US20150135729A1 - Device for stimulating adaptive thermogenesis in brown adipose tissue - Google Patents
Device for stimulating adaptive thermogenesis in brown adipose tissue Download PDFInfo
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- US20150135729A1 US20150135729A1 US14/607,784 US201514607784A US2015135729A1 US 20150135729 A1 US20150135729 A1 US 20150135729A1 US 201514607784 A US201514607784 A US 201514607784A US 2015135729 A1 US2015135729 A1 US 2015135729A1
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/002—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches with controlled internal environment
- A41D13/005—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches with controlled internal environment with controlled temperature
- A41D13/0053—Cooled garments
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D1/00—Garments
- A41D1/04—Vests, jerseys, sweaters or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/10—Cooling bags, e.g. ice-bags
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D5/00—Devices using endothermic chemical reactions, e.g. using frigorific mixtures
- F25D5/02—Devices using endothermic chemical reactions, e.g. using frigorific mixtures portable, i.e. adapted to be carried personally
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0009—Throat or neck
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0029—Arm or parts thereof
- A61F2007/003—Shoulder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0292—Compresses or poultices for effecting heating or cooling using latent heat produced or absorbed during phase change of materials, e.g. of super-cooled solutions
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Thermal Sciences (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mechanical Engineering (AREA)
- Combustion & Propulsion (AREA)
- General Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
Abstract
Description
- This application claims priority from U.S. Provisional Application No. 61/318,990, which was filed on Mar. 30, 2010, which has the same title, and which is incorporated herein by reference in its entirety.
- The present disclosure relates generally to devices for exercise, physical therapy or weight loss, and more particularly to a garment adapted to stimulate adaptive thermogenesis in brown adipose tissues.
- It is often desirable for athletes or individuals undergoing training, physical therapy, or a weight loss regimen to include resistance in an exercise or therapy session. To this end, various devices and types of wearing apparel have been developed over the years that incorporate weight into their designs. By inclusion of weight into the garment itself, the wearer can enjoy the benefits of weight resistance without the inconvenience associated with ankle weights, dumbbells, sandbags and other such separate accessories.
- One example of a garment of the foregoing type is disclosed in U.S. Pat. No. 5,144,694 (Daoud et al.), entitled “Exercise Apparel and Weight Packets”. The garment disclosed therein includes a vest, pants, spine strap, belt, wrist bands, ankle bands and weight packets. The weight packets include plural rows and plural columns of weight members that are installed in pockets, and the pockets are positioned to distribute the weights about the wearer's body. The placement of the weights is solely maintained by the snugness of the garment's fit to the wearer's body.
- Another example of the foregoing type of garment is the exercise vest described in U.S. Pat. No. 5,937,441 (Raines). This weighted exercise and therapeutic vest, when worn by a person involved in either athletic training, physical therapy or a weight reduction program, enhances the benefits of the activity undertaken. The vest has a snug, form-fitting design that clings snugly to the wearer's body, and may be constructed with pockets or other receptacles into which weights may be inserted.
- The vest described in Raines represents a notable improvement in the art over previously known exercise vests in that its unique construction provides sufficient support to the applied weights to fix their placement relative to the wearer. This is accomplished through (a) the use of material that resists stretch in one direction while facilitating stretch in another; (b) the inclusion of support straps as an integral component of the vest's construction that join one or more weight compartments in which the weight packets are contained (by continuously connecting the strap to the vest along the entire length of the strap, the load of the weight packet may be distributed across the body of the vest); and (c) the utilization of a rubberized coating applied to at least portions of different components that are positioned into face-to-face engagement during use (the friction experienced between the two rubberized surfaces resists slippage of the weighted portions with respect to the suit and the body of the person wearing it).
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FIG. 1 is an illustration of a first particular, non-limiting embodiment of an exercise or therapeutic garment/device in accordance with the teachings herein. -
FIGS. 2-3 are illustrations of a second particular, non-limiting embodiment of an exercise or therapeutic garment/device in accordance with the teachings herein. -
FIG. 4 is an illustration of some particular, non-limiting embodiments of cooling packs which may be utilized in the garments and devices described herein. -
FIGS. 5-8 are illustrations of a third particular, non-limiting embodiment of an exercise or therapeutic garment/device in accordance with the teachings herein. -
FIGS. 9-12 are illustrations of a fourth particular, non-limiting embodiment of an exercise or therapeutic garment/device in accordance with the teachings herein. - Although the device of U.S. Pat. No. 5,937,441 (Raines) represents a notable advance in the art, this device was designed primarily as a weight-bearing vest for exercise or therapy, and hence does not address other needs of users. In particular, while such a device may be used to achieve weight loss in the same manner that any other type of exercise device may be utilized for that purpose, it does not, for example, directly enhance the underlying physiological processes that contribute to weight loss and enhance physical fitness. There is thus a need in the art for devices and methodologies which address this infirmity.
- It has now been found that the aforementioned needs may be met through the provision of a garment, apparel or other device which permits the thermal stimulation of brown adipose tissues in the body of the user. Such tissues are concentrated, for example, beneath the collar bones, the neck, upper spine, and armpit. Research suggests that it is possible to stimulate adaptive thermogenesis (that is, the generation of energy that the body uses in maintaining a normal body temperature) in such tissues within just 2 hours in a 60° F. room. The devices and methodologies disclosed herein make advantageous use of this discovery by using embedded or incorporated thermo-regulating devices, such as cooling packs, to maintain the brown adipose tissues of a user in a state conducive to adaptive thermogenesis. By way of example, an exercise vest or garment may be made in accordance with the teachings herein which has cooling packs incorporated into a portion thereof that extends over the collar bones, the neck, upper spine, and armpits of the user. The cooling packs may be selected, for example, to maintain a temperature of 58° F. for 3 to 4 hours, and are held snugly in place by the construction of the vest. Various cooling packs offering differing levels of coolness may be selected as thermo-regulating inserts or may be built into the garment.
- Studies in animals indicate that brown adipose tissue is important in the regulation of body weight. Indeed, it is possible that individual variations in adaptive thermogenesis can be attributed to variations in the amount or activity of brown adipose tissue. Until recently, the presence of brown adipose tissue was thought to be relevant only in small mammals and infants, and was believed to be of negligible physiologic relevance in adult humans. However, recent research reported in the New England Journal of Medicine (Wouter et al., “Cold Activated Brown Adipose Tissue in Healthy Men, N. Engl. J. Med. 360:15 (Apr. 9, 2009)) suggests that brown adipose tissue may be metabolically important, and the fact that it is reduced yet present in most overweight or obese subjects may make it the target for the treatment of obesity.
- The devices and methodologies disclosed herein make advantageous use of the foregoing findings by providing a means to thermally regulate brown adipose tissues in a subject during a workout or therapy session. In particular, the devices and methodologies disclosed herein provide a means by which the brown adipose tissues (as well as surrounding tissues, fluids, or other body masses) in a user may be subjected to a cooling effect which is believed to be advantageous for achieving weight loss through adaptive thermogenesis.
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FIG. 1 depicts a first particular, non-limiting embodiment of a thermogenetic garment made in accordance with the teachings herein. Thegarment 180 depicted therein is an exercise vest which is similar in many respects to the vest disclosed in U.S. Pat. No. 5,937,441 (Raines), which is incorporated herein by reference in its entirety. Thus, thegarment 180 comprises anupper portion 178 that extends over the collar bones of the user, and alower portion 184 that extends across the chest of the user. The material of theupper portion 178 is preferably constructed to permit stretching in lateral or horizontal directions, but to resist vertical stretching. Theupper portion 178 has embedded therein one or more cooling packs (which may comprise, for example, one or more materials that undergo a phase change) which are adapted to provide a cooling effect to the collar bone area of the user. Preferably, the cooling packs are adapted to maintain a temperature of 58° F. for 3 to 4 hours. However, it will be appreciated that various materials (including solids, liquids, or gas) may be selected for this purpose that provide a cooling effect which is characterized by different durations and temperatures (or ranges of temperatures). The duration of cooling and the characteristic temperature or temperature range may be chosen based on the desired application. - The
garment 180 in this particular embodiment has alower portion 181 which is optionally equipped with a plurality ofcooling pack pockets 182 or other thermo-regulating devices that are arranged generally about a lower portion of thegarment 180. The specific configuration of thecooling pack pockets 182 may vary from one embodiment to another. Each of thecooling pack pockets 182 may have a cooling pack inserted therein, with the number of cooling packs andcooling pack pockets 182 utilized being chosen to achieve a desired cooling effect for the vest. - To facilitate use of the vest, a
zipper 181 is provided at the front-center of thegarment 180. A plurality ofloops 183 are also provided at the sides of thegarment 180 to further assure that thegarment 180 fits snuggly and is variably adjustable. Theloops 183 receive acinch string 185 that may be tightened or loosened to accommodate the particular wearer's body size and to customize the fit of thegarment 180. - The
garment 180 in this particular embodiment may be further equipped with a set ofoptional anchor straps 187 to anchor the weightedgarment 180 against upward movement with respect to the wearer. Alligator-type clips 189 are provided at terminal lower ends of theanchor straps 187 for releasably fixing thestraps 187 to another article of clothing of the wearer. By way of example, theseclips 189 may be used to clip theanchor straps 187 to the waistband of a pair of shorts or pants. Of course, it will be appreciated that thegarment 180 is not limited to the use of the foregoingclips 189 andstraps 187, and that other suitable means may be utilized that achieve a similar end. -
FIGS. 2-3 depict a second particular, non-limiting embodiment of a thermogenetic garment made in accordance with the teachings herein. Thegarment 201 depicted therein comprises alower portion 203, anupper portion 205 and a zipper 207 (seeFIG. 2 ) which bisects thegarment 201 along a vertical axis. Theupper portion 205 is equipped with a plurality ofcompartments 209, each of which is designed to hold a thermo-regulating device 211 (seeFIG. 4 ). Thesecompartments 209 may be permanently sealed, or may be equipped with a zipper or fastener to allow the thermo-regulating devices 211 to be inserted, removed or replaced. Theupper portion 205 of thegarment 201 comprises an inner portion 213 which is preferably equipped with a cooling gel layer, and an outer portion 215 which includes thecompartments 209. - The
lower portion 203 of thegarment 201 may have a construction which is the same as, or different from, theupper portion 205. For example, in some embodiments, thelower portion 203 of thegarment 201 may also be equipped with a plurality ofcompartments 209 designed to hold thermo-regulating devices 211. Alternatively, thecompartments 209 in thelower portion 203 may be used to hold weights or a material, such as sand or metal particles, which add weight or resistance to thegarment 201. - Various materials may be used in the construction of the
garment 201. Preferably, the garment is equipped with a base material comprising a one-way stretch fabric, such as the fabrics based on polyurethane-polyurea copolymers sold under the trade names LYCRA® and SPANDEX®. The garment is also preferably equipped with a top or outer material which preferably comprises one or more synthetic rubbers. Suitable materials of this type include the fabrics based on polychloroprene which are sold under the trade name NEOPRENE®. -
FIG. 4 illustrates some particular, non-limiting examples of thermo-regulating devices 211 which may be utilized in the garment ofFIGS. 2-3 . These devices, which may be the same as or different from the cooling packs described with respect to the embodiment ofFIG. 1 , are designed to fit inside of suitably sized pockets provided in theupper portion 205 of thegarment 201, and are preferably designed to lay flat against the body of the user. The thermo-regulating devices may be custom shaped (see 211 a), and may have a single compartment (see 211 b) or multi-compartment (see 211 c) structure. Moreover, while the thermo-regulating devices are preferably adapted to provide a cooling effect, embodiments are also possible in which these devices provide a heating effect. -
FIGS. 5-8 illustrate another particular, non-limiting embodiment of a thermogenetic garment made in accordance with the teachings herein. Thegarment 301 depicted therein comprises alower portion 303 that extends over the neck and shoulder blades of the user, and anupper portion 305 that extends around the neck of the user. Aseam 307 equipped with a hook and loop type faster, zipper, or other suitable releasable fastener is provided to allow thegarment 301 to be readily positioned on, or removed from, the body of the user. - As shown in
FIGS. 7-8 , in some variations of this embodiment, anauxiliary portion 319 is provided which extends across the armpits of the user. Preferably, theauxiliary portion 319 is releasably attached to thegarment 301 by way of a hook-and-loop type fastener 308, although it will be appreciated that a zipper or other suitable means as are known to the art may be utilized to releasably attach theauxiliary portion 319 to thelower portion 303 of thegarment 301. However, embodiments are also contemplated where theauxiliary portion 319 is permanently attached to thegarment 301. - The
garment 301 may have the same general construction as thegarment 201 depicted inFIGS. 2-3 . Like thatgarment 201, thegarment 301 is equipped with one ormore compartments 309 which contain a thermo-regulating devices. -
FIGS. 9-12 illustrate a further particular, non-limiting embodiment of a thermogenetic garment made in accordance with the teachings herein. Thegarment 401 depicted therein comprises alower portion 403 that extends across the shoulder blades and spine of the user, and anupper portion 405 that extends around the neck of the user. As seen inFIG. 10 , aseam 408 equipped with a hook and loop type faster, zipper, or other suitable releasable fastener is provided to allow thegarment 401 to be readily positioned on, or removed from, the body of the user.FIGS. 11 and 12 show alternate variations of this embodiment in which theseam 408 is positioned in different areas of thegarment 401. - While the foregoing description has focused primarily on the adaptation of a garment to stimulate adaptive thermogenesis by applying a cooling effect to brown adipose tissues occurring in the collar bone area, the neck, the upper spine, and the armpit of the user, one skilled in the art will appreciate that, more generally, garments may be made in accordance with the teachings herein which are adapted to apply a cooling effect to brown adipose tissues wherever they may occur in the body of the user. In some such embodiments, the cooling effect may be localized to the brown adipose tissues, though embodiments are also possible in accordance with the teachings herein which apply such an effect to a larger area, or even to the entire body of the user.
- The above description of the present invention is illustrative, and is not intended to be limiting. It will thus be appreciated that various additions, substitutions and modifications may be made to the above described embodiments without departing from the scope of the present invention. Accordingly, the scope of the present invention should be construed in reference to the appended claims.
Claims (21)
Priority Applications (1)
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US14/607,784 US20150135729A1 (en) | 2010-03-30 | 2015-01-28 | Device for stimulating adaptive thermogenesis in brown adipose tissue |
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US31899010P | 2010-03-30 | 2010-03-30 | |
US13/076,325 US8950207B2 (en) | 2010-03-30 | 2011-03-30 | Device for stimulating adaptive thermogenesis in brown adipose tissue |
US14/607,784 US20150135729A1 (en) | 2010-03-30 | 2015-01-28 | Device for stimulating adaptive thermogenesis in brown adipose tissue |
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US5755110A (en) * | 1996-09-26 | 1998-05-26 | Silvas; Cesar F. | Cooling vest with elongated strips containing a polymer absorbing material |
US5970519A (en) | 1998-02-20 | 1999-10-26 | Weber; Stanley | Air cooling garment for medical personnel |
US6185742B1 (en) * | 1998-10-23 | 2001-02-13 | Brian Doherty | Cool garment |
US6972029B2 (en) * | 2002-10-10 | 2005-12-06 | Patricia Mayrhofer | Healing garment |
-
2011
- 2011-03-30 US US13/076,325 patent/US8950207B2/en active Active
- 2011-10-07 US US13/269,280 patent/US8800311B2/en active Active
-
2015
- 2015-01-28 US US14/607,784 patent/US20150135729A1/en not_active Abandoned
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US4658442A (en) * | 1985-11-04 | 1987-04-21 | Dick Tomlinson | Weight vest |
US5144694A (en) * | 1991-03-09 | 1992-09-08 | Explore Incorporated | Exercise apparel and weight packets |
US6185744B1 (en) * | 1998-01-26 | 2001-02-13 | Mike Poholski | Thermal vest |
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US20110162125A1 (en) * | 2006-08-17 | 2011-07-07 | Ali Nilforushan | Temperature Altering Garment and Methods of Use Thereon |
US8449588B2 (en) * | 2006-09-25 | 2013-05-28 | Stephen T. Horn and Phyllis Horn Joint Tenure IP Common | Duration and comfort in cooling vest |
Also Published As
Publication number | Publication date |
---|---|
US8800311B2 (en) | 2014-08-12 |
US20120055187A1 (en) | 2012-03-08 |
US8950207B2 (en) | 2015-02-10 |
US20110239682A1 (en) | 2011-10-06 |
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