US20130281727A1 - Metal carbamates formed from diaminophenylmethane - Google Patents
Metal carbamates formed from diaminophenylmethane Download PDFInfo
- Publication number
- US20130281727A1 US20130281727A1 US13/920,166 US201313920166A US2013281727A1 US 20130281727 A1 US20130281727 A1 US 20130281727A1 US 201313920166 A US201313920166 A US 201313920166A US 2013281727 A1 US2013281727 A1 US 2013281727A1
- Authority
- US
- United States
- Prior art keywords
- formula
- heteroatoms
- atoms
- alkali metal
- diaminophenylmethane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C1=CC=C(CC2=CC=CC=C2)C=C1.CC(=O)N(C)C.CN(C)C(=O)[2*]O.I Chemical compound C1=CC=C(CC2=CC=CC=C2)C=C1.CC(=O)N(C)C.CN(C)C(=O)[2*]O.I 0.000 description 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Definitions
- the invention provides metal carbamates formed from diaminophenylmethane (MDA) and a process for preparing them.
- MDA diaminophenylmethane
- Lewis acids for example uranium salts (U.S. Pat. No. 3,763,217), aluminum turnings with iodine and Hg promoters (U.S. Pat. No. 4,550,188), zinc salts, iron salts, antimony salts and tin salts (U.S. Pat. Nos. 4,268,683, 4,268,684, EP 391473), are used as catalysts.
- a disadvantage for the industrial use of these processes are the sometimes low conversions, low selectivities or both.
- WO 2007/015852 describes the use of Lewis acidic heterogeneous catalysts for the urethanization of aromatic amines. This dispenses with a complicated removal of a homogeneous catalyst. The resulting conversions are too low for industrial scale applications and decrease together with the selectivity with increasing lifetime of the heterogeneous catalyst.
- urethanes can be prepared from aromatic amines using basic compounds, for example, alkali metal or alkaline earth metal alkoxides.
- DE 3202690 describes the preparation of aromatic urethanes by reaction of aniline and dialkyl carbonates in the presence of a small amount of a metal alkoxide as a catalyst.
- the conversions described in the examples are incomplete and the selectivities achieved are insufficient for an industrial application.
- N-arylcarbamates can be converted to isocyanates. Such processes are common knowledge. This procedure allows diisocyanates to be prepared by a phosgene-free route. Such processes are used to prepare aliphatic diisocyanates in particular.
- aromatic diisocyanates preparation by a phosgene-free process is difficult, since a series of side reactions proceed owing to the high reactivity of the aromatic compounds.
- aromatic diisocyanates which are industrially of great significance, were also preparable by phosgene-free processes.
- MDA diaminophenylmethane
- R 1 and R 2 are the same or different and are each an alkyl group having 1-18 carbon atoms and M is an alkali metal atom.
- alkyl groups having 2-7 carbon atoms which may be branched, unbranched or cyclic, especially branched or unbranched.
- R 1 and R 2 groups are identical.
- the invention further provides a process for preparing metal carbamates of the general formula (I) by reacting
- R 1 and R 2 are each as defined above and
- the alkyl chain R 1 and/or R 2 is modified with heteroatoms.
- the heteroatoms may be halogen atoms, preferably fluorine atoms and/or chlorine atoms, more preferably fluorine atoms.
- the heteroatoms are oxygen atoms. These are preferably present in the form of ether groups.
- R 1 and/or R 2 is preferably an ethyl, propyl, butyl, di-2-methylpropyl, di-2-methylpropyl, di-3-methylbutyl, di-n-pentyl, 2-methoxyethyl, 2-ethoxyethyl or a 2,2,2-trifluoroethyl group.
- R1 and R2 are more preferably identical. This has the advantage that, in the course of preparation of the inventive products (I) and in the course of any further processing to urethanes and conversion thereof to isocyanates, fewer products are in the process.
- the compounds of the general formula (I) are solid at room temperature and can be removed from the reaction solution without any problem and in high purity. If required, they can be purified in a further process step.
- the compounds of the general formula (I) are prepared, as described above, by reaction of components a), b) and c).
- the diaminophenylmethane (MDA) used may be any isomers in any mixing ratios. Preference is given to using 2,4′-diaminophenylmethane, 4,4′-diaminophenylmethane, 2,2′-diaminophenylmethane and higher homologs (polyaminopolyphenylmethanes) and isomer mixtures.
- the dialkyl carbonates b) are selected from the group comprising diethyl carbonate, di-n-propyl carbonate, di-n-butyl carbonate, di-2-methylpropyl carbonate, di-3-methylbutyl carbonate, di-n-pentyl carbonate, bis-2-methoxyethyl carbonate, bis-2-ethoxyethyl carbonate, bis-2,2,2-trifluoroethyl carbonate.
- the metal compound c) preferably comprises basic organic metal compounds, especially compounds of alkali metals. They may, for example, be compounds comprising nitrogen atoms, for example amides, such as sodium amide or compounds comprising silicon atoms and nitrogen atoms, for example lithium hexamethyldisilazide.
- the base more preferably comprises the alkoxides of alkali metals.
- the alkali metal M is preferably lithium, sodium or potassium.
- the alcohol radicals preferably corresponds to those of the alkyl carbonates of the general formula (II) used.
- the compounds of the general formula (I) are prepared preferably under standard pressure at temperatures between 100 and 150° C.
- the yield of the process is between 95-100%.
- the ratio of carbonate groups to amino groups is from 1:1 to 10:1, more preferably from 2:1 to 3:1.
- the metal compound c) is preferably used in a stoichiometric amount, more preferably in a molar ratio of 1:1, based on the amino groups, i.e. in a ratio of about one mole of base per amino group.
- inventive metal carbamates may, as described, be converted to pure MDU by reprotonation with water.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
- This application is a Divisional of U.S. application Ser. No. 12/918,931, filed Aug. 23, 2010; which is a 371 of PCT/EP09/53168, filed Mar. 18, 2009, and priority to European patent application 08152934.9, filed Mar. 18, 2008, is claimed, of which the entire content is incorporated herein by reference.
- The invention provides metal carbamates formed from diaminophenylmethane (MDA) and a process for preparing them.
- Carbamates and the preparation and use thereof are known.
- For the preparation of carbamates and urethanes, a series of processes is known.
- In these processes, for example, Lewis acids, for example uranium salts (U.S. Pat. No. 3,763,217), aluminum turnings with iodine and Hg promoters (U.S. Pat. No. 4,550,188), zinc salts, iron salts, antimony salts and tin salts (U.S. Pat. Nos. 4,268,683, 4,268,684, EP 391473), are used as catalysts. A disadvantage for the industrial use of these processes are the sometimes low conversions, low selectivities or both.
- High selectivities and yields are obtained, for example, in processes catalyzed with Lewis acids (Pb salts as catalysts), when a high excess of dialkyl carbonate (amine:carbonate 1:20) is used (WO 98/55451, WO 98/56758). The high excess of dialkyl carbonate leads to large recycle streams.
- In other cases, high yields of urethane can be achieved when the urea formed in the urethanization is redissociated thermally to the corresponding urethane in an additional reaction (EP 048371 (catalysts: lead salts, titanium salts, zinc salts and zirconium salts), EP 391473 (catalyst: Zn salts)). The redissociation requires an additional, energy-intensive step.
- A further disadvantage in the case of use of Lewis acids as homogeneous catalysts is the catalyst residues which remain in the product and can be removed only incompletely.
- WO 2007/015852 describes the use of Lewis acidic heterogeneous catalysts for the urethanization of aromatic amines. This dispenses with a complicated removal of a homogeneous catalyst. The resulting conversions are too low for industrial scale applications and decrease together with the selectivity with increasing lifetime of the heterogeneous catalyst.
- It is also known that urethanes can be prepared from aromatic amines using basic compounds, for example, alkali metal or alkaline earth metal alkoxides.
- DE 3202690 describes the preparation of aromatic urethanes by reaction of aniline and dialkyl carbonates in the presence of a small amount of a metal alkoxide as a catalyst. The conversions described in the examples are incomplete and the selectivities achieved are insufficient for an industrial application.
- Journal of Organic Chemistry, 2005, 70, 2219-2224 describes the reaction of aniline with a large excess of dimethyl carbonate (40-fold excess) in the presence of an excess of base such as sodium methoxide (NaOMe) or potassium tert-butoxide (KOtBu). With NaOMe, a selectivity of 67% after a reaction time of 210 min was obtained. With KOtBu, a selectivity after 1 min of 100% is described, which, however, declines to 60% through formation of the N-methylcarbanilate by-product with increasing reaction time. Conversions and isolated yields were not described.
- N-arylcarbamates can be converted to isocyanates. Such processes are common knowledge. This procedure allows diisocyanates to be prepared by a phosgene-free route. Such processes are used to prepare aliphatic diisocyanates in particular.
- In the case of aromatic diisocyanates, preparation by a phosgene-free process is difficult, since a series of side reactions proceed owing to the high reactivity of the aromatic compounds. However, it would be desirable if aromatic diisocyanates, which are industrially of great significance, were also preparable by phosgene-free processes.
- It was an object of the present invention to find a simple means of providing starting materials for the preparation of aromatic diisocyanates by a phosgene-free process, which can be prepared with a high selectivity, a high yield and with high purity.
- It has been found that, surprisingly, it is possible to isolate metal carbamates based on diaminophenylmethane (MDA) in pure form. After reaction with protic compounds, especially with alcohols or preferably with water, these can be converted to the corresponding diurethane (MDU) and, in a subsequent step, by thermal cleavage to MDI (methylene diphenyl diisocyanate).
- The invention accordingly provides metal carbamates of the general formula (I)
- where R1 and R2 are the same or different and are each an alkyl group having 1-18 carbon atoms and M is an alkali metal atom.
- Particular preference is given to alkyl groups having 2-7 carbon atoms, which may be branched, unbranched or cyclic, especially branched or unbranched.
- In a preferred embodiment of the invention the R1 and R2 groups are identical.
- The invention further provides a process for preparing metal carbamates of the general formula (I) by reacting
-
- a) diamino diphenylmethane with
- b) an alkyl carbonate of the general formula (II)
- where R1 and R2 are each as defined above and
-
- c) a metal compound of the general formula (III)
- M(R3)n
where - M is an alkali metal atom,
- R3 are the same as OR1 and OR2, or are an amide or an alkylsilazide and
- n is equal to 1.
- In one embodiment of the invention the alkyl chain R1 and/or R2 is modified with heteroatoms. The heteroatoms may be halogen atoms, preferably fluorine atoms and/or chlorine atoms, more preferably fluorine atoms. In another embodiment, the heteroatoms are oxygen atoms. These are preferably present in the form of ether groups.
- It has been found that the urethanes which have been prepared using diaklyl carbonates having heteroatoms in the alkyl group can be cleaved particularly readily to form isocyanates.
- R1 and/or R2 is preferably an ethyl, propyl, butyl, di-2-methylpropyl, di-2-methylpropyl, di-3-methylbutyl, di-n-pentyl, 2-methoxyethyl, 2-ethoxyethyl or a 2,2,2-trifluoroethyl group.
- R1 and R2 are more preferably identical. This has the advantage that, in the course of preparation of the inventive products (I) and in the course of any further processing to urethanes and conversion thereof to isocyanates, fewer products are in the process.
- The compounds of the general formula (I) are solid at room temperature and can be removed from the reaction solution without any problem and in high purity. If required, they can be purified in a further process step.
- The compounds of the general formula (I) are prepared, as described above, by reaction of components a), b) and c).
- The diaminophenylmethane (MDA) used may be any isomers in any mixing ratios. Preference is given to using 2,4′-diaminophenylmethane, 4,4′-diaminophenylmethane, 2,2′-diaminophenylmethane and higher homologs (polyaminopolyphenylmethanes) and isomer mixtures.
- In a preferred embodiment of the invention, the dialkyl carbonates b) are selected from the group comprising diethyl carbonate, di-n-propyl carbonate, di-n-butyl carbonate, di-2-methylpropyl carbonate, di-3-methylbutyl carbonate, di-n-pentyl carbonate, bis-2-methoxyethyl carbonate, bis-2-ethoxyethyl carbonate, bis-2,2,2-trifluoroethyl carbonate.
- The metal compound c) preferably comprises basic organic metal compounds, especially compounds of alkali metals. They may, for example, be compounds comprising nitrogen atoms, for example amides, such as sodium amide or compounds comprising silicon atoms and nitrogen atoms, for example lithium hexamethyldisilazide.
- The base more preferably comprises the alkoxides of alkali metals. The alkali metal M is preferably lithium, sodium or potassium. The alcohol radicals preferably corresponds to those of the alkyl carbonates of the general formula (II) used.
- The compounds of the general formula (I) are prepared preferably under standard pressure at temperatures between 100 and 150° C. The yield of the process is between 95-100%.
- In the reaction, the ratio of carbonate groups to amino groups is from 1:1 to 10:1, more preferably from 2:1 to 3:1.
- The metal compound c) is preferably used in a stoichiometric amount, more preferably in a molar ratio of 1:1, based on the amino groups, i.e. in a ratio of about one mole of base per amino group.
- The inventive metal carbamates may, as described, be converted to pure MDU by reprotonation with water.
- The fact that a simple process would be able to prepare pure metal carbamates and the object of the invention would thus be achieved was not foreseeable to the person skilled in the art.
- It was also unnecessary to work with a high excess of component b). In spite of the different reactivity of the two amino groups of the MDA, there was homogeneous conversion of the two amino groups.
Claims (19)
1. (canceled)
3. The process of claim 2 , wherein, in formula (I), the alkyl groups R1 and R2 each comprise 2-18 carbon atoms in the chain.
4. The process of claim 2 , wherein, in formula (I), the alkyl groups R1 and R2 each comprise 2-7 carbon atoms in the chain.
5. The process of claim 2 , wherein, in formula (I), the alkyl groups R1 and R2 are each independently an ethyl, propyl, butyl, 2-methylpropyl, 3-methylbutyl, n-pentyl, 2-methoxyethyl, 2-ethoxyethyl, or a 2,2,2-trifluoroethyl group.
6. The process of claim 2 , wherein, in formula (I), the alkyl groups R1 and R2 comprise heteroatoms.
7. The process of claim 6 , wherein the heteroatoms are halogen atoms.
8. The process of claim 6 , wherein the heteroatoms are fluorine atoms.
9. The process of claim 6 , wherein the heteroatoms are chlorine atoms.
10. The process of claim 6 , wherein the heteroatoms are oxygen atoms.
11. The process of claim 6 , wherein the heteroatoms are oxygen atoms present in the form of ether groups.
12. The process of claim 2 , wherein, in formula (I), the alkali metal ion is lithium.
13. The process of claim 2 , wherein, in formula (I), the alkali metal ion is sodium.
14. The process of claim 2 , wherein, in formula (I), the alkali metal ion is potassium.
15. The process of claim 2 , wherein, in formula (I), wherein R1 and R2 are identical.
16. The process of claim 3 , wherein, in formula (I), R1 and R2 are identical.
17. The process of claim 4 , wherein, in formula (I), R1 and R2 are identical.
18. The process of claim 5 , wherein, in formula (I), R1 and R2 are identical.
19. The process of claim 6 , wherein, in formula (I), R1 and R2 are identical.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/920,166 US8846971B2 (en) | 2008-03-18 | 2013-06-18 | Metal carbamates formed from diaminophenylmethane |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08152934 | 2008-03-18 | ||
EP08152934 | 2008-03-18 | ||
EP08152934.9 | 2008-03-18 | ||
PCT/EP2009/053168 WO2009115537A1 (en) | 2008-03-18 | 2009-03-18 | Metal carbamates formed from diaminophenylmethane |
US91893110A | 2010-08-23 | 2010-08-23 | |
US13/920,166 US8846971B2 (en) | 2008-03-18 | 2013-06-18 | Metal carbamates formed from diaminophenylmethane |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/053168 Division WO2009115537A1 (en) | 2008-03-18 | 2009-03-18 | Metal carbamates formed from diaminophenylmethane |
US12/918,931 Division US8519174B2 (en) | 2008-03-18 | 2009-03-18 | Metal carbamates formed from diaminophenylmethane |
US91893110A Division | 2008-03-18 | 2010-08-23 |
Publications (2)
Publication Number | Publication Date |
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US20130281727A1 true US20130281727A1 (en) | 2013-10-24 |
US8846971B2 US8846971B2 (en) | 2014-09-30 |
Family
ID=40589683
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US12/918,931 Expired - Fee Related US8519174B2 (en) | 2008-03-18 | 2009-03-18 | Metal carbamates formed from diaminophenylmethane |
US13/920,166 Expired - Fee Related US8846971B2 (en) | 2008-03-18 | 2013-06-18 | Metal carbamates formed from diaminophenylmethane |
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Application Number | Title | Priority Date | Filing Date |
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US12/918,931 Expired - Fee Related US8519174B2 (en) | 2008-03-18 | 2009-03-18 | Metal carbamates formed from diaminophenylmethane |
Country Status (9)
Country | Link |
---|---|
US (2) | US8519174B2 (en) |
EP (1) | EP2265572B1 (en) |
JP (1) | JP5529110B2 (en) |
KR (1) | KR20110003470A (en) |
CN (1) | CN101977893B (en) |
BR (1) | BRPI0909277A2 (en) |
ES (1) | ES2387187T3 (en) |
PL (1) | PL2265572T3 (en) |
WO (1) | WO2009115537A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5709740B2 (en) * | 2008-03-18 | 2015-04-30 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | Process for producing urethanes comprising mono- and difunctional aromatic amines |
US8871965B2 (en) | 2009-10-21 | 2014-10-28 | Basf Se | Method for producing urethanes |
ES2502537T3 (en) | 2009-10-27 | 2014-10-03 | Basf Se | Procedure for the coupled production of di- and / or polyisocyanates and glycols |
US8680323B2 (en) * | 2010-01-19 | 2014-03-25 | Basf Se | Process for preparing isocyanates by thermal dissociation of carbamates |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US3671486A (en) * | 1967-08-18 | 1972-06-20 | Ici Ltd | Filled fusible aromatic prepolymer composition |
US3763217A (en) | 1970-12-03 | 1973-10-02 | Halcon International Inc | Preparation of carbamates |
US4268683A (en) | 1980-02-21 | 1981-05-19 | The Dow Chemical Company | Preparation of carbamates from aromatic amines and organic carbonates |
US4268684A (en) | 1980-02-25 | 1981-05-19 | The Dow Chemical Company | Preparation of carbamates from aromatic amines and organic carbonates |
DE3035354A1 (en) | 1980-09-19 | 1982-04-29 | Bayer Ag, 5090 Leverkusen | METHOD FOR THE PRODUCTION OF N, O-DISUBSTITUTED URETHANES AND THE USE THEREOF AS THE STARTING MATERIAL FOR THE PRODUCTION OF ORGANIC ISOCYANATES |
IT1141960B (en) * | 1981-01-28 | 1986-10-08 | Anic Spa | PROCEDURE FOR THE PREPARATION OF AROMATIC URETANS |
US4525305A (en) * | 1982-10-25 | 1985-06-25 | Minnesota Mining And Manufacturing Company | Leather with fluorochemical finish |
US4550188A (en) | 1984-06-27 | 1985-10-29 | The Dow Chemical Company | Preparation of carbamates |
DE3627257A1 (en) * | 1986-08-12 | 1988-02-18 | Bayer Ag | 5-Hydroxymethylpropyleneureas and a process for their preparation |
IT1229144B (en) | 1989-04-07 | 1991-07-22 | Enichem Sintesi | PROCEDURE FOR THE PRODUCTION OF CARBAMATES. |
JPH06247836A (en) * | 1993-02-22 | 1994-09-06 | Pola Chem Ind Inc | Basic cosmetic |
WO1998055451A1 (en) | 1997-06-05 | 1998-12-10 | Huntsman Ici Chemicals Llc | Method for the preparation of carbamates |
WO1998056758A1 (en) | 1997-06-09 | 1998-12-17 | Huntsman Ici Chemicals Llc | Process for the production of organic isocyanates |
TW565582B (en) * | 2001-04-13 | 2003-12-11 | Kaneka Corp | Diamine, acid dianhydride, and reactive group containing polyimide composition prepared therefrom and preparing them |
US20080227999A1 (en) | 2005-07-20 | 2008-09-18 | Molzahn David C | Heterogeneous Supported Catalytic Carbamate Process |
JP5514797B2 (en) | 2008-03-18 | 2014-06-04 | ビーエーエスエフ ソシエタス・ヨーロピア | Metal carbamates formed from tolylenediamine |
-
2009
- 2009-03-18 WO PCT/EP2009/053168 patent/WO2009115537A1/en active Application Filing
- 2009-03-18 CN CN200980109588.1A patent/CN101977893B/en not_active Expired - Fee Related
- 2009-03-18 ES ES09721321T patent/ES2387187T3/en active Active
- 2009-03-18 PL PL09721321T patent/PL2265572T3/en unknown
- 2009-03-18 US US12/918,931 patent/US8519174B2/en not_active Expired - Fee Related
- 2009-03-18 EP EP09721321A patent/EP2265572B1/en active Active
- 2009-03-18 KR KR1020107020070A patent/KR20110003470A/en active IP Right Grant
- 2009-03-18 JP JP2011500207A patent/JP5529110B2/en not_active Expired - Fee Related
- 2009-03-18 BR BRPI0909277A patent/BRPI0909277A2/en active Search and Examination
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2013
- 2013-06-18 US US13/920,166 patent/US8846971B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20110003470A (en) | 2011-01-12 |
US8519174B2 (en) | 2013-08-27 |
US8846971B2 (en) | 2014-09-30 |
CN101977893A (en) | 2011-02-16 |
ES2387187T3 (en) | 2012-09-17 |
JP2011515365A (en) | 2011-05-19 |
PL2265572T3 (en) | 2012-12-31 |
US20110015424A1 (en) | 2011-01-20 |
JP5529110B2 (en) | 2014-06-25 |
EP2265572B1 (en) | 2012-07-18 |
BRPI0909277A2 (en) | 2015-10-06 |
WO2009115537A8 (en) | 2010-02-04 |
EP2265572A1 (en) | 2010-12-29 |
CN101977893B (en) | 2014-07-16 |
WO2009115537A1 (en) | 2009-09-24 |
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