US20110077675A1 - Pain management bio-medical unit - Google Patents
Pain management bio-medical unit Download PDFInfo
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- US20110077675A1 US20110077675A1 US12/848,830 US84883010A US2011077675A1 US 20110077675 A1 US20110077675 A1 US 20110077675A1 US 84883010 A US84883010 A US 84883010A US 2011077675 A1 US2011077675 A1 US 2011077675A1
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Definitions
- This invention relates generally to medical equipment and more particularly to wireless medical equipment.
- MRI magnetic resonance imaging
- RFID radio frequency identification
- robotics etc.
- RFID technology has been used for in vitro use to store patient information for easy access. While such in vitro applications have begun, the technical advancement in this area is in its infancy.
- FIG. 1 is a diagram of an embodiment of a system in accordance with the present invention.
- FIG. 2 is a diagram of another embodiment of a system in accordance with the present invention.
- FIG. 3 is a diagram of an embodiment of an artificial body part including one or more bio-medical units in accordance with the present invention
- FIG. 4 is a schematic block diagram of an embodiment of an artificial body part in accordance with the present invention.
- FIG. 5 is a diagram of another embodiment of a system in accordance with the present invention.
- FIG. 6 is a diagram of another embodiment of a system in accordance with the present invention.
- FIG. 7 is a diagram of another embodiment of a system in accordance with the present invention.
- FIG. 8 is a schematic block diagram of an embodiment of a bio-medical unit in accordance with the present invention.
- FIG. 9 is a schematic block diagram of an embodiment of a power harvesting module in accordance with the present invention.
- FIG. 10 is a schematic block diagram of another embodiment of a power harvesting module in accordance with the present invention.
- FIG. 11 is a schematic block diagram of another embodiment of a power harvesting module in accordance with the present invention.
- FIG. 12 is a schematic block diagram of another embodiment of a power harvesting module in accordance with the present invention.
- FIG. 13 is a schematic block diagram of an embodiment of a power boost module in accordance with the present invention.
- FIG. 14 is a schematic block diagram of an embodiment of an electromagnetic (EM)) power harvesting module in accordance with the present invention.
- EM electromagnetic
- FIG. 15 is a schematic block diagram of another embodiment of an electromagnetic (EM)) power harvesting module in accordance with the present invention.
- EM electromagnetic
- FIG. 16 is a schematic block diagram of another embodiment of a bio-medical unit in accordance with the present invention.
- FIG. 17 is a diagram of another embodiment of a system in accordance with the present invention.
- FIG. 18 is a diagram of an example of a communication protocol within a system in accordance with the present invention.
- FIG. 19 is a diagram of another embodiment of a system in accordance with the present invention.
- FIG. 20 is a diagram of another example of a communication protocol within a system in accordance with the present invention.
- FIG. 21 is a diagram of an embodiment of a network of bio-medical units that include MEMS robotics in accordance with the present invention.
- FIG. 22 is a diagram of another embodiment of a network of bio-medical units that include MEMS robotics in accordance with the present invention.
- FIG. 23 is a diagram of an embodiment of a network of bio-medical units for facilitating electrical stimulus treatment in accordance with the present invention.
- FIG. 24 is a diagram of an embodiment of power conversion modules in a bio-medical unit of FIG. 23 in accordance with the present invention.
- FIG. 25 is a diagram of an embodiment of a bio-medical unit facilitating pain blocking in accordance with the present invention.
- FIG. 26 is a diagram of an embodiment of a bio-medical unit including sampling modules in accordance with the present invention.
- FIG. 27 is a diagram of another embodiment of a bio-medical unit facilitating pain blocking in accordance with the present invention.
- FIG. 28 is a diagram of another embodiment of a bio-medical unit facilitating pain blocking in accordance with the present invention.
- FIG. 1 is a diagram of an embodiment of a system that includes a plurality of bio-medical units 10 embedded within a body and/or placed on the surface of the body to facilitate diagnosis, treatment, and/or data collections.
- Each of the bio-medical units 10 is a passive device (e.g., it does not include a power source (e.g., a battery)) and, as such, includes a power harvesting module.
- the bio-medical units 10 may also include one or more of memory, a processing module, and functional modules. Alternatively, or in addition to, each of the bio-medical units 10 may include a rechargeable power source.
- a transmitter 12 emits electromagnetic signals 16 that pass through the body and are received by a receiver 14 .
- the transmitter 12 and receiver 14 may be part of a piece of medical diagnostic equipment (e.g., magnetic resonance imaging (MRI), X-ray, etc.) or independent components for stimulating and communicating with the network of bio-medical units in and/or on a body.
- One or more of the bio-medical units 10 receives the transmitted electromagnetic signals 16 and generates a supply voltage therefrom. Examples of this will be described in greater detail with reference to FIGS. 8-12 .
- the transmitter 12 communicates with one or more of the bio-medical units 10 .
- the electromagnetic signals 16 may have a frequency in the range of a few MHz to 900 MHz and the communication with the bio-medical units 10 is modulated on the electromagnetic signals 16 at a much higher frequency (e.g., 5 GHz to 300 GHz).
- the communication with the bio-medical units 10 may occur during gaps (e.g., per protocol of medical equipment or injected for communication) of transmitting the electromagnetic signals 16 .
- the communication with the bio-medical units 10 occurs in a different frequency band and/or using a different transmission medium (e.g., use RF or MMW signals when the magnetic field of the electromagnetic signals are dominate, use ultrasound signals when the electromagnetic signals 16 are RF and/or MMW signals, etc.).
- a different transmission medium e.g., use RF or MMW signals when the magnetic field of the electromagnetic signals are dominate, use ultrasound signals when the electromagnetic signals 16 are RF and/or MMW signals, etc.
- the communication signals 18 may be instructions to collect data, to transmit collected data, to move the unit's position in the body, to perform a function, to administer a treatment, etc. If the received communication signals 18 require a response, the bio-medical unit 10 prepares an appropriate response and transmits it to the receiver 14 using a similar communication convention used by the transmitter 12 .
- FIG. 2 is a diagram of another embodiment of a system that includes a plurality of bio-medical units 10 embedded within a body and/or placed on the surface of the body to facilitate diagnosis, treatment, and/or data collections.
- Each of the bio-medical units 10 is a passive device and, as such, includes a power harvesting module.
- the bio-medical units 10 may also include one or more of memory, a processing module, and functional modules.
- the person is placed in an MRI machine (fixed or portable) that generates a magnetic field 26 through which the MRI transmitter 20 transmits MRI signals 28 to the MRI receiver 22 .
- One or more of the bio-medical units 10 powers itself by harvesting energy from the magnetic field 26 or changes thereof as produced by gradient coils, from the magnetic fields of the MRI signals 28 , from the electrical fields of the MRI signals 28 , and/or from the electromagnetic aspects of the MRI signals 28 .
- a unit 10 converts the harvested energy into a supply voltage that supplies other components of the unit (e.g., a communication module, a processing module, memory, a functional module, etc.).
- a communication device 24 communicates data and/or control communications 30 with one or more of the bio-medical units 10 over one or more wireless links.
- the communication device 24 may be a separate device from the MRI machine or integrated into the MRI machine.
- the communication device 24 may be a cellular telephone, a computer with a wireless interface (e.g., a WLAN station and/or access point, Bluetooth, a proprietary protocol, etc.), etc.
- a wireless link may be one or more frequencies in the ISM band, in the 60 GHz frequency band, the ultrasound frequency band, and/or other frequency bands that supports one or more communication protocols (e.g., data modulation schemes, beamforming, RF or MMW modulation, encoding, error correction, etc.).
- the composition of the bio-medical units 10 includes non-ferromagnetic materials (e.g., paramagnetic or diamagnetic) and/or metal alloys that are minimally affected by an external magnetic field 26 .
- the units harvest power from the MRI signals 28 and communicate using RF and/or MMW electromagnetic signals with negligible chance of encountering the projectile or missile effect of implants that include ferromagnetic materials.
- FIG. 3 is a diagram of an embodiment of an artificial body part 32 including one or more bio-medical units 10 that may be surgically implanted into a body.
- the artificial body part 32 may be a pace maker, a breast implant, a joint replacement, an artificial bone, splints, fastener devices (e.g., screws, plates, pins, sutures, etc.), artificial organ, etc.
- the artificial body part 32 may be permanently embedded in the body or temporarily embedded into the body.
- FIG. 4 is a schematic block diagram of an embodiment of an artificial body part 32 that includes one or more bio-medical units 10 .
- one bio-medical unit 10 may be used to detect infections, the body's acceptance of the artificial body part 32 , measure localized body temperature, monitor performance of the artificial body part 32 , and/or data gathering for other diagnostics.
- Another bio-medical unit 10 may be used for deployment of treatment (e.g., disperse medication, apply electrical stimulus, apply RF radiation, apply laser stimulus, etc.).
- Yet another bio-medical unit 10 may be used to adjust the position of the artificial body part 32 and/or a setting of the artificial body part 32 .
- a bio-medical unit 10 may be used to mechanically adjust the tension of a splint, screws, etc.
- a bio-medical unit 10 may be used to adjust an electrical setting of the artificial body part 32 .
- FIG. 5 is a diagram of another embodiment of a system that includes a plurality of bio-medical units 10 and one or more communication devices 24 coupled to a wide area network (WAN) communication device 34 (e.g., a cable modem, DSL modem, base station, access point, hot spot, etc.).
- the WAN communication device 34 is coupled to a network 42 (e.g., cellular telephone network, internet, etc.), which has coupled to it a plurality of remote monitors 36 , a plurality of databases 40 , and a plurality of computers 38 .
- the communication device 24 includes a processing module and a wireless transceiver module (e.g., one or more transceivers) and may function similarly to communication module 48 as described in FIG. 8 ,
- a bio-medical unit includes a power harvesting module, a communication module, and one or more functional modules.
- the power harvesting module operable to produce a supply voltage from a received electromagnetic power signal (e.g., the electromagnetic signal 16 of FIGS. 1 and 2 , the MRI signals of one or more the subsequent figures).
- the communication module and the at least one functional module are powered by the supply voltage.
- the communication device 24 receives a downstream WAN signal from the network 42 via the WAN communication device 34 .
- the downstream WAN signal may be generated by a remote monitoring device 36 , a remote diagnostic device (e.g., computer 38 performing a remote diagnostic function), a remote control device (e.g., computer 38 performing a remote control function), and/or a medical record storage device (e.g., database 40 ).
- the communication device 24 converts the downstream WAN signal into a downstream data signal.
- the communication device 24 may convert the downstream WAN signal into a symbol stream in accordance with one or more wireless communication protocols (e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.).
- the communication device 24 may convert the symbol stream into the downstream data signal using the same or a different wireless communication protocol.
- the communication device 24 may convert the symbol stream into data that it interprets to determine how to structure the communication with the bio-medical unit 10 and/or what data (e.g., instructions, commands, digital information, etc.) to include in the downstream data signal. Having determined how to structure and what to include in the downstream data signal, the communication device 24 generates the downstream data signal in accordance with one or more wireless communication protocols. As yet another alternative, the communication device 24 may function as a relay, which provides the downstream WAN signal as the downstream data signal to the one or more bio-medical units 10 .
- the communication device 24 When the communication device 24 has (and/or is processing) the downstream data signal to send to the bio-medical unit, it sets up a communication with the bio-medical unit.
- the set up may include identifying the particular bio-medical unit(s), determining the communication protocol used by the identified bio-medical unit(s), sending a signal to an electromagnetic device (e.g., MRI device, etc.) to request that it generates the electromagnetic power signal to power the bio-medical unit, and/or initiate a communication in accordance with the identified communication protocol.
- an electromagnetic device e.g., MRI device, etc.
- the communication device may include an electromagnetic device to create the electromagnetic power signal.
- the communication device 24 wirelessly communicates the downstream data signal to the communication module of the bio-medical unit 10 .
- the functional module of the bio-medical unit 10 processes the downstream data contained in the downstream data signal to perform a bio-medical functional, to store digital information contained in the downstream data, to administer a treatment (e.g., administer a medication, apply laser stimulus, apply electrical stimulus, etc.), to collect a sample (e.g., blood, tissue, cell, etc.), to perform a micro electro-mechanical function, and/or to collect data.
- a treatment e.g., administer a medication, apply laser stimulus, apply electrical stimulus, etc.
- a sample e.g., blood, tissue, cell, etc.
- micro electro-mechanical function e.g., blood, tissue, cell, etc.
- the bio-medical function may include capturing a digital image, capturing a radio frequency (e.g., 300 MHz to 300 GHz) radar image, an ultrasound image, a tissue sample, and/or a measurement (e.g., blood pressure, temperature, pulse, blood-oxygen level, blood sugar level, etc.).
- a radio frequency e.g., 300 MHz to 300 GHz
- an ultrasound image e.g., an ultrasound image
- tissue sample e.g., a tissue sample
- a measurement e.g., blood pressure, temperature, pulse, blood-oxygen level, blood sugar level, etc.
- the functional module When the downstream data requires a response, the functional module performs a bio-medical function to produce upstream data.
- the communication module converts the upstream data into an upstream data signal in accordance with the one or more wireless protocols.
- the communication device 24 converts the upstream data signal into an upstream wide area network (WAN) signal and transmits it to a remote diagnostic device, a remote control device, and/or a medical record storage device. In this manner, a person(s) operating the remote monitors 36 may view images and/or the data 30 gathered by the bio-medical units 10 . This enables a specialist to be consulted without requiring the patient to travel to the specialist's office.
- WAN wide area network
- one or more of the computers 38 may communicate with the bio-medical units 10 via the communication device 24 , the WAN communication device 34 , and the network 42 .
- the computer 36 may provide commands 30 to one or more of the bio-medical units 10 to gather data, to dispense a medication, to move to a new position in the body, to perform a mechanical function (e.g., cut, grasp, drill, puncture, stitch, patch, etc.), etc.
- the bio-medical units 10 may be remotely controlled via one or more of the computers 36 .
- one or more of the bio-medical units 10 may read and/or write data from or to one or more of the databases 40 .
- data e.g., a blood sample analysis
- the communication device 24 and/or one of the computers 36 may control the writing of data to or the reading of data from the database(s) 40 .
- the data may further include medical records, medical images, prescriptions, etc.
- FIG. 6 is a diagram of another embodiment of a system that includes a plurality of bio-medical units 10 .
- the bio-medical units 10 can communicate with each other directly and/or communicate with the communication device 24 directly.
- the communication medium may be an infrared channel(s), an RF channel(s), a MMW channel(s), and/or ultrasound.
- the units may use a communication protocol such as token passing, carrier sense, time division multiplexing, code division multiplexing, frequency division multiplexing, etc.
- FIG. 7 is a diagram of another embodiment of a system that includes a plurality of bio-medical units 10 .
- one of the bio-medical units 44 functions as an access point for the other units.
- the designated unit 44 routes communications between the units 10 and between one or more units 10 and the communication device 24 .
- the communication medium may be an infrared channel(s), an RF channel(s), a MMW channel(s), and/or ultrasound.
- the units 10 may use a communication protocol such as token passing, carrier sense, time division multiplexing, code division multiplexing, frequency division multiplexing, etc.
- FIG. 8 is a schematic block diagram of an embodiment of a bio-medical unit 10 that includes a power harvesting module 46 , a communication module 48 , a processing module 50 , memory 52 , and one or more functional modules 54 .
- the processing module 50 may be a single processing device or a plurality of processing devices.
- Such a processing device may be a microprocessor, micro-controller, digital signal processor, microcomputer, central processing unit, field programmable gate array, programmable logic device, state machine, logic circuitry, analog circuitry, digital circuitry, and/or any device that manipulates signals (analog and/or digital) based on hard coding of the circuitry and/or operational instructions.
- the processing module 50 may have an associated memory 52 and/or memory element, which may be a single memory device, a plurality of memory devices, and/or embedded circuitry of the processing module.
- a memory device 52 may be a read-only memory, random access memory, volatile memory, non-volatile memory, static memory, dynamic memory, flash memory, cache memory, and/or any device that stores digital information.
- the processing module 50 includes more than one processing device, the processing devices may be centrally located (e.g., directly coupled together via a wired and/or wireless bus structure) or may be distributedly located (e.g., cloud computing via indirect coupling via a local area network and/or a wide area network).
- the processing module 50 implements one or more of its functions via a state machine, analog circuitry, digital circuitry, and/or logic circuitry
- the memory and/or memory element storing the corresponding operational instructions may be embedded within, or external to, the circuitry comprising the state machine, analog circuitry, digital circuitry, and/or logic circuitry.
- the memory element stores, and the processing module executes, hard coded and/or operational instructions corresponding to at least some of the steps and/or functions illustrated in FIGS. 1-26 .
- the power harvesting module 46 may generate one or more supply voltages 56 (Vdd) from a power source signal (e.g., one or more of MRI electromagnetic signals 16 , magnetic fields 26 , RF signals, MMW signals, ultrasound signals, light signals, and body motion).
- a power source signal e.g., one or more of MRI electromagnetic signals 16 , magnetic fields 26 , RF signals, MMW signals, ultrasound signals, light signals, and body motion.
- the power harvesting module 46 may be implemented as disclosed in U.S. Pat. No. 7,595,732 to generate one or more supply voltages from an RF signal.
- the power harvesting module 46 may be implemented as shown in one or more FIGS. 9-11 to generate one or more supply voltages 56 from an MRI signal 28 and/or magnetic field 26 .
- the power harvesting module 46 may be implemented as shown in FIG. 12 to generate one or more supply voltage 56 from body motion. Regardless of how the power harvesting module generates the supply voltage(s), the supply voltage(s) are used to
- a receiver section of the communication module 48 receives an inbound wireless communication signal 60 and converts it into an inbound symbol stream.
- the receiver section amplifies an inbound wireless (e.g., RF or MMW) signal 60 to produce an amplified inbound RF or MMW signal.
- the receiver section may then mix in-phase (I) and quadrature (Q) components of the amplified inbound RF or MMW signal with in-phase and quadrature components of a local oscillation to produce a mixed I signal and a mixed Q signal.
- the mixed I and Q signals are combined to produce an inbound symbol stream.
- the inbound symbol may include phase information (e.g., +/ ⁇ [phase shift] and/or ⁇ (t) [phase modulation]) and/or frequency information (e.g., +/ ⁇ f [frequency shift] and/or f(t) [frequency modulation]).
- the inbound RF or MMW signal includes amplitude information (e.g., +/ ⁇ A [amplitude shift] and/or A(t) [amplitude modulation]).
- the receiver section includes an amplitude detector such as an envelope detector, a low pass filter, etc.
- the processing module 50 converts the inbound symbol stream into inbound data and generates a command message based on the inbound data.
- the command message may instruction one or more of the functional modules to perform one or more electro-mechanical functions of gathering data (e.g., imaging data, flow monitoring data), dispensing a medication, moving to a new position in the body, performing a mechanical function (e.g., cut, grasp, drill, puncture, stitch, patch, etc.), dispensing a treatment, collecting a biological sample, etc.
- the processing module 50 may perform one or more of: digital intermediate frequency to baseband conversion, time to frequency domain conversion, space-time-block decoding, space-frequency-block decoding, demodulation, frequency spread decoding, frequency hopping decoding, beamforming decoding, constellation demapping, deinterleaving, decoding, depuncturing, and/or descrambling.
- Such a conversion is typically prescribed by one or more wireless communication standards (e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.).
- wireless communication standards e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.
- the processing module 50 provides the command message to one or more of the micro-electromechanical functional modules 54 .
- the functional module 54 performs an electro-mechanical function within a hosting body in accordance with the command message.
- Such an electro-mechanical function includes at least one of data gathering (e.g., image, flow monitoring), motion, repairs, dispensing medication, biological sampling, diagnostics, applying laser treatment, applying ultrasound treatment, grasping, sawing, drilling, providing an electronic stimulus etc.
- data gathering e.g., image, flow monitoring
- motion e.g., motion, repairs, dispensing medication, biological sampling, diagnostics, applying laser treatment, applying ultrasound treatment, grasping, sawing, drilling, providing an electronic stimulus etc.
- the functional modules 54 may be implemented using nanotechnology and/or microelectronic mechanical systems (MEMS) technology.
- MEMS microelectronic mechanical systems
- the micro electro-mechanical functional module 54 When requested per the command message (e.g. gather data and report the data), the micro electro-mechanical functional module 54 generates an electro-mechanical response based on the performing the electro-mechanical function.
- the response may be data (e.g., heart rate, blood sugar levels, temperature, blood flow rate, image of a body object, etc.), a biological sample (e.g., blood sample, tissue sample, etc.), acknowledgement of performing the function (e.g., acknowledge a software update, storing of data, etc.), and/or any appropriate response.
- the micro electro-mechanical functional module 54 provides the response to the processing module 50 .
- the processing module 50 converts the electro-mechanical response into an outbound symbol stream, which may be done in accordance with one or more wireless communication standards (e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.).
- wireless communication standards e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.
- Such a conversion includes one or more of: scrambling, puncturing, encoding, interleaving, constellation mapping, modulation, frequency spreading, frequency hopping, beamforming, space-time-block encoding, space-frequency-block
- a transmitter section of the communication module 48 converts an outbound symbol stream into an outbound RF or MMW signal 60 that has a carrier frequency within a given frequency band (e.g., 900 MHz, 2.5 GHz, 5 GHz, 57-66 GHz, etc.). In an embodiment, this may be done by mixing the outbound symbol stream with a local oscillation to produce an up-converted signal.
- One or more power amplifiers and/or power amplifier drivers amplifies the up-converted signal, which may be RF or MMW bandpass filtered, to produce the outbound RF or MMW signal 60 .
- the transmitter section includes an oscillator that produces an oscillation.
- the outbound symbol stream provides phase information (e.g., +/ ⁇ [phase shift] and/or ⁇ (t) [phase modulation]) that adjusts the phase of the oscillation to produce a phase adjusted RF or MMW signal, which is transmitted as the outbound RF signal 60 .
- the outbound symbol stream includes amplitude information (e.g., A(t) [amplitude modulation]), which is used to adjust the amplitude of the phase adjusted RF or MMW signal to produce the outbound RF or MMW signal 60 .
- the transmitter section includes an oscillator that produces an oscillation.
- the outbound symbol provides frequency information (e.g., +/ ⁇ f [frequency shift] and/or f(t) [frequency modulation]) that adjusts the frequency of the oscillation to produce a frequency adjusted RF or MMW signal, which is transmitted as the outbound RF or MMW signal 60 .
- the outbound symbol stream includes amplitude information, which is used to adjust the amplitude of the frequency adjusted RF or MMW signal to produce the outbound RF or MMW signal 60 .
- the transmitter section includes an oscillator that produces an oscillation.
- the outbound symbol provides amplitude information (e.g., +/ ⁇ A [amplitude shift] and/or A(t) [amplitude modulation) that adjusts the amplitude of the oscillation to produce the outbound RF or MMW signal 60 .
- the bio-medical unit 10 may be encapsulated by an encapsulate 58 that is non-toxic to the body.
- the encapsulate 58 may be a silicon based product, a non-ferromagnetic metal alloy (e.g., stainless steel), etc.
- the encapsulate 58 may include a spherical shape and have a ferromagnetic liner that shields the unit from a magnetic field and to offset the forces of the magnetic field.
- the bio-medical unit 10 may be implemented on a single die that has an area of a few millimeters or less. The die may be fabricated in accordance with CMOS technology, Gallium-Arsenide technology, and/or any other integrated circuit die fabrication process.
- one of the functional modules 54 functions as a first micro-electro mechanical module and another one of the functions modules 54 functions as a second micro-electro mechanical module.
- the bio-medical unit is implanted into a host body (e.g., a person, an animal, a reptile, etc.) at a position proximal to a body object to be monitored and/or have an image taken thereof.
- the body object may be a vein, an artery, an organ, a cyst (or other growth), etc.
- the bio-medical unit may be positioned approximately parallel to the flow of blood in a vein, artery, and/or the heart.
- the first micro-electro mechanical module When powered by the supply voltage, the first micro-electro mechanical module generates and transmits a wireless signal at, or around, the body object.
- the second micro-electro mechanical module receives a representation of the wireless signal (e.g., a reflection of the wireless signal, a refraction of the wireless signal, or a determined absorption of the wireless signal).
- the wireless signal may be an ultrasound signal, a radio frequency signal, and/or a millimeter wave signal.
- the processing module 50 may coordinate the transmitting of the wireless signal and the receiving of the representation of the wireless signal. For example, the processing module may receive, via the communication module, a command to enable the transmitting of the wireless signal (e.g., an ultrasound signal) and the receiving of the representation of the wireless signal. In response, the processing module generates a control signal that it provides to the first micro-electro mechanical module to enable it to transmit the wireless signal.
- a command to enable the transmitting of the wireless signal (e.g., an ultrasound signal) and the receiving of the representation of the wireless signal.
- the processing module generates a control signal that it provides to the first micro-electro mechanical module to enable it to transmit the wireless signal.
- the processing module may generate flow monitoring data based on the second micro-electro mechanical module receiving of the representation of the wireless signal.
- the processing module calculates a fluid flow rate based on phase shifting and/or frequency shifting between the transmitting of the wireless signal and the receiving of the representation of the wireless signal.
- the processing module gathers phase shifting data and/or frequency shifting data based on the transmitting of the wireless signal and the receiving of the representation of the wireless signal.
- the processing module may further generate imaging data based on the second micro-electro mechanical module receiving the representation of the wireless signal.
- the processing module calculates an image of the body object based absorption of the wireless signal by the body object and/or vibration of the body object.
- the processing module gathers data regarding the absorption of the wireless signal by the body object and/or of the vibration of the body object.
- a bio-medical unit may include one or the other module.
- a bio-medical unit may include a micro-electro mechanical module for transmitting a wireless signal, where the receiver is external to the body or in another bio-medical unit.
- a bio-medical unit may include a micro-electro mechanical module for receiving a representation of a wireless signal, where the transmitter is external to the body or another bio-medical unit.
- FIG. 9 is a schematic block diagram of an embodiment of a power harvesting module 46 that includes an array of on-chip air core inductors 64 , a rectifying circuit 66 , capacitors, and a regulation circuit 68 .
- the inductors 64 may each having an inductance of a few nano-Henries to a few micro-Henries and may be coupled in series, in parallel, or a series parallel combination.
- the MRI transmitter 20 transmits MRI signals 28 at a frequency of 3-45 MHz at a power level of up to 35 KWatts.
- the air core inductors 64 are electromagnetically coupled to generate a voltage from the magnetic and/or electric field generated by the MRI signals 28 .
- the air core inductors 64 may generate a voltage from the magnetic field 26 and changes thereof produced by the gradient coils.
- the rectifying circuit 66 rectifies the AC voltage produced by the inductors to produce a first DC voltage.
- the regulation circuit generates one or more desired supply voltages 56 from the first DC voltage.
- the inductors 64 may be implemented on one more metal layers of the die and include one or more turns per layer. Note that trace thickness, trace length, and other physical properties affect the resulting inductance.
- FIG. 10 is a schematic block diagram of another embodiment of a power harvesting module 46 that includes a plurality of on-chip air core inductors 70 , a plurality of switching units (S), a rectifying circuit 66 , a capacitor, and a switch controller 72 .
- the inductors 70 may each having an inductance of a few nano-Henries to a few micro-Henries and may be coupled in series, in parallel, or a series parallel combination.
- the MRI transmitter 20 transmits MRI signals 28 at a frequency of 3-45 MHz at a power level of up to 35 KWatts.
- the air core inductors 70 are electromagnetically coupled to generate a voltage from the magnetic and/or electric field generated by the MRI signals 28 .
- the switching module 72 engages the switches via control signals 74 to couple the inductors 70 in series and/or parallel to generate a desired AC voltage.
- the rectifier circuit 66 and the capacitor(s) convert the desired AC voltage into the one or more supply voltages 56 .
- FIG. 11 is a schematic block diagram of another embodiment of a power harvesting module 46 that includes a plurality of Hall effect devices 76 , a power combining module 78 , and a capacitor(s).
- the Hall effect devices 76 generate a voltage based on the constant magnetic field (H) and/or a varying magnetic field.
- the power combining module 78 e.g., a wire, a switch network, a transistor network, a diode network, etc.
- FIG. 12 is a schematic block diagram of another embodiment of a power harvesting module 46 that includes a plurality of piezoelectric devices 82 , a power combining module 78 , and a capacitor(s).
- the piezoelectric devices 82 generate a voltage based on body movement, ultrasound signals, movement of body fluids, etc.
- the power combining module 78 e.g., a wire, a switch network, a transistor network, a diode network, etc.
- the piezoelectric devices 82 may include one or more of a piezoelectric motor, a piezoelectric actuator, a piezoelectric sensor, and/or a piezoelectric high voltage device.
- the various embodiments of the power harvesting module 46 may be combined to generate more power, more supply voltages, etc.
- the embodiment of FIG. 9 may be combined with one or more of the embodiments of FIGS. 11 and 12 .
- FIG. 13 is a schematic block diagram of an embodiment of a power boost module 84 that harvests energy from MRI signals 28 and converts the energy into continuous wave (CW) RF (e.g., up to 3 GHz) and/or MMW (e.g., up to 300 GHz) signals 92 to provide power to the implanted bio-medical units 10 .
- the power boost module 84 sits on the body of the person under test or treatment and includes an electromagnetic power harvesting module 86 and a continuous wave generator 88 .
- the power boosting module 84 can recover significantly more energy than a bio-medical unit 10 since it can be significantly larger.
- a bio-medical unit 10 may have an area of a few millimeters squared while the power boosting module 84 may have an area of a few to tens of centimeters squared.
- FIG. 14 is a schematic block diagram of an embodiment of an electromagnetic (EM)) power harvesting module 86 that includes inductors, diodes (or transistors) and a capacitor.
- the inductors may each be a few mili-Henries such that the power boost module can deliver up to 10's of mili-watts of power.
- FIG. 15 is a schematic block diagram of another embodiment of an electromagnetic (EM)) power harvesting module 86 that includes a plurality of Hall effect devices 76 , a power combining module 78 , and a capacitor. This functions as described with reference to FIG. 11 , but the Hall effect devices 76 can be larger such that more power can be produced. Note that the EM power harvesting module 86 may include a combination of the embodiment of FIG. 14 and the embodiment of FIG. 15 .
- EM electromagnetic
- FIG. 16 is a schematic block diagram of another embodiment of a bio-medical unit 10 that includes a power harvesting module 46 , a communication module 48 , a processing module 50 , memory 52 , and may include one or more functional modules 54 and/or a Hall effect communication module 116 .
- the communication module 48 may include one or more of an ultrasound transceiver 118 (i.e., a receiver and a transmitter), an electromagnetic transceiver 122 , an RF and/or MMW transceiver 120 , and a light source (LED) transceiver 124 .
- ultrasound transceiver 118 i.e., a receiver and a transmitter
- an electromagnetic transceiver 122 i.e., an RF and/or MMW transceiver 120
- a light source (LED) transceiver 124 i.e., a light source
- the one or more functional modules 54 may perform a repair function, an imaging function, and/or a leakage detection function, which may utilize one or more of a motion propulsion module 96 , a camera module 98 , a sampling robotics module 100 , a treatment robotics module 102 , an accelerometer module 104 , a flow meter module 106 , a transducer module 108 , a gyroscope module 110 , a high voltage generator module 112 , a control release robotics module 114 , and/or other functional modules described with reference to one or more other figures.
- the functional modules 54 may be implemented using MEMS technology and/or nanotechnology.
- the camera module 98 may be implemented as a digital image sensor in MEMS technology.
- the Hall effect communication module 116 utilizes variations in the magnetic field and/or electrical field to produce a plus or minus voltage, which can be encoded to convey information.
- the charge applied to one or more Hall effect devices 76 may be varied to produce the voltage change.
- an MRI transmitter 20 and/or gradient unit may modulate a signal on the magnetic field 26 it generates to produce variations in the magnetic field 26 .
- FIG. 17 is a diagram of another embodiment of a system that includes one or more bio-medical units 10 , a transmitter unit 126 , and a receiver unit 128 .
- Each of the bio-medical units 10 includes a power harvesting module 46 , a MMW transceiver 138 , a processing module 50 , and memory 52 .
- the transmitter unit 126 includes a MRI transmitter 130 and a MMW transmitter 132 .
- the receiver unit 128 includes a MRI receiver 134 and a MMW receiver 136 . Note that the MMW transmitter 132 and MMW receiver 136 may be in the same unit (e.g., in the transmitter unit, in the receiver unit, or housed in a separate device).
- the bio-medical unit 10 recovers power from the electromagnetic (EM) signals 146 transmitted by the MRI transmitter 130 and communicates via MMW signals 148 - 150 with the MMW transmitter 132 and MMW receiver 136 .
- the MRI transmitter 130 may be part of a portable MRI device, may be part of a full sized MRI machine, and/or part of a separate device for generating EM signals 146 for powering the bio-medical unit 10 .
- FIG. 18 is a diagram of an example of a communication protocol within the system of FIG. 17 .
- the MRI transmitter 20 transmits RF signals 152 , which have a frequency in the range of 3-45 MHz, at various intervals with varying signal strengths.
- the power harvesting module 46 of the bio-medical units 10 may use these signals to generate power for the bio-medical unit 10 .
- a constant magnetic field and various gradient magnetic fields 154 - 164 are created (one or more in the x dimension Gx, one or more in the y dimension Gy, and one or more in the z direction Gz).
- the power harvesting module 46 of the bio-medical unit 10 may further use the constant magnetic field and/or the varying magnetic fields 154 - 164 to create power for the bio-medical unit 10 .
- the bio-medical unit 10 may communicate 168 with the MMW transmitter 132 and/or MMW receiver 136 .
- the bio-medical unit 10 alternates from generating power to MMW communication in accordance with the conventional transmission-magnetic field pattern of an MRI machine.
- FIG. 19 is a diagram of another embodiment of a system includes one or more bio-medical units 10 , a transmitter unit 126 , and a receiver unit 128 .
- Each of the bio-medical units 10 includes a power harvesting module 46 , an EM transceiver 174 , a processing module 50 , and memory 52 .
- the transmitter unit 126 includes a MRI transmitter 130 and electromagnetic (EM) modulator 170 .
- the receiver unit 128 includes a MRI receiver 134 and an EM demodulator 172 .
- the transmitter unit 126 and receiver unit 128 may be part of a portable MRI device, may be part of a full sized MRI machine, or part of a separate device for generating EM signals for powering the bio-medical unit 10 .
- the MRI transmitter 130 generates an electromagnetic signal that is received by the EM modulator 170 .
- the EM modulator 170 modulates a communication signal on the EM signal to produce an inbound modulated EM signal 176 .
- the EM modulator 170 may modulate (e.g., amplitude modulation, frequency modulation, amplitude shift keying, frequency shift keying, etc.) the magnetic field and/or electric field of the EM signal.
- the EM modulator 170 may modulate the magnetic fields produced by the gradient coils to produce the inbound modulated EM signals 176 .
- the bio-medical unit 10 recovers power from the modulated electromagnetic (EM) signals.
- the EM transceiver 174 demodulates the modulated EM signals 178 to recover the communication signal.
- the EM transceiver 174 modulates an outbound communication signal to produce outbound modulated EM signals 180 .
- the EM transceiver 174 is generating an EM signal that, in air, is modulated on the EM signal transmitted by the transmitter unit 126 .
- the communication in this system is half duplex such that the modulation of the inbound and outbound communication signals is at the same frequency.
- the modulation of the inbound and outbound communication signals are at different frequencies to enable full duplex communication.
- FIG. 20 is a diagram of another example of a communication protocol within the system of FIG. 19 .
- the MRI transmitter 20 transmits RF signals 152 , which have a frequency in the range of 3-45 MHz, at various intervals with varying signal strengths.
- the power harvesting module 46 of the bio-medical units 10 may use these signals to generate power for the bio-medical unit 10 .
- a constant magnetic field and various gradient magnetic fields are created 154 - 164 (one or more in the x dimension Gx, one or more in the y dimension Gy, and one or more in the z direction Gz).
- the power harvesting module 46 of the bio-medical unit 10 may further use the constant magnetic field and/or the varying magnetic fields 154 - 164 to create power for the bio-medical unit 10 .
- the bio-medical unit 10 may communicate via the modulated EM signals 182 .
- the bio-medical unit 10 generates power and communicates in accordance with the conventional transmission-magnetic field pattern of an MRI machine.
- FIG. 21 is a schematic block diagram of an embodiment of a parent bio-medical unit (on the left) communicating with an external unit to coordinates the functions of one or more children bio-medical units 10 (on the right).
- the parent unit includes a communication module 48 for external communications, a communication module 48 for communication with the children units, the processing module 50 , the memory 52 , and the power harvesting module 46 .
- the parent unit may be implemented one or more chips and may in the body or one the body.
- Each of the child units includes a communication module 48 for communication with the parent unit and/or other children units, a MEMS robotics 244 , and the power harvesting module 46 .
- the MEMS robotics 244 may include one or more of a MEMS technology saw, drill, spreader, needle, injection system, and actuator.
- the communication module 48 may support RF and/or MMW inbound and/or outbound signals 60 to the parent unit such that the parent unit may command the child units in accordance with external communications commands.
- the patent bio-medical unit receives a communication from the external source, where the communication indicates a particular function the child units are to perform.
- the parent unit processes the communication and relays relative portions to the child units in accordance with a control mode.
- Each of the child units receives their respective commands and performs the corresponding functions to achieve the desired function.
- FIG. 22 is a schematic block diagram of another embodiment of a plurality of task coordinated bio-medical units 10 including a parent bio-medical unit 10 (on the left) and one or more children bio-medical units 10 (on the right).
- the parent unit may be implemented one or more chips and may in the body or one the body.
- the parent unit may harvest power in conjunction with the power booster 84 .
- the parent unit includes the communication module 48 for external communications, the communication module 48 for communication with the children units, the processing module 50 , the memory 52 , a MEMS electrostatic motor 248 , and the power harvesting module 46 .
- the child unit includes the communication module 48 for communication with the parent unit and/or other children units, a MEMS electrostatic motor 248 , the MEMS robotics 244 , and the power harvesting module 46 . Note that the child unit has fewer components as compared to the parent unit and may be smaller facilitating more applications where smaller bio-medical units 10 enhances their effectiveness.
- the MEMS robotics 244 may include one or more of a MEMS technology saw, drill, spreader, needle, injection system, and actuator.
- the MEMS electrostatic motor 248 may provide mechanical power for the MEMS robotics 244 and/or may provide movement propulsion for the child unit such that the child unit may be positioned to optimize effectiveness.
- the child units may operate in unison to affect a common task. For example, the plurality of child units may operate in unison to saw through a tissue area.
- the child unit communication module 48 may support RF and/or MMW inbound and/or outbound signals 60 to the parent unit such that the parent unit may command the children units in accordance with external communications commands.
- the child unit may determine a control mode and operate in accordance with the control mode, which may be based on one or more of a command from a parent bio-medical unit, external communications, a preprogrammed list, and/or in response to sensor data.
- the control mode may include autonomous, parent (bio-medical unit), server, and/or peer as previously discussed.
- FIG. 23 is a schematic block diagram of an embodiment of an electric stimulation system that includes one or more bio-medical units 10 capable of delivering an electric stimulation current (i.e., an electrotherapy signal).
- Each of the bio-medical unit 10 includes a step-up DC-DC converter 270 , an inverter 272 , a switch 274 , a probe 278 , a nanotechnology or MEMS actuator 276 , the communication module 48 (e.g., for external communications with the communication device and for communications with other bio-medical units), the processing module 50 , the memory 52 , and the power harvesting module 46 .
- the processing module 50 receives a message via the communication 48 that causes the processing module 50 to generate a high voltage stimuli command as the command message.
- the pain management functional module e.g., the MEMS actuator 276 , the switch 274 , and/or the probe 278 ) receives the high voltage stimuli command and, in response thereto, establishes a common ground with another bio-medical unit (e.g., couple via a probe or other electrical means).
- the pain management functional module then produces a high voltage in accordance with the high voltage stimuli command.
- the step-up DC-DC converter 270 converts a lower DC voltage 280 output of the power harvesting module 46 to a higher DC voltage 282 .
- the inverter transforms the higher DC voltage 282 to a higher AC voltage 284 .
- the switch 274 based on the command message, selects one of at least a ground potential, the higher DC voltage 282 , or the higher AC voltage 284 to apply to the probe 278 .
- the probe 278 applies the selected voltage potential to an object adjacent to the bio-medical unit 10 (e.g., a body point such as an acupuncture point, a nerve, a muscle, etc.) when the probe 278 is mechanically extended beyond the outer encasement of the bio-medical unit 10 .
- an object adjacent to the bio-medical unit 10 e.g., a body point such as an acupuncture point, a nerve, a muscle, etc.
- the processing module 50 may control the MEMS actuator 276 to move the probe 278 into position via force 286 to deliver the selected voltage potential or to retract the probe 278 when it is not in use.
- the probe 278 is in contact with the body without mechanical movement.
- the processing module 50 may control the MEMS actuator 276 to move the probe 278 into position to deliver a ground potential voltage potential to simulate an acupuncture application.
- the power harvesting module converts an electromagnetic signal into a supply voltage, which powers the processing module and the pain management functional module.
- the processing module determines a body point for application of pain treatment and a pain treatment duration. For example, the processing module determines the body point to correspond to a ligament with in a person's knee. In addition, the processing module determines the pain treatment duration to be 15 minutes. The processing module that generates a control signal regarding the body point and the pain treatment duration and provides the control signal to the pain management functional module.
- the communication module 48 receives a communication from an external communication device 24 regarding the pain treatment.
- the communication module receives a wireless communication signal from an external communication device 24 and converts it into a baseband or near-baseband signal.
- the processing module converts the baseband or near-baseband signal into a pain treatment command. From the pain treatment command, the processing module determines at least one of the body point and the treatment duration.
- the pain management functional module receives the control signal and, in response thereto, generates an electrotherapy signal, which is directed toward the body point.
- the pain management functional module includes an actuator module 276 , a needle probe 278 , and a high-voltage generator (e.g., 270 and 272 , which will be described in greater detail with reference to FIG. 24 ).
- the actuator module 276 applies a force 286 upon the needle probe 278 such that the needle probe is positioned proximal to the body point.
- the high-voltage generator produces the electrotherapy signal that is applied to the body point via the needle probe 278 .
- the bio-medical unit may further include a cleaning module that is operable to clean the needle probe.
- electro-therapy as applied by the bio medical unit 10 , may be used for such medical treatment as deep brain stimulation for treating neurological diseases, to speed up wound healing, to improve bone healing, to provide pain management, to improve joint range of motion, to treat neuromuscular dysfunction, to improve motor control, to retard muscle atrophy, to improve local blood flow, to improve tissue repair by enhancing microcirculation and protein synthesis, to restore integrity of connective and dermal tissue, to function as a pharmacological agent, improve continence, and/or to relax muscle spasms.
- medical treatment as deep brain stimulation for treating neurological diseases, to speed up wound healing, to improve bone healing, to provide pain management, to improve joint range of motion, to treat neuromuscular dysfunction, to improve motor control, to retard muscle atrophy, to improve local blood flow, to improve tissue repair by enhancing microcirculation and protein synthesis, to restore integrity of connective and dermal tissue, to function as a pharmacological agent, improve continence, and/or to relax muscle spasms.
- FIG. 24 is a schematic diagram of an embodiment of a voltage conversion circuit including a step-up DC-DC converter 270 and an inverter 272 .
- the step-up DC-DC converter 270 includes an input inductor 288 , a pair of switching transistors, a smoothing capacitor, and a control circuit 290 .
- the inductor 288 may be implemented as one or more air core inductors 288 .
- the control circuit 290 operates the switching transistors to interact with the inductor 288 and capacitor to provide the higher DC voltage 282 potential at the output.
- the inverter 272 includes a transformer 294 , a pair of switching transistors, and a control circuit 292 .
- the transformer 294 may be implemented as a 1:1 air core transformer 294 (or other turn ratios) with three single turn coils on different layers with the output between the input coil layers.
- the control circuit 292 operates the switching transistors to interact with the inductance of the transformer 294 to provide an alternating current at the input of the transformer 294 to produce the higher AC voltage 284 potential at the output.
- FIG. 25 is a schematic block diagram of an embodiment of a pain blocking bio-medical unit 10 to provide an amplitude modulated (AM) signal 346 (i.e., an electrotherapy signal) to facilitate gate control of pain.
- the bio-medical unit 10 includes the communication module 48 (e.g., for external communications with the communication device and for communications with other bio-medical units), a MEMS propulsion 348 , the processing module 50 , the memory 52 , the power harvesting module 46 , a frequency adjust 350 , an amplitude modulation 352 , a MMW oscillator 354 , and a power amplifier 356 (PA).
- the communication module 48 e.g., for external communications with the communication device and for communications with other bio-medical units
- MEMS propulsion 348 e.g., for external communications with the communication device and for communications with other bio-medical units
- the processing module 50 e.g., the memory 52 , the power harvesting module 46 , a frequency adjust 350 , an
- the bio-medical unit 10 communicates with other bio-medical units 10 and/or with the communication device 24 to communicate status information and/or commands.
- the bio-medical unit 10 receives a command from the communication device 24 to reposition, adjust the MMW frequency, and transmit MMW signals to mediate pain.
- the communication device 24 may send a command to a plurality of bio-medical units 10 to coordinate the formation of a beam to better pinpoint the pain mediation.
- the processing module 50 controls the MEMS propulsion 348 to reposition the bio-medical unit 10 .
- the processing module 50 determines how to control the frequency adjust 350 and amplitude modulation 352 to affect the pain based on a command, a predetermination, and/or an adaptive algorithm (e.g., that detects local pain).
- the amplitude modulation module 352 generates an amplitude modulation signal based on the control signal and the oscillator 354 generates an oscillation at a frequency much greater than that of the amplitude modulation signal.
- the power amplifier amplifies the oscillation in accordance with the amplitude modulation signal to produce the electrotherapy signal, which is transmitted by an antenna.
- FIG. 26 is a schematic block diagram of an embodiment of a self-cleaning sampling bio-medical unit 10 where a wave based MEMS cleaner 390 facilitates cleaning of a sampling sub-system.
- the bio-medical unit 10 includes the wave based MEMS cleaner 390 for a MEMS sample analyzer 392 , a pipette 394 , a needle 396 , and a MEMS actuator 276 .
- the bio-medical unit 10 also includes the communication module 48 (e.g., for external communications with the communication device and for communications with other bio-medical units), the processing module 50 , the memory 52 , and the power harvesting module 46 .
- the processing module 50 determines when to perform a sampling and cleaning of the sampling sub-system based on a command, a predetermination, and/or an adaptive algorithm (e.g., based on a sample history).
- the processing module 50 may precede each sampling with a cleaning, follow each sampling with a cleaning, or some combination of both.
- the processing module determines to clean the unit 10 , it issues a command to the wave based MEMS cleaner 390 to clean the components of the sampling sub-system.
- the wave based MEMS cleaner 390 may perform the cleaning with one or methods including heating, vibrating, RF energy, laser light, and/or sound waves.
- the bio-medical unit 10 includes a MEMS canister 340 with a cleaning agent that is released during the cleaning sequence and expelled through the needle 396 .
- the processing module determines to collect a biological sample (e.g., blood, tissue, etc.)
- a biological sample e.g., blood, tissue, etc.
- it issues a command to the MEMS actuator 276 , which applies a force 286 to move the needle 396 into the sampling position.
- the needle 396 is exposed to the outside of the bio-medical unit 10 (e.g., extends into the body) to collect the requested sample.
- the pipette 394 moves the sample from the needle 396 to the MEMS sample analyzer 392 .
- the MEMS sample analyzer 392 provides the processing module 50 with sample information that includes blood analysis, pH analysis, temperature, oxygen level, other gas levels, toxin analysis, medication analysis, and/or chemical analysis.
- the processing module 50 processes the sample information to produce processed sample information, which it sends to another bio-medical unit 10 and/or to a communication unit 24 for further processing.
- FIG. 27 is a schematic block diagram of a bio-medical unit 10 that includes a power harvesting module 46 , a communication module 48 , a processing module 50 , memory 52 , an oscillator 355 , an amplifier 357 , and a light emitting module 359 .
- the bio-medical unit 10 may further include a MEMS propulsion module 348 .
- the power harvesting module 46 convert an electromagnetic signal into a supply voltage, which powers the processing module 50 and the pain management functional module (e.g., the oscillator 355 , the amplifier 357 , and the light emitting module 359 ).
- the communication module 48 receives a wireless communication signal from an external communication device 24 and converts it into a baseband or near-baseband signal.
- the processing module converts the baseband or near-baseband signal into a pain treatment command, which includes information regarding a body point and a treatment duration.
- the processing module then generates a control signal based on the body point and the pain treatment duration.
- the pain management functional module receives the control signal and, in response thereto, generates a laser signal.
- the pain management functional module directs the laser signal at the body point.
- the oscillator 355 generates an oscillation in accordance with the control signal.
- the oscillator generates an oscillation having a particular frequency (and/or varying frequency) as dictated by the control signal.
- the amplifier 357 amplifies the oscillation in accordance with the control signal to set intensity of the laser signal.
- the light emitting module 359 generates the laser signal from the oscillation and/or the amplified oscillation.
- the laser signal generated by the bio-medical unit 10 may be used to alter cellular function.
- the alteration of cellular functions may be varied.
- the laser signal may be used for pain relief from rheumatoid arthritis, neck pain, joint disorders, low back pain, wound healing, and/or osteoarthritis.
- the laser signal may reduce pain related to inflammation using dosages in a range of 0.3 to 19 joules per square centimeter.
- FIG. 28 is a schematic block diagram of a bio-medical unit 10 that relieves pain utilizing acupuncture techniques.
- the bio-medical unit 10 includes a power harvesting moduli 46 , a communication module 48 , a processing module 50 , memory 52 , an actuator 276 and a needle probe 278 .
- the power harvesting module 46 convert an electromagnetic signal into a supply voltage, which powers the processing module 50 and the pain management functional module (e.g., actuator 276 and needle probe 278 ).
- the communication module 48 receives a wireless communication signal from an external communication device 24 and converts it into a baseband or near-baseband signal.
- the processing module converts the baseband or near-baseband signal into a pain treatment command, which includes information regarding an acupuncture point and a treatment duration.
- the processing module then generates a control signal based on the acupuncture point and the pain treatment duration.
- the pain management functional module receives the control signal and actuates a needling of the acupuncture point in accordance with the control signal.
- the actuator module 276 applies a force to the needle probe 278 in accordance with the control signal such that the needle probe provides the needling of the acupuncture point.
- the bio-medical unit 10 may further include a cleaning module that cleans the needle probe after the needling of the acupuncture point. Such a cleaning mechanism was described with reference to FIG. 26 .
- the biomedical unit includes a plurality of pain treatment functional modules to needle a plurality of acupuncture points.
- the processing module generates a plurality of control signals that identify a plurality of acupuncture points and a plurality of treatment durations.
- the pain management module further includes a high-voltage generator that generates an electrotherapy signal from the supply voltage and transmits the electrotherapy signal via the needle probe.
- acupuncture points exist on meridians that correspond to blood flow within the body.
- acupuncture points may lie where local pain exists, which may result from a stagnation of blood.
- acupuncture points may lie along the feedback pathways of the cerebral cortex, which can be used to reduce pain.
- the terms “substantially” and “approximately” provides an industry-accepted tolerance for its corresponding term and/or relativity between items. Such an industry-accepted tolerance ranges from less than one percent to fifty percent and corresponds to, but is not limited to, component values, integrated circuit process variations, temperature variations, rise and fall times, and/or thermal noise. Such relativity between items ranges from a difference of a few percent to magnitude differences.
- the term(s) “coupled to” and/or “coupling” and/or includes direct coupling between items and/or indirect coupling between items via an intervening item (e.g., an item includes, but is not limited to, a component, an element, a circuit, and/or a module) where, for indirect coupling, the intervening item does not modify the information of a signal but may adjust its current level, voltage level, and/or power level.
- an intervening item e.g., an item includes, but is not limited to, a component, an element, a circuit, and/or a module
- inferred coupling i.e., where one element is coupled to another element by inference
- the term “operable to” indicates that an item includes one or more of power connections, input(s), output(s), etc., to perform one or more its corresponding functions and may further include inferred coupling to one or more other items.
- the term “associated with”, includes direct and/or indirect coupling of separate items and/or one item being embedded within another item.
- the term “compares favorably”, indicates that a comparison between two or more items, signals, etc., provides a desired relationship. For example, when the desired relationship is that signal 1 has a greater magnitude than signal 2 , a favorable comparison may be achieved when the magnitude of signal 1 is greater than that of signal 2 or when the magnitude of signal 2 is less than that of signal 1 .
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Abstract
Description
- This patent application is claiming priority under 35 USC §119 to a provisionally filed patent application entitled BIO-MEDICAL UNIT AND APPLICATIONS THEREOF, having a provisional filing date of Sep. 30, 2009, and a provisional Ser. No. 61/247,060.
- Not Applicable
- Not Applicable
- 1. Technical Field of the Invention
- This invention relates generally to medical equipment and more particularly to wireless medical equipment.
- 2. Description of Related Art
- As is known, there is a wide variety of medical equipment that aids in the diagnosis, monitoring, and/or treatment of patients' medical conditions. For instances, there are diagnostic medical devices, therapeutic medical devices, life support medical devices, medical monitoring devices, medical laboratory equipment, etc. As specific exampled magnetic resonance imaging (MRI) devices produce images that illustrate the internal structure and function of a body.
- The advancement of medical equipment is in step with the advancements of other technologies (e.g., radio frequency identification (RFID), robotics, etc.). Recently, RFID technology has been used for in vitro use to store patient information for easy access. While such in vitro applications have begun, the technical advancement in this area is in its infancy.
- The present invention is directed to apparatus and methods of operation that are further described in the following Brief Description of the Drawings, the Detailed Description of the Invention, and the claims. Other features and advantages of the present invention will become apparent from the following detailed description of the invention made with reference to the accompanying drawings.
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FIG. 1 is a diagram of an embodiment of a system in accordance with the present invention; -
FIG. 2 is a diagram of another embodiment of a system in accordance with the present invention; -
FIG. 3 is a diagram of an embodiment of an artificial body part including one or more bio-medical units in accordance with the present invention; -
FIG. 4 is a schematic block diagram of an embodiment of an artificial body part in accordance with the present invention; -
FIG. 5 is a diagram of another embodiment of a system in accordance with the present invention; -
FIG. 6 is a diagram of another embodiment of a system in accordance with the present invention; -
FIG. 7 is a diagram of another embodiment of a system in accordance with the present invention; -
FIG. 8 is a schematic block diagram of an embodiment of a bio-medical unit in accordance with the present invention; -
FIG. 9 is a schematic block diagram of an embodiment of a power harvesting module in accordance with the present invention; -
FIG. 10 is a schematic block diagram of another embodiment of a power harvesting module in accordance with the present invention; -
FIG. 11 is a schematic block diagram of another embodiment of a power harvesting module in accordance with the present invention; -
FIG. 12 is a schematic block diagram of another embodiment of a power harvesting module in accordance with the present invention; -
FIG. 13 is a schematic block diagram of an embodiment of a power boost module in accordance with the present invention; -
FIG. 14 is a schematic block diagram of an embodiment of an electromagnetic (EM)) power harvesting module in accordance with the present invention; -
FIG. 15 is a schematic block diagram of another embodiment of an electromagnetic (EM)) power harvesting module in accordance with the present invention; -
FIG. 16 is a schematic block diagram of another embodiment of a bio-medical unit in accordance with the present invention; -
FIG. 17 is a diagram of another embodiment of a system in accordance with the present invention; -
FIG. 18 is a diagram of an example of a communication protocol within a system in accordance with the present invention; -
FIG. 19 is a diagram of another embodiment of a system in accordance with the present invention; -
FIG. 20 is a diagram of another example of a communication protocol within a system in accordance with the present invention; -
FIG. 21 is a diagram of an embodiment of a network of bio-medical units that include MEMS robotics in accordance with the present invention; -
FIG. 22 is a diagram of another embodiment of a network of bio-medical units that include MEMS robotics in accordance with the present invention; -
FIG. 23 is a diagram of an embodiment of a network of bio-medical units for facilitating electrical stimulus treatment in accordance with the present invention; -
FIG. 24 is a diagram of an embodiment of power conversion modules in a bio-medical unit ofFIG. 23 in accordance with the present invention; -
FIG. 25 is a diagram of an embodiment of a bio-medical unit facilitating pain blocking in accordance with the present invention; -
FIG. 26 is a diagram of an embodiment of a bio-medical unit including sampling modules in accordance with the present invention; -
FIG. 27 is a diagram of another embodiment of a bio-medical unit facilitating pain blocking in accordance with the present invention; and -
FIG. 28 is a diagram of another embodiment of a bio-medical unit facilitating pain blocking in accordance with the present invention. -
FIG. 1 is a diagram of an embodiment of a system that includes a plurality ofbio-medical units 10 embedded within a body and/or placed on the surface of the body to facilitate diagnosis, treatment, and/or data collections. Each of thebio-medical units 10 is a passive device (e.g., it does not include a power source (e.g., a battery)) and, as such, includes a power harvesting module. Thebio-medical units 10 may also include one or more of memory, a processing module, and functional modules. Alternatively, or in addition to, each of thebio-medical units 10 may include a rechargeable power source. - In operation, a
transmitter 12 emitselectromagnetic signals 16 that pass through the body and are received by areceiver 14. Thetransmitter 12 andreceiver 14 may be part of a piece of medical diagnostic equipment (e.g., magnetic resonance imaging (MRI), X-ray, etc.) or independent components for stimulating and communicating with the network of bio-medical units in and/or on a body. One or more of thebio-medical units 10 receives the transmittedelectromagnetic signals 16 and generates a supply voltage therefrom. Examples of this will be described in greater detail with reference toFIGS. 8-12 . - Embedded within the electromagnetic signals 16 (e.g., radio frequency (RF) signals, millimeter wave (MMW) signals, MRI signals, etc.) or via separate signals, the
transmitter 12 communicates with one or more of thebio-medical units 10. For example, theelectromagnetic signals 16 may have a frequency in the range of a few MHz to 900 MHz and the communication with thebio-medical units 10 is modulated on theelectromagnetic signals 16 at a much higher frequency (e.g., 5 GHz to 300 GHz). As another example, the communication with thebio-medical units 10 may occur during gaps (e.g., per protocol of medical equipment or injected for communication) of transmitting theelectromagnetic signals 16. As another example, the communication with thebio-medical units 10 occurs in a different frequency band and/or using a different transmission medium (e.g., use RF or MMW signals when the magnetic field of the electromagnetic signals are dominate, use ultrasound signals when theelectromagnetic signals 16 are RF and/or MMW signals, etc.). - One or more of the
bio-medical units 10 receives thecommunication signals 18 and processes them accordingly. The communication signals 18 may be instructions to collect data, to transmit collected data, to move the unit's position in the body, to perform a function, to administer a treatment, etc. If the receivedcommunication signals 18 require a response, thebio-medical unit 10 prepares an appropriate response and transmits it to thereceiver 14 using a similar communication convention used by thetransmitter 12. -
FIG. 2 is a diagram of another embodiment of a system that includes a plurality ofbio-medical units 10 embedded within a body and/or placed on the surface of the body to facilitate diagnosis, treatment, and/or data collections. Each of thebio-medical units 10 is a passive device and, as such, includes a power harvesting module. Thebio-medical units 10 may also include one or more of memory, a processing module, and functional modules. In this embodiment, the person is placed in an MRI machine (fixed or portable) that generates amagnetic field 26 through which theMRI transmitter 20 transmits MRI signals 28 to theMRI receiver 22. - One or more of the
bio-medical units 10 powers itself by harvesting energy from themagnetic field 26 or changes thereof as produced by gradient coils, from the magnetic fields of the MRI signals 28, from the electrical fields of the MRI signals 28, and/or from the electromagnetic aspects of the MRI signals 28. Aunit 10 converts the harvested energy into a supply voltage that supplies other components of the unit (e.g., a communication module, a processing module, memory, a functional module, etc.). - A
communication device 24 communicates data and/orcontrol communications 30 with one or more of thebio-medical units 10 over one or more wireless links. Thecommunication device 24 may be a separate device from the MRI machine or integrated into the MRI machine. For example, thecommunication device 24, whether integrated or separate, may be a cellular telephone, a computer with a wireless interface (e.g., a WLAN station and/or access point, Bluetooth, a proprietary protocol, etc.), etc. A wireless link may be one or more frequencies in the ISM band, in the 60 GHz frequency band, the ultrasound frequency band, and/or other frequency bands that supports one or more communication protocols (e.g., data modulation schemes, beamforming, RF or MMW modulation, encoding, error correction, etc.). - The composition of the
bio-medical units 10 includes non-ferromagnetic materials (e.g., paramagnetic or diamagnetic) and/or metal alloys that are minimally affected by an externalmagnetic field 26. In this regard, the units harvest power from the MRI signals 28 and communicate using RF and/or MMW electromagnetic signals with negligible chance of encountering the projectile or missile effect of implants that include ferromagnetic materials. -
FIG. 3 is a diagram of an embodiment of anartificial body part 32 including one or morebio-medical units 10 that may be surgically implanted into a body. Theartificial body part 32 may be a pace maker, a breast implant, a joint replacement, an artificial bone, splints, fastener devices (e.g., screws, plates, pins, sutures, etc.), artificial organ, etc. Theartificial body part 32 may be permanently embedded in the body or temporarily embedded into the body. -
FIG. 4 is a schematic block diagram of an embodiment of anartificial body part 32 that includes one or morebio-medical units 10. For instance, onebio-medical unit 10 may be used to detect infections, the body's acceptance of theartificial body part 32, measure localized body temperature, monitor performance of theartificial body part 32, and/or data gathering for other diagnostics. Anotherbio-medical unit 10 may be used for deployment of treatment (e.g., disperse medication, apply electrical stimulus, apply RF radiation, apply laser stimulus, etc.). Yet anotherbio-medical unit 10 may be used to adjust the position of theartificial body part 32 and/or a setting of theartificial body part 32. For example, abio-medical unit 10 may be used to mechanically adjust the tension of a splint, screws, etc. As another example, abio-medical unit 10 may be used to adjust an electrical setting of theartificial body part 32. -
FIG. 5 is a diagram of another embodiment of a system that includes a plurality ofbio-medical units 10 and one ormore communication devices 24 coupled to a wide area network (WAN) communication device 34 (e.g., a cable modem, DSL modem, base station, access point, hot spot, etc.). TheWAN communication device 34 is coupled to a network 42 (e.g., cellular telephone network, internet, etc.), which has coupled to it a plurality ofremote monitors 36, a plurality ofdatabases 40, and a plurality ofcomputers 38. Thecommunication device 24 includes a processing module and a wireless transceiver module (e.g., one or more transceivers) and may function similarly tocommunication module 48 as described inFIG. 8 , - In this system, one or more
bio-medical units 10 are implanted in, or affixed to, a host body (e.g., a person, an animal, genetically grown tissue, etc.). As previously discussed and will be discussed in greater detail with reference to one or more of the following figures, a bio-medical unit includes a power harvesting module, a communication module, and one or more functional modules. The power harvesting module operable to produce a supply voltage from a received electromagnetic power signal (e.g., theelectromagnetic signal 16 ofFIGS. 1 and 2 , the MRI signals of one or more the subsequent figures). The communication module and the at least one functional module are powered by the supply voltage. - In an example of operation, the communication device 24 (e.g., integrated into an MRI machine, a cellular telephone, a computer with a wireless interface, etc.) receives a downstream WAN signal from the
network 42 via theWAN communication device 34. The downstream WAN signal may be generated by aremote monitoring device 36, a remote diagnostic device (e.g.,computer 38 performing a remote diagnostic function), a remote control device (e.g.,computer 38 performing a remote control function), and/or a medical record storage device (e.g., database 40). - The
communication device 24 converts the downstream WAN signal into a downstream data signal. For example, thecommunication device 24 may convert the downstream WAN signal into a symbol stream in accordance with one or more wireless communication protocols (e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.). Thecommunication device 24 may convert the symbol stream into the downstream data signal using the same or a different wireless communication protocol. - Alternatively, the
communication device 24 may convert the symbol stream into data that it interprets to determine how to structure the communication with thebio-medical unit 10 and/or what data (e.g., instructions, commands, digital information, etc.) to include in the downstream data signal. Having determined how to structure and what to include in the downstream data signal, thecommunication device 24 generates the downstream data signal in accordance with one or more wireless communication protocols. As yet another alternative, thecommunication device 24 may function as a relay, which provides the downstream WAN signal as the downstream data signal to the one or morebio-medical units 10. - When the
communication device 24 has (and/or is processing) the downstream data signal to send to the bio-medical unit, it sets up a communication with the bio-medical unit. The set up may include identifying the particular bio-medical unit(s), determining the communication protocol used by the identified bio-medical unit(s), sending a signal to an electromagnetic device (e.g., MRI device, etc.) to request that it generates the electromagnetic power signal to power the bio-medical unit, and/or initiate a communication in accordance with the identified communication protocol. As an alternative to requesting a separate electromagnetic device to create the electromagnetic power signal, the communication device may include an electromagnetic device to create the electromagnetic power signal. - Having set up the communication, the
communication device 24 wirelessly communicates the downstream data signal to the communication module of thebio-medical unit 10. The functional module of thebio-medical unit 10 processes the downstream data contained in the downstream data signal to perform a bio-medical functional, to store digital information contained in the downstream data, to administer a treatment (e.g., administer a medication, apply laser stimulus, apply electrical stimulus, etc.), to collect a sample (e.g., blood, tissue, cell, etc.), to perform a micro electro-mechanical function, and/or to collect data. For example, the bio-medical function may include capturing a digital image, capturing a radio frequency (e.g., 300 MHz to 300 GHz) radar image, an ultrasound image, a tissue sample, and/or a measurement (e.g., blood pressure, temperature, pulse, blood-oxygen level, blood sugar level, etc.). - When the downstream data requires a response, the functional module performs a bio-medical function to produce upstream data. The communication module converts the upstream data into an upstream data signal in accordance with the one or more wireless protocols. The
communication device 24 converts the upstream data signal into an upstream wide area network (WAN) signal and transmits it to a remote diagnostic device, a remote control device, and/or a medical record storage device. In this manner, a person(s) operating the remote monitors 36 may view images and/or thedata 30 gathered by thebio-medical units 10. This enables a specialist to be consulted without requiring the patient to travel to the specialist's office. - In another example of operation, one or more of the
computers 38 may communicate with thebio-medical units 10 via thecommunication device 24, theWAN communication device 34, and thenetwork 42. In this example, thecomputer 36 may providecommands 30 to one or more of thebio-medical units 10 to gather data, to dispense a medication, to move to a new position in the body, to perform a mechanical function (e.g., cut, grasp, drill, puncture, stitch, patch, etc.), etc. As such, thebio-medical units 10 may be remotely controlled via one or more of thecomputers 36. - In another example of operation, one or more of the
bio-medical units 10 may read and/or write data from or to one or more of thedatabases 40. For example, data (e.g., a blood sample analysis) generated by one or more of thebio-medical units 10 may be written to one of thedatabases 40. Thecommunication device 24 and/or one of thecomputers 36 may control the writing of data to or the reading of data from the database(s) 40. The data may further include medical records, medical images, prescriptions, etc. -
FIG. 6 is a diagram of another embodiment of a system that includes a plurality ofbio-medical units 10. In this embodiment, thebio-medical units 10 can communicate with each other directly and/or communicate with thecommunication device 24 directly. The communication medium may be an infrared channel(s), an RF channel(s), a MMW channel(s), and/or ultrasound. The units may use a communication protocol such as token passing, carrier sense, time division multiplexing, code division multiplexing, frequency division multiplexing, etc. -
FIG. 7 is a diagram of another embodiment of a system that includes a plurality ofbio-medical units 10. In this embodiment, one of thebio-medical units 44 functions as an access point for the other units. As such, the designatedunit 44 routes communications between theunits 10 and between one ormore units 10 and thecommunication device 24. The communication medium may be an infrared channel(s), an RF channel(s), a MMW channel(s), and/or ultrasound. Theunits 10 may use a communication protocol such as token passing, carrier sense, time division multiplexing, code division multiplexing, frequency division multiplexing, etc. -
FIG. 8 is a schematic block diagram of an embodiment of abio-medical unit 10 that includes apower harvesting module 46, acommunication module 48, aprocessing module 50,memory 52, and one or morefunctional modules 54. Theprocessing module 50 may be a single processing device or a plurality of processing devices. Such a processing device may be a microprocessor, micro-controller, digital signal processor, microcomputer, central processing unit, field programmable gate array, programmable logic device, state machine, logic circuitry, analog circuitry, digital circuitry, and/or any device that manipulates signals (analog and/or digital) based on hard coding of the circuitry and/or operational instructions. Theprocessing module 50 may have an associatedmemory 52 and/or memory element, which may be a single memory device, a plurality of memory devices, and/or embedded circuitry of the processing module. Such amemory device 52 may be a read-only memory, random access memory, volatile memory, non-volatile memory, static memory, dynamic memory, flash memory, cache memory, and/or any device that stores digital information. Note that if theprocessing module 50 includes more than one processing device, the processing devices may be centrally located (e.g., directly coupled together via a wired and/or wireless bus structure) or may be distributedly located (e.g., cloud computing via indirect coupling via a local area network and/or a wide area network). Further note that when theprocessing module 50 implements one or more of its functions via a state machine, analog circuitry, digital circuitry, and/or logic circuitry, the memory and/or memory element storing the corresponding operational instructions may be embedded within, or external to, the circuitry comprising the state machine, analog circuitry, digital circuitry, and/or logic circuitry. Still further note that, the memory element stores, and the processing module executes, hard coded and/or operational instructions corresponding to at least some of the steps and/or functions illustrated inFIGS. 1-26 . - The
power harvesting module 46 may generate one or more supply voltages 56 (Vdd) from a power source signal (e.g., one or more of MRIelectromagnetic signals 16,magnetic fields 26, RF signals, MMW signals, ultrasound signals, light signals, and body motion). Thepower harvesting module 46 may be implemented as disclosed in U.S. Pat. No. 7,595,732 to generate one or more supply voltages from an RF signal. Thepower harvesting module 46 may be implemented as shown in one or moreFIGS. 9-11 to generate one ormore supply voltages 56 from anMRI signal 28 and/ormagnetic field 26. Thepower harvesting module 46 may be implemented as shown inFIG. 12 to generate one ormore supply voltage 56 from body motion. Regardless of how the power harvesting module generates the supply voltage(s), the supply voltage(s) are used to power thecommunication module 48, theprocessing module 50, thememory 52, and/or thefunctional modules 54. - In an example of operation, a receiver section of the
communication module 48 receives an inboundwireless communication signal 60 and converts it into an inbound symbol stream. For example, the receiver section amplifies an inbound wireless (e.g., RF or MMW) signal 60 to produce an amplified inbound RF or MMW signal. The receiver section may then mix in-phase (I) and quadrature (Q) components of the amplified inbound RF or MMW signal with in-phase and quadrature components of a local oscillation to produce a mixed I signal and a mixed Q signal. The mixed I and Q signals are combined to produce an inbound symbol stream. In this embodiment, the inbound symbol may include phase information (e.g., +/−Δθ [phase shift] and/or θ(t) [phase modulation]) and/or frequency information (e.g., +/−Δf [frequency shift] and/or f(t) [frequency modulation]). In another embodiment and/or in furtherance of the preceding embodiment, the inbound RF or MMW signal includes amplitude information (e.g., +/−ΔA [amplitude shift] and/or A(t) [amplitude modulation]). To recover the amplitude information, the receiver section includes an amplitude detector such as an envelope detector, a low pass filter, etc. - The
processing module 50 converts the inbound symbol stream into inbound data and generates a command message based on the inbound data. The command message may instruction one or more of the functional modules to perform one or more electro-mechanical functions of gathering data (e.g., imaging data, flow monitoring data), dispensing a medication, moving to a new position in the body, performing a mechanical function (e.g., cut, grasp, drill, puncture, stitch, patch, etc.), dispensing a treatment, collecting a biological sample, etc. - To convert the inbound symbol stream into the inbound data (e.g., voice, text, audio, video, graphics, etc.), the
processing module 50 may perform one or more of: digital intermediate frequency to baseband conversion, time to frequency domain conversion, space-time-block decoding, space-frequency-block decoding, demodulation, frequency spread decoding, frequency hopping decoding, beamforming decoding, constellation demapping, deinterleaving, decoding, depuncturing, and/or descrambling. Such a conversion is typically prescribed by one or more wireless communication standards (e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.). - The
processing module 50 provides the command message to one or more of the micro-electromechanicalfunctional modules 54. Thefunctional module 54 performs an electro-mechanical function within a hosting body in accordance with the command message. Such an electro-mechanical function includes at least one of data gathering (e.g., image, flow monitoring), motion, repairs, dispensing medication, biological sampling, diagnostics, applying laser treatment, applying ultrasound treatment, grasping, sawing, drilling, providing an electronic stimulus etc. Note that thefunctional modules 54 may be implemented using nanotechnology and/or microelectronic mechanical systems (MEMS) technology. - When requested per the command message (e.g. gather data and report the data), the micro electro-mechanical
functional module 54 generates an electro-mechanical response based on the performing the electro-mechanical function. For example, the response may be data (e.g., heart rate, blood sugar levels, temperature, blood flow rate, image of a body object, etc.), a biological sample (e.g., blood sample, tissue sample, etc.), acknowledgement of performing the function (e.g., acknowledge a software update, storing of data, etc.), and/or any appropriate response. The micro electro-mechanicalfunctional module 54 provides the response to theprocessing module 50. - The
processing module 50 converts the electro-mechanical response into an outbound symbol stream, which may be done in accordance with one or more wireless communication standards (e.g., GSM, CDMA, WCDMA, HSUPA, HSDPA, WiMAX, EDGE, GPRS, IEEE 802.11, Bluetooth, ZigBee, universal mobile telecommunications system (UMTS), long term evolution (LTE), IEEE 802.16, evolution data optimized (EV-DO), etc.). Such a conversion includes one or more of: scrambling, puncturing, encoding, interleaving, constellation mapping, modulation, frequency spreading, frequency hopping, beamforming, space-time-block encoding, space-frequency-block encoding, frequency to time domain conversion, and/or digital baseband to intermediate frequency conversion. - A transmitter section of the
communication module 48 converts an outbound symbol stream into an outbound RF orMMW signal 60 that has a carrier frequency within a given frequency band (e.g., 900 MHz, 2.5 GHz, 5 GHz, 57-66 GHz, etc.). In an embodiment, this may be done by mixing the outbound symbol stream with a local oscillation to produce an up-converted signal. One or more power amplifiers and/or power amplifier drivers amplifies the up-converted signal, which may be RF or MMW bandpass filtered, to produce the outbound RF orMMW signal 60. In another embodiment, the transmitter section includes an oscillator that produces an oscillation. The outbound symbol stream provides phase information (e.g., +/−Δθ [phase shift] and/or θ(t) [phase modulation]) that adjusts the phase of the oscillation to produce a phase adjusted RF or MMW signal, which is transmitted as theoutbound RF signal 60. In another embodiment, the outbound symbol stream includes amplitude information (e.g., A(t) [amplitude modulation]), which is used to adjust the amplitude of the phase adjusted RF or MMW signal to produce the outbound RF orMMW signal 60. - In yet another embodiment, the transmitter section includes an oscillator that produces an oscillation. The outbound symbol provides frequency information (e.g., +/−Δf [frequency shift] and/or f(t) [frequency modulation]) that adjusts the frequency of the oscillation to produce a frequency adjusted RF or MMW signal, which is transmitted as the outbound RF or
MMW signal 60. In another embodiment, the outbound symbol stream includes amplitude information, which is used to adjust the amplitude of the frequency adjusted RF or MMW signal to produce the outbound RF orMMW signal 60. In a further embodiment, the transmitter section includes an oscillator that produces an oscillation. The outbound symbol provides amplitude information (e.g., +/−ΔA [amplitude shift] and/or A(t) [amplitude modulation) that adjusts the amplitude of the oscillation to produce the outbound RF orMMW signal 60. - Note that the
bio-medical unit 10 may be encapsulated by an encapsulate 58 that is non-toxic to the body. For example, the encapsulate 58 may be a silicon based product, a non-ferromagnetic metal alloy (e.g., stainless steel), etc. As another example, the encapsulate 58 may include a spherical shape and have a ferromagnetic liner that shields the unit from a magnetic field and to offset the forces of the magnetic field. Further note that thebio-medical unit 10 may be implemented on a single die that has an area of a few millimeters or less. The die may be fabricated in accordance with CMOS technology, Gallium-Arsenide technology, and/or any other integrated circuit die fabrication process. - In another example of operation, one of the
functional modules 54 functions as a first micro-electro mechanical module and another one of thefunctions modules 54 functions as a second micro-electro mechanical module. In this example, the bio-medical unit is implanted into a host body (e.g., a person, an animal, a reptile, etc.) at a position proximal to a body object to be monitored and/or have an image taken thereof. For example, the body object may be a vein, an artery, an organ, a cyst (or other growth), etc. As a specific example, the bio-medical unit may be positioned approximately parallel to the flow of blood in a vein, artery, and/or the heart. - When powered by the supply voltage, the first micro-electro mechanical module generates and transmits a wireless signal at, or around, the body object. The second micro-electro mechanical module receives a representation of the wireless signal (e.g., a reflection of the wireless signal, a refraction of the wireless signal, or a determined absorption of the wireless signal). Note that the wireless signal may be an ultrasound signal, a radio frequency signal, and/or a millimeter wave signal.
- The
processing module 50 may coordinate the transmitting of the wireless signal and the receiving of the representation of the wireless signal. For example, the processing module may receive, via the communication module, a command to enable the transmitting of the wireless signal (e.g., an ultrasound signal) and the receiving of the representation of the wireless signal. In response, the processing module generates a control signal that it provides to the first micro-electro mechanical module to enable it to transmit the wireless signal. - In addition, the processing module may generate flow monitoring data based on the second micro-electro mechanical module receiving of the representation of the wireless signal. As a specific example, the processing module calculates a fluid flow rate based on phase shifting and/or frequency shifting between the transmitting of the wireless signal and the receiving of the representation of the wireless signal. As another specific example, the processing module gathers phase shifting data and/or frequency shifting data based on the transmitting of the wireless signal and the receiving of the representation of the wireless signal.
- The processing module may further generate imaging data based on the second micro-electro mechanical module receiving the representation of the wireless signal. As a specific example, the processing module calculates an image of the body object based absorption of the wireless signal by the body object and/or vibration of the body object. As another specific example, the processing module gathers data regarding the absorption of the wireless signal by the body object and/or of the vibration of the body object.
- While the preceding examples of a bio-medical unit including first and second micro-electro mechanical modules for transmitting and receiving wireless signals (e.g., ultrasound, RF, MMW, etc.), a bio-medical unit may include one or the other module. For example, a bio-medical unit may include a micro-electro mechanical module for transmitting a wireless signal, where the receiver is external to the body or in another bio-medical unit. As another example, a bio-medical unit may include a micro-electro mechanical module for receiving a representation of a wireless signal, where the transmitter is external to the body or another bio-medical unit.
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FIG. 9 is a schematic block diagram of an embodiment of apower harvesting module 46 that includes an array of on-chipair core inductors 64, a rectifyingcircuit 66, capacitors, and aregulation circuit 68. Theinductors 64 may each having an inductance of a few nano-Henries to a few micro-Henries and may be coupled in series, in parallel, or a series parallel combination. - In an example of operation, the
MRI transmitter 20 transmits MRI signals 28 at a frequency of 3-45 MHz at a power level of up to 35 KWatts. Theair core inductors 64 are electromagnetically coupled to generate a voltage from the magnetic and/or electric field generated by the MRI signals 28. Alternatively, or in addition to, theair core inductors 64 may generate a voltage from themagnetic field 26 and changes thereof produced by the gradient coils. The rectifyingcircuit 66 rectifies the AC voltage produced by the inductors to produce a first DC voltage. The regulation circuit generates one or more desiredsupply voltages 56 from the first DC voltage. - The
inductors 64 may be implemented on one more metal layers of the die and include one or more turns per layer. Note that trace thickness, trace length, and other physical properties affect the resulting inductance. -
FIG. 10 is a schematic block diagram of another embodiment of apower harvesting module 46 that includes a plurality of on-chip air core inductors 70, a plurality of switching units (S), a rectifyingcircuit 66, a capacitor, and aswitch controller 72. The inductors 70 may each having an inductance of a few nano-Henries to a few micro-Henries and may be coupled in series, in parallel, or a series parallel combination. - In an example of operation, the
MRI transmitter 20 transmits MRI signals 28 at a frequency of 3-45 MHz at a power level of up to 35 KWatts. The air core inductors 70 are electromagnetically coupled to generate a voltage from the magnetic and/or electric field generated by the MRI signals 28. Theswitching module 72 engages the switches via control signals 74 to couple the inductors 70 in series and/or parallel to generate a desired AC voltage. Therectifier circuit 66 and the capacitor(s) convert the desired AC voltage into the one ormore supply voltages 56. -
FIG. 11 is a schematic block diagram of another embodiment of apower harvesting module 46 that includes a plurality ofHall effect devices 76, apower combining module 78, and a capacitor(s). In an example of operation, theHall effect devices 76 generate a voltage based on the constant magnetic field (H) and/or a varying magnetic field. The power combining module 78 (e.g., a wire, a switch network, a transistor network, a diode network, etc.) combines the voltages of theHall effect devices 76 to produce the one ormore supply voltages 56. -
FIG. 12 is a schematic block diagram of another embodiment of apower harvesting module 46 that includes a plurality ofpiezoelectric devices 82, apower combining module 78, and a capacitor(s). In an example of operation, thepiezoelectric devices 82 generate a voltage based on body movement, ultrasound signals, movement of body fluids, etc. The power combining module 78 (e.g., a wire, a switch network, a transistor network, a diode network, etc.) combines the voltages of theHall effect devices 82 to produce the one ormore supply voltages 56. Note that thepiezoelectric devices 82 may include one or more of a piezoelectric motor, a piezoelectric actuator, a piezoelectric sensor, and/or a piezoelectric high voltage device. - The various embodiments of the
power harvesting module 46 may be combined to generate more power, more supply voltages, etc. For example, the embodiment ofFIG. 9 may be combined with one or more of the embodiments ofFIGS. 11 and 12 . -
FIG. 13 is a schematic block diagram of an embodiment of apower boost module 84 that harvests energy from MRI signals 28 and converts the energy into continuous wave (CW) RF (e.g., up to 3 GHz) and/or MMW (e.g., up to 300 GHz) signals 92 to provide power to the implantedbio-medical units 10. Thepower boost module 84 sits on the body of the person under test or treatment and includes an electromagneticpower harvesting module 86 and acontinuous wave generator 88. In such an embodiment, thepower boosting module 84 can recover significantly more energy than abio-medical unit 10 since it can be significantly larger. For example, abio-medical unit 10 may have an area of a few millimeters squared while thepower boosting module 84 may have an area of a few to tens of centimeters squared. -
FIG. 14 is a schematic block diagram of an embodiment of an electromagnetic (EM))power harvesting module 86 that includes inductors, diodes (or transistors) and a capacitor. The inductors may each be a few mili-Henries such that the power boost module can deliver up to 10's of mili-watts of power. -
FIG. 15 is a schematic block diagram of another embodiment of an electromagnetic (EM))power harvesting module 86 that includes a plurality ofHall effect devices 76, apower combining module 78, and a capacitor. This functions as described with reference toFIG. 11 , but theHall effect devices 76 can be larger such that more power can be produced. Note that the EMpower harvesting module 86 may include a combination of the embodiment ofFIG. 14 and the embodiment ofFIG. 15 . -
FIG. 16 is a schematic block diagram of another embodiment of abio-medical unit 10 that includes apower harvesting module 46, acommunication module 48, aprocessing module 50,memory 52, and may include one or morefunctional modules 54 and/or a Halleffect communication module 116. Thecommunication module 48 may include one or more of an ultrasound transceiver 118 (i.e., a receiver and a transmitter), anelectromagnetic transceiver 122, an RF and/orMMW transceiver 120, and a light source (LED)transceiver 124. Note that examples of the various types ofcommunication modules 48 will be described in greater detail with reference to one or more of the subsequent Figures. - The one or more
functional modules 54 may perform a repair function, an imaging function, and/or a leakage detection function, which may utilize one or more of amotion propulsion module 96, acamera module 98, asampling robotics module 100, atreatment robotics module 102, anaccelerometer module 104, aflow meter module 106, atransducer module 108, agyroscope module 110, a highvoltage generator module 112, a controlrelease robotics module 114, and/or other functional modules described with reference to one or more other figures. Thefunctional modules 54 may be implemented using MEMS technology and/or nanotechnology. For example, thecamera module 98 may be implemented as a digital image sensor in MEMS technology. - The Hall
effect communication module 116 utilizes variations in the magnetic field and/or electrical field to produce a plus or minus voltage, which can be encoded to convey information. For example, the charge applied to one or moreHall effect devices 76 may be varied to produce the voltage change. As another example, anMRI transmitter 20 and/or gradient unit may modulate a signal on themagnetic field 26 it generates to produce variations in themagnetic field 26. -
FIG. 17 is a diagram of another embodiment of a system that includes one or morebio-medical units 10, atransmitter unit 126, and areceiver unit 128. Each of thebio-medical units 10 includes apower harvesting module 46, aMMW transceiver 138, aprocessing module 50, andmemory 52. Thetransmitter unit 126 includes aMRI transmitter 130 and aMMW transmitter 132. Thereceiver unit 128 includes aMRI receiver 134 and aMMW receiver 136. Note that theMMW transmitter 132 andMMW receiver 136 may be in the same unit (e.g., in the transmitter unit, in the receiver unit, or housed in a separate device). - In an example of operation, the
bio-medical unit 10 recovers power from the electromagnetic (EM) signals 146 transmitted by theMRI transmitter 130 and communicates via MMW signals 148-150 with theMMW transmitter 132 andMMW receiver 136. TheMRI transmitter 130 may be part of a portable MRI device, may be part of a full sized MRI machine, and/or part of a separate device for generatingEM signals 146 for powering thebio-medical unit 10. -
FIG. 18 is a diagram of an example of a communication protocol within the system ofFIG. 17 . In this diagram, theMRI transmitter 20 transmits RF signals 152, which have a frequency in the range of 3-45 MHz, at various intervals with varying signal strengths. Thepower harvesting module 46 of thebio-medical units 10 may use these signals to generate power for thebio-medical unit 10. - In addition to the
MRI transmitter 20 transmitting its signal, a constant magnetic field and various gradient magnetic fields 154-164 are created (one or more in the x dimension Gx, one or more in the y dimension Gy, and one or more in the z direction Gz). Thepower harvesting module 46 of thebio-medical unit 10 may further use the constant magnetic field and/or the varying magnetic fields 154-164 to create power for thebio-medical unit 10. - During non-transmission periods of the cycle, the
bio-medical unit 10 may communicate 168 with theMMW transmitter 132 and/orMMW receiver 136. In this regard, thebio-medical unit 10 alternates from generating power to MMW communication in accordance with the conventional transmission-magnetic field pattern of an MRI machine. -
FIG. 19 is a diagram of another embodiment of a system includes one or morebio-medical units 10, atransmitter unit 126, and areceiver unit 128. Each of thebio-medical units 10 includes apower harvesting module 46, anEM transceiver 174, aprocessing module 50, andmemory 52. Thetransmitter unit 126 includes aMRI transmitter 130 and electromagnetic (EM)modulator 170. Thereceiver unit 128 includes aMRI receiver 134 and anEM demodulator 172. Thetransmitter unit 126 andreceiver unit 128 may be part of a portable MRI device, may be part of a full sized MRI machine, or part of a separate device for generating EM signals for powering thebio-medical unit 10. - In an example of operation, the
MRI transmitter 130 generates an electromagnetic signal that is received by theEM modulator 170. The EM modulator 170 modulates a communication signal on the EM signal to produce an inbound modulatedEM signal 176. The EM modulator 170 may modulate (e.g., amplitude modulation, frequency modulation, amplitude shift keying, frequency shift keying, etc.) the magnetic field and/or electric field of the EM signal. In another embodiment, theEM modulator 170 may modulate the magnetic fields produced by the gradient coils to produce the inbound modulated EM signals 176. - The
bio-medical unit 10 recovers power from the modulated electromagnetic (EM) signals. In addition, theEM transceiver 174 demodulates the modulated EM signals 178 to recover the communication signal. For outbound signals, theEM transceiver 174 modulates an outbound communication signal to produce outbound modulated EM signals 180. In this instance, theEM transceiver 174 is generating an EM signal that, in air, is modulated on the EM signal transmitted by thetransmitter unit 126. In one embodiment, the communication in this system is half duplex such that the modulation of the inbound and outbound communication signals is at the same frequency. In another embodiment, the modulation of the inbound and outbound communication signals are at different frequencies to enable full duplex communication. -
FIG. 20 is a diagram of another example of a communication protocol within the system ofFIG. 19 . In this diagram, theMRI transmitter 20 transmits RF signals 152, which have a frequency in the range of 3-45 MHz, at various intervals with varying signal strengths. Thepower harvesting module 46 of thebio-medical units 10 may use these signals to generate power for thebio-medical unit 10. - In addition to the
MRI transmitter 20 transmitting its signal, a constant magnetic field and various gradient magnetic fields are created 154-164 (one or more in the x dimension Gx, one or more in the y dimension Gy, and one or more in the z direction Gz). Thepower harvesting module 46 of thebio-medical unit 10 may further use the constant magnetic field and/or the varying magnetic fields 154-164 to create power for thebio-medical unit 10. - During the transmission periods of the cycle, the
bio-medical unit 10 may communicate via the modulated EM signals 182. In this regard, thebio-medical unit 10 generates power and communicates in accordance with the conventional transmission-magnetic field pattern of an MRI machine. -
FIG. 21 is a schematic block diagram of an embodiment of a parent bio-medical unit (on the left) communicating with an external unit to coordinates the functions of one or more children bio-medical units 10 (on the right). The parent unit includes acommunication module 48 for external communications, acommunication module 48 for communication with the children units, theprocessing module 50, thememory 52, and thepower harvesting module 46. Note that the parent unit may be implemented one or more chips and may in the body or one the body. - Each of the child units includes a
communication module 48 for communication with the parent unit and/or other children units, aMEMS robotics 244, and thepower harvesting module 46. TheMEMS robotics 244 may include one or more of a MEMS technology saw, drill, spreader, needle, injection system, and actuator. Thecommunication module 48 may support RF and/or MMW inbound and/oroutbound signals 60 to the parent unit such that the parent unit may command the child units in accordance with external communications commands. - In an example of operation, the patent bio-medical unit receives a communication from the external source, where the communication indicates a particular function the child units are to perform. The parent unit processes the communication and relays relative portions to the child units in accordance with a control mode. Each of the child units receives their respective commands and performs the corresponding functions to achieve the desired function.
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FIG. 22 is a schematic block diagram of another embodiment of a plurality of task coordinatedbio-medical units 10 including a parent bio-medical unit 10 (on the left) and one or more children bio-medical units 10 (on the right). The parent unit may be implemented one or more chips and may in the body or one the body. The parent unit may harvest power in conjunction with thepower booster 84. - The parent unit includes the
communication module 48 for external communications, thecommunication module 48 for communication with the children units, theprocessing module 50, thememory 52, a MEMSelectrostatic motor 248, and thepower harvesting module 46. The child unit includes thecommunication module 48 for communication with the parent unit and/or other children units, a MEMSelectrostatic motor 248, theMEMS robotics 244, and thepower harvesting module 46. Note that the child unit has fewer components as compared to the parent unit and may be smaller facilitating more applications where smallerbio-medical units 10 enhances their effectiveness. - The
MEMS robotics 244 may include one or more of a MEMS technology saw, drill, spreader, needle, injection system, and actuator. The MEMSelectrostatic motor 248 may provide mechanical power for theMEMS robotics 244 and/or may provide movement propulsion for the child unit such that the child unit may be positioned to optimize effectiveness. The child units may operate in unison to affect a common task. For example, the plurality of child units may operate in unison to saw through a tissue area. - The child
unit communication module 48 may support RF and/or MMW inbound and/oroutbound signals 60 to the parent unit such that the parent unit may command the children units in accordance with external communications commands. The child unit may determine a control mode and operate in accordance with the control mode, which may be based on one or more of a command from a parent bio-medical unit, external communications, a preprogrammed list, and/or in response to sensor data. Note that the control mode may include autonomous, parent (bio-medical unit), server, and/or peer as previously discussed. -
FIG. 23 is a schematic block diagram of an embodiment of an electric stimulation system that includes one or morebio-medical units 10 capable of delivering an electric stimulation current (i.e., an electrotherapy signal). Each of thebio-medical unit 10 includes a step-up DC-DC converter 270, aninverter 272, aswitch 274, aprobe 278, a nanotechnology orMEMS actuator 276, the communication module 48 (e.g., for external communications with the communication device and for communications with other bio-medical units), theprocessing module 50, thememory 52, and thepower harvesting module 46. - In an example of operation, the
processing module 50 receives a message via thecommunication 48 that causes theprocessing module 50 to generate a high voltage stimuli command as the command message. The pain management functional module (e.g., theMEMS actuator 276, theswitch 274, and/or the probe 278) receives the high voltage stimuli command and, in response thereto, establishes a common ground with another bio-medical unit (e.g., couple via a probe or other electrical means). The pain management functional module then produces a high voltage in accordance with the high voltage stimuli command. - For instance, the step-up DC-
DC converter 270 converts alower DC voltage 280 output of thepower harvesting module 46 to ahigher DC voltage 282. The inverter transforms thehigher DC voltage 282 to ahigher AC voltage 284. Theswitch 274, based on the command message, selects one of at least a ground potential, thehigher DC voltage 282, or thehigher AC voltage 284 to apply to theprobe 278. Theprobe 278 applies the selected voltage potential to an object adjacent to the bio-medical unit 10 (e.g., a body point such as an acupuncture point, a nerve, a muscle, etc.) when theprobe 278 is mechanically extended beyond the outer encasement of thebio-medical unit 10. For example, theprocessing module 50 may control the MEMS actuator 276 to move theprobe 278 into position viaforce 286 to deliver the selected voltage potential or to retract theprobe 278 when it is not in use. In another example, theprobe 278 is in contact with the body without mechanical movement. Note that theprocessing module 50 may control the MEMS actuator 276 to move theprobe 278 into position to deliver a ground potential voltage potential to simulate an acupuncture application. - In another example of operation, the power harvesting module converts an electromagnetic signal into a supply voltage, which powers the processing module and the pain management functional module. The processing module determines a body point for application of pain treatment and a pain treatment duration. For example, the processing module determines the body point to correspond to a ligament with in a person's knee. In addition, the processing module determines the pain treatment duration to be 15 minutes. The processing module that generates a control signal regarding the body point and the pain treatment duration and provides the control signal to the pain management functional module.
- In one instance, the
communication module 48 receives a communication from anexternal communication device 24 regarding the pain treatment. For example, the communication module receives a wireless communication signal from anexternal communication device 24 and converts it into a baseband or near-baseband signal. The processing module converts the baseband or near-baseband signal into a pain treatment command. From the pain treatment command, the processing module determines at least one of the body point and the treatment duration. - The pain management functional module receives the control signal and, in response thereto, generates an electrotherapy signal, which is directed toward the body point. For example, the pain management functional module includes an
actuator module 276, aneedle probe 278, and a high-voltage generator (e.g., 270 and 272, which will be described in greater detail with reference toFIG. 24 ). In response to the control signal, theactuator module 276 applies aforce 286 upon theneedle probe 278 such that the needle probe is positioned proximal to the body point. When in that position, the high-voltage generator produces the electrotherapy signal that is applied to the body point via theneedle probe 278. While not shown inFIG. 23 , the bio-medical unit may further include a cleaning module that is operable to clean the needle probe. - In general, electro-therapy, as applied by the bio
medical unit 10, may be used for such medical treatment as deep brain stimulation for treating neurological diseases, to speed up wound healing, to improve bone healing, to provide pain management, to improve joint range of motion, to treat neuromuscular dysfunction, to improve motor control, to retard muscle atrophy, to improve local blood flow, to improve tissue repair by enhancing microcirculation and protein synthesis, to restore integrity of connective and dermal tissue, to function as a pharmacological agent, improve continence, and/or to relax muscle spasms. -
FIG. 24 is a schematic diagram of an embodiment of a voltage conversion circuit including a step-up DC-DC converter 270 and aninverter 272. The step-up DC-DC converter 270 includes aninput inductor 288, a pair of switching transistors, a smoothing capacitor, and acontrol circuit 290. Theinductor 288 may be implemented as one or moreair core inductors 288. Thecontrol circuit 290 operates the switching transistors to interact with theinductor 288 and capacitor to provide thehigher DC voltage 282 potential at the output. - The
inverter 272 includes atransformer 294, a pair of switching transistors, and acontrol circuit 292. Thetransformer 294 may be implemented as a 1:1 air core transformer 294 (or other turn ratios) with three single turn coils on different layers with the output between the input coil layers. Thecontrol circuit 292 operates the switching transistors to interact with the inductance of thetransformer 294 to provide an alternating current at the input of thetransformer 294 to produce thehigher AC voltage 284 potential at the output. -
FIG. 25 is a schematic block diagram of an embodiment of a pain blockingbio-medical unit 10 to provide an amplitude modulated (AM) signal 346 (i.e., an electrotherapy signal) to facilitate gate control of pain. Thebio-medical unit 10 includes the communication module 48 (e.g., for external communications with the communication device and for communications with other bio-medical units), aMEMS propulsion 348, theprocessing module 50, thememory 52, thepower harvesting module 46, a frequency adjust 350, anamplitude modulation 352, aMMW oscillator 354, and a power amplifier 356 (PA). - The
bio-medical unit 10 communicates with otherbio-medical units 10 and/or with thecommunication device 24 to communicate status information and/or commands. For example, thebio-medical unit 10 receives a command from thecommunication device 24 to reposition, adjust the MMW frequency, and transmit MMW signals to mediate pain. In another example, thecommunication device 24 may send a command to a plurality ofbio-medical units 10 to coordinate the formation of a beam to better pinpoint the pain mediation. - The
processing module 50 controls theMEMS propulsion 348 to reposition thebio-medical unit 10. In addition, theprocessing module 50 determines how to control the frequency adjust 350 andamplitude modulation 352 to affect the pain based on a command, a predetermination, and/or an adaptive algorithm (e.g., that detects local pain). - In an example of operation, the
amplitude modulation module 352 generates an amplitude modulation signal based on the control signal and theoscillator 354 generates an oscillation at a frequency much greater than that of the amplitude modulation signal. The power amplifier amplifies the oscillation in accordance with the amplitude modulation signal to produce the electrotherapy signal, which is transmitted by an antenna. -
FIG. 26 is a schematic block diagram of an embodiment of a self-cleaningsampling bio-medical unit 10 where a wave based MEMS cleaner 390 facilitates cleaning of a sampling sub-system. Thebio-medical unit 10 includes the wave based MEMS cleaner 390 for aMEMS sample analyzer 392, apipette 394, aneedle 396, and aMEMS actuator 276. Thebio-medical unit 10 also includes the communication module 48 (e.g., for external communications with the communication device and for communications with other bio-medical units), theprocessing module 50, thememory 52, and thepower harvesting module 46. - The
processing module 50 determines when to perform a sampling and cleaning of the sampling sub-system based on a command, a predetermination, and/or an adaptive algorithm (e.g., based on a sample history). Theprocessing module 50 may precede each sampling with a cleaning, follow each sampling with a cleaning, or some combination of both. - When the processing module determines to clean the
unit 10, it issues a command to the wave based MEMS cleaner 390 to clean the components of the sampling sub-system. The wave based MEMS cleaner 390 may perform the cleaning with one or methods including heating, vibrating, RF energy, laser light, and/or sound waves. In another example, thebio-medical unit 10 includes a MEMS canister 340 with a cleaning agent that is released during the cleaning sequence and expelled through theneedle 396. - When the processing module determines to collect a biological sample (e.g., blood, tissue, etc.), it issues a command to the
MEMS actuator 276, which applies aforce 286 to move theneedle 396 into the sampling position. In this position, theneedle 396 is exposed to the outside of the bio-medical unit 10 (e.g., extends into the body) to collect the requested sample. Thepipette 394 moves the sample from theneedle 396 to theMEMS sample analyzer 392. - The
MEMS sample analyzer 392 provides theprocessing module 50 with sample information that includes blood analysis, pH analysis, temperature, oxygen level, other gas levels, toxin analysis, medication analysis, and/or chemical analysis. Theprocessing module 50 processes the sample information to produce processed sample information, which it sends to anotherbio-medical unit 10 and/or to acommunication unit 24 for further processing. -
FIG. 27 is a schematic block diagram of abio-medical unit 10 that includes apower harvesting module 46, acommunication module 48, aprocessing module 50,memory 52, anoscillator 355, anamplifier 357, and alight emitting module 359. Thebio-medical unit 10 may further include aMEMS propulsion module 348. Thepower harvesting module 46 convert an electromagnetic signal into a supply voltage, which powers theprocessing module 50 and the pain management functional module (e.g., theoscillator 355, theamplifier 357, and the light emitting module 359). - In an example of operation, the
communication module 48 receives a wireless communication signal from anexternal communication device 24 and converts it into a baseband or near-baseband signal. The processing module converts the baseband or near-baseband signal into a pain treatment command, which includes information regarding a body point and a treatment duration. The processing module then generates a control signal based on the body point and the pain treatment duration. - The pain management functional module receives the control signal and, in response thereto, generates a laser signal. The pain management functional module directs the laser signal at the body point. For example, the
oscillator 355 generates an oscillation in accordance with the control signal. For instance, the oscillator generates an oscillation having a particular frequency (and/or varying frequency) as dictated by the control signal. Theamplifier 357 amplifies the oscillation in accordance with the control signal to set intensity of the laser signal. Thelight emitting module 359 generates the laser signal from the oscillation and/or the amplified oscillation. - The laser signal generated by the
bio-medical unit 10 may be used to alter cellular function. By adjusting the wavelength, timing, pulsing, duration, and/or direction of the laser signal the alteration of cellular functions may be varied. In particular, the laser signal may be used for pain relief from rheumatoid arthritis, neck pain, joint disorders, low back pain, wound healing, and/or osteoarthritis. For instance, the laser signal may reduce pain related to inflammation using dosages in a range of 0.3 to 19 joules per square centimeter. -
FIG. 28 is a schematic block diagram of abio-medical unit 10 that relieves pain utilizing acupuncture techniques. Thebio-medical unit 10 includes apower harvesting moduli 46, acommunication module 48, aprocessing module 50,memory 52, anactuator 276 and aneedle probe 278. Thepower harvesting module 46 convert an electromagnetic signal into a supply voltage, which powers theprocessing module 50 and the pain management functional module (e.g.,actuator 276 and needle probe 278). - In an example of operation, the
communication module 48 receives a wireless communication signal from anexternal communication device 24 and converts it into a baseband or near-baseband signal. The processing module converts the baseband or near-baseband signal into a pain treatment command, which includes information regarding an acupuncture point and a treatment duration. The processing module then generates a control signal based on the acupuncture point and the pain treatment duration. - The pain management functional module receives the control signal and actuates a needling of the acupuncture point in accordance with the control signal. For example, the
actuator module 276 applies a force to theneedle probe 278 in accordance with the control signal such that the needle probe provides the needling of the acupuncture point. Note that thebio-medical unit 10 may further include a cleaning module that cleans the needle probe after the needling of the acupuncture point. Such a cleaning mechanism was described with reference toFIG. 26 . - In another example of operation, the biomedical unit includes a plurality of pain treatment functional modules to needle a plurality of acupuncture points. In this example, the processing module generates a plurality of control signals that identify a plurality of acupuncture points and a plurality of treatment durations. In yet another example of operation, the pain management module further includes a high-voltage generator that generates an electrotherapy signal from the supply voltage and transmits the electrotherapy signal via the needle probe.
- The acupuncture points exist on meridians that correspond to blood flow within the body. In addition, acupuncture points may lie where local pain exists, which may result from a stagnation of blood. Further, acupuncture points may lie along the feedback pathways of the cerebral cortex, which can be used to reduce pain.
- As may be used herein, the terms “substantially” and “approximately” provides an industry-accepted tolerance for its corresponding term and/or relativity between items. Such an industry-accepted tolerance ranges from less than one percent to fifty percent and corresponds to, but is not limited to, component values, integrated circuit process variations, temperature variations, rise and fall times, and/or thermal noise. Such relativity between items ranges from a difference of a few percent to magnitude differences. As may also be used herein, the term(s) “coupled to” and/or “coupling” and/or includes direct coupling between items and/or indirect coupling between items via an intervening item (e.g., an item includes, but is not limited to, a component, an element, a circuit, and/or a module) where, for indirect coupling, the intervening item does not modify the information of a signal but may adjust its current level, voltage level, and/or power level. As may further be used herein, inferred coupling (i.e., where one element is coupled to another element by inference) includes direct and indirect coupling between two items in the same manner as “coupled to”. As may even further be used herein, the term “operable to” indicates that an item includes one or more of power connections, input(s), output(s), etc., to perform one or more its corresponding functions and may further include inferred coupling to one or more other items. As may still further be used herein, the term “associated with”, includes direct and/or indirect coupling of separate items and/or one item being embedded within another item. As may be used herein, the term “compares favorably”, indicates that a comparison between two or more items, signals, etc., provides a desired relationship. For example, when the desired relationship is that
signal 1 has a greater magnitude thansignal 2, a favorable comparison may be achieved when the magnitude ofsignal 1 is greater than that ofsignal 2 or when the magnitude ofsignal 2 is less than that ofsignal 1. - The present invention has also been described above with the aid of method steps illustrating the performance of specified functions and relationships thereof. The boundaries and sequence of these functional building blocks and method steps have been arbitrarily defined herein for convenience of description. Alternate boundaries and sequences can be defined so long as the specified functions and relationships are appropriately performed. Any such alternate boundaries or sequences are thus within the scope and spirit of the claimed invention.
- The present invention has been described above with the aid of functional building blocks illustrating the performance of certain significant functions. The boundaries of these functional building blocks have been arbitrarily defined for convenience of description. Alternate boundaries could be defined as long as the certain significant functions are appropriately performed. Similarly, flow diagram blocks may also have been arbitrarily defined herein to illustrate certain significant functionality. To the extent used, the flow diagram block boundaries and sequence could have been defined otherwise and still perform the certain significant functionality. Such alternate definitions of both functional building blocks and flow diagram blocks and sequences are thus within the scope and spirit of the claimed invention. One of average skill in the art will also recognize that the functional building blocks, and other illustrative blocks, modules and components herein, can be implemented as illustrated or by discrete components, application specific integrated circuits, processors executing appropriate software and the like or any combination thereof.
Claims (16)
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US20110077502A1 (en) | 2011-03-31 |
US20110077476A1 (en) | 2011-03-31 |
US20150314116A1 (en) | 2015-11-05 |
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US8526894B2 (en) | 2013-09-03 |
US8923967B2 (en) | 2014-12-30 |
US20110077501A1 (en) | 2011-03-31 |
US20110077716A1 (en) | 2011-03-31 |
US20110077713A1 (en) | 2011-03-31 |
US8254853B2 (en) | 2012-08-28 |
US9081878B2 (en) | 2015-07-14 |
US20110077718A1 (en) | 2011-03-31 |
US20110077715A1 (en) | 2011-03-31 |
US20110077580A1 (en) | 2011-03-31 |
US20110077623A1 (en) | 2011-03-31 |
US20110077719A1 (en) | 2011-03-31 |
US20110077697A1 (en) | 2011-03-31 |
US20110077513A1 (en) | 2011-03-31 |
US20120323088A1 (en) | 2012-12-20 |
US9111021B2 (en) | 2015-08-18 |
US20110077714A1 (en) | 2011-03-31 |
US20110077700A1 (en) | 2011-03-31 |
US20110077459A1 (en) | 2011-03-31 |
US20110077736A1 (en) | 2011-03-31 |
US8489199B2 (en) | 2013-07-16 |
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