US20100049289A1 - Tissue anchor - Google Patents

Tissue anchor Download PDF

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Publication number
US20100049289A1
US20100049289A1 US12558143 US55814309A US2010049289A1 US 20100049289 A1 US20100049289 A1 US 20100049289A1 US 12558143 US12558143 US 12558143 US 55814309 A US55814309 A US 55814309A US 2010049289 A1 US2010049289 A1 US 2010049289A1
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Patent type
Prior art keywords
anchor
electrode
body
tissue
lead
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12558143
Inventor
Robert E. Lund
John Jason Buysman
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AMS Research LLC
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AMS Research LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0558Anchoring or fixation means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

Embodiments of the invention generally relate to an anchor used to secure a position of a device or component relative to internal tissue of a patient and prevent migration of the component relative to the tissue of the patient. In one embodiment, the anchor is combined with an electrode lead that is configured for implantation in a patient. The electrode lead comprises a lead body having a proximal end and a distal end, a stimulating electrode and an anchor. The stimulating electrode is attached to the lead body at the distal end. The anchor is attached to the distal end of the lead body and comprises an anchor body and mesh attached to the anchor body.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    The present application claims the benefit of U.S. provisional patent application Ser. Nos. 61/096,387 filed Sep. 12, 2008 and 61/160,765 filed Mar. 17, 2009; and the present application is a continuation-in-part of U.S. application Ser. No. 12/170,582 filed Jul. 10, 2008, which in turn claims the benefit of U.S. provisional patent application Ser. No. 60/948,908, filed Jul. 10, 2007. The content of each of the above-referenced applications, is hereby incorporated by reference in its entirety.
  • FIELD OF THE INVENTION
  • [0002]
    Embodiments of the present invention generally relate to an anchor that facilitates securing devices or components to internal tissue of a patient and preventing migration of the devices or components from their intended location relative to the tissue of the patient.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Implantable electronic stimulator devices, such as neuromuscular stimulation devices, have been disclosed for use in the treatment of various pelvic conditions, such as urinary incontinence, fecal incontinence and sexual dysfunction. Such devices generally include one or more electrodes that are coupled to a control unit by electrode leads. Electrical signals are applied to the desired pelvic tissue of the patient through the electrode leads in order to treat the condition of the patient. The electrode leads are typically secured to the tissue using an anchor in the form of a helical coil. Exemplary implantable electronic stimulator devices and uses of the devices are disclosed in U.S. Pat. Nos. 6,354,991, 6,652,449, 6,712,772 and 6,862,480, each of which is hereby incorporated by reference in its entirety.
  • [0004]
    Urinary incontinence in women has been treated by a surgical method involving the placement of a sling to stabilize or support the bladder neck or urethra of the patient. Varieties of sling procedures are described in U.S. Pub. No. 2002-016382 A1, which is incorporated herein by reference in its entirety. One type of sling procedure is a pubovaginal sling procedure, which is a minimally invasive surgical method involving the placement (e.g. by the use of a Stamey needle or other ligature carrier) of a sling to stabilize or support the bladder neck or urethra. This procedure does not utilize bone anchors. Rather the sling is anchored in the abdominal or rectus fascia.
  • [0005]
    U.S. Pub. No. 2007-0260288 A1, which is incorporated herein by reference in its entirety, generally describes a combination of the above devices. One or more electrodes are attached to a mechanical support, such as a sling, that supports a portion of the urethra of the patient. The electrodes are configured to contact tissue of the patient when the mechanical support is implanted in the patient. A control unit drives the electrodes to apply a current to the tissue that treats a pelvic condition of the patient.
  • [0006]
    The above-describe devices utilize anchors to secure components of the devices, such as electrode leads and/or mechanical supports, in tissue of the patient. It is desirable, for example, that such anchors prevent relative movement between the anchor and the tissue in which the anchor in embedded, are easy to install in the tissue, avoid damaging the tissue during the implantation procedure, operate as electrical stimulators, can be temporarily moved relative to the tissue without significant restriction by the anchor during installation, can be removed without significantly damaging the tissue, and/or have other features or benefits recognized by those skilled in the art.
  • SUMMARY OF THE INVENTION
  • [0007]
    Embodiments of the invention generally relate to an anchor used to secure a position of a device or component relative to internal tissue of a patient and prevent migration of the component relative to the tissue of the patient. In one embodiment, the anchor is combined with an electrode lead that is configured for implantation in a patient. The electrode lead comprises a lead body having a proximal end and a distal end, a stimulating electrode and an anchor. The stimulating electrode is attached to the lead body at the distal end. The anchor is attached to the distal end of the lead body and comprises an anchor body and mesh attached to the anchor body.
  • [0008]
    This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. This Summary is not indented to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter. The claimed subject matter is not limited to implementations that solve any or all disadvantages noted in the Background.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0009]
    FIG. 1 is a side plan view of an exemplary electronic stimulator device, in accordance with the embodiments of the invention.
  • [0010]
    FIG. 2 is a schematic illustration of a pelvic treatment apparatus in accordance with embodiments of the invention.
  • [0011]
    FIGS. 3-5 are cross-sectional views of a distal end of an exemplary electrode lead that includes one or more tissue anchors in accordance with embodiments of the invention.
  • [0012]
    FIG. 6 is an isometric view of an anchor in accordance with embodiments of the invention.
  • [0013]
    FIG. 7 is a front cross-sectional view of an anchor in accordance with embodiments of the invention.
  • [0014]
    FIG. 8 is a cross-sectional view of a portion of an anchor in accordance with embodiments of the invention.
  • [0015]
    FIG. 9A is a side plan view of an anchor in accordance with embodiments of the invention.
  • [0016]
    FIG. 9B is a cross-sectional view of the anchor of FIG. 9A taken generally along line B-B.
  • [0017]
    FIG. 10A is a front plan view of an anchor in accordance with embodiments of the invention.
  • [0018]
    FIG. 10B is a cross-sectional view of the anchor of FIG. 10A taken generally along line B-B.
  • [0019]
    FIG. 11A is a front plan view of an anchor in accordance with embodiments of the invention.
  • [0020]
    FIG. 11B is a cross-sectional view of the anchor of FIG. 11A taken generally along line B-B.
  • [0021]
    FIG. 12 is a cross-sectional view of a portion of an anchor in accordance with embodiments of the invention.
  • [0022]
    FIG. 13 is a cross-sectional view of a portion of an anchor illustrating various embodiments of the invention.
  • [0023]
    FIGS. 14 and 15 are isometric views of anchors in accordance with embodiments of the invention.
  • [0024]
    FIGS. 16A and 16B are isometric views of anchors in accordance with embodiments of the invention.
  • [0025]
    FIG. 17 is an isometric view of an anchor in accordance with embodiments of the invention.
  • [0026]
    FIG. 18 is a front plan view of an anchor in accordance with embodiments of the invention.
  • [0027]
    FIG. 19 is a front plan view of an anchor in an expanded state.
  • [0028]
    FIGS. 20A and 20B illustrate a temporary anchor covering in accordance with embodiments of the invention.
  • [0029]
    FIGS. 21A and 21B are simplified top plan views of one embodiment of an anchor in opened and closed positions, respectively.
  • [0030]
    FIGS. 22A-22C illustrate various stages of deployment of a protruding element of an anchor in accordance with embodiments of the invention.
  • [0031]
    FIGS. 23 and 24 are simplified on-axis views of various embodiments of the anchor shown in FIGS. 22A-22C.
  • [0032]
    FIGS. 25A and 25B are simplified side views of a hinged anchor respectively in retracted and extended positions in accordance with embodiments of the invention.
  • [0033]
    FIGS. 26A and 26B are simplified side views of a hinged anchor respectively in retracted and extended positions in accordance with embodiments of the invention.
  • [0034]
    FIG. 27 is a simplified side view of an electrode lead comprising a fixation component in accordance with embodiments of the invention.
  • [0035]
    FIG. 28 is a side cross-sectional view of the electrode lead of FIG. 27 taken generally along line 28-28.
  • [0036]
    FIG. 29 is a front cross-sectional view of a distal end of an electrode lead installed within a trocar.
  • [0037]
    FIG. 30 is a simplified front cross-sectional view of a distal end of an electrode lead comprising a fixation component in accordance with embodiments of the invention.
  • [0038]
    FIG. 31 is a partial side view of an installation tool in accordance with embodiments of the invention.
  • [0039]
    FIGS. 32-34 are simplified front cross-sectional views of the distal end of an electrode lead illustrating a method of installing the electrode lead within a trocar.
  • [0040]
    FIG. 35 is a simplified front cross-sectional view of an electrode lead installed within a trocar along with a tool in accordance with embodiments of the invention.
  • [0041]
    FIG. 36 is a side cross-sectional view of FIG. 35 taken generally along line 36-36.
  • [0042]
    FIGS. 37-39 illustrate method steps of deploying the distal end of the electrode lead of FIGS. 35 and 36 within tissue of a patient, in accordance with embodiments of the invention.
  • [0043]
    FIGS. 40-42 are simplified side views of an electrode lead installation tool in accordance with embodiments of the invention.
  • [0044]
    FIG. 43 is a block diagram of a kit in accordance with embodiments of the invention.
  • DETAILED DESCRIPTION OF ILLUSTRATIVE EMBODIMENTS
  • [0045]
    Embodiments of the invention are directed to an anchor that facilitates securing devices or components, such as electrode leads, mechanical supports (e.g., meshes, slings), and other devices or components to internal tissue of a patient, and preventing migration of the devices or components from their intended position.
  • [0046]
    The tissue in which the anchor of the present invention may be use includes adipose tissue, muscle tissue or any other tissue of the patient. In one embodiment, the tissue is located in the pelvic region of the patient. In some embodiments, the tissue, in which the anchor is to be embedded, is targeted for electrical stimulation or is adjacent a desired stimulation target site. Embodiments of the invention comprise the individual embodiments described below and combinations of two or more of the embodiments described below.
  • [0047]
    Initially, exemplary devices or components with which the anchors of the present invention may be used will be discussed. FIG. 1 is a side plan view of an exemplary electronic stimulator device 100, with which embodiments of the anchors of the present invention may be used. Device 100 is configured for implantation into a pelvic region of a patient to provide muscle and/or nerve stimulation that is used to control and/or treat a pelvic condition of the patient, such as pelvic pain, urinary incontinence, fecal incontinence, erectile dysfunction or other pelvic condition that may be treated through electrical stimulation.
  • [0048]
    In one embodiment, the device 100 comprises a control unit 102 and one or more electrode leads 104, a proximal end 106 of which is coupled to the control unit 102 via a connector 108. Each electrode lead 104 comprises a lead body 110 and one or more stimulating electrodes 112 at a distal end 114 of the electrode lead 104 or lead body 110. The lead body 110 insulates electrical wires connecting the control unit 102 to the stimulating electrodes 112. The lead body 110 can be in the form of an insulating jacket typically comprising silicone, polyurethane or other flexible, biocompatible electrically insulating material. Additional electrode leads 104 or physiological sensors may be coupled to the control unit 102.
  • [0049]
    In one embodiment, the control unit 102 comprises circuitry for processing electrical signals received from the one or more stimulating electrodes 112 or physiological sensors. The control unit 102 is also configured to apply an electrical current or waveform to the tissue of the patient that is in contact with the one or more stimulating electrodes 112.
  • [0050]
    The electrode lead 104 can be anchored to pelvic tissue of the patient (e.g., internal urinary sphincter muscle) by means of a tissue anchor 120, which is formed in accordance with embodiments of the invention described below. The anchor 120 operates to secure the position of the distal end 114 of the electrode lead 104 in the desired tissue of the patient. The anchor 120 can be coupled to the lead body 110 or the stimulating electrode 112 at a location that is proximate to the distal end 114 of the electrode lead 104, for example. In one embodiment, the anchor 120 operates to provide electrical contact between the pelvic tissue of the patient and the one or more stimulation electrodes 112 of the electrode lead 104.
  • [0051]
    Another device or component with which embodiments of the anchor 120 may be used is a pelvic treatment apparatus 130, an example of which is illustrated in FIG. 2. The pelvic treatment apparatus 130 can be used to treat, for example, urinary incontinence of a patient, and generally comprises a mechanical support 132, which can be in the form of a mesh or other mechanical support that is installed to provide support to the neck of the bladder 134 or the urethra of the patient, which are generally indicated at 136. The mechanical support can be configured for implantation by any number of known surgical approaches, for example, a suprapubic approach, a transvaginal approach, a retropubic approach, and a transobturator approach.
  • [0052]
    In one embodiment, the mechanical support is anchored to pelvic tissue of the patient using one or more anchors 120 of the present invention described below. Each anchor 120 can be attached to a cable 138 or directly attached to the mechanical support 132.
  • [0053]
    In one embodiment, the pelvic treatment apparatus 130 includes one or more stimulating electrodes 140 that are attached to the mechanical support 132 or extend from the mechanical support 132 on electrode leads (not shown), such as those described above with reference to FIG. 1. A control unit 142, located inside or outside of the patient's body, drives the electrodes 140 to apply a current to a pelvic site and treat, for example, stress incontinence, urge incontinence, urge frequency, erectile dysfunction, or other pelvic dysfunctions.
  • [0054]
    FIGS. 3-5 are cross-sectional views of the distal end 114 of an electrode lead 104 that includes one or more anchors or fixation components 120 in accordance with embodiments of the invention. While FIGS. 3-5 specifically illustrate the anchor 120 in use with the electrode lead 104, it is understood that embodiments of the anchor 120 include its use with other devices and components, such as the mechanical support described above.
  • [0055]
    Each anchor 120 generally comprises one or more protruding elements 150 that are attached to an anchor body 152. It is understood that although exemplary illustrations of the anchors 120 described below comprise multiple protruding elements 150, it is understood that embodiments of the anchor 120 include anchors having a single protruding element 150 and anchors having different types of protruding elements 150 in accordance with the embodiments described herein.
  • [0056]
    Multiple embodiments of the anchor 120 that are generally independent of the type of protruding element 150 that is employed will initially be discussed with reference to FIGS. 3-5. Embodiments of the anchor body 152 include the lead body 110 (FIG. 3), the stimulating electrode 112 (FIG. 4), a mechanical support or sling 132 (FIG. 2), a cable 138 (FIG. 2), and a separate component 154 (FIG. 5) that can be attached to the lead body 110 or other component. These embodiments of the anchor body 152 are generally included in each reference to the anchor body 152.
  • [0057]
    In one embodiment, the anchor body 152 and the protruding elements 150 can be formed of a wide variety of biocompatible implant materials. Suitable materials for an implant include polymerics, and plastics such as polypropylene, polyethylene, nylon, polyester, biocompatible metals or other suitable biocompatible material. In one embodiment, the protruding elements 150 of the stimulating electrode 112 are formed of a metallic conductive material, such as that of the stimulating electrode 112.
  • [0058]
    In one embodiment, the protruding elements 150 are integral with the anchor body 152, such as the lead body 110 or the stimulating electrode 112, as respectively illustrated in FIGS. 3 and 4. Thus, the protruding elements 150 are either formed along with the formation of the anchor body 152 or are subsequently fused to the anchor body 152 through a welding or other conventional process. In one embodiment, when the protruding elements are integral with the stimulating electrode 112, the stimulating signals generated by the control unit 102 are discharged into the tissue through the electrically conductive protruding elements 150.
  • [0059]
    In one embodiment, the protruding elements 150 are non-integral to the anchor body 152. That is, the protruding elements 152 are attached to the anchor body 152 using an adhesive, a mechanical fastener or other suitable means.
  • [0060]
    As mentioned above, one embodiment of the anchor body 152 comprises a component 154 that is used to attach the anchor to the desired electrode body 110, stimulating electrode 112, mechanical support 132 or other component. In one embodiment, the component 154 comprises a hub or sleeve as shown in FIG. 5, to which one or more of the protruding elements 150 are attached. The component 154 can be attached to the lead body 110 (FIG. 5) to the stimulating electrode 112, the mechanical support 132, or other component. The protruding elements 150 can be attached to the component 154 or formed integral therewith.
  • [0061]
    In one embodiment, the component 154 comprises a cylindrical hub having a bore 156 having a diameter that is slightly larger than the external diameter the component to which it is attached and concentric thereto, an example of which is the lead body 110 shown in FIG. 5. The cylindrical hub 154 is fixedly attached to a desired portion of the lead body 110 or the stimulating electrode 112 using a biocompatible adhesive or other suitable means. In one embodiment, the bore 156 of the cylindrical hub 154 is approximately the same or smaller than the external diameter of the lead body 110 or other component to which it is attached, such that the bore 156 of the cylindrical hub 154 compresses the exterior surface 158 of the lead body 110 with sufficient force to maintain the relative positions of the cylindrical hub 154 and the lead body 110 during, and subsequent to, implantation of the electrode lead 104 in the patient.
  • [0062]
    In one embodiment, the anchor body 152 comprises a spiral tube 160, from which the one or more protruding elements 150 extend, as shown in FIG. 6. In one embodiment, the spiral tube 160 wraps around the lead body 110, the stimulating electrode 112, or other component, represented in phantom lines, and is fixed thereto using a biocompatible adhesive or through frictional resistance between the interior surface 162 of the spiral tube 160 and the exterior surface 164 of the lead body or stimulating electrode. As mentioned above, the anchor body 152 can be formed by the stimulating electrode 112. Thus, it is understood that, in a related embodiment, the stimulating electrode 112 is formed like the anchor body 152 with spiral tube 160.
  • [0063]
    The following discussion of the location and orientation of the protruding elements 150 in accordance with embodiments of the invention applies to the embodiments described above and is generally independent of the type of anchor body 152, to which the protruding elements 150 are attached. In one embodiment, at least some of the protruding elements 150 are displaced from each other along the longitudinal axis of the anchor body 152, as illustrated in FIGS. 3-5. In another embodiment, at least some of the protruding elements 150 are not displaced from each other along the longitudinal axis 170. Rather, some of the protruding elements 150 are aligned with a plane 172 that extends perpendicular to the longitudinal axis 170.
  • [0064]
    In one embodiment, the protruding elements 150 are angularly aligned such that at least some of the protruding elements 150 are positioned in the same radial plane, such as protruding elements 150A and 150B that are aligned with the radial plane 174A, which extends through the longitudinal axis 170, as shown in FIG. 7.
  • [0065]
    In one embodiment, the protruding elements 150 are angularly displaced from each other by an angle 176, as shown in FIG. 7. The angle 176 can be selected based on the type of protruding element 150 being used, the number of protruding elements 150, the type of tissue in which the protruding elements 150 are to be embedded and other factors. Exemplary angles 176 include angles that result in the equal angular displacement of the protruding elements 150 that are in the same plane 172 that is perpendicular to the longitudinal axis 170, such as 90 degrees for the exemplary embodiment illustrated in FIG. 7. In one embodiment, the angles 176 between the protruding elements are non-uniform. This may be useful when there is a side of the lead body 110 that will be in close proximity to tissue that you do not wish to contact with a protruding element 150, for example.
  • [0066]
    In another embodiment, at least some of the protruding elements 150 that are longitudinally displaced from each other are angularly staggered such that they do not lie in the same radial plane that is in line with the longitudinal axis. For instance, one or more protruding elements 150A and 150B may be positioned in the radial plane 174A while one or more other protruding elements 150C and 150D, which are longitudinally displaced from the protruding elements 150A and 150B, are positioned in the radial plane 174B that is angularly displaced from the radial plane 174A by the angle 178, as illustrated in FIG. 7.
  • [0067]
    In one embodiment, the one or more protruding elements 150 have a proximal end 180 that is attached to the anchor body 152 and a distal end 182 that is displaced from the anchor body 152 and is configured to embed in the tissue of the patient. In one embodiment, the distal end 182 of the protruding element 150 is angled toward a proximal side 184 of the anchor 120 corresponding to the proximal end 106 of the electrode lead 104, as illustrated by protruding element 150A of FIG. 8. In accordance with another embodiment, the distal end 182 of the protruding element 150 is angled toward the distal side 186 of the anchor 120 corresponding to the distal end 114 of the electrode lead 104, as illustrated by protruding element 150B in FIG. 8. In accordance with another embodiment, the anchor 120 includes a combination of protruding elements 150 having distal ends 182 that are angled toward the proximal side 184 and the distal side 186 of the anchor 120, as shown in FIG. 8.
  • [0068]
    Additional embodiments of the anchor 120 include various combinations of the above-described embodiments and one or more of the embodiments of the protruding elements 150 described below. In one embodiment, the protruding elements 150 extend radially from the anchor body 152 and operate to secure the position of the electrode lead 104 relative to the tissue in which it is embedded. The radially extending protruding element or elements 150 of the anchor 120 resist movement of the electrode lead 104 in the longitudinal direction defined by the longitudinal axis 170 of the electrode lead 104 relative to the tissue in which the electrode lead 104 is embedded. Embodiments of the protruding elements 150 can also operate to inhibit or prevent the electrode lead 104 from twisting relative to the tissue in which it is embedded.
  • [0069]
    In one embodiment, the protruding element 150 is flexible and can be compressed radially toward the anchor body 152. This compressibility of the protruding element or elements 150 allows the anchor 120 to be received within an introducer for deployment into the desired tissue of the patient. Additionally, this flexibility can provide a stress relief from forces that drive movement of the anchor 120 relative to the tissue in which the anchor 120 is embedded and can avoid or reduce the likelihood of tearing the tissue. Further, the flexibility of the protruding element 150 can drive the stimulating electrode back to its intended position relative to the tissue in response to small movements of the stimulating electrode 112.
  • [0070]
    One embodiment of the protruding element 150 comprises a tine 190, exemplary illustrations of which are shown in FIGS. 3-8. The tine 190 is preferably flexible, but can also be formed to be rigid. In one embodiment, the tine 90 is bowed slightly as shown in FIG. 8.
  • [0071]
    One embodiment of the protruding element 150 comprises a disk 192 that extends radially from the anchor body 152, as illustrated in the side plan view of FIG. 9A and the cross-sectional view of FIG. 9B taken generally along line B-B of FIG. 9A. In one embodiment, the one or more disks 192 are flexible and hold the electrode lead 104 in the tissue of the patient like plunger seal. The diameter and thickness of the disks 192 can be selected to provide the desired fixation performance.
  • [0072]
    In another embodiment of the protruding element or elements 150, the anchor 120 comprise an umbrella-shaped cup 194, as illustrated in the front plan view of FIG. 10A and the cross-sectional view of FIG. 10B, which is taken generally along line B-B of FIG. 10A. In another embodiment, the protruding element 150 comprises a cone-shaped cup 196, as illustrated in the front plan view of FIG. 11A and the side-cross sectional view of FIG. 11B, which is generally taken along line B-B of FIG. 11A. The cups 194 and 196 can be reinforced by ribs 198, which limit the amount the cups 194 or 196 flex in response to movement relative to the tissue in which they are embedded. The reinforcing ribs 198 can be formed integrally with the cups 194 or 196, extend between an exterior surface 200 and the anchor body 152 (FIG. 10B), or extend between an interior surface 202 and the anchor body 152 (FIG. 11B).
  • [0073]
    In one embodiment, the anchor 120 includes one or more protruding elements 150 in the form of barbs 204, as illustrated in the cross-sectional view of a portion of the anchor 120 provided in FIG. 12. The barbs 204 are generally smaller than the tines 190 and are preferably disposed about the surface of the anchor body 152 in greater numbers than the tines 190. The reduced gripping power that the barbs 204 have as a result of the shorter depth to which they extend into the tissue of the patient is preferably offset by greater numbers of barbs 204.
  • [0074]
    Another embodiment of the protruding element or elements 150 comprise shaped bumps 206 or ridges 208, as illustrated in the side-cross sectional view of FIG. 13. The bumps 206 generally provide a surface texture to the anchor body 152 that can increase the slip resistance between the anchor 120 and the tissue, in which the anchor 120 is embedded. The ridges 208 can be shaped similarly to the cups 194 and 196 but are generally smaller and do not extend as far radially from the anchor body 152. In one embodiment, the bumps 206 and the ridges 208 are annular and, thus, extend around the circumference of the anchor body 152.
  • [0075]
    FIG. 14 is an isometric view of an anchor 120 in accordance with another embodiment of the invention, in which the protruding elements 150 are in the form of bristles or brush-like protrusions 210. The bristles 210 can be similar to those typically found in test tube or bottle brushes. Embodiments of the protruding elements 210 include orienting the bristles such that they are substantially perpendicular to the longitudinal axis 170, or angling the protruding elements 210 toward the proximal side 184, and/or the distal side 186 of the anchor 120.
  • [0076]
    FIG. 15 is an isometric view of an anchor 120 in accordance with another embodiment of the invention, in which the protruding elements 150 are in the form of fiber loops 212 that are disposed about the exterior surface of the anchor body 152. The tissue, in which the anchor 120 is embedded, grows around and through the fibrous loops to secure the anchor 120 to the tissue. In one embodiment, the fibrous loops 212 are similar to Velcro® or DuoLock® like material, or are of a hook and loop design.
  • [0077]
    FIGS. 16A and 16B are isometric views of anchors 120, in which the protruding elements 150 comprises a spiraling thread 214. The thread 214 operates like a screw that can be screwed into the tissue of the patient by rotating the anchor 120 in the appropriate direction. In one embodiment, the thread 214 extends radially from the anchor body 152 at an angle 216 that is approximately perpendicular to the longitudinal axis 170 of the anchor body 152, as shown in FIG. 16A. In accordance with another embodiment, the thread 214 extends from the anchor body 152 at an acute angle 218 relative to the longitudinal axis 170. In one embodiment, the threads 214 are formed of a rigid plastic or other biocompatible material. In another embodiment, the threads 214 are formed of a flexible material that allows the threads 214 to flex with motion of the tissue.
  • [0078]
    FIG. 17 is an isometric view of an anchor 120 in accordance with another embodiment of the invention, in which the protruding element 150 is in the form of a mesh sleeve 220. The mesh sleeve 220 preferably extends around the circumference of the anchor body 152 and can be concentric thereto. The size of the openings or pores of the mesh sleeve 220 are preferably sufficient to allow tissue in-growth and fixation within the surrounding tissue. The mesh can be made from polypropylene, for example.
  • [0079]
    In accordance with another embodiment, a mesh material 222 is integrally formed with the anchor body 152, as illustrated in FIG. 18.
  • [0080]
    In one embodiment of the anchor 120, the anchor body 152 comprises an expandable stent like mesh 224 that is formed of a flexible material or plastic, as shown in the side plan view of FIG. 19, in which the expandable stent like mesh 224 is shown in an expanded state. During the implantation of the anchor 120 in the patient, the expandable stent like mesh 224 is placed in a compact state, similar to that illustrated in FIG. 18. Once the anchor 120 is in the desired position within the tissue of the patient, the expandable stent like mesh 224 can be expanded in accordance with conventional techniques into the tissue of the patient. The expansion of the stent 224 provides immediate resistance to movement of the anchor 120 relative to the tissue. Over time, the tissue of the patient is allowed to grow within the pores of the mesh material, which further secures the anchor 120 to the tissue of the patient.
  • [0081]
    In accordance with another embodiment of the invention, the protruding elements 150 of the anchor 120 are either partially or completely covered by a material that allows for the temporary repositioning of the anchor 120 relative to the tissue of the patient. This is particularly useful where the protruding elements are not compatible with an introducer or are relatively inflexible.
  • [0082]
    In one embodiment, the protruding elements 150 of the anchor 120 are wrapped in a sheath 226, as shown in the side cross-sectional view of FIG. 20A. The sheath 226 prevents the protruding elements 150 from gripping the tissue of the patient as the anchor 120 is moved in either the forward or rearward direction along the longitudinal axis 170 of the anchor body 152. In one embodiment, the sheath operates to compress the protruding elements 150 toward the anchor body 152, which reduces the cross-sectional area of the anchor 120 and allows for easier insertion and repositioning of the anchor 120 within the tissue of the patient.
  • [0083]
    In one embodiment, the sheath 226 can be removed after the anchor 120 or stimulating electrode 112 is placed in the desired position. In one embodiment, the sheath 226 includes a longitudinal slit that simplifies its removal. In another embodiment, a wire or other component is used to pull out the sheath 226 or generate a longitudinal slit in sheath 226 after the implantation of the electrode anchor body 152. After the sheath is removed or absorbed by the patient, the protruding elements spring open to an expanded position and embed into the tissue of the patient.
  • [0084]
    In another embodiment, the sheath 226 is formed of a material that is absorbable by the patient. Once the anchor body 120 or the stimulating electrode 112 is place in the desired position within the patient, the sheath 226 is absorbed by the body and the protruding elements 150 are allowed to become embedded within tissue of the patient.
  • [0085]
    In accordance with another embodiment, an absorbable material 228 is positioned at least about the protruding elements 150 to prevent the protruding elements 150 from snagging the tissue of the patient. The material 228 allows the anchor 120 to be moved in either direction along the longitudinal axis 170 within the tissue of the patient. After the anchor 120 is placed in the desired position within the tissue of the patient, the absorbable material gets absorbed by the patient over time and the protruding elements become embedded in the tissue of the patient.
  • [0086]
    The anchor 120 illustrated in the top plan views of FIGS. 21A and 21B comprises a pair of protruding elements 150 that can be placed in an expanded position 230, which is illustrated in FIG. 21A, and a closed or clamping position 232, which is illustrated in FIG. 21B. Initially, the anchor 120 is driven into the tissue 234 of the patient while in the expanded position 230. Once inserted into the tissue as desired, the protruding elements 150 of the anchor 120 are brought together to the clamping position 232 and the tissue is pinched between the protruding elements 150. When in the clamping position, the protruding elements 150 grip the tissue 234 and secure the anchor 120 to the tissue 234. In one embodiment, one or more stimulating electrodes 112 are located at the distal end 182 of at least one of the protruding elements 150 and are configured to apply electrical stimulation to the tissue 234 that is generated by the control unit 102 described above.
  • [0087]
    FIGS. 22A-C illustrate an anchor 120 in accordance with another embodiment of the invention, in which the protruding element or elements 150 comprise a fine wire 240 that extends out of a lumen 242 that is formed in the anchor body 152. In one embodiment, the wire 240 is initially in a retracted position, shown in FIG. 22A, in which the wire 240 is either slightly extended out of the lumen 242 (as shown) or fully retracted within the lumen 242. This arrangement allows the anchor 120 to be fed into the tissue of the patient. Once the anchor 120 is in the desired position within the tissue of the patient, the wire 240 can be extended out of the lumen 242 and into the tissue, as illustrated in FIG. 22B. In one embodiment, the wire 240 coils as it is fed into the tissue of the patient, as illustrated in FIG. 22C. In one embodiment, the wire 240 is formed of a memory shaped material, such as nickel titanium (i.e., NITINOL), that forces the wire 240 to follow a coil trajectory through the surrounding tissue of the patient as it is extended from the lumen 242. Embodiments of the anchor 120 include one or more wires 240. The wires 240 can be angularly displaced about the surface of the anchor body 120, as illustrated in the on-axis view of FIG. 23. In one embodiment, the wires 240 are configured to coil around the anchor body 152, as illustrated in the on-axis view of FIG. 24.
  • [0088]
    Another embodiment of the anchor 120 of the present invention comprises one or more protruding elements 150 that are configured to have a retracted position, in which the distal end 182 of the protruding element 150 is located in close proximity to the anchor body 152, and an extended position, in which the distal end 182 is displaced radially from the anchor body 152. FIGS. 25A and 25B are side plan views of an embodiment of a protruding element 150 respectively in a retracted position 244 and an extended position 246. When in the retracted position 244, the distal end 182 of the protruding element 150 lies in close proximity to the exterior surface 248 of the anchor body 152. In one embodiment, the protruding element 150 is flexible and is configured to bend at a portion 250 that is adjacent to the proximal end 180. A protruding element 150 can move to this retracted position 244 automatically in response to the feeding of the anchor 120 through the tissue of the patient or by placing the anchor 120 in a tube of an introducer, for example.
  • [0089]
    Once the anchor 120 is positioned as desired in the tissue of the patient, the anchor body 152 can be pulled toward the proximal side 184. During this movement of the anchor body 120, the distal end 182 of the protruding element 150 snags a portion of the tissue of the patient and the protruding element 150 is driven to the extended position 246 shown in FIG. 25B. With only a slight movement of the anchor body 152 toward the proximal side 184, the protruding element 150 can reach the fully extended position 246. In one embodiment, a stop member 252 is positioned to limit the distance that the distal end 182 of the protruding element 150 can move toward the distal side 186. Thus, the stop member 252 defines the fully extended position 246 for the protruding element 150.
  • [0090]
    FIGS. 26A and 26B respectively illustrate another embodiment of a protruding element 150 having a retracted position 244 and an extended position 246. In accordance with one embodiment, the protruding element 150 is coupled to the anchor body 152 by a hinge 254. The protruding element 150 is allowed to pivot about the hinge 254 between the retracted position 244 shown in FIG. 26A and the extended position 246 shown in FIG. 26B. As with the embodiment of the protruding element 150 described above with regard to FIGS. 25A and 25B, the protruding element 150 shown in FIGS. 26A and 26B moves from the retracted position 244 to the extended position 246 in response to movement of the anchor body 152 toward the proximal side 184 or during the slight withdrawal of the anchor 120 from the tissue of the patient.
  • [0091]
    FIG. 27 illustrates a simplified side view of a distal end 114 of an electrode lead 104 having a lead body 110 that includes an anchor 257, in accordance with embodiments of the invention, that is implanted in tissue 258 of the patient. FIG. 28 provides a cross-sectional view of the anchor 257 taken generally along line 28-28 of FIG. 27 and illustrates the implantation of the distal end 114 of the electrode adjacent a structure 259 of the patient.
  • [0092]
    As discussed above, one embodiment of the electrode lead 104 comprises one or more electrodes 112, each located at a distal end 114 of the lead body 110. The electrodes 112 may be separated by an insulating element 267, which may comprise the lead body 110.
  • [0093]
    One embodiment of the anchor 257 comprises an anchor body 152 in accordance with the embodiments described above, such as the lead body 110 (FIG. 27), and a section of mesh 260 attached to the anchor body 152. In one embodiment, the anchor 257 is located at the distal end 114 of the electrode lead 104. The bio-compatible mesh 260 is preferably an open matrix mesh, such as a mesh constructed of polypropylene monofilament. In one embodiment, the mesh 260 comprises one or more mesh sections or wings, such as wings 261 and 262.
  • [0094]
    In one embodiment, the mesh 260 has a compact state and an expanded state. In general, at least a portion of the mesh 260 is displaced a greater distance from the anchor body 152 when in the expanded state than when in the compact state. The anchor 257 is generally in a form suitable for implantation in the tissue 258 when the mesh 260 is in the compact state and performs its anchoring function in the tissue 258 when the mesh 260 is in the expanded state, such as described above with regard to FIG. 19.
  • [0095]
    In one embodiment, the mesh 260 has a shape memory that drives the mesh to a preset expanded, quiescent shape, in which at least a portion of the mesh 260 extends away from the anchor body 152 and into the surrounding tissue 258. As used herein, the “quiescent shape” of the mesh 260 is one in which the mesh will naturally return to after being deformed, such as when compressed into a compact state.
  • [0096]
    In one embodiment, the expanded state of the mesh wings 261 and 262 is one in which the wings 261 and 262 are displaced from each other, such as illustrated FIG. 28. Thus, one embodiment of the mesh 260 has a shape memory that encourages separation of the one or more wings, such as wings 261 and 262, within the tissue 258.
  • [0097]
    In one embodiment, the anchor 257 is configured to deliver electrical signals from the control unit to the tissue 258. In one embodiment, the mesh 260 comprises the one or more electrodes 112 that are used to deliver electrical signals to the tissue 258. In one embodiment, one or more conductive fibers 264 (FIG. 27) are attached to the mesh 260 and conduct electrical signals from one or more of the electrodes 112 of the lead body (FIG. 27), or the control unit 102, into the tissue 258. In one embodiment, the conductive fivers 264 are electrically insulated from the tissue 258 and conduct the electrical signals to one or more electrically conductive nodes or electrodes 266 that are attached to the mesh 260 and deliver the electrical signals to the tissue 258.
  • [0098]
    A portion of the mesh 260 is attached to the distal end 114 of the electrode lead 104 at a location 268. Exemplary means for attaching the mesh 260 to the electrode lead 104 include sutures, glue, anchors, or other suitable bio-compatible methods. In one embodiment, the attachment location 268 comprises a central portion of the mesh 260. As a result, one embodiment of the anchor 257 comprises at least two wings of mesh 261 and 262 that extend from the distal end of the electrode lead 104 at the connection location 268.
  • [0099]
    FIG. 29 is a simplified cross-sectional view of the distal end 114 of the electrode lead 104 having the anchor 257 installed in a delivery trocar 270 that is used to implant the electrode lead 104 in the desired tissue 258 of the patient. In one embodiment, the mesh 260 of the anchor 257 is placed in the compact state (e.g., rolled up) and installed in the trocar 270. When the anchor 257 is deployed from the trocar 270 into the tissue 258, the mesh 260 expands toward the expanded state or its expanded quiescent shape. Tissue ingrowth secures the mesh 260 to the tissue 258 to anchor the location of the distal end 114 of the electrode lead 104.
  • [0100]
    When the mesh 260 comprises the wings 261 and 262, the wings 261 and 262 compressed into the compact state, as shown in FIG. 29. In one embodiment, the mesh wings 261 and 262 extend from the connection point 268 away from the distal end 114 of the electrode lead 104. Upon deployment of the distal end 114 of the electrode lead 104 in the desired tissue 258 of the patient, the mesh sections 261 and 262 move toward the preset expanded quiescent shape and into the tissue 258, as shown in FIG. 28. Ingrowth of the tissue 258 into the mesh 260 operates to anchor the mesh 260 to the tissue 258, thereby anchoring the distal end 114 of the electrode lead 104 in the desired position.
  • [0101]
    In one embodiment, the mesh 260 is deployed in the tissue 258 such that it has a desired orientation relative to the structure 259 of the patient. As a result, the expansion of the mesh 260 can be directed to a side of the electrode lead 104 such that it expands away from the structure 259 or toward the structure 259. For instance, when the structure 259 is in the form of the urethra of the patient, the distal end 114 of the electrode lead 104 can be oriented relative to the urethra 259 such that the mesh 260 is located on a side of the electrode lead 104 that is away from the urethra 259. This prevents fibrosis around the mesh 260 from interfering with the communication of electrical stimulation signals from the electrode lead 104 to the structure 259.
  • [0102]
    In one embodiment, the anchor 257 is initially provided in a sterilized and sealed package, in which the mesh 260, such as mesh sections 261 and 262, have a quiescent shape in which they lie substantially flat, as illustrated in the simplified cross-sectional view of FIG. 30. FIG. 31 is a simplified side view of an installation tool 276 in accordance with embodiments of the invention that is used to prepare the anchor 257 for installation within a trocar 270. The tool 276 comprises a forked end 278 that includes prongs 280 and 282 that extend substantially parallel to the longitudinal axis 284 of the tool 276. A gap 286 between the prongs 280 and 282 is configured to receive a distal end 288 of the mesh 260, as illustrated in the simplified cross-sectional view of FIG. 32.
  • [0103]
    The anchor 257 is prepared for installation within a trocar 270 by placing the end 288 of the mesh 260 through the gap 286 and rotating the tool 276, such as in the direction indicated by arrow 290, to roll up the mesh 260, as illustrated in simplified front cross-sectional views of FIGS. 32 and 33. Once the mesh 260 has been rolled up into a compact state, the distal end 114 of the electrode lead 104 and the anchor 257 can be installed in a trocar 270, as illustrated in the simplified cross-sectional view of FIG. 34. The end 278 of the tool 276 is disengaged from the mesh 260 either prior to or after the insertion of the distal end 114 within the trocar 270. When the distal end 114 of the electrode lead 104 is deployed into the desired tissue 258 of the patient using the trocar 270, the mesh 260 expands toward its expanded quiescent shape within the tissue 258, as discussed above.
  • [0104]
    FIGS. 35 and 36 respectively are front and side cross-sectional views of a distal end 114 of the electrode lead 104 comprising the anchor 257 installed within a trocar 270, in accordance with embodiments of the invention. A tool 292 is installed in the trocar 270 to aid in the deployment of the mesh wings 261 and 262.
  • [0105]
    In one embodiment, the tool 292 operates to separate the mesh wings 261 and 262 and prevent their entanglement within the trocar 270.
  • [0106]
    In one embodiment, the tool 292 is configured to cause or assist in the expansion of the mesh wings 261 and 262 into the tissue 258 after deployment of the distal end 114 into the tissue 258. In one embodiment, once the distal end 114 of the electrode lead 104 held in the trocar 270 is located at the desired position within the tissue 258 of the patient, the trocar 270 is partially retracted, as illustrated in the side cross-sectional view of FIG. 37. In one embodiment, the cross-sectional width of the end 284 of the tool 292 is expanded, which drives the mesh wings 261 and 262 away from each other within the tissue 258, as illustrated in FIG. 38. The distal end 294 of the tool 292 can then be withdrawn into the trocar 270 and removed from the patient through the trocar 270 to complete the implantation of the distal end 114 of the electrode lead 104 within the tissue 258 of the patient, as illustrated in the cross-sectional view of FIG. 39. In one embodiment, the cross-sectional width of the end 294 of the tool 292 is reduced prior to its withdrawal from the patient.
  • [0107]
    In one embodiment, the tool 292 comprises a scissor-like mechanism that expands the effective width of the distal end 294.
  • [0108]
    FIGS. 40-42 are simplified side views of a tool 292 in accordance with embodiments of the invention. In one embodiment, the tool 292 comprises first and second elongated components 296 and 298 that are respectively coupled to a third component 300 through hinges 302 and 304. The initial width 306 of the tool 292 allows the tool 292 to be received within the trocar 270, as shown in FIGS. 35 and 36. Following the retraction of the trocar 270 (FIG. 37), component 296 is moved relative to component 298, such as, for example, in the direction indicated by arrow 308. The displacement of the hinge 304 from the hinge 302 in the widthwise direction causes the component 300 to pivot about the hinge 302 relative to the component 298 in the direction indicated by arrow 310 to an expanded position, as shown in FIG. 41. The width 312 of the distal end 294 of the tool 292 in the expanded position is significantly greater than the width 306. This expansion of the width of the distal end 294 drives the expansion of the mesh wings 261 and 262, as illustrated in FIG. 38.
  • [0109]
    After the mesh wings 261 and 262 have been expanded through the expansion of the width of the distal end 294 of the tool 292, the component 296 can be further moved relative to the component 298 in a direction indicated by arrow 308 to place the distal end 294 in a compacted state (FIG. 42), in which the tool 292 may either be received again within the trocar 270, or otherwise removed from the patient, while leaving the distal end 114 of the electrode lead 104 in the desired location within the tissue 258 of the patient.
  • [0110]
    Additional embodiments of the invention are directed to kits that include one or more of the embodiments described above. FIG. 43 illustrates a kit 320 in accordance with embodiments of the invention. In one embodiment, the kit includes a package 322 containing components including one or more electrode leads 104 in accordance with one or more of the embodiments described above. In one embodiment, the kit 320 includes the control unit 102. In one embodiment, the kit includes instructions 326 for installing the one or more electrode leads 104 in the patient. In one embodiment, the instructions 324 include instructions for installing the control unit 102.
  • [0111]
    In one embodiment, the one or more electrode leads 104 in the kit 320 include an anchor 326 in accordance with one or more of the embodiments described above, such as anchor 120 or 257. In accordance with one embodiment, the distal end 114 of the one or more electrode leads are provided pre-installed in a trocar 270. In accordance with one embodiment, one or more tools, such as installation tool 278 or deployment tool 292, are provided in the kit 320. Embodiments of the instructions 324 include instructions for implanting the distal end 114 of the electrode lead 104 within tissue 258 of the patient using the trocar 270, tool 278 and/or tool 292. Such instructions include instructions describing one or more of the method steps discussed above with reference to FIGS. 32-42.
  • [0112]
    Although the present invention has been described with reference to preferred embodiments, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention.

Claims (20)

  1. 1. An electrode lead configured for implantation in a patient comprising
    a lead body having proximal and distal ends;
    an electrode formed of an electrically conductive material and attached to the distal end of the lead body; and
    an anchor attached to the distal end of the lead body, the anchor comprising an anchor body and mesh attached to the anchor body.
  2. 2. The electrode lead of claim 1, wherein the mesh comprises compact and an expanded states, wherein at least a portion of the mesh is displaced a greater distance from the anchor body when in the expanded state than when in the compact state.
  3. 3. The electrode lead of claim 2, wherein:
    the mesh comprises first and second wings of mesh; and
    the mesh wings are each biased to move from the compact state to the expanded state.
  4. 4. The electrode lead of claim 2, wherein the anchor comprises an expandable stent like mesh.
  5. 5. The electrode lead of claim 1, wherein the mesh comprises first and second wings.
  6. 6. The electrode lead of claim 5, wherein the first and second wings each have a quiescent shape in which they are extended away from the anchor body.
  7. 7. The electrode lead of claim 1, further comprising one or more conductive fibers attached to the mesh.
  8. 8. The electrode lead of claim 7, wherein the electrode is attached to the mesh and the one or more conductive fibers.
  9. 9. The electrode lead of claim 8, wherein:
    the mesh comprises first and second wings; and
    the first and second wings each have a quiescent shape in which they are extended away from the anchor body.
  10. 10. The electrode lead of claim 1, wherein the anchor body is selected from the group consisting of the lead body, the electrode, a component coupled to the lead body, and a component coupled to the stimulating electrode.
  11. 11. An assembly comprising:
    an electrode lead comprising:
    a lead body having proximal and distal ends;
    an electrode formed of an electrically conductive material and attached to the distal end of the lead body; and
    an anchor attached to the distal end of the lead body, the anchor comprising an anchor body and mesh attached to the anchor body; and
    a trocar;
    wherein the distal end of the lead body, the electrode and the anchor are installed within the trocar.
  12. 12. The assembly of claim 11, wherein the mesh is rolled upon itself.
  13. 13. The assembly of claim 11, wherein the mesh comprises first and second wings.
  14. 14. The assembly of claim 13, wherein the first and second wings each have a quiescent shape in which they are extended away from the anchor body.
  15. 15. The assembly of claim 11, wherein:
    the electrode is attached to the mesh; and
    the electrode lead further comprises one or more conductive fibers attached to the mesh and configured to deliver electrical signals to the electrode.
  16. 16. The assembly of claim 11, further comprising a tool having an expandable distal end positioned within the trocar adjacent the mesh.
  17. 17. A kit comprising:
    a package; and
    an electrode lead contained in the package, the electrode lead comprising:
    a lead body having proximal and distal ends;
    an electrode formed of an electrically conductive material and attached to the distal end of the lead body; and
    an anchor attached to the distal end of the lead body, the anchor comprising an anchor body and mesh attached to the anchor body.
  18. 18. The kit of claim 17, further comprising:
    a trocar contained in the package, wherein the distal end of the lead body is within the trocar; and
    a tool having an expandable distal end positioned within the trocar adjacent the mesh.
  19. 19. The kit of claim 18, further comprising instructions for implanting the electrode lead in tissue of a patient using the trocar and the tool.
  20. 20. The kit of claim 17, further comprising an implantable control unit configured to deliver electrical signals to the electrode.
US12558143 2006-07-10 2009-09-11 Tissue anchor Abandoned US20100049289A1 (en)

Priority Applications (5)

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US94890807 true 2007-07-10 2007-07-10
US12170582 US20090012592A1 (en) 2006-07-10 2008-07-10 Tissue anchor
US9638708 true 2008-09-12 2008-09-12
US16076509 true 2009-03-17 2009-03-17
US12558143 US20100049289A1 (en) 2007-07-10 2009-09-11 Tissue anchor

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12558143 US20100049289A1 (en) 2007-07-10 2009-09-11 Tissue anchor
EP20150176464 EP2974769B1 (en) 2009-03-17 2010-03-16 Implantable device and tissue anchor
US13256825 US20120095478A1 (en) 2009-03-17 2010-03-16 Implantable device and tissue anchor
PCT/US2010/027419 WO2010107751A8 (en) 2009-03-17 2010-03-16 Implantable device and tissue anchor
EP20100710501 EP2408515B1 (en) 2009-03-17 2010-03-16 Implantable device and tissue anchor
EP20100176162 EP2295109A3 (en) 2009-09-11 2010-09-10 Tissue anchor
US13167541 US9427573B2 (en) 2007-07-10 2011-06-23 Deployable electrode lead anchor
US13431594 US8774942B2 (en) 2007-07-10 2012-03-27 Tissue anchor
US15219521 US9889292B2 (en) 2007-07-10 2016-07-26 Deployable electrode lead anchor

Related Parent Applications (1)

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US12170582 Continuation-In-Part US20090012592A1 (en) 2006-07-10 2008-07-10 Tissue anchor

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US13167541 Continuation-In-Part US9427573B2 (en) 2006-07-10 2011-06-23 Deployable electrode lead anchor
US13431594 Continuation US8774942B2 (en) 2006-07-10 2012-03-27 Tissue anchor

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US20100049289A1 true true US20100049289A1 (en) 2010-02-25

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US12558143 Abandoned US20100049289A1 (en) 2006-07-10 2009-09-11 Tissue anchor
US13256825 Abandoned US20120095478A1 (en) 2007-07-10 2010-03-16 Implantable device and tissue anchor
US13431594 Active US8774942B2 (en) 2006-07-10 2012-03-27 Tissue anchor

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US13256825 Abandoned US20120095478A1 (en) 2007-07-10 2010-03-16 Implantable device and tissue anchor
US13431594 Active US8774942B2 (en) 2006-07-10 2012-03-27 Tissue anchor

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070219606A1 (en) * 2006-03-14 2007-09-20 Boston Scientific Scimed, Inc. Heatable sling support for an anatomical location
US20070265675A1 (en) * 2006-05-09 2007-11-15 Ams Research Corporation Testing Efficacy of Therapeutic Mechanical or Electrical Nerve or Muscle Stimulation
US20090036946A1 (en) * 2001-11-29 2009-02-05 American Medical Systems, Inc. Pelvic disorder treatments
US20090043356A1 (en) * 2006-03-03 2009-02-12 Ams Research Corporation Electrode Sling for Treating Stress and Urge Incontinence
US8160710B2 (en) 2006-07-10 2012-04-17 Ams Research Corporation Systems and methods for implanting tissue stimulation electrodes in the pelvic region
US8311647B2 (en) 2007-01-30 2012-11-13 Cardiac Pacemakers, Inc. Direct delivery system for transvascular lead
US8380312B2 (en) 2009-12-31 2013-02-19 Ams Research Corporation Multi-zone stimulation implant system and method
US8412350B2 (en) 2007-01-30 2013-04-02 Cardiac Pacemakers, Inc. Neurostimulating lead having a stent-like anchor
WO2013036399A3 (en) * 2011-09-08 2013-06-27 Ams Research Corporation Implantable electrode assembly
US8774942B2 (en) 2007-07-10 2014-07-08 Ams Research Corporation Tissue anchor
WO2014146000A3 (en) * 2013-03-15 2014-11-06 Micro Interventional Devices, Inc. Tissue closure device and method
US9050065B2 (en) 2010-01-20 2015-06-09 Micro Interventional Devices, Inc. Tissue repair implant and delivery device and method
US9220887B2 (en) 2011-06-09 2015-12-29 Astora Women's Health LLC Electrode lead including a deployable tissue anchor
US9427573B2 (en) 2007-07-10 2016-08-30 Astora Women's Health, Llc Deployable electrode lead anchor
US9539433B1 (en) 2009-03-18 2017-01-10 Astora Women's Health, Llc Electrode implantation in a pelvic floor muscular structure

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2295109A3 (en) * 2009-09-11 2011-05-25 AMS Research Corporation Tissue anchor
CN107080561A (en) 2011-12-09 2017-08-22 麦特文申公司 Device, system, and method for neuroregulation
US9889310B2 (en) 2014-07-23 2018-02-13 Medtronic, Inc. Suture loop with cover and strategic placement of suture points
JP2017523870A (en) 2014-08-15 2017-08-24 アクソニクス モジュレーション テクノロジーズ インコーポレイテッド Implantable lead affixed construction for neural stimulation to relieve bladder dysfunction and other symptoms
US9517338B1 (en) 2016-01-19 2016-12-13 Axonics Modulation Technologies, Inc. Multichannel clip device and methods of use

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3628538A (en) * 1968-09-18 1971-12-21 Nat Res Dev Apparatus for stimulating muscles controlled by the same muscles
US3640284A (en) * 1970-01-05 1972-02-08 Philip A De Langis Apparatus for electrotherapy of the pubococcygeus
US3646940A (en) * 1969-07-15 1972-03-07 Univ Minnesota Implantable electronic stimulator electrode and method
US3650276A (en) * 1969-03-26 1972-03-21 Inst Demedicina Si Farmacie Method and apparatus, including a flexible electrode, for the electric neurostimulation of the neurogenic bladder
US3662758A (en) * 1969-06-30 1972-05-16 Mentor Corp Stimulator apparatus for muscular organs with external transmitter and implantable receiver
US3667477A (en) * 1966-11-25 1972-06-06 Canadian Patents Dev Implantable vesical stimulator
US3866613A (en) * 1972-07-13 1975-02-18 Devices Implants Limited Pessary ring electrode system
US3870051A (en) * 1972-04-27 1975-03-11 Nat Res Dev Urinary control
US3926178A (en) * 1975-01-17 1975-12-16 Alvin N Feldzamen Apparatus for aiding the voluntary exercising of sphincter muscles
US3941136A (en) * 1973-11-21 1976-03-02 Neuronyx Corporation Method for artificially inducing urination, defecation, or sexual excitation
US3983881A (en) * 1975-05-21 1976-10-05 Telectronics Pty. Limited Muscle stimulator
US3983865A (en) * 1975-02-05 1976-10-05 Shepard Richard S Method and apparatus for myofunctional biofeedback
US4010758A (en) * 1975-09-03 1977-03-08 Medtronic, Inc. Bipolar body tissue electrode
US4023574A (en) * 1974-10-18 1977-05-17 Hans Nemec Electrostimulation method and apparatus
US4030509A (en) * 1975-09-30 1977-06-21 Mieczyslaw Mirowski Implantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilization
US4044774A (en) * 1976-02-23 1977-08-30 Medtronic, Inc. Percutaneously inserted spinal cord stimulation lead
US4106511A (en) * 1976-04-21 1978-08-15 Svenska Utvecklingsaktiebolaget Electrical stimulator in remedy of incontinence
US4136684A (en) * 1977-02-07 1979-01-30 Scattergood Mark G Linear electromyographic biofeedback system
US4139006A (en) * 1977-03-18 1979-02-13 Corey Arthur E Female incontinence device
US4153059A (en) * 1977-10-25 1979-05-08 Minnesota Mining And Manufacturing Company Urinary incontinence stimulator system
US4157087A (en) * 1978-03-06 1979-06-05 Med General, Inc. Peripheral nerve stimulator
US4165750A (en) * 1978-03-18 1979-08-28 Aleev Leonid S Bioelectrically controlled electric stimulator of human muscles
US4177819A (en) * 1978-03-30 1979-12-11 Kofsky Harvey I Muscle stimulating apparatus
US4222377A (en) * 1977-06-27 1980-09-16 American Medical Systems, Inc. Pressure regulated artificial sphincter systems
US4290420A (en) * 1980-06-09 1981-09-22 Alberto Manetta Stress incontinence diagnostic and treatment device
US4387719A (en) * 1980-10-23 1983-06-14 Gorenje Tovarna Gospodinjske Opreme N.Sol.O. Velenje Control circuit of a therapeutic stimulator for the urinary incontinence
US4402328A (en) * 1981-04-28 1983-09-06 Telectronics Pty. Limited Crista terminalis atrial electrode lead
US4406288A (en) * 1981-04-06 1983-09-27 Hugh P. Cash Bladder control device and method
US4414986A (en) * 1982-01-29 1983-11-15 Medtronic, Inc. Biomedical stimulation lead
US4431001A (en) * 1980-09-17 1984-02-14 Crafon Medical Ab Stimulator system
US4457299A (en) * 1981-02-06 1984-07-03 Cornwell George H I Incontinence control devices
US4492233A (en) * 1982-09-14 1985-01-08 Wright State University Method and apparatus for providing feedback-controlled muscle stimulation
US4515167A (en) * 1983-02-28 1985-05-07 Hochman Joel S Device for the development, training and rehabilitation of the pubococcygeal and related perineal musculature of the female
US4542753A (en) * 1982-12-22 1985-09-24 Biosonics, Inc. Apparatus and method for stimulating penile erectile tissue
US4568339A (en) * 1982-11-05 1986-02-04 Craig Medical Products, Limited Female incontinence device
US4569351A (en) * 1984-12-20 1986-02-11 University Of Health Sciences/The Chicago Medical School Apparatus and method for stimulating micturition and certain muscles in paraplegic mammals
US4571749A (en) * 1982-09-21 1986-02-25 The Johns Hopkins University Manually actuated hydraulic sphincter
US4580578A (en) * 1983-05-06 1986-04-08 Richard Wolf Gmbh Device for the treatment of female urinary incontinence
US4585005A (en) * 1984-04-06 1986-04-29 Regents Of University Of California Method and pacemaker for stimulating penile erection
US4602624A (en) * 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4607639A (en) * 1984-05-18 1986-08-26 Regents Of The University Of California Method and system for controlling bladder evacuation
US4628942A (en) * 1984-10-11 1986-12-16 Case Western Reserve University Asymmetric shielded two electrode cuff
US4688575A (en) * 1982-03-12 1987-08-25 Duvall Wilbur E Muscle contraction stimulation
US4703755A (en) * 1984-05-18 1987-11-03 The Regents Of The University Of California Control system for the stimulation of two bodily functions
US4731083A (en) * 1982-09-21 1988-03-15 The Johns Hopkins University Manually actuated hydraulic sphincter
US4739764A (en) * 1984-05-18 1988-04-26 The Regents Of The University Of California Method for stimulating pelvic floor muscles for regulating pelvic viscera
US4750494A (en) * 1981-05-12 1988-06-14 Medtronic, Inc. Automatic implantable fibrillation preventer
US4771779A (en) * 1984-05-18 1988-09-20 The Regents Of The University Of California System for controlling bladder evacuation
US4785828A (en) * 1986-10-06 1988-11-22 Empi, Inc. Vaginal stimulator for controlling urinary incontinence in women
US4848005A (en) * 1987-02-03 1989-07-18 D.E.A. Digital Electronic Automation S.P.A. Rearrangeable supporting and positioning fixture, particularly for parts measurable on a gauging machine
US4881526A (en) * 1988-05-27 1989-11-21 Empi, Inc. Intravaginal electrode and stimulation system for controlling female urinary incontinence
US4913164A (en) * 1988-09-27 1990-04-03 Intermedics, Inc. Extensible passive fixation mechanism for lead assembly of an implantable cardiac stimulator
US4941874A (en) * 1987-08-11 1990-07-17 Hoechst Aktiengesellschaft Device for the administration of implants
US5013292A (en) * 1989-02-24 1991-05-07 R. Laborie Medical Corporation Surgical correction of female urinary stress incontinence and kit therefor
US5019032A (en) * 1990-04-03 1991-05-28 Robertson Jack R Refined suspension procedure with implement for treating female stress incontinence
US5082006A (en) * 1987-09-15 1992-01-21 Linda Jonasson Device for preventing involuntary micturition
US5094242A (en) * 1988-11-07 1992-03-10 Regents Of The University Of California Implantable nerve stimulation device
US5103835A (en) * 1990-05-02 1992-04-14 Nihon Kohden Corporation Impedance monitoring device for preventing urinary incontinence
US5112344A (en) * 1988-10-04 1992-05-12 Petros Peter E Surgical instrument and method of utilization of such
US5193539A (en) * 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5193540A (en) * 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5199430A (en) * 1991-03-11 1993-04-06 Case Western Reserve University Micturitional assist device
US5285781A (en) * 1990-05-26 1994-02-15 Stiwell S. A. Electrical neuromuscular stimulation device
US5291902A (en) * 1993-01-11 1994-03-08 Brent Carman Incontinence treatment
US5312439A (en) * 1991-12-12 1994-05-17 Loeb Gerald E Implantable device having an electrolytic storage electrode
US5324324A (en) * 1992-10-13 1994-06-28 Siemens Pacesetter, Inc. Coated implantable stimulation electrode and lead
US5330507A (en) * 1992-04-24 1994-07-19 Medtronic, Inc. Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias
US5358514A (en) * 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5417226A (en) * 1994-06-09 1995-05-23 Juma; Saad Female anti-incontinence device
US5423329A (en) * 1994-04-15 1995-06-13 Rehab Centers Of America, Inc. Method of treatment for urinary incontinence
US5452719A (en) * 1991-07-23 1995-09-26 Eisman; Eugene Multiple electrode myographic probe and method
US5931864A (en) * 1998-02-20 1999-08-03 Cardiac Pacemakers, Inc. Coronary venous lead having fixation mechanism
US5954761A (en) * 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US6141594A (en) * 1998-07-22 2000-10-31 Cardiac Pacemakers, Inc. Single pass lead and system with active and passive fixation elements
US6161029A (en) * 1999-03-08 2000-12-12 Medtronic, Inc. Apparatus and method for fixing electrodes in a blood vessel
US6243607B1 (en) * 1996-09-05 2001-06-05 University Technologies International Inc. Gastro-intestinal electrical pacemaker
US6397109B1 (en) * 1998-12-23 2002-05-28 Avio Maria Perna Single pass multiple chamber implantable electro-catheter for multi-site electrical therapy of up to four cardiac chambers, indicated in the treatment of such pathologies as atrial fibrillation and congestive/dilate cardio myopathy
US20030019961A1 (en) * 2001-07-20 2003-01-30 Horst Hohnen Method and device for the in situ disposal of incontinence articles
US20030023296A1 (en) * 2001-07-25 2003-01-30 Osypka Thomas P. Implantable coronary sinus lead with mapping capabilities
US20030060868A1 (en) * 1997-12-24 2003-03-27 Cardiac Pacemakers, Inc. High impedance electrode tip
US6582441B1 (en) * 2000-02-24 2003-06-24 Advanced Bionics Corporation Surgical insertion tool
US6612977B2 (en) * 2001-01-23 2003-09-02 American Medical Systems Inc. Sling delivery system and method of use
US6911003B2 (en) * 2002-03-07 2005-06-28 Ams Research Corporation Transobturator surgical articles and methods
US20050149156A1 (en) * 2003-12-24 2005-07-07 Imad Libbus Lead for stimulating the baroreceptors in the pulmonary artery
US20050228346A1 (en) * 2004-04-09 2005-10-13 Cook Vascular Incorporated Modular hemostatic valve
US20060241733A1 (en) * 2005-04-25 2006-10-26 Cardiac Pacemakers, Inc. Atrial pacing lead
US20070043416A1 (en) * 2005-08-19 2007-02-22 Cardiac Pacemakers, Inc. Implantable electrode array
US20070179559A1 (en) * 2006-01-31 2007-08-02 Medtronic, Inc. Electrical stimulation to alleviate chronic pelvic pain
US20070255333A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Neuromodulation therapy for perineal or dorsal branch of pudendal nerve
US20070253997A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Drug delivery to alleviate chronic pelvic pain
US20070255341A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Electrical stimulation of ilioinguinal nerve to alleviate chronic pelvic pain
US20070253998A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Drug delivery to iliohypogastric nerve to alleviate chronic pelvic pain
US7319905B1 (en) * 2004-11-30 2008-01-15 Pacesetter, Inc. Passive fixation mechanism for epicardial sensing and stimulation lead placed through pericardial access
US7613516B2 (en) * 2001-11-29 2009-11-03 Ams Research Corporation Pelvic disorder treatment device
US7771345B1 (en) * 2002-12-03 2010-08-10 O'donnell Pat D Surgical instrument for treating female urinary stress incontinence

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3999555A (en) 1975-10-28 1976-12-28 Medtronic, Inc. Atrial pinch on lead and insertion tool
US4419819A (en) * 1982-01-29 1983-12-13 Medtronic, Inc. Method of making biomedical lead with lobed lead anchor
US4669488A (en) * 1983-03-28 1987-06-02 Cordis Corporation Retention skirt for pacing electrode assembly
US4519404A (en) * 1983-09-28 1985-05-28 Fleischhacker John J Endocardial electrode lead with conical fixation mechanism
US4550737A (en) 1983-10-12 1985-11-05 Peter Osypka Intravenously implantable electrode lead for use with cardiac pacemakers
US4590949A (en) 1984-11-01 1986-05-27 Cordis Corporation Neural stimulating lead with stabilizing mechanism and method for using same
DE3673644D1 (en) 1986-05-12 1990-09-27 Univ California An electronic system for nerve stimulation of pelvic organs.
US5520606A (en) 1990-10-18 1996-05-28 Schoolman; Arnold Mechanical urinary sphincter device
US6131575A (en) 1991-01-10 2000-10-17 The Procter & Gamble Company Urinary incontinence device
US5439467A (en) 1991-12-03 1995-08-08 Vesica Medical, Inc. Suture passer
WO1993019678A3 (en) 1991-12-03 1993-12-23 Vesitec Medical Inc Surgical treatment of stress urinary incontinence
US5324327A (en) * 1991-12-17 1994-06-28 Cohen Donald M Low threshold cardiac pacing lead
GB9211085D0 (en) 1992-05-23 1992-07-08 Tippey Keith E Electrical stimulation
US5344439A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Catheter with retractable anchor mechanism
US5484445A (en) 1993-10-12 1996-01-16 Medtronic, Inc. Sacral lead anchoring system
US5400784A (en) 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
US5370670A (en) 1993-12-13 1994-12-06 Thomas Jefferson University Detrusor myoplasty and neuromuscular electrical stimulation of the urinary bladder
US5518504A (en) 1993-12-28 1996-05-21 American Medical Systems, Inc. Implantable sphincter system utilizing lifting means
US5603685A (en) 1994-07-01 1997-02-18 Tutrone, Jr.; Donald F. Inflatable vaginal pessary
US5571148A (en) 1994-08-10 1996-11-05 Loeb; Gerald E. Implantable multichannel stimulator
US5899909A (en) 1994-08-30 1999-05-04 Medscand Medical Ab Surgical instrument for treating female urinary incontinence
US5833595A (en) 1994-09-06 1998-11-10 Lin; Vernon Wen-Hau Treatment of excretory problems
US5569351A (en) 1994-11-14 1996-10-29 Cms Gilbreth Packaging Systems, Inc. Banding machine having improved film registration system
US5591217A (en) 1995-01-04 1997-01-07 Plexus, Inc. Implantable stimulator with replenishable, high value capacitive power source and method therefor
RU2161916C2 (en) 1995-10-09 2001-01-20 Этикон Инк. Surgical method and instrument for treating female enuresis
CA2229620A1 (en) 1995-11-24 1997-05-29 Advanced Bionics Corporation System and method for conditioning pelvic musculature using an implanted microstimulator
GB9601383D0 (en) 1996-01-24 1996-03-27 Lenadora Shantha J B Device for genuine stress incontinence in the female
EP1319422A3 (en) 1996-02-15 2004-01-28 Nihon Kohden Corporation An apparatus for treating urinary incontinence
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US6132384A (en) * 1996-06-26 2000-10-17 Medtronic, Inc. Sensor, method of sensor implant and system for treatment of respiratory disorders
US5755767A (en) * 1996-08-02 1998-05-26 Pacesetter, Inc. Anti-dislodgment and anti-perforation distal tip design for transvenous lead
DE69736719T2 (en) 1996-10-23 2007-09-20 Oratec Interventions, Inc., Menlo Park A device for treatment of intervertebral discs
DE69724386D1 (en) 1996-10-30 2003-10-02 Nihon Kohden Corp Stimulation device for the prevention of urinary incontinence
US6026326A (en) 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
DE69808614D1 (en) 1997-02-13 2002-11-14 Boston Scient Ltd Stabilization loop for use in minimally invasive surgery beck
WO1998037926A1 (en) 1997-02-26 1998-09-03 Alfred E. Mann Foundation For Scientific Research Battery-powered patient implantable device
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US5957965A (en) 1997-03-03 1999-09-28 Medtronic, Inc. Sacral medical electrical lead
US6039686A (en) 1997-03-18 2000-03-21 Kovac; S. Robert System and a method for the long term cure of recurrent urinary female incontinence
US6135945A (en) 1997-08-04 2000-10-24 Sultan; Hashem Anti-incontinence device
US5824027A (en) 1997-08-14 1998-10-20 Simon Fraser University Nerve cuff having one or more isolated chambers
US5957920A (en) 1997-08-28 1999-09-28 Isothermix, Inc. Medical instruments and techniques for treatment of urinary incontinence
US7628795B2 (en) 1997-09-24 2009-12-08 Atrium Medical Corporation Tunneling device for use with a graft
US6104955A (en) 1997-12-15 2000-08-15 Medtronic, Inc. Method and apparatus for electrical stimulation of the gastrointestinal tract
US6321116B1 (en) 1998-02-08 2001-11-20 Seung Kee Mo Electrical apparatus medical treatment using EMG envelope signal
US6382214B1 (en) 1998-04-24 2002-05-07 American Medical Systems, Inc. Methods and apparatus for correction of urinary and gynecological pathologies including treatment of male incontinence and female cystocele
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
EP1091688B1 (en) 1998-06-29 2006-04-12 The Procter & Gamble Company Disposable article having proactive sensor
US6149636A (en) 1998-06-29 2000-11-21 The Procter & Gamble Company Disposable article having proactive sensors
US6735474B1 (en) 1998-07-06 2004-05-11 Advanced Bionics Corporation Implantable stimulator system and method for treatment of incontinence and pain
US6941171B2 (en) 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US6027456A (en) 1998-07-10 2000-02-22 Advanced Neuromodulation Systems, Inc. Apparatus and method for positioning spinal cord stimulation leads
US6104960A (en) 1998-07-13 2000-08-15 Medtronic, Inc. System and method for providing medical electrical stimulation to a portion of the nervous system
US6002964A (en) 1998-07-15 1999-12-14 Feler; Claudio A. Epidural nerve root stimulation
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
US6042536A (en) 1998-08-13 2000-03-28 Contimed, Inc. Bladder sling
US6240316B1 (en) 1998-08-14 2001-05-29 Advanced Bionics Corporation Implantable microstimulation system for treatment of sleep apnea
EP1702587B1 (en) 1998-10-06 2008-12-10 Bio Control Medical, Ltd. Control of urge incontinence
WO2000019939A1 (en) 1998-10-06 2000-04-13 Bio Control Medical, Ltd. Control of urge incontinence
US6366814B1 (en) 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6505074B2 (en) 1998-10-26 2003-01-07 Birinder R. Boveja Method and apparatus for electrical stimulation adjunct (add-on) treatment of urinary incontinence and urological disorders using an external stimulator
US6356788B2 (en) 1998-10-26 2002-03-12 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for depression, migraine, neuropsychiatric disorders, partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US6964643B2 (en) 1998-11-18 2005-11-15 Nugyn, Inc. Devices and methods for treatment of incontinence
US6304786B1 (en) 1999-03-29 2001-10-16 Cardiac Pacemakers, Inc. Implantable lead with dissolvable coating for improved fixation and extraction
US20010025192A1 (en) 1999-04-29 2001-09-27 Medtronic, Inc. Single and multi-polar implantable lead for sacral nerve electrical stimulation
US6055456A (en) 1999-04-29 2000-04-25 Medtronic, Inc. Single and multi-polar implantable lead for sacral nerve electrical stimulation
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
DE60036873D1 (en) 1999-08-04 2007-12-06 Univ Melbourne Parkville A method and apparatus for treating incontinence
US20030028232A1 (en) 2000-01-20 2003-02-06 Medtronic, Inc. Method of lmplanting a medical electrical lead
GB2359256B (en) 2000-01-21 2004-03-03 Sofradim Production Percutaneous device for treating urinary stress incontinence in women using a sub-urethral tape
US7079882B1 (en) 2000-01-22 2006-07-18 Richard Schmidt Method and apparatus for quantifying nerve and neural-muscular integrity related to pelvic organs or pelvic floor functions
US6650943B1 (en) 2000-04-07 2003-11-18 Advanced Bionics Corporation Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction
JP4783490B2 (en) 2000-04-17 2011-09-28 東レ・ダウコーニング株式会社 Organopolysiloxane composition and method of preparation
EP1326675B1 (en) 2000-09-07 2011-04-13 Mann Medical Research Organization Apparatus for control of bowel function
US6418930B1 (en) 2000-11-14 2002-07-16 Mayo Foundation For Medical Education And Research Anatomic incontinence pessary
US6971393B1 (en) 2000-11-15 2005-12-06 George Mamo Minimally invasive method for implanting a sacral stimulation lead
KR20030068153A (en) 2000-11-20 2003-08-19 에디컨인코포레이티드 Surgical instrument and method for treating female urinary incontinence
US7407480B2 (en) 2001-07-27 2008-08-05 Ams Research Corporation Method and apparatus for correction of urinary and gynecological pathologies, including treatment of incontinence cystocele
US6652450B2 (en) 2001-01-23 2003-11-25 American Medical Systems, Inc. Implantable article and method for treating urinary incontinence using means for repositioning the implantable article
US6641525B2 (en) 2001-01-23 2003-11-04 Ams Research Corporation Sling assembly with secure and convenient attachment
US6952613B2 (en) 2001-01-31 2005-10-04 Medtronic, Inc. Implantable gastrointestinal lead with active fixation
US20020161382A1 (en) 2001-03-29 2002-10-31 Neisz Johann J. Implant inserted without bone anchors
US7695427B2 (en) 2002-04-26 2010-04-13 Torax Medical, Inc. Methods and apparatus for treating body tissue sphincters and the like
WO2003007885A3 (en) 2001-07-20 2003-04-10 Alfred E Mann Inst Biomed Eng Method and apparatus for the treatment of urinary tract dysfunction
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US6999819B2 (en) 2001-08-31 2006-02-14 Medtronic, Inc. Implantable medical electrical stimulation lead fixation method and apparatus
US6745079B2 (en) 2001-11-07 2004-06-01 Medtronic, Inc. Electrical tissue stimulation apparatus and method
US6712772B2 (en) 2001-11-29 2004-03-30 Biocontrol Medical Ltd. Low power consumption implantable pressure sensor
US6862480B2 (en) 2001-11-29 2005-03-01 Biocontrol Medical Ltd. Pelvic disorder treatment device
US7070556B2 (en) 2002-03-07 2006-07-04 Ams Research Corporation Transobturator surgical articles and methods
US20030199961A1 (en) 2002-04-03 2003-10-23 Bjorklund Vicki L. Method and apparatus for fixating a pacing lead of an implantable medical device
US6964699B1 (en) 2002-06-05 2005-11-15 The United States Of America As Represented By The Secretary Of The Navy Rocket motor exhaust scrubber
US7292890B2 (en) 2002-06-20 2007-11-06 Advanced Bionics Corporation Vagus nerve stimulation via unidirectional propagation of action potentials
US7860570B2 (en) 2002-06-20 2010-12-28 Boston Scientific Neuromodulation Corporation Implantable microstimulators and methods for unidirectional propagation of action potentials
US7203548B2 (en) 2002-06-20 2007-04-10 Advanced Bionics Corporation Cavernous nerve stimulation via unidirectional propagation of action potentials
US20040015205A1 (en) 2002-06-20 2004-01-22 Whitehurst Todd K. Implantable microstimulators with programmable multielectrode configuration and uses thereof
US7437193B2 (en) 2002-06-28 2008-10-14 Boston Scientific Neuromodulation Corporation Microstimulator employing improved recharging reporting and telemetry techniques
US20040242956A1 (en) 2002-07-29 2004-12-02 Scorvo Sean K. System for controlling fluid in a body
US20040068203A1 (en) 2002-10-03 2004-04-08 Scimed Life Systems, Inc. Sensing pressure
FR2847169B1 (en) 2002-11-20 2005-02-18 Vygon Apparatus for regional anesthesia and method for manufacturing the cannula of the device
US7328068B2 (en) 2003-03-31 2008-02-05 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by means of electrical stimulation of the pudendal and associated nerves, and the optional delivery of drugs in association therewith
US7343206B2 (en) * 2003-04-25 2008-03-11 Medtronic, Inc. Implantable medical lead and system, and method of use thereof
US20040248979A1 (en) 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
US20050038489A1 (en) 2003-08-14 2005-02-17 Grill Warren M. Electrode array for use in medical stimulation and methods thereof
US7303525B2 (en) 2003-08-22 2007-12-04 Ams Research Corporation Surgical article and methods for treating female urinary incontinence
US20080071321A1 (en) 2004-06-10 2008-03-20 Ndi Medical, Inc. Systems and methods of neuromodulation stimulation for the restoration of sexual function
US7347812B2 (en) 2003-09-22 2008-03-25 Ams Research Corporation Prolapse repair
US8751003B2 (en) 2004-02-11 2014-06-10 Ethicon, Inc. Conductive mesh for neurostimulation
US20080132969A1 (en) 2004-02-12 2008-06-05 Ndi Medical, Inc. Systems and methods for bilateral stimulation of left and right branches of the dorsal genital nerves to treat urologic dysfunctions
US8086318B2 (en) 2004-02-12 2011-12-27 Ndi Medical, Llc Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation
US7120499B2 (en) 2004-02-12 2006-10-10 Ndi Medical, Llc Portable percutaneous assemblies, systems and methods for providing highly selective functional or therapeutic neuromuscular stimulation
US7376467B2 (en) 2004-02-12 2008-05-20 Ndi Medical, Inc. Portable assemblies, systems and methods for providing functional or therapeutic neuromuscular stimulation
US8467875B2 (en) 2004-02-12 2013-06-18 Medtronic, Inc. Stimulation of dorsal genital nerves to treat urologic dysfunctions
US7343202B2 (en) 2004-02-12 2008-03-11 Ndi Medical, Llc. Method for affecting urinary function with electrode implantation in adipose tissue
US7500945B2 (en) 2004-04-30 2009-03-10 Ams Research Corporation Method and apparatus for treating pelvic organ prolapse
US7351197B2 (en) 2004-05-07 2008-04-01 Ams Research Corporation Method and apparatus for cystocele repair
WO2005123184A3 (en) 2004-06-10 2007-01-04 Ndi Medical Llc System and method for treating incontinence with implantation in adipose tissue
EP1885438A4 (en) 2005-05-13 2013-01-16 Ndi Medical Inc Systems for electrical stimulation of nerves in adipose tissue regions
EP1819394A1 (en) 2004-11-08 2007-08-22 Continence Control Systems International PTY Ltd. An implantable electrode arrangement
US7930039B2 (en) * 2005-01-07 2011-04-19 Medtronic, Inc. Implantable retention system and method
US7914437B2 (en) 2005-02-04 2011-03-29 Ams Research Corporation Transobturator methods for installing sling to treat incontinence, and related devices
JP2009506805A (en) * 2005-09-02 2009-02-19 コンティネンス コントロール システムズ インターナショナル プロプライエタリー リミテッド Smooth muscle implant for managing a medical condition
US20070100411A1 (en) 2005-10-27 2007-05-03 Medtronic, Inc. Implantable medical electrical stimulation lead fixation method and apparatus
EP1991133A2 (en) 2006-02-16 2008-11-19 AMS Research Corporation Surgical articles and methods for treating pelvic conditions
US8195296B2 (en) 2006-03-03 2012-06-05 Ams Research Corporation Apparatus for treating stress and urge incontinence
US20090157091A1 (en) 2006-04-04 2009-06-18 Ams Research Corporation Apparatus for Implanting Neural Stimulation Leads
WO2007126632A3 (en) 2006-04-04 2008-03-13 Ams Res Corp A tunneling instrument for and method of subcutaneously passing a medical electrical lead
US20070265675A1 (en) 2006-05-09 2007-11-15 Ams Research Corporation Testing Efficacy of Therapeutic Mechanical or Electrical Nerve or Muscle Stimulation
US8052731B2 (en) 2006-06-02 2011-11-08 Cardiac Pacemakers, Inc. Medical electrical lead with expandable fixation features
US20100076254A1 (en) 2006-06-05 2010-03-25 Ams Research Corporation Electrical muscle stimulation to treat fecal incontinence and/or pelvic prolapse
US7725197B2 (en) 2006-06-15 2010-05-25 Cardiac Pacemakers, Inc. Medical electrical lead with friction-enhancing fixation features
US8160710B2 (en) 2006-07-10 2012-04-17 Ams Research Corporation Systems and methods for implanting tissue stimulation electrodes in the pelvic region
US20090012592A1 (en) * 2006-07-10 2009-01-08 Ams Research Corporation Tissue anchor
US20100049289A1 (en) 2007-07-10 2010-02-25 Ams Research Corporation Tissue anchor
US7647113B2 (en) 2006-12-21 2010-01-12 Ams Research Corporation Electrode implantation in male external urinary sphincter
CA2696575A1 (en) * 2007-08-17 2009-02-26 Wilson-Cook Medical, Inc. Suture lock
US20090259280A1 (en) 2007-10-15 2009-10-15 Kevin Wilkin Electrical stimulation lead with bioerodible anchors and anchor straps
US8019443B2 (en) 2008-04-01 2011-09-13 Boston Scientific Neuromodulation Corporation Anchoring units for leads of implantable electric stimulation systems and methods of making and using

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3667477A (en) * 1966-11-25 1972-06-06 Canadian Patents Dev Implantable vesical stimulator
US3628538A (en) * 1968-09-18 1971-12-21 Nat Res Dev Apparatus for stimulating muscles controlled by the same muscles
US3650276A (en) * 1969-03-26 1972-03-21 Inst Demedicina Si Farmacie Method and apparatus, including a flexible electrode, for the electric neurostimulation of the neurogenic bladder
US3662758A (en) * 1969-06-30 1972-05-16 Mentor Corp Stimulator apparatus for muscular organs with external transmitter and implantable receiver
US3646940A (en) * 1969-07-15 1972-03-07 Univ Minnesota Implantable electronic stimulator electrode and method
US3640284A (en) * 1970-01-05 1972-02-08 Philip A De Langis Apparatus for electrotherapy of the pubococcygeus
US3870051A (en) * 1972-04-27 1975-03-11 Nat Res Dev Urinary control
US3866613A (en) * 1972-07-13 1975-02-18 Devices Implants Limited Pessary ring electrode system
US3941136A (en) * 1973-11-21 1976-03-02 Neuronyx Corporation Method for artificially inducing urination, defecation, or sexual excitation
US4023574A (en) * 1974-10-18 1977-05-17 Hans Nemec Electrostimulation method and apparatus
US3926178A (en) * 1975-01-17 1975-12-16 Alvin N Feldzamen Apparatus for aiding the voluntary exercising of sphincter muscles
US3983865A (en) * 1975-02-05 1976-10-05 Shepard Richard S Method and apparatus for myofunctional biofeedback
US3983881A (en) * 1975-05-21 1976-10-05 Telectronics Pty. Limited Muscle stimulator
US4010758A (en) * 1975-09-03 1977-03-08 Medtronic, Inc. Bipolar body tissue electrode
US4030509A (en) * 1975-09-30 1977-06-21 Mieczyslaw Mirowski Implantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilization
US4044774A (en) * 1976-02-23 1977-08-30 Medtronic, Inc. Percutaneously inserted spinal cord stimulation lead
US4106511A (en) * 1976-04-21 1978-08-15 Svenska Utvecklingsaktiebolaget Electrical stimulator in remedy of incontinence
US4136684A (en) * 1977-02-07 1979-01-30 Scattergood Mark G Linear electromyographic biofeedback system
US4139006A (en) * 1977-03-18 1979-02-13 Corey Arthur E Female incontinence device
US4222377A (en) * 1977-06-27 1980-09-16 American Medical Systems, Inc. Pressure regulated artificial sphincter systems
US4153059A (en) * 1977-10-25 1979-05-08 Minnesota Mining And Manufacturing Company Urinary incontinence stimulator system
US4157087A (en) * 1978-03-06 1979-06-05 Med General, Inc. Peripheral nerve stimulator
US4165750A (en) * 1978-03-18 1979-08-28 Aleev Leonid S Bioelectrically controlled electric stimulator of human muscles
US4177819A (en) * 1978-03-30 1979-12-11 Kofsky Harvey I Muscle stimulating apparatus
US4290420A (en) * 1980-06-09 1981-09-22 Alberto Manetta Stress incontinence diagnostic and treatment device
US4431001A (en) * 1980-09-17 1984-02-14 Crafon Medical Ab Stimulator system
US4387719A (en) * 1980-10-23 1983-06-14 Gorenje Tovarna Gospodinjske Opreme N.Sol.O. Velenje Control circuit of a therapeutic stimulator for the urinary incontinence
US4457299A (en) * 1981-02-06 1984-07-03 Cornwell George H I Incontinence control devices
US4406288A (en) * 1981-04-06 1983-09-27 Hugh P. Cash Bladder control device and method
US4402328A (en) * 1981-04-28 1983-09-06 Telectronics Pty. Limited Crista terminalis atrial electrode lead
US4750494A (en) * 1981-05-12 1988-06-14 Medtronic, Inc. Automatic implantable fibrillation preventer
US4414986A (en) * 1982-01-29 1983-11-15 Medtronic, Inc. Biomedical stimulation lead
US4688575A (en) * 1982-03-12 1987-08-25 Duvall Wilbur E Muscle contraction stimulation
US4492233A (en) * 1982-09-14 1985-01-08 Wright State University Method and apparatus for providing feedback-controlled muscle stimulation
US4731083A (en) * 1982-09-21 1988-03-15 The Johns Hopkins University Manually actuated hydraulic sphincter
US4571749A (en) * 1982-09-21 1986-02-25 The Johns Hopkins University Manually actuated hydraulic sphincter
US4568339A (en) * 1982-11-05 1986-02-04 Craig Medical Products, Limited Female incontinence device
US4542753A (en) * 1982-12-22 1985-09-24 Biosonics, Inc. Apparatus and method for stimulating penile erectile tissue
US4515167A (en) * 1983-02-28 1985-05-07 Hochman Joel S Device for the development, training and rehabilitation of the pubococcygeal and related perineal musculature of the female
US4580578A (en) * 1983-05-06 1986-04-08 Richard Wolf Gmbh Device for the treatment of female urinary incontinence
US4585005A (en) * 1984-04-06 1986-04-29 Regents Of University Of California Method and pacemaker for stimulating penile erection
US4607639A (en) * 1984-05-18 1986-08-26 Regents Of The University Of California Method and system for controlling bladder evacuation
US4771779A (en) * 1984-05-18 1988-09-20 The Regents Of The University Of California System for controlling bladder evacuation
US4703755A (en) * 1984-05-18 1987-11-03 The Regents Of The University Of California Control system for the stimulation of two bodily functions
US4739764A (en) * 1984-05-18 1988-04-26 The Regents Of The University Of California Method for stimulating pelvic floor muscles for regulating pelvic viscera
US4602624A (en) * 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4628942A (en) * 1984-10-11 1986-12-16 Case Western Reserve University Asymmetric shielded two electrode cuff
US4569351A (en) * 1984-12-20 1986-02-11 University Of Health Sciences/The Chicago Medical School Apparatus and method for stimulating micturition and certain muscles in paraplegic mammals
US4785828A (en) * 1986-10-06 1988-11-22 Empi, Inc. Vaginal stimulator for controlling urinary incontinence in women
US4848005A (en) * 1987-02-03 1989-07-18 D.E.A. Digital Electronic Automation S.P.A. Rearrangeable supporting and positioning fixture, particularly for parts measurable on a gauging machine
US4941874A (en) * 1987-08-11 1990-07-17 Hoechst Aktiengesellschaft Device for the administration of implants
US5082006A (en) * 1987-09-15 1992-01-21 Linda Jonasson Device for preventing involuntary micturition
US4881526A (en) * 1988-05-27 1989-11-21 Empi, Inc. Intravaginal electrode and stimulation system for controlling female urinary incontinence
US4913164A (en) * 1988-09-27 1990-04-03 Intermedics, Inc. Extensible passive fixation mechanism for lead assembly of an implantable cardiac stimulator
US5112344A (en) * 1988-10-04 1992-05-12 Petros Peter E Surgical instrument and method of utilization of such
US5094242A (en) * 1988-11-07 1992-03-10 Regents Of The University Of California Implantable nerve stimulation device
US5013292A (en) * 1989-02-24 1991-05-07 R. Laborie Medical Corporation Surgical correction of female urinary stress incontinence and kit therefor
US5019032A (en) * 1990-04-03 1991-05-28 Robertson Jack R Refined suspension procedure with implement for treating female stress incontinence
US5103835A (en) * 1990-05-02 1992-04-14 Nihon Kohden Corporation Impedance monitoring device for preventing urinary incontinence
US5285781A (en) * 1990-05-26 1994-02-15 Stiwell S. A. Electrical neuromuscular stimulation device
US5199430A (en) * 1991-03-11 1993-04-06 Case Western Reserve University Micturitional assist device
US5452719A (en) * 1991-07-23 1995-09-26 Eisman; Eugene Multiple electrode myographic probe and method
US5312439A (en) * 1991-12-12 1994-05-17 Loeb Gerald E Implantable device having an electrolytic storage electrode
US5193539A (en) * 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5405367A (en) * 1991-12-18 1995-04-11 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5324316A (en) * 1991-12-18 1994-06-28 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5358514A (en) * 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5193540A (en) * 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5330507A (en) * 1992-04-24 1994-07-19 Medtronic, Inc. Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias
US5324324A (en) * 1992-10-13 1994-06-28 Siemens Pacesetter, Inc. Coated implantable stimulation electrode and lead
US5291902A (en) * 1993-01-11 1994-03-08 Brent Carman Incontinence treatment
US5411548A (en) * 1993-01-11 1995-05-02 Carman; Brent Method of varying appropriate muscle strength of a person to alleviate urinary or fecal urgency or incontinence or vaginal or bladder spasms
US5423329A (en) * 1994-04-15 1995-06-13 Rehab Centers Of America, Inc. Method of treatment for urinary incontinence
US5417226A (en) * 1994-06-09 1995-05-23 Juma; Saad Female anti-incontinence device
US6243607B1 (en) * 1996-09-05 2001-06-05 University Technologies International Inc. Gastro-intestinal electrical pacemaker
US5954761A (en) * 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US20030060868A1 (en) * 1997-12-24 2003-03-27 Cardiac Pacemakers, Inc. High impedance electrode tip
US5931864A (en) * 1998-02-20 1999-08-03 Cardiac Pacemakers, Inc. Coronary venous lead having fixation mechanism
US6178356B1 (en) * 1998-02-20 2001-01-23 Cardiac Pacemakers, Inc. Coronary venous lead having fixation mechanism
US6141594A (en) * 1998-07-22 2000-10-31 Cardiac Pacemakers, Inc. Single pass lead and system with active and passive fixation elements
US6397109B1 (en) * 1998-12-23 2002-05-28 Avio Maria Perna Single pass multiple chamber implantable electro-catheter for multi-site electrical therapy of up to four cardiac chambers, indicated in the treatment of such pathologies as atrial fibrillation and congestive/dilate cardio myopathy
US6161029A (en) * 1999-03-08 2000-12-12 Medtronic, Inc. Apparatus and method for fixing electrodes in a blood vessel
US6582441B1 (en) * 2000-02-24 2003-06-24 Advanced Bionics Corporation Surgical insertion tool
US6612977B2 (en) * 2001-01-23 2003-09-02 American Medical Systems Inc. Sling delivery system and method of use
US20030019961A1 (en) * 2001-07-20 2003-01-30 Horst Hohnen Method and device for the in situ disposal of incontinence articles
US20030023296A1 (en) * 2001-07-25 2003-01-30 Osypka Thomas P. Implantable coronary sinus lead with mapping capabilities
US7613516B2 (en) * 2001-11-29 2009-11-03 Ams Research Corporation Pelvic disorder treatment device
US6911003B2 (en) * 2002-03-07 2005-06-28 Ams Research Corporation Transobturator surgical articles and methods
US7771345B1 (en) * 2002-12-03 2010-08-10 O'donnell Pat D Surgical instrument for treating female urinary stress incontinence
US20050149156A1 (en) * 2003-12-24 2005-07-07 Imad Libbus Lead for stimulating the baroreceptors in the pulmonary artery
US20050228346A1 (en) * 2004-04-09 2005-10-13 Cook Vascular Incorporated Modular hemostatic valve
US7319905B1 (en) * 2004-11-30 2008-01-15 Pacesetter, Inc. Passive fixation mechanism for epicardial sensing and stimulation lead placed through pericardial access
US20060241733A1 (en) * 2005-04-25 2006-10-26 Cardiac Pacemakers, Inc. Atrial pacing lead
US20070043416A1 (en) * 2005-08-19 2007-02-22 Cardiac Pacemakers, Inc. Implantable electrode array
US20070179559A1 (en) * 2006-01-31 2007-08-02 Medtronic, Inc. Electrical stimulation to alleviate chronic pelvic pain
US20070253997A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Drug delivery to alleviate chronic pelvic pain
US20070255341A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Electrical stimulation of ilioinguinal nerve to alleviate chronic pelvic pain
US20070253998A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Drug delivery to iliohypogastric nerve to alleviate chronic pelvic pain
US20070255333A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Neuromodulation therapy for perineal or dorsal branch of pudendal nerve

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090036946A1 (en) * 2001-11-29 2009-02-05 American Medical Systems, Inc. Pelvic disorder treatments
US9889298B2 (en) 2006-03-03 2018-02-13 Astora Women's Health, Llc Electrode sling for treating stress and urge incontinence
US20090043356A1 (en) * 2006-03-03 2009-02-12 Ams Research Corporation Electrode Sling for Treating Stress and Urge Incontinence
US8195296B2 (en) 2006-03-03 2012-06-05 Ams Research Corporation Apparatus for treating stress and urge incontinence
US8170686B2 (en) * 2006-03-14 2012-05-01 Boston Scientific Scimed, Inc. Heatable sling support for an anatomical location
US20070219606A1 (en) * 2006-03-14 2007-09-20 Boston Scientific Scimed, Inc. Heatable sling support for an anatomical location
US20070265675A1 (en) * 2006-05-09 2007-11-15 Ams Research Corporation Testing Efficacy of Therapeutic Mechanical or Electrical Nerve or Muscle Stimulation
US8160710B2 (en) 2006-07-10 2012-04-17 Ams Research Corporation Systems and methods for implanting tissue stimulation electrodes in the pelvic region
US8311647B2 (en) 2007-01-30 2012-11-13 Cardiac Pacemakers, Inc. Direct delivery system for transvascular lead
US8412350B2 (en) 2007-01-30 2013-04-02 Cardiac Pacemakers, Inc. Neurostimulating lead having a stent-like anchor
US9427573B2 (en) 2007-07-10 2016-08-30 Astora Women's Health, Llc Deployable electrode lead anchor
US8774942B2 (en) 2007-07-10 2014-07-08 Ams Research Corporation Tissue anchor
US9539433B1 (en) 2009-03-18 2017-01-10 Astora Women's Health, Llc Electrode implantation in a pelvic floor muscular structure
US8380312B2 (en) 2009-12-31 2013-02-19 Ams Research Corporation Multi-zone stimulation implant system and method
US9427220B2 (en) 2010-01-20 2016-08-30 Micro Interventional Devices, Inc. Tissue repair implant and delivery device and method
US9138211B2 (en) 2010-01-20 2015-09-22 Micro Interventional Devices, Inc. Tissue repair implant and delivery device and method
US9050065B2 (en) 2010-01-20 2015-06-09 Micro Interventional Devices, Inc. Tissue repair implant and delivery device and method
US9220887B2 (en) 2011-06-09 2015-12-29 Astora Women's Health LLC Electrode lead including a deployable tissue anchor
WO2013036399A3 (en) * 2011-09-08 2013-06-27 Ams Research Corporation Implantable electrode assembly
US9731112B2 (en) 2011-09-08 2017-08-15 Paul J. Gindele Implantable electrode assembly
CN105246417A (en) * 2013-03-15 2016-01-13 微介入设备公司 Tissue closure device and method
WO2014146000A3 (en) * 2013-03-15 2014-11-06 Micro Interventional Devices, Inc. Tissue closure device and method

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WO2010107751A8 (en) 2011-04-21 application
US8774942B2 (en) 2014-07-08 grant
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EP2974769A3 (en) 2016-04-13 application

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