US20140069435A1 - Oral appliance with auto negative pressure control and method thereof - Google Patents
Oral appliance with auto negative pressure control and method thereof Download PDFInfo
- Publication number
- US20140069435A1 US20140069435A1 US14/079,687 US201314079687A US2014069435A1 US 20140069435 A1 US20140069435 A1 US 20140069435A1 US 201314079687 A US201314079687 A US 201314079687A US 2014069435 A1 US2014069435 A1 US 2014069435A1
- Authority
- US
- United States
- Prior art keywords
- negative pressure
- user
- physiological status
- oral appliance
- extraction unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A61M1/0031—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/71—Suction drainage systems
- A61M1/74—Suction control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02405—Determining heart rate variability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0806—Detecting, measuring or recording devices for evaluating the respiratory organs by whole-body plethysmography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0809—Detecting, measuring or recording devices for evaluating the respiratory organs by impedance pneumography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4809—Sleep detection, i.e. determining whether a subject is asleep or not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4818—Sleep apnoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B7/00—Instruments for auscultation
- A61B7/02—Stethoscopes
- A61B7/04—Electric stethoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/56—Devices for preventing snoring
-
- A61M1/0037—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/71—Suction drainage systems
- A61M1/74—Suction control
- A61M1/75—Intermittent or pulsating suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M16/0009—Accessories therefor, e.g. sensors, vibrators, negative pressure with sub-atmospheric pressure, e.g. during expiration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0051—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes with alarm devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0036—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the breathing tube and used in both inspiratory and expiratory phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0042—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the expiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
- A61M2230/06—Heartbeat rate only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/08—Other bio-electrical signals
- A61M2230/14—Electro-oculogram [EOG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/60—Muscle strain, i.e. measured on the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/65—Impedance, e.g. conductivity, capacity
Definitions
- the present application generally relates to an oral appliance with automatic negative pressure control based bio feedback.
- Obstructive sleep apnea (OSA), hypopnea, and upper airway resistance syndrome (UARS) are among a variety of known disorders characterized by episodes of complete or partial upper airway obstruction during such as sleep, anesthetization, or post anesthesia.
- OSA, hypopnea, and UARS cause intermittent interruption of ventilation during sleep with the consequence of potentially severe oxyhemoglobin desaturation.
- OSA, hypopnea, and UARS experience repeated, frequent arousal from sleep in response to the oxygen deprivation. The arousals result in sleep fragmentation and poor sleep continuity.
- a prior oral device for treatment of obstructive sleep disorders is already disclosed. It is characterized in that the tongue is protected and separated from the teeth when the device is in use.
- the oral device further comprises a tongue shaped cavity for receiving the tongue.
- a negative pressure is applied directly on the soft tissues of the tongue to hold the tongue within the cavity.
- such negative pressure may cause damage to the soft tissues of the tongue.
- a negative air pressure source expels the air from the oral cavity to pull the tongue and the palate forward so that the upper airway is unobstructed.
- Embodiments of an oral appliance for automatically control negative pressure supplied in an oral cavity and a method therefore are disclosed.
- the automatic negative pressure control is based on physiological signals feedback from the user.
- An exemplary embodiment provides an oral appliance with automatic negative pressure control, comprising: a sensing unit, for sensing a physiological signal from a user and outputting said sensed physiological signal; a physiological status extraction unit, coupled to said sensing unit, for extracting a physiological status based on said sensed physiological signal from said sensing unit; a negative pressure source, for providing a negative pressure; an oral interface, for connecting said negative pressure source and interfacing with oral cavity, and a negative pressure control unit, coupled to said physiological status extraction unit and said negative pressure source, for automatically controlling said negative pressure source based on said physiological status provided from said physiological status extraction unit.
- Another exemplary embodiment provides a method applied in an oral appliance, for automatic controlling negative pressure supplied to a user's oral cavity.
- the method comprises: sensing a physiological signal from the user and outputting the sensed physiological signal; extracting a physiological status based on said sensed physiological signal; and automatically controlling the negative pressure provided to the user's oral cavity based on said physiological status.
- Still yet another exemplary embodiment provides a method applied in an oral appliance, for automatic controlling a negative pressure supplied to a user's oral cavity, the method comprising: automatically controlling the negative pressure provided to the user's oral cavity based on the interval.
- FIG. 1 shows a block diagram for an oral appliance with negative pressure for enhancing upper airway stability, according to an exemplary embodiment.
- FIGS. 2A and 2B show an application diagram and a flow chart in an example #1 of the embodiment to control the negative pressure according to user body posture.
- FIGS. 3A and 3B show an application diagram and a flow chart in an example #2 of the embodiment to control the negative pressure according to whether a user is asleep or awake.
- FIGS. 4A and 4B show an application diagram and a flow chart in an example #3 of the embodiment to control the negative pressure according to whether a user is in REM (Rapid Eye Movement) period.
- FIGS. 5A and 5B show an application diagram and a flow chart in an example #4 of the embodiment to control the negative pressure according to whether a user is in muscle relaxation period.
- FIGS. 6A and 6B show an application diagram and a flow chart in an example #5 of the embodiment to control the negative pressure according to the detection of snore sound.
- FIGS. 7A and 7B show an application diagram and a flow chart in an example #6 of the embodiment to control the negative pressure according to airway pressure oscillation caused by snoring.
- FIGS. 8A and 8B show an application diagram and a flow chart in an example #7 of the embodiment to control the negative pressure according to O 2 desaturation detection.
- FIGS. 9A and 9B show an application diagram and a flow chart in an example #8 of the embodiment to control the negative pressure according to CO 2 concentration in airway.
- FIG. 10A ⁇ 10C and FIG. 10D show application diagrams and a flow chart in an example #9 of the embodiment to control the negative pressure according to abnormal breathing detection.
- FIG. 11A ⁇ 11B and FIG. 11C show application diagrams and a flow chart in an example #10 of the embodiment to control the negative pressure according to HRV detection.
- FIG. 12A and FIG. 12B show an application diagram and a flow chart in an example #11 of the embodiment to control the negative pressure according to oral suction intent detection.
- FIG. 13A and FIG. 13B show an application diagram and a flow chart in an example #12 of the embodiment to control the negative pressure according to open mouth detection.
- FIG. 14 shows a block diagram for an oral appliance with negative pressure for enhancing upper airway stability, in an example #13 of the exemplary embodiment to provide the time interval control.
- FIG. 1 shows a block diagram for an oral appliance with negative pressure for enhancing upper airway stability, according to an exemplary embodiment.
- the oral appliance 100 at least includes a main body 110 , a sensing unit 150 and an oral interface 160 .
- the main body 110 includes a physiological status extraction unit 120 , a negative pressure control unit 130 and a negative pressure source 140 .
- the sensing unit 150 senses physiological signals feedback from a user and outputs the sensed physiological signals to the physiological status extraction unit 120 .
- the sensing unit 150 includes at least one of the following sensors: position sensor, accelerator, gravity sensor, tilt sensor, motion sensor, electrodes, microphone, piezo-transducer, pressure sensor, oximeter, CO 2 sensor, thermistor, hotwire, flow sensor, respiratory inductive plethysmograph (RIP), strain gauge, impedance pneumograph, etc.
- the physiological status extraction unit 120 extracts physiological status based on the signals from the sensing unit 150 .
- the physiological status includes for example, body posture, sleep/wake status, Rapid Eye Movement (REM) period, muscle relaxation period, snore, oxygen (O 2 ) desaturation, CO 2 concentration in airway, breath event, heart rate variability, oral suction intent, open mouth intent etc.
- REM Rapid Eye Movement
- O 2 oxygen
- the negative pressure control unit 130 controls the operation of the negative pressure source 140 based on the physiological status provided from the physiological status extraction unit 120 .
- the control of the negative pressure control unit for example includes auto pressure on, auto pressure off, pressure increase, pressure decrease, intermittent, on-demand, auto relaxation, auto titration, auto pressure adjustment etc. Intermittent refers to that the negative pressure is turned on and turned off periodically, instead of being continuously on.
- On-demand control refers to that the negative pressure is activated when a patient is having or prone to have a sleep-breathing disorder event, instead of being continuously supplied.
- Auto relaxation refers to that the negative pressure is automatically decreased to a lower value for certain period of time, instead of being continuously at the fixed higher value of pressure setting.
- Auto titration control refers to that the oral appliance 100 will provide different negative pressure settings to a patient's oral cavity during a titrating period of time; and the optimized pressure setting with the least breathing disorder events corresponding to a patient's patterns of a plurality of breaths is automatically determined for the treatment of a patient's obstructive sleep apnea during the sleep.
- the negative pressure source 140 supplies negative pressure in oral cavity.
- the negative pressure source 140 is controlled by the negative pressure control unit 130 .
- the negative pressure supplied in oral cavity is for preventing airway occlusion during sleep, minimizing sleep apnea and snoring, by pulling the tongue and soft palate away from the posterior laryngeal wall, opening the airway through the nasal passage to facilitate natural breathing.
- the oral interface 160 is for connecting the negative pressure supplied by the negative pressure source 140 when inserting in or interfacing with oral cavity.
- the oral appliance according to the embodiment of the invention has several usage examples.
- the operating flows of different embodiments may be performed periodically,
- FIGS. 2A and 2B show an application diagram and a flow chart in an example #1 of the embodiment to control the negative pressure according to user body posture.
- the sensing unit 150 may include at least one of a position sensor, an accelerator, a gravity sensor and a tilt sensor, etc.
- the physiological status extraction unit 120 determines the body posture being upright posture, supine posture or prone/side posture.
- the negative pressure control unit 130 turns off the negative pressure source 140 (step 220 ).
- the negative pressure control unit 130 automatically controls the negative pressure (step 240 ), for example to increase the negative pressure to a higher value. If the negative pressure source 140 was turned off, then in step 240 , the negative pressure control unit 130 automatically turns on the negative pressure source 140 .
- the negative pressure control unit 130 automatically controls the negative pressure, for example to decrease the negative pressure to a lower value. If the negative pressure source 140 was turned off, then in step 260 , the negative pressure control unit 130 automatically turns on the negative pressure source 140 . Further, in steps 240 or 260 , the negative pressure is increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on body posture.
- body posture which means user does not lie down and OSA, hypopnea or UARS is less likely to occur
- the negative pressure source 140 is turned off, to reduce the power consumption of the oral appliance 100 .
- the body posture is supine, prone or side posture, which means the user may lie down and OSA, hypopnea or MARS is more likely to occur
- the negative pressure source 140 is on and controlled to generate negative pressure in user's oral cavity and to improve the patency of user's upper airway.
- FIGS. 3A and 3B show an application diagram and a flow chart in an example #2 of the embodiment to control the negative pressure according to whether user is asleep or awake.
- the sensing unit 150 may include at least one of an accelerator, a motion sensor or electrodes. If the sensing unit 150 is an accelerator or a motion sensor, the sensing unit 150 senses movement statuses of a user to determine whether the user is asleep or awake with less precise sleep-wakes staging. On the other hand, if the sensing unit 150 is electroencephalogram (EEG) electrodes, the sensing unit 150 senses brain waves (for example, c waves) of user to determine whether user is asleep or awake with more precise sleep-wakes staging.
- EEG electroencephalogram
- the physiological status extraction unit 120 determines the user is asleep or awake, Now please refer to FIG. 3B , if user is awake (step 310 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 320 ), for example, to turn off the negative pressure source 140 . If user is asleep (step 310 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 330 ), for example, to turn on the negative pressure source 140 .
- the supplied negative pressure is adjusted based on whether user is asleep or awake. When user is awake, then the negative pressure source 140 is turned off, for reducing power consumption of the oral appliance 100 . If user is asleep, then the negative pressure source 140 is powered on for providing negative pressure in oral cavity to improve the patency of user upper airway.
- FIGS. 4A and 4B show an application diagram and a flow chart in an example #3 of the embodiment to control the negative pressure according to whether user is in REM (Rapid Eye Movement) period.
- the sensing unit 150 may be Electrooculography (EOG) electrodes or Electromyography (EMG) electrodes, for sensing whether a user is in REM period.
- EOG Electrooculography
- EMG Electromyography
- Snore, JARS or OSA is mostly occurred during REM period; and therefore, in example #3, if a user is detected to be in REM period, then the negative pressure is automatically controlled.
- the physiological status extraction unit 120 determines whether a user is in REM period.
- the negative pressure control unit 130 automatically controls the negative pressure (step 420 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure by predefined values.
- the negative pressure control unit 130 automatically controls the negative pressure (step 430 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or eventually turn off the negative pressure. Further, in step 430 , the negative pressure may be decreased by predetermined values.
- the supplied negative pressure is adjusted based on whether a user is in REM period. If a user is not in REM period, which means Snore, UARS or OSA may not occur, then the negative pressure is decreased or turned off, for reducing power consumption of the oral appliance 100 . If a user is in REM period, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 5A and 5B show an application diagram and a flow chart in an example #4 of the embodiment to control the negative pressure according to whether a user s in muscle relaxation period.
- the sensing unit 150 may be Electrooculography (EOG) electrodes or Electromyography (EMG) electrodes, for sensing whether a user is in muscle relaxation period.
- EOG Electrooculography
- EMG Electromyography
- Snore, UARS or OSA tends to occur during muscle relaxation period; and therefore, in example #4, if a user is detected to be in muscle relaxation period, then the negative pressure is automatically controlled.
- the physiological status extraction unit 120 determines whether a user is in muscle relaxation period.
- the negative pressure control unit 130 automatically controls the negative pressure (step 520 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure.
- the negative pressure control unit 130 automatically controls the negative pressure (step 530 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or eventually turn off the negative pressure.
- the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on whether a user is in muscle relaxation period. If a user is not in muscle relaxation period, which means snore, UARS or OSA may not occur, then the negative pressure is decreased, for reducing power consumption of the oral appliance 100 . If a user is in muscle relaxation period, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 6A and 6B show an application diagram and a flow chart in an example #5 of the embodiment to control the negative pressure according to the detection of snore sound.
- the sensing unit 150 may be a microphone or a piezo transducer, for sensing snore sound.
- UARS or OSA tends to occur when a user is snoring; and therefore, in example #5, if snore sound is detected, then the negative pressure is automatically controlled.
- the physiological status extraction unit 120 determines the existence of snore sound.
- the negative pressure control unit 130 automatically controls the negative pressure (step 620 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure.
- the negative pressure control unit 130 automatically controls the negative pressure (step 630 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure.
- the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on the detection of snore sound. If snore sound is not detected, which means UARS or OSA may not occur, then the negative pressure is turned off or decreased, for reducing power consumption. If snore sound is detected, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 7A and 7B show an application diagram and a flow chart in an example #6 of the embodiment to control the negative pressure according to airway pressure oscillation (at higher frequencies than normal breathing) due to snore.
- the sensing unit 150 may be a pressure sensor or a cannula connected to a pressure sensor, for sensing airway pressure and its oscillation.
- Snore can be identified by airway pressure oscillation. If snore is identified, which means UARS or OSA tends to occur, and therefore, in example #6, if airway pressure is oscillated, then the negative pressure is automatically controlled.
- the physiological status extraction unit 120 determines the oscillation of airway pressure.
- the negative pressure control unit 130 automatically controls the negative pressure (step 720 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure.
- the negative pressure control unit 130 automatically controls the negative pressure (step 730 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure.
- the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on the oscillation of airway pressure. If airway pressure is not oscillated, which means Snore is not present, then the negative pressure is turned off or decreased, for reducing power consumption. If airway pressure is oscillated, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 8A and 8B show an application diagram and a flow chart in an example #7 of the embodiment to control the negative pressure according to O 2 desaturation detection.
- the sensing unit 150 may include an oximeter, for sensing O 2 concentration in blood vessels.
- UARS or OSA causes decrease of O 2 concentration in blood vessels; and therefore, in example #7, if O 2 concentration in blood vessels is decreased, then the negative pressure is automatically controlled.
- the physiological status extraction unit 120 determines the O 2 concentration in blood vessels.
- the negative pressure control unit 130 automatically controls the negative pressure (step 820 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure.
- the negative pressure control unit 130 automatically controls the negative pressure (step 830 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure.
- the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on whether O 2 concentration in blood vessels is decreased. If O 2 concentration in blood vessels is not decreased, which means UARS or OSA may not occur, then the negative pressure is decreased or turned off, for reducing power consumption. If O 2 concentration in blood vessels is decreased, which means UARS or OSA may occur, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 9A and 9B show an application diagram and a flow chart in an example #8 of the embodiment to control the negative pressure according to CO 2 concentration in airway.
- the sensing unit 150 may include a CO 2 sensor, for sensing CO 2 concentration in airway.
- UARS or OSA causes low or absent end-tidal CO 2 concentration; and therefore, in example #8, if end-tidal CO 2 concentration in airway is decreased or absent, then the negative pressure is automatically controlled.
- the physiological status extraction unit 120 determines the end-tidal CO 2 concentration in airway.
- the negative pressure control unit 130 automatically controls the negative pressure (step 820 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure.
- the negative pressure control unit 130 automatically controls the negative pressure (step 930 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure.
- the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on whether end-tidal CO 2 concentration in airway is decreased or absent. If CO 2 concentration in airway is kept, which means UARS or OSA may not occur, then the negative pressure is decreased or turned off, for reducing power consumption. If CO 2 concentration in airway is decreased, which means Snore, UARS or OSA may occur, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 10A-10C and FIG. 10D show application diagrams and a flow chart in an example #9 of the embodiment to control the negative pressure according to abnormal breathing detection.
- the sensing unit 150 may he a pressure sensor or a cannula connected to a pressure sensor for sensing pressure variation in airway, as shown in FIG. 10A .
- the sensing unit 150 may he a respiratory inductive plethysmograph, a strain gauge or an impedance pneumograph for sensing abdominal breathing and/or thoracic breathing, as shown in FIG. 10B .
- the sensing unit 150 may be a thermistor air flow sensor or a hotwire sensor for sensing flow variation in airway, as shown in FIG. 10C .
- the physiological status extraction unit 120 determines whether abnormal breathing event is presented. Snore, UARS or OSA causes abnormal breathing events. Therefore, in example #9, if an abnormal breathing event is detected, then the negative pressure is automatically controlled.
- step 1010 if an abnormal breathing event is detected (step 1010 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 1020 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure. If an abnormal breathing event does not occur (step 1010 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 1030 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or turned off the negative pressure. Further, in step 1020 or 1030 , the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on whether breath is abnormal. If not, which means snore, UARS or OSA may not occur, then the negative pressure is turned off or decreased, for reducing power consumption. If yes, which means snore, UARS or OSA may occur, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- automatic negative pressure control may be performed based on breath phase.
- the physiological status extraction unit 120 determines breath phase (exhalation or inhalation).
- breath phase exhalation or inhalation
- the negative pressure is automatically decreased by the negative pressure control unit 130 .
- inhalation phase the negative pressure is automatically increased by the negative pressure control unit 130 .
- the negative pressure control unit 130 provides different negative pressure to a patient's oral cavity during a titrating period of time; and the said physiological status extraction unit 120 determines an optimized pressure setting with least breathing disorder events corresponding to a patient's breaths patterns.
- FIGS. 11A-11B and FIG. 11C show application diagrams and a flow chart in an example #10 of the embodiment to control the negative pressure according to HRV detection.
- the sensing unit 150 may he Electro-Cardiogram (ECG) electrodes for sensing electrical activity of the heart.
- ECG Electro-Cardiogram
- the sensing unit 150 may include a photoplethysmography (PPG) for sensing cardiac cycles.
- PPG photoplethysmography
- the physiological status extraction unit 120 determines HRV or whether heart rate is abnormal or stopped.
- UARS or OSA is associated with high heart rate variability, wherein heart rate variability may he resulted from apnea. Therefore, in example #10, if high HRV is detected, then the negative pressure is automatically controlled.
- step 1110 it is determined whether heart rate is abnormal or stopped (step 1120 ). If heart rate is abnormal or stopped, then a warning signal is generated and the negative pressure source 140 is automatically turned off by the negative pressure control unit 130 . If HRV is detected and heart rate is not stopped, then the negative pressure control unit 130 automatically controls the negative pressure (step 1140 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure. If high HRV does not occur (step 1110 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 1150 ), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure. Further, in step 1140 or 1150 , the negative pressure may be increased or decreased by predetermined values.
- the supplied negative pressure is adjusted based on whether HRV is over a threshold. If not, which means UARS or OSA may not occur, then the negative pressure is turned off or decreased, for reducing power consumption. If yes, which means UARS or OSA may occur, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 12A and FIG. 12B show an application diagram and a flow chart in an example #11 of the embodiment to control the negative pressure according to oral suction intent detection.
- the sensing unit 150 may be a pressure sensor or a cannula connected to a pressure sensor for sensing pressure in an oral cavity.
- the physiological status extraction unit 120 determines oral suction intent. Further, if the pressure in oral cavity is decreased, then the physiological status extraction unit 120 determines intent in oral suction, which represents user's intent to provide negative pressure to the oral cavity. Therefore, in example #11, if oral suction intent is detected, then the negative pressure is automatically controlled.
- the negative pressure control unit 130 automatically controls the negative pressure (step 1220 ), for example to turn on the negative pressure source 140 or automatically increase the negative pressure. If no oral suction intent is detected (step 1210 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 1230 ), for example to automatically turn off the negative pressure source 140 or maintain the negative pressure. Further, in step 1220 , the negative pressure may be increased by predetermined values.
- the negative pressure is adjusted based on oral suction intent. If no oral suction intent, which means a user has no intention to provide negative pressure to the oral cavity then the negative pressure is not turned on, for reducing power consumption. If oral suction intent is detected, which means a user has an intention to provide negative pressure to the oral cavity, then the negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway.
- FIGS. 13A and 13B show an application diagram and a flow chart in an example #12 of the embodiment to control the negative pressure according to open mouth intent detection.
- the sensing unit 150 may be electromyography electrodes for sensing electrical activity of muscles near mouth or jaw. Based on the sensing result of the sensing unit 150 , the physiological status extraction unit 120 determines open mouth intent. Further, if open mouth intent is detected, which means a user have an intention to open mouth, providing negative pressure to the oral cavity is stopped. Therefore, in example #12, if open mouth intent is detected, then the negative pressure is automatically controlled.
- step 1310 if open mouth intent is detected (step 1310 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 1320 ), for example to turn off the negative pressure source 140 . If open mouth intent does not occur (step 1310 ), then the negative pressure control unit 130 automatically controls the negative pressure (step 1330 ), for example to maintain the negative pressure.
- the negative pressure is adjusted based on open mouth intent. If a user has an intention to open mouth, then the negative pressure is turned off, for reducing power consumption. If no open mouth intent is detected, then the negative pressure is maintained, for providing negative pressure in oral cavity to improve the patency of upper airway.
- the flow chart is performed periodically. Further, anyone of the examples would be modified and combined with other example. For example, but not limited, the example #2 would be modified and combined with the example #1, so that, if the a user is detected as being in asleep, then the body posture of a user asleep would be detected as those in the example 1, for further controlling the negative pressure.
- Example #13 of the application provides an oral appliance with automatic negative pressure control and a method therefore.
- FIG. 14 shows a block diagram for the oral appliance with negative pressure for enhancing upper airway stability, in the example #13 of the exemplary embodiment to provide the time interval control
- the oral appliance with automatic negative pressure control includes: a negative pressure source 140 , for providing a negative pressure; an oral interface 160 , for connecting said negative pressure source and interfacing with an oral cavity, and a negative pressure control unit 130 for controlling said negative pressure source based on a time interval control 135 , such as auto on, auto pressure increase, intermittent, and auto relaxation.
- the negative pressure source 140 , the negative pressure control unit 130 and the time interval control 135 are inside the main body 110 .
- the negative pressure control unit 130 automatically turns the negative pressure on at a predetermined time interval after power on, under control of the time interval control.
- the negative pressure control unit 130 gradually increases the negative pressure to a predetermined value at a predetermined time interval after power on, under control of the time interval control.
- the negative pressure control unit 130 intermittently turns the negative pressure off and on at predetermined time periods, under control of the time interval control.
- the negative pressure control unit 130 periodically decreases the negative pressure to a low value for a predetermined time interval and then resuming to a high value, under control of the time interval control.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Pulmonology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Acoustics & Sound (AREA)
- Otolaryngology (AREA)
- Nursing (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Optics & Photonics (AREA)
- Obesity (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
- The application is a divisional application of U.S. patent application Ser. No. 12/561,364 filed on Sep. 17, 2009, which claims the benefit of U.S. Provisional Application Ser. No. 61/109,239, filed on Oct. 29, 2008, the subject matters of these applications are incorporated herein by reference.
- The present application generally relates to an oral appliance with automatic negative pressure control based bio feedback.
- Obstructive sleep apnea (OSA), hypopnea, and upper airway resistance syndrome (UARS) are among a variety of known disorders characterized by episodes of complete or partial upper airway obstruction during such as sleep, anesthetization, or post anesthesia. OSA, hypopnea, and UARS cause intermittent interruption of ventilation during sleep with the consequence of potentially severe oxyhemoglobin desaturation. Typically, those afflicted with OSA, hypopnea, and UARS experience repeated, frequent arousal from sleep in response to the oxygen deprivation. The arousals result in sleep fragmentation and poor sleep continuity.
- A prior oral device for treatment of obstructive sleep disorders is already disclosed. It is characterized in that the tongue is protected and separated from the teeth when the device is in use. The oral device further comprises a tongue shaped cavity for receiving the tongue. Moreover, a negative pressure is applied directly on the soft tissues of the tongue to hold the tongue within the cavity. However, such negative pressure may cause damage to the soft tissues of the tongue.
- Moreover, another prior oral appliance with a negative air supply for reducing sleep apnea and snoring is provided, in which a negative air pressure source expels the air from the oral cavity to pull the tongue and the palate forward so that the upper airway is unobstructed.
- Although various devices have been developed to facilitate breathing for those suffering from OSA, hypopnea or UARS by using oral negative pressure, they fail to properly control negative pressure applied to oral cavity.
- Embodiments of an oral appliance for automatically control negative pressure supplied in an oral cavity and a method therefore are disclosed. The automatic negative pressure control is based on physiological signals feedback from the user.
- An exemplary embodiment provides an oral appliance with automatic negative pressure control, comprising: a sensing unit, for sensing a physiological signal from a user and outputting said sensed physiological signal; a physiological status extraction unit, coupled to said sensing unit, for extracting a physiological status based on said sensed physiological signal from said sensing unit; a negative pressure source, for providing a negative pressure; an oral interface, for connecting said negative pressure source and interfacing with oral cavity, and a negative pressure control unit, coupled to said physiological status extraction unit and said negative pressure source, for automatically controlling said negative pressure source based on said physiological status provided from said physiological status extraction unit.
- Another exemplary embodiment provides a method applied in an oral appliance, for automatic controlling negative pressure supplied to a user's oral cavity. The method comprises: sensing a physiological signal from the user and outputting the sensed physiological signal; extracting a physiological status based on said sensed physiological signal; and automatically controlling the negative pressure provided to the user's oral cavity based on said physiological status.
- Still yet another exemplary embodiment provides a method applied in an oral appliance, for automatic controlling a negative pressure supplied to a user's oral cavity, the method comprising: automatically controlling the negative pressure provided to the user's oral cavity based on the interval.
- It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosed embodiments, as claimed.
-
FIG. 1 shows a block diagram for an oral appliance with negative pressure for enhancing upper airway stability, according to an exemplary embodiment. -
FIGS. 2A and 2B show an application diagram and a flow chart in an example #1 of the embodiment to control the negative pressure according to user body posture. -
FIGS. 3A and 3B show an application diagram and a flow chart in an example #2 of the embodiment to control the negative pressure according to whether a user is asleep or awake. -
FIGS. 4A and 4B show an application diagram and a flow chart in an example #3 of the embodiment to control the negative pressure according to whether a user is in REM (Rapid Eye Movement) period. -
FIGS. 5A and 5B show an application diagram and a flow chart in an example #4 of the embodiment to control the negative pressure according to whether a user is in muscle relaxation period. -
FIGS. 6A and 6B show an application diagram and a flow chart in an example #5 of the embodiment to control the negative pressure according to the detection of snore sound. -
FIGS. 7A and 7B show an application diagram and a flow chart in an example #6 of the embodiment to control the negative pressure according to airway pressure oscillation caused by snoring. -
FIGS. 8A and 8B show an application diagram and a flow chart in an example #7 of the embodiment to control the negative pressure according to O2 desaturation detection. -
FIGS. 9A and 9B show an application diagram and a flow chart in an example #8 of the embodiment to control the negative pressure according to CO2 concentration in airway. -
FIG. 10A˜10C andFIG. 10D show application diagrams and a flow chart in an example #9 of the embodiment to control the negative pressure according to abnormal breathing detection. -
FIG. 11A˜11B andFIG. 11C show application diagrams and a flow chart in an example #10 of the embodiment to control the negative pressure according to HRV detection. -
FIG. 12A andFIG. 12B show an application diagram and a flow chart in an example #11 of the embodiment to control the negative pressure according to oral suction intent detection. -
FIG. 13A andFIG. 13B show an application diagram and a flow chart in an example #12 of the embodiment to control the negative pressure according to open mouth detection. -
FIG. 14 shows a block diagram for an oral appliance with negative pressure for enhancing upper airway stability, in an example #13 of the exemplary embodiment to provide the time interval control. - Reference will now be made in detail to the present exemplary embodiments, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers are used in the drawings and the description to refer to the same or like parts.
-
FIG. 1 shows a block diagram for an oral appliance with negative pressure for enhancing upper airway stability, according to an exemplary embodiment. As shown inFIG. 1 , theoral appliance 100 at least includes amain body 110, asensing unit 150 and anoral interface 160. Themain body 110 includes a physiologicalstatus extraction unit 120, a negativepressure control unit 130 and anegative pressure source 140. - The
sensing unit 150 senses physiological signals feedback from a user and outputs the sensed physiological signals to the physiologicalstatus extraction unit 120. Thesensing unit 150 includes at least one of the following sensors: position sensor, accelerator, gravity sensor, tilt sensor, motion sensor, electrodes, microphone, piezo-transducer, pressure sensor, oximeter, CO2 sensor, thermistor, hotwire, flow sensor, respiratory inductive plethysmograph (RIP), strain gauge, impedance pneumograph, etc. - The physiological
status extraction unit 120 extracts physiological status based on the signals from thesensing unit 150. The physiological status includes for example, body posture, sleep/wake status, Rapid Eye Movement (REM) period, muscle relaxation period, snore, oxygen (O2) desaturation, CO2 concentration in airway, breath event, heart rate variability, oral suction intent, open mouth intent etc. - The negative
pressure control unit 130 controls the operation of thenegative pressure source 140 based on the physiological status provided from the physiologicalstatus extraction unit 120. The control of the negative pressure control unit for example includes auto pressure on, auto pressure off, pressure increase, pressure decrease, intermittent, on-demand, auto relaxation, auto titration, auto pressure adjustment etc. Intermittent refers to that the negative pressure is turned on and turned off periodically, instead of being continuously on. On-demand control refers to that the negative pressure is activated when a patient is having or prone to have a sleep-breathing disorder event, instead of being continuously supplied. Auto relaxation refers to that the negative pressure is automatically decreased to a lower value for certain period of time, instead of being continuously at the fixed higher value of pressure setting. Auto titration control refers to that theoral appliance 100 will provide different negative pressure settings to a patient's oral cavity during a titrating period of time; and the optimized pressure setting with the least breathing disorder events corresponding to a patient's patterns of a plurality of breaths is automatically determined for the treatment of a patient's obstructive sleep apnea during the sleep. - The
negative pressure source 140 supplies negative pressure in oral cavity. Thenegative pressure source 140 is controlled by the negativepressure control unit 130. The negative pressure supplied in oral cavity is for preventing airway occlusion during sleep, minimizing sleep apnea and snoring, by pulling the tongue and soft palate away from the posterior laryngeal wall, opening the airway through the nasal passage to facilitate natural breathing. - The
oral interface 160 is for connecting the negative pressure supplied by thenegative pressure source 140 when inserting in or interfacing with oral cavity. - The oral appliance according to the embodiment of the invention has several usage examples. In the following examples, the operating flows of different embodiments may be performed periodically,
-
FIGS. 2A and 2B show an application diagram and a flow chart in an example #1 of the embodiment to control the negative pressure according to user body posture. In example #1, thesensing unit 150 may include at least one of a position sensor, an accelerator, a gravity sensor and a tilt sensor, etc. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines the body posture being upright posture, supine posture or prone/side posture. Now please refer toFIG. 2B , If the body posture is detected as upright posture (step 210), then the negativepressure control unit 130 turns off the negative pressure source 140 (step 220). If the body posture is detected as supine posture (step 230), which means patient is more likely to have OSA, hypopnea or UARS, then the negativepressure control unit 130 automatically controls the negative pressure (step 240), for example to increase the negative pressure to a higher value. If thenegative pressure source 140 was turned off, then instep 240, the negativepressure control unit 130 automatically turns on thenegative pressure source 140. If the body posture is detected as prone or side posture (step 250), which means OSA, hypopnea or UARS would be less likely occurred, then the negativepressure control unit 130 automatically controls the negative pressure, for example to decrease the negative pressure to a lower value. If thenegative pressure source 140 was turned off, then instep 260, the negativepressure control unit 130 automatically turns on thenegative pressure source 140. Further, insteps - In example #1, the supplied negative pressure is adjusted based on body posture. When the body posture is upright posture, which means user does not lie down and OSA, hypopnea or UARS is less likely to occur, then the
negative pressure source 140 is turned off, to reduce the power consumption of theoral appliance 100. If the body posture is supine, prone or side posture, which means the user may lie down and OSA, hypopnea or MARS is more likely to occur, then thenegative pressure source 140 is on and controlled to generate negative pressure in user's oral cavity and to improve the patency of user's upper airway. -
FIGS. 3A and 3B show an application diagram and a flow chart in an example #2 of the embodiment to control the negative pressure according to whether user is asleep or awake. In example #2, thesensing unit 150 may include at least one of an accelerator, a motion sensor or electrodes. If thesensing unit 150 is an accelerator or a motion sensor, thesensing unit 150 senses movement statuses of a user to determine whether the user is asleep or awake with less precise sleep-wakes staging. On the other hand, if thesensing unit 150 is electroencephalogram (EEG) electrodes, thesensing unit 150 senses brain waves (for example, c waves) of user to determine whether user is asleep or awake with more precise sleep-wakes staging. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines the user is asleep or awake, Now please refer toFIG. 3B , if user is awake (step 310), then the negativepressure control unit 130 automatically controls the negative pressure (step 320), for example, to turn off thenegative pressure source 140. If user is asleep (step 310), then the negativepressure control unit 130 automatically controls the negative pressure (step 330), for example, to turn on thenegative pressure source 140. - In example #2 the supplied negative pressure is adjusted based on whether user is asleep or awake. When user is awake, then the
negative pressure source 140 is turned off, for reducing power consumption of theoral appliance 100. If user is asleep, then thenegative pressure source 140 is powered on for providing negative pressure in oral cavity to improve the patency of user upper airway. -
FIGS. 4A and 4B show an application diagram and a flow chart in an example #3 of the embodiment to control the negative pressure according to whether user is in REM (Rapid Eye Movement) period. In example #3, thesensing unit 150 may be Electrooculography (EOG) electrodes or Electromyography (EMG) electrodes, for sensing whether a user is in REM period. Snore, JARS or OSA is mostly occurred during REM period; and therefore, in example #3, if a user is detected to be in REM period, then the negative pressure is automatically controlled. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines whether a user is in REM period. Now please refer toFIG. 4B , if a user is in REM period (step 410), then the negativepressure control unit 130 automatically controls the negative pressure (step 420), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure by predefined values. If a user is not in REM period (step 410), then the negativepressure control unit 130 automatically controls the negative pressure (step 430), for example to maintain the negative pressure, automatically decrease the negative pressure, or eventually turn off the negative pressure. Further, instep 430, the negative pressure may be decreased by predetermined values. - In example #3 the supplied negative pressure is adjusted based on whether a user is in REM period. If a user is not in REM period, which means Snore, UARS or OSA may not occur, then the negative pressure is decreased or turned off, for reducing power consumption of the
oral appliance 100. If a user is in REM period, then thenegative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 5A and 5B show an application diagram and a flow chart in an example #4 of the embodiment to control the negative pressure according to whether a user s in muscle relaxation period. In example #4, thesensing unit 150 may be Electrooculography (EOG) electrodes or Electromyography (EMG) electrodes, for sensing whether a user is in muscle relaxation period. Snore, UARS or OSA tends to occur during muscle relaxation period; and therefore, in example #4, if a user is detected to be in muscle relaxation period, then the negative pressure is automatically controlled. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines whether a user is in muscle relaxation period. Now please refer toFIG. 5B , if a user is in muscle relaxation period (step 510), then the negativepressure control unit 130 automatically controls the negative pressure (step 520), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If a user is not in muscle relaxation period (step 510), then the negativepressure control unit 130 automatically controls the negative pressure (step 530), for example to maintain the negative pressure, automatically decrease the negative pressure, or eventually turn off the negative pressure. Further, instep - In example #4 the supplied negative pressure is adjusted based on whether a user is in muscle relaxation period. If a user is not in muscle relaxation period, which means snore, UARS or OSA may not occur, then the negative pressure is decreased, for reducing power consumption of the
oral appliance 100. If a user is in muscle relaxation period, then thenegative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 6A and 6B show an application diagram and a flow chart in an example #5 of the embodiment to control the negative pressure according to the detection of snore sound. In example #5, thesensing unit 150 may be a microphone or a piezo transducer, for sensing snore sound. UARS or OSA tends to occur when a user is snoring; and therefore, in example #5, if snore sound is detected, then the negative pressure is automatically controlled. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines the existence of snore sound. Now please refer toFIG. 6B , if snore sound is detected (step 610), then the negativepressure control unit 130 automatically controls the negative pressure (step 620), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If snore sound is not detected (step 610), then the negativepressure control unit 130 automatically controls the negative pressure (step 630), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure. Further, instep 620 or 630, the negative pressure may be increased or decreased by predetermined values. - In example #5, the supplied negative pressure is adjusted based on the detection of snore sound. If snore sound is not detected, which means UARS or OSA may not occur, then the negative pressure is turned off or decreased, for reducing power consumption. If snore sound is detected, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 7A and 7B show an application diagram and a flow chart in an example #6 of the embodiment to control the negative pressure according to airway pressure oscillation (at higher frequencies than normal breathing) due to snore. In example #6, thesensing unit 150 may be a pressure sensor or a cannula connected to a pressure sensor, for sensing airway pressure and its oscillation. Snore can be identified by airway pressure oscillation. If snore is identified, which means UARS or OSA tends to occur, and therefore, in example #6, if airway pressure is oscillated, then the negative pressure is automatically controlled. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines the oscillation of airway pressure. Now please refer toFIG. 7B , if airway pressure is oscillated (step 710), then the negativepressure control unit 130 automatically controls the negative pressure (step 720), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If airway pressure is not oscillated (step 710), then the negativepressure control unit 130 automatically controls the negative pressure (step 730), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure. Further, instep - In example #6, the supplied negative pressure is adjusted based on the oscillation of airway pressure. If airway pressure is not oscillated, which means Snore is not present, then the negative pressure is turned off or decreased, for reducing power consumption. If airway pressure is oscillated, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 8A and 8B show an application diagram and a flow chart in an example #7 of the embodiment to control the negative pressure according to O2 desaturation detection. In example #7, thesensing unit 150 may include an oximeter, for sensing O2 concentration in blood vessels. UARS or OSA causes decrease of O2 concentration in blood vessels; and therefore, in example #7, if O2 concentration in blood vessels is decreased, then the negative pressure is automatically controlled. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines the O2 concentration in blood vessels. Now please refer toFIG. 8B , if O2 concentration in blood vessels is decreased (step 810), then the negativepressure control unit 130 automatically controls the negative pressure (step 820), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If O2 concentration in blood vessels is kept (step 810), then the negativepressure control unit 130 automatically controls the negative pressure (step 830), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure. Further, instep - In example #7, the supplied negative pressure is adjusted based on whether O2 concentration in blood vessels is decreased. If O2 concentration in blood vessels is not decreased, which means UARS or OSA may not occur, then the negative pressure is decreased or turned off, for reducing power consumption. If O2 concentration in blood vessels is decreased, which means UARS or OSA may occur, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 9A and 9B show an application diagram and a flow chart in an example #8 of the embodiment to control the negative pressure according to CO2 concentration in airway. In example #8, thesensing unit 150 may include a CO2 sensor, for sensing CO2 concentration in airway. UARS or OSA causes low or absent end-tidal CO2 concentration; and therefore, in example #8, if end-tidal CO2 concentration in airway is decreased or absent, then the negative pressure is automatically controlled. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines the end-tidal CO2 concentration in airway. Now please refer toFIG. 9B , if end-tidal CO2 concentration in airway is decreased or absent (step 910), then the negativepressure control unit 130 automatically controls the negative pressure (step 820), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If end-tidal CO2 concentration in airway is kept or not decreased (step 910), then the negativepressure control unit 130 automatically controls the negative pressure (step 930), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure. Further, instep - In example #8, the supplied negative pressure is adjusted based on whether end-tidal CO2 concentration in airway is decreased or absent. If CO2 concentration in airway is kept, which means UARS or OSA may not occur, then the negative pressure is decreased or turned off, for reducing power consumption. If CO2 concentration in airway is decreased, which means Snore, UARS or OSA may occur, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 10A-10C andFIG. 10D show application diagrams and a flow chart in an example #9 of the embodiment to control the negative pressure according to abnormal breathing detection. Thesensing unit 150 may he a pressure sensor or a cannula connected to a pressure sensor for sensing pressure variation in airway, as shown inFIG. 10A . Thesensing unit 150 may he a respiratory inductive plethysmograph, a strain gauge or an impedance pneumograph for sensing abdominal breathing and/or thoracic breathing, as shown inFIG. 10B . Thesensing unit 150 may be a thermistor air flow sensor or a hotwire sensor for sensing flow variation in airway, as shown inFIG. 10C . - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines whether abnormal breathing event is presented. Snore, UARS or OSA causes abnormal breathing events. Therefore, in example #9, if an abnormal breathing event is detected, then the negative pressure is automatically controlled. - Now please refer to
FIG. 10D , if an abnormal breathing event is detected (step 1010), then the negativepressure control unit 130 automatically controls the negative pressure (step 1020), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If an abnormal breathing event does not occur (step 1010), then the negativepressure control unit 130 automatically controls the negative pressure (step 1030), for example to maintain the negative pressure, automatically decrease the negative pressure, or turned off the negative pressure. Further, instep - In example #9, the supplied negative pressure is adjusted based on whether breath is abnormal. If not, which means snore, UARS or OSA may not occur, then the negative pressure is turned off or decreased, for reducing power consumption. If yes, which means snore, UARS or OSA may occur, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. - Still further, in the example #9, automatic negative pressure control may be performed based on breath phase. Based on the sensing result of the
sensing unit 150 inFIG. 10A , 10B or 10C, the physiologicalstatus extraction unit 120 determines breath phase (exhalation or inhalation). In exhalation phase, the negative pressure is automatically decreased by the negativepressure control unit 130. On the other hand, in inhalation phase, the negative pressure is automatically increased by the negativepressure control unit 130. - The negative
pressure control unit 130 provides different negative pressure to a patient's oral cavity during a titrating period of time; and the said physiologicalstatus extraction unit 120 determines an optimized pressure setting with least breathing disorder events corresponding to a patient's breaths patterns. -
FIGS. 11A-11B andFIG. 11C show application diagrams and a flow chart in an example #10 of the embodiment to control the negative pressure according to HRV detection. InFIG. 11A thesensing unit 150 may he Electro-Cardiogram (ECG) electrodes for sensing electrical activity of the heart. InFIG. 11B , thesensing unit 150 may include a photoplethysmography (PPG) for sensing cardiac cycles. - Based on the sensing result of the
sensing unit 150, the physiologicalstatus extraction unit 120 determines HRV or whether heart rate is abnormal or stopped. UARS or OSA is associated with high heart rate variability, wherein heart rate variability may he resulted from apnea. Therefore, in example #10, if high HRV is detected, then the negative pressure is automatically controlled. - Now please refer to
FIG. 11C , if high HRV is detected (step 1110), then it is determined whether heart rate is abnormal or stopped (step 1120). If heart rate is abnormal or stopped, then a warning signal is generated and thenegative pressure source 140 is automatically turned off by the negativepressure control unit 130. If HRV is detected and heart rate is not stopped, then the negativepressure control unit 130 automatically controls the negative pressure (step 1140), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If high HRV does not occur (step 1110), then the negativepressure control unit 130 automatically controls the negative pressure (step 1150), for example to maintain the negative pressure, automatically decrease the negative pressure, or turn off the negative pressure. Further, instep - In example #10, the supplied negative pressure is adjusted based on whether HRV is over a threshold. If not, which means UARS or OSA may not occur, then the negative pressure is turned off or decreased, for reducing power consumption. If yes, which means UARS or OSA may occur, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 12A andFIG. 12B show an application diagram and a flow chart in an example #11 of the embodiment to control the negative pressure according to oral suction intent detection. InFIG. 12A , thesensing unit 150 may be a pressure sensor or a cannula connected to a pressure sensor for sensing pressure in an oral cavity. Based on the sensing result of thesensing unit 150, the physiologicalstatus extraction unit 120 determines oral suction intent. Further, if the pressure in oral cavity is decreased, then the physiologicalstatus extraction unit 120 determines intent in oral suction, which represents user's intent to provide negative pressure to the oral cavity. Therefore, in example #11, if oral suction intent is detected, then the negative pressure is automatically controlled. - Now please refer to
FIG. 12B , if oral suction intent s detected (step 1210), then the negativepressure control unit 130 automatically controls the negative pressure (step 1220), for example to turn on thenegative pressure source 140 or automatically increase the negative pressure. If no oral suction intent is detected (step 1210), then the negativepressure control unit 130 automatically controls the negative pressure (step 1230), for example to automatically turn off thenegative pressure source 140 or maintain the negative pressure. Further, instep 1220, the negative pressure may be increased by predetermined values. - In example #11, the negative pressure is adjusted based on oral suction intent. If no oral suction intent, which means a user has no intention to provide negative pressure to the oral cavity then the negative pressure is not turned on, for reducing power consumption. If oral suction intent is detected, which means a user has an intention to provide negative pressure to the oral cavity, then the
negative pressure source 140 is powered on or the negative pressure is increased, for providing negative pressure in oral cavity to improve the patency of upper airway. -
FIGS. 13A and 13B show an application diagram and a flow chart in an example #12 of the embodiment to control the negative pressure according to open mouth intent detection. InFIG. 13A , thesensing unit 150 may be electromyography electrodes for sensing electrical activity of muscles near mouth or jaw. Based on the sensing result of thesensing unit 150, the physiologicalstatus extraction unit 120 determines open mouth intent. Further, if open mouth intent is detected, which means a user have an intention to open mouth, providing negative pressure to the oral cavity is stopped. Therefore, in example #12, if open mouth intent is detected, then the negative pressure is automatically controlled. - Now please refer to
FIG. 13B , if open mouth intent is detected (step 1310), then the negativepressure control unit 130 automatically controls the negative pressure (step 1320), for example to turn off thenegative pressure source 140. If open mouth intent does not occur (step 1310), then the negativepressure control unit 130 automatically controls the negative pressure (step 1330), for example to maintain the negative pressure. - In example #12, the negative pressure is adjusted based on open mouth intent. If a user has an intention to open mouth, then the negative pressure is turned off, for reducing power consumption. If no open mouth intent is detected, then the negative pressure is maintained, for providing negative pressure in oral cavity to improve the patency of upper airway.
- In the above examples, the flow chart is performed periodically. Further, anyone of the examples would be modified and combined with other example. For example, but not limited, the example #2 would be modified and combined with the example #1, so that, if the a user is detected as being in asleep, then the body posture of a user asleep would be detected as those in the example 1, for further controlling the negative pressure.
- Example #13 of the application provides an oral appliance with automatic negative pressure control and a method therefore.
FIG. 14 shows a block diagram for the oral appliance with negative pressure for enhancing upper airway stability, in the example #13 of the exemplary embodiment to provide the time interval control The oral appliance with automatic negative pressure control includes: anegative pressure source 140, for providing a negative pressure; anoral interface 160, for connecting said negative pressure source and interfacing with an oral cavity, and a negativepressure control unit 130 for controlling said negative pressure source based on atime interval control 135, such as auto on, auto pressure increase, intermittent, and auto relaxation. Thenegative pressure source 140, the negativepressure control unit 130 and thetime interval control 135 are inside themain body 110. The negativepressure control unit 130 automatically turns the negative pressure on at a predetermined time interval after power on, under control of the time interval control. The negativepressure control unit 130 gradually increases the negative pressure to a predetermined value at a predetermined time interval after power on, under control of the time interval control. The negativepressure control unit 130 intermittently turns the negative pressure off and on at predetermined time periods, under control of the time interval control. The negativepressure control unit 130 periodically decreases the negative pressure to a low value for a predetermined time interval and then resuming to a high value, under control of the time interval control. - It will be appreciated by those skilled in the art that changes could be made to the disclosed embodiments described above without departing from the broad inventive concept thereof. It is understood, therefore, that the disclosed embodiments are not limited to the particular examples disclosed, but is intended to cover modifications within the spirit and scope of the disclosed embodiments as defined by the claims that follow.
Claims (23)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/079,687 US20140069435A1 (en) | 2008-10-29 | 2013-11-14 | Oral appliance with auto negative pressure control and method thereof |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10923908P | 2008-10-29 | 2008-10-29 | |
US12/561,364 US8616208B2 (en) | 2008-10-29 | 2009-09-17 | Oral appliance with auto negative pressure control and method thereof |
US14/079,687 US20140069435A1 (en) | 2008-10-29 | 2013-11-14 | Oral appliance with auto negative pressure control and method thereof |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/561,364 Division US8616208B2 (en) | 2008-10-29 | 2009-09-17 | Oral appliance with auto negative pressure control and method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
US20140069435A1 true US20140069435A1 (en) | 2014-03-13 |
Family
ID=42116289
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/561,364 Active 2032-08-03 US8616208B2 (en) | 2008-10-29 | 2009-09-17 | Oral appliance with auto negative pressure control and method thereof |
US14/079,687 Abandoned US20140069435A1 (en) | 2008-10-29 | 2013-11-14 | Oral appliance with auto negative pressure control and method thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/561,364 Active 2032-08-03 US8616208B2 (en) | 2008-10-29 | 2009-09-17 | Oral appliance with auto negative pressure control and method thereof |
Country Status (2)
Country | Link |
---|---|
US (2) | US8616208B2 (en) |
TW (1) | TWI448279B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017063824A (en) * | 2015-09-28 | 2017-04-06 | 株式会社アニモ | Information processing method and device |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012528698A (en) | 2009-06-05 | 2012-11-15 | ゼットエスティー ホールディングス, インコーポレイテッド | Orthosis and method for mandibular protrusion related applications |
BR112013015386B1 (en) * | 2010-12-21 | 2020-12-01 | Koninklijke Philips N.V. | system for controlling the expiratory air flow of a machine-induced patient |
US9162032B2 (en) | 2011-03-21 | 2015-10-20 | William Ray Lynch, JR. | Systems and methods for diagnosing and treating sleep disorders |
EP2797561A4 (en) | 2011-12-30 | 2016-03-09 | Zst Holdings Inc | Oral appliances and methods of use |
CA2876684C (en) * | 2012-06-13 | 2020-08-25 | Zst Holdings, Inc. | Methods and apparatuses for performing remote titration of mandibular protrusion |
AU2013296548B2 (en) * | 2012-08-01 | 2017-08-10 | Exactech, Inc. | Prosthetic devices to improve joint mechanics in arthroplasty |
JP6640075B2 (en) * | 2013-03-14 | 2020-02-05 | ゼスト・ホールディングス・インコーポレイテッド | System and method for providing automatic titration in oral device therapy |
US9655766B2 (en) * | 2013-03-15 | 2017-05-23 | Elwha Llc | Sleep-apnea-treatment system that changes the treatment pressure over a period that begins or ends at a settable time |
US10780017B2 (en) | 2013-03-15 | 2020-09-22 | Somne Llc | Treating sleep apnea with negative pressure |
CA2942023A1 (en) * | 2014-03-10 | 2015-09-17 | Zst Holdings, Inc. | Non-invasive systems and methods for identifying respiratory disturbances experienced by a subject |
KR102605278B1 (en) * | 2015-03-31 | 2023-11-23 | 피셔 앤 페이켈 핼스케어 리미티드 | Method and device for oxygen supply and/or CO2 removal |
EP3277163B1 (en) | 2015-03-31 | 2019-12-04 | ZST Holdings, Inc. | Systems for providing an automated titration for oral appliance therapy |
CN111603643B (en) | 2015-04-02 | 2023-05-23 | 希尔-罗姆服务私人有限公司 | Pressure control of breathing apparatus |
TWI561261B (en) * | 2015-05-08 | 2016-12-11 | Lead Data Inc | Breathing apparatus |
CA3062991A1 (en) * | 2017-05-15 | 2018-11-22 | Smith & Nephew Plc | Negative pressure wound therapy system using eulerian video magnification |
AU2018284233B2 (en) | 2017-06-14 | 2024-01-04 | Smith & Nephew, Inc. | Fluid removal management and control of wound closure in wound therapy |
WO2018231874A1 (en) * | 2017-06-14 | 2018-12-20 | Smith & Nephew, Inc. | Control of wound closure and fluid removal management in wound therapy |
IT201900007245A1 (en) * | 2019-05-27 | 2020-11-27 | Gabrio Ambrogio Polastri | FIXING DEVICE FOR MANAGEMENT DEVICES OF AIRWAYS, IN PARTICULAR ENDOTRACHEAL AND NASOTRACHEAL TUBES AND LARYNGEAL MASKS, PERFECTED. |
BR112022023107A2 (en) | 2020-05-21 | 2023-01-17 | Good News Medical Co Ltd | DEVICE TO RELIEVE OBSTRUCTIVE SLEEP APNEA |
WO2022112823A1 (en) * | 2020-11-25 | 2022-06-02 | Claudio Reverberi | Fixing device for intracorporeal access devices |
CN113143571B (en) * | 2021-05-21 | 2022-06-24 | 慕思健康睡眠股份有限公司 | Multi-person snore stopping mattress and snore stopping control method |
CN116115198A (en) * | 2023-04-19 | 2023-05-16 | 深圳启脉科技有限公司 | Low-power consumption snore automatic recording method and device based on physiological sign |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5970976A (en) * | 1998-03-31 | 1999-10-26 | Zhao; Hongwei | Apparatus and method for generating pressure changes in a mammalian oral/throat cavity |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617525A (en) * | 1984-01-30 | 1986-10-14 | Lloyd Stephen R | Sleep posture monitor and alarm system |
US5522382A (en) * | 1987-06-26 | 1996-06-04 | Rescare Limited | Device and method for treating obstructed breathing having a delay/ramp feature |
US6033326A (en) * | 1995-03-27 | 2000-03-07 | Richard M. Lee | Hockey stick with replaceable blade edge |
US5957133A (en) * | 1997-07-21 | 1999-09-28 | Hart; William T. | Oral appliance with negative air supply for reducing sleep apnea and snoring |
US6877513B2 (en) * | 2000-01-21 | 2005-04-12 | Respironics, Inc. | Intraoral apparatus for enhancing airway patency |
US6494209B2 (en) * | 2001-04-02 | 2002-12-17 | George Kulick | Method and apparatus for treatment of snoring, hypopnea and apnea |
US7168429B2 (en) * | 2001-10-12 | 2007-01-30 | Ric Investments, Llc | Auto-titration pressure support system and method of using same |
EP1670547B1 (en) * | 2003-08-18 | 2008-11-12 | Cardiac Pacemakers, Inc. | Patient monitoring system |
US20050166928A1 (en) * | 2004-01-30 | 2005-08-04 | Yandong Jiang | Methods and devices for maintaining an open airway |
US7798146B2 (en) * | 2004-10-29 | 2010-09-21 | Ric Investments, Llc | Oral appliance |
US7942824B1 (en) * | 2005-11-04 | 2011-05-17 | Cleveland Medical Devices Inc. | Integrated sleep diagnostic and therapeutic system and method |
US7918222B2 (en) * | 2006-05-30 | 2011-04-05 | Industrial Technology Research Institute | Method and apparatus for treating obstructive sleep apnea by using negative oral pressure to a patient |
EP2478931B1 (en) | 2006-10-13 | 2015-12-30 | Cyberonics, Inc. | Obstructive sleep apnea treatment device |
TWI365253B (en) | 2008-05-20 | 2012-06-01 | Ind Tech Res Inst | Thin electromagnetic actuator and pump using the same |
TWI396526B (en) * | 2008-05-20 | 2013-05-21 | Ind Tech Res Inst | Oral interface apparatus with negative pressure and method for maintianing oral negative pressure and collecting saliva |
-
2009
- 2009-09-17 US US12/561,364 patent/US8616208B2/en active Active
- 2009-10-29 TW TW098136668A patent/TWI448279B/en active
-
2013
- 2013-11-14 US US14/079,687 patent/US20140069435A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5970976A (en) * | 1998-03-31 | 1999-10-26 | Zhao; Hongwei | Apparatus and method for generating pressure changes in a mammalian oral/throat cavity |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017063824A (en) * | 2015-09-28 | 2017-04-06 | 株式会社アニモ | Information processing method and device |
Also Published As
Publication number | Publication date |
---|---|
US20100101583A1 (en) | 2010-04-29 |
US8616208B2 (en) | 2013-12-31 |
TWI448279B (en) | 2014-08-11 |
TW201016202A (en) | 2010-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8616208B2 (en) | Oral appliance with auto negative pressure control and method thereof | |
US9682206B2 (en) | Session-by-session adjustment of a device for treating sleep disordered breathing | |
US20090151719A1 (en) | Methods and devices for treating sleep apnea | |
US20110065979A1 (en) | System and method for training and promoting a conditioned reflex intervention during sleep | |
US20140123977A1 (en) | Sleep-activated cpap machine | |
JP2021529019A (en) | Systems and methods for providing enhanced PAP metrics | |
US11298486B2 (en) | Systems and methods for concurrent airway stabilization and pulmonary stretch receptor activation | |
JP6496024B2 (en) | Heart failure treatment device | |
US20220203056A1 (en) | Systems and methods for concurrent airway stabilization and pulmonary stretch receptor activation | |
US20220203052A1 (en) | Systems and methods for concurrent airway stabilization and pulmonary stretch receptor activation | |
JP7381507B2 (en) | Systems and methods for increasing compliance with pressure support therapy | |
AU2012216551B2 (en) | Session-By-Session Adjustment of a Device for Treating Sleep Disordered Breathing | |
US11458268B2 (en) | Systems and methods for concurrent airway stabilization and pulmonary stretch receptor activation | |
WO2023187686A1 (en) | Systems and methods for determining a positional sleep disordered breathing status |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, TAIWAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CHEN, CHUNG-CHU;LIN, CHEN-LIANG;HUANG, CHEN-NING;AND OTHERS;REEL/FRAME:031599/0015 Effective date: 20131107 |
|
AS | Assignment |
Owner name: SOMNICS, INC., TAIWAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE;REEL/FRAME:036943/0339 Effective date: 20151023 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |