US20060229905A1 - Animal food supplement compositions and methods of use - Google Patents

Animal food supplement compositions and methods of use Download PDF

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US20060229905A1
US20060229905A1 US11/449,424 US44942406A US2006229905A1 US 20060229905 A1 US20060229905 A1 US 20060229905A1 US 44942406 A US44942406 A US 44942406A US 2006229905 A1 US2006229905 A1 US 2006229905A1
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animal
food supplement
psyllium husk
composition
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Gayle Swain
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system

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  • the present invention relates to animal food supplement compositions and methods of using the same, the compositions being particularly useful in relation to, but not limited to, treatment of colic and other gastrointestinal problems in animals.
  • Animal healthcare is an important consideration in many aspects of the economy, such as in food production, research, education (e.g., in zoos) and animal competitions (e.g., horse racing).
  • Productivity, cost control and profitability in these areas of the economy are improved when the health of the animals involved is improved.
  • Efficient and cost-effective animal healthcare is especially important where a substantial investment is required to raise animals to maturity, as is the case with horses.
  • Colic generally refers to malfunction, swelling, infection, or blockage in the gastrointestinal tract of an animal.
  • intestinal detritus refers to the aforementioned ingested sand, soil, and other extraneous materials accumulated in the gastrointestinal tract of an animal.
  • Instances of colic are particularly distressing for the animal and for the owner, because colic is frequently painful to the animal and difficult to identify and treat. Though an owner may try numerous treatments to relieve the animal's symptoms, unfortunately, previously known treatments often prove ineffective and, unfortunately, animals regularly die as a result of colic. For example, approximately one in ten horses with colic die because no effective treatment has been available in the past.
  • the present invention overcomes, at least in part, some of the aforementioned disadvantages of prior art treatments for colic and other gastrointestinal problems in animals.
  • the present invention provides an animal food supplement particularly useful in treating gastrointestinal problems, such as colic, in horses, cattle, swine, chickens, broilers, quail, pheasants, turkeys, ostrich, emus, and other exotic birds.
  • Psyllium husk is the only natural gelatinous and hygroscopic material that is suitable for consumption by both humans and animals, so it is abundantly available.
  • psyllium husk may be provided in dry form for convenience of handling prior to feeding.
  • psyllium husks may be admixed with binding material having low moisture content, and the admixture is formed into pellets, crumbles, mash, or licks.
  • the psyllium husk material Upon consumption by the animal, the psyllium husk material takes up water from the moist environment of the animal's gastrointestinal tract and forms a gelatinous bolus that sweeps through the animal's gastrointestinal tract, clearing intestinal detritus, such as sand, soil, toxins, and microorganisms, which agglomerates with and/or is carried away by the psyllium husk gel.
  • intestinal detritus such as sand, soil, toxins, and microorganisms
  • a first aspect of the present invention includes an animal food supplement composition including psyllium husk.
  • the animal food supplement may further comprise creatine.
  • a second aspect of the present invention includes a pharmaceutical composition
  • a pharmaceutical composition comprising an animal food supplement composition as an active ingredient optionally admixed with a pharmaceutically acceptable carrier, the animal food supplement composition including psyllium husk.
  • a third aspect of the present invention includes a method of using an animal food supplement composition for the preparation of medicaments for the treatment of animal gastrointestinal problems, such as horse colic, wherein the animal food supplement composition includes psyllium husk.
  • a fourth aspect of the present invention includes a packaged animal food supplement composition comprising a substantially hermetic packaging material containing the animal food supplement composition and an atmosphere with a reduced oxygen content in comparison to ambient air.
  • a fifth aspect of the present invention includes a method of using an animal food supplement composition including psyllium husk for reducing the need for antibiotics to be given to an animal.
  • a sixth aspect of the present invention includes a method of using an animal food supplement composition including psyllium husk to increase the content of Bacteroides thetaiotamicron in the gastrointestinal tract of an animal.
  • a seventh aspect of the invention includes a method of using an animal food supplement composition including psyllium husk to decrease the gastrointestinal content of organisms other than Bacteroides thetaiotamicron in an animal.
  • An eighth aspect of the invention includes a method of increasing the rate of growth during a growth period in an animal by providing an animal food supplement composition including psyllium husk to the animal before or during the growth period.
  • a ninth aspect of the invention includes methods of optimizing a feeding regime including an animal food supplement composition comprising psyllium husk, the method comprising monitoring the bacterial content in the feces of an animal.
  • a tenth aspect of the invention includes a method of eradicating rodents comprising distributing in a area where rodents are present a food supplement composition comprising psyllium husk material and at least one binding agent for binding the psyllium husk material in a desired physical form.
  • the present invention advantageously may be incorporated in the ordinary diet of an animal as a treatment for, or preventive measure against, colic and other gastrointestinal problems.
  • An additional advantage of the present invention is that it requires only the use of natural ingredients.
  • FIG. 1 is a graphical depiction of a pellet physical form of the food supplement composition of the invention.
  • FIG. 2 is a graphical depiction of a crumble physical form of the food supplement composition of the invention.
  • FIG. 3 is a graphical depiction of a mash physical form of the food supplement composition of the invention.
  • FIG. 4 is a graphical depiction of a lick physical form of the food supplement composition of the invention.
  • FIG. 5 is a graphical depiction of a specialized package containing the food supplement composition of the invention.
  • the present invention makes beneficial use of the hygroscopic properties of psyllium husks.
  • Psyllium husks swell when they come into contact with water and thus are difficult to handle conveniently when mixed with conventional animal feeds that have a high moisture content, such as molasses and water. Accordingly, it is preferred to provide psyllium husks in dry form for convenience in handling.
  • the psyllium husks Upon consumption by the animal, the psyllium husks take up water from the moist environment of the animal's gastrointestinal tract and form a gelatinous bolus that sweeps through the gastrointestinal tract of the animal, clearing the gastrointestinal tract of intestinal detritus, such as sand, soil, toxins, and microorganisms, which agglomerate with and/or are carried away by the psyllium husk gel.
  • intestinal detritus such as sand, soil, toxins, and microorganisms
  • the present invention provides an animal food supplement that is designed to be palatable to animals for which it is intended, e.g., by using flavors, aromas and textures that appeal to the animal to be treated.
  • flavors, aromas, and textures appropriate for a given subject, i.e., the design of a palatable product, is well within the skill of the ordinary artisan and is, therefore, not discussed further here.
  • the present invention provides an animal food supplement prepared from psyllium husks mixed together with a relatively low moisture content binding agent.
  • the animal food supplement is extruded into pellet form (as depicted in FIG. 1 ) for ease of inclusion into the animal's feed box and to ensure consumption thereof by the animal.
  • the animal food supplement of the invention may be manufactured in a crumble form (as depicted in FIG. 2 ), a mash form (as depicted in FIG. 3 ), or an animal lick form (as depicted in FIG. 4 ).
  • the animal food supplement of the present invention contains from 0 to about 95 percent by weight of psyllium husks in seed, powdered or granulated form, including particulate material comprising stalk, flower and leaf fragments with up to 0 to about 75 percent impurities. It is currently preferred that the food supplement contain about 50 percent psyllium husks. Most preferably according to present beliefs, the food supplement should contain about 30 to 35 percent psyllium husks.
  • the animal food supplement of the present invention may also contain from 0 to about 95 percent grain by-products, including oats, barley, maize, lupins, lupin hulls, mill mix, mill run, pollard, bran, canola meal, soya meal in a rolled, crushed or powdered form, or a mixture thereof; from 0 to about 95 percent lucerne in either chaff, hay, fines or powder form, or a mixture thereof; from 0 to about 95 percent oaten, wheaten or meadow hay in chaff, fines or powder form, or a mixture thereof; and/or from 0 to about 95 percent molasses, and, optionally, additional vitamins and minerals.
  • grain by-products including oats, barley, maize, lupins, lupin hulls, mill mix, mill run, pollard, bran, canola meal, soya meal in a rolled, crushed or powdered form, or a mixture
  • the animal food supplement of the present invention may also contain creatine. Creatine is known in the art, among other benefits, to help increase muscle mass. Creatine may be present from 0 to 95 perecnet by weight. Further, the animal food supplement of the present invention may be formulated to contain from about 1 mg to about 40,000 mg of creatine per serving.
  • the food supplement of the invention preferably contains less than about 8 percent protein.
  • an animal food supplement according to the invention be approximately 11 to 14 percent. It is also currently preferred that an animal food supplement according to the invention contain between about 7.5 and 10 percent lucerne in either chaff, hay, fines or powder form, or a mixture thereof.
  • Pellets of the animal food supplement of the invention are prepared by rolling, crushing and/or powdering grain by-products and other binding agents as described above to achieve a substantially homogenously sized mixture. Psyllium husks are then added to the mixture, whereupon the mixture is treated with steam and extruded through dies, which may range, for example, from 2 to 10 mm in aperture size to form pellets.
  • the packaging according to the invention is substantially hermetic, and a reduced oxygen content atmosphere such as an inert gas, for example, nitrogen, may be introduced into the package during filling thereof with the supplement in an appropriate form (for example, pellets) to displace ambient air present inside the package, providing a sealed environment, generally indicated at 50 , containing the supplement 51 and an atmosphere 52 including less oxygen than ambient air 53 .
  • a reduced oxygen content atmosphere such as an inert gas, for example, nitrogen
  • an appropriate form for example, pellets
  • packaging is provided that allows the food supplement of the invention to “breathe” the atmosphere within the package while preventing or at least reducing the degradation caused by exposure to ambient air.
  • 3-ply paper sacks in which one ply is a 40 ⁇ m BOPP liner, supplied by Australian Multiwall Bag Co. Pty. Ltd. (Murdoch, Australia).
  • the animal food supplement composition may be introduced in pellet form, for example, into the feed box of an animal that is exhibiting symptoms of gastrointestinal problems, such as colic.
  • a dose of about 500 g of the composition is provided on the first day of treatment
  • a dose of about 850 g of the composition is provided on the second day of treatment
  • a dose of about 1000 g of the composition is provided on the third day of treatment
  • a dose of about 2000 g of the composition is provided on the fourth day of treatment
  • a final dose of 2500 g of the composition is provided on the fifth day of treatment.
  • the animal During administration of the food supplement of the present invention, the animal must drink plenty of fresh water on a regular basis, otherwise serious injury may result.
  • the food supplement of the present invention was tested against a placebo in horses.
  • the feces of the horses were monitored for clearance of intestinal detritus, and x-ray imaging was also used to monitor movement of material through the gastrointestinal tracts of the horses.
  • One group of horses was administered the food supplement of the invention according to the above schedule, while a control group was fed a placebo according to the same schedule. All horses that received the food supplement of the invention cleared accumulated intestinal detritus (sand) during the course of treatment, while those in the placebo group either did not clear or cleared very little intestinal detritus.
  • Horses receiving the food supplement of the invention passed as much as 1 ⁇ 4 gallon of sand in feces in a 24-hour period during treatment.
  • promotion of symbiotic bacteria in conjunction with clearance of intestinal detritus and non-symbiotic bacteria through administration of the food supplement of the present invention is useful in promoting growth of the animals, reducing the amount of antibiotics that need to be given to an animal, and in treating not only colic, but also other problems that may be related to gastrointestinal blockage and/or accumulation, such as equine ulcers and founder.
  • the mucus secreted by the goblet cells may also be used to provide a food source to the symbiotic bacteria population in the absence of normal food. For this reason the glycoprotein present in the food supplement of the present invention should not effect the growth, and may even promote the growth, of the symbiotic bacteria.
  • most other normal gut flora e.g. E. coli
  • the increased growth may be due to the promotion of the symbiotic bacteria by 1) providing at least a neutral composition or possible a food source for the symbiotic bacterium, or 2) removing or preventing the growth of other flora allowing the symbiotic bacteria to better compete for limited space and food sources.
  • the symbiotic bacteria population rises, more of the symbiotic bacteria are available for the breakdown of foodstuffs containing complex carbohydrates providing to the animal more useful energy per unit of food consumed, leading to better growth.
  • the food supplement of the present invention may be useful in preventing as well as treating equine ulcers by clearing the equine gut of bacterial deposits.
  • founder chronic laminitis
  • the damaged tissue of the caecum diverts resources such as glucose from the bloodstream as it heals, and founder is believed to result from insufficient nutrient supply to the hoof
  • the present invention is likely useful in treating a variety of animal health problems, as well as for promoting and maintaining general gastrointestinal health in animals.
  • the food supplement of the present invention is useful in many kinds of animals such as, for example, horses, cattle, swine, cats, dogs, chickens, broilers, quail, pheasants, turkeys, ostrich, emus, and other exotic birds.
  • animals such as, for example, horses, cattle, swine, cats, dogs, chickens, broilers, quail, pheasants, turkeys, ostrich, emus, and other exotic birds.
  • the number of days of treatment and the dosages applied to each of these species will vary depending upon the size of the animal and the severity of the symptoms that it exhibits.
  • weanling and yearling horses may be fed at half the rate of an adult horse, and miniature ponies may be administered a dose of one third cup per day for five days.
  • One of ordinary skill in the art in the health care of a given animal will readily be able to determine an appropriate dosage regimen.
  • the above-mentioned treatment schedule may be repeated every ten weeks as a preventive treatment against colic or other gastrointestinal problems.
  • a method of increasing the content of Bacteroides thetaiotamicron in the gut of an animal comprises feeding to the animal a food supplement according to the present invention.
  • the content Bacteroides thetaiotamicron in the gut of the animal may be monitored using standard techniques.
  • One examples of such techniques includes, but is not limited to, assaying the number of Bacteroides thetaiotamicron in a feces sample by spreading the sample on agar plate containing components known to promote the growth of Bacteroides thetaiotamicron and placing the agar plate in an anaerobic environment.
  • the Bacteroides thetaiotamicron content may be determined by counting the number of Bacteroides thetaiotamicron plaques that grow on the plates.
  • a further example of such techniques includes, but is not limited to, performing Polymerase Chain Reaction (PCR) on a feces sample using species specific promoters directed to Bacteroides thetaiotamicron , and relating the number of copies produced to the Bacteroides thetaiotamicron content in the feces sample.
  • PCR Polymerase Chain Reaction
  • a method of decreasing, in an animal, the gastrointestinal content of organisms other than Bacteroides thetaiotamicron comprises feeding to the animal a food supplement according to the present invention.
  • the content of organisms other than Bacteroides thetaiotamicron in the gut of the animal may be monitored using standard techniques.
  • One examples of such techniques includes, but is not limited to, assaying the number of organisms other than Bacteroides thetaiotamicron in a feces sample by spreading the sample on agar plate containing components known to promote the growth of bacteria generally and placing the agar plate in an environment known to promote the growth of bacteria. After a number of days, the bacterial content may be determined by counting the number of bacterial plaques that grow on the plates.
  • a further example of such techniques includes, but is not limited to, performing PCR (Polymerase Chain Reaction) on a feces sample using species specific promoters directed to bacteria other than Bacteroides thetaiotamicron , and relating the number of copies produced to the bacteria content in the feces sample.
  • PCR Polymerase Chain Reaction
  • a method of decreasing the need for antibiotics to be given to an animal comprises feeding to the animal a food supplement according to the present invention.
  • the need for antibiotics can be correlated to the bacterial content of organisms other than Bacteroides thetaiotamicron in the gut of the animal.
  • the content of organisms other than Bacteroides thetaiotamicron in the gut of the animal may be monitored using standard techniques.
  • One examples of such techniques includes, but is not limited to, assaying the number of organisms other than Bacteroides thetaiotamicron in a feces sample by spreading the sample on agar plate containing components known to promote the growth of bacteria generally and placing the agar plate in an environment known to promote the growth of bacteria. After a number of days, the bacterial content may be determined by counting the number of bacterial plaques that grow on the plates.
  • a further example of such techniques includes, but is not limited to, performing PCR on a feces sample using species specific promoters directed to bacteria other than Bacteroides thetaiotamicron , and relating the number of copies produced to the bacteria content in the feces sample.
  • a method of increasing the rate of growth of an immature animal comprises feeding to the animal a food supplement according to the present invention prior or during a growth phase in the animal.
  • Growth rate may be increased by 1% to 200% for a given growth phase when compared to normal or the increase may be in the overall growth of the animal over time when compared to normal.
  • a method of optimizing a feeding regime comprises monitoring the bacterial content in the gut or the growth rate of an animal being fed the food supplement according to the present invention and adjusting the amount of food supplement according to the present invention being fed to an animal based on the bacterial content in the gut or the growth rate of the animal.
  • Growth rate can be measured using standard techniques. Such techniques include, but are not limited to, body mass, body mass index, height, or displacement.
  • Bacterial content in the gut can be monitored as detailed supra.
  • the amount of food supplement in the diet of the animal can be adjusted in reference to growth rate or bacterial content in the gut to achieve the highest growth rate or an optimal bacterial content.
  • the food supplement of the present invention was also discovered to eradicate rodent pests. Rodents that consume the food supplement of the invention die, presumably because the hygroscopic swelling of the psyllium husks blocks or bursts the rodent's gastrointestinal tract. This unexpected benefit of the present invention is particularly advantageous because the same material can be used concurrently to treat gastrointestinal problems in economically significant animals and to eradicate rodent pests.

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Abstract

An animal food supplement particularly useful in treating gastrointestinal problems, such as colic. Psyllium husks are provided in dry form for convenience of handling prior to feeding. In example embodiments, psyllium husks are admixed with binding material and the admixture is formed into pellets, crumbles, mashes, or licks. Upon consumption by the animal, the psyllium husks take up water from the moist environment of the animal's gastrointestinal tract and form a gelatinous bolus that sweeps through the gastrointestinal tract of the animal, clearing the gastrointestinal tract of intestinal detritus, such as sand, toxins, and microorganisms, which agglomerate with and/or are carried away by the psyllium husk gel.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation-in-part of U.S. patent application Ser. No. 10/636,331, filed Aug. 6, 2003, which in turn claims priority from AU200300020441, filed May 29, 2003, the entire disclosure of each of which are incorporated by this reference.
  • BACKGROUND OF THE INVENTION
  • The present invention relates to animal food supplement compositions and methods of using the same, the compositions being particularly useful in relation to, but not limited to, treatment of colic and other gastrointestinal problems in animals.
  • Animal healthcare is an important consideration in many aspects of the economy, such as in food production, research, education (e.g., in zoos) and animal competitions (e.g., horse racing). Productivity, cost control and profitability in these areas of the economy are improved when the health of the animals involved is improved. Efficient and cost-effective animal healthcare is especially important where a substantial investment is required to raise animals to maturity, as is the case with horses.
  • Animals frequently ingest sand, soil, and other extraneous materials when they are grazing or feeding from a feed box that contains such contaminants. Over time, deposits of these extraneous materials accumulate in the digestive system of the animal, causing colic. Colic generally refers to malfunction, swelling, infection, or blockage in the gastrointestinal tract of an animal. As used herein, the term “intestinal detritus” refers to the aforementioned ingested sand, soil, and other extraneous materials accumulated in the gastrointestinal tract of an animal.
  • Instances of colic are particularly distressing for the animal and for the owner, because colic is frequently painful to the animal and difficult to identify and treat. Though an owner may try numerous treatments to relieve the animal's symptoms, unfortunately, previously known treatments often prove ineffective and, unfortunately, animals regularly die as a result of colic. For example, approximately one in ten horses with colic die because no effective treatment has been available in the past.
  • In economically significant animals such as horses, cattle, swine, chickens, broilers, quail, pheasants, turkeys, ostrich, emus, and other exotic birds, gastrointestinal problems such as colic pose a major economic threat. As a result, means for reducing the economic impact of colic, i.e., cost-effective treatments for colic, are in great demand.
  • The present invention overcomes, at least in part, some of the aforementioned disadvantages of prior art treatments for colic and other gastrointestinal problems in animals.
  • BRIEF SUMMARY OF THE INVENTION
  • The present invention provides an animal food supplement particularly useful in treating gastrointestinal problems, such as colic, in horses, cattle, swine, chickens, broilers, quail, pheasants, turkeys, ostrich, emus, and other exotic birds. Psyllium husk is the only natural gelatinous and hygroscopic material that is suitable for consumption by both humans and animals, so it is abundantly available. According to the present invention, psyllium husk may be provided in dry form for convenience of handling prior to feeding. In currently preferred embodiments, psyllium husks may be admixed with binding material having low moisture content, and the admixture is formed into pellets, crumbles, mash, or licks. Upon consumption by the animal, the psyllium husk material takes up water from the moist environment of the animal's gastrointestinal tract and forms a gelatinous bolus that sweeps through the animal's gastrointestinal tract, clearing intestinal detritus, such as sand, soil, toxins, and microorganisms, which agglomerates with and/or is carried away by the psyllium husk gel.
  • A first aspect of the present invention includes an animal food supplement composition including psyllium husk. The animal food supplement may further comprise creatine.
  • A second aspect of the present invention includes a pharmaceutical composition comprising an animal food supplement composition as an active ingredient optionally admixed with a pharmaceutically acceptable carrier, the animal food supplement composition including psyllium husk.
  • A third aspect of the present invention includes a method of using an animal food supplement composition for the preparation of medicaments for the treatment of animal gastrointestinal problems, such as horse colic, wherein the animal food supplement composition includes psyllium husk.
  • A fourth aspect of the present invention includes a packaged animal food supplement composition comprising a substantially hermetic packaging material containing the animal food supplement composition and an atmosphere with a reduced oxygen content in comparison to ambient air.
  • A fifth aspect of the present invention includes a method of using an animal food supplement composition including psyllium husk for reducing the need for antibiotics to be given to an animal.
  • A sixth aspect of the present invention includes a method of using an animal food supplement composition including psyllium husk to increase the content of Bacteroides thetaiotamicron in the gastrointestinal tract of an animal.
  • A seventh aspect of the invention includes a method of using an animal food supplement composition including psyllium husk to decrease the gastrointestinal content of organisms other than Bacteroides thetaiotamicron in an animal.
  • An eighth aspect of the invention includes a method of increasing the rate of growth during a growth period in an animal by providing an animal food supplement composition including psyllium husk to the animal before or during the growth period.
  • A ninth aspect of the invention includes methods of optimizing a feeding regime including an animal food supplement composition comprising psyllium husk, the method comprising monitoring the bacterial content in the feces of an animal.
  • A tenth aspect of the invention includes a method of eradicating rodents comprising distributing in a area where rodents are present a food supplement composition comprising psyllium husk material and at least one binding agent for binding the psyllium husk material in a desired physical form.
  • The present invention advantageously may be incorporated in the ordinary diet of an animal as a treatment for, or preventive measure against, colic and other gastrointestinal problems. An additional advantage of the present invention is that it requires only the use of natural ingredients.
  • Further advantages of the present invention over the state of the art include (but are not limited to) the provision of the animal food supplement according to the invention in a pellet, crumble, mash, or lick form that has a low nutritional value so as to avoid interference with or disruption of the diet of the treated animal and to provide a convenient means by which medication or other dietary supplements, such as vitamins and minerals, may be added to the animal's diet. Through the practice of the present invention, an animal's gastrointestinal tract is cleansed of indigestible matter and toxic deposits for, as appropriate, the prevention and treatment of gastrointestinal problems and improvement of the overall health and well-being of the animal, one result of which is improved economic productivity associated with the animal.
  • BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
  • In the drawings, which illustrate what is currently considered to be the best mode for carrying out the invention:
  • FIG. 1 is a graphical depiction of a pellet physical form of the food supplement composition of the invention.
  • FIG. 2 is a graphical depiction of a crumble physical form of the food supplement composition of the invention.
  • FIG. 3 is a graphical depiction of a mash physical form of the food supplement composition of the invention;
  • FIG. 4 is a graphical depiction of a lick physical form of the food supplement composition of the invention; and
  • FIG. 5 is a graphical depiction of a specialized package containing the food supplement composition of the invention.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention makes beneficial use of the hygroscopic properties of psyllium husks. Psyllium husks swell when they come into contact with water and thus are difficult to handle conveniently when mixed with conventional animal feeds that have a high moisture content, such as molasses and water. Accordingly, it is preferred to provide psyllium husks in dry form for convenience in handling. Upon consumption by the animal, the psyllium husks take up water from the moist environment of the animal's gastrointestinal tract and form a gelatinous bolus that sweeps through the gastrointestinal tract of the animal, clearing the gastrointestinal tract of intestinal detritus, such as sand, soil, toxins, and microorganisms, which agglomerate with and/or are carried away by the psyllium husk gel.
  • However, certain animals, such as horses, will not voluntarily eat dry, unbound psyllium husk material because it is unpalatable. Thus, the mere addition of dry unbound psyllium husks to a feed box is ineffective since the animal may never actually consume the psyllium husks despite their inclusion in the feed box. Accordingly, the present invention provides an animal food supplement that is designed to be palatable to animals for which it is intended, e.g., by using flavors, aromas and textures that appeal to the animal to be treated. The selection of flavors, aromas, and textures appropriate for a given subject, i.e., the design of a palatable product, is well within the skill of the ordinary artisan and is, therefore, not discussed further here.
  • To overcome problems associated with the hygroscopicity of psyllium husks, the present invention provides an animal food supplement prepared from psyllium husks mixed together with a relatively low moisture content binding agent. Preferably, the animal food supplement is extruded into pellet form (as depicted in FIG. 1) for ease of inclusion into the animal's feed box and to ensure consumption thereof by the animal. However, it is also envisaged that the animal food supplement of the invention may be manufactured in a crumble form (as depicted in FIG. 2), a mash form (as depicted in FIG. 3), or an animal lick form (as depicted in FIG. 4).
  • The animal food supplement of the present invention contains from 0 to about 95 percent by weight of psyllium husks in seed, powdered or granulated form, including particulate material comprising stalk, flower and leaf fragments with up to 0 to about 75 percent impurities. It is currently preferred that the food supplement contain about 50 percent psyllium husks. Most preferably according to present beliefs, the food supplement should contain about 30 to 35 percent psyllium husks.
  • The animal food supplement of the present invention may also contain from 0 to about 95 percent grain by-products, including oats, barley, maize, lupins, lupin hulls, mill mix, mill run, pollard, bran, canola meal, soya meal in a rolled, crushed or powdered form, or a mixture thereof; from 0 to about 95 percent lucerne in either chaff, hay, fines or powder form, or a mixture thereof; from 0 to about 95 percent oaten, wheaten or meadow hay in chaff, fines or powder form, or a mixture thereof; and/or from 0 to about 95 percent molasses, and, optionally, additional vitamins and minerals.
  • The animal food supplement of the present invention may also contain creatine. Creatine is known in the art, among other benefits, to help increase muscle mass. Creatine may be present from 0 to 95 perecnet by weight. Further, the animal food supplement of the present invention may be formulated to contain from about 1 mg to about 40,000 mg of creatine per serving.
  • To avoid interference with or disruption of the animal's diet, the food supplement of the invention preferably contains less than about 8 percent protein.
  • It is currently preferred that the moisture content of an animal food supplement according to the invention be approximately 11 to 14 percent. It is also currently preferred that an animal food supplement according to the invention contain between about 7.5 and 10 percent lucerne in either chaff, hay, fines or powder form, or a mixture thereof.
  • Pellets of the animal food supplement of the invention are prepared by rolling, crushing and/or powdering grain by-products and other binding agents as described above to achieve a substantially homogenously sized mixture. Psyllium husks are then added to the mixture, whereupon the mixture is treated with steam and extruded through dies, which may range, for example, from 2 to 10 mm in aperture size to form pellets.
  • The use of proper packaging of the food supplement of the invention is also a significant consideration. If exposed to ambient air, the flavor, aroma and texture of the supplement degrade undesirably over time. However, vacuum packaging is not suitable because the supplement is best preserved if it is allowed to “breathe” without being exposed to ambient air. Thus, another advantageous aspect of the invention is specialized packaging that prevents or reduces the aforementioned degradation.
  • Referring to FIG. 5, the packaging according to the invention is substantially hermetic, and a reduced oxygen content atmosphere such as an inert gas, for example, nitrogen, may be introduced into the package during filling thereof with the supplement in an appropriate form (for example, pellets) to displace ambient air present inside the package, providing a sealed environment, generally indicated at 50, containing the supplement 51 and an atmosphere 52 including less oxygen than ambient air 53. Thus, packaging is provided that allows the food supplement of the invention to “breathe” the atmosphere within the package while preventing or at least reducing the degradation caused by exposure to ambient air. Currently preferred are 3-ply paper sacks, in which one ply is a 40 μm BOPP liner, supplied by Australian Multiwall Bag Co. Pty. Ltd. (Murdoch, Australia).
  • In use, the animal food supplement composition may be introduced in pellet form, for example, into the feed box of an animal that is exhibiting symptoms of gastrointestinal problems, such as colic. In an example treatment for an adult horse, a dose of about 500 g of the composition is provided on the first day of treatment, a dose of about 850 g of the composition is provided on the second day of treatment, a dose of about 1000 g of the composition is provided on the third day of treatment, a dose of about 2000 g of the composition is provided on the fourth day of treatment, and a final dose of 2500 g of the composition is provided on the fifth day of treatment.
  • During administration of the food supplement of the present invention, the animal must drink plenty of fresh water on a regular basis, otherwise serious injury may result.
  • The food supplement of the present invention was tested against a placebo in horses. The feces of the horses were monitored for clearance of intestinal detritus, and x-ray imaging was also used to monitor movement of material through the gastrointestinal tracts of the horses. One group of horses was administered the food supplement of the invention according to the above schedule, while a control group was fed a placebo according to the same schedule. All horses that received the food supplement of the invention cleared accumulated intestinal detritus (sand) during the course of treatment, while those in the placebo group either did not clear or cleared very little intestinal detritus. Horses receiving the food supplement of the invention passed as much as ¼ gallon of sand in feces in a 24-hour period during treatment.
  • In addition, it was also observed that the general health and performance of the animals were improved after receiving the food supplement of the present invention. After treatment, animals were observed to excrete less undigested feed, the condition of their coats improved, and even some inexplicable behavioral problems were resolved. Further animals receiving the food supplement of the present invention during growth phases demonstrate greater than normal growth increases in mass. While not intending to be bound to any particular theory of action, the inventor believes that promotion of symbiotic bacteria in conjunction with clearance of intestinal detritus and non-symbiotic bacteria through administration of the food supplement of the present invention is useful in promoting growth of the animals, reducing the amount of antibiotics that need to be given to an animal, and in treating not only colic, but also other problems that may be related to gastrointestinal blockage and/or accumulation, such as equine ulcers and founder.
  • There is only one symbiote presently known to colonize the human gut—Bacteroides thetaiotamicron. This anaerobic organism is thought to aid digestion thought breakdown of complex carbohydrates into simpler molecules that can be taken up by the gut. Further, it has been recently found that the goblet cells of the intestine, which are normally thought to secrete mucus, secrete packets of cytoplasm containing large numbers of mitochondria. It is currently thought that these mitochondria aid in the creation of a permissive anaerobic environment for Bacteroides thetaiotamicron through the consumption of available oxygen in the gut. The mucus secreted by the goblet cells (a glycoprotein similar to that found in the food supplement of the present invention) may also be used to provide a food source to the symbiotic bacteria population in the absence of normal food. For this reason the glycoprotein present in the food supplement of the present invention should not effect the growth, and may even promote the growth, of the symbiotic bacteria. In contrast, most other normal gut flora (e.g. E. coli) do not grow well (or at all) when streaked across agar plates containing a dilute solution of the food supplement of the present invention.
  • In relation to the increased growth noted in immature animals fed with the food supplement of the present invention, the increased growth may be due to the promotion of the symbiotic bacteria by 1) providing at least a neutral composition or possible a food source for the symbiotic bacterium, or 2) removing or preventing the growth of other flora allowing the symbiotic bacteria to better compete for limited space and food sources. As the symbiotic bacteria population rises, more of the symbiotic bacteria are available for the breakdown of foodstuffs containing complex carbohydrates providing to the animal more useful energy per unit of food consumed, leading to better growth.
  • Research is ongoing to determine whether equine ulcers are caused by bacteria, as are ulcers in humans. If so, the food supplement of the present invention may be useful in preventing as well as treating equine ulcers by clearing the equine gut of bacterial deposits. Further, it is believed that founder (chronic laminitis) can be caused by toxic accumulations in the caecum, which kill off beneficial bacteria and damage the wall of the caecum. The damaged tissue of the caecum diverts resources such as glucose from the bloodstream as it heals, and founder is believed to result from insufficient nutrient supply to the hoof Thus, the present invention is likely useful in treating a variety of animal health problems, as well as for promoting and maintaining general gastrointestinal health in animals.
  • The food supplement of the present invention is useful in many kinds of animals such as, for example, horses, cattle, swine, cats, dogs, chickens, broilers, quail, pheasants, turkeys, ostrich, emus, and other exotic birds. Of course, it is contemplated that the number of days of treatment and the dosages applied to each of these species will vary depending upon the size of the animal and the severity of the symptoms that it exhibits. For example, weanling and yearling horses may be fed at half the rate of an adult horse, and miniature ponies may be administered a dose of one third cup per day for five days. One of ordinary skill in the art in the health care of a given animal will readily be able to determine an appropriate dosage regimen. In general, it is currently preferred to administer the food supplement of the invention for five days with gradually increasing daily doses.
  • The above-mentioned treatment schedule, or one similar thereto, may be repeated every ten weeks as a preventive treatment against colic or other gastrointestinal problems.
  • In one example of an embodiment of the present invention, a method of increasing the content of Bacteroides thetaiotamicron in the gut of an animal is disclosed. The method comprises feeding to the animal a food supplement according to the present invention. The content Bacteroides thetaiotamicron in the gut of the animal may be monitored using standard techniques. One examples of such techniques includes, but is not limited to, assaying the number of Bacteroides thetaiotamicron in a feces sample by spreading the sample on agar plate containing components known to promote the growth of Bacteroides thetaiotamicron and placing the agar plate in an anaerobic environment. After a number of days, the Bacteroides thetaiotamicron content may be determined by counting the number of Bacteroides thetaiotamicron plaques that grow on the plates.
  • A further example of such techniques includes, but is not limited to, performing Polymerase Chain Reaction (PCR) on a feces sample using species specific promoters directed to Bacteroides thetaiotamicron, and relating the number of copies produced to the Bacteroides thetaiotamicron content in the feces sample.
  • In a further example embodiment of the present invention, a method of decreasing, in an animal, the gastrointestinal content of organisms other than Bacteroides thetaiotamicron. The method comprises feeding to the animal a food supplement according to the present invention. The content of organisms other than Bacteroides thetaiotamicron in the gut of the animal may be monitored using standard techniques. One examples of such techniques includes, but is not limited to, assaying the number of organisms other than Bacteroides thetaiotamicron in a feces sample by spreading the sample on agar plate containing components known to promote the growth of bacteria generally and placing the agar plate in an environment known to promote the growth of bacteria. After a number of days, the bacterial content may be determined by counting the number of bacterial plaques that grow on the plates.
  • A further example of such techniques includes, but is not limited to, performing PCR (Polymerase Chain Reaction) on a feces sample using species specific promoters directed to bacteria other than Bacteroides thetaiotamicron, and relating the number of copies produced to the bacteria content in the feces sample.
  • In another example embodiment of the present invention, a method of decreasing the need for antibiotics to be given to an animal is disclosed. The method comprises feeding to the animal a food supplement according to the present invention. The need for antibiotics can be correlated to the bacterial content of organisms other than Bacteroides thetaiotamicron in the gut of the animal. The content of organisms other than Bacteroides thetaiotamicron in the gut of the animal may be monitored using standard techniques. One examples of such techniques includes, but is not limited to, assaying the number of organisms other than Bacteroides thetaiotamicron in a feces sample by spreading the sample on agar plate containing components known to promote the growth of bacteria generally and placing the agar plate in an environment known to promote the growth of bacteria. After a number of days, the bacterial content may be determined by counting the number of bacterial plaques that grow on the plates.
  • A further example of such techniques includes, but is not limited to, performing PCR on a feces sample using species specific promoters directed to bacteria other than Bacteroides thetaiotamicron, and relating the number of copies produced to the bacteria content in the feces sample.
  • In a yet further example embodiment of the present invention, a method of increasing the rate of growth of an immature animal is disclosed. The method comprises feeding to the animal a food supplement according to the present invention prior or during a growth phase in the animal. Growth rate may be increased by 1% to 200% for a given growth phase when compared to normal or the increase may be in the overall growth of the animal over time when compared to normal.
  • In an additional example embodiment of the present invention, a method of optimizing a feeding regime is disclosed. The method comprises monitoring the bacterial content in the gut or the growth rate of an animal being fed the food supplement according to the present invention and adjusting the amount of food supplement according to the present invention being fed to an animal based on the bacterial content in the gut or the growth rate of the animal. Growth rate can be measured using standard techniques. Such techniques include, but are not limited to, body mass, body mass index, height, or displacement. Bacterial content in the gut can be monitored as detailed supra. The amount of food supplement in the diet of the animal can be adjusted in reference to growth rate or bacterial content in the gut to achieve the highest growth rate or an optimal bacterial content.
  • Surprisingly, the food supplement of the present invention was also discovered to eradicate rodent pests. Rodents that consume the food supplement of the invention die, presumably because the hygroscopic swelling of the psyllium husks blocks or bursts the rodent's gastrointestinal tract. This unexpected benefit of the present invention is particularly advantageous because the same material can be used concurrently to treat gastrointestinal problems in economically significant animals and to eradicate rodent pests.
  • Although the present invention has been described with respect to the currently preferred embodiments set forth herein, various additions, deletions and modifications are contemplated as being within its scope. The scope of the invention is, therefore, indicated by the ensuing claims, rather than the foregoing description. All changes that come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims (36)

1. A method of treating or preventing a gastrointestinal problem in an animal, comprising administering to the animal a food supplement composition comprising:
psyllium husk material; and
at least one binding agent for binding the psyllium husk material in a desired physical form.
2. The method according to claim 1, wherein the food supplement composition comprises:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
3. The method according to claim 2, wherein the food supplement composition further comprises between about 0.001 to 70 percent creatine.
4. The method according to claim 1, wherein the gastrointestinal problem is colic.
5. A method of treating or preventing a gastrointestinal problem in an animal, comprising administering to the animal a food supplement composition comprising psyllium husk material and at least one binding agent for binding the psyllium husk material in a desired physical form according to the following schedule:
(a) about 500 g on a first day of treatment;
(b) about 850 g on a second day of treatment;
(c) about 1000 g on a third day of treatment;
(d) about 2000 g on a fourth day of treatment; and
(e) about 2500 g on a fifth day of treatment.
6. The method according to claim 5 further comprising repeating the schedule about every ten weeks.
7. The method according to claim 5 wherein the animal is a horse.
8. The method according to claim 5, wherein the food supplement composition comprises:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
9. The method according to claim 8, wherein the food supplement composition further comprises between about 0.001 and 70 percent creatine.
10. A method for eradicating rodents, comprising distributing in an area where rodents are present a food supplement composition comprising:
psyllium husk material; and
at least one binding agent for binding the psyllium husk material in a desired physical form.
11. A solid food supplement composition for a non-human animal, comprising:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form;
creatine; and
a moisture content of approximately 11 to 14 percent.
12. The food supplement composition of claim 11, wherein the creatine is present at from about 0.001 to 95 percent by weight.
13. The food supplement composition of claim 11, wherein the food supplement composition is sufficiently low in nutritional value so as to avoid interference with or disruption of the diet of the non-human animal ingesting the food supplement composition.
14. The food supplement composition of claim 11, further comprising at least one grain by-product selected from the group consisting essentially of oats, barley, maize, lupins, lupin hulls, bran, canola meal, and soya meal.
15. The food supplement composition of claim 11, further comprising hay.
16. The food supplement composition of claim 15, wherein the hay is at least one of oaten, wheaten, and meadow hay.
17. The food supplement composition of claim 11, further comprising at least one pharmaceutical composition.
18. The food supplement composition of claim 11, further comprising at least one nutrient.
19. The food supplement composition of claim 18, wherein the at least one nutrient is at least one of a vitamin and a mineral.
20. The food supplement composition of claim 11, wherein the desired physical form is a pellet, a crumble, a mash, or a lick.
21. The food supplement composition of claim 11, further comprising a flavoring.
22. The food supplement composition of claim 11, wherein the flavoring includes molasses.
23. A substantially hermetic package containing a solid food supplement composition, the substantially hermetic package containing an atmosphere having less oxygen than ambient air, the solid food supplement composition comprising:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent for binding the psyllium husk material in a desired physical form;
creatine; and
a moisture content of approximately 11 to 14 percent.
24. A method of increasing the amount of Bacteroides thetaiotamicron in the gut of an animal, the method comprising:
feeding the animal a food composition comprising psyllium husk.
25. The method according to claim 24, further comprising formulating the food composition to comprise:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
26. A method of decreasing the amount of organisms other than Bacteroides thetaiotamicron in the gut of an animal, the method comprising:
feeding the animal a food composition comprising psyllium husk.
27. The method according to claim 26, further comprising formulating the food composition to comprise:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
28. A method of increasing the rate of growth during a growth period in animal, the method comprising:
feeding the animal a food composition comprising psyllium husk.
29. The method according to claim 28, further comprising formulating the food composition to comprise:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
30. The method according to claim 28 further comprising increasing the growth rate of the animal by about 1% to about 200% when compared to the normal growth rate.
31. A method of reducing the need for antibiotics to be given to an animal, the method comprising:
feeding the animal a food composition comprising psyllium husk.
32. The method according to claim 31, further comprising formulating the food composition to comprise:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
33. A method of optimizing an animal feeding regime of a food composition comprising psyllium husk, the method comprising:
monitoring the bacterial content in the gut or feces of the animal; and
adjusting the amount of the food composition in the diet of the animal;
wherein the adjusting of the amount of the food composition in the diet of the animal alters the bacterial content in the gut or feces of the animal.
34. The method according to claim 33, further comprising formulating the food composition to comprise:
between about 30 to 35 percent psyllium husk material;
less than about 8 percent protein;
between about 7.5 to 10 percent lucerne;
at least one binding agent binding the psyllium husk material in a desired physical form; and
a moisture content of approximately 11 to 14 percent.
35. The method according to claim 33, wherein adjusting the amount of the food composition in the diet of the animal increases the content of Bacteroides thetaiotamicron in the gut or feces of the animal.
36. The method according to claim 33, wherein a wherein adjusting the amount of the food composition in the diet of the animal decreases the content of organisms other than Bacteroides thetaiotamicron in the gut or feces of the animal.
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