US20130324931A1 - Drug Delivery And Diagnostic System For Orthopedic Implants - Google Patents
Drug Delivery And Diagnostic System For Orthopedic Implants Download PDFInfo
- Publication number
- US20130324931A1 US20130324931A1 US13/959,164 US201313959164A US2013324931A1 US 20130324931 A1 US20130324931 A1 US 20130324931A1 US 201313959164 A US201313959164 A US 201313959164A US 2013324931 A1 US2013324931 A1 US 2013324931A1
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- United States
- Prior art keywords
- conduit
- drug delivery
- diagnostic system
- attachment surface
- outer attachment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 49
- 230000000399 orthopedic effect Effects 0.000 title claims abstract description 48
- 238000007920 subcutaneous administration Methods 0.000 claims abstract description 26
- 239000012530 fluid Substances 0.000 claims abstract description 22
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 2
- 210000000689 upper leg Anatomy 0.000 description 9
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Images
Classifications
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Definitions
- the present disclosure relates generally to orthopedic implants and more specifically to orthopedic implants having a drug delivery and diagnostic system.
- Orthopedic implants have been used to partially or entirely replace bones and joints that may be damaged. In some examples however, infection on or near such orthopedic implants may take place after implantation of the orthopedic prosthesis. Moreover, the onset of infection on or near the orthopedic implant and tissue interface may be difficult to detect. Furthermore, the type of infecting agent may also be unknown. In some examples, once an infection is eventually detected, the recourse may be invasive and include extraction of the orthopedic implant and subsequent revision surgery. To address such concerns drug coated orthopedic implants have been developed. Drug coated orthopedic implants provide a coating on the implant to be effective against various bacteria and strain. Drug coated implants are generally most effective immediately after implantation of the orthopedic implant, such as when the eluting mechanism is activated upon contact with bodily fluid.
- a drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface.
- a conduit can be coupled to the outer attachment surface.
- the conduit can have an inlet and a plurality of perforations formed along a length thereof.
- the conduit can be adapted to pass fluid between the inlet and the perforations.
- a subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
- the conduit can be spirally wrapped around the outer attachment surface.
- the conduit can be formed of biocompatible metal or polymer.
- the conduit can be attached to the outer attachment surface, such as by welding, brazing or gluing.
- a drug delivery system can comprise an orthopedic implant having a blind bore formed thereon and at least one passage that fluidly connects the blind bore with an outer surface of the orthopedic implant.
- An implant module can have a reservoir, a first radio frequency (RF) receiver, a fluid reservoir, and a valve that is selectively movable from a closed position wherein fluid is retained in the reservoir and an open position wherein the fluid is communicated out of the reservoir.
- the implant module can have an insertion end that is adapted to couple to the orthopedic implant at the blind bore.
- a handheld device having a second RF transmitter can communicate with the first RF receiver. The handheld device can be operable to send a signal from the second RF transmitter.
- the first RF receiver is operable to initiate movement of the valve to the open position upon receipt of the signal from the second RF transmitter.
- FIG. 1 is a perspective posterior view of a femoral stem implanted in an intramedullary canal of a right femur, the femoral stem incorporating the drug delivery and diagnostic system of the present teachings;
- FIG. 2 is an exploded perspective view of the drug delivery and diagnostic system of FIG. 1 ;
- FIG. 3 is a perspective view of a drug delivery and diagnostic system according to additional features of the present teachings
- FIG. 4 is a sectional view of the drug delivery and diagnostic system taken along lines 4 - 4 of FIG. 1 and shown prior to insertion of a needle into a subcutaneous port implanted below the skin of a patient;
- FIG. 5 is a cross-sectional view of the drug delivery and diagnostic system of FIG. 4 and shown subsequent to delivery of fluid through respective passages formed in the femoral stem;
- FIG. 6 is an exploded view of a drug delivery system constructed in accordance to additional features of the present disclosure and including a remote handheld device;
- FIG. 7 is a perspective view of an acetabular cup incorporating a drug delivery and diagnostic system according to additional features of the present teachings.
- FIG. 8 is a perspective view of a tibial tray incorporating a drug delivery and diagnostic system according to other features of the present disclosure.
- FIGS. 1-6 While a femoral stem is shown in FIGS. 1-6 , other implants such as acetabular cups ( FIG. 7 ), tibial trays ( FIG. 8 ) and others may be used in conjunction with the disclosed system.
- implants such as acetabular cups ( FIG. 7 ), tibial trays ( FIG. 8 ) and others may be used in conjunction with the disclosed system.
- the drug delivery and diagnostic system 10 can generally include an orthopedic implant 12 , a subcutaneous port 14 , a flexible catheter 16 and an adapter 18 .
- the orthopedic implant is in the form of a femoral stem 20 .
- a syringe 22 having a plunger 24 and a needle 26 can be used with the subcutaneous port 14 , the flexible catheter 16 and the adapter 18 in a first sequence to assist in diagnosing an infection that may be present in the surrounding tissue adjacent the orthopedic implant 12 .
- the syringe 22 , plunger 24 and needle 26 can also be used with the subcutaneous port 14 , the catheter 16 and adapter 18 in a second sequence to deliver drugs, such as antibiotics, cellular therapy including stem cells, such as from fat or bone marrow aspirate, autologous blood components or other flowable therapies to the surrounding tissue adjacent the orthopedic implant 12 .
- drugs such as antibiotics, cellular therapy including stem cells, such as from fat or bone marrow aspirate, autologous blood components or other flowable therapies to the surrounding tissue adjacent the orthopedic implant 12 .
- the femoral stem 20 is shown implanted into an intramedullary canal 28 of a femur 30 .
- the femoral stem 20 can generally comprise a body 32 having a proximal body portion 34 and a distal stem portion 36 .
- a blind bore or inserter hole 38 can be formed on the proximal body portion 34 .
- the inserter hole 38 can be tapered and have threads 40 formed around an inner diameter thereof.
- the inserter hole 38 can be used for coupling with an inserter tool (not shown) during insertion of the femoral stem 20 into the intramedullary canal of the femur 30 .
- the femoral stem 20 can further include a fluid passage system 40 that can include a primary passage 42 that is fluidly coupled to the inserter hole 38 and to a series of secondary passages 44 defined within the implant 12 .
- the secondary passages 44 can extend to an outer surface 46 of the femoral stem 20 .
- six secondary passages 44 are illustrated in the exemplary configuration of FIG. 1 .
- additional or fewer secondary passages can be provided in the femoral stem 20 that fluidly connects the primary passage 42 with the outer surface 46 .
- the secondary passages 44 can be formed at right angles or non-orthogonal angles with respect to the primary passage 42 and a long axis of the femur 30 .
- the proximal body portion 34 can further comprise a neck 50 having a male taper 52 . While not specifically shown, the male taper 52 can be operable to couple with a femoral head as is known in the art.
- the adapter 18 can generally comprise an adapter body 54 having a longitudinal tapered insertion end 56 that has adapter threads 58 formed around an outer surface.
- An adapter nipple 60 can extend on an opposite end of the adapter body 54 .
- the adapter nipple 60 can include a rib 62 thereon.
- the subcutaneous port 14 can generally comprise a port body 64 that has an artificial septum 66 arranged thereon.
- a subcutaneous port nipple 68 can extend from the body 64 .
- a rib 70 can be formed around the subcutaneous port nipple 68 . It will be appreciated that the subcutaneous port 14 can take other forms.
- the catheter 16 can be operable to be slidably advanced at opposite terminal ends onto the adapter nipple 60 and the subcutaneous port nipple 68 , respectively.
- the catheter 16 can be coated with and/or made with antifouling (antibacterial) material.
- the adapter threads 58 can be threadably advanced into the inserter hole 38 at the proximal body portion 34 of the femoral stem 20 .
- the adapter threads 58 threadably advance around the threads 40 provided in the inserter hole 38 .
- the ends of the catheter 16 can be slidably advanced into a secure relationship with the respective adapter nipple 60 and subcutaneous port nipple 68 .
- the catheter 16 can comprise any length suitable for a particular patient that allows the subcutaneous port 14 to be implanted under skin 74 ( FIGS. 1 and 4 ) at a convenient access area of the patient.
- the drug delivery and diagnostic system 110 can include a flexible pipe or conduit 112 that is wrapped around a groove 121 formed in an outer attachment surface 114 of a femoral stem 120 . It is appreciated that the groove 121 may extend further superiorly up the neck of the femoral stem 120 . The groove 121 can have a depth such that the conduit 112 does not extend past the outer attachment surface.
- the conduit 112 can generally comprise a plurality of perforations 122 along its length. In other examples, the conduit 112 can include one or a series of linear or substantially linear pipes that branch out and extend along the outer attachment surface 114 .
- the conduit 112 can be formed of biocompatible metallic material and can be attached to the outer attachment surface 114 (or more specifically into the groove 121 ), such as by a welding or brazing technique.
- the conduit can alternatively be formed of a polymer and attached to the groove 121 by an adhesive such as glue.
- the drug delivery and diagnostic system 110 can cooperate with the subcutaneous port 14 and the syringe 12 to deliver therapy and/or extract bodily fluid during a diagnostic test as discussed with respect to the drug delivery and diagnostic system 10 herein.
- the drug delivery and diagnostic system 10 will be used to diagnose potential bacteria that may be present at an interface between the femoral stem 20 and the femur 30 .
- the surgeon can draw fluid from a container (not shown), such as saline into the syringe 22 .
- the surgeon can pierce the skin 74 of the patient and pierce the artificial septum 66 of the subcutaneous port 14 .
- the plunger 24 can then be depressed, such that the saline communicates through the catheter 16 and through the adapter 18 , through the primary and secondary passages 42 and 44 and ultimately into the surrounding tissue around the outer surface 46 of the femoral stem 20 .
- the saline can act to dislodge bacteria and therefore mix with any potential bacteria.
- a surgeon can retract the plunger 24 and aspirate the saline and the bodily fluid that surrounds the outer surface 46 .
- the resultant mixture can then be cultured to determine if any bacteria (and specific type etc.) is present in the suspected infection site around the outer surface 46 of the femoral stem 20 .
- the drug delivery and diagnostic system 10 will be described in accordance to a second method where the syringe 22 can be used to deliver a therapy, such as drugs, cellular therapy and/or autologous blood components to the implant-tissue interface.
- a therapy such as drugs, cellular therapy and/or autologous blood components
- the drug delivery and diagnostic system can be used at any time, such as immediately after implantation of the femoral stem 20 or at any time, such as a year or many years after implantation of the femoral stem 20 .
- the surgeon can pierce the artificial septum 66 of the subcutaneous port 14 with the needle 26 and depress the plunger 24 to deliver the flowable agent through the catheter 16 , through the adapter 18 and through the respective primary and secondary passages 42 and 44 .
- This enables the drug to be delivered around a perimeter of implant 12 at the infection site.
- the system can therefore be more efficient and effective compared to medications taken orally or intravenously.
- the drug delivery system 210 can generally include an orthopedic implant 212 , an implant module 214 and a handheld device 216 .
- the orthopedic prosthesis 212 can be constructed similarly to the femoral stem 20 described in detail above.
- the drug delivery system 210 is operable to remotely communicate with the implant module 214 , such that flowable material, such as antibiotics housed in the implant module 214 can be delivered to the tissue interface between the orthopedic prosthesis 212 and the femur 220 .
- the implant module 214 can generally comprise an insertion end 222 having module threads 224 .
- the module threads 224 can be configured to threadably mate with blind bore threads 226 provided on an inserter hole 230 of the orthopedic implant 212 .
- the implant module 214 can further comprise a reservoir 232 , a valve 234 , an actuator 236 and a first radio frequency (RF) receiver 238 .
- the handheld device 216 can generally comprise a housing 240 having a display 242 , an interface panel 244 and a second RF transmitter 248 .
- a signal can be communicated from the second RF transmitter 248 of the handheld device 216 .
- the first RF receiver 238 can communicate with the actuator 236 to cause the actuator 236 to open the valve 234 from a closed position to an open position wherein antibiotics (or other fluid) can be communicated through the primary passage 256 and secondary passages 258 and to the tissue interface between the orthopedic prosthesis 212 and the femur 220 .
- an orthopedic implant 312 that incorporates respective passages 314 is shown.
- the orthopedic prosthesis 312 is in the form of an acetabular cup 320 .
- the orthopedic prosthesis 312 can be used with other components described herein, such as the subcutaneous port 14 , the catheter 16 and the syringe 22 .
- the acetabular cup 320 can be used in a similar fashion as the femoral stem 20 described above. In this way, the fluid passages 314 can be used to assist in diagnosing a potential infection and/or to deliver antibiotic or other flowable material to an outer surface of the acetabular cup 320 .
- an orthopedic prosthesis 330 is shown that incorporates fluid passage 332 .
- the orthopedic prosthesis 330 is in the form of a tibial tray 334 .
- the orthopedic prosthesis 330 can be used with other components described herein, such as the subcutaneous port 14 , the catheter 16 , and the syringe 22 .
- the fluid passage 332 can be used to assist in diagnosing a potential infection around the tibial tray 34 , such as by one of the methods described above.
- the fluid passage 332 can be used to deliver antibiotics or other flowable material to an outer surface of the tibial tray.
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Abstract
A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
Description
- This application is a divisional of U.S. patent application Ser. No. 13/039,362 filed Mar. 3, 2011, which claims the benefit of U.S. Provisional Application No. 61/311,096 filed Mar. 5, 2010. The entire disclosures of the above applications are incorporated herein by reference.
- The present disclosure relates generally to orthopedic implants and more specifically to orthopedic implants having a drug delivery and diagnostic system.
- This section provides background information related to the present disclosure which is not necessarily prior art.
- Orthopedic implants have been used to partially or entirely replace bones and joints that may be damaged. In some examples however, infection on or near such orthopedic implants may take place after implantation of the orthopedic prosthesis. Moreover, the onset of infection on or near the orthopedic implant and tissue interface may be difficult to detect. Furthermore, the type of infecting agent may also be unknown. In some examples, once an infection is eventually detected, the recourse may be invasive and include extraction of the orthopedic implant and subsequent revision surgery. To address such concerns drug coated orthopedic implants have been developed. Drug coated orthopedic implants provide a coating on the implant to be effective against various bacteria and strain. Drug coated implants are generally most effective immediately after implantation of the orthopedic implant, such as when the eluting mechanism is activated upon contact with bodily fluid.
- This section provides a general summary of the disclosure, and is not a comprehensive disclosure of its full scope or all of its features.
- A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
- According to additional features, the conduit can be spirally wrapped around the outer attachment surface. The conduit can be formed of biocompatible metal or polymer. The conduit can be attached to the outer attachment surface, such as by welding, brazing or gluing.
- According to other features, a drug delivery system can comprise an orthopedic implant having a blind bore formed thereon and at least one passage that fluidly connects the blind bore with an outer surface of the orthopedic implant. An implant module can have a reservoir, a first radio frequency (RF) receiver, a fluid reservoir, and a valve that is selectively movable from a closed position wherein fluid is retained in the reservoir and an open position wherein the fluid is communicated out of the reservoir. The implant module can have an insertion end that is adapted to couple to the orthopedic implant at the blind bore. A handheld device having a second RF transmitter can communicate with the first RF receiver. The handheld device can be operable to send a signal from the second RF transmitter. The first RF receiver is operable to initiate movement of the valve to the open position upon receipt of the signal from the second RF transmitter.
- Further areas of applicability will become apparent from the description provided herein. The description and specific examples in this summary are intended for purposes of illustration only and are not intended to limit the scope of the present disclosure.
- The drawings described herein are for illustrative purposes only of selected embodiments and not all possible implementations, and are not intended to limit the scope of the present disclosure.
-
FIG. 1 is a perspective posterior view of a femoral stem implanted in an intramedullary canal of a right femur, the femoral stem incorporating the drug delivery and diagnostic system of the present teachings; -
FIG. 2 is an exploded perspective view of the drug delivery and diagnostic system ofFIG. 1 ; -
FIG. 3 is a perspective view of a drug delivery and diagnostic system according to additional features of the present teachings; -
FIG. 4 is a sectional view of the drug delivery and diagnostic system taken along lines 4-4 ofFIG. 1 and shown prior to insertion of a needle into a subcutaneous port implanted below the skin of a patient; -
FIG. 5 is a cross-sectional view of the drug delivery and diagnostic system ofFIG. 4 and shown subsequent to delivery of fluid through respective passages formed in the femoral stem; -
FIG. 6 is an exploded view of a drug delivery system constructed in accordance to additional features of the present disclosure and including a remote handheld device; -
FIG. 7 is a perspective view of an acetabular cup incorporating a drug delivery and diagnostic system according to additional features of the present teachings; and -
FIG. 8 is a perspective view of a tibial tray incorporating a drug delivery and diagnostic system according to other features of the present disclosure. - Corresponding reference numerals indicate corresponding parts throughout the several views of the drawings.
- Example embodiments will now be described more fully with reference to the accompanying drawings. While a femoral stem is shown in
FIGS. 1-6 , other implants such as acetabular cups (FIG. 7 ), tibial trays (FIG. 8 ) and others may be used in conjunction with the disclosed system. - With initial reference to
FIGS. 1 and 2 , a drug delivery and diagnostic system constructed in accordance to one example of the present teachings is shown and generally identified atreference numeral 10. The drug delivery anddiagnostic system 10 can generally include anorthopedic implant 12, asubcutaneous port 14, aflexible catheter 16 and anadapter 18. As illustrated, the orthopedic implant is in the form of afemoral stem 20. As will be described in greater detail herein, asyringe 22 having aplunger 24 and aneedle 26 can be used with thesubcutaneous port 14, theflexible catheter 16 and theadapter 18 in a first sequence to assist in diagnosing an infection that may be present in the surrounding tissue adjacent theorthopedic implant 12. Thesyringe 22,plunger 24 andneedle 26 can also be used with thesubcutaneous port 14, thecatheter 16 andadapter 18 in a second sequence to deliver drugs, such as antibiotics, cellular therapy including stem cells, such as from fat or bone marrow aspirate, autologous blood components or other flowable therapies to the surrounding tissue adjacent theorthopedic implant 12. - As shown in
FIG. 1 , thefemoral stem 20 is shown implanted into anintramedullary canal 28 of afemur 30. As best shown inFIG. 2 , thefemoral stem 20 can generally comprise abody 32 having aproximal body portion 34 and adistal stem portion 36. A blind bore orinserter hole 38 can be formed on theproximal body portion 34. Theinserter hole 38 can be tapered and havethreads 40 formed around an inner diameter thereof. Theinserter hole 38 can be used for coupling with an inserter tool (not shown) during insertion of thefemoral stem 20 into the intramedullary canal of thefemur 30. Thefemoral stem 20 can further include afluid passage system 40 that can include aprimary passage 42 that is fluidly coupled to theinserter hole 38 and to a series ofsecondary passages 44 defined within theimplant 12. Thesecondary passages 44 can extend to anouter surface 46 of thefemoral stem 20. By way of example, sixsecondary passages 44 are illustrated in the exemplary configuration ofFIG. 1 . However, it will be appreciated that additional or fewer secondary passages can be provided in thefemoral stem 20 that fluidly connects theprimary passage 42 with theouter surface 46. Furthermore, it will be appreciated that thesecondary passages 44 can be formed at right angles or non-orthogonal angles with respect to theprimary passage 42 and a long axis of thefemur 30. Theproximal body portion 34 can further comprise aneck 50 having amale taper 52. While not specifically shown, themale taper 52 can be operable to couple with a femoral head as is known in the art. Theadapter 18 can generally comprise anadapter body 54 having a longitudinal taperedinsertion end 56 that hasadapter threads 58 formed around an outer surface. Anadapter nipple 60 can extend on an opposite end of theadapter body 54. Theadapter nipple 60 can include arib 62 thereon. - The
subcutaneous port 14 can generally comprise a port body 64 that has anartificial septum 66 arranged thereon. Asubcutaneous port nipple 68 can extend from the body 64. Arib 70 can be formed around thesubcutaneous port nipple 68. It will be appreciated that thesubcutaneous port 14 can take other forms. Thecatheter 16 can be operable to be slidably advanced at opposite terminal ends onto theadapter nipple 60 and thesubcutaneous port nipple 68, respectively. Thecatheter 16 can be coated with and/or made with antifouling (antibacterial) material. - In one example of assembling the
adapter 18 to thefemoral stem 20, theadapter threads 58 can be threadably advanced into theinserter hole 38 at theproximal body portion 34 of thefemoral stem 20. In this regard, theadapter threads 58 threadably advance around thethreads 40 provided in theinserter hole 38. Again, the ends of thecatheter 16 can be slidably advanced into a secure relationship with therespective adapter nipple 60 andsubcutaneous port nipple 68. It will be appreciated that thecatheter 16 can comprise any length suitable for a particular patient that allows thesubcutaneous port 14 to be implanted under skin 74 (FIGS. 1 and 4 ) at a convenient access area of the patient. - Turning now to
FIG. 3 , a drug delivery anddiagnostic system 110 constructed in accordance to additional features of the present teachings is shown. In general, the drug delivery anddiagnostic system 110 can include a flexible pipe orconduit 112 that is wrapped around agroove 121 formed in anouter attachment surface 114 of afemoral stem 120. It is appreciated that thegroove 121 may extend further superiorly up the neck of thefemoral stem 120. Thegroove 121 can have a depth such that theconduit 112 does not extend past the outer attachment surface. Theconduit 112 can generally comprise a plurality ofperforations 122 along its length. In other examples, theconduit 112 can include one or a series of linear or substantially linear pipes that branch out and extend along theouter attachment surface 114. In one example, theconduit 112 can be formed of biocompatible metallic material and can be attached to the outer attachment surface 114 (or more specifically into the groove 121), such as by a welding or brazing technique. The conduit can alternatively be formed of a polymer and attached to thegroove 121 by an adhesive such as glue. The drug delivery anddiagnostic system 110 can cooperate with thesubcutaneous port 14 and thesyringe 12 to deliver therapy and/or extract bodily fluid during a diagnostic test as discussed with respect to the drug delivery anddiagnostic system 10 herein. - With reference now to
FIGS. 4 and 5 , a first method of using the drug delivery anddiagnostic system 10 will be described. In the first method according to the present teachings, the drug delivery anddiagnostic system 10 will be used to diagnose potential bacteria that may be present at an interface between thefemoral stem 20 and thefemur 30. At the outset, the surgeon can draw fluid from a container (not shown), such as saline into thesyringe 22. Next, the surgeon can pierce theskin 74 of the patient and pierce theartificial septum 66 of thesubcutaneous port 14. Theplunger 24 can then be depressed, such that the saline communicates through thecatheter 16 and through theadapter 18, through the primary andsecondary passages outer surface 46 of thefemoral stem 20. At this point, the saline can act to dislodge bacteria and therefore mix with any potential bacteria. Next, a surgeon can retract theplunger 24 and aspirate the saline and the bodily fluid that surrounds theouter surface 46. The resultant mixture can then be cultured to determine if any bacteria (and specific type etc.) is present in the suspected infection site around theouter surface 46 of thefemoral stem 20. - With specific reference now to
FIG. 5 , the drug delivery anddiagnostic system 10 will be described in accordance to a second method where thesyringe 22 can be used to deliver a therapy, such as drugs, cellular therapy and/or autologous blood components to the implant-tissue interface. Again, it will be appreciated that with the first or second method, the drug delivery and diagnostic system can be used at any time, such as immediately after implantation of thefemoral stem 20 or at any time, such as a year or many years after implantation of thefemoral stem 20. Once the surgeon has determined what flowable agent is desired to be communicated to the interface of thefemoral stem 20 andfemur 30, the surgeon can pierce theartificial septum 66 of thesubcutaneous port 14 with theneedle 26 and depress theplunger 24 to deliver the flowable agent through thecatheter 16, through theadapter 18 and through the respective primary andsecondary passages implant 12 at the infection site. The system can therefore be more efficient and effective compared to medications taken orally or intravenously. - With specific reference now to
FIG. 6 , adrug delivery system 210 constructed in accordance to additional features of the present teachings is shown. Thedrug delivery system 210 can generally include anorthopedic implant 212, animplant module 214 and ahandheld device 216. Unless otherwise described herein, theorthopedic prosthesis 212 can be constructed similarly to thefemoral stem 20 described in detail above. In general, thedrug delivery system 210 is operable to remotely communicate with theimplant module 214, such that flowable material, such as antibiotics housed in theimplant module 214 can be delivered to the tissue interface between theorthopedic prosthesis 212 and thefemur 220. - The
implant module 214 can generally comprise aninsertion end 222 havingmodule threads 224. As with theadapter 18 described above, themodule threads 224 can be configured to threadably mate withblind bore threads 226 provided on aninserter hole 230 of theorthopedic implant 212. Theimplant module 214 can further comprise areservoir 232, avalve 234, anactuator 236 and a first radio frequency (RF)receiver 238. Thehandheld device 216 can generally comprise ahousing 240 having adisplay 242, aninterface panel 244 and asecond RF transmitter 248. - One exemplary method of using the
drug delivery system 210 will now be described. Once a surgeon, medical professional or patient has determined that antibiotics (or other flowable material described herein) is desired to be communicated to a tissue interface between theorthopedic prosthesis 212 and thefemur 220, a signal can be communicated from thesecond RF transmitter 248 of thehandheld device 216. Upon receipt of the signal sent from thesecond RF transmitter 248, thefirst RF receiver 238 can communicate with theactuator 236 to cause theactuator 236 to open thevalve 234 from a closed position to an open position wherein antibiotics (or other fluid) can be communicated through theprimary passage 256 andsecondary passages 258 and to the tissue interface between theorthopedic prosthesis 212 and thefemur 220. - Turning now to
FIG. 7 , anorthopedic implant 312 that incorporatesrespective passages 314 is shown. As illustrated, theorthopedic prosthesis 312 is in the form of anacetabular cup 320. Theorthopedic prosthesis 312 can be used with other components described herein, such as thesubcutaneous port 14, thecatheter 16 and thesyringe 22. As can be appreciated, theacetabular cup 320 can be used in a similar fashion as thefemoral stem 20 described above. In this way, thefluid passages 314 can be used to assist in diagnosing a potential infection and/or to deliver antibiotic or other flowable material to an outer surface of theacetabular cup 320. - As shown in
FIG. 8 , anorthopedic prosthesis 330 is shown that incorporatesfluid passage 332. Theorthopedic prosthesis 330 is in the form of atibial tray 334. As can be appreciated, theorthopedic prosthesis 330 can be used with other components described herein, such as thesubcutaneous port 14, thecatheter 16, and thesyringe 22. In this regard, thefluid passage 332 can be used to assist in diagnosing a potential infection around thetibial tray 34, such as by one of the methods described above. Similarly, thefluid passage 332 can be used to deliver antibiotics or other flowable material to an outer surface of the tibial tray. - The foregoing description of the embodiments has been provided for purposes of illustration and description. It is not intended to be exhaustive or to limit the disclosure. Individual elements or features of a particular embodiment are generally not limited to that particular embodiment, but, where applicable, are interchangeable and can be used in a selected embodiment, even if not specifically shown or described. The same may also be varied in many ways. Such variations are not to be regarded as a departure from the disclosure, and all such modifications are intended to be included within the scope of the disclosure.
Claims (22)
1. A drug delivery and diagnostic system comprising:
an orthopedic implant having an outer attachment surface;
a conduit coupled to the outer attachment surface, the conduit having an inlet and at least one perforation formed thereon, the conduit adapted to pass fluid between the inlet and the at least one perforation; and
a subcutaneous port fluidly coupled to the inlet, wherein the subcutaneous port is adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.
2. The drug delivery and diagnostic system of claim 1 , wherein the conduit is spirally wrapped around the outer attachment surface.
3. The drug delivery and diagnostic system of claim 2 , wherein the conduit is formed of biocompatible metal.
4. The drug delivery and diagnostic system of claim 3 , wherein the conduit is one of welded, brazed or glued to the outer attachment surface.
5. The drug delivery and diagnostic system of claim 1 , wherein the at least one perforation includes a plurality of perforations formed along a length of the conduit.
6. The drug delivery and diagnostic system of claim 1 , wherein the orthopedic implant comprises a femoral hip stem having a groove formed there along, the groove formed on the outer attachment surface.
7. The drug delivery and diagnostic system of claim 6 , wherein the conduit nests in the groove.
8. The drug delivery and diagnostic system of claim 1 , wherein the outer attachment surface includes a groove formed in an outer surface of the orthopedic implant.
9. The drug delivery and diagnostic system of claim 8 , wherein the orthopedic implant is a femoral stem and the groove extends along a stem portion and a neck portion of the femoral stem.
10. A drug delivery and diagnostic system comprising:
an orthopedic implant having an outer attachment surface;
a conduit extending along the orthopedic implant and having an inlet and at least one outlet formed thereon, the conduit adapted to pass fluid between the inlet and the at least one outlet; and
a subcutaneous port fluidly coupled to the inlet, wherein the subcutaneous port is adapted to communicate fluid through the inlet, along the conduit, and through the at least one outlet.
11. The drug delivery and diagnostic system of claim 10 , wherein the conduit is coupled to the outer attachment surface.
12. The drug delivery and diagnostic system of claim 11 , wherein the outer attachment surface includes a groove formed therein.
13. The drug delivery and diagnostic system of claim 10 , wherein the at least one outlet includes at least one perforation formed through the conduit.
14. The drug delivery and diagnostic system of claim 10 , wherein the at least one outlet includes at least one substantially linear pipe that branches out and extend along the outer attachment surface.
15. The drug delivery and diagnostic system of claim 10 , further comprising:
a syringe to fluidly communicate with the subcutaneous port.
16. The drug delivery and diagnostic system of claim 10 , wherein the outer attachment surface extends around the orthopedic implant and the conduit is spirally wrapped around the orthopedic implant and coupled to the outer attachment surface.
17. A drug delivery and diagnostic system comprising:
an orthopedic implant having an outer attachment surface comprising a groove formed in the outer attachment surface and extending around the orthopedic implant;
a conduit extending along the orthopedic implant and having an inlet and at least one outlet formed thereon, the conduit adapted to pass fluid between the inlet and the at least one outlet; and
a subcutaneous port fluidly coupled to the inlet, wherein the subcutaneous port is adapted to communicate fluid through the inlet, along the conduit, and through the at least one outlet;
wherein the conduit is coupled with the outer attachment surface.
18. The drug delivery and diagnostic system of claim 17 , wherein the conduit is spirally wrapped around the orthopedic implant and coupled within the groove.
19. The drug delivery and diagnostic system of claim 17 , wherein the conduit is positioned in the groove and the groove has a depth such that the conduit does not extend past the outer attachment surface.
20. The drug delivery and diagnostic system of claim 17 , wherein the at least one outlet is selected from a group comprising a perforation or a substantially linear pipe that branches out and extends along the outer attachment surface.
21. The drug delivery and diagnostic system of claim 17 , wherein the orthopedic implant includes a femoral stem.
22. The drug delivery and diagnostic system of claim 17 , wherein the conduit and the subcutaneous port are configured to at least one of deliver a therapy or extract fluid.
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US13/959,164 US20130324931A1 (en) | 2010-03-05 | 2013-08-05 | Drug Delivery And Diagnostic System For Orthopedic Implants |
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2011
- 2011-03-03 US US13/039,362 patent/US8500819B2/en active Active
- 2011-03-04 DE DE102011005150A patent/DE102011005150A1/en not_active Withdrawn
- 2011-03-04 GB GB1513197.2A patent/GB2527945B/en not_active Expired - Fee Related
- 2011-03-04 GB GB1103663A patent/GB2478425A/en not_active Withdrawn
- 2011-03-04 JP JP2011047706A patent/JP5698037B2/en not_active Expired - Fee Related
-
2013
- 2013-08-05 US US13/959,164 patent/US20130324931A1/en not_active Abandoned
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WO2000048535A1 (en) * | 1999-02-19 | 2000-08-24 | Grimes James B | Bone prosthesis and method of implantation |
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US20050171593A1 (en) * | 2004-01-30 | 2005-08-04 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
US20070179609A1 (en) * | 2006-01-27 | 2007-08-02 | Medicinelodge, Inc. | Therapeutic agent eluding implant with percutaneous supply |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10716674B2 (en) | 2014-11-07 | 2020-07-21 | Smed-Ta/Td, Llc | Implants with groove patterns and soft tissue attachment features |
AU2020217365B2 (en) * | 2014-11-13 | 2022-02-03 | PAVmed Inc. | Intraosseous infusion ports and methods of use |
AU2019201519B1 (en) * | 2018-03-21 | 2019-07-11 | Heraeus Medical Gmbh | Knee spacer system with irrigation device |
US10864314B2 (en) | 2018-03-21 | 2020-12-15 | Heraeus Medical Gmbh | Knee spacer system with irrigation device |
Also Published As
Publication number | Publication date |
---|---|
GB201513197D0 (en) | 2015-09-09 |
US20110218644A1 (en) | 2011-09-08 |
JP2011200644A (en) | 2011-10-13 |
JP5698037B2 (en) | 2015-04-08 |
US8500819B2 (en) | 2013-08-06 |
DE102011005150A1 (en) | 2012-02-16 |
GB2527945B (en) | 2016-07-20 |
GB201103663D0 (en) | 2011-04-13 |
GB2527945A (en) | 2016-01-06 |
GB2478425A (en) | 2011-09-07 |
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