated syringe barrel (if provided). Accordingly, multiple syringe barrels can be filled sequentially.
- the vacuum source can be turned off or disconnected, and the syringe barrel associated with a first manifold element can then be disconnected from the first manifold element.
- the tissue in the syringe can then be injected into the patient through a needle or cannula attached to the syringe barrel, at the urging of a plunger inserted into the barrel, or deposited into another receptacle for processing.
- FIG. 1 illustrates a front perspective view of the modular tissue collection apparatus in accordance with an embodiment of the disclosed invention
- FIG. 2A is a top plan view of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 2B is a left side elevation view of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 2C is a rear elevation view of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 2D is a left side elevation view of the syringe element of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 2E is a left side elevation view of another embodiment of the syringe element of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 2F is a cross-sectional view of section A-A of FIG. 2B ;
- FIG. 2G is a cross-sectional view of section B-B of FIG. 2B ;
- FIG. 3A is a front perspective view of a manifold element of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 3B is a rear perspective view of a manifold element of the modular tissue collection apparatus of the embodiment of FIG. 1 ;
- FIG. 4A is a top plan view of the modular tissue collection apparatus in accordance with another embodiment of the present invention.
- FIG. 4B is a left side partial cross-sectional elevation view of the modular tissue collection apparatus of the embodiment of FIG. 4A ;
- FIG. 5A is a front perspective view of the modular tissue collection apparatus in accordance with another embodiment of the present invention.
- FIG. 5B is a left side cross-sectional elevation view of the modular tissue collection apparatus of the embodiment of FIG. 5A ;
- FIG. 6A is a perspective view of a manifold element in accordance with an embodiment of the present invention.
- FIG. 6B is a perspective view of a manifold element in accordance with another embodiment of the present invention.
- FIG. 7 is a perspective view of a manifold cap in accordance with an embodiment of the present invention.
- FIG. 8 illustrates a top plan view of an example construction of a particular embodiment of the modular tissue collection apparatus—the drawing is to scale with dimensions in inches;
- FIG. 9 illustrates a left side elevation view of an example construction of a particular embodiment of the modular tissue collection apparatus of FIG. 8 —the drawing is to scale with dimensions in inches;
- FIG. 10 illustrates a rear elevation view of an example construction of a particular embodiment of the modular tissue collection apparatus of FIG. 8 —the drawing is to scale with dimensions in inches;
- FIG. 11 illustrates a left side elevation view of the syringe element of an example construction of a particular embodiment of the modular tissue collection apparatus of FIG. 8 —the drawing is to scale.
- a modular tissue collection system or apparatus 100 in accordance with embodiments of the disclosed invention is illustrated in elevation in FIG. 1 .
- the apparatus 100 features a manifold element 108 comprising a coupler 120 , manifold barrel or bore 128 , manifold input structure 104 and an opposing manifold output structure 105 .
- the manifold input structure 104 connects with a first or inlet manifold cap 112 comprising an inlet orifice 136 .
- the manifold output structure 105 connects with a second or outlet manifold cap 116 comprising an outlet orifice 140 .
- each of these two afore-mentioned connections are interference fits.
- Each of the manifold input structure 104 and manifold output structure 105 engage a coupler 120 to which a syringe body or barrel 124 is connected, at least while the apparatus in an assembled state.
- Each manifold element 108 also includes a plate 122 which may be used, for example, to mount or secure the modular tissue collection apparatus 100 to, for example, a “universal stand” as typical in health care environments.
- An aperture may optionally be included on the plate 122 itself or proximal to the plate 122 , such as on a connecting element between the plate 122 and the manifold element 108 , to engage a chain or similar to secure the modular tissue collection apparatus 100 .
- the apparatus is sealed from an inlet orifice 136 at the first manifold cap 112 to an outlet orifice 140 at the second manifold cap 116 .
- the inlet orifice 136 can be connected to a tissue source, for example through a length of flexible tubing and a cannula, and the outlet orifice 140 can be connected to a vacuum source.
- the tissue flow is reversed, i.e.
- the outlet orifice 140 can be connected to a tissue source, for example through a length of flexible tubing and a cannula, and the inlet orifice 136 can be connected to a vacuum source.
- each syringe barrel 124 can be sealed at a tip end by a syringe cap 144 , such that the apparatus 100 is completely sealed between the inlet orifice 136 and the outlet orifice 140 , at least when the apparatus 100 is configured for tissue collection.
- FIGS. 2A-C provide a top plan view, a left side elevation view, and a rear elevation view of the modular tissue collection apparatus of the embodiment of FIG. 1 .
- a modular tissue collection apparatus 100 comprises a manifold input structure 104 engaged with a first manifold cap 112 comprising an inlet orifice 136 .
- the inlet orifice 136 is connected with tubing 150 .
- the tubing 150 may be any commercially available tubing as used, for example, in medical procedures.
- the tubing 150 fits over an inlet orifice 136 as an interference fit. In other embodiments, the tubing 150 is clamped to the inlet orifice 136 or otherwise engaged so as to maintain a fluid seal.
- the manifold output structure 105 engages an output manifold cap 116 comprising an outlet orifice 140 .
- the outlet orifice 140 connects to vacuum source (not shown) so as to create suction, or a negative pressure between the inlet orifice 136 and the outlet orifice 140 , thereby urging tissue into the modular tissue collection apparatus 100 via the inlet orifice 136 .
- the syringe barrel 124 comprising a syringe cap 144 , attaches to the manifold element 108 via a coupler 120 .
- the coupler 120 includes two parallel tracks configured to receive the top of the syringe barrel 124 .
- the coupler 120 is any means to engage a syringe barrel as known to those skilled in the art, to include a complete or partial ring to enable an interference fit.
- FIG. 2D is a left side elevation view of the syringe barrel 124 with a syringe plunger 132 .
- the syringe barrel 124 and/or the syringe plunger 132 are any designs as commercially available.
- a distal end of the syringe plunger 132 comprises an outer radial portion, such as a gasket or o-ring, which provides a more secure fit or seal than that typically commercially available. More specifically, an outer radial portion that maintains a fluid seal when receiving a pressure as great as 29.92 inHg (i.e. 1 atm).
- the outer radial portion maintains a fluid pressure up to 20 inHg.
- the outer radial portion maintains a fluid pressure of approximately 15 inHg
- FIG. 2E is a left side elevation view of another embodiment of the syringe barrel 124 with a syringe plunger 132 .
- the syringe plunger 132 is specially configured to prevent and/or avoid waste. More particularly, rather than featuring a conventional plunger tip, a hollow tip 133 portion is provided. The volume of the hollow tip 133 allows tissue at the top of the syringe barrel 124 to be trapped, rather than displaced, when the plunger 132 is moved down the manifold element barrel 128 , into the syringe barrel 124 .
- FIGS. 2F-G illustrate cross-sectional views of sections A-A and B-B, respectively, of FIG. 2B .
- the modular tissue collection apparatus 100 comprises the manifold element 108 comprising the inlet aperture 216 and the barrel inlet 208 , and the outlet aperture 220 and the barrel outlet 212 .
- the barrel inlet 208 at least partially directs or urges incoming or received material, such as tissue, downward into the syringe barrel 124 .
- the vertical offset of the barrel outlet 212 relative to the barrel inlet 208 at least partially directs or urges incoming or received fluid, such as tissue, as received from the inlet orifice 136 , to drop into the syringe barrel 124 .
- the barrel outlet 212 allows received material, such as tissue, to pass toward the outlet aperture.
- FIGS. 3A-B illustrate front perspective views of the modular tissue collection apparatus of the embodiment of FIG. 1 .
- the manifold element 108 comprises a manifold input structure 104 , a manifold output structure 105 and a coupler 120 .
- the manifold input structure 104 surrounds an inlet aperture 216 , with a distal diameter larger than a distal diameter of the outlet aperture 220 .
- Each of the manifold input structure 104 and the manifold output structure 105 taper in external diameter with distance from the coupler 120 .
- the internal diameters of one or both of the manifold input structure 104 and the manifold output structure 105 similarly taper in diameter with distance from the coupler 120 .
- each of the manifold input structure 104 and the manifold output structure 105 do not taper and are of constant diameter with distance from the coupler 120 .
- FIGS. 4A-B illustrate a top plan view, and a left side partial cross-sectional elevation view, respectively, of the modular tissue collection apparatus of the embodiment of FIG. 1 as configured with a plurality of manifold elements 108 and associated syringe barrels 124 .
- the embodiment of FIGS. 4A-B is constructed of the modular components of FIG. 1 .
- a series of three sets of manifold elements 108 with attached syringe barrels 124 is shown.
- a first manifold cap with an inlet orifice 136 connects with tubing 150 which in turn is engaged with a source of tissue.
- An outlet manifold cap 116 connects with a vacuum source (not shown) via an outlet orifice 140 .
- the first manifold element 108 may have an inlet aperture 216 that is joined to the first manifold cap 112 , and an outlet aperture 220 that is joined to either the inlet aperture 216 of a second manifold element 108 , or to the second manifold cap 116 .
- the manifold structure can be configured with from one to any number of manifold elements 108 .
- Each manifold element 108 includes a coupler 120 to which a syringe body or barrel 124 is connected, at least while the apparatus in an assembled state.
- each syringe barrel 124 With a syringe barrel 124 connected to each manifold element 108 , the apparatus is sealed from an inlet orifice 136 at the first manifold cap 112 to an outlet orifice 140 at the second manifold cap 116 .
- the inlet orifice 136 can be connected to a tissue source, for example through a length of flexible tubing and a cannula, and the outlet orifice 140 can be connected to a vacuum source.
- each syringe barrel 124 can be sealed at a tip end by a syringe cap 144 , such that the apparatus 100 is completely sealed between the inlet orifice 136 and the outlet orifice 140 , at least when the apparatus 100 is configured for tissue collection.
- tissue enters inlet orifice 136 it enters the first of three manifold input structures 112 and the tissue transport channel 204 before reaching the first of three manifold element barrels or bores 128 .
- the entering tissue then engages barrel inlet 208 of the first syringe barrel 124 where it is at least partially directed or urged into the first of three syringe barrels 124 .
- the entering tissue is also urged downward into a particular syringe barrel 124 by gravity. Some tissue may also travel through a manifold element barrel 128 directly toward a downstream manifold output structure 105 .
- Some tissue will travel down into syringe barrel 124 , change direction and travel up within manifold element barrel 128 until engaging barrel outlet 212 , wherein it will be directed toward manifold output structure 105 .
- the combination of barrel inlet 208 and barrel outlet 212 serve to, among other things, slow the flow of the tissue, akin to a “speed bump” on a roadway.
- the manifold structure 104 includes an interior pathway or tissue transport channel 204 that extends from the inlet orifice 136 to the outlet orifice 140 .
- the tissue transport channel 204 includes features that promote the deposition of tissue into the syringe barrels 124 .
- each manifold element 108 includes a barrel inlet 208 that is offset from a barrel outlet 212 .
- the barrel inlet 208 of any one manifold element 108 is vertically offset from the barrel outlet 212 of the manifold element 108 .
- the barrel inlet 208 can be horizontally offset from the associated barrel outlet 212 , or the barrel inlet 208 can be both vertically and horizontally offset from the associated barrel outlet 212 .
- an additional barrier structure such as a barrier wall, can be provided to create a circuitous or lengthened path between a barrel inlet 208 and a barrel outlet 212 .
- the manifold element barrel 128 is configured with a plate or other means or geometry so there is no straight line path between an entry to manifold element barrel 128 and an exit from manifold element barrel 128 .
- the manifold element barrel 128 is configured with a plate, wall or other means or geometry around which material entering the manifold element 108 must flow before exiting manifold element 108 , to encourage the depositing of material into the syringe barrel 124 .
- FIGS. 5A-B illustrate a front perspective view, and a left side cross-sectional elevation view, respectively, of the modular tissue collection apparatus in accordance with another embodiment of the present invention.
- the embodiment of FIGS. 5A-B comprises a syringe plunger 132 associated with each syringe barrel 124 and is configured with a plurality of manifold elements 108 and associated syringe barrels 124 , syringe caps 144 and syringe plungers 132 .
- a series of four sets of manifold elements 108 are shown.
- a first manifold cap with inlet orifice 136 connects with tubing (not shown) which in turn is engaged with a source of tissue.
- An outlet manifold cap 116 connects with a vacuum source (not shown) via outlet orifice 140 .
- tissue As tissue enters inlet orifice 136 it enters the first of four manifold input structures 112 before reaching the first manifold element barrel or bore 128 . The tissue then enters barrel inlet 208 where it is at least partially directed or urged into the first of four syringe barrels 124 . Some tissue may also travel through manifold element barrel 128 directly toward manifold output structure 105 . Some tissue will travel down into syringe barrel 124 , change direction and travel up within manifold element barrel 128 until engaging barrel outlet 212 , wherein it will be directed toward manifold output structure 105 .
- the coupler 120 of each manifold element can be configured to receive the finger flanges 224 or other structure of the syringe barrel 124 .
- the finger flanges 224 of syringe barrel can be received in a slotted tab of the coupler 120 , forming a bayonet type attachment.
- An o-ring or other seal 228 can be included at the end of the manifold element barrel 128 , to provide an air tight seal between the manifold element 108 and the syringe barrel 124 .
- FIG. 6A is a perspective view of a manifold element 108 comprising a manifold input structure 104 , a manifold output structure 105 , a manifold element barrel 128 , a barrel inlet 208 and an inlet aperture 216 in accordance with embodiments of the present invention.
- the coupler 120 can be seen to include a pair of slotted tabs 304 for receiving the finger flanges of a syringe barrel 124 .
- FIG. 6B is a perspective view of a manifold element 108 comprising a manifold input structure 104 , a manifold output structure 105 , a manifold element barrel 128 , a barrel inlet 208 and an inlet aperture 216 in accordance with other embodiments of the present invention.
- the manifold element 108 in this alternative embodiment includes an attachment element 404 , for interconnecting the apparatus 100 to a support stand or structure.
- the example manifold element 108 of FIG. 6B can also feature a finger flange 408 , to facilitate the insertion of a syringe plunger 132 into the manifold element barrel 128 .
- a first or inlet manifold cap 112 is illustrated in FIG. 7 .
- the inlet orifice 136 may incorporate or be associated with a tip configured to receive a flexible vacuum tube.
- the inlet orifice 136 can comprise a Luer lock or other structure for positively interconnecting a vacuum tube to the apparatus 100 .
- the second or outlet manifold cap 116 can appear similar to the inlet manifold cap 112 , except that it is dimensioned to attach to the outlet aperture end of a manifold element 108 .
- any number of manifold elements 108 can be included in a tissue collection assembly 100 as described herein.
- each manifold element 108 within a particular manifold structure 104 may be identical to any other manifold element 108 within that structure.
- a medical practitioner or other user can select the number of manifold elements 108 , and thus the number of syringe barrels 124 , based on the volume of tissue to be collected and/or transferred during a procedure.
- the syringe barrel 124 sizes can be selected.
- the sizes of various features of the manifold elements 108 and of the syringe plungers 132 can be varied to match corresponding features of the syringe barrel 124 .
- syringe barrels 124 with capacities of from 10 cc to 200 cc can be utilized.
- the number of manifold elements 108 to be included within the device 100 is selectable.
- the selected number of manifold elements are then joined together, a first manifold cap 112 is placed over the inlet aperture 204 of the first manifold element 108 , and a second manifold cap 116 is placed over the outlet aperture 220 of the last manifold element 108 of the structure 104 .
- a syringe barrel 124 is connected to the coupler 120 , and, in one embodiment, a syringe 132 is placed within the manifold element barrel 128 , or each manifold element 108 .
- the inlet orifice 136 of the first manifold cap can then be connected to a tissue source, while the outlet orifice 140 of the second manifold cap can be connected to a vacuum source.
- a vacuum created by the vacuum source can then be used to draw tissue through the inlet orifice 136 , into the manifold assembly 104 .
- the tissue source can include a deposit of fat within a patient, and tissue comprising fat can be drawn from the patient using a cannula connected to the inlet orifice 136 by a length of vacuum tubing.
- tissue As collected tissue is drawn from the inlet orifice 136 , towards the outlet orifice 140 , the tissue is drawn through the barrel inlet 208 of the first manifold element 108 . Gravity then causes at least some of the tissue to drop into the syringe barrel 124 attached to the first manifold element 108 . In accordance with embodiments of the present invention, the deposition of tissue in the syringe barrel 124 is promoted by the offset between the the barrel inlet 208 and the barrel outlet 212 .
- any additional tissue will be drawn across the top of the syringe barrel 124 , out the barrel outlet 212 , and to the barrel inlet 208 of the next manifold element 108 (if provided).
- the application of vacuum by the vacuum source can be discontinued.
- the syringe barrel 124 can then be disconnected from the coupler 120 , for example by rotating the syringe barrel 124 by 90 degrees, and the syringe barrel 124 can be moved so as to draw the syringe barrel 124 down the manifold barrel 128 , until it is free from the manifold element 108 .
- the tip 144 can then be removed and, if desired, a needle can be attached to the syringe barrel 124 , to enable injection of the collected tissue into the patient.
- the syringe plunger 132 can be pushed towards an associated syringe barrel 124 , down the manifold barrel 128 in which the syringe plunger 132 is received, until the syringe plunger 132 has entered the syringe barrel 124 .
- all or portions of the device are manufactured using 3-D printing techniques. In another embodiment, all or portions of the device are made by injection molding techniques.
- Examples A1-4 depict one example construction of one embodiment of the invention in drawings each to scale. Dimensions are in inches. More specifically, Example A1 illustrates a top plan view, Example A2 a left side elevation view, and Example A3 a rear elevation view of an example construction of a particular embodiment of the modular tissue collection apparatus. Example A4 illustrates a left side elevation view of the syringe element of an example construction of a particular embodiment of the modular tissue collection apparatus of Example A1.
- embodiments of the present invention provide a convenient means by which tissue collected from a patient can be loaded into one or more syringes, ready for processing and/or reinjection to the patient. Moreover, the collected tissue is protected from contact with the ambient air and/or potential contaminants.
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Abstract
Description
- This application is a continuation of U.S. patent application Ser. No. 14/078,333, filed Nov. 12, 2013, which claims the benefit of U.S. Provisional Application No. 61/725,262, filed Nov. 12, 2012, the entire disclosures of which are hereby incorporated herein by reference in their entirety.
- A syringe fill method and apparatus are disclosed. More particularly, a modular system and method for filling one or more syringes with tissue, including but not limited to fat, in connection with tissue transfer operations are disclosed.
- Microlipoinjection is a process in which fat is taken by a cannula from one spot in the body and reinjected in another place in the body. Microlipoinjection has also been known as liposuction with fat transfer, fat grafting or fat transplantation. In general, microlipoinjection is performed to treat divots and scar indentations from trauma to the face or body, such as may occur as a secondary effect of domestic trauma, surgery or infection. Microlipoinjection can also be used to treat the effects of the loss of the subcutaneous layer of fat due to the normal aging process, either alone or in combination with facelift and fat grafting techniques. Other uses for microlipoinjection include providing filler to reapproximate weakened vocal cords, filling sinuses, or partially closing incompetent valves.
- In addition, every mass of fat in the human body has with it a varying number of adult stem cells. These stem cells are the precursor to healthy fat cells, and also have a limited ability to differentiate into different tissue. When placed in fat they will divide several times into mature fat cells and more adult stem cells. These stem cells are an important part of a tissue harvest.
- Up to about 1990, there were few artificial filler substances available to surgeons. Accordingly, surgeons used human bone, collagen and fat as fillers. However, the use of fat was not very successful, because the instruments and techniques were not sufficiently refined. For example, 50% of the fat may not have lived through the transplantation process. As a result, surgeons would need to implant more fat than would be required if all of the fat survived the process, or the transplantation process would have to be repeated multiple times or both.
- More recently, a number of filler substances, such as Restylane Hyaluronic Acid, Collagen, Fibril, ePTFE (Teflon®), Hylan B Gel, Artecol, BioBlastique and have been used. These substances have proved effective at filling small areas, but the cost for larger areas has become prohibitive. For this reason, as well as interest in the “natural substance” concept, surgeons and their patients have again looked at using fat as a filler.
- With the renewed interest in using fat as a filler, techniques have been refined to provide a better fat graft “take” with revascularization. However, the instruments and devices conventionally available to perform the procedure remain clumsy and ill-suited for the procedure. For example, conventional systems for transferring fat or other tissue removed from one location in a patient's body to a syringe for reinjection in another location in the patient's body can require multiple steps, expose the tissue to the ambient air, create waste and mess, and are inconvenient.
- Embodiments of the disclosed invention are directed to solving these and other problems and disadvantages of the prior art. In accordance with embodiments of the disclosed invention, a modular collection apparatus is provided. The apparatus features a manifold structure. The manifold structure includes one or more manifold elements. Each manifold element has a coupler for interconnecting a syringe body to the manifold element, optionally includes a barrel or bore for receiving a syringe plunger aligned with the syringe body, an inlet, and an outlet. A barrel inlet and a barrel outlet can also be incorporated, with the barrel inlet offset from the barrel outlet to promote the deposition of tissue into the barrel or body of an attached syringe. A first manifold cap that includes a connector for interconnecting the apparatus to a source of tissue can be joined to the inlet of a first manifold element. A second manifold cap that includes a connector for interconnecting the apparatus to a vacuum source can be joined to the outlet of the last manifold element. In accordance with further embodiments of the present invention, a method for depositing collected tissue into one or more syringes are provided. More particularly, one or more manifold elements and a syringe barrel associated with each of the manifold elements are joined to a source of tissue by a first manifold cap, and to a vacuum source by a second manifold cap. Tissue is drawn through the inlet by a vacuum from the vacuum source. The tissue may be obtained from a patient using a cannula attached to the first manifold cap by a length of flexible tubing. At least some tissue drawn in through the first manifold cap is deposited in a first syringe barrel attached to a first manifold element. The deposition of tissue in the first syringe barrel can be encouraged through the provision of a barrier or wall that prevents the collected tissue from being drawn across the top of the syringe barrel unimpeded. Once the first syringe barrel is full of tissue, any additional tissue drawn in to the apparatus is drawn to a second manifold element and associated syringe barrel (if provided). Accordingly, multiple syringe barrels can be filled sequentially. Once a desired amount of tissue has been collected, the vacuum source can be turned off or disconnected, and the syringe barrel associated with a first manifold element can then be disconnected from the first manifold element. The tissue in the syringe can then be injected into the patient through a needle or cannula attached to the syringe barrel, at the urging of a plunger inserted into the barrel, or deposited into another receptacle for processing.
- Additional features and advantages of embodiments of the present invention will become more readily apparent from the following discussion, particularly when taken together with the accompanying drawings.
-
FIG. 1 illustrates a front perspective view of the modular tissue collection apparatus in accordance with an embodiment of the disclosed invention; -
FIG. 2A is a top plan view of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 2B is a left side elevation view of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 2C is a rear elevation view of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 2D is a left side elevation view of the syringe element of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 2E is a left side elevation view of another embodiment of the syringe element of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 2F is a cross-sectional view of section A-A ofFIG. 2B ; -
FIG. 2G is a cross-sectional view of section B-B ofFIG. 2B ; -
FIG. 3A is a front perspective view of a manifold element of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 3B is a rear perspective view of a manifold element of the modular tissue collection apparatus of the embodiment ofFIG. 1 ; -
FIG. 4A is a top plan view of the modular tissue collection apparatus in accordance with another embodiment of the present invention; -
FIG. 4B is a left side partial cross-sectional elevation view of the modular tissue collection apparatus of the embodiment ofFIG. 4A ; -
FIG. 5A is a front perspective view of the modular tissue collection apparatus in accordance with another embodiment of the present invention; -
FIG. 5B is a left side cross-sectional elevation view of the modular tissue collection apparatus of the embodiment ofFIG. 5A ; -
FIG. 6A is a perspective view of a manifold element in accordance with an embodiment of the present invention; -
FIG. 6B is a perspective view of a manifold element in accordance with another embodiment of the present invention; -
FIG. 7 is a perspective view of a manifold cap in accordance with an embodiment of the present invention; -
FIG. 8 illustrates a top plan view of an example construction of a particular embodiment of the modular tissue collection apparatus—the drawing is to scale with dimensions in inches; -
FIG. 9 illustrates a left side elevation view of an example construction of a particular embodiment of the modular tissue collection apparatus ofFIG. 8 —the drawing is to scale with dimensions in inches; -
FIG. 10 illustrates a rear elevation view of an example construction of a particular embodiment of the modular tissue collection apparatus ofFIG. 8 —the drawing is to scale with dimensions in inches; and -
FIG. 11 illustrates a left side elevation view of the syringe element of an example construction of a particular embodiment of the modular tissue collection apparatus ofFIG. 8 —the drawing is to scale. - A modular tissue collection system or
apparatus 100 in accordance with embodiments of the disclosed invention is illustrated in elevation inFIG. 1 . Theapparatus 100 features amanifold element 108 comprising acoupler 120, manifold barrel or bore 128,manifold input structure 104 and an opposingmanifold output structure 105. Themanifold input structure 104 connects with a first orinlet manifold cap 112 comprising aninlet orifice 136. Themanifold output structure 105 connects with a second or outletmanifold cap 116 comprising anoutlet orifice 140. In one embodiment, each of these two afore-mentioned connections are interference fits. Each of themanifold input structure 104 andmanifold output structure 105 engage acoupler 120 to which a syringe body orbarrel 124 is connected, at least while the apparatus in an assembled state. Eachmanifold element 108 also includes aplate 122 which may be used, for example, to mount or secure the modulartissue collection apparatus 100 to, for example, a “universal stand” as typical in health care environments. An aperture may optionally be included on theplate 122 itself or proximal to theplate 122, such as on a connecting element between theplate 122 and themanifold element 108, to engage a chain or similar to secure the modulartissue collection apparatus 100. - With a
syringe barrel 124 connected to eachmanifold element 108, the apparatus is sealed from aninlet orifice 136 at thefirst manifold cap 112 to anoutlet orifice 140 at thesecond manifold cap 116. In a preferred embodiment, when tissue is being collected, theinlet orifice 136 can be connected to a tissue source, for example through a length of flexible tubing and a cannula, and theoutlet orifice 140 can be connected to a vacuum source. In another less-preferred embodiment, the tissue flow is reversed, i.e. theoutlet orifice 140 can be connected to a tissue source, for example through a length of flexible tubing and a cannula, and theinlet orifice 136 can be connected to a vacuum source. Also, eachsyringe barrel 124 can be sealed at a tip end by asyringe cap 144, such that theapparatus 100 is completely sealed between theinlet orifice 136 and theoutlet orifice 140, at least when theapparatus 100 is configured for tissue collection. -
FIGS. 2A-C provide a top plan view, a left side elevation view, and a rear elevation view of the modular tissue collection apparatus of the embodiment ofFIG. 1 . As shown inFIGS. 2A-C , a modulartissue collection apparatus 100 comprises amanifold input structure 104 engaged with afirst manifold cap 112 comprising aninlet orifice 136. Theinlet orifice 136 is connected withtubing 150. Thetubing 150 may be any commercially available tubing as used, for example, in medical procedures. Thetubing 150 fits over aninlet orifice 136 as an interference fit. In other embodiments, thetubing 150 is clamped to theinlet orifice 136 or otherwise engaged so as to maintain a fluid seal. Themanifold output structure 105 engages anoutput manifold cap 116 comprising anoutlet orifice 140. Theoutlet orifice 140 connects to vacuum source (not shown) so as to create suction, or a negative pressure between theinlet orifice 136 and theoutlet orifice 140, thereby urging tissue into the modulartissue collection apparatus 100 via theinlet orifice 136. Thesyringe barrel 124, comprising asyringe cap 144, attaches to themanifold element 108 via acoupler 120. Thecoupler 120 includes two parallel tracks configured to receive the top of thesyringe barrel 124. In other embodiments, thecoupler 120 is any means to engage a syringe barrel as known to those skilled in the art, to include a complete or partial ring to enable an interference fit. -
FIG. 2D is a left side elevation view of thesyringe barrel 124 with asyringe plunger 132. In one embodiment, thesyringe barrel 124 and/or thesyringe plunger 132 are any designs as commercially available. In another embodiment, a distal end of thesyringe plunger 132 comprises an outer radial portion, such as a gasket or o-ring, which provides a more secure fit or seal than that typically commercially available. More specifically, an outer radial portion that maintains a fluid seal when receiving a pressure as great as 29.92 inHg (i.e. 1 atm). In another embodiment, the outer radial portion maintains a fluid pressure up to 20 inHg. In another embodiment, the outer radial portion maintains a fluid pressure of approximately 15 inHg -
FIG. 2E is a left side elevation view of another embodiment of thesyringe barrel 124 with asyringe plunger 132. In the embodiment ofFIG. 2E , thesyringe plunger 132 is specially configured to prevent and/or avoid waste. More particularly, rather than featuring a conventional plunger tip, ahollow tip 133 portion is provided. The volume of thehollow tip 133 allows tissue at the top of thesyringe barrel 124 to be trapped, rather than displaced, when theplunger 132 is moved down themanifold element barrel 128, into thesyringe barrel 124. -
FIGS. 2F-G illustrate cross-sectional views of sections A-A and B-B, respectively, ofFIG. 2B . As shown inFIGS. 2F-G , the modulartissue collection apparatus 100 comprises themanifold element 108 comprising theinlet aperture 216 and thebarrel inlet 208, and theoutlet aperture 220 and thebarrel outlet 212. Thebarrel inlet 208 at least partially directs or urges incoming or received material, such as tissue, downward into thesyringe barrel 124. The vertical offset of thebarrel outlet 212 relative to thebarrel inlet 208 at least partially directs or urges incoming or received fluid, such as tissue, as received from theinlet orifice 136, to drop into thesyringe barrel 124. In some circumstances, for example after thesyringe barrel 124 is completely or partially full, thebarrel outlet 212 allows received material, such as tissue, to pass toward the outlet aperture. -
FIGS. 3A-B illustrate front perspective views of the modular tissue collection apparatus of the embodiment ofFIG. 1 . Themanifold element 108 comprises amanifold input structure 104, amanifold output structure 105 and acoupler 120. Themanifold input structure 104 surrounds aninlet aperture 216, with a distal diameter larger than a distal diameter of theoutlet aperture 220. Each of themanifold input structure 104 and themanifold output structure 105 taper in external diameter with distance from thecoupler 120. In one embodiment, the internal diameters of one or both of themanifold input structure 104 and themanifold output structure 105 similarly taper in diameter with distance from thecoupler 120. In another embodiment, each of themanifold input structure 104 and themanifold output structure 105 do not taper and are of constant diameter with distance from thecoupler 120. -
FIGS. 4A-B illustrate a top plan view, and a left side partial cross-sectional elevation view, respectively, of the modular tissue collection apparatus of the embodiment ofFIG. 1 as configured with a plurality ofmanifold elements 108 and associated syringe barrels 124. The embodiment ofFIGS. 4A-B is constructed of the modular components ofFIG. 1 . A series of three sets ofmanifold elements 108 with attached syringe barrels 124 is shown. A first manifold cap with aninlet orifice 136 connects withtubing 150 which in turn is engaged with a source of tissue. Anoutlet manifold cap 116 connects with a vacuum source (not shown) via anoutlet orifice 140. - The first
manifold element 108 may have aninlet aperture 216 that is joined to thefirst manifold cap 112, and anoutlet aperture 220 that is joined to either theinlet aperture 216 of a secondmanifold element 108, or to thesecond manifold cap 116. Accordingly, the manifold structure can be configured with from one to any number ofmanifold elements 108. Eachmanifold element 108 includes acoupler 120 to which a syringe body orbarrel 124 is connected, at least while the apparatus in an assembled state. With asyringe barrel 124 connected to eachmanifold element 108, the apparatus is sealed from aninlet orifice 136 at thefirst manifold cap 112 to anoutlet orifice 140 at thesecond manifold cap 116. When tissue is being collected, theinlet orifice 136 can be connected to a tissue source, for example through a length of flexible tubing and a cannula, and theoutlet orifice 140 can be connected to a vacuum source. Moreover, eachsyringe barrel 124 can be sealed at a tip end by asyringe cap 144, such that theapparatus 100 is completely sealed between theinlet orifice 136 and theoutlet orifice 140, at least when theapparatus 100 is configured for tissue collection. - As tissue enters
inlet orifice 136 it enters the first of threemanifold input structures 112 and thetissue transport channel 204 before reaching the first of three manifold element barrels or bores 128. The entering tissue then engagesbarrel inlet 208 of thefirst syringe barrel 124 where it is at least partially directed or urged into the first of three syringe barrels 124. The entering tissue is also urged downward into aparticular syringe barrel 124 by gravity. Some tissue may also travel through amanifold element barrel 128 directly toward a downstreammanifold output structure 105. Some tissue will travel down intosyringe barrel 124, change direction and travel up withinmanifold element barrel 128 until engagingbarrel outlet 212, wherein it will be directed towardmanifold output structure 105. The combination ofbarrel inlet 208 andbarrel outlet 212 serve to, among other things, slow the flow of the tissue, akin to a “speed bump” on a roadway. - The
manifold structure 104 includes an interior pathway ortissue transport channel 204 that extends from theinlet orifice 136 to theoutlet orifice 140. In addition, thetissue transport channel 204 includes features that promote the deposition of tissue into the syringe barrels 124. More particularly, eachmanifold element 108 includes abarrel inlet 208 that is offset from abarrel outlet 212. In the illustrated example, thebarrel inlet 208 of any onemanifold element 108 is vertically offset from thebarrel outlet 212 of themanifold element 108. In accordance with other embodiments, thebarrel inlet 208 can be horizontally offset from the associatedbarrel outlet 212, or thebarrel inlet 208 can be both vertically and horizontally offset from the associatedbarrel outlet 212. - In accordance with still other embodiments, an additional barrier structure, such as a barrier wall, can be provided to create a circuitous or lengthened path between a
barrel inlet 208 and abarrel outlet 212. That is, in one embodiment, themanifold element barrel 128 is configured with a plate or other means or geometry so there is no straight line path between an entry tomanifold element barrel 128 and an exit frommanifold element barrel 128. Stated another way, themanifold element barrel 128 is configured with a plate, wall or other means or geometry around which material entering themanifold element 108 must flow before exitingmanifold element 108, to encourage the depositing of material into thesyringe barrel 124. -
FIGS. 5A-B illustrate a front perspective view, and a left side cross-sectional elevation view, respectively, of the modular tissue collection apparatus in accordance with another embodiment of the present invention. The embodiment ofFIGS. 5A-B comprises asyringe plunger 132 associated with eachsyringe barrel 124 and is configured with a plurality ofmanifold elements 108 and associated syringe barrels 124, syringe caps 144 andsyringe plungers 132. A series of four sets ofmanifold elements 108 are shown. A first manifold cap withinlet orifice 136 connects with tubing (not shown) which in turn is engaged with a source of tissue. Anoutlet manifold cap 116 connects with a vacuum source (not shown) viaoutlet orifice 140. As tissue entersinlet orifice 136 it enters the first of fourmanifold input structures 112 before reaching the first manifold element barrel or bore 128. The tissue then entersbarrel inlet 208 where it is at least partially directed or urged into the first of four syringe barrels 124. Some tissue may also travel throughmanifold element barrel 128 directly towardmanifold output structure 105. Some tissue will travel down intosyringe barrel 124, change direction and travel up withinmanifold element barrel 128 until engagingbarrel outlet 212, wherein it will be directed towardmanifold output structure 105. - The
coupler 120 of each manifold element can be configured to receive thefinger flanges 224 or other structure of thesyringe barrel 124. For example, thefinger flanges 224 of syringe barrel can be received in a slotted tab of thecoupler 120, forming a bayonet type attachment. An o-ring orother seal 228 can be included at the end of themanifold element barrel 128, to provide an air tight seal between themanifold element 108 and thesyringe barrel 124. -
FIG. 6A is a perspective view of amanifold element 108 comprising amanifold input structure 104, amanifold output structure 105, amanifold element barrel 128, abarrel inlet 208 and aninlet aperture 216 in accordance with embodiments of the present invention. In this view, thecoupler 120 can be seen to include a pair of slottedtabs 304 for receiving the finger flanges of asyringe barrel 124. -
FIG. 6B is a perspective view of amanifold element 108 comprising amanifold input structure 104, amanifold output structure 105, amanifold element barrel 128, abarrel inlet 208 and aninlet aperture 216 in accordance with other embodiments of the present invention. More particularly, themanifold element 108 in this alternative embodiment includes anattachment element 404, for interconnecting theapparatus 100 to a support stand or structure. Theexample manifold element 108 ofFIG. 6B can also feature afinger flange 408, to facilitate the insertion of asyringe plunger 132 into themanifold element barrel 128. - A first or
inlet manifold cap 112 is illustrated inFIG. 7 . Theinlet orifice 136 may incorporate or be associated with a tip configured to receive a flexible vacuum tube. In accordance with at least some embodiments, theinlet orifice 136 can comprise a Luer lock or other structure for positively interconnecting a vacuum tube to theapparatus 100. In general, the second or outletmanifold cap 116 can appear similar to theinlet manifold cap 112, except that it is dimensioned to attach to the outlet aperture end of amanifold element 108. - As described herein, any number of
manifold elements 108 can be included in atissue collection assembly 100 as described herein. Moreover, eachmanifold element 108 within aparticular manifold structure 104 may be identical to any othermanifold element 108 within that structure. Accordingly, a medical practitioner or other user can select the number ofmanifold elements 108, and thus the number of syringe barrels 124, based on the volume of tissue to be collected and/or transferred during a procedure. In accordance with embodiments of the present disclosure, thesyringe barrel 124 sizes can be selected. As can be appreciated by one of skill in the art after consideration of the present disclosure, the sizes of various features of themanifold elements 108 and of thesyringe plungers 132 can be varied to match corresponding features of thesyringe barrel 124. As examples, but without limitation, syringe barrels 124 with capacities of from 10 cc to 200 cc can be utilized. - In use, the number of
manifold elements 108 to be included within thedevice 100 is selectable. The selected number of manifold elements are then joined together, afirst manifold cap 112 is placed over theinlet aperture 204 of the firstmanifold element 108, and asecond manifold cap 116 is placed over theoutlet aperture 220 of thelast manifold element 108 of thestructure 104. In addition, asyringe barrel 124 is connected to thecoupler 120, and, in one embodiment, asyringe 132 is placed within themanifold element barrel 128, or eachmanifold element 108. Theinlet orifice 136 of the first manifold cap can then be connected to a tissue source, while theoutlet orifice 140 of the second manifold cap can be connected to a vacuum source. A vacuum created by the vacuum source can then be used to draw tissue through theinlet orifice 136, into themanifold assembly 104. As an example, but without limitation, the tissue source can include a deposit of fat within a patient, and tissue comprising fat can be drawn from the patient using a cannula connected to theinlet orifice 136 by a length of vacuum tubing. - As collected tissue is drawn from the
inlet orifice 136, towards theoutlet orifice 140, the tissue is drawn through thebarrel inlet 208 of the firstmanifold element 108. Gravity then causes at least some of the tissue to drop into thesyringe barrel 124 attached to the firstmanifold element 108. In accordance with embodiments of the present invention, the deposition of tissue in thesyringe barrel 124 is promoted by the offset between the thebarrel inlet 208 and thebarrel outlet 212. Once thefirst syringe barrel 124 is full of tissue, any additional tissue will be drawn across the top of thesyringe barrel 124, out thebarrel outlet 212, and to thebarrel inlet 208 of the next manifold element 108 (if provided). - Once all or a desired number of syringe barrels 124 have been filled with tissue, either entirely or at least to a desired amount, the application of vacuum by the vacuum source can be discontinued. The
syringe barrel 124 can then be disconnected from thecoupler 120, for example by rotating thesyringe barrel 124 by 90 degrees, and thesyringe barrel 124 can be moved so as to draw thesyringe barrel 124 down themanifold barrel 128, until it is free from themanifold element 108. Thetip 144 can then be removed and, if desired, a needle can be attached to thesyringe barrel 124, to enable injection of the collected tissue into the patient. In the embodiment of the modulartissue collection apparatus 100 comprising asyringe plunger 132, after the vacuum source is discontinued, thesyringe plunger 132 can be pushed towards an associatedsyringe barrel 124, down themanifold barrel 128 in which thesyringe plunger 132 is received, until thesyringe plunger 132 has entered thesyringe barrel 124. - In one embodiment of the device, all or portions of the device are manufactured using 3-D printing techniques. In another embodiment, all or portions of the device are made by injection molding techniques.
- Although well suited for use in human patients, and although much of the discussion of the present invention is directed toward use involving humans and human tissue, advantages offered by the present invention may be realized in the veterinary and scientific fields for the benefit and study of all types of animals and biological systems.
- Without intending to limit the scope of the invention, Examples A1-4 depict one example construction of one embodiment of the invention in drawings each to scale. Dimensions are in inches. More specifically, Example A1 illustrates a top plan view, Example A2 a left side elevation view, and Example A3 a rear elevation view of an example construction of a particular embodiment of the modular tissue collection apparatus. Example A4 illustrates a left side elevation view of the syringe element of an example construction of a particular embodiment of the modular tissue collection apparatus of Example A1.
- To provide further clarity to the Detailed Description provided herein in the associated drawings, the following list of components and associated numbering are provided as follows:
-
# Component 100 Apparatus 104 Manifold Input Structure 105 Manifold Output Structure 108 Manifold Element 112 First Manifold Cap 116 Outlet Manifold Cap 120 Coupler 122 Plate 124 Syringe Barrel 128 Manifold Element Barrel or Bore 132 Syringe Plunger 133 Hollow Tip 136 Inlet Orifice 140 Outlet Orifice 144 Syringe Cap 150 Tubing 204 Tissue Transport Channel 208 Barrel Inlet 212 Barrel Outlet 216 Inlet Aperture 220 Outlet Aperture 224 Finger Flanges 228 Seal 304 Slotted Tabs 404 Attachment Element 408 Finger Flange - As can be appreciated by one of skill in the art from the present description, embodiments of the present invention provide a convenient means by which tissue collected from a patient can be loaded into one or more syringes, ready for processing and/or reinjection to the patient. Moreover, the collected tissue is protected from contact with the ambient air and/or potential contaminants.
- The foregoing discussion of the invention has been presented for purposes of illustration and description. Further, the description is not intended to limit the invention to the form disclosed herein. Consequently, variations and modifications commensurate with the above teachings, within the skill or knowledge of the relevant art, are within the scope of the present invention. The embodiments described hereinabove are further intended to explain the best mode presently known of practicing the invention and to enable others skilled in the art to utilize the invention in such or in other embodiments and with various modifications required by the particular application or use of the invention. Features of the invention, such as those disclosed in the embodiments presented, may be combined or eliminated to disclose alternate embodiments of the invention. It is intended that the appended claims be construed to include alternative embodiments to the extent permitted by the prior art.
Claims (20)
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US9468709B2 (en) | 2016-10-18 |
US20140130936A1 (en) | 2014-05-15 |
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