US20120035706A1 - Blood perfusion device delivery system - Google Patents

Blood perfusion device delivery system Download PDF

Info

Publication number
US20120035706A1
US20120035706A1 US13/197,074 US201113197074A US2012035706A1 US 20120035706 A1 US20120035706 A1 US 20120035706A1 US 201113197074 A US201113197074 A US 201113197074A US 2012035706 A1 US2012035706 A1 US 2012035706A1
Authority
US
United States
Prior art keywords
sleeve
prosthesis
retraction
actuation member
vessel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/197,074
Other languages
English (en)
Inventor
Ram H. Paul, Jr.
Jessica L. Burke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Medical Technologies LLC
Original Assignee
Cook Medical Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Medical Technologies LLC filed Critical Cook Medical Technologies LLC
Priority to US13/197,074 priority Critical patent/US20120035706A1/en
Assigned to COOK INCORPORATED reassignment COOK INCORPORATED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PAUL, RAM H., JR., BURKE, JESSICA L.
Assigned to COOK MEDICAL TECHNOLOGIES LLC reassignment COOK MEDICAL TECHNOLOGIES LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: COOK INCORPORATED
Publication of US20120035706A1 publication Critical patent/US20120035706A1/en
Priority to US14/324,878 priority patent/US9918824B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1132—End-to-end connections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
    • A61F2002/8483—Barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0036—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in thickness
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0037—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in height or in length

Definitions

  • the preferred embodiments described herein relate generally to medical device delivery systems for open surgical repair of body structures that define body lumens. More particularly, they relate to medical device delivery systems for repairing damaged body structures and gaining hemostasis or fluid stability during emergency open surgical medical procedures.
  • Significant damage to a body vessel may expose a patient to deleterious conditions such as the loss of a limb, loss of function of a limb, increased risk of stroke, impairment of neurological functions, and compartment syndrome, among others.
  • Particularly severe cases of vascular injury and blood loss may even result in death. In such severe situations, the immediate goal is to obtain hemostasis while maintaining perfusion of adequate blood flow to critical organs, such as the brain, liver, kidneys, and heart.
  • Examples of treatment that are commonly performed by trauma physicians to treat body vessel injuries include the clamping of the vessel with a hemostat, the use of a balloon tamponade, the ligation of the damaged vessel at or near the site of injury, or the insertion of one or more temporary shunts.
  • conventional surgical repair is generally difficult with such actively bleeding, moribund patients.
  • the trauma physician will simply insert a temporary shunt (such as a Pruitt-Inahara Shunt) into the vessel.
  • a temporary shunt such as a Pruitt-Inahara Shunt
  • shunts are generally placed as a temporary measure to restore blood flow and stop excessive blood loss, the shunt is typically removed when the patient has stabilized (generally a few days later) by a specialized vascular surgeon. After removal, the vascular surgeon will replace the shunt with a vascular graft, such as a fabric graft that is sewn into place. With respect to ligation, ligation of the damaged blood vessel may result in muscle necrosis, loss of muscle function, or a potential limb loss or death.
  • sutures to affix damaged tissue portions surrounding fittings that have been deployed with the vessel, which requires the trauma physician to take time to tie the sutures properly.
  • sutures can be tied in relatively rapid fashion, any step in a repair process that occupies physician time in an emergency situation is potentially problematic.
  • the use of sutures to affix the vessel to the fitting compresses the tissue of the vessel against the fitting. Compression of tissue may increase the risk of necrosis of the portion of the vessel tissue on the side of the suture remote from the blood supply. When present, necrosis of this portion of the vessel tissue may result in the tissue separating at the point of the sutures. In this event, the connection between the vessel and the fitting may eventually become weakened and subject to failure.
  • the device may disengage from the vessel. Therefore, efforts continue to develop techniques that reduce the physician time required for such techniques, so that this time can be spent on other potentially life-saving measures, and the blood flow is more quickly restored and damage caused by lack of blood flow is minimized
  • a delivery device for delivering a prosthesis for use in repair of an injured body vessel, such as an artery or a vein, (and in particular a transected vessel) during emergency open surgery. It would be desirable if such delivery device was easy for a trauma physician to use, and can rapidly introduce a prosthesis into a body vessel, thereby providing a conduit for blood or fluid within the injured body vessel.
  • a delivery system can include a sleeve and first and second retraction members.
  • the sleeve can be configured to retain segments of a prosthesis in a compressed configuration.
  • the sleeve can have a first outer segment and a second outer segment associated with a first outer end and a second outer end of the prosthesis, respectively.
  • the first retraction member can be coupled to the first outer segment of the sleeve
  • the second retraction member can be coupled to the second outer segment of the sleeve.
  • the first and second outer segments of the sleeve are removed from the corresponding outer ends of the prosthesis. Such removal allows for the expansion of the outer ends of the prosthesis in an outside-in direction.
  • the delivery system can include a handle and an actuation member movably attached to the handle.
  • An assembly can be disposed at a distal end of the handle.
  • the assembly can include a sleeve configured to retain segments of a prosthesis in a compressed configuration.
  • the sleeve can have a first outer segment and a second outer segment that are associated with a first outer end and a second outer end of the prosthesis, respectively.
  • a first retraction member can be coupled between the first outer segment of the sleeve and the actuation member, and a second retraction member can be coupled between the second outer segment of the sleeve and the actuation member.
  • the handle may include a guiding member to redirect the retraction members from a direction generally along the longitudinal axis to a direction different from the longitudinal axis, such as along the translational axis of the actuation member, which is generally perpendicular to the longitudinal axis.
  • the actuation member may include a retaining member configured to removably attach with each of the retraction members.
  • a method of open surgical repair of a body vessel can include one or more of the following steps, including inserting a first outer end of a prosthesis in a first vessel portion of a body vessel.
  • the first outer end of the prosthesis can be retained in a compressed configuration by a sleeve portion.
  • a second outer end of the prosthesis can be inserted in a second vessel portion.
  • the second outer end of the prosthesis can be retained in a compressed configuration by a sleeve portion.
  • the sleeve portions can be composed of a single sleeve or multiple sleeves. Sleeve portions can be removed from the respective first and second outer ends of the prosthesis.
  • the first and second outer ends of the prosthesis can be allowed to move to an expanded configuration for engagement with the corresponding vessel portion of the body vessel.
  • the sleeve portions can be removed with application of an activation agent configured to rapidly weaken or to dissolve the sleeve portions.
  • FIG. 1A is an elevation view of an example delivery system having a prosthesis retained in a compressed configuration by a removable sleeve.
  • FIG. 1B is an end view of the system of FIG. 1A .
  • FIGS. 2A-2B are elevation views of the system FIG. 1A , depicting operation of the system for removal of the sleeve from the prosthesis.
  • FIG. 3A is a perspective view of an example delivery system, and in particular, a system for use with the delivery system of FIG. 1A .
  • FIG. 3B is a cross-sectional view of the system of FIG. 3A taken along line 3 B- 3 B.
  • FIG. 3C is a perspective view of a distal end of the system of FIG. 3A , depicting a guiding element.
  • FIG. 3D is a cross-sectional view of the system of FIG. 3C taken along line 3 D- 3 D.
  • FIG. 4A is a perspective view of a partial distal end of the system of FIG. 3A , depicting a handle body with a sharp edge.
  • FIG. 4B is an end view of the distal end of the system of FIG. 4A , depicting a sharp edge of the handle body with a distal tip in dashed lines.
  • FIGS. 5A-5E illustrate a method of open surgical repair of a body vessel with a delivery system deploying a prosthesis.
  • FIG. 6A is an elevation view of another delivery system for deploying a prosthesis, depicting a removable sleeve that can dissolve.
  • FIGS. 6B-6E are partial elevation cross-sectional views of a damaged body vessel, depicting alternative method steps of deploying a prosthesis using the system of FIG. 6A .
  • distal and distal shall denote a position, direction, or orientation that is generally towards, or in the direction of, the patient when the device is in use.
  • proximal and proximally shall denote a position, direction, or orientation that is generally away from the patient, or closer to the operator, during use of the device. It is understood that like-referenced numerals are used throughout the Figures to designate similar components.
  • the delivery system described herein can deploy a prosthesis that is useful for repair of body structures that define lumens, ducts, or passageways of the body, with the term “body vessel” used in the specification to describe theses structures in general, during emergency open surgical repair.
  • the prosthesis can be particularly useful for repair of a lacerated or transected body vessel during emergency open surgery, and particularly, to obtain hemostasis or fluid stability while maintaining blood perfusion or fluid flow. While some prosthetic devices are only implanted temporarily for treatment, the prosthesis can be implanted permanently thereby obviating the need for further surgical intervention and repair.
  • blood vessels are of two types, namely arteries and veins.
  • arteries are elastic vessels that carry oxygenated blood away from the heart
  • veins are elastic vessels that transport blood to the heart and that then transport blood to the lungs for oxygenation.
  • the walls of both arteries and veins generally consist of three layers or tunics.
  • the inner layer is referred to as the tunica intima, which is composed of endothelium and delicate collagenous tissue.
  • the middle layer is referred to as the tunica media, which is composed of typically a muscular layer, and consists of smooth muscle and elastic fibers.
  • the outer layer is referred to as the tunica adventitia, which is the outer covering of the vessel, and is composed of connective tissue, collagen, and elastic fibers.
  • the tunic adventitia includes small vessels, referred to as vasa vasorum, which supply nutrients to the tissue.
  • the prosthesis controllably interacts with the tunica intima, basement membrane, and tunica media, and avoids interaction with the tunica adventitia to not disrupt the vasa vasorum residing in the tunica adventitia.
  • the prosthesis can be secured in a rapid manner without the use of a ligature or suture placed around the vessel.
  • FIGS. 1A-1B depict one example delivery system 10 including a prosthesis 15 (shown in dashed lines) retained in a radially compressed configuration by a removable tubular sleeve 30 .
  • the removable sleeve 30 may be fitted at least partially over the first and/or second outer ends 18 , 19 of the prosthesis 15 to selectively retain the outer ends in the compressed configuration for insertion into an end opening of the a vessel.
  • the removable sleeve 30 may be composed of a single sleeve configured to retain the entire prosthesis from the first end 18 to the second end 19 of the prosthesis 15 .
  • the removable sleeve 30 may include two discrete sleeve portions (not shown).
  • the removable sleeve includes a first sleeve portion retaining a first outer segment of the prosthesis 15 associated with the first outer end 18 , and a second sleeve portion retaining a second outer segment of the prosthesis 15 associated with the second outer end 19 , leaving an intermediate segment between the first and second outer segments unretained by the removable sleeve.
  • the removable sleeve 30 can be everted or folded at a point of eversion 33 A, 33 B proximate the outer ends 18 , 19 of the prosthesis 15 and be directed toward a middle 34 of the prosthesis.
  • This arrangement can form a radially inner layer 36 and a radially outer layer 38 of the sleeve 30 and allows the ends of the outer layer to gather toward the prosthesis middle 34 .
  • the outer layer 38 and the inner layer 36 are two separate tubular members that are coupled to one another by an attachment mechanism, such as by adhesives, soldering, welding, sewing or other common attachment mechanisms.
  • the inner layer 36 can directly contact the prosthesis 15 to extend along at least partially a segment of the prosthesis.
  • the outer layer 38 can extend from the outer end of the inner layer 36 to a more intermediate portion of the inner layer.
  • the inner and outer layers may slidably interact with one another during retraction of the outer layer ends.
  • a lubricious coating may be applied to suitable portions of the layers to facilitate their interaction.
  • the lubricious coating can be a fluoropolymer of the type commonly used to impart lubricity to a medical device, and most preferably, polytetrafluoroethylene (PTFE).
  • the sleeve 30 may be pre-split in order to facilitate mechanical removal of the sleeve from the prosthesis.
  • any number of splits 45 can be pre-formed in the outer layer from the outer layer end toward an intermediate portion proximate the eversion points 33 A, 33 B.
  • Having a solid outer layer material between the eversion point and the beginning of the split forms a sold ring 47 of material around the ends of the prosthesis, which preferably overlays the anchoring members of the prosthesis.
  • the solid ring 47 can comprise the outer layer and the inner layer together forming a double layer of materials to enhance the retention of the outer ends of the prosthesis to the compressed configuration.
  • the outer layer and its ends can be manipulated and retracted by the end user to remove the sleeve from the prosthesis.
  • the system can include at least two retraction members associated with the outer ends of the prosthesis.
  • the first and second retraction members can be independently retractable.
  • FIG. 1A shows four splits that form the four outer layer ends, although two or three or more outer layer ends may be formed.
  • the four outer layer ends can define first and third retraction members 46 A, 46 C associated with the first outer end 18 of the prosthesis 15 and second and fourth retraction members 46 B, 46 D associated with the second outer end 19 of the prosthesis 15 .
  • the ends of the retraction members can be enlarged or have an enlarged knob 48 attached thereto to facilitate gripping and manipulation of the sleeve 30 during removal from the prosthesis.
  • the retraction member is operable for peeling and/or splitting the sleeve 30 from the respective outer ends 18 , 19 toward the middle 34 of the prosthesis 15 to allow for expansion thereof
  • the retraction member and the removable sleeve are formed integrally from a single tubular piece of sleeve material.
  • the outer end of the tubular sleeve is everted along the prosthesis so that the everted portions form the retraction member.
  • the retraction member may be a discrete member from the sleeve.
  • the retraction member may be composed of sleeve material and/or a tension member, such as a wire or a filament of biocompatible metal or plastic.
  • the discrete retraction member can have a first end attached to the outer end of the removable sleeve and a second end that is accessible by the end user.
  • the prosthesis 15 can include a generally tubular graft body and/or one or more anchoring members 49 and/or supporting members together defining a fluid passageway.
  • the prosthesis 15 is movable between the radially compressed, delivery configuration and the radially expanded, deployed configuration.
  • the prosthesis can be balloon expandable; however, it is preferred that the prosthesis is self-expandable.
  • the anchoring members and/or supporting members can be attached to the graft body by sutures sewn therein, wire, staples, clips, bonding agents, or other methods that may be used to achieve a secure attachment to the graft body.
  • the prosthesis has a size and shape suitable for at least partial placement within a body vessel, such as an artery or vein, and most particularly, for placement at the site of a vascular trauma.
  • the prosthesis may be easily manipulated during delivery to a body vessel such as a transected artery or vein during emergency surgery, and particularly, to obtain hemostasis while maintaining blood perfusion.
  • the anchoring member and/or supporting member can be any stent pattern known to one skilled in the art.
  • the anchoring member and/or supporting member can be formed of a biocompatible metal, such as stainless steel (e.g., 316L SS), titanium, tantalum, nitinol or other shape memory materials, or a high-strength polymer.
  • the anchoring member 49 can provide vessel fixation, while preferably avoiding adverse conditions associated with disturbing the vasa vasorum and/or pressure induced necrosis of the medium muscular arteries of the type that may result from tying ligatures circumferentially around a connector or a vascular conduit.
  • the anchoring member 49 can include various shaped member structures, including barbs, fibers, bristles, or outer protruding and penetrable media.
  • the graft body can be formed from conventional materials well known in the medical arts.
  • the graft body may comprise an expanded polytetrafluoroethylene (ePTFE), polytetrafluoroethylene, silicone, polyurethane, polyamide (nylon), as well as other flexible biocompatible materials.
  • the graft body can also be formed from known fabric graft materials such as woven polyester (e.g. DACRON®), polyetherurethanes such as THORALON® from Thoratec Corporation (Pleasanton, Calif.), polyethylene such as an ultra-high molecular weight polyethylene (UHMwPE), commercially available as DYNEEMA®.
  • UHMwPE ultra-high molecular weight polyethylene
  • the graft body may also include a bioremodelable material, such as reconstituted or naturally-derived collagenous materials, extracellular matrix material (ECM), submucosa, renal capsule membrane, dermal collagen, dura mater, pericardium, fascia lata, serosa, peritoneum or basement membrane layers, intestinal submucosa, including small intestinal submucosa (SIS), stomach submucosa, urinary bladder submucosa, and uterine submucosa.
  • ECM extracellular matrix material
  • submucosa renal capsule membrane
  • dermal collagen dura mater
  • pericardium fascia lata
  • serosa serosa
  • intestinal submucosa including small intestinal submucosa (SIS), stomach submucosa, urinary bladder submucosa, and uterine submucosa.
  • SIS small intestinal submucosa
  • SIS small intestinal
  • Portions of the prosthesis can also include a coating of one or more therapeutic agents along a portion of the stent structure and/or the graft body.
  • Therapeutic agents for use as biocompatible coatings are well known in the art.
  • suitable bio-active agents that may be applied to the vascular conduit include thrombo-resistant agents, antibiotic agents, anti-tumor agents, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-mitotic agents, anti-inflammatory agents, angiostatin agents, endostatin agents, cell cycle regulating agents, genetic agents, including hormones such as estrogen, their homologs, derivatives, fragments, pharmaceutical salts and combinations thereof.
  • suitable bio-active agents include thrombo-resistant agents, antibiotic agents, anti-tumor agents, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-mitotic agents, anti-inflammatory agents, angiostatin agents, endostatin agents, cell cycle regulating agents, genetic agents, including hormones such as estrogen, their homologs, derivatives,
  • the bioactive agent can be incorporated into, or otherwise applied to, portions of the vascular conduit by any suitable method that permits adequate retention of the agent material and the effectiveness thereof for its intended purpose.
  • the device has been described in connection with its primary intended use for repair of vascular trauma, those skilled in the art will appreciate that the device may also be used to repair other traumatic conditions. Non-limiting examples of such conditions include aneurysms, such as abdominal aorta aneurysms, and surgery for tumor removal.
  • the sleeve 30 can be made of any material that is biocompatible and suitable to retain the prosthesis in the radially compressed configured and yet still capable of being peeled from the prosthesis and/or split. It is desirable that the sleeve is made from materials that are thin as possible to reduce the overall delivery profile of the system.
  • the sleeve can be extruded from a biocompatible polymer material.
  • the sleeve can be formed of at least one layer such as a polyether block amide, nylon, polyurethane, polytetrafluoroethylene (PTFE), FEP, or any combination thereof In one example, the sleeve can be removed from the prosthesis without splitting.
  • the sleeve can be configured to be separated, preferably longitudinally, along a relatively predictable path.
  • the material of the sleeve is configured to be split or cut into two or more portions by movement of the sleeve alone relative to the prosthesis and/or movement of the sleeve against a handle portion, thereby opening a fissure along the length that permits its removal from around the prosthesis situated therein.
  • a predetermined split line may be formed in the sleeve through which the tear or split progresses due to properties of, and/or features incorporated into the material. When present, the predetermined split line can withstand being subjected to a curve to the degree required by the particular application without kinking or premature separation.
  • the sleeve can comprise a splittable polymer such as molecularly oriented, non-isotropic PTFE that is used to make the PEEL-AWAY® Introducer Sheath, which is commercially provided by Cook Medical Inc. (Bloomington, Ind.).
  • a splittable polymer such as molecularly oriented, non-isotropic PTFE that is used to make the PEEL-AWAY® Introducer Sheath, which is commercially provided by Cook Medical Inc. (Bloomington, Ind.).
  • Cook Medical Inc. Bloomington, Ind.
  • the sleeve can include one or more preweakened features, such as a score line, perforations, or reduced wall thickness regions, extending longitudinally along the length of the sleeve.
  • FIGS. 2A-2B show an example method of removing the sleeve 30 from the prosthesis 15 in order to allow the prosthesis to radially expand.
  • the delivery system 10 can be reoriented such that the retraction members 46 A- 46 D are gathered toward the prosthesis middle 34 at a single side 50 of the system 10 .
  • This arrangement places some of the splits 45 on another side 52 , opposite the side 50 .
  • a trauma pathway is formed in the body in order to gain access to the desired body vessel.
  • One or both ends 18 , 19 of the prosthesis retained by the sleeve can be inserted within the body vessel, as described below. According to FIG.
  • the retraction members 46 A- 46 D can be moved relative to the side 52 , in a radial direction represented by arrow 54 within the trauma pathway, to cause a portion of the sleeve 30 to further peel or separate the splits 45 (i.e., increase the length of the splits).
  • This action removes a portion of the sleeve 30 away from the outer ends 18 , 19 from an outside-in direction in order to allow for radial expansion of the prosthesis 15 at its ends 18 , 19 , where the anchor members 49 can engage the body vessel wall.
  • the sleeve 30 can be first removed along the surface of the prosthesis in the outside-in direction along the outer surface of the prosthesis initially before being moved in the radial outward direction 54 .
  • the retraction members can be moved relative to the side 52 until the sleeve 30 is entirely removed from the prosthesis.
  • a force or a structure 56 can be placed approximately at the prosthesis middle 34 for leverage as the sleeve is being removed.
  • the retraction members are pulled in the retraction direction until the sleeve is entirely removed from the prosthesis.
  • the expansion force of the prosthesis may facilitate the peeling and/or splitting of the sleeve during the removal process.
  • FIG. 3A depicts a delivery tool 100 that may be utilized with the system 10 , as will be further explained, to define another delivery system 200 , as shown, e.g., in FIG. 5B .
  • the tool 100 can include a handle 101 having a proximal end 102 and a distal end 104 .
  • the proximal end 102 can be shaped and sized to fit within a palm of the end user.
  • the distal end 104 can be shaped and sized to engage the system 10 to define the structure 56 in FIG. 2B , e.g., at the prosthesis middle 34 .
  • the distal end 104 may include a contoured tip 106 shaped to fit around the rounded surface of the prosthesis.
  • the tip 106 can have a concave curvature or a saddle shape that is sized to receive the curvature of a portion of the system 10 , which includes the sleeve and the prosthesis.
  • An actuation member 108 such as, e.g., a lever, can be attached to the system handle 101 , which can be moved relative to the handle between a first position and a second position along a translation axis TA.
  • the actuation member 108 may be configured to move and cause simultaneous or sequential expansion of the outer ends of the prosthesis.
  • the actuation members 108 is in the form of a lever shown slidably attached within a slot 109 that is formed approximately through the center of the handle 101 .
  • the actuation member 108 may be configured to allow for simultaneous expansion of the outer ends of the prosthesis.
  • the actuation member may be configured to allow for sequential expansion of the outer ends of the prosthesis, such as, e.g., having a movable left portion associated with the first outer end and a movable right portion associated with the second outer end.
  • the slot 109 may be an open slot extending entirely through the handle so that access to the open slot is available from opposite sides of the handle.
  • the slot 109 may be a closed slot or a groove formed in opposite sides of the handle, which are not in communication with one another.
  • the slot 109 can provide a guiding channel for the movable actuation member and its ends may function as physical stops to define the first and second positions of the actuation member 108 .
  • the slot 109 can be dimensioned so that, when the actuation member 108 is at the first position (e.g., at the distal end 110 of the slot 109 ), the sleeve 30 can retain the prosthesis in the radially compressed configuration.
  • the actuation member 108 reaches the second position (e.g., the proximal end 111 of the slot 109 )
  • the sleeve 30 can be removed sufficiently to allow at least the outer ends of the prosthesis to expand to the radially expanded configuration.
  • the sleeve 30 can be removed entirely from the prosthesis.
  • the lever 108 may include contoured portions for better receiving the fingers of the end user.
  • the sleeve 30 can be coupled to the actuation member 108 in such a manner such that movement of the actuation member can change the positioning of the sleeve relative to the prosthesis.
  • the sleeve portions such as, e.g., the retraction members, can be attached in a secured relationship with the actuation member by a variety of attachment mechanisms, such as clamps, mechanical fasteners, adhesives, welding, soldering, sewing, or attachment mechanisms.
  • the coupling can enhance the removal of the sleeve from the prosthesis.
  • Each of the retraction members can be coupled to the first outer segment of the sleeve at a first attachment point and to the actuation member at a second attachment point that is closer in proximity to the middle of the prosthesis.
  • the sleeve 30 can be removably attached to the actuation member 108 , e.g., by threaded engagement, removable clamps, or mechanical fasteners.
  • the actuation member 108 can be configured to receive the ends of the retraction members for removable attachment therewith.
  • the actuation member 108 may include a retaining member 120 .
  • the retaining member 120 can be attached to the actuation member 108 , e.g., to opposite surfaces 121 of the actuation member.
  • the member 120 can include a notch 122 configured to receive a portion of the retraction members.
  • a front opening 124 may be formed in the retaining member that is in communication with the notch 122 to allow the retraction member to pass selectively therethrough.
  • the retaining member 120 can be a variety of shapes.
  • the retaining member 120 includes a pair of “L”-shaped elements, having a first leg extending out from the surface 121 of the actuation member 108 and a second leg extending toward the middle.
  • the retaining member 120 can be positioned relative to one another such that the ends of the second legs are spaced from one another to define the front opening 124 .
  • the notch 122 and/or the front opening 124 are sized to receive the ends of the retraction members, but sized smaller than the enlarged ends. This arrangement can facilitate the retention of the sleeve and/or the retraction member by the retaining member when the actuation member is moved relative to the prosthesis.
  • the retaining member can cooperatively confine the retraction member into the notch such that the retraction member is prevented from falling out in the direction of the first leg and/or the direction of the second leg.
  • the retaining member 120 can allow for easy attachment and removal of the ends of the retraction members so that the delivery tool 100 can be used and/or reused for a variety of prosthesis sizes.
  • FIG. 3B illustrates that the actuation member 108 may be configured to surround the handle 101 .
  • the actuation member 108 may have a channel 130 formed therein along the translational axis and sized to receive the handle 101 .
  • the retaining member 120 can be on either side or both sides of the actuation member 108 .
  • a connecting member 132 coupling both sides of the actuation member 108 can be extended through the slot 109 .
  • the connecting member 132 can traverse within the slot 109 when the actuation member is being moved between the first position and the second position.
  • FIGS. 3C-3D illustrate that the tool 100 may include a guiding element 135 that is configured to facilitate the transition of the retraction member from a horizontal direction in the figures, such as along the longitudinal axis of the prosthesis, to a different direction, such as along the translational axis or vertical direction in the figures.
  • the guiding element 135 can be extended away from the surface of the handle 101 , and can include a leg 136 A at which the retraction member is redirected to the different direction.
  • the guiding element 135 may provide a leverage point where as the end user pulls in a first direction from the trauma pathway, the sleeve peels and/or splits along the horizontal direction generally perpendicular to the pulling direction.
  • the guiding element 135 can be a variety of shapes, such as an elongate body or “L”-shaped, having the leg 136 A extending out from the surface 137 of the handle 101 and a second leg 136 B extending toward the middle to define an opening 138 .
  • the opening 138 can be configured to allow the retraction member to pass therethrough in order to lead to the retaining member 120 . It is preferable that the opening 138 be sized to allow for movement of the retraction member therein.
  • the guiding element can confine the retraction member into the opening such that the retraction member is prevented from falling out in the direction of the first leg and the direction of the second leg.
  • the first legs 136 A of a pair of guiding element may be spaced from one another in order to confine the removal of the retraction member and the sleeve to a cross-sectional area less than the area of the laceration or the size of the gap between the vessel portions. This arrangement permits the retraction member and the sleeve to be removed without contacting or rubbing against the edges of the laceration or the body vessel portions to avoid further damage to the vessel.
  • FIGS. 4A-4B show an another example handle 101 , where the distal end of the handle may be configured to facilitate the splitting of the sleeve along the split.
  • the surfaces defining the distal end 104 can converge toward one another to form a first sharp edge 140 along the distal end.
  • the lateral surfaces may converge toward one another to form a second sharp edge 142 .
  • the first and second sharp edges can form a continuous sharp edge. It can be appreciated by those skilled in the art that the edges are sharp enough to facilitate splitting of the sleeve, but not sharp to damage body tissue.
  • FIGS. 5A-5E show the operation of the tool 100 with the system 10 loaded at its distal end to define the delivery system 200 .
  • FIG. 5A depicts an example body vessel 220 , such as one found in the leg of a patient.
  • the body vessel 220 has previously been subjected to a traumatic episode, resulting in a portion 222 of body vessel 220 being torn away or otherwise severely damaged.
  • Pre-surgery preparation has been applied to the leg and a trauma pathway may be formed therein in order to gain access to the body vessel and the damaged portion thereof
  • the body vessel 220 can be cut or transected by the clinician into two portions 220 A, 220 B, as shown in FIG. 5B .
  • the lacerated portion 222 remains without requiring transection and the opening formed thereby can be used for insertion of the prosthesis.
  • the transection may be at the damaged portion 222 of the blood vessel 220 or as far away as necessary from the damaged portion to remove unhealthy portions of the body vessel or unrepairable portions of the body vessel.
  • Sutures can be attached to the end openings 225 of the body vessel portions 220 A, 220 B to keep them fixed in place and opened to facilitate insertion of the prosthesis. Forceps may also be used in a similar manner. Any number of sutures can be used to retain the end openings 225 in the open position, although triangulation sutures can be sufficient, with each suture being about 120 degrees apart from the adjacent suture.
  • a prosthesis is selected to have a radial expanded cross-section and a longitudinal length sufficient to bridge the laceration in the vessel or the gap between the body vessel portions 220 A, 220 B and radially fit within the body vessel portions.
  • the delivery assembly 200 is shown inserted into the body through the trauma pathway and positioned at the body vessel.
  • the system 10 with the prosthesis 15 is shown being situated and oriented adjacent the body vessel portions 220 A, 220 B.
  • the prosthesis 15 is in the delivery, compressed configuration, being at least partially retained in the radially compressed configuration by the sleeve 30 .
  • the first outer end 18 of the prosthesis 15 can be inserted into the vessel portion 220 A through the end opening 225 by a sufficient distance to allow the anchoring members of the prosthesis to engage within the tissue.
  • the vessel portion initially selected be the non-blood supplying vessel end.
  • the vessel portion 220 A may be manually pulled over the first outer end 18 of the prosthesis 15 .
  • the actuation member may be configured with at least two portions, where retraction of a first portion of the actuation member is configured to retract the sleeve portion associated with the first outer end, and retraction of a second portion of the actuation member is configured to retract the sleeve portion associated with the second outer end.
  • the outer ends of the prosthesis may be expanded simultaneously or in sequence.
  • the sleeve 30 can be removed from the first outer end 18 of the prosthesis, such as described herein, while inserted within the vessel portion 220 A.
  • the retraction member can be retracted in order to peel or split the removable sleeve 30 and remove it from the first outer end 18 of the prosthesis to allow for expansion thereof
  • FIG. 5B shows the actuation member 108 in a first position.
  • Each of the retraction members, such as the retractions members 46 C, 46 D of the sleeve 30 is shown gathered at the middle and positioned through the guiding element 135 , along the handle 101 , and extending through the retaining member 120 so that the enlarged ends 48 are engaged with the retaining member 120 .
  • This orientation puts the system 10 at the distal end of the tool 100 such that the tip 106 is contacted with the system 10 at approximately the center.
  • the tip 106 can apply a force at approximately the center of the system 10 suitable to retain the system 10 in a substantially fixed position relative to the tool 100 as the actuation member 108 is moved relative to the system 10 .
  • the tool 100 can be attached to the system 10 before entry of the system 10 within the body, and is inserted within the end opening 225 of at least one, if not both, body vessel portions 220 A, 220 B.
  • the system 10 without the tool 100 , may first be inserted into the end opening of at least one, if not both, body vessel portions in a manner such that the retraction members can extend outward through the trauma pathway.
  • the retraction members can then be coupled to the tool 100 as described herein.
  • the system 10 and the prosthesis 15 can then be manipulated in order to introduce the second outer end 19 of the prosthesis 15 into the vessel portion 220 B through the end opening by a sufficient distance to allow the anchoring members of the prosthesis to engage within the tissue.
  • the second outer end 19 of the prosthesis may be inserted into the vessel portion 220 B prior to, or subsequent to, the removal of the sleeve 30 from the first outer end 18 .
  • the vessel portion 220 B may be manually pulled over the second outer end 19 of the prosthesis 15 .
  • the sleeve 30 can be removed from the second outer end 19 of the prosthesis, such as described herein, while inserted within the vessel portion 220 B to allow for expansion thereof
  • the vessel portions 220 A, 220 B can now be sealably engaged to the first and second outer ends 18 , 19 of the prosthesis 15 .
  • the actuation member 108 can be moved relative to the prosthesis, such as, e.g., within the slot 109 from the first position toward the second position.
  • the retraction members can be moved relative to prosthesis to peel or split the sleeve 30 .
  • This action removes a portion of the sleeve 30 from the respective outer ends 18 , 19 in order to allow for radial expansion of the prosthesis 15 at its outer ends.
  • the actuation member 108 is in the second position.
  • the retraction members 46 C, 46 B and the sleeve 30 can be further moved relative to the prosthesis 15 such that the sleeve 30 is entirely removed from the prosthesis.
  • the radial expansion forces of the prosthesis may aid in the splitting of the sleeve.
  • the system and the sleeve together may be removed from the body. Accordingly, the prosthesis 15 is fully deployed to interconnect the first and second vessel portions 220 A, 220 B of the body vessel 220 to form a conduit for blood flow. The sutures can then be removed.
  • FIG. 5E shows the prosthesis 15 deployed and interconnecting body vessel portions 220 A, 220 B within the leg of the patient.
  • Prosthesis 15 can be adapted for permanently placement within the patient, thereby obviating a need for subsequent surgical intervention.
  • the prosthesis and the distal end of the handle can be manipulated in a laceration or opening formed in the wall of the body vessel.
  • the prosthesis may then be repositioned at a desired location with the body vessel.
  • the prosthesis can be expanded with the assembly 200 such as described herein.
  • the system 10 without the tool 100 can be used to deploy a prosthesis. The clinician would grasp the ends of the retraction member subsequent to positioning within the body vessel portions, and retract the retraction member ends relative to the prosthesis to allow for expansion of the outer ends of the prosthesis.
  • FIGS. 6A-6E illustrate an alternative system 300 and delivery method.
  • FIG. 6A depicts the system 300 including a prosthesis 15 retained in a radially compressed configuration within a removable sleeve 310 .
  • a partial cutaway of FIG. 6A shows the various layers of the prosthesis 15 , such as a support structure 320 and a graft body 322 in relation to the sleeve 310 .
  • the sleeve 310 can be configured to rapidly weaken, and preferably dissolve entirely, in response to application of an activation agent 330 to such configured sleeve.
  • the sleeve 310 can be weakened to a degree where the radial expansion forces of the prosthesis can overcome the retaining forces of the sleeve, thereby allowing the prosthesis to move to the radially expanded configuration. Thereafter, the 310 sleeve may continue to dissolve in its entirety.
  • the sleeve can have perforations. The number, shape, and size of the perforations can be selected for a desired dissolution rate. For example, a sleeve with more perforations can dissolve at a faster rate than the same sleeve with fewer perforations. The perforations may also allow for improved surface area contact, and anchoring, when the prosthesis is expanded in the middle of the dissolution process of the sleeve.
  • an activation agent 330 is saline, which is commonly found in the emergency room setting.
  • Materials of the sleeve 310 that dissolve once interfaced with saline include: pullulan which is an extracellular bacterial polysaccharide produced from starch by Aureobasidium pullulans; hydroxypropyl methyl cellulose; non animal-derived film-forming polymers, for example, polyvinyl alcohol, plant-derived film-forming polymers such as starch, starch derivatives, cellulose, celluloses derivatives other than the HPMC as defined herein and mixtures thereof, bacterial-derived film-forming polymers such as exo-polysaccharides like xanthan, acetan, gellan, welan, rhamsan, furcelleran, succinoglycan, scleroglycan, schizophyllan, tamarind gum, curdlan, dextran and mixtures thereof; and gelling systems including one or more cations and/or one or more gelling agents, with c
  • activation agents and corresponding sleeve materials can be selected to perform the same function.
  • Other examples include poly ethylene glycol, poly ethylene oxide, poly vinylpyrrolidone, a glycosaminoglycan, polysaccharides, polysaccharide derivatives, poly hyaluronic acid, poly alginic acid, chitin, chitosan, chitosan derivatives, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, poly peptides, poly lysine, poly glutamic acid, and proteins, such as albumin.
  • a polysaccharide may include tamarind gum (such as xyloglucan polymers), guar gum, chitosan, chitosan derivatives, locust bean gum (such as galactomannan polymers), and other industrial gums and polymers, which include, but are not limited to, Tara, Fenugreek, Aloe, Chia, Flaxseed, Psyllium seed, quince seed, xanthan, gellan, welan, rhamsan, dextran, curdlan, pullulan, scleroglucan, schizophyllan, chitin, hydroxyalkyl cellulose, arabinan (such as sugar beets), de-branched arabinan (such as from sugar beets), arabinoxylan (such as rye and wheat flour), galactan (such as from lupin and potatoes), pectic galactan (such as from potatoes), galactomannan (such as from carob, and including both
  • Such crosslinking of polymers is described in U.S. Pat. No. 7,960,453, which is incorporated herein by reference in its entirety. While any water-soluble material, such as cellulosic materials, gums, polymers, starches, proteins, and combinations thereof can be used, an example sleeve is made of glucans because of its high water solubility and rapid dissolution. Examples of glucans include pullulan and elsinan. It can be appreciated by those skilled in the art that other activation agents and corresponding sleeve materials can be selected to perform the same function.
  • the sleeve can be made by the following processes.
  • a solution of the desired sleeve material can be prepared in a water or saline solution.
  • a mandrel can be dipped into the solution to form a dip coating on the mandrel. It is recognized that the sleeve material may be applied by other means to coat the mandrel.
  • Some of the sleeve materials are thermoformable and can be extruded into a tubular segment.
  • Some of the sleeve material can be formed in a sheet that is rolled to form a tubular segment.
  • the coated mandrel can be dried in air to form the sleeve.
  • the prosthesis may be radially compressed with a stent compressor or by other known means in the art. The compressed prosthesis can be transferred to within the lumen of the sleeve.
  • the system 300 can be inserted manually through a laceration 339 of a body vessel 340 , as shown in FIG. 6B , and then repositioned to be substantially centered over the laceration, as shown in FIG. 6C .
  • the system 300 can be inserted into two vessel portions of a transected vessel.
  • the activation agent 330 can be applied to the sleeve 310 in order to begin the weakening or dissolving process.
  • FIG. 6D shows the use of a syringe suitably pressurized to release a sufficient amount of the activation agent 330 to rapidly weaken or dissolve sleeve 310 .
  • the time to weaken or dissolve the sleeve 310 can depend on the material and concentration of the sleeve and the activation agent, but it is desirable that the total time be as quick as possible, e.g., less than about 5 to 10 seconds.
  • FIG. 6E shows the prosthesis 15 in the radially expanded configuration engaged with the body vessel 340 after the sleeve 310 has dissolved, sealing the laceration 339 from within or interconnect the two vessel portions, in order to gain hemostasis or fluid stability and still allow blood perfusion or fluid flow.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Prostheses (AREA)
US13/197,074 2010-08-03 2011-08-03 Blood perfusion device delivery system Abandoned US20120035706A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/197,074 US20120035706A1 (en) 2010-08-03 2011-08-03 Blood perfusion device delivery system
US14/324,878 US9918824B2 (en) 2010-08-03 2014-07-07 Blood perfusion device delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37030410P 2010-08-03 2010-08-03
US13/197,074 US20120035706A1 (en) 2010-08-03 2011-08-03 Blood perfusion device delivery system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/324,878 Division US9918824B2 (en) 2010-08-03 2014-07-07 Blood perfusion device delivery system

Publications (1)

Publication Number Publication Date
US20120035706A1 true US20120035706A1 (en) 2012-02-09

Family

ID=44509672

Family Applications (3)

Application Number Title Priority Date Filing Date
US13/197,074 Abandoned US20120035706A1 (en) 2010-08-03 2011-08-03 Blood perfusion device delivery system
US13/197,511 Active 2031-10-07 US9192463B2 (en) 2010-08-03 2011-08-03 Blood perfusion device
US14/324,878 Active 2033-05-23 US9918824B2 (en) 2010-08-03 2014-07-07 Blood perfusion device delivery system

Family Applications After (2)

Application Number Title Priority Date Filing Date
US13/197,511 Active 2031-10-07 US9192463B2 (en) 2010-08-03 2011-08-03 Blood perfusion device
US14/324,878 Active 2033-05-23 US9918824B2 (en) 2010-08-03 2014-07-07 Blood perfusion device delivery system

Country Status (3)

Country Link
US (3) US20120035706A1 (de)
EP (1) EP2600794B1 (de)
WO (1) WO2012018929A1 (de)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9011514B2 (en) 2011-08-22 2015-04-21 Cook Medical Technologies Llc Emergency vessel repair prosthesis deployment system
US9345566B2 (en) 2012-09-26 2016-05-24 Cook Medical Technologies Llc Delivery device and system for open surgical repair
US9668742B2 (en) 2014-03-12 2017-06-06 Cook Medical Technologies Llc Occlusion device
US9808333B2 (en) 2012-09-26 2017-11-07 Cook Medical Technologies Llc Splittable sheath
US10111666B2 (en) 2014-11-05 2018-10-30 Cook Medical Technologies Llc Dissolvable sleeve configurations to aid graft deployment
WO2022011053A1 (en) * 2020-07-07 2022-01-13 The Johns Hopkins University Anastomotic coupling device

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0419954D0 (en) 2004-09-08 2004-10-13 Advotek Medical Devices Ltd System for directing therapy
US20130190676A1 (en) 2006-04-20 2013-07-25 Limflow Gmbh Devices and methods for fluid flow through body passages
US20120290072A1 (en) 2011-05-12 2012-11-15 Theobald Elizabeth A Emergency vascular repair prosthesis
JP6257515B2 (ja) 2011-06-15 2018-01-10 フラクシス インコーポレイテッド 吻合コネクターおよび送達のためのシステム
WO2013187927A1 (en) * 2012-06-15 2013-12-19 Phraxis Inc. Arterial and venous anchor devices forming an anastomotic connector and system for delivery
US11458007B2 (en) * 2012-08-10 2022-10-04 W. L. Gore & Associates, Inc. Devices and methods for limiting a depth of penetration for an anchor within an anatomy
US10835367B2 (en) 2013-03-08 2020-11-17 Limflow Gmbh Devices for fluid flow through body passages
CN114431933A (zh) 2013-03-08 2022-05-06 林弗洛公司 提供或维持通过身体通道的流体流的方法和系统
US9849006B2 (en) * 2013-03-15 2017-12-26 Children's Medical Center Corporation Methods and apparatuses for treating vessels
US9545263B2 (en) 2014-06-19 2017-01-17 Limflow Gmbh Devices and methods for treating lower extremity vasculature
CN110730634A (zh) 2017-04-10 2020-01-24 林弗洛公司 用于治疗下肢脉管系统的设备和方法
US11497632B2 (en) * 2018-07-30 2022-11-15 Cook Medical Technologies Llc Spring barb for medical device
CN112955207A (zh) 2018-10-09 2021-06-11 林弗洛公司 用于导管对准的设备和方法
JP2023500067A (ja) 2019-11-01 2023-01-04 リムフロウ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 肢遠位部への血液灌流を増加させるための装置及び方法
WO2024105217A1 (en) * 2022-11-18 2024-05-23 Dsm Ip Assets B.V. Graft

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442837A (en) * 1982-03-01 1984-04-17 Keatley Lawrence A Tweezers for the removal of parasites from animals
US4743265A (en) * 1986-04-23 1988-05-10 Dij Catheter Corp Articulated catheter placement device
US6254628B1 (en) * 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US6562048B1 (en) * 1998-08-31 2003-05-13 Thomas J. Fogarty Deformable conduits and methods for shunting bodily fluid during surgery
US20070198077A1 (en) * 2006-01-20 2007-08-23 Cully Edward H Device for rapid repair of body conduits
WO2008138529A1 (de) * 2007-05-11 2008-11-20 Nicola Rubenstein Vorrichtung zum verbinden zweier blutgefässe
US20090204196A1 (en) * 2008-02-11 2009-08-13 Boston Scientific Scimed, Inc. Self-expandable stent with a constrictive coating and method of use

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2164562A (en) 1984-09-21 1986-03-26 Colin Campbell Mackenzie Device to facilitate reconnection of tubular vessels in a body
EP1217101B8 (de) 1994-04-29 2006-02-01 Boston Scientific Scimed, Inc. Stent mit Kollagen
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US5591226A (en) 1995-01-23 1997-01-07 Schneider (Usa) Inc. Percutaneous stent-graft and method for delivery thereof
US5591197A (en) 1995-03-14 1997-01-07 Advanced Cardiovascular Systems, Inc. Expandable stent forming projecting barbs and method for deploying
CA2171896C (en) * 1995-03-17 2007-05-15 Scott C. Anderson Multi-anchor stent
US6193745B1 (en) 1995-10-03 2001-02-27 Medtronic, Inc. Modular intraluminal prosteheses construction and methods
US6042605A (en) 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
US5830217A (en) * 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
DE69725592T2 (de) 1996-08-23 2004-08-05 Cook Biotech, Inc., West Lafayette Verfahren zur gewinnung einer gereignigten matrix auf kollagenbasis aus submukosa gewebe
US6197013B1 (en) 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
US6261320B1 (en) 1996-11-21 2001-07-17 Radiance Medical Systems, Inc. Radioactive vascular liner
US5824053A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
US6287335B1 (en) 1999-04-26 2001-09-11 William J. Drasler Intravascular folded tubular endoprosthesis
US6729356B1 (en) 2000-04-27 2004-05-04 Endovascular Technologies, Inc. Endovascular graft for providing a seal with vasculature
US20010044650A1 (en) * 2001-01-12 2001-11-22 Simso Eric J. Stent for in-stent restenosis
US20030074055A1 (en) 2001-10-17 2003-04-17 Haverkost Patrick A. Method and system for fixation of endoluminal devices
US7147661B2 (en) * 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
CA2468951A1 (en) 2001-12-20 2003-07-03 Trivascular, Inc. Advanced endovascular graft
US7331992B2 (en) 2002-02-20 2008-02-19 Bard Peripheral Vascular, Inc. Anchoring device for an endoluminal prosthesis
AU2003243204B2 (en) * 2002-05-16 2008-09-18 Cook Medical Technologies Llc Flexible barb for anchoring a prosthesis
US20040117004A1 (en) 2002-05-16 2004-06-17 Osborne Thomas A. Stent and method of forming a stent with integral barbs
US7044962B2 (en) 2002-06-25 2006-05-16 Scimed Life Systems, Inc. Implantable prosthesis with displaceable skirt
AU2003256499A1 (en) 2002-07-11 2004-02-02 Setagon, Inc. Expandable body having deployable microstructures and related methods
AU2003265477B2 (en) 2002-08-15 2009-08-13 Cook Medical Technologies Llc Stent and method of forming a stent with integral barbs
DE602004024972D1 (de) 2003-04-08 2010-02-25 Cook Inc Intraluminale stützvorrichtung mit graft
US6846323B2 (en) 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
US7947766B2 (en) 2003-06-06 2011-05-24 The Procter & Gamble Company Crosslinking systems for hydroxyl polymers
US8721710B2 (en) 2003-08-11 2014-05-13 Hdh Medical Ltd. Anastomosis system and method
WO2005048880A2 (de) 2003-11-18 2005-06-02 Medizinische Universität Wien Gefässprothese
DE602005020754D1 (de) 2004-03-31 2010-06-02 Cook Inc Transplantatmaterial und gefässprothese mit extrazellulärer kollagenmatrix und dessen herstellungsverfahren
EP1827304B1 (de) * 2004-10-25 2011-04-20 Merit Medical Systems, Inc. Vorrichtung zum entfernen und versetzen eines stents
US8202311B2 (en) 2005-07-27 2012-06-19 Cook Medical Technologies Llc Stent/graft device and method for open surgical placement
AU2006343882A1 (en) * 2006-05-23 2007-11-29 Allvascular Pty Ltd Endovenous valve transfer stent
US9474833B2 (en) * 2006-12-18 2016-10-25 Cook Medical Technologies Llc Stent graft with releasable therapeutic agent and soluble coating
EP2211777B1 (de) 2007-10-26 2015-09-30 Cook Medical Technologies LLC Gefässleitung und abgabesystem zur offenen chirurgischen platzierung
US8192479B2 (en) 2007-11-30 2012-06-05 Cook Medical Technologies Llc Method and device for vascular therapy
US8128677B2 (en) * 2007-12-12 2012-03-06 Intact Vascular LLC Device and method for tacking plaque to a blood vessel wall
US20090171454A1 (en) * 2007-12-27 2009-07-02 Cook Incorporated Coated stent and methods of manufacture
WO2009114344A2 (en) 2008-03-10 2009-09-17 Nfocus Neuromedical, Inc. Stents and stent grafts
US8657866B2 (en) * 2010-12-22 2014-02-25 Cook Medical Technologies Llc Emergency vascular repair prosthesis deployment system

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442837A (en) * 1982-03-01 1984-04-17 Keatley Lawrence A Tweezers for the removal of parasites from animals
US4743265A (en) * 1986-04-23 1988-05-10 Dij Catheter Corp Articulated catheter placement device
US6254628B1 (en) * 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US6562048B1 (en) * 1998-08-31 2003-05-13 Thomas J. Fogarty Deformable conduits and methods for shunting bodily fluid during surgery
US20070198077A1 (en) * 2006-01-20 2007-08-23 Cully Edward H Device for rapid repair of body conduits
WO2008138529A1 (de) * 2007-05-11 2008-11-20 Nicola Rubenstein Vorrichtung zum verbinden zweier blutgefässe
US20100324653A1 (en) * 2007-05-11 2010-12-23 Nicola Rubenstein Device for connecting two blood vessels
US8388634B2 (en) * 2007-05-11 2013-03-05 Nicola Osypka Rubenstein Device for connecting two blood vessels
US20090204196A1 (en) * 2008-02-11 2009-08-13 Boston Scientific Scimed, Inc. Self-expandable stent with a constrictive coating and method of use

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9011514B2 (en) 2011-08-22 2015-04-21 Cook Medical Technologies Llc Emergency vessel repair prosthesis deployment system
US9549834B2 (en) 2011-08-22 2017-01-24 Cook Medical Technologies Llc Emergency vessel repair prosthesis deployment system
US9345566B2 (en) 2012-09-26 2016-05-24 Cook Medical Technologies Llc Delivery device and system for open surgical repair
US9808333B2 (en) 2012-09-26 2017-11-07 Cook Medical Technologies Llc Splittable sheath
US9668742B2 (en) 2014-03-12 2017-06-06 Cook Medical Technologies Llc Occlusion device
US10111666B2 (en) 2014-11-05 2018-10-30 Cook Medical Technologies Llc Dissolvable sleeve configurations to aid graft deployment
WO2022011053A1 (en) * 2020-07-07 2022-01-13 The Johns Hopkins University Anastomotic coupling device

Also Published As

Publication number Publication date
US20120035708A1 (en) 2012-02-09
EP2600794B1 (de) 2015-12-09
US9918824B2 (en) 2018-03-20
EP2600794A1 (de) 2013-06-12
US9192463B2 (en) 2015-11-24
WO2012018929A1 (en) 2012-02-09
US20140324155A1 (en) 2014-10-30

Similar Documents

Publication Publication Date Title
US9918824B2 (en) Blood perfusion device delivery system
US20180325652A1 (en) Prosthesis delivery system with retention sleeve
JP5972896B2 (ja) 脈管修復用の人工器官配置システム
US9314358B2 (en) Emergency vascular repair prosthesis deployment system
US11278390B2 (en) Stent graft with fenestration lock and methods of use
US11801129B2 (en) Vascular prosthesis with fenestration ring and methods of use
US8784474B2 (en) Emergency vascular repair system and method
JP4575451B2 (ja) 血管枝用モジュール式人工器官および方法
EP1906879B1 (de) Stent-graft-vorrichtung für offenen chirurgischen einsatz
JP7504156B2 (ja) 血管グラフト
US11458008B2 (en) Hybrid prosthesis and delivery system
US9089413B2 (en) Emergency vascular repair prosthesis
US20120271400A1 (en) Introducer for a vascular repair prosthesis
JP2007508069A (ja) ステントグラフト保持システム
US20160235567A1 (en) Delivery device and system for open surgical repair
US10111764B2 (en) Prosthesis including retractable anchoring members
US20130053861A1 (en) Open surgical prosthesis deployment system
US12023236B2 (en) Hybrid prosthesis and delivery system
EP3215053B1 (de) Auflösbare hülsenkonfigurationen zur unterstützung der freisetzung eines transplantats

Legal Events

Date Code Title Description
AS Assignment

Owner name: COOK INCORPORATED, INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:PAUL, RAM H., JR.;BURKE, JESSICA L.;SIGNING DATES FROM 20110728 TO 20110729;REEL/FRAME:026719/0246

AS Assignment

Owner name: COOK MEDICAL TECHNOLOGIES LLC, INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COOK INCORPORATED;REEL/FRAME:026727/0166

Effective date: 20110801

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION