US20080153804A1 - Gamma D-Crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it - Google Patents

Gamma D-Crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it Download PDF

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US20080153804A1
US20080153804A1 US12/072,887 US7288708A US2008153804A1 US 20080153804 A1 US20080153804 A1 US 20080153804A1 US 7288708 A US7288708 A US 7288708A US 2008153804 A1 US2008153804 A1 US 2008153804A1
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crystalline form
ivabradine hydrochloride
ivabradine
rhythm disturbances
hydrochloride
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US12/072,887
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Stephane Horvath
Marie-Noelle Auguste
Gerard Damien
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Laboratoires Servier SAS
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Priority to US12/583,917 priority patent/US7872001B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Definitions

  • the present invention relates to the new yd-crystalline form of ivabradine hydrochloride of formula (I), to a process for its preparation and to pharmaceutical compositions containing it.
  • Ivabradine, and addition salts thereof with a pharmaceutically acceptable acid, and more especially its hydrochloride have very valuable pharmacological and therapeutic properties, especially bradycardic properties, making those compounds useful in the treatment or prevention of various clinical situations of myocardial ischaemia such as angina pectoris, myocardial infarct and associated rhythm disturbances, and also in various pathologies involving rhythm disturbances, especially supraventricular rhythm disturbances, and in heart failure.
  • the present invention relates to the ⁇ d-crystalline form of ivabradine hydrochloride, which is characterised by the following powder X-ray diffraction diagram measured using a PANalytical X'Pert Pro diffractometer together with an X'Celerator detector and expressed in terms of ray position (Bragg's angle 2 theta, expressed in degrees), ray height (expressed in counts), ray area (expressed in counts ⁇ degrees), ray width at half-height (“FWHM”, expressed in degrees) and interplanar distance d (expressed in ⁇ ):
  • Angle Area 2 theta Height (counts ⁇ FWHM Interplanar Ray no. (degrees) (counts) degrees) (degrees) distance ( ⁇ ) 1 4.3 1077 124 0.1171 20.633 2 6.9 132 70 0.5353 12.787 3 8.4 269 35 0.1338 10.482 4 10.6 322 26 0.0836 8.310 5 11.9 733 97 0.1338 7.414 6 12.5 1406 278 0.2007 7.069 7 13.4 2975 442 0.1506 6.619 8 14.4 825 122 0.1506 6.134 9 15.8 1036 205 0.2007 5.598 10 16.3 540 107 0.2007 5.450 11 16.9 1007 183 0.184 5.233 12 17.8 499 58 0.1171 4.978 13 18.9 1062 140 0.1338 4.686 14 19.8 570 85 0.1506 4.485 15 20.2 549 63 0.1171 4.399 16 20.9 2565 635 0.2509 4.241 17 21.6 531 105 0.2007 4.104 18 22.3 213 35 0.1673
  • the invention relates also to a process for the preparation of the ⁇ d-crystalline form of ivabradine hydrochloride, which process is characterised in that a mixture of ivabradine hydrochloride and 2-ethoxyethanol, a mixture of ivabradine hydrochloride, 2-ethoxyethanol and water, or a mixture of ivabradine hydrochloride, ethanol and water is heated until dissolution is complete and is then cooled until crystallisation is complete, and the crystals obtained are collected by filtration and dehydrated.
  • the invention relates also to pharmaceutical compositions comprising as active ingredient the ⁇ d-crystalline form of ivabradine hydrochloride together with one or more appropriate, inert, non-toxic excipients.
  • pharmaceutical compositions according to the invention there may be mentioned more especially those that are suitable for oral, parenteral (intravenous or subcutaneous) or nasal administration, tablets or dragées, sublingual tablets, gelatin capsules, lozenges, suppositories, creams, ointments, dermal gels, injectable preparations, drinkable suspensions.
  • the useful dosage can be varied according to the nature and severity of the disorder, the administration route and the age and weight of the patient. That dosage varies from 1 to 500 mg per day in one or more administrations.
  • the product thereby obtained is dehydrated by progressively heating at a rate of 5° C./min up to a temperature of 80° C.
  • Angle Area 2 theta Height (counts ⁇ FWHM Interplanar Ray no. (degrees) (counts) degrees) (degrees) distance ( ⁇ ) 1 4.3 1077 124 0.1171 20.633 2 6.9 132 70 0.5353 12.787 3 8.4 269 35 0.1338 10.482 4 10.6 322 26 0.0836 8.310 5 11.9 733 97 0.1338 7.414 6 12.5 1406 278 0.2007 7.069 7 13.4 2975 442 0.1506 6.619 8 14.4 825 122 0.1506 6.134 9 15.8 1036 205 0.2007 5.598 10 16.3 540 107 0.2007 5.450 11 16.9 1007 183 0.184 5.233 12 17.8 499 58 0.1171 4.978 13 18.9 1062 140 0.1338 4.686 14 19.8 570 85 0.1506 4.485 15 20.2 549 63 0.1171 4.399 16 20.9 2565 635 0.2509 4.241 17 21.6 531 105 0.2007 4.104 18 22.3 213 35 0.1673

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
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  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

A γd-Crystalline form of ivabradine hydrochloride of formula (I):
Figure US20080153804A1-20080626-C00001
characterised by its powder X-ray diffraction data.
Medicinal products containing the same which are useful as bradycardics.

Description

  • The present invention relates to the new yd-crystalline form of ivabradine hydrochloride of formula (I), to a process for its preparation and to pharmaceutical compositions containing it.
  • Figure US20080153804A1-20080626-C00002
  • Ivabradine, and addition salts thereof with a pharmaceutically acceptable acid, and more especially its hydrochloride, have very valuable pharmacological and therapeutic properties, especially bradycardic properties, making those compounds useful in the treatment or prevention of various clinical situations of myocardial ischaemia such as angina pectoris, myocardial infarct and associated rhythm disturbances, and also in various pathologies involving rhythm disturbances, especially supraventricular rhythm disturbances, and in heart failure.
  • The preparation and therapeutic use of ivabradine and addition salts thereof with a pharmaceutically acceptable acid, and more especially its hydrochloride, have been described in the European patent specification EP 0 534 859.
  • In view of the pharmaceutical value of this compound, it has been of prime importance to obtain it with excellent purity. It has also been important to be able to synthesise it by means of a process that can readily be converted to the industrial scale, especially in a form that allows rapid filtration and drying. Finally, that form had to be perfectly reproducible, easily formulated and sufficiently stable to allow its storage for long periods without particular requirements for temperature, light or oxygen level.
  • The patent specification EP 0 534 859 describes a synthesis process for ivabradine and its hydrochloride. However, that document does not specify the conditions for obtaining ivabradine in a form that exhibits those characteristics in a reproducible manner.
  • The Applicant has now found that a particular salt of ivabradine, the hydrochloride, can be obtained in a crystalline form that is well defined and that exhibits valuable characteristics of stability and processability.
  • More specifically, the present invention relates to the γd-crystalline form of ivabradine hydrochloride, which is characterised by the following powder X-ray diffraction diagram measured using a PANalytical X'Pert Pro diffractometer together with an X'Celerator detector and expressed in terms of ray position (Bragg's angle 2 theta, expressed in degrees), ray height (expressed in counts), ray area (expressed in counts×degrees), ray width at half-height (“FWHM”, expressed in degrees) and interplanar distance d (expressed in Å):
  • Angle Area
    2 theta Height (counts × FWHM Interplanar
    Ray no. (degrees) (counts) degrees) (degrees) distance (Å)
    1 4.3 1077 124 0.1171 20.633
    2 6.9 132 70 0.5353 12.787
    3 8.4 269 35 0.1338 10.482
    4 10.6 322 26 0.0836 8.310
    5 11.9 733 97 0.1338 7.414
    6 12.5 1406 278 0.2007 7.069
    7 13.4 2975 442 0.1506 6.619
    8 14.4 825 122 0.1506 6.134
    9 15.8 1036 205 0.2007 5.598
    10 16.3 540 107 0.2007 5.450
    11 16.9 1007 183 0.184 5.233
    12 17.8 499 58 0.1171 4.978
    13 18.9 1062 140 0.1338 4.686
    14 19.8 570 85 0.1506 4.485
    15 20.2 549 63 0.1171 4.399
    16 20.9 2565 635 0.2509 4.241
    17 21.6 531 105 0.2007 4.104
    18 22.3 213 35 0.1673 3.981
    19 23.4 278 27 0.1004 3.807
    20 24.1 1404 185 0.1338 3.694
    21 24.4 1526 176 0.1171 3.650
    22 24.8 676 100 0.1506 3.591
    23 25.4 702 139 0.2007 3.504
    24 26.2 1737 401 0.2342 3.403
    25 26.8 258 51 0.2007 3.331
    26 27.2 182 24 0.1338 3.282
    27 27.9 838 249 0.3011 3.193
    28 29.1 152 20 0.1338 3.071
  • The invention relates also to a process for the preparation of the γd-crystalline form of ivabradine hydrochloride, which process is characterised in that a mixture of ivabradine hydrochloride and 2-ethoxyethanol, a mixture of ivabradine hydrochloride, 2-ethoxyethanol and water, or a mixture of ivabradine hydrochloride, ethanol and water is heated until dissolution is complete and is then cooled until crystallisation is complete, and the crystals obtained are collected by filtration and dehydrated.
      • In the crystallisation process according to the invention it is possible to use ivabradine hydrochloride obtained by any process, for example ivabradine hydrochloride obtained by the preparation process described in patent specification EP 0 534 859.
      • The solution may advantageously be seeded during the cooling step.
  • The invention relates also to pharmaceutical compositions comprising as active ingredient the γd-crystalline form of ivabradine hydrochloride together with one or more appropriate, inert, non-toxic excipients. Among the pharmaceutical compositions according to the invention, there may be mentioned more especially those that are suitable for oral, parenteral (intravenous or subcutaneous) or nasal administration, tablets or dragées, sublingual tablets, gelatin capsules, lozenges, suppositories, creams, ointments, dermal gels, injectable preparations, drinkable suspensions.
  • The useful dosage can be varied according to the nature and severity of the disorder, the administration route and the age and weight of the patient. That dosage varies from 1 to 500 mg per day in one or more administrations.
  • The following Examples illustrate the invention.
  • The X-ray powder diffraction spectrum was measured under the following experimental conditions:
    • PANalytical X'Pert Pro diffractometer, X'Celerator detector, temperature-regulated chamber,
      • voltage 45 kV, intensity 40 mA,
    • mounting θ-θ,
    • nickel (Kβ) filter,
    • incident-beam and diffracted-beam Soller slit: 0.04 rad,
    • fixed angle of divergence slits : ⅛°,
    • mask: 10 mm,
    • antiscatter slit: ¼°,
    • measurement mode : continuous from 3° to 30°, in increments of 0.017°,
    • measurement time per step : 19.7 s,
    • total time : 4 min 32 s,
    • measurement speed : 0.108°/s,
    • measurement temperature : ambient.
    EXAMPLE 1 γd-Crystalline Form of Ivabradine Hydrochloride
  • 40 ml of 2-ethoxyethanol are preheated to 80° C., and then 8.4 g of ivabradine hydrochloride obtained according to the process described in the patent specification EP 0 534 859 are added in portions, with stirring, and the mixture is heated at 80° C. until dissolution is complete. After returning to ambient temperature, the solution is stored for 8 days, and then the crystals formed are collected by filtration and rinsed with cyclohexane.
  • The product thereby obtained is dehydrated by progressively heating at a rate of 5° C./min up to a temperature of 80° C.
  • X-ray Powder Diffraction Diagram
  • The X-ray powder diffraction profile (diffraction angles) of the γd-form of ivabradine hydrochloride is given by the significant rays collated in the following table:
  • Angle Area
    2 theta Height (counts × FWHM Interplanar
    Ray no. (degrees) (counts) degrees) (degrees) distance (Å)
    1 4.3 1077 124 0.1171 20.633
    2 6.9 132 70 0.5353 12.787
    3 8.4 269 35 0.1338 10.482
    4 10.6 322 26 0.0836 8.310
    5 11.9 733 97 0.1338 7.414
    6 12.5 1406 278 0.2007 7.069
    7 13.4 2975 442 0.1506 6.619
    8 14.4 825 122 0.1506 6.134
    9 15.8 1036 205 0.2007 5.598
    10 16.3 540 107 0.2007 5.450
    11 16.9 1007 183 0.184 5.233
    12 17.8 499 58 0.1171 4.978
    13 18.9 1062 140 0.1338 4.686
    14 19.8 570 85 0.1506 4.485
    15 20.2 549 63 0.1171 4.399
    16 20.9 2565 635 0.2509 4.241
    17 21.6 531 105 0.2007 4.104
    18 22.3 213 35 0.1673 3.981
    19 23.4 278 27 0.1004 3.807
    20 24.1 1404 185 0.1338 3.694
    21 24.4 1526 176 0.1171 3.650
    22 24.8 676 100 0.1506 3.591
    23 25.4 702 139 0.2007 3.504
    24 26.2 1737 401 0.2342 3.403
    25 26.8 258 51 0.2007 3.331
    26 27.2 182 24 0.1338 3.282
    27 27.9 838 249 0.3011 3.193
    28 29.1 152 20 0.1338 3.071
    • EXAMPLE 2 Pharmaceutical Composition
  • Formula for the preparation of 1000 tablets each containing 5 mg of ivabradine base:
    • Compound of Example 1 5.39 g
    • Maize starch 20 g
    • Anhydrous colloidal silica 0.2 g
    • Mannitol 63.91 g
    • PVP 10 g
    • Magnesium stearate 0.5 g

Claims (7)

1. A γd-Crystalline form of ivabradine hydrochloride of formula (1):
Figure US20080153804A1-20080626-C00003
2. The γd-Crystalline form of ivabradine hydrochloride of claim 1 having a powder X-ray diffraction diagram exhibiting peaks at 12.5, 13.4, 20.9, 24.4 and 26.2 deg 2 theta.
3. A pharmaceutical composition comprising as active ingredient the γd-crystalline form of ivabradine hydrochloride of claim 1, in combination with one or more pharmaceutically acceptable, inert, non-toxic carriers.
4. A method for treating or preventing a condition requiring a bradycardic, such method comprising administering to a living animal body, including a human, a therapeutically effective amount of the γd-crystalline form of ivabradine hydrochloride of claim 1.
5. A method for treating or preventing clinical situations of myocardial ischaemia and/or 15 a condition involving rhythm disturbances such method comprising administering to a living animal body, including a human, a therapeutically effective amount of the γd-crystalline form of ivabradine hydrochloride of claim 1.
6. The method of claim 5, wherein the clinical situation of myocardial ischaemia is selected from angina pectoris and myocardial infarct and associated rhythm disturbances.
7. The method of claim 5, wherein the condition involving rhythm disturbances is selected from supra ventricular rhythm disturbances and heart failure.
US12/072,887 2005-02-28 2008-02-28 Gamma D-Crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it Abandoned US20080153804A1 (en)

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US12/583,917 US7872001B2 (en) 2005-02-28 2009-08-27 Gamma d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it

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FR0501990A FR2882556B1 (en) 2005-02-28 2005-02-28 CRYSTALLINE GAMMA D FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR05.01990 2005-02-28
US11/359,262 US7361651B2 (en) 2005-02-28 2006-02-22 γd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
US12/072,887 US20080153804A1 (en) 2005-02-28 2008-02-28 Gamma D-Crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it

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Cited By (1)

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US8212026B2 (en) 2007-05-30 2012-07-03 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof

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FR2882555B1 (en) * 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
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FR2882554B1 (en) * 2005-02-28 2007-05-04 Servier Lab IVABRADINE HYDROCHLORIDE BETA D-CRYSTALLINE FORM, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891827B1 (en) * 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE DELTAD FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891826B1 (en) * 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE FORM 6 OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
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CN101353325B (en) * 2007-07-27 2011-11-09 上海优拓医药科技有限公司 Stable Ivabradine crystal and preparation thereof
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