US20130072497A1 - N- substituted piperazines - Google Patents

N- substituted piperazines Download PDF

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Publication number
US20130072497A1
US20130072497A1 US13/676,381 US201213676381A US2013072497A1 US 20130072497 A1 US20130072497 A1 US 20130072497A1 US 201213676381 A US201213676381 A US 201213676381A US 2013072497 A1 US2013072497 A1 US 2013072497A1
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Prior art keywords
insecticides
compound
alkyl
compounds
refers
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US13/676,381
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Beth Lorsbach
James M. Ruiz
Thomas C. Sparks
Michael T. Sullenberger
Irene Mae Morrison
Jeffery D. Webster
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Corteva Agriscience LLC
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Dow AgroSciences LLC
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Definitions

  • the present invention relates to compounds of Formula (I)
  • X and Y are each independently selected from the group consisting of a direct bond, alkyl, carbonyl, carbonylalkyl, carbonylalkylether, carboxylalkyl, alkylcarbonyl, alkylcarboxyl, and alkylether;
  • aryl optionally substituted with cyano, alkoxy, halogen, alkylhalo, alkoxyhalo, carboxylalkyl, carbonylalkyl, benzyloxy, nitro, benzoyl, phenyl, carboxamido, or heteroaryl;
  • heteroaryl optionally substituted with aryl, heteroaryl, alkyl, halogen, alkylhalo, alkoxy, cycloalkyl or cyano;
  • heterocyclic ring optionally substituted with alkyl
  • the present invention also relates to insecticidal or fungicidal compositions thereof and methods of use.
  • the present invention relates to the compounds of Formula (I), compositions thereof and their use as insecticides and fungicides, in accordance with the definitions herein.
  • R is an alkyl group
  • X refers to a halogen atom
  • the symbol ‘*’ denotes the point of attachment.
  • alkoxy refers to an alkyl group, attached through an oxygen atom, e.g. *—OR.
  • alkoxyhalo refers to an alkoxy group which is substituted with one or more halogens (*—O—R—X n ).
  • alkyl (including derivative terms such as alkoxy) as used herein includes straight and branched chains containing from 1 to 6 carbon atoms. Thus, typical alkyl groups are methyl, ethyl, 1-methylethyl, propyl, and 1,1-dimethylethyl, and the like.
  • alkylcarbonyl refers to an alkyl group attached to a carbonyl (*—R—C(O)—).
  • alkylcarboxyl refers to an alkyl group attached to a carboxyl group (*—R—C(O)—O—).
  • alkylether refers to an alkyl group attached to an oxygen (*—R—O—).
  • alkylhalo refers to an alkyl group which is substituted with one or more halogens (*—R—X n ).
  • aryl refers to a mono or bicyclic aromatic ring, such as phenyl or naphthalene.
  • benzodioxane refers to a 10 membered, fused, bicyclic aromatic ring containing two oxygen atoms in the para position of the second, 6-membered, non-aromatic ring, i.e. a benzene ring fused to a dioxane ring.
  • benzodioxole refers to a 9 membered, fused, bicyclic aromatic ring containing two non adjacent oxygen atoms in the second, five-membered, non-aromatic ring, i.e. a benzene ring fused to a dioxole ring.
  • benzothiophene refers to a 9 membered, fused, bicyclic aromatic ring containing one sulfur atom, i.e. a benzene ring fused to a thiophene ring.
  • benzoyl refers to a carbonyl group attached to a phenyl group (*—C(O)-phenyl).
  • benzyloxy refers to a benzyl group attached to an oxygen atom (*—O—CH 2 -phenyl).
  • carbonyl refers to a carbon atom double bonded to an oxygen atom (*—C(O)—).
  • carbonylalkyl refers to a carbonyl group attached to an alkyl group (*—C(O)—R—).
  • carbonylalkylether refers to a carbonyl group attached to an alkylether group (*—C(O)—R—O—).
  • carboxylate refers to a carbonyl group attached to an amino group (*—C(O)—NH 2 ).
  • carboxylalkyl refers to a carboxyl group attached to an alkyl group (*—C(O)—O—R—).
  • cyano refers to a carbon atom triple bonded to a nitrogen atom (*—C ⁇ N).
  • cycloalkyl refers to a saturated C3-C6 membered ring, such as cyclobutane, cyclopropane, cyclohexane and the like.
  • halogen refers to the atoms fluorine, chlorine, bromine, and iodine.
  • heteroaryl refers to a 5 or 6 membered unsaturated ring containing one, two or three heteroatoms, preferably one or two heteroatoms independently selected from oxygen, nitrogen and sulfur; or to a bicyclic unsaturated ring system containing up to 11 atoms including one, two or three heteroatoms selected from oxygen, nitrogen and sulfur.
  • heteroaryl rings include, but are not limited to, 2-, 3- or 4-pyridine, pyrazine, pyrazole, 2-, 4-, or 5-pyrimidine, 2- or 3-thiophene, 2- or 3-furan, oxazole, quinoline, benzofuran, benzopyronye, benzothiophene, thiophenepyrazoline, thiadiazole, benzodioxane, benzodioxole, indole, pyridazine, triazole, imidazole, pyrrole, isoxazole, thiazole, isothiazole, oxadiazole, thiadiazole isoquinoline and the like.
  • the ring may be attached at any position so long as the laws of chemical valency and stereochemistry are observed.
  • heterocyclic refers to a 3 to 5 membered, saturated ring containing 1-3 heteroatoms selected from oxygen, nitrogen or sulfur; such as oxirane, pyrrolidine, morpholine rings and the like.
  • the ring may be attached at any position so long as the laws of chemical valency and stereochemistry are observed.
  • nitro refers to a nitrogen atom bonded to two oxygen atoms, (*—NO 2 ).
  • oxazole refers to a 5 membered, aromatic ring containing one oxygen atom and one nitrogen atom, non-adjacent to each other, i.e. an oxazole ring.
  • oxirane refers to a 3 membered ring containing oxygen and carbon, i.e.
  • pyrazine refers to a 6 membered, aromatic ring containing 2 nitrogen atoms, wherein the N's are in the para position.
  • pyrazole refers to a 5 membered, aromatic ring containing 2 nitrogen atoms, wherein the N's are adjacent to one another.
  • thiadiazole refers to a 5 membered, aromatic ring containing two nitrogen atoms and a sulfur atom.
  • thiophenepyrazoline refers to a 8 membered, fused, bicyclic aromatic ring containing one sulfur atom, and two nitrogen atoms, wherein the sulfur atom is part of a thiophene ring and the nitrogen atoms are part of a pyrazoline ring fused therewith.
  • X and Y are each independently selected from the group consisting of a direct bond, alkyl, and carbonyl;
  • aryl optionally substituted with cyano, alkoxy, halogen, alkylhalo, alkoxyhalo, carboxylalkyl, carbonylalkyl, benzyloxy, nitro, benzoyl, phenyl, carboxamido, or heteroaryl;
  • heteroaryl optionally substituted with aryl, heteroaryl, alkyl, halogen, alkylhalo, alkoxy, cycloalkyl or cyano.
  • the compounds of the present invention can exist as one or more stereoisomers.
  • the various stereoisomers include geometric isomers, diastereomers and enantiomers.
  • the compounds of the present invention include racemic mixtures, individual stereoisomers and optically active mixtures. It will be appreciated by those skilled in the art that one stereoisomer may be more active than the others.
  • Individual stereoisomers and optically active mixtures may be obtained by selective synthetic procedures, by conventional synthetic procedures using resolved starting materials or by conventional resolution procedures.
  • the compounds of the present invention can be prepared by known methods in the art as outlined in the examples of the present specification.
  • compositions comprising a compound of Formula (I) and a phytologically-acceptable inert carrier.
  • the compositions are typically either concentrated formulations which are dispersed in water for application, or are dust or granular formulations which are applied without further treatment.
  • the compositions are prepared according to procedures and formulae which are conventional in the agricultural chemical art, but which are novel and important because of the presence therein of the compounds of this invention. Some description of the formulation of the compositions will be given, however, to assure that agricultural chemists can readily prepare any desired composition.
  • the dispersions in which the compounds are applied are most often aqueous suspensions or emulsions prepared from concentrated formulations of the compounds.
  • Such water-soluble, water-suspendable or emulsifiable formulations are either solids, usually known as wettable powders, or liquids usually known as emulsifiable concentrates or aqueous suspensions.
  • Wettable powders which may be compacted to form water dispersible granules, comprise an intimate mixture of the active compound, an inert carrier, and surfactants.
  • the concentration of the active compound is usually from about 10% to about 90% by weight.
  • the inert carrier is usually chosen from among the attapulgite clays, the montmorillonite clays, the diatomaceous earths, or the purified silicates.
  • Effective surfactants comprising from about 0.5% to about 10% of the wettable powder, are found among the sulfonated lignins, the condensed naphthalenesulfonates, the naphthalenesulfonates, the alkylbenzenesulfonates, the alkyl sulfates, and nonionic surfactants such as ethylene oxide adducts of alkyl phenols.
  • Emulsifiable concentrates of the compounds comprise a convenient concentration of a compound, such as from about 50 to about 500 grams per liter of liquid, equivalent to about 10% to about 50%, dissolved in an inert carrier which is either a water miscible solvent or a mixture of water-immiscible organic solvent and emulsifiers.
  • Useful organic solvents include aromatics, especially the xylenes, and the petroleum fractions, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha.
  • Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such as 2-ethoxyethanol.
  • Suitable emulsifiers for emulsifiable concentrates are chosen from conventional nonionic surfactants, such as those discussed above.
  • Aqueous suspensions comprise suspensions of water-insoluble compounds of this invention, dispersed in an aqueous vehicle at a concentration in the range from about 5% to about 50% by weight.
  • Suspensions are prepared by finely grinding the compound, and vigorously mixing it into a vehicle comprised of water and surfactants chosen from the same types discussed above.
  • Inert ingredients such as inorganic salts and synthetic or natural gums, may also be added, to increase the density and viscosity of the aqueous vehicle. It is often most effective to grind and mix the compound at the same time by preparing the aqueous mixture, and homogenizing it in an implement such as a sand mill, ball mill, or piston-type homogenizer.
  • the compounds may also be applied as granular compositions, which are particularly useful for applications to the soil.
  • Granular compositions usually contain from about 0.5% to about 10% by weight of the compound, dispersed in an inert carrier which consists entirely or in large part of clay or a similar inexpensive substance.
  • Such compositions are usually prepared by dissolving the compound in a suitable solvent and applying it to a granular carrier which has been pre-formed to the appropriate particle size, in the range of from about 0.5 to 3 mm.
  • Such compositions may also be formulated by making a dough or paste of the carrier and compound and crushing and drying to obtain the desired granular particle size.
  • Dusts containing the compounds are prepared simply by intimately mixing the compound in powdered form with a suitable dusty agricultural carrier, such as kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1% to about 10% of the compound.
  • Insecticides, acaricides and fungicides are generally applied in the form of a dispersion of the active ingredient in a liquid carrier. It is conventional to refer to application rates in terms of the concentration of active ingredient in the carrier. The most widely used carrier is water.
  • the compounds of the present invention can also be applied in the form of an aerosol composition.
  • the active compound is dissolved or dispersed in an inert carrier, which is a pressure-generating propellant mixture.
  • the aerosol composition is packaged in a container from which the mixture is dispensed through an atomizing valve.
  • Propellant mixtures comprise either low-boiling halocarbons, which may be mixed with organic solvents, or aqueous suspensions pressurized with inert gases or gaseous hydrocarbons.
  • the formulations may additionally contain adjuvant surfactants to enhance deposition, wetting and penetration of the compounds onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix.
  • the amount of adjuvant surfactant will typically vary from 0.01 to 1.0% by volume, based on a spray-volume of water, preferably 0.05 to 0.5 volume %.
  • Suitable adjuvant surfactants include, but are not limited to ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts of the esters or sulphosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines and blends of surfactants with mineral or vegetable oils.
  • Another aspect of the present invention relates to a method for inhibiting an insect which comprises applying to a locus of the insect an insect-inhibiting amount of a compound of Formula (I).
  • insects are a term used herein to refer to the environment in which the insects live or where their eggs are present, including the air surrounding them, the food they eat, or objects which they contact.
  • insects which eat or contact edible or ornamental plants can be controlled by applying the active compound to plant parts such as the seed, seedling, or cutting which is planted, the leaves, stems, fruits, grain, or roots, or to the soil in which the roots are growing.
  • the compounds might also be useful to protect textiles, paper, stored grain, seeds, domesticated animals, buildings or human beings by applying an active compound to or near such objects.
  • the term “inhibiting an insect” refers to a decrease in the numbers of living insects, or a decrease in the number of viable insect eggs.
  • inactivating amount is used to describe the amount, which is sufficient to cause a measurable reduction in the treated insect population. Generally an amount in the range from about 1 to about 1000 ppm by weight active compound is used.
  • the actual amount of compound to be applied to loci of insects and mites is not critical and can readily be determined by those skilled in the art in view of the examples above. In general, concentrations from 10 ppm to 5000 ppm by weight of compound are expected to provide good control. With many of the compounds, concentrations from 100 to 1500 ppm will suffice.
  • the locus to which a compound is applied can be any locus inhabited by an insect or mite, for example, vegetable crops, fruit and nut trees, grape vines, ornamental plants, domesticated animals, the interior or exterior surfaces of buildings, and the soil around buildings.
  • Another embodiment of the present invention is a method for the control or prevention of fungal attack.
  • This method comprises applying to the soil, plant, roots, foliage, seed or locus of the fungus, or to a locus in which the infestation is to be prevented (for example applying to cereal or grape plants), a fungicidal effective amount of one or more of the compounds.
  • the compounds are suitable for treatment of various plants at fungicidal levels, while exhibiting low phytotoxicity.
  • the compounds are useful both in a protectant and/or an eradicant fashion.
  • the compounds have been found to have significant fungicidal effect particularly for agricultural use. Many of the compounds are particularly effective for use with agricultural crops and horticultural plants. It will be understood by those in the art that the efficacy of the compound for the foregoing fungi establishes the general utility of the compounds as fungicides.
  • the compounds have broad ranges of efficacy as fungicides.
  • the exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the fungal species to be controlled, and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally effective at similar concentrations or against the same fungal species.
  • the compounds are effective in use with plants in a disease-inhibiting and phytologically acceptable amount.
  • disease inhibiting and phytologically acceptable amount refers to an amount of a compound that kills or inhibits the plant disease for which control is desired, but is not significantly toxic to the plant. This amount will generally be from about 0.1 to about 1000 ppm (parts per million), with 1 to 500 ppm being preferred.
  • concentration of compound required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like.
  • a suitable application rate is typically in the range from about 0.10 to about 4 pounds/acre (about 0.01 to 0.45 grams per square meter, g/m 2 ).
  • the compounds of the present invention are often applied in conjunction with one or more other insecticides or fungicides to obtain control of a wider variety of pests and diseases.
  • additional pesticidal compounds may be fungicides, insecticides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present invention in the medium selected for application, and not antagonistic to the activity of the present compounds.
  • the other pesticidal compound is employed as a supplemental toxicant for the same or for a different pesticidal use.
  • the compounds of Formula I, and the pesticidal compound in the combination can generally be present in a weight ratio of from 1:100 to 100:1.
  • the presently claimed compounds can be formulated with the other insecticides or fungicides, tank mixed with the other insecticides or fungicides, or applied sequentially with the other insecticides or fungicides.
  • the compounds of the present invention may be synthesized by methods that are individually known to those skilled in the art.
  • step a of scheme A, alcohol 1 is treated with methan sulfonyl chloride and triethylamine (Et 3 N) at 0° C. to yield mesylate 2, which undergoes a nucleophilic displacement with piperazine in step b, to deliver compound 4.
  • the preferred solvent for the nucleophilic displacement is acetonitrile (CH 3 CN) and elevated temperatures are required to drive the reaction to completion.
  • Commercial mono-substituted piperazines were used directly in schemes B and C when available.
  • a substituted piperazine, 4 is reacted with an acid chloride 5 to yield the appropriately acyl piperazine 6.
  • the acylation is performed under basic conditions to neutralize the hydrochloric acid (HCl) formed during the reaction; examples of typical bases are diispropylamine (DIEA) and Et 3 N.
  • a substituted piperazine, 4 is reacted with chloro derivative 7 (note bromides can also be used) and heated at 80° C. in dimethylformamide (DMF) to give the appropriately substituted piperazine 8.
  • the reaction is performed under basic conditions to neutralize the HCl formed during the reaction; examples of typical bases are DIEA and Et 3 N.
  • t-butylcarbamate (BOC) protected piperazine can be utilized as illustrated in schemes D and E.
  • BOC protected piperazine is N-acylated with an acid chloride utilizing similar reactions previously described to yield compound 10.
  • the BOC group is removed with trifluoroacetic acid (TFA) in methylene chloride (CH 2 Cl 2 ) and the free base 11, is N-alkylated, again utilizing reaction conditions described earlier, to yield derivatives of 6.
  • TFA trifluoroacetic acid
  • reaction mixture was heated at 60° C. for 12 h.
  • the reaction mixture was cooled and extracted with ethyl acetate (EtOAc).
  • EtOAc ethyl acetate
  • the combined organic layers were washed with brine, dried over anhydrous Na 2 SO 4 and evaporated.
  • the crude residue was chromatographed on silica (20% EtOAc/Hexanes) and the product fractions were collected and evaporated to an amber solid (186 mg, 51%).
  • mosquito Aedes aegypti
  • beet armyworm Spodoptera exigua
  • fruit fly Drosophila melanogaster
  • cotton aphid Aphis gossypi
  • Newly hatched mosquito larvae about 50 larvae/well) in 96-well microtiter plates in 230 ul of water containing powdered liver/yeast extract (1 gr/100 ml) were treated with 20 ppm solution of the test compound. Following treatment the plates were covered with a lid and mortality was determined three days after treatment.
  • Beet armyworm eggs (about 5 per well) were placed on artificial diet (in a 96-well microtiter plate) treated with a 4000 ppm solution of a test compound in combination with piperonyl butoxide (in approximate ratio of 1:4). After infestation, the plates were covered with a lid and mortality was determined seven days following treatment. Five-day old fruit fly adults (about 5/well) were placed in deep-well microtiter plates containing 250 ul/well of a 2% agar-10% sucrose mixture that had been treated with a 4000 ppm solution of a test compound. Following infestation, the plates were covered with a lid and mortality was determined three days after treatment. Treatments for the mosquito and armyworm were replicated six times each, that of the fruit fly three times each.
  • the leaves were inoculated with an aqueous spore suspension of Leptosphaeria nodorum and the plants were kept in high humidity (one day in a dark dew chamber followed by four to seven days in a lighted dew chamber) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse until disease developed on untreated control plants.
  • LEPTNO refers to in vitro control one day protectant at 25 ppm on wheat glume blotch
  • SEPTTR refers to in vitro control one day protectant at 25 ppm on wheat leaf blotch

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Abstract

Novel N-alkyl substituted piperazines have been discovered, which are useful as insecticides or fungicides. Such compounds are of Formula (I)
Figure US20130072497A1-20130321-C00001
    • wherein X, Y, R1 and R2 are as defined herein.

Description

  • This application claims the benefit of U.S. Provisional Application No. 60/695,364, filed on Jun. 30, 2005, the entire contents of which is hereby incorporated by reference. Additionally, this application claims the benefit of U.S. Non-provisional application Ser. No. 11/479,772, filed 30 Jun. 2006, the entire contents of which is hereby incorporated by reference. Additionally, this application claims the benefit of U.S. Non-provisional application Ser. No. 12/787,440, filed 26 Jun. 2010, the entire contents of which is hereby incorporated by reference. The present invention relates to novel N-alkyl substituted piperazines and their use as fungicides and insecticides.
    • BACKGROUND OF THE INVENTION
  • Various piperazine derivatives have been disclosed in references such as WO 2004/060865, WO 97/26252, WO 01/46166, JP8-26995, JP63-141966, U.S. 2003/0044845, U.S. Pat. No. 6,011,035 and U.S. Pat. No. 6,387,897. However, these references do not disclose the piperazine derivatives of the present invention.
  • Additionally, there continues to be a need for additional insecticidal and fungicidal compounds, due to the continual development of resistance to the insecticides and fungicides currently used in the field. For example, there are at least 400 species of arthropods which are resistant to one or more insecticides. Therefore, the need continues to develop new insecticides and fungicides, and particularly for compounds that have new or atypical modes of action.
    • SUMMARY OF THE INVENTION
  • The present invention relates to compounds of Formula (I)
  • Figure US20130072497A1-20130321-C00002
  • wherein
  • X and Y are each independently selected from the group consisting of a direct bond, alkyl, carbonyl, carbonylalkyl, carbonylalkylether, carboxylalkyl, alkylcarbonyl, alkylcarboxyl, and alkylether;
      • with the proviso that both X and Y cannot be a direct bond; and when either X or Y is a direct bond, then the R1 or R2 associated with that bond is not phenyl or optionally substituted phenyl; and
        R1 and R2 are each independently selected from the group consisting of:
  • alkyl;
  • aryl, optionally substituted with cyano, alkoxy, halogen, alkylhalo, alkoxyhalo, carboxylalkyl, carbonylalkyl, benzyloxy, nitro, benzoyl, phenyl, carboxamido, or heteroaryl;
  • heteroaryl, optionally substituted with aryl, heteroaryl, alkyl, halogen, alkylhalo, alkoxy, cycloalkyl or cyano;
  • cycloalkyl, optionally substituted with alkyl or halogen; and
  • a heterocyclic ring, optionally substituted with alkyl.
  • The present invention also relates to insecticidal or fungicidal compositions thereof and methods of use.
    • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention relates to the compounds of Formula (I), compositions thereof and their use as insecticides and fungicides, in accordance with the definitions herein. In relation to the definitions hereafter, R is an alkyl group; X refers to a halogen atom, and the symbol ‘*’ denotes the point of attachment.
  • The term “alkoxy” refers to an alkyl group, attached through an oxygen atom, e.g. *—OR.
  • The term “alkoxyhalo” refers to an alkoxy group which is substituted with one or more halogens (*—O—R—Xn).
  • The term “alkyl” (including derivative terms such as alkoxy) as used herein includes straight and branched chains containing from 1 to 6 carbon atoms. Thus, typical alkyl groups are methyl, ethyl, 1-methylethyl, propyl, and 1,1-dimethylethyl, and the like.
  • The term “alkylcarbonyl” refers to an alkyl group attached to a carbonyl (*—R—C(O)—).
  • The term “alkylcarboxyl” refers to an alkyl group attached to a carboxyl group (*—R—C(O)—O—).
  • The term “alkylether” refers to an alkyl group attached to an oxygen (*—R—O—).
  • The term “alkylhalo” refers to an alkyl group which is substituted with one or more halogens (*—R—Xn).
  • The term “aryl” refers to a mono or bicyclic aromatic ring, such as phenyl or naphthalene.
  • The term “benzodioxane” refers to a 10 membered, fused, bicyclic aromatic ring containing two oxygen atoms in the para position of the second, 6-membered, non-aromatic ring, i.e. a benzene ring fused to a dioxane ring.
  • The term “benzodioxole” refers to a 9 membered, fused, bicyclic aromatic ring containing two non adjacent oxygen atoms in the second, five-membered, non-aromatic ring, i.e. a benzene ring fused to a dioxole ring.
  • The term “benzothiophene” refers to a 9 membered, fused, bicyclic aromatic ring containing one sulfur atom, i.e. a benzene ring fused to a thiophene ring.
  • The term “benzoyl” refers to a carbonyl group attached to a phenyl group (*—C(O)-phenyl).
  • The term “benzyloxy” refers to a benzyl group attached to an oxygen atom (*—O—CH2-phenyl).
  • The term “carbonyl” refers to a carbon atom double bonded to an oxygen atom (*—C(O)—).
  • The term “carbonylalkyl” refers to a carbonyl group attached to an alkyl group (*—C(O)—R—).
  • The term “carbonylalkylether” refers to a carbonyl group attached to an alkylether group (*—C(O)—R—O—).
  • The term “carboxamido” refers to a carbonyl group attached to an amino group (*—C(O)—NH2).
  • The term “carboxylalkyl” refers to a carboxyl group attached to an alkyl group (*—C(O)—O—R—).
  • The term “cyano” refers to a carbon atom triple bonded to a nitrogen atom (*—C≡N).
  • The term “cycloalkyl” refers to a saturated C3-C6 membered ring, such as cyclobutane, cyclopropane, cyclohexane and the like.
  • The term “halogen” or “halo” refers to the atoms fluorine, chlorine, bromine, and iodine.
  • The term “heteroaryl” refers to a 5 or 6 membered unsaturated ring containing one, two or three heteroatoms, preferably one or two heteroatoms independently selected from oxygen, nitrogen and sulfur; or to a bicyclic unsaturated ring system containing up to 11 atoms including one, two or three heteroatoms selected from oxygen, nitrogen and sulfur. Examples of heteroaryl rings include, but are not limited to, 2-, 3- or 4-pyridine, pyrazine, pyrazole, 2-, 4-, or 5-pyrimidine, 2- or 3-thiophene, 2- or 3-furan, oxazole, quinoline, benzofuran, benzopyronye, benzothiophene, thiophenepyrazoline, thiadiazole, benzodioxane, benzodioxole, indole, pyridazine, triazole, imidazole, pyrrole, isoxazole, thiazole, isothiazole, oxadiazole, thiadiazole isoquinoline and the like. The ring may be attached at any position so long as the laws of chemical valency and stereochemistry are observed.
  • The term “heterocyclic” refers to a 3 to 5 membered, saturated ring containing 1-3 heteroatoms selected from oxygen, nitrogen or sulfur; such as oxirane, pyrrolidine, morpholine rings and the like. The ring may be attached at any position so long as the laws of chemical valency and stereochemistry are observed.
  • The term “nitro” refers to a nitrogen atom bonded to two oxygen atoms, (*—NO2).
  • The term “oxazole” refers to a 5 membered, aromatic ring containing one oxygen atom and one nitrogen atom, non-adjacent to each other, i.e. an oxazole ring.
  • The term “oxirane” refers to a 3 membered ring containing oxygen and carbon, i.e.
  • Figure US20130072497A1-20130321-C00003
  • The term “pyrazine” refers to a 6 membered, aromatic ring containing 2 nitrogen atoms, wherein the N's are in the para position.
  • The term “pyrazole” refers to a 5 membered, aromatic ring containing 2 nitrogen atoms, wherein the N's are adjacent to one another.
  • The term “thiadiazole” refers to a 5 membered, aromatic ring containing two nitrogen atoms and a sulfur atom.
  • The term “thiophenepyrazoline” refers to a 8 membered, fused, bicyclic aromatic ring containing one sulfur atom, and two nitrogen atoms, wherein the sulfur atom is part of a thiophene ring and the nitrogen atoms are part of a pyrazoline ring fused therewith.
  • In one embodiment of the present invention X and Y are each independently selected from the group consisting of a direct bond, alkyl, and carbonyl;
      • with the proviso that both X and Y cannot be a direct bond; and when either X or Y is a direct bond, then the R1 or R2 associated with that bond is not phenyl or optionally substituted phenyl; and
        R1 and R2 are each independently selected from the group consisting of:
  • aryl, optionally substituted with cyano, alkoxy, halogen, alkylhalo, alkoxyhalo, carboxylalkyl, carbonylalkyl, benzyloxy, nitro, benzoyl, phenyl, carboxamido, or heteroaryl; and
  • heteroaryl, optionally substituted with aryl, heteroaryl, alkyl, halogen, alkylhalo, alkoxy, cycloalkyl or cyano.
  • The compounds of the present invention can exist as one or more stereoisomers. The various stereoisomers include geometric isomers, diastereomers and enantiomers. Thus the compounds of the present invention include racemic mixtures, individual stereoisomers and optically active mixtures. It will be appreciated by those skilled in the art that one stereoisomer may be more active than the others. Individual stereoisomers and optically active mixtures may be obtained by selective synthetic procedures, by conventional synthetic procedures using resolved starting materials or by conventional resolution procedures.
  • The compounds of the present invention can be prepared by known methods in the art as outlined in the examples of the present specification.
  • Another aspect of the present invention relates to an insecticidal or fungicidal composition comprising a compound of Formula (I) and a phytologically-acceptable inert carrier. The compositions are typically either concentrated formulations which are dispersed in water for application, or are dust or granular formulations which are applied without further treatment. The compositions are prepared according to procedures and formulae which are conventional in the agricultural chemical art, but which are novel and important because of the presence therein of the compounds of this invention. Some description of the formulation of the compositions will be given, however, to assure that agricultural chemists can readily prepare any desired composition.
  • The dispersions in which the compounds are applied are most often aqueous suspensions or emulsions prepared from concentrated formulations of the compounds. Such water-soluble, water-suspendable or emulsifiable formulations are either solids, usually known as wettable powders, or liquids usually known as emulsifiable concentrates or aqueous suspensions. Wettable powders, which may be compacted to form water dispersible granules, comprise an intimate mixture of the active compound, an inert carrier, and surfactants. The concentration of the active compound is usually from about 10% to about 90% by weight. The inert carrier is usually chosen from among the attapulgite clays, the montmorillonite clays, the diatomaceous earths, or the purified silicates. Effective surfactants, comprising from about 0.5% to about 10% of the wettable powder, are found among the sulfonated lignins, the condensed naphthalenesulfonates, the naphthalenesulfonates, the alkylbenzenesulfonates, the alkyl sulfates, and nonionic surfactants such as ethylene oxide adducts of alkyl phenols.
  • Emulsifiable concentrates of the compounds comprise a convenient concentration of a compound, such as from about 50 to about 500 grams per liter of liquid, equivalent to about 10% to about 50%, dissolved in an inert carrier which is either a water miscible solvent or a mixture of water-immiscible organic solvent and emulsifiers. Useful organic solvents include aromatics, especially the xylenes, and the petroleum fractions, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such as 2-ethoxyethanol. Suitable emulsifiers for emulsifiable concentrates are chosen from conventional nonionic surfactants, such as those discussed above.
  • Aqueous suspensions comprise suspensions of water-insoluble compounds of this invention, dispersed in an aqueous vehicle at a concentration in the range from about 5% to about 50% by weight. Suspensions are prepared by finely grinding the compound, and vigorously mixing it into a vehicle comprised of water and surfactants chosen from the same types discussed above. Inert ingredients, such as inorganic salts and synthetic or natural gums, may also be added, to increase the density and viscosity of the aqueous vehicle. It is often most effective to grind and mix the compound at the same time by preparing the aqueous mixture, and homogenizing it in an implement such as a sand mill, ball mill, or piston-type homogenizer.
  • The compounds may also be applied as granular compositions, which are particularly useful for applications to the soil. Granular compositions usually contain from about 0.5% to about 10% by weight of the compound, dispersed in an inert carrier which consists entirely or in large part of clay or a similar inexpensive substance. Such compositions are usually prepared by dissolving the compound in a suitable solvent and applying it to a granular carrier which has been pre-formed to the appropriate particle size, in the range of from about 0.5 to 3 mm. Such compositions may also be formulated by making a dough or paste of the carrier and compound and crushing and drying to obtain the desired granular particle size.
  • Dusts containing the compounds are prepared simply by intimately mixing the compound in powdered form with a suitable dusty agricultural carrier, such as kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1% to about 10% of the compound.
  • It is equally practical, when desirable for any reason, to apply the compound in the form of a solution in an appropriate organic solvent, usually a bland petroleum oil, such as the spray oils, which are widely used in agricultural chemistry.
  • Insecticides, acaricides and fungicides are generally applied in the form of a dispersion of the active ingredient in a liquid carrier. It is conventional to refer to application rates in terms of the concentration of active ingredient in the carrier. The most widely used carrier is water.
  • The compounds of the present invention can also be applied in the form of an aerosol composition. In such compositions the active compound is dissolved or dispersed in an inert carrier, which is a pressure-generating propellant mixture. The aerosol composition is packaged in a container from which the mixture is dispensed through an atomizing valve. Propellant mixtures comprise either low-boiling halocarbons, which may be mixed with organic solvents, or aqueous suspensions pressurized with inert gases or gaseous hydrocarbons.
  • The formulations may additionally contain adjuvant surfactants to enhance deposition, wetting and penetration of the compounds onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will typically vary from 0.01 to 1.0% by volume, based on a spray-volume of water, preferably 0.05 to 0.5 volume %. Suitable adjuvant surfactants include, but are not limited to ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts of the esters or sulphosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines and blends of surfactants with mineral or vegetable oils.
  • Another aspect of the present invention relates to a method for inhibiting an insect which comprises applying to a locus of the insect an insect-inhibiting amount of a compound of Formula (I).
  • The “locus” of insects is a term used herein to refer to the environment in which the insects live or where their eggs are present, including the air surrounding them, the food they eat, or objects which they contact. For example, insects which eat or contact edible or ornamental plants can be controlled by applying the active compound to plant parts such as the seed, seedling, or cutting which is planted, the leaves, stems, fruits, grain, or roots, or to the soil in which the roots are growing. It is contemplated that the compounds might also be useful to protect textiles, paper, stored grain, seeds, domesticated animals, buildings or human beings by applying an active compound to or near such objects. The term “inhibiting an insect” refers to a decrease in the numbers of living insects, or a decrease in the number of viable insect eggs. The extent of reduction accomplished by a compound depends, of course, upon the application rate of the compound, the particular compound used, and the target insect species. At least an inactivating amount should be used. The terms “insect-inactivating amount” are used to describe the amount, which is sufficient to cause a measurable reduction in the treated insect population. Generally an amount in the range from about 1 to about 1000 ppm by weight active compound is used.
  • The actual amount of compound to be applied to loci of insects and mites is not critical and can readily be determined by those skilled in the art in view of the examples above. In general, concentrations from 10 ppm to 5000 ppm by weight of compound are expected to provide good control. With many of the compounds, concentrations from 100 to 1500 ppm will suffice.
  • The locus to which a compound is applied can be any locus inhabited by an insect or mite, for example, vegetable crops, fruit and nut trees, grape vines, ornamental plants, domesticated animals, the interior or exterior surfaces of buildings, and the soil around buildings.
  • Another embodiment of the present invention is a method for the control or prevention of fungal attack. This method comprises applying to the soil, plant, roots, foliage, seed or locus of the fungus, or to a locus in which the infestation is to be prevented (for example applying to cereal or grape plants), a fungicidal effective amount of one or more of the compounds. The compounds are suitable for treatment of various plants at fungicidal levels, while exhibiting low phytotoxicity. The compounds are useful both in a protectant and/or an eradicant fashion.
  • The compounds have been found to have significant fungicidal effect particularly for agricultural use. Many of the compounds are particularly effective for use with agricultural crops and horticultural plants. It will be understood by those in the art that the efficacy of the compound for the foregoing fungi establishes the general utility of the compounds as fungicides.
  • The compounds have broad ranges of efficacy as fungicides. The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the fungal species to be controlled, and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally effective at similar concentrations or against the same fungal species.
  • The compounds are effective in use with plants in a disease-inhibiting and phytologically acceptable amount. The term “disease inhibiting and phytologically acceptable amount” refers to an amount of a compound that kills or inhibits the plant disease for which control is desired, but is not significantly toxic to the plant. This amount will generally be from about 0.1 to about 1000 ppm (parts per million), with 1 to 500 ppm being preferred. The exact concentration of compound required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like. A suitable application rate is typically in the range from about 0.10 to about 4 pounds/acre (about 0.01 to 0.45 grams per square meter, g/m2).
  • Additionally, the compounds of the present invention (Formula I) are often applied in conjunction with one or more other insecticides or fungicides to obtain control of a wider variety of pests and diseases. Such additional pesticidal compounds may be fungicides, insecticides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present invention in the medium selected for application, and not antagonistic to the activity of the present compounds. Accordingly, in such embodiments, the other pesticidal compound is employed as a supplemental toxicant for the same or for a different pesticidal use. The compounds of Formula I, and the pesticidal compound in the combination can generally be present in a weight ratio of from 1:100 to 100:1.
  • When used in conjunction with other insecticides or fungicides, the presently claimed compounds can be formulated with the other insecticides or fungicides, tank mixed with the other insecticides or fungicides, or applied sequentially with the other insecticides or fungicides.
  • Some of the insecticides that can be employed beneficially in combination with the compounds of the present invention include, but are not limited to: antibiotic insecticides such as allosamidin and thuringiensin; macrocyclic lactone insecticides such as spinosad; avermectin insecticides such as abamectin, doramectin, emamectin, eprinomectin, ivermectin and selamectin; milbemycin insecticides such as lepimectin, milbemectin, milbemycin oxime and moxidectin; arsenical insecticides such as calcium arsenate, copper acetoarsenite, copper arsenate, lead arsenate, potassium arsenite and sodium arsenite; botanical insecticides such as anabasine, azadirachtin, d-limonene, nicotine, pyrethrins, cinerins, cinerin I, cinerin II, jasmolin I, jasmolin II, pyrethrin I, pyrethrin II, quassia, rotenone, ryania and sabadilla; carbamate insecticides such as bendiocarb and carbaryl; benzofuranyl methylcarbamate insecticides such as benfuracarb, carbofuran, carbosulfan, decarbofuran and furathiocarb; dimethylcarbamate insecticides dimitan, dimetilan, hyquincarb and pirimicarb; oxime carbamate insecticides such as alanycarb, aldicarb, aldoxycarb, butocarboxim, butoxycarboxim, methomyl, nitrilacarb, oxamyl, tazimcarb, thiocarboxime, thiodicarb and thiofanox; phenyl methylcarbamate insecticides such as allyxycarb, aminocarb, bufencarb, butacarb, carbanolate, cloethocarb, dicresyl, dioxacarb, EMPC, ethiofencarb, fenethacarb, fenobucarb, isoprocarb, methiocarb, metolcarb, mexacarbate, promacyl, promecarb, propoxur, trimethacarb, XMC and xylylcarb; dinitrophenol insecticides such as dinex, dinoprop, dinosam and DNOC; fluorine insecticides such as barium hexafluorosilicate, cryolite, sodium fluoride, sodium hexafluorosilicate and sulfluramid; formamidine insecticides such as amitraz, chlordimeform, formetanate and formparanate; fumigant insecticides such as acrylonitrile, carbon disulfide, carbon tetrachloride, chloroform, chloropicrin, para-dichlorobenzene, 1,2-dichloropropane, ethyl formate, ethylene dibromide, ethylene dichloride, ethylene oxide, hydrogen cyanide, iodomethane, methyl bromide, methylchloroform, methylene chloride, naphthalene, phosphine, sulfuryl fluoride and tetrachloroethane; inorganic insecticides such as borax, calcium polysulfide, copper oleate, mercurous chloride, potassium thiocyanate and sodium thiocyanate; chitin synthesis inhibitors such as bistrifluoron, buprofezin, chlorfluazuron, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron and triflumuron; juvenile hormone mimics such as epofenonane, fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxyfen and triprene; juvenile hormones such as juvenile hormone I, juvenile hormone II and juvenile hormone III; moulting hormone agonists such as chromafenozide, halofenozide, methoxyfenozide and tebufenozide; moulting hormones such as α-ecdysone and ecdysterone; moulting inhibitors such as diofenolan; precocenes such as precocene I, precocene II and precocene III; unclassified insect growth regulators such as dicyclanil; nereistoxin analogue insecticides such as bensultap, cartap, thiocyclam and thiosultap; nicotinoid insecticides such as flonicamid; nitroguanidine insecticides such as clothianidin, dinotefuran, imidacloprid and thiamethoxam; nitromethylene insecticides such as nitenpyram and nithiazine; pyridylmethylamine insecticides such as acetamiprid, imidacloprid, nitenpyram and thiacloprid; organochlorine insecticides such as bromo-DDT, camphechlor, DDT, pp′-DDT, ethyl-DDD, HCH, gamma-HCH, lindane, methoxychlor, pentachlorophenol and TDE; cyclodiene insecticides such as aldrin, bromocyclen, chlorbicyclen, chlordane, chlordecone, dieldrin, dilor, endosulfan, endrin, HEOD, heptachlor, HHDN, isobenzan, isodrin, kelevan and mirex; organophosphate insecticides such as bromfenvinfos, chlorfenvinphos, crotoxyphos, dichlorvos, dicrotophos, dimethylvinphos, fospirate, heptenophos, methocrotophos, mevinphos, monocrotophos, naled, naftalofos, phosphamidon, propaphos, TEPP and tetrachlorvinphos; organothiophosphate insecticides such as dioxabenzofos, fosmethilan and phenthoate; aliphatic organothiophosphate insecticides such as acethion, amiton, cadusafos, chlorethoxyfos, chlormephos, demephion, demephion-O, demephion-S, demeton, demeton-O, demeton-S, demeton-methyl, demeton-O-methyl, demeton-S-methyl, demeton-S-methylsulphon, disulfoton, ethion, ethoprophos, IPSP, isothioate, malathion, methacrifos, oxydemeton-methyl, oxydeprofos, oxydisulfoton, phorate, sulfotep, terbufos and thiometon; aliphatic amide organothiophosphate insecticides such as amidithion, cyanthoate, dimethoate, ethoate-methyl, formothion, mecarbam, omethoate, prothoate, sophamide and vamidothion; oxime organothiophosphate insecticides such as chlorphoxim, phoxim and phoxim-methyl; heterocyclic organothiophosphate insecticides such as azamethiphos, coumaphos, coumithoate, dioxathion, endothion, menazon, morphothion, phosalone, pyraclofos, pyridaphenthion and quinothion; benzothiopyran organothiophosphate insecticides such as dithicrofos and thicrofos; benzotriazine organothiophosphate insecticides such as azinphos-ethyl and azinphos-methyl; isoindole organothiophosphate insecticides such as dialifos and phosmet; isoxazole organothiophosphate insecticides such as isoxathion and zolaprofos; pyrazolopyrimidine organothiophosphate insecticides such as chlorprazophos and pyrazophos; pyridine organothiophosphate insecticides such as chlorpyrifos and chlorpyrifos-methyl; pyrimidine organothiophosphate insecticides such as butathiofos, diazinon, etrimfos, lirimfos, pirimiphos-ethyl, pirimiphos-methyl, primidophos, pyrimitate and tebupirimfos; quinoxaline organothiophosphate insecticides such as quinalphos and quinalphos-methyl; thiadiazole organothiophosphate insecticides such as athidathion, lythidathion, methidathion and prothidathion; triazole organothiophosphate insecticides such as isazofos and triazophos; phenyl organothiophosphate insecticides such as azothoate, bromophos, bromophos-ethyl, carbophenothion, chlorthiophos, cyanophos, cythioate, dicapthon, dichlofenthion, etaphos, famphur, fenchlorphos, fenitrothion fensulfothion, fenthion, fenthion-ethyl, heterophos, jodfenphos, mesulfenfos, parathion, parathion-methyl, phenkapton, phosnichlor, profenofos, prothiofos, sulprofos, temephos, trichlormetaphos-3 and trifenofos; phosphonate insecticides such as butonate and trichlorfon; phosphonothioate insecticides such as mecarphon; phenyl ethylphosphonothioate insecticides such as fonofos and trichloronat; phenyl phenylphosphonothioate insecticides such as cyanofenphos, EPN and leptophos; phosphoramidate insecticides such as crufomate, fenamiphos, fosthietan, mephosfolan, phosfolan and pirimetaphos; phosphoramidothioate insecticides such as acephate, isocarbophos, isofenphos, methamidophos and propetamphos; phosphorodiamide insecticides such as dimefox, mazidox, mipafox and schradan; oxadiazine insecticides such as indoxacarb; phthalimide insecticides such as dialifos, phosmet and tetramethrin; pyrazole insecticides such as acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, tebufenpyrad, tolfenpyrad and vaniliprole; pyrethroid ester insecticides such as acrinathrin, allethrin, bioallethrin, barthrin, bifenthrin, bioethanomethrin, cyclethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, dimefluthrin, dimethrin, empenthrin, fenfluthrin, fenpirithrin, fenpropathrin, fenvalerate, esfenvalerate, flucythrinate, fluvalinate, tau-fluvalinate, furethrin, imiprothrin, metofluthrin, permethrin, biopermethrin, transpermethrin, phenothrin, prallethrin, profluthrin, pyresmethrin, resmethrin, bioresmethrin, cismethrin, tefluthrin, terallethrin, tetramethrin, tralomethrin and transfluthrin; pyrethroid ether insecticides such as etofenprox, flufenprox, halfenprox, protrifenbute and silafluofen; pyrimidinamine insecticides such as flufenerim and pyrimidifen; pyrrole insecticides such as chlorfenapyr; tetronic acid insecticides such as spiromesifen; thiourea insecticides such as diafenthiuron; urea insecticides such as flucofuron and sulcofuron; and unclassified insecticides such as closantel, crotamiton, EXD, fenazaflor, fenoxacrim, flubendiamide, hydramethylnon, isoprothiolane, malonoben, metaflumizone, metoxadiazone, nifluridide, pyridaben, pyridalyl, rafoxanide, triarathene and triazamate and any combinations thereof.
  • Some of the fungicides that can be employed beneficially in combination with the compounds of the present invention include, but are not limited to: enestrobin, antimycin, quinoxyfen, SYP-048, IK-1140, NC-224, 2-(thiocyanatomethylthio)-benzothiazole, 2-phenylphenol, 8-hydroxyquinoline sulfate, Ampelomyces, quisqualis, azaconazole, azoxystrobin, Bacillus subtilis, benalaxyl, benomyl, benthiavalicarb-isopropyl, benzylaminobenzene-sulfonate (BABS) salt, bicarbonates, biphenyl, bismerthiazol, bitertanol, blasticidin-S, borax, Bordeaux mixture, boscalid, bromuconazole, bupirimate, calcium polysulfide, captafol, captan, carbendazim, carboxin, carpropamid, carvone, chloroneb, chlorothalonil, chlozolinate, Coniothyrium minitans, copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), cuprous oxide, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, dazomet, debacarb, diammonium ethylenebis-(dithiocarbamate), dichlofluanid, dichlorophen, diclocymet, diclomezine, dichloran, diethofencarb, difenoconazole, difenzoquat ion, diflumetorim, dimethomorph, dimoxystrobin, diniconazole, diniconazole-M, dinobuton, dinocap, diphenylamine, dithianon, dodemorph, dodemorph acetate, dodine, dodine free base, edifenphos, epoxiconazole, ethaboxam, ethoxyquin, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fentin, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumorph, fluopicolide, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet, formaldehyde, fosetyl, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, guazatine acetates, GY-81, hexachlorobenzene, hexaconazole, hymexazol, imazalil, imazalil sulfate, imibenconazole, iminoctadine, iminoctadine triacetate, iminoctadine tris(albesilate), ipconazole, iprobenfos, iprodione, iprovalicarb, isoprothiolane, kasugamycin, kasugamycin hydrochloride hydrate, kresoxim-methyl, mancopper, mancozeb, maneb, mepanipyrim, mepronil, mercuric chloride, mercuric oxide, mercurous chloride, metalaxyl, mefenoxam, metalaxyl-M, metam, metam-ammonium, metam-potassium, metam-sodium, metconazole, methasulfocarb, methyl iodide, methyl isothiocyanate, metiram, metominostrobin, metrafenone, mildiomycin, myclobutanil, nabam, nitrothal-isopropyl, nuarimol, octhilinone, ofurace, oleic acid (fatty acids), orysastrobin, oxadixyl, oxine-copper, oxpoconazole fumarate, oxycarboxin, pefurazoate, penconazole, pencycuron, pentachlorophenol, pentachlorophenyl laurate, penthiopyrad, phenylmercury acetate, phosphonic acid, phthalide, picoxystrobin, polyoxin B, polyoxins, polyoxorim, potassium bicarbonate, potassium hydroxyquinoline sulfate, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, proquinazid, prothioconazole, pyraclostrobin, pyrazophos, pyributicarb, pyrifenox, pyrimethanil, pyroquilon, quinoclamine, quinoxyfen, quintozene, Reynoutria sachalinensis extract, silthiofam, simeconazole, sodium 2-phenylphenoxide, sodium bicarbonate, sodium pentachlorophenoxide, spiroxamine, sulfur, SYP-Z071, tar oils, tebuconazole, tecnazene, tetraconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin, vinclozolin, zineb, ziram, zoxamide, Candida oleophila, Fusarium oxysporum, Gliocladium spp., Phlebiopsis gigantean, Streptomyces griseoviridis, Trichoderma spp., (RS)—N-(3,5-dichlorophenyl)-2-(methoxymethyl)-succinimide, 1,2-dichloropropane, 1,3-dichloro-1,1,3,3-tetrafluoroacetone hydrate, 1-chloro-2,4-dinitronaphthalene, 1-chloro-2-nitropropane, 2-(2-heptadecyl-2-imidazolin-1-yl)ethanol, 2,3-dihydro-5-phenyl-1,4-dithi-ine 1,1,4,4-tetraoxide, 2-methoxyethylmercury acetate, 2-methoxyethylmercury chloride, 2-methoxyethylmercury silicate, 3-(4-chlorophenyl)-5-methylrhodanine, 4-(2-nitroprop-1-enyl)phenyl thiocyanateme: ampropylfos, anilazine, azithiram, barium polysulfide, Bayer 32394, benodanil, benquinox, bentaluron, benzamacril; benzamacril-isobutyl, benzamorf, binapacryl, bis(methylmercury) sulfate, bis(tributyltin) oxide, buthiobate, cadmium calcium copper zinc chromate sulfate, carbamorph, CECA, chlobenthiazone, chloraniformethan, chlorfenazole, chlorquinox, climbazole, copper bis(3-phenylsalicylate), copper zinc chromate, cufraneb, cupric hydrazinium sulfate, cuprobam, cyclafuramid, cypendazole, cyprofuram, decafentin, dichlone, dichlozoline, diclobutrazol, dimethirimol, dinocton, dinosulfon, dinoterbon, dipyrithione, ditalimfos, dodicin, drazoxolon, EBP, ESBP, etaconazole, etem, ethirim, fenaminosulf, fenapanil, fenitropan, fluotrimazole, furcarbanil, furconazole, furconazole-cis, furmecyclox, furophanate, glyodine, griseofulvin, halacrinate, Hercules 3944, hexylthiofos, ICIA0858, isopamphos, isovaledione, mebenil, mecarbinzid, metazoxolon, methfuroxam, methylmercury dicyandiamide, metsulfovax, milneb, mucochloric anhydride, myclozolin, N-3,5-dichlorophenyl-succinimide, N-3-nitrophenyl-itaconimide, natamycin, N-ethylmercurio-4-toluenesulfonanilide, nickel bis(dimethyldithiocarbamate), OCH, phenylmercury dimethyldithiocarbamate, phenylmercury nitrate, phosdiphen, prothiocarb; prothiocarb hydrochloride, pyracarbolid, pyridinitril, pyroxychlor, pyroxyfur, quinacetol; quinacetol sulfate, quinazamid, quinconazole, rabenzazole, salicylanilide, SSF-109, sultropen, tecoram, thiadifluor, thicyofen, thiochlorfenphim, thiophanate, thioquinox, tioxymid, triamiphos, triarimol, triazbutil, trichlamide, urbacid, XRD-563, and zarilamid, and any combinations thereof.
    • EXAMPLES
  • Throughout the present specification, all temperatures are given in degrees Celsius, and all percentages are weight percentages unless otherwise stated. The following examples are representative of the embodiments of the present invention and should not be read as limiting.
  • The compounds of the present invention may be synthesized by methods that are individually known to those skilled in the art.
  • The compounds of Formula I wherein R1, R2, X, Y, are previously defined can be prepared by the methods illustrated in the following schemes.
  • Figure US20130072497A1-20130321-C00004
  • In step a, of scheme A, alcohol 1 is treated with methan sulfonyl chloride and triethylamine (Et3N) at 0° C. to yield mesylate 2, which undergoes a nucleophilic displacement with piperazine in step b, to deliver compound 4. The preferred solvent for the nucleophilic displacement is acetonitrile (CH3CN) and elevated temperatures are required to drive the reaction to completion. Commercial mono-substituted piperazines were used directly in schemes B and C when available.
  • Figure US20130072497A1-20130321-C00005
  • As depicted in step a, a substituted piperazine, 4, is reacted with an acid chloride 5 to yield the appropriately acyl piperazine 6. The acylation is performed under basic conditions to neutralize the hydrochloric acid (HCl) formed during the reaction; examples of typical bases are diispropylamine (DIEA) and Et3N.
  • Figure US20130072497A1-20130321-C00006
  • As depicted in Scheme C, a substituted piperazine, 4, is reacted with chloro derivative 7 (note bromides can also be used) and heated at 80° C. in dimethylformamide (DMF) to give the appropriately substituted piperazine 8. The reaction is performed under basic conditions to neutralize the HCl formed during the reaction; examples of typical bases are DIEA and Et3N.
  • Alternatively, t-butylcarbamate (BOC) protected piperazine can be utilized as illustrated in schemes D and E. In step a, of scheme D, BOC protected piperazine is N-acylated with an acid chloride utilizing similar reactions previously described to yield compound 10. The BOC group is removed with trifluoroacetic acid (TFA) in methylene chloride (CH2Cl2) and the free base 11, is N-alkylated, again utilizing reaction conditions described earlier, to yield derivatives of 6.
  • Figure US20130072497A1-20130321-C00007
  • The N-acylation and N-alkylation steps in scheme D can be reversed as shown in scheme E to deliver derivatives of 6.
  • Figure US20130072497A1-20130321-C00008
  • The following examples further illustrate the present invention, but, are not to be construed as in any way limiting its scope.
    • Example I 1-Benzyl-4-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperazine (14)
  • Figure US20130072497A1-20130321-C00009
  • To a 2-dram screw-cap vial was added polymer-supported diisopropylethylamine (PS-DIEA, 54 mg, 0.2 mmol based on 3.68 mmol/g loading of resin) and DMF (2 mL). The vials were placed in an orbital shaker allowed to shake for 15 min 1-Benzylpiperazine (35 mg, 0.2 mmol) was dissolved in DMF (100 μL) and transferred by pipette to the vial. 3,5-Dimethylisoxazole-4-carbonyl chloride (32 mg, 0.2 mmol), was dissolve in DMF (100 μL) and transferred to the vial. The vial was capped and allowed to shake at room temperature (RT) for 12 h. The reaction mixture filtered and solvent evaporated to give the desired acylated piperazine. MS ELS+ 300.
    • Example II 1-(2-methyoxybenzoyl)-4-{2-[2-trifluoromethyl)phenyl]ethyl}piperazine (15)
  • Figure US20130072497A1-20130321-C00010
  • 1-[2-(Trifluoromethyl)phenethyl]piperazine (200 mg, 0.60 mmol), o-anisyl chloride (100 mg, 0.59 mmol), and Et3N (253 μL, 1.81 mmol) were dissolved in DMF (10 mL) and stirred at ambient temperature for 12 h. The reaction mixture was extracted with diethylether (Et2O) and the combined organic layers washed with brine, dried over anhydrous sodium sulfate (Na2SO4) and evaporated to give an amber oil (120 mg, 51%). 1H NMR (CDCl3) δ: 2.4-2.7 (m, 6H), 2.9-3.0 (t, 2H), 3.2-3.35 (m, 2H), 3.8-3.95 (m, 5H), 6.89-7.01 (m, 2H), 7.22-7.37 (m, 4H), 7.43-7.49 (t, 1H), 7.59-7.62 (d, 1H). MS ELS+ 393.
    • Example III 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-4-(2-phenoxyethyl)piperazine (16)
  • Figure US20130072497A1-20130321-C00011
  • 1-[2-(phenoxy)-ethyl]piperazine (200 mg, 0.974 mmol), 6-chloropiperonyl chloride (200 mg, 0.974 mmol), and Et3N (415 μL, 3 mmol) were combined in tetrahydrofuran (THF 20 mL).
  • The reaction mixture was heated at 60° C. for 12 h. The reaction mixture was cooled and extracted with ethyl acetate (EtOAc). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and evaporated. The crude residue was chromatographed on silica (20% EtOAc/Hexanes) and the product fractions were collected and evaporated to an amber solid (186 mg, 51%). 1H NMR (CDCl3) δ: 2.5-2.7 (m, 8H), 2.8 (t, 2H), 3.5 (s, 2H), 4.1 (t, 2H), 5.9 (s, 2H), 6.81 (s, 1H), 6.9-6.94 (m, 3H), 6.96-6.98 (m, 1H), 7.26-7.3 (m, 1H). MS ELS+ 376. CHN: calc., 64.08, 6.18, 7.47. found, 63.87, 6.12, 7.44. mp: 72-76° C.
    • Example IV 3-{[4-(2-phenylethyl)piperazin-1-yl]methyl}benzonitrile (17)
  • Figure US20130072497A1-20130321-C00012
  • To a 2-dram screw-cap vial was added PS-DIEA (54 mg, 0.2 mmol) and DMF (2 mL). The vials were placed in an orbital shaker allowed to shake for 15 min 1-(2-phenylethyl)-piperazine (38 mg, 0.2 mmol was dissolved in DMF (100 μL) and transferred by pipette to the vial. 3-Chloromethylbenzonitrile (30 mg, 0.2 mmol), was dissolve in DMF (100 μL) and transferred to the vial. The vial was capped and heated at 80° C. with shaking for 12 h. The vial was cooled to RT and the reaction mixture filtered and solvent evaporated to give the desired substituted piperazine. MS ELS+ 306.
    • Intermediate Compound 2-(2,4-dichlorophenyl)ethyl methanesulfonate (18)
  • Figure US20130072497A1-20130321-C00013
  • To a stirred mixture of 2,4-dichlorophenethylalcohol (955.0 mg, 5.0 mol) at 0° C. was added Et3N (1.1 mL, 7.5 mmol) and stirred for 5 min. Methane sulfonyl chloride (572.8 mg, 5.0 mmol) was added neat, dropwise by syringe. A precipitate formed and the reaction mixture stirred 30 min. The mixture was filtered, diluted with Et2O (20 mL) and cooled at to 0° C. After 20 min., the mixture was filtered through a pad of silica, dried over anhydrous Na2SO4 and evaporated. The crude residue was co-evaporated with toluene and chloroform (1:1) to give a yellow oil (1.1 g, 80%). The mesylate was used directly in subsequent reactions. 1H NMR (CDCl3) δ 2.9 (s, 3H), 3.18 (t, 2H), 4.42 (t, 2H), 7.22 (d, 2H), 7.41 (t, 1H).
    • Intermediate Compound 1-[(2-(2,4-dichlorophenyl)ethyl]piperazine (19)
  • Figure US20130072497A1-20130321-C00014
  • piperazine (1.9 g, 22 mmol) was stirred in 20 mL CH3CN at 75° C. Compound 19 (1.1 g, 4.1 mmol) was dissolved in CH3CN (2 mL) and added dropwise via syringe. The reaction mixture was heated at 60° C. for 30 min. The mixture was poured over ice and extracted with EtOAC. The combined organic layers were washed with water, dried over anhydrous magnesium sulfate (MgSO4), and evaporated to yield the desired piperazine as a yellow oil (826 mg, 80%). 1H NMR (CDCl3) δ 2.55 (bm, 6H), 2.9 (bm, 6H), 7.19 (d, 2H), 7.36 (t, 1H)
    • Example V tert-butyl 4-(2-phenylpropanoyl)piperazine-1-carboxylate (20)
  • Figure US20130072497A1-20130321-C00015
  • To a stirred mixture of 2-phenyl propionic acid (1.0 g, 6.7 mmol) in 1,2-dichloroethane (15 mL) was added a few drops of DMF and excess thionyl chloride. The resulting mixture was heated at reflux for 2 h, when bubbling ceased the mixture was evaporated to dryness. The crude residue was co-evaporated with toluene and 1,2-dichloroethane. The residue was dissolved in CH2Cl2 and cooled to 0° C. To the stirred solution, BOC-piperazine (1.24 g, 6.7 mmol) and Et3N were added. A white precipitate formed and the reaction was stirred 12 h at RT. Et2O was added and the mixture was washed with water and brine. The ether layer was separated and dried over anhydrous Na2SO4, filtered, and evaporated. The residue was treated with 20% ether/hexanes and the resulting solid filtered. The filtrate was evaporated and the procedure repeated. After drying, there remained a white solid (1.3 g, 62%). 1H NMR (CDCl3) δ: 1.4 (s, 9H), 1.42 (d, 3H), 2.7 (m, 1H), 3.1-3.6 (m, 6H), 3.85 (m, 2H), 7.2-7.4 (m, 5H). [M+Na] 341.
    • Example VI 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-4-(2-phenylpropanoyl)piperazine (21)
  • Figure US20130072497A1-20130321-C00016
  • To a stirred mixture of compound 201 (500 mg, 1.57 mmol) in CH2Cl2 was added trifluoroacetic acid TFA (excess). The mixture was stirred 1 h and was evaporated to dryness. The crude residue was dissolved in DMF and 6-chloropiperonyl chloride (321 mg, 1.57 mmol), and Et3N were added. The reaction mixture was stirred at 80° C. for 3 h after which the mixture was poured into water and extracted with Et2O. The combined Et2O layers were washed with water, brine and dried over anhydrous Na2SO4, filtered, and evaporated to give orange oil (500 mg, 83%). 1H NMR (CDCl3) δ: 1.42 (d, 3H), 1.95 (m, 1H), 2.25-2.5 (m, 3H), 3.2-3.8 (bm, 4H), 3.41 (s, 2H), 3.85 (q, 1H), 5.95 (s, 2H), 6.79 (s, 1H), 6.9 (s, 1H), 7.2-7.35 (m, 5H).
    • Example VII 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-4-(2-phenylpropyl)piperazine (22)
  • Figure US20130072497A1-20130321-C00017
  • To a stirred mixture of compound 21 (200, mg 0.52 mmol) in THF (7.0 mL) was added lithium aluminum hydride (LAH) (0.4 mL of 1M in THF). The mixture was refluxed for 1 h. To the cooled mixture was added ice-water to quench unreacted LAH. The mixture was stirred 1 h and extracted with Et2O and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, and evaporated. The crude residue was purified via flash column (20% EtOAc/Hexanes) and the product fractions evaporated to give an orange oil (179.8 mg, 93%). 1H NMR (CDCl3) δ: 1.15 (d, 3H), 2.35-2.55 (bm, 10H), 2.9 (m, 1H), 3.5 (s, 2H), 5.98 (s, 2H), 6.8 (s, 1H), 6.95 (s, 1H) 7.18-7.35 (m, 5H). GC-MS: calcd, 372. found, 372.
  • TABLE 1 lists compounds of the invention prepared according to the procedures described in Scheme A-D as well as illustrated by Examples I-VII.
  • TABLE 1
    Compound # Structure Characterization
    23
    Figure US20130072497A1-20130321-C00018
         		[M + H]+: 288
    24
    Figure US20130072497A1-20130321-C00019
         		[M + H]+: 306
    25
    Figure US20130072497A1-20130321-C00020
         		[M + H]+: 294
    26
    Figure US20130072497A1-20130321-C00021
         		[M + H]+: 355
    27
    Figure US20130072497A1-20130321-C00022
         		[M + H]+: 343
    28
    Figure US20130072497A1-20130321-C00023
         		[M + H]+: 316
    29
    Figure US20130072497A1-20130321-C00024
         		[M + H]+: 304
    30
    Figure US20130072497A1-20130321-C00025
         		[M + H]+: 325
    31
    Figure US20130072497A1-20130321-C00026
         		[M + H]+: 313
    32
    Figure US20130072497A1-20130321-C00027
         		[M + H]+: 282
    33
    Figure US20130072497A1-20130321-C00028
         		[M + H]+: 270
    34
    Figure US20130072497A1-20130321-C00029
         		[M + H]+: 271
    35
    Figure US20130072497A1-20130321-C00030
         		[M + H]+: 259
    36
    Figure US20130072497A1-20130321-C00031
         		[M + H]+: 295
    37
    Figure US20130072497A1-20130321-C00032
         		[M + H]+: 283
    38
    Figure US20130072497A1-20130321-C00033
         		[M + H]+: 329, 331
    39
    Figure US20130072497A1-20130321-C00034
         		[M + H]+: 317
    40
    Figure US20130072497A1-20130321-C00035
         		[M + H]+: 311
    41
    Figure US20130072497A1-20130321-C00036
         		[M + H]+: 299
    42
    Figure US20130072497A1-20130321-C00037
         		[M + H]+: 306
    43
    Figure US20130072497A1-20130321-C00038
         		[M + H]+: 294
    44
    Figure US20130072497A1-20130321-C00039
         		[M + H]+: 315, 317
    45
    Figure US20130072497A1-20130321-C00040
         		[M + H]+: 303
    46
    Figure US20130072497A1-20130321-C00041
         		[M + H]+: 339
    47
    Figure US20130072497A1-20130321-C00042
         		[M + H]+: 327
    48
    Figure US20130072497A1-20130321-C00043
         		[M + H]+: 299
    49
    Figure US20130072497A1-20130321-C00044
         		[M + H]+: 287
    50
    Figure US20130072497A1-20130321-C00045
         		[M + H]+: 321
    51
    Figure US20130072497A1-20130321-C00046
         		[M + H]+: 309
    52
    Figure US20130072497A1-20130321-C00047
         		[M + H]+: 301
    53
    Figure US20130072497A1-20130321-C00048
         		[M + H]+: 289
    54
    Figure US20130072497A1-20130321-C00049
         		[M + H]+: 261
    55
    Figure US20130072497A1-20130321-C00050
         		[M + H]+: 249
    56
    Figure US20130072497A1-20130321-C00051
         		[M + H]+: 309
    57
    Figure US20130072497A1-20130321-C00052
         		[M + H]+: 331, 333
    58
    Figure US20130072497A1-20130321-C00053
         		[M + H]+: 393
    59
    Figure US20130072497A1-20130321-C00054
         		[M + H]+: 339
    60
    Figure US20130072497A1-20130321-C00055
         		[M + H]+: 407
    61
    Figure US20130072497A1-20130321-C00056
         		[M + H]+: 353
    62
    Figure US20130072497A1-20130321-C00057
         		[M + H]+: 339
    63
    Figure US20130072497A1-20130321-C00058
         		[M + H]+: 369
    64
    Figure US20130072497A1-20130321-C00059
         		[M + H]+: 437
    65
    Figure US20130072497A1-20130321-C00060
         		[M + H]+: 383
    66
    Figure US20130072497A1-20130321-C00061
         		[M + H]+: 391
    67
    Figure US20130072497A1-20130321-C00062
         		[M + H]+: 413
    68
    Figure US20130072497A1-20130321-C00063
         		[M + H]+: 359
    69
    Figure US20130072497A1-20130321-C00064
         		[M + H]+: 345
    70
    Figure US20130072497A1-20130321-C00065
         		[M + H]+: 375
    71
    Figure US20130072497A1-20130321-C00066
         		[M + H]+: 326
    72
    Figure US20130072497A1-20130321-C00067
         		[M + H]+: 396
    73
    Figure US20130072497A1-20130321-C00068
         		[M + H]+: 345
    74
    Figure US20130072497A1-20130321-C00069
         		[M + H]+: 360
    75
    Figure US20130072497A1-20130321-C00070
         		[M + H]+: 407
    76
    Figure US20130072497A1-20130321-C00071
         		[M + H]+: 353
    77
    Figure US20130072497A1-20130321-C00072
         		[M + H]+: 353
    78
    Figure US20130072497A1-20130321-C00073
         		[M + H]+: 299
    79
    Figure US20130072497A1-20130321-C00074
         		[M + Na]: 337
    80
    Figure US20130072497A1-20130321-C00075
         		[M + H]+: 399
    81
    Figure US20130072497A1-20130321-C00076
         		[M + H]+: 389
    82
    Figure US20130072497A1-20130321-C00077
         		[M + H]+: 383
    83
    Figure US20130072497A1-20130321-C00078
         		[M + H]+: 384, 386
    84
    Figure US20130072497A1-20130321-C00079
         		[M + H]+: 329
    85
    Figure US20130072497A1-20130321-C00080
         		[M + H]+: 315
    86
    Figure US20130072497A1-20130321-C00081
         		[M + H]+: 427, 430
    87
    Figure US20130072497A1-20130321-C00082
         		[M + H]+: 407
    88
    Figure US20130072497A1-20130321-C00083
         		[M + H]+: 439
    89
    Figure US20130072497A1-20130321-C00084
         		[M + H]+: 386
    90
    Figure US20130072497A1-20130321-C00085
         		[M + H]+: 339
    91
    Figure US20130072497A1-20130321-C00086
         		[M + H]+: 365
    92
    Figure US20130072497A1-20130321-C00087
         		[M + H]+: 373
    93
    Figure US20130072497A1-20130321-C00088
         		[M + H]+: 357
    94
    Figure US20130072497A1-20130321-C00089
         		[M + H]+: 345
    95
    Figure US20130072497A1-20130321-C00090
         		[M + H]+: 413
    96
    Figure US20130072497A1-20130321-C00091
         		[GC − MS]: 357
    97
    Figure US20130072497A1-20130321-C00092
         		[M + H]+: 407
    98
    Figure US20130072497A1-20130321-C00093
         		[M + H]+: 393
    99
    Figure US20130072497A1-20130321-C00094
         		[M + H]+: 454
    100
    Figure US20130072497A1-20130321-C00095
         		[M + H]+: 407
    101
    Figure US20130072497A1-20130321-C00096
         		[GC − MS]: 382
    102
    Figure US20130072497A1-20130321-C00097
         		[GC − MS]: 364
    103
    Figure US20130072497A1-20130321-C00098
         		[M + H]+: 375
    104
    Figure US20130072497A1-20130321-C00099
         		[GC − MS]: 358
    105
    Figure US20130072497A1-20130321-C00100
         		[M + H]+: 405
    106
    Figure US20130072497A1-20130321-C00101
         		[GC − MS]: 358
    107
    Figure US20130072497A1-20130321-C00102
         		[GC − MS]: 3927
    108
    Figure US20130072497A1-20130321-C00103
         		[M + H]+: 443
    109
    Figure US20130072497A1-20130321-C00104
         		[M + H]+: 355
    110
    Figure US20130072497A1-20130321-C00105
         		[M + H]+: 358
    111
    Figure US20130072497A1-20130321-C00106
         		[M + H]+: 403
    112
    Figure US20130072497A1-20130321-C00107
         		[M + H]+: 387
    113
    Figure US20130072497A1-20130321-C00108
         		[M + H]+: 421
    114
    Figure US20130072497A1-20130321-C00109
         		[M + H]+: 351
    115
    Figure US20130072497A1-20130321-C00110
         		[M + H]+: 437
    116
    Figure US20130072497A1-20130321-C00111
         		[M + H]+: 369
    117
    Figure US20130072497A1-20130321-C00112
         		[M + H]+: 315
    118
    Figure US20130072497A1-20130321-C00113
         		[M + H]+: 345
    119
    Figure US20130072497A1-20130321-C00114
         		[M + H]+: 414
    120
    Figure US20130072497A1-20130321-C00115
         		[M + H]+: 369
    121
    Figure US20130072497A1-20130321-C00116
         		[M + H]+: 315
    122
    Figure US20130072497A1-20130321-C00117
         		[M + H]+: 301
    123
    Figure US20130072497A1-20130321-C00118
         		[M + H]+: 331
    124
    Figure US20130072497A1-20130321-C00119
         		[M + H]+: 381
    125
    Figure US20130072497A1-20130321-C00120
         		[M + H]+: 327
    126
    Figure US20130072497A1-20130321-C00121
         		[M + H]+: 446
    127
    Figure US20130072497A1-20130321-C00122
         		[M + H]+: 339
    128
    Figure US20130072497A1-20130321-C00123
         		[M + H]+: 385
    129
    Figure US20130072497A1-20130321-C00124
         		[M + H]+: 380
    130
    Figure US20130072497A1-20130321-C00125
         		[M + H]+: 368
    131
    Figure US20130072497A1-20130321-C00126
         		[M + H]+: 299
    132
    Figure US20130072497A1-20130321-C00127
         		[M + H]+: 366
    133
    Figure US20130072497A1-20130321-C00128
         		[M + H]+: 288
    134
    Figure US20130072497A1-20130321-C00129
         		[M + H]+: 305
    135
    Figure US20130072497A1-20130321-C00130
         		[M + H]+: 287
    136
    Figure US20130072497A1-20130321-C00131
         		[M + H]+: 275
    137
    Figure US20130072497A1-20130321-C00132
         		[M + H]+: 300
    138
    Figure US20130072497A1-20130321-C00133
         		[M + H]+: 297
    139
    Figure US20130072497A1-20130321-C00134
         		[M + H]+: 355
    140
    Figure US20130072497A1-20130321-C00135
         		[M + H]+: 398
    141
    Figure US20130072497A1-20130321-C00136
         		[M + H]+: 330
    142
    Figure US20130072497A1-20130321-C00137
         		[M + H]+: 285
    143
    Figure US20130072497A1-20130321-C00138
         		[M + H]+: 475
    144
    Figure US20130072497A1-20130321-C00139
         		[M + H]+: 407
    145
    Figure US20130072497A1-20130321-C00140
         		[M + H]+: 301
    146
    Figure US20130072497A1-20130321-C00141
         		[M + H]+: 331
    147
    Figure US20130072497A1-20130321-C00142
         		[M + H]+: 313
    148
    Figure US20130072497A1-20130321-C00143
         		[M + H]+: 343
    149
    Figure US20130072497A1-20130321-C00144
         		[M + H]+: 378
    150
    Figure US20130072497A1-20130321-C00145
         		[M + H]+: 392
    151
    Figure US20130072497A1-20130321-C00146
         		[M + H]+: 378
    152
    Figure US20130072497A1-20130321-C00147
         		[M + H]+: 408
    153
    Figure US20130072497A1-20130321-C00148
         		[M + H]+: 410
    154
    Figure US20130072497A1-20130321-C00149
         		[M + H]+: 356
    155
    Figure US20130072497A1-20130321-C00150
         		[M + H]+: 342
    156
    Figure US20130072497A1-20130321-C00151
         		[M + H]+: 414
    157
    Figure US20130072497A1-20130321-C00152
         		[M + H]+: 360
    158
    Figure US20130072497A1-20130321-C00153
         		[M + H]+: 346
    159
    Figure US20130072497A1-20130321-C00154
         		[M + H]+: 376
    160
    Figure US20130072497A1-20130321-C00155
         		[M + H]+: 437
    161
    Figure US20130072497A1-20130321-C00156
         		[M + H]+: 382
    162
    Figure US20130072497A1-20130321-C00157
         		[M + H]+: 369
    163
    Figure US20130072497A1-20130321-C00158
         		[M + H]+: 399
    164
    Figure US20130072497A1-20130321-C00159
         		[M + H]+: 368
    165
    Figure US20130072497A1-20130321-C00160
         		[M + H]+: 314
    166
    Figure US20130072497A1-20130321-C00161
         		[M + H]+: 300
    167
    Figure US20130072497A1-20130321-C00162
         		[M + H]+: 405
    168
    Figure US20130072497A1-20130321-C00163
         		[M + H]+: 351
    169
    Figure US20130072497A1-20130321-C00164
         		[M + H]+: 337
    170
    Figure US20130072497A1-20130321-C00165
         		[M + H]+: 367
    171
    Figure US20130072497A1-20130321-C00166
         		[M + H]+: 349
    172
    Figure US20130072497A1-20130321-C00167
         		[M + H]+: 335
    173
    Figure US20130072497A1-20130321-C00168
         		[M + H]+: 365
    174
    Figure US20130072497A1-20130321-C00169
         		[M + H]+: 371
    175
    Figure US20130072497A1-20130321-C00170
         		[M + H]+: 317
    176
    Figure US20130072497A1-20130321-C00171
         		[M + H]+: 303
    177
    Figure US20130072497A1-20130321-C00172
         		[M + H]+: 333
    178
    Figure US20130072497A1-20130321-C00173
         		[M + H]+: 379
    179
    Figure US20130072497A1-20130321-C00174
         		[M + H]+: 311
    180
    Figure US20130072497A1-20130321-C00175
         		[M + H]+: 341
    181
    Figure US20130072497A1-20130321-C00176
         		[M + H]+: 353
    182
    Figure US20130072497A1-20130321-C00177
         		[M + H]+: 369
    183
    Figure US20130072497A1-20130321-C00178
         		[M + H]+: 437
    184
    Figure US20130072497A1-20130321-C00179
         		[M + H]+: 383
    185
    Figure US20130072497A1-20130321-C00180
         		[M + H]+: 369
    186
    Figure US20130072497A1-20130321-C00181
         		[M + H]+: 399
    187
    Figure US20130072497A1-20130321-C00182
         		[M + H]+: 331
    188
    Figure US20130072497A1-20130321-C00183
         		[M + H]+: 361
    189
    Figure US20130072497A1-20130321-C00184
         		[M + H]+: 312
    190
    Figure US20130072497A1-20130321-C00185
         		[M + H]+: 330
    191
    Figure US20130072497A1-20130321-C00186
         		[M + H]+: 316
    192
    Figure US20130072497A1-20130321-C00187
         		[M + H]+: 346
    193
    Figure US20130072497A1-20130321-C00188
         		[M + H]+: 365
    194
    Figure US20130072497A1-20130321-C00189
         		[M + H]+: 351
    195
    Figure US20130072497A1-20130321-C00190
         		[M + H]+: 381
    196
    Figure US20130072497A1-20130321-C00191
         		[M + H]+: 373
    197
    Figure US20130072497A1-20130321-C00192
         		[M + H]+: 359
    198
    Figure US20130072497A1-20130321-C00193
         		[M + H]+: 389
    199
    Figure US20130072497A1-20130321-C00194
         		[M + H]+: 353
    200
    Figure US20130072497A1-20130321-C00195
         		[M + H]+: 369
    201
    Figure US20130072497A1-20130321-C00196
         		[M + H]+: 417
    202
    Figure US20130072497A1-20130321-C00197
         		[M + H]+: 349
    203
    Figure US20130072497A1-20130321-C00198
         		[M + H]+: 379
    204
    Figure US20130072497A1-20130321-C00199
         		[M + H]+: 447
    205
    Figure US20130072497A1-20130321-C00200
         		[M + H]+: 393
    206
    Figure US20130072497A1-20130321-C00201
         		[M + H]+: 379
    207
    Figure US20130072497A1-20130321-C00202
         		[M + H]+: 409
    208
    Figure US20130072497A1-20130321-C00203
         		[M + H]+: 261
    209
    Figure US20130072497A1-20130321-C00204
         		[M + H]+: 368
    210
    Figure US20130072497A1-20130321-C00205
         		[M + H]+: 314
    211
    Figure US20130072497A1-20130321-C00206
         		[M + H]+: 300
    212
    Figure US20130072497A1-20130321-C00207
         		[M + H]+: 330
    213
    Figure US20130072497A1-20130321-C00208
         		[M + H]+: 323
    214
    Figure US20130072497A1-20130321-C00209
         		[M + H]+: 309
    215
    Figure US20130072497A1-20130321-C00210
         		[M + H]+: 339
    216
    Figure US20130072497A1-20130321-C00211
         		[M + H]+: 383
    217
    Figure US20130072497A1-20130321-C00212
         		[M + H]+: 329
    218
    Figure US20130072497A1-20130321-C00213
         		[M + H]+: 315
    219
    Figure US20130072497A1-20130321-C00214
         		[M + H]+: 345
    220
    Figure US20130072497A1-20130321-C00215
         		[M + H]+: 335
    221
    Figure US20130072497A1-20130321-C00216
         		[M + H]+: 321
    222
    Figure US20130072497A1-20130321-C00217
         		[M + H]+: 351
    223
    Figure US20130072497A1-20130321-C00218
         		[M + H]+: 397
    224
    Figure US20130072497A1-20130321-C00219
         		[M + H]+: 343
    225
    Figure US20130072497A1-20130321-C00220
         		[M + H]+: 329
    226
    Figure US20130072497A1-20130321-C00221
         		[M + H]+: 359
    227
    Figure US20130072497A1-20130321-C00222
         		[M + H]+: 400
    228
    Figure US20130072497A1-20130321-C00223
         		[M + H]+: 346
    229
    Figure US20130072497A1-20130321-C00224
         		[M + H]+: 332
    230
    Figure US20130072497A1-20130321-C00225
         		[M + H]+: 362
    231
    Figure US20130072497A1-20130321-C00226
         		[M + H]+: 348
    232
    Figure US20130072497A1-20130321-C00227
         		[M + H]+: 364
    233
    Figure US20130072497A1-20130321-C00228
         		[M + H]+: 360
    234
    Figure US20130072497A1-20130321-C00229
         		[M + H]+: 346
    235
    Figure US20130072497A1-20130321-C00230
         		[M + H]+: 376
    236
    Figure US20130072497A1-20130321-C00231
         		[M + H]+: 371
    237
    Figure US20130072497A1-20130321-C00232
         		[M + H]+: 401
    238
    Figure US20130072497A1-20130321-C00233
         		[M + H]+: 277
    239
    Figure US20130072497A1-20130321-C00234
         		[M + H]+: 302
    240
    Figure US20130072497A1-20130321-C00235
         		[M + H]+: 290
    241
    Figure US20130072497A1-20130321-C00236
         		[M + H]+: 310
    242
    Figure US20130072497A1-20130321-C00237
         		[M + H]+: 308
    243
    Figure US20130072497A1-20130321-C00238
         		[M + H]+: 388
    244
    Figure US20130072497A1-20130321-C00239
         		[M + H]+: 386
    245
    Figure US20130072497A1-20130321-C00240
         		[M + H]+: 307
    246
    Figure US20130072497A1-20130321-C00241
         		[M + H]+: 305
    247
    Figure US20130072497A1-20130321-C00242
         		[M + H]+: 307
    248
    Figure US20130072497A1-20130321-C00243
         		[M + H]+: 332
    249
    Figure US20130072497A1-20130321-C00244
         		[M + H]+: 340
    250
    Figure US20130072497A1-20130321-C00245
         		[M + H]+: 338
    251
    Figure US20130072497A1-20130321-C00246
         		[M + H]+: 358
    252
    Figure US20130072497A1-20130321-C00247
         		[M + H]+: 346
    253
    Figure US20130072497A1-20130321-C00248
         		[M + H]+: 364
    254
    Figure US20130072497A1-20130321-C00249
         		[M + H]+: 294
    255
    Figure US20130072497A1-20130321-C00250
         		[M + H]+: 293
    256
    Figure US20130072497A1-20130321-C00251
         		[M + H]+: 318
    257
    Figure US20130072497A1-20130321-C00252
         		[M + H]+: 324
    258
    Figure US20130072497A1-20130321-C00253
         		[M + H]+: 309
    259
    Figure US20130072497A1-20130321-C00254
         		[M + H]+: 334
    260
    Figure US20130072497A1-20130321-C00255
         		[M + H]+: 322
    261
    Figure US20130072497A1-20130321-C00256
         		[M + H]+: 342
    262
    Figure US20130072497A1-20130321-C00257
         		[M + H]+: 340
    263
    Figure US20130072497A1-20130321-C00258
         		[M + H]+: 347
    264
    Figure US20130072497A1-20130321-C00259
         		[M + H]+: 372
    265
    Figure US20130072497A1-20130321-C00260
         		[M + H]+: 360
    266
    Figure US20130072497A1-20130321-C00261
         		[M + H]+: 380
    267
    Figure US20130072497A1-20130321-C00262
         		[M + H]+: 378
    268
    Figure US20130072497A1-20130321-C00263
         		[M + H]+: 354
    269
    Figure US20130072497A1-20130321-C00264
         		[M + H]+: 379
    270
    Figure US20130072497A1-20130321-C00265
         		[M + H]+: 387
    271
    Figure US20130072497A1-20130321-C00266
         		[M + H]+: 387
    272
    Figure US20130072497A1-20130321-C00267
         		[M + H]+: 353
    273
    Figure US20130072497A1-20130321-C00268
         		[M + H]+: 378
    274
    Figure US20130072497A1-20130321-C00269
         		[M + H]+: 366
    275
    Figure US20130072497A1-20130321-C00270
         		[M + H]+: 386
    276
    Figure US20130072497A1-20130321-C00271
         		[M + H]+: 384
    277
    Figure US20130072497A1-20130321-C00272
         		[M + H]+: 333
    278
    Figure US20130072497A1-20130321-C00273
         		[M + H]+: 358
    279
    Figure US20130072497A1-20130321-C00274
         		[M + H]+: 346
    280
    Figure US20130072497A1-20130321-C00275
         		[M + H]+: 366
    281
    Figure US20130072497A1-20130321-C00276
         		[M + H]+: 364
    282
    Figure US20130072497A1-20130321-C00277
         		[M + H]+: 325
    283
    Figure US20130072497A1-20130321-C00278
         		[M + H]+: 350
    284
    Figure US20130072497A1-20130321-C00279
         		[M + H]+: 338
    285
    Figure US20130072497A1-20130321-C00280
         		[M + H]+: 356
    286
    Figure US20130072497A1-20130321-C00281
         		[M + H]+: 299
    287
    Figure US20130072497A1-20130321-C00282
         		[M + H]+: 324
    288
    Figure US20130072497A1-20130321-C00283
         		[M + H]+: 312
    289
    Figure US20130072497A1-20130321-C00284
         		[M + H]+: 332
    290
    Figure US20130072497A1-20130321-C00285
         		[M + H]+: 330
    291
    Figure US20130072497A1-20130321-C00286
         		[M + H]+: 293
    292
    Figure US20130072497A1-20130321-C00287
         		[M + H]+: 318
    293
    Figure US20130072497A1-20130321-C00288
         		[M + H]+: 326
    294
    Figure US20130072497A1-20130321-C00289
         		[M + H]+: 324
    295
    Figure US20130072497A1-20130321-C00290
         		[M + H]+: 262
    296
    Figure US20130072497A1-20130321-C00291
         		[M + H]+: 325
    297
    Figure US20130072497A1-20130321-C00292
         		[M + H]+: 309
    298
    Figure US20130072497A1-20130321-C00293
         		[M + H]+: 273
    299
    Figure US20130072497A1-20130321-C00294
         		[M + H]+: 340
    300
    Figure US20130072497A1-20130321-C00295
         		[M + H]+: 324
    301
    Figure US20130072497A1-20130321-C00296
         		[M + H]+: 322
    302
    Figure US20130072497A1-20130321-C00297
         		[M + H]+: 270
    303
    Figure US20130072497A1-20130321-C00298
         		[M + H]+: 355
    304
    Figure US20130072497A1-20130321-C00299
         		[M + H]+: 303
    305
    Figure US20130072497A1-20130321-C00300
         		[M + H]+: 381
    306
    Figure US20130072497A1-20130321-C00301
         		[M + H]+: 329
    307
    Figure US20130072497A1-20130321-C00302
         		[M + H]+: 311
    308
    Figure US20130072497A1-20130321-C00303
         		[M + H]+: 295
    309
    Figure US20130072497A1-20130321-C00304
         		[M + H]+: 259
    310
    Figure US20130072497A1-20130321-C00305
         		[M + H]+: 341
    311
    Figure US20130072497A1-20130321-C00306
         		[M + H]+: 325
    312
    Figure US20130072497A1-20130321-C00307
         		[M + H]+: 357
    313
    Figure US20130072497A1-20130321-C00308
         		[M + H]+: 341
    314
    Figure US20130072497A1-20130321-C00309
         		[M + H]+: 395
    315
    Figure US20130072497A1-20130321-C00310
         		[M + H]+: 379
    316
    Figure US20130072497A1-20130321-C00311
         		[M + H]+: 343
    317
    Figure US20130072497A1-20130321-C00312
         		[M + H]+: 402
    318
    Figure US20130072497A1-20130321-C00313
         		[M + H]+: 350
    319
    Figure US20130072497A1-20130321-C00314
         		[M + H]+: 401
    320
    Figure US20130072497A1-20130321-C00315
         		[M + H]+: 385
    321
    Figure US20130072497A1-20130321-C00316
         		[M + H]+: 349
    322
    Figure US20130072497A1-20130321-C00317
         		[M + H]+: 381
    323
    Figure US20130072497A1-20130321-C00318
         		[M + H]+: 365
    324
    Figure US20130072497A1-20130321-C00319
         		[M + H]+: 329
    325
    Figure US20130072497A1-20130321-C00320
         		[M + H]+: 321
    326
    Figure US20130072497A1-20130321-C00321
         		[M + H]+: 347
    327
    Figure US20130072497A1-20130321-C00322
         		[M + H]+: 331
    328
    Figure US20130072497A1-20130321-C00323
         		[M + H]+: 295
    329
    Figure US20130072497A1-20130321-C00324
         		[M + H]+: 34
    330
    Figure US20130072497A1-20130321-C00325
         		[M + H]+: 325
    331
    Figure US20130072497A1-20130321-C00326
         		[M + H]+: 289
    332
    Figure US20130072497A1-20130321-C00327
         		[M + H]+: 421
    333
    Figure US20130072497A1-20130321-C00328
         		[M + H]+: 373
    334
    Figure US20130072497A1-20130321-C00329
         		[M + H]+: 422
    • Example VIII Insecticidal Testing
  • The compounds identified in TABLE 2 were prepared using the procedures illustrated in the previous examples and these compounds were tested against beet armyworm, mosquito, fruit fly, and cotton aphid using protocols described after.
  • TABLE 2
    Compound # LAPHEG AEDSAE DROSME CA 200
    17 C C B C
    34 C C C D
    38 C C C A
    44 C C C C
    50 C C C A
    80 B C C B
    81 C C C A
    86 C B C A
    87 C C C B
    88 C C C A
    90 C C B A
    91 C C B C
    92 C C B C
    93 C C B C
    95 C C B A
    96 B C C A
    99 C C C A
    100 C C B A
    101 C C C A
    102 C C C A
    103 C C C A
    104 C C A A
    105 C C C A
    106 C C C A
    107 C C A A
    108 C C C A
    126 C C C A
    139 B C C D
    146 C C C D
    156 C C C A
    159 C C C D
    160 C C C C
    162 C C B D
    192 C C C D
    303 C C B D
    321 C C C D
    333 C C A A
    LAPHEG refers to % mortality at 4000 μg/ml against beet armyworm on artificial diet,
    AEDSAE refers to % mortality at 20 μg/ml against mosquito larvae
    DROSME refers to % mortality at 4000 μg/m1 against adult fruit fly on artificial diet
    CA 200 refers to % control at 200 ppm against cotton aphid in foliar spray tests.
  • In each case of Table 2 the rating scale is as follows:
  • % Mortality Rating
    50-100 A
    26-49  B
    1-25 C
    Not tested D
    • Insecticidal Tests
  • Compounds were evaluated on mosquito (Aedes aegypti) larvae, beet armyworm (Spodoptera exigua) larvae, fruit fly (Drosophila melanogaster) adults and cotton aphid (Aphis gossypi). Newly hatched mosquito larvae (about 50 larvae/well) in 96-well microtiter plates in 230 ul of water containing powdered liver/yeast extract (1 gr/100 ml) were treated with 20 ppm solution of the test compound. Following treatment the plates were covered with a lid and mortality was determined three days after treatment. Beet armyworm eggs (about 5 per well) were placed on artificial diet (in a 96-well microtiter plate) treated with a 4000 ppm solution of a test compound in combination with piperonyl butoxide (in approximate ratio of 1:4). After infestation, the plates were covered with a lid and mortality was determined seven days following treatment. Five-day old fruit fly adults (about 5/well) were placed in deep-well microtiter plates containing 250 ul/well of a 2% agar-10% sucrose mixture that had been treated with a 4000 ppm solution of a test compound. Following infestation, the plates were covered with a lid and mortality was determined three days after treatment. Treatments for the mosquito and armyworm were replicated six times each, that of the fruit fly three times each.
  • Squash with fully expanded cotyledon leaves were trimmed to one cotyledon per plant and infested with cotton aphid (wingless adult and nymph) 1 day prior to chemical application. Each plant is examined before chemical application to ensure proper infestation (ca. 30-70 aphids per plant). Compounds (3 mg) were dissolved in 3 mL of acetone:methanol (50:50) solvent, forming stock solutions of 1000 ppm. The stock solutions were then diluted with 0.025% Tween 20 (in H2O) to make 200 spray solutions. A hand-held Devilbiss sprayer was used to apply the spray solutions until runoff to both sides of the squash cotyledon leaves. Four plants (4 replications) were used for each concentration of each compound. Reference plants (solvent check) were sprayed with 0.025% Tween 20 only. Treated plants were held in a holding room for 3 days at approximately 23° C. and 40% RH before the number of live aphids on each plant was recorded. Insecticidal activity was measured by Corrected % Control using Abbott's correction formula and presented in TABLE 2:

  • Corrected % Control=100*(X−Y)/X
      • where X=No. of live aphids on solvent check plants
        • Y=No. of live aphids on treated plants
    Example IX Fungicidal Testing
  • The compounds identified in Table 4 were prepared using the procedures illustrated in the previous examples and these compounds were tested against wheat glume blotch and wheat leaf blotch using the protocols described herein.
    • Fungicidal Test for LEPTNO
  • Glume Blotch of Wheat (causal agent Leptosphaeria nodorum=Stagnospora nodorum; Bayer code LEPTNO): Wheat plants (variety Yuma) were grown from seed in a 50 pasteurized soil/50 percent soil-less mix until the seedlings had a fully expanded first leaf. Each pot contained 3-20 seedlings. These plants were sprayed until wet with the formulated test compound at a rate of 25 ppm. On the following day, the leaves were inoculated with an aqueous spore suspension of Leptosphaeria nodorum and the plants were kept in high humidity (one day in a dark dew chamber followed by four to seven days in a lighted dew chamber) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse until disease developed on untreated control plants.
    • Fungicidal Test for SEPTTR
  • Speckled Leaf Blotch of Wheat (Mycosphaerella graminicola=Septoria tritici; Bayer code SEPTTR): Wheat plants (variety Monon) were grown from seed in a greenhouse in 50% pasteurized soil/50% soil-less mix until the first true leaf was fully expanded, with 3-8 seedlings per pot. These plants were sprayed until wet with the formulated test compound at a rate of 25 ppm. On the following day, the leaves were inoculated with an aqueous spore suspension of Septoria tritici and the plants were kept in high humidity (one day in a dark dew chamber followed by four to seven days in a lighted dew chamber) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse until disease developed on untreated control plants.
  • TABLE 3
    Compound # LEPTNO SEPTTR
    80 A A
    81 A A
    88 C A
    92 A C
    93 C A
    109 C A
    110 C A
    111 A A
    112 C A
    114 C A
    118 A A
    119 A B
    128 A A
    187 A A
    234 A C
    236 A C
    LETPNO refers to in vitro control one day protectant at 25 ppm on wheat glume blotch
    SEPTTR refers to in vitro control one day protectant at 25 ppm on wheat leaf blotch
  • In each case of TABLE 3 the rating scale is as follows:
  • % Control Rating
    50-100 A
    26-49  B
    1-25 C

Claims (5)

We claim:
1. A composition comprising a compound of the Formula (I)
Figure US20130072497A1-20130321-C00330
wherein
X and Y are each independently selected from the group consisting of a direct bond, alkyl, carbonyl, carbonylalkyl, carbonylalkylether, carboxylalkyl, alkylcarbonyl, alkylcarboxyl, and alkylether;
with the proviso that both X and Y cannot be a direct bond; and when either X or Y is a direct bond, then the R1 or R2 associated with that bond is not phenyl or optionally substituted phenyl; and
R1 and R2 are each independently selected from the group consisting of:
alkyl;
aryl, optionally substituted with cyano, alkoxy, halogen, alkylhalo, alkoxyhalo, carboxylalkyl, carbonylalkyl, benzyloxy, nitro, benzoyl, phenyl, carboxamido, or heteroaryl;
heteroaryl, optionally substituted with aryl, heteroaryl, alkyl, halogen, alkylhalo, alkoxy, cycloalkyl or cyano;
cycloalkyl, optionally substituted with alkyl or halogen; and
a heterocyclic ring, optionally substituted with alkyl in a mixture with one or more fungicides or insecticides or both.
2. A composition according to claim one wherein each of X and Y of said compound of Formula (I) are independently selected from the group consisting of a direct bond, alkyl, and carbonyl.
3. A composition according to claim one wherein each of R1 and R2 of said compound of Formula (I) are independently selected from the group consisting of:
alkyl;
aryl, optionally substituted with cyano, alkoxy, halogen, alkylhalo, alkoxyhalo, carboxylalkyl, carbonylalkyl, benzyloxy, nitro, benzoyl, phenyl, carboxamido, or heteroaryl; and
heteroaryl, optionally substituted with aryl, heteroaryl, alkyl, halogen, alkylhalo, alkoxy, cycloalkyl or cyano.
4. A method of controlling insects comprising applying to a locus where control is desired an insect-inactivating amount of a composition of claim 1.
5. A composition according to claim 1 wherein said compound of Formula (I) is one of the compounds 1 through 334.
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