US20070026012A1 - Compositions and methods for monitoring and altering protein folding and solubility - Google Patents

Compositions and methods for monitoring and altering protein folding and solubility Download PDF

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Publication number
US20070026012A1
US20070026012A1 US11/194,635 US19463505A US2007026012A1 US 20070026012 A1 US20070026012 A1 US 20070026012A1 US 19463505 A US19463505 A US 19463505A US 2007026012 A1 US2007026012 A1 US 2007026012A1
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United States
Prior art keywords
protein
cells
gene
sequence
cell
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Abandoned
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US11/194,635
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English (en)
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Matthew DeLisa
Adam Fisher
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Cornell University
Cornell Research Foundation Inc
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Cornell University
Cornell Research Foundation Inc
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Application filed by Cornell University, Cornell Research Foundation Inc filed Critical Cornell University
Priority to US11/194,635 priority Critical patent/US20070026012A1/en
Assigned to NATIONAL SCIENCE FOUNDATION reassignment NATIONAL SCIENCE FOUNDATION CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). Assignors: CORNELL UNIVERSITY
Assigned to CORNELL RESEARCH FOUNDATION, INC. reassignment CORNELL RESEARCH FOUNDATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DELISA, MATTHEW P., FISHER, ADAM CHARLES
Priority to EP06789138.2A priority patent/EP1915390B1/fr
Priority to CA002617792A priority patent/CA2617792A1/fr
Priority to EP11181473.7A priority patent/EP2418280B1/fr
Priority to PCT/US2006/029998 priority patent/WO2007016591A2/fr
Priority to AU2006275415A priority patent/AU2006275415B2/en
Publication of US20070026012A1 publication Critical patent/US20070026012A1/en
Assigned to CORNELL RESEARCH FOUNDATION, INC. reassignment CORNELL RESEARCH FOUNDATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DELISA, MATTHEW P., FISHER, ADAM CHARLES
Priority to US12/152,482 priority patent/US8987173B2/en
Assigned to CORNELL RESEARCH FOUNDATION, INC. reassignment CORNELL RESEARCH FOUNDATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DELISA, MATHEW P., FISHER, ADAM CHARLES
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
US11/194,635 2005-08-01 2005-08-01 Compositions and methods for monitoring and altering protein folding and solubility Abandoned US20070026012A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US11/194,635 US20070026012A1 (en) 2005-08-01 2005-08-01 Compositions and methods for monitoring and altering protein folding and solubility
AU2006275415A AU2006275415B2 (en) 2005-08-01 2006-07-31 Compositions and methods for monitoring and altering protein folding and solubility
PCT/US2006/029998 WO2007016591A2 (fr) 2005-08-01 2006-07-31 Compositions et methodes destinees a surveiller et modifier le repliement et la solubilite proteiques
EP11181473.7A EP2418280B1 (fr) 2005-08-01 2006-07-31 Compositions et procédés de surveillance et d'altération de plissement et de solubilité de protéines
CA002617792A CA2617792A1 (fr) 2005-08-01 2006-07-31 Compositions et methodes destinees a surveiller et modifier le repliement et la solubilite proteiques
EP06789138.2A EP1915390B1 (fr) 2005-08-01 2006-07-31 Compositions et methodes destinees a surveiller et modifier le repliement et la solubilite proteiques
US12/152,482 US8987173B2 (en) 2005-08-01 2008-05-14 Compositions and methods for monitoring and altering protein folding and solubility

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/194,635 US20070026012A1 (en) 2005-08-01 2005-08-01 Compositions and methods for monitoring and altering protein folding and solubility

Related Child Applications (1)

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US12/152,482 Division US8987173B2 (en) 2005-08-01 2008-05-14 Compositions and methods for monitoring and altering protein folding and solubility

Publications (1)

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US20070026012A1 true US20070026012A1 (en) 2007-02-01

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US11/194,635 Abandoned US20070026012A1 (en) 2005-08-01 2005-08-01 Compositions and methods for monitoring and altering protein folding and solubility
US12/152,482 Expired - Fee Related US8987173B2 (en) 2005-08-01 2008-05-14 Compositions and methods for monitoring and altering protein folding and solubility

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US12/152,482 Expired - Fee Related US8987173B2 (en) 2005-08-01 2008-05-14 Compositions and methods for monitoring and altering protein folding and solubility

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US (2) US20070026012A1 (fr)
EP (2) EP2418280B1 (fr)
AU (1) AU2006275415B2 (fr)
CA (1) CA2617792A1 (fr)
WO (1) WO2007016591A2 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
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US20080287315A1 (en) * 2005-08-01 2008-11-20 Cornell University Compositions & methods for monitoring and altering protein folding and solubility
US20090220952A1 (en) * 2005-08-22 2009-09-03 Cornell Research Foundation, Inc. Compositions And Methods For Analyzing Protein Interactions
US20090249101A1 (en) * 2006-09-11 2009-10-01 Apple Inc. Method and system for controlling power provided to an accessory
US20100144546A1 (en) * 2007-01-12 2010-06-10 Cornell University Genetic selection for protein folding and solubility in the bacterial periplasm
US20100172877A1 (en) * 2009-01-08 2010-07-08 Yale University Compositions and methods of use of an oncolytic vesicular stomatitis virus
WO2011032003A1 (fr) 2009-09-10 2011-03-17 Yale University Immunisation pour réduire la neurotoxicité pendant un traitement avec des virus cytolytiques
WO2011056993A1 (fr) 2009-11-04 2011-05-12 Yale University Compositions et procédés destinés à traiter le cancer par des virus oncolytiques atténués
US8536390B2 (en) 2010-03-18 2013-09-17 Syntroleum Corporation, A Delaware Corporation Profitable method for carbon capture and storage
US8558042B2 (en) 2008-06-04 2013-10-15 Syntroleum Corporation Biorenewable naphtha
US8575409B2 (en) 2007-12-20 2013-11-05 Syntroleum Corporation Method for the removal of phosphorus
US8969259B2 (en) 2013-04-05 2015-03-03 Reg Synthetic Fuels, Llc Bio-based synthetic fluids
WO2015077714A1 (fr) 2013-11-22 2015-05-28 Yale University Compositions de virus vsv chimérique et procédés pour les utiliser pour le traitement du cancer
US9133080B2 (en) 2008-06-04 2015-09-15 Reg Synthetic Fuels, Llc Biorenewable naphtha
US20160003844A1 (en) * 2012-08-22 2016-01-07 Mogam Biotechnology Research Institute Screening and engineering method of super-stable immunoglobulin variable domains and their uses
WO2016020661A1 (fr) * 2014-08-07 2016-02-11 The University Of Sussex Maladie d'alzheimer
US9328303B2 (en) 2013-03-13 2016-05-03 Reg Synthetic Fuels, Llc Reducing pressure drop buildup in bio-oil hydroprocessing reactors
CN106589067A (zh) * 2016-12-21 2017-04-26 生工生物工程（上海）股份有限公司 一种信号肽及其编码基因、蛋白分泌表达载体和应用
US9963401B2 (en) 2008-12-10 2018-05-08 Reg Synthetic Fuels, Llc Even carbon number paraffin composition and method of manufacturing same
WO2018138316A1 (fr) * 2017-01-27 2018-08-02 Abera Bioscience Ab Nouvelles compositions, procédés et utilisations
WO2020018705A1 (fr) 2018-07-17 2020-01-23 Yale University Méthodes de traitement du cancer à l'aide d'un virus chimère chikungunya-vsv

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CA2793424A1 (fr) * 2010-03-18 2011-09-22 Cornell University Preparation d'anticorps correctement plies utilisant la presentation sur la membrane interieure d'intermediaires de translocation twin-arginine
US11795579B2 (en) 2017-12-11 2023-10-24 Abalone Bio, Inc. Yeast display of proteins in the periplasmic space
WO2020030954A1 (fr) 2018-08-09 2020-02-13 Integrative Medicine Clinic, Sia Protéines sanp de type théragnostique conjuguées à des peptides de ciblage de l'intégrine et de la pmsa et thérapie du cancer de la prostate
WO2024005668A1 (fr) * 2022-06-28 2024-01-04 Андрей Николаевич ВОЛОГОДСКИЙ Procédé de production d'une particule de type virale de bactériophage

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US20030219870A1 (en) * 2002-03-23 2003-11-27 George Georgiou Secretion of proteins with multiple disulfide bonds in bacteria and uses thereof

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Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8987173B2 (en) 2005-08-01 2015-03-24 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
US20080287315A1 (en) * 2005-08-01 2008-11-20 Cornell University Compositions & methods for monitoring and altering protein folding and solubility
US20090220952A1 (en) * 2005-08-22 2009-09-03 Cornell Research Foundation, Inc. Compositions And Methods For Analyzing Protein Interactions
US9150850B2 (en) * 2005-08-22 2015-10-06 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
US20090249101A1 (en) * 2006-09-11 2009-10-01 Apple Inc. Method and system for controlling power provided to an accessory
US20100144546A1 (en) * 2007-01-12 2010-06-10 Cornell University Genetic selection for protein folding and solubility in the bacterial periplasm
US8722584B2 (en) 2007-01-12 2014-05-13 Cornell University Genetic selection for protein folding and solubility in the bacterial periplasm
US8575409B2 (en) 2007-12-20 2013-11-05 Syntroleum Corporation Method for the removal of phosphorus
US9133080B2 (en) 2008-06-04 2015-09-15 Reg Synthetic Fuels, Llc Biorenewable naphtha
US9061951B2 (en) 2008-06-04 2015-06-23 Reg Synthetic Fuels, Llc Biorenewable naphtha composition
US8558042B2 (en) 2008-06-04 2013-10-15 Syntroleum Corporation Biorenewable naphtha
US11097994B2 (en) 2008-12-10 2021-08-24 Reg Synthetic Fuels, Llc Even carbon number paraffin composition and method of manufacturing same
US11623899B2 (en) 2008-12-10 2023-04-11 Reg Synthetic Fuels, Llc Even carbon number paraffin composition and method of manufacturing same
US9963401B2 (en) 2008-12-10 2018-05-08 Reg Synthetic Fuels, Llc Even carbon number paraffin composition and method of manufacturing same
US10717687B2 (en) 2008-12-10 2020-07-21 Reg Synthetic Fuels, Llc Even carbon number paraffin composition and method of manufacturing same
US8481297B2 (en) 2009-01-08 2013-07-09 Yale University Compositions and methods of use of an oncolytic vesicular stomatitis virus
WO2010080909A1 (fr) 2009-01-08 2010-07-15 Yale University Compositions et procédés d'utilisation de virus de la stomatite vésiculaire à action oncolytique
US20100172877A1 (en) * 2009-01-08 2010-07-08 Yale University Compositions and methods of use of an oncolytic vesicular stomatitis virus
WO2011032003A1 (fr) 2009-09-10 2011-03-17 Yale University Immunisation pour réduire la neurotoxicité pendant un traitement avec des virus cytolytiques
WO2011056993A1 (fr) 2009-11-04 2011-05-12 Yale University Compositions et procédés destinés à traiter le cancer par des virus oncolytiques atténués
US8536390B2 (en) 2010-03-18 2013-09-17 Syntroleum Corporation, A Delaware Corporation Profitable method for carbon capture and storage
US10078085B2 (en) * 2012-08-22 2018-09-18 Mogam Biothechnology Institute Screening and engineering method of super-stable immunoglobulin variable domains and their uses
US20160003844A1 (en) * 2012-08-22 2016-01-07 Mogam Biotechnology Research Institute Screening and engineering method of super-stable immunoglobulin variable domains and their uses
US9523041B2 (en) 2013-03-13 2016-12-20 Reg Synthetic Fuels, Llc Reducing pressure drop buildup in bio-oil hydroprocessing reactors
US9328303B2 (en) 2013-03-13 2016-05-03 Reg Synthetic Fuels, Llc Reducing pressure drop buildup in bio-oil hydroprocessing reactors
US8969259B2 (en) 2013-04-05 2015-03-03 Reg Synthetic Fuels, Llc Bio-based synthetic fluids
US11186785B2 (en) 2013-04-05 2021-11-30 Reg Synthetic Fuels, Llc Bio-based synthetic fluids
US10011783B2 (en) 2013-04-05 2018-07-03 Reg Synthetic Fuels, Llc Bio-based synthetic fluids
US10821143B2 (en) 2013-11-22 2020-11-03 Yale University Chimeric VSV virus compositions and methods of use thereof for treatment of cancer
US10179154B2 (en) 2013-11-22 2019-01-15 Yale University Chimeric VSV virus compositions and methods of use thereof for treatment of cancer
WO2015077714A1 (fr) 2013-11-22 2015-05-28 Yale University Compositions de virus vsv chimérique et procédés pour les utiliser pour le traitement du cancer
WO2016020661A1 (fr) * 2014-08-07 2016-02-11 The University Of Sussex Maladie d'alzheimer
JP2017523793A (ja) * 2014-08-07 2017-08-24 ザ ユニバーシティー オブ サセックス アルツハイマー病
CN106573965A (zh) * 2014-08-07 2017-04-19 萨塞克斯大学 阿尔茨海默病
CN106589067A (zh) * 2016-12-21 2017-04-26 生工生物工程（上海）股份有限公司 一种信号肽及其编码基因、蛋白分泌表达载体和应用
WO2018138316A1 (fr) * 2017-01-27 2018-08-02 Abera Bioscience Ab Nouvelles compositions, procédés et utilisations
US11124555B2 (en) 2017-01-27 2021-09-21 Abera Bioscience Ab Fusion polypeptides comprising one or more inclusion body tags, methods and uses
WO2020018705A1 (fr) 2018-07-17 2020-01-23 Yale University Méthodes de traitement du cancer à l'aide d'un virus chimère chikungunya-vsv

Also Published As

Publication number Publication date
US20080287315A1 (en) 2008-11-20
EP2418280A1 (fr) 2012-02-15
WO2007016591A3 (fr) 2008-10-02
CA2617792A1 (fr) 2007-02-08
AU2006275415B2 (en) 2011-07-21
US8987173B2 (en) 2015-03-24
AU2006275415A1 (en) 2007-02-08
EP2418280B1 (fr) 2014-12-10
EP1915390A2 (fr) 2008-04-30
EP1915390B1 (fr) 2014-01-15
WO2007016591A2 (fr) 2007-02-08
EP1915390A4 (fr) 2009-06-03

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