US20060247574A1 - Introducer for a medication infusion set - Google Patents
Introducer for a medication infusion set Download PDFInfo
- Publication number
- US20060247574A1 US20060247574A1 US11/453,484 US45348406A US2006247574A1 US 20060247574 A1 US20060247574 A1 US 20060247574A1 US 45348406 A US45348406 A US 45348406A US 2006247574 A1 US2006247574 A1 US 2006247574A1
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- US
- United States
- Prior art keywords
- introducer
- cannula
- cannula housing
- needle
- connector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- SZFIDNGPMREKGO-VWNGVKENSA-N C=C1/C2=C\C3=CC(C4)=C3/C4=C\C=C/NC1C2 Chemical compound C=C1/C2=C\C3=CC(C4)=C3/C4=C\C=C/NC1C2 SZFIDNGPMREKGO-VWNGVKENSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1587—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/024—Holding devices, e.g. on the body having a clip or clamp system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/0266—Holding devices, e.g. on the body using pads, patches, tapes or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/028—Holding devices, e.g. on the body having a mainly rigid support structure
Definitions
- This invention relates generally to an infusion set for subcutaneous delivery of a selected medication or other fluid to a patient. More particularly, this invention relates to an improved infusion set having a cannula housing and a connector for connecting the cannula housing to a delivery device.
- Infusion sets are typically used for delivering a selected medication or other fluid to a patient.
- Infusion sets may include a cannula, which may be relatively soft and flexible.
- the cannula provides a transcutaneous passageway to administer a medication or other fluid to a subcutaneous site on a patient.
- the cannula generally attached to a cannula housing, which may be placed on the skin of the patient when the cannula is inserted.
- a connector attaches to the cannula housing to connect the cannula to the fluid delivery system.
- the fluid delivery system is generally placed in fluid communication with the connector by way of a length of infusion tubing. Examples of fluid delivery systems are shown in U.S. Pat. Nos. 4,562,751, 4,685,903, 5,080,653, 5,097,122, which are herein incorporated by reference.
- Infusion sets of the type described above are generally used to deliver medication, such as insulin, to a patient over an extended period of time.
- the infusion sets usually are adapted to rest on the skin of the patient.
- the cannula housing may remain on the patient's skin for several days, and the patient may disconnect the connector when performing certain activities, like showering. Because a patient changes infusion sets fairly frequently, it is beneficial to have an infusion set that is easy to insert, easy to connect properly, and easy to remove and dispose of.
- the infusion set comprises a cannula housing with a cannula and a needle holder to be connected to the cannula housing.
- the cannula housing includes two guide openings and two locking openings with shoulders for engaging barbs on locking pins of the needle holder.
- the needle holder includes guide pins that co-operate with the guide openings on the cannula housing. The needle on the needle holder is guided by the guide pins into the cannula housing so that the needle penetrates a membrane at the inlet of a fluid passageway of the cannula housing.
- the fluid passageway is in fluid communication with the cannula.
- the fluid may flow through the connector into the cannula housing and then into the patient.
- the guide pins must be guided carefully into the guide openings, as the guide openings surround the pins on all four sides when the cannula housing and needle holder are guided together.
- the infusion set comprises a cannula housing with a cylindrical extension and a needle holder with a guide sleeve that closely slides over the cylindrical extension.
- the connection must be done carefully, because the cylindrical extension fits closely into the guide sleeve.
- the guide sleeve surrounds a connecting needle that is guided into the passageway of the cylindrical extension.
- the passageway in the cylindrical extension is in fluid communication with the cannula and has a septum at its inlet that is pierced by the connecting needle. Once the septum is pierced, fluid can flow from an infusion device through the needle holder into the cannula housing and then into the patient.
- an infusion set for use in delivering fluid through a cannula to a selected subcutaneous infusion site on a patient.
- the fluid is generally a medication, for example, insulin.
- the cannula is a soft and flexible cannula and is supported by a cannula housing.
- the cannula housing also includes a fluid passageway in fluid communication with the cannula. At one end of the fluid passageway is a self-sealing septum.
- the fluid passageway is surrounded by a projection on the cannula housing that includes one or more rail-like extensions acting as connection guides.
- the rail-like extensions may be substantially triangular or otherwise suitably shaped to act as guides.
- the cannula housing also includes a base that rests upon a patient's skin when the cannula is inserted into the skin.
- the infusion set also includes a connector that connects the cannula housing to fluid tubing that allows fluid to flow from a fluid source, which may be a fluid delivery system, such as an infusion pump, through the connector to the cannula housing and through the cannula into the patient.
- the connector includes a connecting needle that is mounted thereon to pierce the self-sealing septum on the cannula housing to allow flow of fluid through the needle into the fluid passageway.
- the connecting needle is in fluid communication with the fluid tubing.
- the connector also includes one or more guide arms that slide over the rail-like extensions to guide the needle into the self-sealing septum.
- the connector includes one or more locking arms, with barbs at the end, to connect with one or more recesses that are provided in the cannula housing. Once the barbs are pushed into the recesses, the connector is essentially locked in place with respect to the cannula housing.
- the connector is preferably reversible so that it may be connected to the cannula housing regardless of which side is up.
- the cannula housing is inserted into the skin using an introducer.
- the introducer has the same guide arms and locking arms as the connector. It includes an introducing needle that passes through the self-sealing septum and fluid passageway of the cannula housing and into the cannula. When connected to the cannula housing, the tip of the introducing needle is outside the cannula.
- a method of delivery of a fluid comprising positioning a cannula housing according to the invention at an infusion site on a patient and engaging the cannula housing with a connector according to the invention.
- the positioning of the cannula housing may include using an introducer according to the invention to pierce the skin of the patient, and removing the introducer from the cannula housing once the cannula housing is positioned on the infusion site.
- FIG. 1 is a perspective view of a cannula housing and connector in connected form in accordance with an embodiment of the invention
- FIG. 1A is a top view of a cannula housing and connector in connected form in accordance with an embodiment of the invention.
- FIG. 2 is perspective view of a cannula housing, connector, introducer, and internal components in accordance with an embodiment of the invention in an exploded view.
- FIG. 3 is a perspective view of a cannula housing in accordance with an embodiment of the invention.
- FIG. 4 is a perspective view of a connector in accordance with an embodiment of the invention.
- FIG. 5 is a perspective view of an introducer in accordance with an embodiment of the invention.
- FIG. 6 is a horizontal sectional view of a cannula housing and connector in connected form in accordance with an embodiment of the invention.
- FIG. 7 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention.
- FIG. 8 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention.
- FIG. 9 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention.
- FIG. 10 is a perspective view of a cannula housing and connector in separated form in accordance with an embodiment of the invention.
- FIG. 11 is a top and a bottom perspective view of a cannula housing and connector in separated form in accordance with an embodiment of the invention.
- FIG. 12 is a top perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention.
- FIG. 13 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention.
- FIG. 14 is a top perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention.
- the infusion set comprises a cannula housing 100 and a connector 120 .
- the cannula housing 100 carries a soft and flexible cannula 200 .
- the cannula 200 may be tapered at the end. Any flexible tubing may be used for the cannula, provided that is biocompatible and insulin compatible.
- the cannula 200 may be composed of polytetrafluoroethylene (PTFE) or fluorinated ethylene propylene (FEP).
- PTFE polytetrafluoroethylene
- FEP fluorinated ethylene propylene
- the cannula housing 100 has a base 220 that rests upon the patient's skin when the cannula 200 is inserted into the patient.
- the base 220 may be attached to the patient's skin, for example by an adhesive patch.
- a projection 240 of the cannula housing 100 surrounds a fluid passageway (not shown) that is in fluid communication with the cannula 200 .
- a septum 295 At the end of the fluid passageway opposite the cannula is a septum 295 .
- This may be a self-sealing septum, for example a substantially barrel-shaped, such as a beer-barrel shaped, self-sealing septum.
- the septum may also be substantially shaped like a disc or a ball, or any other preferable shape.
- the projection 240 is generally at least partially attached along its length to the base 220 . However, the projection 240 may be entirely separate from the base 220 along its length, allowing a space between the projection 240 and the base 220 . The end of the projection 240 opposite the end with the septum 295 would still be attached to remainder of the cannula housing 100 , such that the cannula housing 100 is still only one integral piece.
- the base 220 may also have a groove 260 cut into it to allow for a higher projection without the need for the entire cannula housing 100 to be taller.
- the projection 240 may have a relatively flat top, which can also reduce the height of the cannula housing 100 and of the infusion set and can reduce the overall volume of the infusion set. When the infusion set is thinner, it can have a lower profile and be less noticeable.
- the two sides of the projection 240 on the cannula housing 100 are rail-like extensions or guide rails 242 and 244 .
- These guide rails 242 and 244 may be substantially triangular, as shown, but they may be shaped in any other configuration that allows for guiding of the connector 120 onto the cannula housing 100 .
- they could be rectangular or peg-shaped.
- At the side of the cannula housing 100 near the cannula 200 there are two recesses 270 and 272 formed to receive barbs that are on locking arms of the connector.
- These guide rails are visible to the user, making the infusion set easier to connect. Additionally, the base of the cannula housing assists in guiding the needle, acting as a bottom boundary for a connector.
- the cannula is preferably angled so that the cannula is inserted into the skin at an angle.
- the fluid passageway and connector fluid passageway may each be similarly angled. If both are angled to match the cannula, the passage of fluid will be one straight line from the point at which the fluid enters the connector until the end of the cannula, where the fluid enters the patient's body.
- the connector 120 connects the cannula housing 100 to fluid tubing 300 , which allows fluid to flow from a fluid source, which may be a fluid delivery system, such as an infusion pump, to the connector 120 .
- the connector 120 includes a connecting needle 320 , which is in fluid communication with the fluid tubing 300 .
- a connector fluid passageway allows the connecting needle 320 to be in fluid communication with the fluid tubing 300 .
- the connector 120 has two locking arms 340 and 342 , with barbs 341 and 343 on each that are received by the recesses 270 and 272 on the cannula housing 100 .
- the locking arms 340 and 342 may be grips on one or more edges of the locking arms 340 and 342 for facilitating grasping by the user.
- the connector 120 When the barbs 341 and 343 are engaged with the recesses 270 and 272 , the connector 120 is essentially locked into the cannula housing 100 .
- the user pushes the locking arms 340 and 342 toward each other and releases the barbs 341 and 343 from the recesses 270 and 272 .
- the locking arms 340 and 342 may be formed as levers, which would allow the ends of the locking arms to release outwardly when the user pressed on the ends opposite the barbs.
- the locking arms may have alternative locking structures to barbs, such as clips or other connecting pieces.
- the guide arms 350 and 352 extend alongside and past the needle 320 . Because the guide arms 350 and 352 extend past the needle 320 , it is difficult for the user to be injured by, or to injure, the needle 320 when the connector 120 is separated from the cannula housing 120 .
- the guide arms 350 and 352 have indentations 351 and 353 that match the guide rails 242 and 244 of the projection 240 of the connector 120 . For example, if the guide rails 242 and 244 are triangular in shape, the guide arms 350 and 352 will have triangular indentations.
- the guide arms 350 and 352 slide along the projection 240 , guiding the needle 320 into the fluid passageway of the cannula housing 100 .
- the connector is preferably symmetrical, so that it is reversible and may be placed into the connector with either of its top or bottom facing upward. If the connector is symmetrical, the patient does not have to worry about which way to place the connector. This will allow for quicker and easier connection.
- the cannula housing may be adhered to the patient's skin by an adhesive.
- the adhesive may be on a patch that is attached to the base of the cannula housing.
- the adhesive is covered with a one or more piece liner 160 (or 165 in FIG. 1A ) that the patient removes to release the adhesive side.
- the liner 160 protects the adhesive from being removed or from attaching to anything else until the patient wishes to use the infusion set.
- the liner can also keep the adhesive layer relatively sterile.
- the adhesive may be on a flat patch that is attached to the base. Alternatively, the adhesive may be folded, as shown in FIG. 1A .
- the patient removes a small liner piece from the unfolded portion of the patch.
- the patient then inserts the cannula into the skin.
- the user pulls the liner off of the folded portion of the patch, allowing it to lie flat on the user's skin.
- the patch may be colored, patterned, or a combination of both.
- the small liner piece from the unfolded portion may have a color and/or pattern that is different from the color and/or pattern on the folded portion to more easily differentiate between the two liners.
- an introducer may be used to insert the cannula into the patient.
- the introducer 140 has guide arms 450 and 452 and locking arms 440 and 442 that are shaped the same as those on the connector 120 .
- the introducer needle 400 is much longer than the needle on the connector.
- the introducer needle 400 is long enough that when the introducer 140 is connected to the cannula housing 100 , the tip of the introducer needle 400 extends beyond the cannula 200 .
- the introducer needle 400 may be affixed to the introducer 140 by a UV or other type of adhesive, by welding, by a molding process, or by any other suitable process.
- the user grips the joined introducer 140 and cannula housing 100 and inserts the tip of the introducer needle 400 into the patient.
- the introducer needle 400 and cannula 200 are pushed into the patient, so that the cannula 200 is almost entirely under the skin of the patient.
- the cannula housing 100 is preferably affixed to the patient's outer skin, and the introducer 140 is unlocked and removed from the cannula housing 100 .
- the connector 120 can then be inserted and locked into the cannula housing 100 so that fluid may be infused into the patient.
- rubber grips may be overmolded onto the grips of the introducer and/or the connector to improve ability to grasp the introducer and/or connector.
- rubber overmold may be added to the cannula housing 100 to improve the user's ability to grasp the part during removal of the introducer 140 or connector 120 .
- the cannula housing 100 can be packaged connected to the introducer.
- a needle guard may cover the introducer needle, which extends beyond the cannula.
- the needle guard may be a small plastic tube that covers the needle and some or all of the cannula. If a small plastic tube is used as a needle guard, it may be colored so that it is easily visible. Thus, the patient easily would be able to see if the needle guard is in place.
- the small plastic tube may have only holes at each end of the tube. Alternatively, it may be slit down the side for ease of removal and replacement.
- a slit guard may reduce damage to the cannula 200 caused by attempting to slide the small plastic tube onto the needle and cannula.
- a larger needle cover may also be used. The larger needle cover may connect or snap to the cannula housing. It may also act as a cover for the introducer after insertion of the cannula, when the introducer is removed from the cannula housing.
- the cannula housing may be made out of a plastic, such as an acrylic or polypropylene or polycarbonate.
- a polycarbonate cannula housing may be transparent, so that the patient can see whether any bubbles are present in the fluid passageway.
- the connector may also be made out of a plastic, such as an acrylic or polypropylene or polycarbonate.
- a polycarbonate connector may be transparent, so that the patient can see whether any bubbles are present in the connector fluid passageway.
- the plastics used for the cannula housing and the connector should be compatible with the medication or fluid selected for delivery through these parts and should pass the required biological tests for skin contact.
- the patch or infusion set itself may be time-sensitive, to indicate to the patient when it is time to remove the infusion set.
- a time-sensitive indicator may be chemical, mechanical, or electrical.
- the patch itself, a portion of the patch, the infusion set, or a portion of the infusion set may contain an ink that changes color or appearance with passage of time.
- An infusion set is typically used for a minimum of 3 days, but may be adapted to be used for any predetermined period of time.
- the time-sensitive indicator may be designed to be used for any predetermined period of time.
- a different colored patch may be used for a different day of the week, meaning the first and/or last day for the infusion set, so that the user will easily know when to change the infusion set. For example, if the color red means the first day for the set is Monday and the last day is set for Wednesday, the user will know to insert the infusion set on Monday and to remove it on Wednesday.
- Graphics and other designs may also be printed on the patches.
- FIG. 6 is a cutaway view of the infusion set comprising the cannula housing 100 and the connector 120 .
- the connecting needle 320 has pierced the substantially beer-barrel shaped septum 295 to allow flow from the fluid tubing 300 into the fluid passageway 380 .
- a washer 290 At the end of the cannula housing 100 , past the beer-barrel shaped septum 295 there may be a washer 290 , which can assist in holding the beer-barrel shaped septum 295 in place and provide compression to the septum to create a seal.
- the washer 290 may be made of suitable materials, for example metal or plastic.
- the washer 390 may be welded to the connector to retain the septum 295 .
- a needle guide 395 may be used to align the needle with the fluid passageway 380 .
- the needle guide 395 may be a metal guide or a plastic guide.
- one or more sealing points may be used.
- an injector tool may be used.
- Injector tools may be of the type described in PCT Publication No. WO 02/100457 A2, entitled “Insertion Device for an Insertion Set and Method of Using Same,” published Dec. 19, 2002, which is herein incorporated by reference. Injector tools are useful for patients who are reluctant or hesitant to pierce their own skin with a medical needle.
- the injector tool is designed to place the needle through the skin at a selected insertion angle and with a controlled force and speed of insertion to ensure proper placement with minimal discomfort.
- infusion sets comprising cannula housings and connectors, and the corresponding introducers, are described below. Because the structure of the portion of the introducer that mates with the cannula housing is the same as the portion of the connector that mates with the cannula housing, each embodiment is described with respect to the introducer and cannula housing or with respect to the connector and cannula housing. It is intended that the connector and/or introducer not described has the same mating structure as the element that is described.
- the introducer 140 does not have guide arms that are separate from locking arms. Instead, the locking arms 640 and 642 each include barbs ( 641 and 643 ) and guide rails ( 644 and 645 ). The guide rails 644 and 645 slide into recesses 650 and 652 on the cannula housing 100 .
- the introducer 140 does not have guide arms.
- the locking arms 740 and 742 with barbs 741 and 743 are as described with respect to FIGS. 1-4 .
- the introducer 140 includes a guide sheath 750 that closely slides over the projection 760 on the cannula housing 120 that surrounds the fluid passageway (not shown).
- the guide sheath 750 is also guided by two guide rails 772 and 774 that contain indentations matching the exterior of the guide sheath 750 .
- the guide sheath closely fits in between the projection 760 and the guide rails 772 and 774 to guide the introducer 140 and introducer needle (not shown) into the cannula housing 100 .
- the introducer 140 does not have guide arms.
- the locking arms 840 and 842 with barbs 841 and 843 are as described with respect to FIGS. 1-4 .
- the introducer 140 has a dove tail 850 that mates with a cut-out 860 to guide the introducer 140 and introducer needle (not shown) into the cannula housing 100 .
- the connector 120 does not have guide arms.
- the locking arms 940 and 942 with barbs 941 and 943 are as described with respect to FIGS. 1-4 .
- the connector 120 also includes a guide pin 950 that can mate with one of two guide openings 960 , 962 on the cannula housing 100 .
- the cannula housing 100 and connector 120 are preferably symmetrical, aside from the one guide pin 950 , so that the user may insert the connector 120 into the cannula housing 100 regardless of which side is up.
- whether the one guide pin 950 will slide into a particular guide opening, 960 or 962 is dependent upon which way the connector 120 is placed with respect to the cannula housing 100 . But it will be equally easy to slide the connector 120 into the cannula housing 100 in each placement.
- the connector 120 does not have guide arms.
- the locking arms 1040 and 1042 each include barbs ( 1041 and 1043 ) and guide rails ( 1044 and 1045 ).
- the guide rails 1044 and 1045 slide into recesses 1050 and 1052 on the cannula housing 100 .
- this embodiment may include underside rails 1053 and 1054 on the cannula housing 100 , which slide alongside matching underside guide features 1055 and 1056 on the locking arms 1040 and 1042 .
- the connector 120 is guided into the cannula housing 100 by both combinations of the guide rails 1044 , 1045 and recesses 1050 , 1052 and the underside rails 1053 , 1054 and underside guide features 1055 , 1056 .
- the connector 120 does not have guide arms.
- the locking arms ( 1140 and 1142 , 1240 and 1242 , and 1340 and 1342 ) with barbs ( 1141 and 1143 , 1241 and 1243 , and 1341 and 1343 ) are as described with respect to FIGS. 1-4 .
- the connector 120 includes a partial guide sheath which may be a half box sheath 1150 , an incomplete box sheath 1250 , or an incomplete oval sheath 1350 .
- the guide sheath ( 1150 , 1250 , or 1350 ) closely slides over the projection ( 1160 , 1260 , or 1360 ) on the cannula housing 120 that surrounds the fluid passageway (not shown).
- the guide sheath ( 1150 , 1250 , or 1350 ) is also guided by two guide rails ( 1172 and 1174 , 1272 and 1274 , and 1372 and 1374 ) that mate with the exterior of the guide sheath ( 1150 , 1250 , or 1350 ).
- the guide sheath closely fits in between the projection and the guide rails to guide the connector 120 and connector needle (not shown) into the cannula housing 100 .
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Abstract
An introducer is provided for introducing a cannula for subcutaneous administration of fluid into a patient. The fluid is generally a medication, for example, insulin. The cannula is in fluid communication with a fluid passageway surrounded by a projection on the cannula housing that includes one or more rail-like extensions acting as connection guides. The introducer includes an introducer needle and one or more guide arms that slide over the rail-like extensions to guide the needle into the self-sealing septum. The introducer includes one or more locking arms, with barbs at the end, to connect with one or more recesses that are provided in the cannula housing.
Description
- This is a divisional application, which claims priority from U.S. patent application Ser. No. 11/003,225, filed Dec. 3, 2004, which is herein incorporated by reference.
- 1. Field of the Invention
- This invention relates generally to an infusion set for subcutaneous delivery of a selected medication or other fluid to a patient. More particularly, this invention relates to an improved infusion set having a cannula housing and a connector for connecting the cannula housing to a delivery device.
- 2. Description of Related Art
- Infusion sets are typically used for delivering a selected medication or other fluid to a patient. Infusion sets may include a cannula, which may be relatively soft and flexible. The cannula provides a transcutaneous passageway to administer a medication or other fluid to a subcutaneous site on a patient. The cannula generally attached to a cannula housing, which may be placed on the skin of the patient when the cannula is inserted. A connector attaches to the cannula housing to connect the cannula to the fluid delivery system. The fluid delivery system is generally placed in fluid communication with the connector by way of a length of infusion tubing. Examples of fluid delivery systems are shown in U.S. Pat. Nos. 4,562,751, 4,685,903, 5,080,653, 5,097,122, which are herein incorporated by reference.
- Infusion sets of the type described above are generally used to deliver medication, such as insulin, to a patient over an extended period of time. The infusion sets usually are adapted to rest on the skin of the patient. The cannula housing may remain on the patient's skin for several days, and the patient may disconnect the connector when performing certain activities, like showering. Because a patient changes infusion sets fairly frequently, it is beneficial to have an infusion set that is easy to insert, easy to connect properly, and easy to remove and dispose of.
- An infusion set of the above type is described in U.S. Pat. No. 5,522,803. The infusion set comprises a cannula housing with a cannula and a needle holder to be connected to the cannula housing. The cannula housing includes two guide openings and two locking openings with shoulders for engaging barbs on locking pins of the needle holder. The needle holder includes guide pins that co-operate with the guide openings on the cannula housing. The needle on the needle holder is guided by the guide pins into the cannula housing so that the needle penetrates a membrane at the inlet of a fluid passageway of the cannula housing. The fluid passageway is in fluid communication with the cannula. Thus, when the needle penetrates the membrane, the fluid may flow through the connector into the cannula housing and then into the patient. The guide pins must be guided carefully into the guide openings, as the guide openings surround the pins on all four sides when the cannula housing and needle holder are guided together.
- Another infusion set of the above type is described in U.S. Pat. No. 6,302,866. The infusion set comprises a cannula housing with a cylindrical extension and a needle holder with a guide sleeve that closely slides over the cylindrical extension. The connection must be done carefully, because the cylindrical extension fits closely into the guide sleeve. The guide sleeve surrounds a connecting needle that is guided into the passageway of the cylindrical extension. The passageway in the cylindrical extension is in fluid communication with the cannula and has a septum at its inlet that is pierced by the connecting needle. Once the septum is pierced, fluid can flow from an infusion device through the needle holder into the cannula housing and then into the patient.
- In accordance with the invention, an infusion set is provided for use in delivering fluid through a cannula to a selected subcutaneous infusion site on a patient. The fluid is generally a medication, for example, insulin. The cannula is a soft and flexible cannula and is supported by a cannula housing. The cannula housing also includes a fluid passageway in fluid communication with the cannula. At one end of the fluid passageway is a self-sealing septum. The fluid passageway is surrounded by a projection on the cannula housing that includes one or more rail-like extensions acting as connection guides. The rail-like extensions may be substantially triangular or otherwise suitably shaped to act as guides. The cannula housing also includes a base that rests upon a patient's skin when the cannula is inserted into the skin.
- The infusion set also includes a connector that connects the cannula housing to fluid tubing that allows fluid to flow from a fluid source, which may be a fluid delivery system, such as an infusion pump, through the connector to the cannula housing and through the cannula into the patient. The connector includes a connecting needle that is mounted thereon to pierce the self-sealing septum on the cannula housing to allow flow of fluid through the needle into the fluid passageway. The connecting needle is in fluid communication with the fluid tubing. The connector also includes one or more guide arms that slide over the rail-like extensions to guide the needle into the self-sealing septum. The connector includes one or more locking arms, with barbs at the end, to connect with one or more recesses that are provided in the cannula housing. Once the barbs are pushed into the recesses, the connector is essentially locked in place with respect to the cannula housing. The connector is preferably reversible so that it may be connected to the cannula housing regardless of which side is up.
- The cannula housing is inserted into the skin using an introducer. The introducer has the same guide arms and locking arms as the connector. It includes an introducing needle that passes through the self-sealing septum and fluid passageway of the cannula housing and into the cannula. When connected to the cannula housing, the tip of the introducing needle is outside the cannula.
- A method of delivery of a fluid is provided comprising positioning a cannula housing according to the invention at an infusion site on a patient and engaging the cannula housing with a connector according to the invention. The positioning of the cannula housing may include using an introducer according to the invention to pierce the skin of the patient, and removing the introducer from the cannula housing once the cannula housing is positioned on the infusion site.
- A detailed description of embodiments of the invention will be made with reference to the accompanying drawings, wherein like numerals designate corresponding parts in the figures.
-
FIG. 1 is a perspective view of a cannula housing and connector in connected form in accordance with an embodiment of the invention -
FIG. 1A is a top view of a cannula housing and connector in connected form in accordance with an embodiment of the invention. -
FIG. 2 is perspective view of a cannula housing, connector, introducer, and internal components in accordance with an embodiment of the invention in an exploded view. -
FIG. 3 is a perspective view of a cannula housing in accordance with an embodiment of the invention. -
FIG. 4 is a perspective view of a connector in accordance with an embodiment of the invention. -
FIG. 5 is a perspective view of an introducer in accordance with an embodiment of the invention. -
FIG. 6 is a horizontal sectional view of a cannula housing and connector in connected form in accordance with an embodiment of the invention. -
FIG. 7 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention. -
FIG. 8 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention. -
FIG. 9 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention. -
FIG. 10 is a perspective view of a cannula housing and connector in separated form in accordance with an embodiment of the invention. -
FIG. 11 is a top and a bottom perspective view of a cannula housing and connector in separated form in accordance with an embodiment of the invention. -
FIG. 12 is a top perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention. -
FIG. 13 is a perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention. -
FIG. 14 is a top perspective view of a cannula housing and introducer in separated form in accordance with an embodiment of the invention. - In the following description, reference is made to the accompanying drawings which form a part hereof and which illustrate several embodiments of the present invention. It is understood that other embodiments may be utilized and structural and operational changes may be made without departing from the scope of the present invention.
- As shown in
FIGS. 1-3 , the infusion set comprises acannula housing 100 and aconnector 120. Thecannula housing 100 carries a soft andflexible cannula 200. Thecannula 200 may be tapered at the end. Any flexible tubing may be used for the cannula, provided that is biocompatible and insulin compatible. For example, but without limitation, thecannula 200 may be composed of polytetrafluoroethylene (PTFE) or fluorinated ethylene propylene (FEP). Thecannula housing 100 has a base 220 that rests upon the patient's skin when thecannula 200 is inserted into the patient. The base 220 may be attached to the patient's skin, for example by an adhesive patch. Although thebase 220 is shown as at least partially circular in nature, it may be square, rectangular or any other shape that is desired. Aprojection 240 of thecannula housing 100 surrounds a fluid passageway (not shown) that is in fluid communication with thecannula 200. At the end of the fluid passageway opposite the cannula is aseptum 295. This may be a self-sealing septum, for example a substantially barrel-shaped, such as a beer-barrel shaped, self-sealing septum. The septum may also be substantially shaped like a disc or a ball, or any other preferable shape. - The
projection 240 is generally at least partially attached along its length to thebase 220. However, theprojection 240 may be entirely separate from thebase 220 along its length, allowing a space between theprojection 240 and thebase 220. The end of theprojection 240 opposite the end with theseptum 295 would still be attached to remainder of thecannula housing 100, such that thecannula housing 100 is still only one integral piece. The base 220 may also have agroove 260 cut into it to allow for a higher projection without the need for theentire cannula housing 100 to be taller. Theprojection 240 may have a relatively flat top, which can also reduce the height of thecannula housing 100 and of the infusion set and can reduce the overall volume of the infusion set. When the infusion set is thinner, it can have a lower profile and be less noticeable. - The two sides of the
projection 240 on thecannula housing 100 are rail-like extensions orguide rails guide rails connector 120 onto thecannula housing 100. For example, they could be rectangular or peg-shaped. At the side of thecannula housing 100 near thecannula 200, there are tworecesses - As shown in
FIGS. 1, 2 and 4, theconnector 120 connects thecannula housing 100 tofluid tubing 300, which allows fluid to flow from a fluid source, which may be a fluid delivery system, such as an infusion pump, to theconnector 120. Theconnector 120 includes a connectingneedle 320, which is in fluid communication with thefluid tubing 300. Inside theconnector 120, a connector fluid passageway allows the connectingneedle 320 to be in fluid communication with thefluid tubing 300. Theconnector 120 has two lockingarms barbs recesses cannula housing 100. There may be grips on one or more edges of the lockingarms barbs recesses connector 120 is essentially locked into thecannula housing 100. To disconnect theconnector 120 from thecannula housing 120, the user pushes the lockingarms barbs recesses arms - On either side of the
needle 320 on theconnector 120 are guidearms guide arms needle 320. Because theguide arms needle 320, it is difficult for the user to be injured by, or to injure, theneedle 320 when theconnector 120 is separated from thecannula housing 120. Theguide arms indentations guide rails projection 240 of theconnector 120. For example, if theguide rails guide arms connector 120 to thecannula housing 100, theguide arms projection 240, guiding theneedle 320 into the fluid passageway of thecannula housing 100. - The connector is preferably symmetrical, so that it is reversible and may be placed into the connector with either of its top or bottom facing upward. If the connector is symmetrical, the patient does not have to worry about which way to place the connector. This will allow for quicker and easier connection.
- The cannula housing may be adhered to the patient's skin by an adhesive. The adhesive may be on a patch that is attached to the base of the cannula housing. In one embodiment, as shown in
FIGS. 1, 1A and 2, the adhesive is covered with a one or more piece liner 160 (or 165 inFIG. 1A ) that the patient removes to release the adhesive side. Theliner 160 protects the adhesive from being removed or from attaching to anything else until the patient wishes to use the infusion set. The liner can also keep the adhesive layer relatively sterile. As shown inFIGS. 1 and 2 , the adhesive may be on a flat patch that is attached to the base. Alternatively, the adhesive may be folded, as shown inFIG. 1A . In the folded configuration, the patient removes a small liner piece from the unfolded portion of the patch. The patient then inserts the cannula into the skin. Afterward, the user pulls the liner off of the folded portion of the patch, allowing it to lie flat on the user's skin. In either configuration, the patch may be colored, patterned, or a combination of both. In the folded configuration, the small liner piece from the unfolded portion may have a color and/or pattern that is different from the color and/or pattern on the folded portion to more easily differentiate between the two liners. - To insert the cannula into the patient, an introducer may be used. As shown in
FIGS. 2 and 5 , theintroducer 140 has guidearms arms connector 120. However, theintroducer needle 400 is much longer than the needle on the connector. Theintroducer needle 400 is long enough that when theintroducer 140 is connected to thecannula housing 100, the tip of theintroducer needle 400 extends beyond thecannula 200. Theintroducer needle 400 may be affixed to theintroducer 140 by a UV or other type of adhesive, by welding, by a molding process, or by any other suitable process. To insert thecannula 200 into the patient, the user grips the joinedintroducer 140 andcannula housing 100 and inserts the tip of theintroducer needle 400 into the patient. Theintroducer needle 400 andcannula 200 are pushed into the patient, so that thecannula 200 is almost entirely under the skin of the patient. Thecannula housing 100 is preferably affixed to the patient's outer skin, and theintroducer 140 is unlocked and removed from thecannula housing 100. Theconnector 120 can then be inserted and locked into thecannula housing 100 so that fluid may be infused into the patient. In further embodiments, rubber grips may be overmolded onto the grips of the introducer and/or the connector to improve ability to grasp the introducer and/or connector. In addition, rubber overmold may be added to thecannula housing 100 to improve the user's ability to grasp the part during removal of theintroducer 140 orconnector 120. - The
cannula housing 100 can be packaged connected to the introducer. To protect the patient from injury from the needle, a needle guard may cover the introducer needle, which extends beyond the cannula. The needle guard may be a small plastic tube that covers the needle and some or all of the cannula. If a small plastic tube is used as a needle guard, it may be colored so that it is easily visible. Thus, the patient easily would be able to see if the needle guard is in place. The small plastic tube may have only holes at each end of the tube. Alternatively, it may be slit down the side for ease of removal and replacement. A slit guard may reduce damage to thecannula 200 caused by attempting to slide the small plastic tube onto the needle and cannula. A larger needle cover may also be used. The larger needle cover may connect or snap to the cannula housing. It may also act as a cover for the introducer after insertion of the cannula, when the introducer is removed from the cannula housing. - The cannula housing may be made out of a plastic, such as an acrylic or polypropylene or polycarbonate. A polycarbonate cannula housing may be transparent, so that the patient can see whether any bubbles are present in the fluid passageway. The connector may also be made out of a plastic, such as an acrylic or polypropylene or polycarbonate. As in the cannula housing, a polycarbonate connector may be transparent, so that the patient can see whether any bubbles are present in the connector fluid passageway. The plastics used for the cannula housing and the connector should be compatible with the medication or fluid selected for delivery through these parts and should pass the required biological tests for skin contact.
- The patch or infusion set itself may be time-sensitive, to indicate to the patient when it is time to remove the infusion set. A time-sensitive indicator may be chemical, mechanical, or electrical. The patch itself, a portion of the patch, the infusion set, or a portion of the infusion set may contain an ink that changes color or appearance with passage of time. An infusion set is typically used for a minimum of 3 days, but may be adapted to be used for any predetermined period of time. Similarly, the time-sensitive indicator may be designed to be used for any predetermined period of time. Alternatively, a different colored patch may be used for a different day of the week, meaning the first and/or last day for the infusion set, so that the user will easily know when to change the infusion set. For example, if the color red means the first day for the set is Monday and the last day is set for Wednesday, the user will know to insert the infusion set on Monday and to remove it on Wednesday. Graphics and other designs may also be printed on the patches.
-
FIG. 6 is a cutaway view of the infusion set comprising thecannula housing 100 and theconnector 120. The connectingneedle 320 has pierced the substantially beer-barrel shapedseptum 295 to allow flow from thefluid tubing 300 into thefluid passageway 380. At the end of thecannula housing 100, past the beer-barrel shapedseptum 295 there may be awasher 290, which can assist in holding the beer-barrel shapedseptum 295 in place and provide compression to the septum to create a seal. Thewasher 290 may be made of suitable materials, for example metal or plastic. The washer 390 may be welded to the connector to retain theseptum 295. Aneedle guide 395 may be used to align the needle with thefluid passageway 380. Theneedle guide 395 may be a metal guide or a plastic guide. To seal theneedle guide 395 into thecannula housing 100, one or more sealing points may be used. - To aid in insertion of the cannula, an injector tool may be used. Injector tools may be of the type described in PCT Publication No. WO 02/100457 A2, entitled “Insertion Device for an Insertion Set and Method of Using Same,” published Dec. 19, 2002, which is herein incorporated by reference. Injector tools are useful for patients who are reluctant or hesitant to pierce their own skin with a medical needle. The injector tool is designed to place the needle through the skin at a selected insertion angle and with a controlled force and speed of insertion to ensure proper placement with minimal discomfort.
- Without being limited, several other embodiments of infusion sets comprising cannula housings and connectors, and the corresponding introducers, are described below. Because the structure of the portion of the introducer that mates with the cannula housing is the same as the portion of the connector that mates with the cannula housing, each embodiment is described with respect to the introducer and cannula housing or with respect to the connector and cannula housing. It is intended that the connector and/or introducer not described has the same mating structure as the element that is described.
- As shown in
FIG. 7 , in one embodiment theintroducer 140 does not have guide arms that are separate from locking arms. Instead, the lockingarms recesses cannula housing 100. - As shown in
FIG. 8 , in one embodiment theintroducer 140 does not have guide arms. The lockingarms barbs FIGS. 1-4 . Theintroducer 140 includes aguide sheath 750 that closely slides over the projection 760 on thecannula housing 120 that surrounds the fluid passageway (not shown). Theguide sheath 750 is also guided by twoguide rails guide sheath 750. Thus the guide sheath closely fits in between the projection 760 and theguide rails introducer 140 and introducer needle (not shown) into thecannula housing 100. - As shown in
FIG. 9 , in one embodiment theintroducer 140 does not have guide arms. The lockingarms barbs FIGS. 1-4 . Theintroducer 140 has adove tail 850 that mates with a cut-out 860 to guide theintroducer 140 and introducer needle (not shown) into thecannula housing 100. - As shown in
FIG. 10 , in one embodiment theconnector 120 does not have guide arms. The lockingarms barbs FIGS. 1-4 . Theconnector 120 also includes a guide pin 950 that can mate with one of twoguide openings cannula housing 100. As in other embodiments, thecannula housing 100 andconnector 120 are preferably symmetrical, aside from the one guide pin 950, so that the user may insert theconnector 120 into thecannula housing 100 regardless of which side is up. Thus, whether the one guide pin 950 will slide into a particular guide opening, 960 or 962, is dependent upon which way theconnector 120 is placed with respect to thecannula housing 100. But it will be equally easy to slide theconnector 120 into thecannula housing 100 in each placement. - As shown in
FIG. 11 , in one embodiment theconnector 120 does not have guide arms. Instead, the lockingarms guide rails recesses cannula housing 100. Additionally, this embodiment may includeunderside rails cannula housing 100, which slide alongside matching underside guide features 1055 and 1056 on the lockingarms connector 120 is guided into thecannula housing 100 by both combinations of theguide rails recesses - As shown in
FIGS. 12-14 , in several embodiments, theconnector 120 does not have guide arms. The locking arms (1140 and 1142, 1240 and 1242, and 1340 and 1342) with barbs (1141 and 1143, 1241 and 1243, and 1341 and 1343) are as described with respect toFIGS. 1-4 . Theconnector 120 includes a partial guide sheath which may be ahalf box sheath 1150, anincomplete box sheath 1250, or an incompleteoval sheath 1350. The guide sheath (1150, 1250, or 1350) closely slides over the projection (1160, 1260, or 1360) on thecannula housing 120 that surrounds the fluid passageway (not shown). The guide sheath (1150, 1250, or 1350) is also guided by two guide rails (1172 and 1174, 1272 and 1274, and 1372 and 1374) that mate with the exterior of the guide sheath (1150, 1250, or 1350). Thus the guide sheath closely fits in between the projection and the guide rails to guide theconnector 120 and connector needle (not shown) into thecannula housing 100. - While the description above refers to particular embodiments of the present invention, it will be understood that many modifications may be made without departing from the spirit thereof. The accompanying claims are intended to cover such modifications as would fall within the true scope and spirit of the present invention.
- The presently disclosed embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims, rather than the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Claims (13)
1. An introducer to introduce a cannula for subcutaneous administration of fluid into a patient, the introducer comprising:
an introducer needle;
a first arm having a first groove adapted to slide on a first guide rail of a cannula housing and a second arm having a second groove adapted to slide on a second guide rail of the cannula housing,
wherein the cannula housing includes a cannula mounted thereon and fluid communication with a fluid passageway inside a projection, and wherein the first guide rail and the second guide rail are each on the projection.
2. The introducer of claim 1 , wherein the first groove extends along substantially all of the length of the first arm.
3. The introducer of claim 1 , further comprising a first locking arm, wherein the first locking arm includes a first barb adapted to be received by a first recess in the cannula housing.
4. The introducer of claim 3 , further comprising a second locking arm, wherein the second locking arm includes a second barb adapted to be received by a second recess in the cannula housing.
5. The introducer of claim 3 , wherein the locking arm includes a grip.
6. The introducer of claim 1 , wherein the first guide rail and the second guide rail are each substantially triangular shaped.
7. The introducer of claim 1 , wherein the fluid is insulin.
8. The introducer of claim 1 , wherein the introducer is composed of acrylic.
9. The introducer of claim 1 , wherein the introducer is composed of polypropylene.
10. The introducer of claim 1 , wherein the introducer is composed of polycarbonate.
11. The introducer of claim 1 , further including a needle guard adapted to cover the introducer needle.
12. The introducer of claim 1 , wherein the introducer is reversible.
13. A method of introducing a cannula for subcutaneous administration of fluid into a patient, comprising:
inserting an introducer needle of an introducer and a cannula into a insertion site on a patient, wherein the introducer includes:
the introducer needle; and
a first arm having a first groove adapted to slide on a first guide rail of a cannula housing and a second arm having a second groove adapted to slide on a second guide rail of the cannula housing,
wherein the cannula is mounted on a cannula housing and is in fluid communication with a fluid passageway inside a projection on the cannula housing, and wherein the first guide rail and the second guide rail are each on the projection, and
wherein the introducer is connected to the cannula housing such that the introducer needle extends through the cannula; and
disconnecting the introducer from the cannula housing, whereby the introducer needle is removed from the cannula.
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Also Published As
Publication number | Publication date |
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US8162876B2 (en) | 2012-04-24 |
US20120165736A1 (en) | 2012-06-28 |
US20080045891A1 (en) | 2008-02-21 |
US20140194819A1 (en) | 2014-07-10 |
US7303543B1 (en) | 2007-12-04 |
WO2006062636A1 (en) | 2006-06-15 |
US20120059320A1 (en) | 2012-03-08 |
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