US20050187482A1 - Implantable wireless sensor - Google Patents
Implantable wireless sensor Download PDFInfo
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- US20050187482A1 US20050187482A1 US10/943,772 US94377204A US2005187482A1 US 20050187482 A1 US20050187482 A1 US 20050187482A1 US 94377204 A US94377204 A US 94377204A US 2005187482 A1 US2005187482 A1 US 2005187482A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
- A61B5/02014—Determining aneurysm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/076—Permanent implantations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/49016—Antenna or wave energy "plumbing" making
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/4902—Electromagnet, transformer or inductor
- Y10T29/49069—Data storage inductor or core
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/4902—Electromagnet, transformer or inductor
- Y10T29/49071—Electromagnet, transformer or inductor by winding or coiling
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/4902—Electromagnet, transformer or inductor
- Y10T29/49073—Electromagnet, transformer or inductor by assembling coil and core
Definitions
- the application is directed to an implantable wireless sensor. More particularly, this invention is directed to a wireless, unpowered, micromechanical sensor that can be delivered using endovascular techniques, to measure a corporeal parameter such as pressure or temperature.
- Abdominal aortic aneurysms represent a dilatation and weakening of the abdominal aorta which can lead to aortic rupture and sudden death.
- the medical treatment of abdominal aortic aneurysms required complicated surgery with an associated high risk of injury to the patient.
- endografts (combining stents and grafts into a single device) have been developed that can be inserted through small incisions in the groin. Once in place, these endografts seal off the weakened section of the aorta. The aneurysms can then heal, eliminating the risk of sudden rupture.
- This less invasive form of treatment for abdominal aortic aneurysms has rapidly become the standard of care for this disease.
- An example of an endograft device is disclosed in Kornberg, U.S. Pat. No. 4,617,932.
- a significant problem with endografts is that, due to inadequate sealing of the graft with the aorta, leaks can develop that allow blood to continue to fill the aneurysmal sac. Left undiscovered, the sac will continue to expand and potentially rupture.
- endograft treatment for their abdominal aortic aneurysms are subjected to complex procedures that rely on injection of contrast agents to visualize the interior of the aneurysm sac. These procedures are expensive, not sensitive, and painful. In addition, they subject the patient to additional risk of injury.
- An ideal method of accomplishing all of the above objectives would be to place a device capable of measuring pressure within the aneurysm sac at the time of endograft insertion.
- a device capable of measuring pressure within the aneurysm sac at the time of endograft insertion.
- the physician will obtain an immediate assessment of the success of the endograft at time of the procedure, and outpatient follow-up visits will allow simple monitoring of the success of the endograft implantation.
- Van Bockel An example of an implantable pressure sensor designed to monitor pressure increases within an aneurysmal sac is shown in Van Bockel, U.S. Pat. No. 6,159,156. While some of the above objectives are accomplished, this device has multiple problems that would make its use impractical. For example, the sensor system disclosed in the Van Bockel patent relies on a mechanical sensing element that cannot be practically manufactured in dimensions that would allow for endovascular introduction. In addition, this type of pressure sensor would be subject to many problems in use that would limit its accuracy, stability and reliability. One example would be the interconnection of transponder and sensor as taught by Van Bockel, such interconnection being exposed to body fluids which could disrupt its function. This would impact the device's ability to maintain accurate pressure reading over long periods of time.
- a fundamental problem with sensors is their tendency to drift over time.
- a sensor described in the Van Bockel patent would be subject to drift as a result of its failure to seal the pressure sensing circuit from the external environment.
- the Van Bockel device requires a complex system for acquiring data from the sensor necessary for the physician to make an accurate determination of intra-aneurysmal pressure.
- the present invention comprises a device that can be implanted into the human body using non-surgical techniques to measure a corporeal parameter such as pressure, temperature, or both.
- a corporeal parameter such as pressure, temperature, or both.
- Specific target locations could include the interior of an abdominal aneurysm or a chamber of the heart.
- This sensor is fabricated using MicroElectroMechanical Systems (MEMS) technology, which allows the creation of a device that is small, accurate, precise, durable, robust, biocompatible, radiopaque and insensitive to changes in body chemistry, biology or external pressure.
- MEMS MicroElectroMechanical Systems
- the MEMS approach to sensor design lends itself to the fabrication of small sensors that can be formed using biocompatible materials as substrate materials.
- the pressure sensor described above can be introduced into the sac of an abdominal aneurysm at the time an endograft is deployed within the aorta by using standard endovascular catheter techniques.
- Appropriately biocompatible coatings may be applied to the surface of the sensor to prevent adhesion of biological substances or coagulated blood to the sensor that could interfere with its proper function.
- an implantable wireless sensor comprises two substrates, at least one of which has a recess.
- the sensor comprises a self-contained resonant circuit comprising a capacitor and an inductor, where the circuit is variable in response to a physical property, or changes in a physical property, of a patient.
- the substrates are sealed together to form a hermetically scaled chamber, preferably one that is pressure sensitive.
- one surface of each substrate comprises an inductor coil such as a wire spiral arranged in planar fashion.
- the wire spirals are in planes parallel to each other.
- each inductor coil is connected by a wire to a capacitor plate arranged in the middle of the respective coil.
- the capacitor plates are substantially planar to the respective inductor coils and are substantially arranged parallel to each other.
- the senor may comprise a metallic basket arranged exterior to the substrates.
- Delivery of the device of the invention to an aneurysm may be accomplished as follows: Using the standard Seldinger technique, the physician gains access to the patient's femoral artery and places a vessel introducer with a hemostatic valve. Under direct fluoroscopic visualization, a flexible guidewire is inserted through the introducer catheter and maneuvered such that its tip is stationed within the sac of the aortic aneurysm. A standard vessel introducer is inserted over the guidewire and through the introducer and advanced distally until its tip is within the aneurysmal sac. The inner dilator of the vessel introducer is removed and a sensor delivery vehicle is inserted the inner lumen of introducer.
- the delivery vehicle consists of a polymer support tube with two channels that run through its length, a metal or rigid sensor support capsule in which the sensor is placed and atraumatic tip.
- the sensor is attached to a tethering system consisting of a hollow tube with small diameter flexible wire disposed within. Near the terminal end of the hollow tube, a small break in the tube's surface is made. The flexible tether wire emerges out of this break, is threaded through a small hole in the rear section of the sensor, placed over the sensor, inserted through an identical hole in the forward segment of the sensor and re-inserted back into the hollow tube in a similar break in the tube's surface. In this configuration, the sensor remains secured to the tether wire after the delivery vehicle is removed from the patient. Following the insertion and deployment of the stent-graft, the sensor is detached from the tether wire by simply retracting the wire from the hollow tube. Once the wire has been pulled through the two holes in the sensor, the sensor is released into the aneurysm sac and the wire and hollow tube are removed.
- FIG. 1 is an oblique perspective view of an embodiment of the invention
- FIG. 2 is a top, partly cross-sectional view of the embodiment of the invention shown in FIG. 1 ;
- FIG. 3 is a top, partly cross-sectional view of another embodiment of the invention.
- FIG. 4 is an oblique, cross-sectional view of the embodiment of the invention shown in FIG. 2 ;
- FIG. 5 is an oblique, cross-sectional view of the embodiment of the invention shown in FIG. 3 ;
- FIG. 6 is a exposed cross-sectional view of the embodiment of the invention shown in FIG. 5 ;
- FIG. 7 shows part of the sensor tethering system
- FIG. 8 shows the further details of the tethering system
- FIGS. 9 to 12 show additional details of the tethering system
- FIGS. 13 to 15 show details of the delivery system
- FIGS. 16 to 26 show details of the manufacturing process used to fabricate the invention
- FIG. 27 represents an additional embodiment of the invention.
- FIG. 28 is a schematic of a control system.
- FIG. 1 is an oblique, perspective view of a sensor 2 , an embodiment of the invention.
- Sensor 2 preferably has an outer coating of biocompatible silicone.
- FIG. 2 is a top, partial cross-section of a schematic representation of sensor 2 where a wire spiral inductor coil 4 is positioned in planar fashion in a substrate 6 .
- sensor 2 may have recesses 8 , each with a hole 10 , to receive a tether wire (not shown here) for delivery of the device into a human patient, as described below.
- a wire 12 connects coil 4 to a capacitor plate 14 positioned within coil 4 .
- FIG. 4 is a slightly oblique cross-section across its width of the embodiment of the invention shown in FIG. 2 , where it can be seen that sensor 2 is comprised of a lower substrate 20 and an upper substrate 22 .
- Lower substrate 20 and upper substrate 22 are constructed from a suitable material, such as glass, fused silica, sapphire, quartz, or silicon. Fused silica is the preferred material of construction.
- Lower substrate 20 has on its upper surface 24 an induction coil 26
- upper substrate 22 has a recess 28 with a surface 30 having an induction coil 32 thereon.
- the top surface of upper substrate 22 forms a membrane 34 capable of mechanically responding to changes in a patient's physical property, such as pressure.
- the end 36 of sensor 2 has a notch or recess 38 .
- FIG. 5 is a slightly oblique cross-section across its width of the embodiment of the invention shown in FIG. 3 .
- the primary difference between FIGS. 4 and 5 is the presence of upper capacitor plate 42 and lower capacitor plate 44 on surfaces 24 and 30 , respectively.
- the spiral coil 4 itself acts as the capacitive element of the LC circuit that describes the operation of the sensor.
- FIG. 6 is a variation of FIG. 5 where the outline of upper substrate 22 is shown but the details of lower substrate 20 can be seen more clearly, including individual coils of inductor coil 26 .
- a wire 46 connects lower capacitor plate 44 to induction coil 26 .
- the size of the sensors of the invention will vary according to factors such as the intended application, the delivery system, etc.
- the oval sensors are intended to be from about 0.5 in. to about 1 in. in length and from about 0.1 in. to about 0.5 in. in width, with a thickness of from about 0.05 in. to about 0.30 in.
- upper substrate 22 can be significantly thinner than lower substrate 20 .
- upper substrate 22 may be from about 100 to about 300 microns thick, whereas lower substrate 20 may be from about 500 to about 1500 microns thick.
- both substrates may be of the same thickness ranging from about 100 to about 1000 microns.
- a sensor 50 is attached to a hollow tube 52 that has a flexible tip 54 .
- FIG. 8 shows the sensor 50 and specific features of the tethering system, namely proximal holes 56 and distal holes 58 disposed in a hollow tube 52 .
- FIG. 9 shows a tether wire 60 that is attached to sensor 50 at sensor holes 62 and hollow tube holes 56 and 58 , and a tether wire 60 is positioned slidably within a hollow tube 52 .
- FIG. 10 shows a vessel introducer 66 and the delivery system 68 .
- a double lumen tube 70 has one channel that accepts a guidewire 72 and a second channel that accepts the sensor tether wire.
- the guidewire 72 can be advanced through hub 74 .
- a rigid delivery capsule 78 is disposed at the far end of the delivery catheter and flexible tip 80 is connected to the catheter via a hollow tube 81 extending through the delivery capsule 78 .
- a sensor 82 is positioned inside a slot in the delivery capsule 78 proximal to flexible tip 80 .
- FIG. 12 shows a lateral, cross-sectional view of this arrangement where the sensor 82 is inside the slot of delivery capsule 78 and the flexible tip 84 of the tether wire is disposed between the end of delivery capsule 78 and flexible tip 80 .
- FIG. 13 shows delivery catheter 68 loaded into the previously placed vessel introducer 66 prior to introduction of the sensor into the body.
- FIG. 14 shows that the sensor 82 on tether tube 52 has been advanced out of delivery capsule 78 and the delivery catheter has been removed.
- the tether wire has been retracted into the hollow tether tube, releasing the sensor.
- the tether wire, tether tube and vessel introducer 66 are then all removed.
- the pressure sensor of the invention can be manufactured using Micro-machining techniques that were developed for the integrated circuit industry.
- An example of this type of sensor features an inductive-capacitive (LC) resonant circuit with a variable capacitor, as is described in Allen et al., U.S. Pat. Nos. 6,111,520 and 6,278,379, all of which are incorporated herein by reference.
- the sensor contains two types of passive electrical components, namely, an inductor and a capacitor.
- the sensor is constructed so that the fluid pressure at the sensor's surface changes the distance between the capacitor's substantially parallel plates and causes a variation of the sensor's capacitance.
- the senor of the invention is constructed through a series of steps that use standard MEMS manufacturing techniques.
- FIG. 16 shows the first step of this process in which a thin layer of metal (Protective mask) 90 is deposited onto the top and bottom surface of a fused silica wafer 92 (alternative materials would be glass, quartz, silicon or ceramic). Wafer diameters can range from about 3 to about 6 in. Wafer thickness can range from about 100 to about 1500 microns. A pattern mask is then created on one side of the wafer to define the location of cavities that need to be etched into the surface.
- a thin layer of metal (Protective mask) 90 is deposited onto the top and bottom surface of a fused silica wafer 92 (alternative materials would be glass, quartz, silicon or ceramic).
- Wafer diameters can range from about 3 to about 6 in.
- Wafer thickness can range from about 100 to about 1500 microns.
- a pattern mask is then created on one side of the wafer to define the location of cavities that need to be etched into the surface.
- FIG. 17 shows trenches or cavities 94 are etched into one surface of the wafer 92 to depths ranging from about 20 to about 200 microns. This etching is accomplished using any combination of standard wet and dry etching techniques (acid etch, plasma etch, reactive ion etching) that are well known in the MEMS industry. The protective metal mask is removed using standard metal etching techniques.
- a thin metal seed layer 96 (typically chromium) is deposited on the etched side of the wafer using standard metal deposition techniques such as sputtering, plating or metal evaporation.
- a layer of photo-resistive material 98 is applied to the etched surface of the wafer using standard spin coating procedures.
- FIG. 20 shows that a mask aligner and UV light 102 is used in a photolithographic processes to transfer a pattern from a mask 104 to the photoresist coating on the wafer.
- FIG. 22 shows copper 108 electroplated into the mold to the desired height, typically from about 5 to about 35 microns.
- the Photoresist 110 and seed layer 112 are etched away leaving the plated copper coils 114 .
- This process is then repeated with a second wafer.
- the two processed wafers 118 and 120 are aligned such that the cavities 122 and 124 with plated coils are precisely orientated in over one another and temporarily bonded to each other.
- FIGS. 25 and 26 show that by using a CO 2 laser 126 (or other appropriate laser type), the individual sensors 130 are cut from the glass wafer.
- the laser cutting process results in a permanent, hermetic seal between the two glass wafers.
- the laser energy is confined to a precise heat effect zone 128 in which the hermetic seal is created.
- FIG. 27 represents an embodiment of the invention wherein a sensor 132 attached to a delivery catheter 134 has a stabilizer or basket 136 .
- the stabilizer can be any appropriate device or structure that can be fixedly attached to a sensor of the invention to assist the sensor in maintaining position, location, and/or orientation after the sensor is delivered to an intended site.
- the stabilizer can comprise any appropriate physiologically acceptable rigid or slightly flexible material, such as stainless steel, nitinol, or a radiopaque metal or alloy.
- This sensor design provides many important benefits to sensor performance.
- the hermetic seal created during the laser cutting process coupled with the design feature that the conductor lines of the sensor are sealed within the hermetic cavity, allows the sensor to remain stable and drift free during long time exposures to body fluids. In the past, this has been a significant issue to the development of sensors designed for use in the human body.
- the manufacturing methodology described above allows many variations of sensor geometry and electrical properties. By varying the width of the coils, the number of turns and the gap between the upper and lower coils the resonant frequency that the device operates at and the pressure sensitivity (i.e., the change in frequency as a result of membrane deflection) can be optimized for different applications.
- the design allows for a very small gap between the coils (typically between about 3 and about 35 microns) that in turn provides a high degree of sensitivity while requiring only a minute movement of the coils to sense pressure changes. This is important for long term durability, where large membrane deflection could result in mechanical fatigue of the pressure sensing element.
- the thickness of the sensor used can also be varied to alter mechanical properties. Thicker wafers are more durable for manufacturing. Thinner sensors allow for creating of thin pressure sensitive membranes for added sensitivity.
- the sensors may be manufactured using wafers of different thicknesses. For example, one side of the sensor may be constructed from a sensor of approximate thickness of 200 microns. This wafer is manufactured using the steps outlined above. Following etching, the thickness of the pressure sensitive membrane (i.e., the bottom of the etched trench) is in the range of from about 85 to about 120 microns.
- the matching wafer is from about 500 to about 1000 microns thick.
- the trench etching step is eliminated and the coils are plated directly onto the flat surface of the wafer extending above the wafer surface a height of from about 20 to about 40 microns.
- the appropriate gap between the top and bottom coils is created to allow operation preferably in a frequency range of from 30 to 45 MHz and have sensitivity preferably in the range of from 5 to 15 kHz per millimeter of mercury. Due to the presence of the from about 500 to about 1000 micron thick wafer, this sensor will have added durability for endovascular delivery and for use within the human body.
- the sensor exhibits the electrical characteristics associated with a standard LC circuit.
- An LC circuit can be described as a closed loop with two major elements, a capacitor and an inductor. If a current is induced in the LC loop, the energy in the circuit is shared back and forth between the inductor and capacitor. The result is an energy oscillation that will vary at a specific frequency. This is termed the resonant frequency of the circuit and it can be easily calculated as its value is dependent on the circuit's inductance and capacitance. Therefore, a change in capacitance will cause the frequency to shift higher or lower depending upon the change in the value of capacitance.
- the capacitor in the assembled pressure sensor consists of the two circular conductive segments separated by an air gap. If a pressure force is exerted on these segments it will act to move the two conductive segments closer together. This will have the effect of reducing the air gap between them which will consequently change the capacitance of the circuit. The result will be a shift in the circuit's resonant frequency that will be in direct proportion to the force applied to the sensor's surface.
- the inductor Because of the presence of the inductor, it is possible to electromagnetically couple to the sensor and induce a current in the circuit. This allows for wireless communication with the sensor and the ability to operate it without the need for an internal source of energy such as a battery.
- the sensor if the sensor is located within the sac of an aortic aneurysm, it will be possible to determine the pressure within the sac in a simple, non-invasive procedure by remotely interrogating the sensor, recording the resonant frequency and converting this value to a pressure measurement.
- the readout device generates electromagnetic energy that penetrates through the body's tissues to the sensor's implanted location.
- the sensor's electrical components absorb a fraction of the electromagnetic energy that is generated by the readout device via inductive coupling.
- This coupling induces a current in the sensor's circuit that oscillates at the same frequency as the applied electromagnetic energy. Due to the nature of the sensor's electromechanical system there exists a frequency of alternating current at which the absorption of energy from the readout device is at a maximum. This frequency is a function of the capacitance of the device. Therefore, if the sensor's capacitance changes, so will the optimal frequency at which it absorbs energy from the readout device. Since the sensor's capacitance is mechanically linked to the fluid pressure at the sensor's surface, a measurement of this frequency by the readout device gives a relative measurement of the fluid pressure. If calibration of the device is performed, then an absolute measurement of pressure can be made. See, for example, the extensive discussion in the Allen et al.
- the pressure sensor is made of completely passive components having no active circuitry or power sources such as batteries.
- the pressure sensor is completely self-contained having no leads to connect to an external circuit or power source.
- these same manufacturing techniques can be used to add additional sensing capabilities, such as the ability to measure temperature by the addition of a resistor to the basic LC circuit or by utilizing changes in the back pressure of gas intentionally sealed within the hermetic pressure reference to change the diaphragm position and therefore the capacitance of the LC circuit.
- the frequency response to the sensor will be in the range of from about 1 to about 200 MHz, preferably from about 1 to about 100 MHz, and more preferably from about 2 to about 90 MHz, and even more preferably from about 30 to about 45 MHz, with a Q factor of from about 5 to about 150, optimally from about 5 to about 80, preferably from about 40 to about 100, more preferably from about 50 to about 90.
- the device is constructed using multiple layers upon lie the necessary circuit elements. Disposed on the top and bottom layer are metal patterns constructed using micro-machining techniques which define a top and bottom conductor and a spiral inductor coil. To provide for an electrical contact between the top and bottom layers small vias or holes are cut through the middle layers. When the layers are assembled, a metal paste is forced into the small vias to create direct electrical connections or conduits.
- a vialess operational LC circuit can be created. This absence of via holes represents a significant improvement to the sensor in that it simplifies the manufacturing process and, more importantly, significantly increases the durability of the sensor making it more appropriate for use inside the human body.
- the invention is not limited to the implantation of a single sensor. Multiple pressure sensors may be introduced into the aneurysm space, each being positioned at different locations. In this situation, each sensor may be designed with a unique signature (obtained by changing the resonant frequency of the sensor), so that the pressure measurement derived from one sensor can be localized to its specific position within the aneurysm.
- Q Quality factor
- the transmitted energy will decay exponentially as it travels away from the sensor, the lower the energy available to be transmitted, the faster it will decay below a signal strength that can be detected by the receiving antenna and the closer the sensor needs to be situated relative to the receiving electronics. In general then, the lower the Q, the greater the energy loss and the shorter the distance between sensor and receiving antenna required for sensor detection.
- the Q of the sensor will be dependent on multiple factors such as the shape, size, diameter, number of turns, spacing between turns and cross-sectional area of the inductor component.
- Q will be greatly affected by the materials used to construct the sensors. Specifically, materials with low loss tangents will provide the sensor with higher Q factors.
- the implantable sensor ascending to the invention is preferably constructed of various glasses or ceramics including but not limited to fused silica, quartz, pyrex and sintered zirconia, that provide the required biocompatibility, hermeticity and processing capabilities.
- the materials result in a high Q factor.
- These materials are considered dielectrics, that is, they are poor conductors of electricity, but are efficient supporters of electrostatic or electroquasiatatic fields.
- An important property of dielectric materials is their ability to support such fields while dissipating minimal energy. The lower the dielectric loss (the proportion of energy lost), the more effective the dielectric material in maintaining high Q. For a lossy dielectric material, the loss is described by the property termed “loss tangent.” A large loss tangent reflects a high degree of dielectric loss.
- potential encapsulation material must have the flexibility and biocompatibility characteristics of the sensor material and also be sufficiently compliant to allow transmission of fluid pressure to the pressure sensitive diaphragm.
- a preferred material for this application is polydimethylsiloxane (silicone).
- a thin (i.e., 200 micron) coating of silicone was applied to the sensor detailed above.
- This coating provided sufficient insulation to maintain the Q at 50 in a conductive medium. Equally important, despite the presence of the silicone, adequate sensitivity to pressure changes was maintained and the sensor retained sufficient flexibility to be folded for endovascular delivery.
- One additional benefit of the silicone encapsulation material is that it can be optionally loaded with a low percentage (i.e., 10-20%) of radio-opaque material (e.g., barium sulfate) to provide visibility when examined using fluoroscopic x-ray equipment. This added barium sulfate will not affect the mechanical and electrical properties of the silicone.
- the Q factor of a sensor it is desirable to increase the Q factor of a sensor, and the Q factor can be increased by suitable selection of sensor materials or a coating, or both. Preferably both are used, because the resulting high Q factor of a sensor prepared in this fashion is especially suitable for the applications described.
- the pressure sensor When introduced into the sac of an abdominal aorta, the pressure sensor can provide pressure related data by use of an external measuring device.
- an external measuring device As disclosed in the Allen et al. patents, several different excitation systems can be used.
- the readout device generates electromagnetic energy that can penetrate through the body's tissues to the sensor's implanted location.
- the sensor's electrical components can absorb a fraction of the electromagnetic energy that is generated by the readout device via inductive coupling. This coupling will induce a current in the sensor's circuit that will oscillate at the same frequency as the applied electromagnetic energy. Due to the nature of the sensor's electromechanical system there will exist a frequency of alternating current at which the absorption of energy from the readout device is at a minimum. This frequency is a function of the capacitance of the device.
- the sensor's capacitance changes so will the frequency at which it minimally absorbs energy from the readout device. Since the sensor's capacitance is mechanically linked to the fluid pressure at the sensor's surface, a measurement of this frequency by the readout device can give a relative measurement of the fluid pressure. If calibration of the device is performed then an absolute measurement of pressure can be made.
- the circuitry used to measure and display pressure is contained within a simple to operate, portable electronic unit 400 , as shown in FIG. 28 .
- This unit 400 also contains the antenna needed to perform the electromagnetic coupling to the sensor.
- the antenna may be integrated into the housing for the electronics or it may be detachable from the unit so that it can be positioned on the surface of the body 402 in proximity to the implanted sensor and easily moved to optimize the coupling between antenna and sensor.
- the antenna itself may consist of a simple standard coil configuration or my incorporate ferrous elements to maximize the coupling efficiency.
- the electronic device would feature an LCD or LED display 404 designed to clearly display the recorded pressure in physiologically relevant units such as mm Hg.
- the display may be created by integrating a commercially available hand-held computing device such as a Palm® or micro-PC into the electronic circuitry and using this device's display unit as the visual interface between the equipment and its operator.
- a commercially available hand-held computing device such as a Palm® or micro-PC
- the hand-held computer could be detached from the read-out unit and linked to a standard desktop computer. The information from the device could thus be downloaded into any of several commercially available data acquisition software programs for more detailed analysis or for electronic transfer via hard media or the internet to a remote location.
- the present invention provides for an impedance system and method of determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor.
- the system includes a loop antenna, which is coupled to an impedance analyzer.
- the impedance analyzer applies a constant voltage signal to the loop antenna scanning the frequency across a predetermined spectrum.
- the current passing through the transmitting antenna experiences a peak at the resonant frequency of the sensor.
- the resonant frequency and bandwidth are thus determined from this peak in the current.
- the method of determining the resonant frequency and bandwidth using an impedance approach may include the steps of transmitting an excitation signal using a transmitting antenna and electromagnetically coupling a sensor having a resonant circuit to the transmitting antenna thereby modifying the impedance of the transmitting antenna. Next, the step of measuring the change in impedance of the transmitting antenna is performed, and finally, the resonant frequency and bandwidth of the sensor circuit are determined.
- the present invention provides for a transmit and receive system and method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor.
- an excitation signal of white noise or predetermined multiple frequencies is transmitted from a transmitting antenna, the sensor being electromagnetically coupled to the transmitting antenna.
- a current is induced in the resonant circuit of the sensor as it absorbs energy from the transmitted excitation signal, the current oscillating at the resonant frequency of the resonant circuit.
- a receiving antenna also electromagnetically coupled to the transmitting antenna, receives the excitation signal minus the energy which was absorbed by the sensor.
- the power of the received signal experiences a dip or notch at the resonant frequency of the sensor.
- the resonant frequency and bandwidth are determined from this notch in the power.
- the transmit and receive method of determining the resonant frequency and bandwidth of a sensor circuit includes the steps of transmitting a multiple frequency signal from transmitting antenna, and, electromagnetically coupling a resonant circuit on a sensor to the transmitting antenna thereby inducing a current in the sensor circuit. Next, the step of receiving a modified transmitted signal due to the induction of current in the sensor circuit is performed. Finally, the step of determining the resonant frequency and bandwidth from the received signal is executed.
- Yet another system and method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor includes a chirp interrogation system.
- This system provides for a transmitting antenna which is electromagnetically coupled to the resonant circuit of the sensor.
- An excitation signal of white noise or predetermined multiple frequencies, or a time-gated single frequency is applied to the transmitting antenna for a predetermined period of time, thereby inducing a current in the resonant circuit of the sensor at the resonant frequency.
- the system listens for a return signal which is coupled back from the sensor.
- the resonant frequency and bandwidth of the resonant circuit are determined from the return signal.
- the chirp interrogation method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor includes the steps of transmitting a multi-frequency signal pulse from a transmitting antenna, electromagnetically coupling a resonant circuit on a sensor to the transmitting antenna thereby inducing a current in the sensor circuit, listening for and receiving a return signal radiated from the sensor circuit, and determining the resonant frequency and bandwidth from the return signal.
- the present invention also provides an analog system and method for determining the resonant frequency of a resonant circuit within a particular sensor.
- the analog system comprises a transmitting antenna coupled as part of a tank circuit which in turn is coupled to an oscillator.
- a signal is generated which oscillates at a frequency determined by the electrical characteristics of the tank circuit.
- the frequency of this signal is further modified by the electromagnetic coupling of the resonant circuit of a sensor.
- This signal is applied to a frequency discriminator which in turn provides a signal from which the resonant frequency of the sensor circuit is determined.
- the analog method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor includes the steps of generating a transmission signal using a tank circuit which includes a transmitting antenna, modifying the frequency of the transmission signal by electromagnetically coupling the resonant circuit of a sensor to the transmitting antenna, and converting the modified transmission signal into a standard signal for further application.
- the invention further includes an alternative method of measuring pressure in which a non-linear element such as a diode or polyvinylidenedifloride piezo-electric polymer is added to the LC circuit.
- a non-linear element such as a diode or polyvinylidenedifloride piezo-electric polymer is added to the LC circuit.
- a diode with a low turn-on voltage such as a Schottky diode can be fabricated using micro-machining techniques.
- the presence of this non-linear element in various configurations within the LC circuit can be used to modulate the incoming signal from the receiving device and produce different harmonics of the original signal.
- the read-out circuitry can be tuned to receive the particular harmonic frequency that is produced and use this signal to reconstruct the fundamental frequency of the sensor.
- the advantage of this approach is two-fold; the incoming signal can be transmitted continuously and since the return signal will be at different signals, the return signal can also be received continuously.
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Abstract
Description
- This application is based upon co-pending, commonly assigned U.S. provisional patent application Ser. No. 60/503,745, filed Sep. 16, 2003, incorporated herein by reference in its entirety.
- The application is directed to an implantable wireless sensor. More particularly, this invention is directed to a wireless, unpowered, micromechanical sensor that can be delivered using endovascular techniques, to measure a corporeal parameter such as pressure or temperature.
- Abdominal aortic aneurysms represent a dilatation and weakening of the abdominal aorta which can lead to aortic rupture and sudden death. Previously, the medical treatment of abdominal aortic aneurysms required complicated surgery with an associated high risk of injury to the patient. More recently, endografts (combining stents and grafts into a single device) have been developed that can be inserted through small incisions in the groin. Once in place, these endografts seal off the weakened section of the aorta. The aneurysms can then heal, eliminating the risk of sudden rupture. This less invasive form of treatment for abdominal aortic aneurysms has rapidly become the standard of care for this disease. An example of an endograft device is disclosed in Kornberg, U.S. Pat. No. 4,617,932.
- A significant problem with endografts is that, due to inadequate sealing of the graft with the aorta, leaks can develop that allow blood to continue to fill the aneurysmal sac. Left undiscovered, the sac will continue to expand and potentially rupture. To address this situation, patients who have received endograft treatment for their abdominal aortic aneurysms are subjected to complex procedures that rely on injection of contrast agents to visualize the interior of the aneurysm sac. These procedures are expensive, not sensitive, and painful. In addition, they subject the patient to additional risk of injury. See, for example, Baum R A et al., “Aneurysm sac pressure measurements after endovascular repair of abdominal aortic aneurysms”, The Journal of Vascular Surgery, January 2001, and Schurink G W et al., “Endoleakage after stent-graft treatment of abdominal aneurysm: implications on pressure and imaging—an in vitro study”, The Journal of Vascular Surgery, August 1998. These articles provide further confirmation of the problem of endograft leakage and the value of intra-sac pressure measurements for monitoring of this condition.
- Thus, there is a need for a method of monitor the pressure within an aneurysm sac that has undergone repair by implantation of an endograft to be able to identify the potential presence of endoleaks. Furthermore, this method should be accurate, reliable, safe, simple to use, inexpensive to manufacture, convenient to implant and comfortable to the patient.
- An ideal method of accomplishing all of the above objectives would be to place a device capable of measuring pressure within the aneurysm sac at the time of endograft insertion. By utilizing an external device to display the pressure being measured by the sensor, the physician will obtain an immediate assessment of the success of the endograft at time of the procedure, and outpatient follow-up visits will allow simple monitoring of the success of the endograft implantation.
- An example of an implantable pressure sensor designed to monitor pressure increases within an aneurysmal sac is shown in Van Bockel, U.S. Pat. No. 6,159,156. While some of the above objectives are accomplished, this device has multiple problems that would make its use impractical. For example, the sensor system disclosed in the Van Bockel patent relies on a mechanical sensing element that cannot be practically manufactured in dimensions that would allow for endovascular introduction. In addition, this type of pressure sensor would be subject to many problems in use that would limit its accuracy, stability and reliability. One example would be the interconnection of transponder and sensor as taught by Van Bockel, such interconnection being exposed to body fluids which could disrupt its function. This would impact the device's ability to maintain accurate pressure reading over long periods of time. A fundamental problem with sensors is their tendency to drift over time. A sensor described in the Van Bockel patent would be subject to drift as a result of its failure to seal the pressure sensing circuit from the external environment. Also, by failing to take advantage of specific approaches to electronic component fabrication, allowing for extensive miniaturization, the Van Bockel device requires a complex system for acquiring data from the sensor necessary for the physician to make an accurate determination of intra-aneurysmal pressure.
- It is an object of this invention to provide an implantable wireless sensor.
- It is also an object of this invention to provide a wireless, unpowered, micromechanical sensor that can be delivered endovascularly.
- It is a further object of this invention to provide an implantable, wireless, unpowered sensor that can be delivered endovascularly to measure pressure and/or temperature.
- It is a yet further object of this invention to provide a method of preparing a micromechanical implantable sensor.
- It is a yet further object of this invention to provide a micromechanical sensor with a hermetically sealed, unbreached pressure reference for enhanced stability.
- These and other objects of the invention will become more apparent from the discussion below.
- The present invention comprises a device that can be implanted into the human body using non-surgical techniques to measure a corporeal parameter such as pressure, temperature, or both. Specific target locations could include the interior of an abdominal aneurysm or a chamber of the heart. This sensor is fabricated using MicroElectroMechanical Systems (MEMS) technology, which allows the creation of a device that is small, accurate, precise, durable, robust, biocompatible, radiopaque and insensitive to changes in body chemistry, biology or external pressure. This device will not require the use of wires to relay pressure information externally nor need an internal power supply to perform its function.
- The MEMS approach to sensor design lends itself to the fabrication of small sensors that can be formed using biocompatible materials as substrate materials. The pressure sensor described above can be introduced into the sac of an abdominal aneurysm at the time an endograft is deployed within the aorta by using standard endovascular catheter techniques. Appropriately biocompatible coatings may be applied to the surface of the sensor to prevent adhesion of biological substances or coagulated blood to the sensor that could interfere with its proper function.
- In one embodiment of the invention an implantable wireless sensor comprises two substrates, at least one of which has a recess. The sensor comprises a self-contained resonant circuit comprising a capacitor and an inductor, where the circuit is variable in response to a physical property, or changes in a physical property, of a patient. The substrates are sealed together to form a hermetically scaled chamber, preferably one that is pressure sensitive.
- In another embodiment of the invention one surface of each substrate comprises an inductor coil such as a wire spiral arranged in planar fashion. When the substrates are sealed together, the wire spirals are in planes parallel to each other.
- In another embodiment of the invention each inductor coil is connected by a wire to a capacitor plate arranged in the middle of the respective coil. The capacitor plates are substantially planar to the respective inductor coils and are substantially arranged parallel to each other.
- In another embodiment of the invention the sensor may comprise a metallic basket arranged exterior to the substrates.
- Delivery of the device of the invention to an aneurysm may be accomplished as follows: Using the standard Seldinger technique, the physician gains access to the patient's femoral artery and places a vessel introducer with a hemostatic valve. Under direct fluoroscopic visualization, a flexible guidewire is inserted through the introducer catheter and maneuvered such that its tip is stationed within the sac of the aortic aneurysm. A standard vessel introducer is inserted over the guidewire and through the introducer and advanced distally until its tip is within the aneurysmal sac. The inner dilator of the vessel introducer is removed and a sensor delivery vehicle is inserted the inner lumen of introducer. The delivery vehicle consists of a polymer support tube with two channels that run through its length, a metal or rigid sensor support capsule in which the sensor is placed and atraumatic tip.
- The sensor is attached to a tethering system consisting of a hollow tube with small diameter flexible wire disposed within. Near the terminal end of the hollow tube, a small break in the tube's surface is made. The flexible tether wire emerges out of this break, is threaded through a small hole in the rear section of the sensor, placed over the sensor, inserted through an identical hole in the forward segment of the sensor and re-inserted back into the hollow tube in a similar break in the tube's surface. In this configuration, the sensor remains secured to the tether wire after the delivery vehicle is removed from the patient. Following the insertion and deployment of the stent-graft, the sensor is detached from the tether wire by simply retracting the wire from the hollow tube. Once the wire has been pulled through the two holes in the sensor, the sensor is released into the aneurysm sac and the wire and hollow tube are removed.
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FIG. 1 is an oblique perspective view of an embodiment of the invention; -
FIG. 2 is a top, partly cross-sectional view of the embodiment of the invention shown inFIG. 1 ; -
FIG. 3 is a top, partly cross-sectional view of another embodiment of the invention; -
FIG. 4 is an oblique, cross-sectional view of the embodiment of the invention shown inFIG. 2 ; -
FIG. 5 is an oblique, cross-sectional view of the embodiment of the invention shown inFIG. 3 ; -
FIG. 6 is a exposed cross-sectional view of the embodiment of the invention shown inFIG. 5 ; -
FIG. 7 shows part of the sensor tethering system; -
FIG. 8 shows the further details of the tethering system; - FIGS. 9 to 12 show additional details of the tethering system;
- FIGS. 13 to 15 show details of the delivery system;
- FIGS. 16 to 26 show details of the manufacturing process used to fabricate the invention;
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FIG. 27 represents an additional embodiment of the invention; and -
FIG. 28 is a schematic of a control system. - The invention can perhaps be better understood by referring to the drawings.
FIG. 1 is an oblique, perspective view of asensor 2, an embodiment of the invention.Sensor 2 preferably has an outer coating of biocompatible silicone. -
FIG. 2 is a top, partial cross-section of a schematic representation ofsensor 2 where a wirespiral inductor coil 4 is positioned in planar fashion in asubstrate 6.Optionally sensor 2 may haverecesses 8, each with ahole 10, to receive a tether wire (not shown here) for delivery of the device into a human patient, as described below. - In the embodiment of the invention shown in
FIG. 3 , awire 12 connectscoil 4 to acapacitor plate 14 positioned withincoil 4. -
FIG. 4 is a slightly oblique cross-section across its width of the embodiment of the invention shown inFIG. 2 , where it can be seen thatsensor 2 is comprised of alower substrate 20 and anupper substrate 22.Lower substrate 20 andupper substrate 22 are constructed from a suitable material, such as glass, fused silica, sapphire, quartz, or silicon. Fused silica is the preferred material of construction.Lower substrate 20 has on itsupper surface 24 aninduction coil 26, andupper substrate 22 has arecess 28 with asurface 30 having aninduction coil 32 thereon. The top surface ofupper substrate 22 forms amembrane 34 capable of mechanically responding to changes in a patient's physical property, such as pressure. Theend 36 ofsensor 2 has a notch orrecess 38. - In similar fashion,
FIG. 5 is a slightly oblique cross-section across its width of the embodiment of the invention shown inFIG. 3 . The primary difference betweenFIGS. 4 and 5 is the presence ofupper capacitor plate 42 andlower capacitor plate 44 onsurfaces FIG. 4 , thespiral coil 4 itself acts as the capacitive element of the LC circuit that describes the operation of the sensor. -
FIG. 6 is a variation ofFIG. 5 where the outline ofupper substrate 22 is shown but the details oflower substrate 20 can be seen more clearly, including individual coils ofinductor coil 26. A wire 46 connectslower capacitor plate 44 toinduction coil 26. - The size of the sensors of the invention will vary according to factors such as the intended application, the delivery system, etc. The oval sensors are intended to be from about 0.5 in. to about 1 in. in length and from about 0.1 in. to about 0.5 in. in width, with a thickness of from about 0.05 in. to about 0.30 in.
- As shown in
FIGS. 4 and 5 ,upper substrate 22 can be significantly thinner thanlower substrate 20. By way of example,upper substrate 22 may be from about 100 to about 300 microns thick, whereaslower substrate 20 may be from about 500 to about 1500 microns thick. In an alternate embodiment of the invention, both substrates may be of the same thickness ranging from about 100 to about 1000 microns. - In the embodiment of the invention shown in
FIG. 7 , asensor 50 is attached to ahollow tube 52 that has aflexible tip 54. -
FIG. 8 shows thesensor 50 and specific features of the tethering system, namelyproximal holes 56 anddistal holes 58 disposed in ahollow tube 52. -
FIG. 9 shows atether wire 60 that is attached tosensor 50 at sensor holes 62 and hollow tube holes 56 and 58, and atether wire 60 is positioned slidably within ahollow tube 52. - A better appreciation of certain aspects of the invention, especially of a delivery system, can be obtained from
FIG. 10 which shows avessel introducer 66 and thedelivery system 68. - Further details of the delivery system are shown in
FIG. 11 . Adouble lumen tube 70 has one channel that accepts aguidewire 72 and a second channel that accepts the sensor tether wire. Theguidewire 72 can be advanced throughhub 74. Arigid delivery capsule 78 is disposed at the far end of the delivery catheter andflexible tip 80 is connected to the catheter via ahollow tube 81 extending through thedelivery capsule 78. Asensor 82 is positioned inside a slot in thedelivery capsule 78 proximal toflexible tip 80. -
FIG. 12 shows a lateral, cross-sectional view of this arrangement where thesensor 82 is inside the slot ofdelivery capsule 78 and theflexible tip 84 of the tether wire is disposed between the end ofdelivery capsule 78 andflexible tip 80. -
FIG. 13 showsdelivery catheter 68 loaded into the previously placedvessel introducer 66 prior to introduction of the sensor into the body. -
FIG. 14 shows that thesensor 82 ontether tube 52 has been advanced out ofdelivery capsule 78 and the delivery catheter has been removed. - In
FIG. 15 , the tether wire has been retracted into the hollow tether tube, releasing the sensor. The tether wire, tether tube andvessel introducer 66 are then all removed. - The pressure sensor of the invention can be manufactured using Micro-machining techniques that were developed for the integrated circuit industry. An example of this type of sensor features an inductive-capacitive (LC) resonant circuit with a variable capacitor, as is described in Allen et al., U.S. Pat. Nos. 6,111,520 and 6,278,379, all of which are incorporated herein by reference. The sensor contains two types of passive electrical components, namely, an inductor and a capacitor. The sensor is constructed so that the fluid pressure at the sensor's surface changes the distance between the capacitor's substantially parallel plates and causes a variation of the sensor's capacitance.
- In a preferred embodiment the sensor of the invention is constructed through a series of steps that use standard MEMS manufacturing techniques.
-
FIG. 16 shows the first step of this process in which a thin layer of metal (Protective mask) 90 is deposited onto the top and bottom surface of a fused silica wafer 92 (alternative materials would be glass, quartz, silicon or ceramic). Wafer diameters can range from about 3 to about 6 in. Wafer thickness can range from about 100 to about 1500 microns. A pattern mask is then created on one side of the wafer to define the location of cavities that need to be etched into the surface. -
FIG. 17 shows trenches orcavities 94 are etched into one surface of thewafer 92 to depths ranging from about 20 to about 200 microns. This etching is accomplished using any combination of standard wet and dry etching techniques (acid etch, plasma etch, reactive ion etching) that are well known in the MEMS industry. The protective metal mask is removed using standard metal etching techniques. - In
FIG. 18 , a thin metal seed layer 96 (typically chromium) is deposited on the etched side of the wafer using standard metal deposition techniques such as sputtering, plating or metal evaporation. - In
FIG. 19 a layer of photo-resistive material 98 is applied to the etched surface of the wafer using standard spin coating procedures. -
FIG. 20 shows that a mask aligner andUV light 102 is used in a photolithographic processes to transfer a pattern from amask 104 to the photoresist coating on the wafer. - In
FIG. 21 , the non-masked portions of the Photoresist are removed chemically creating amold 106 of the desired coil pattern. -
FIG. 22 showscopper 108 electroplated into the mold to the desired height, typically from about 5 to about 35 microns. - In
FIG. 23 , thePhotoresist 110 andseed layer 112 are etched away leaving the plated copper coils 114. - This process is then repeated with a second wafer.
- In
FIG. 24 , the two processedwafers cavities -
FIGS. 25 and 26 show that by using a CO2 laser 126 (or other appropriate laser type), theindividual sensors 130 are cut from the glass wafer. The laser cutting process results in a permanent, hermetic seal between the two glass wafers. The laser energy is confined to a preciseheat effect zone 128 in which the hermetic seal is created. -
FIG. 27 represents an embodiment of the invention wherein a sensor 132 attached to a delivery catheter 134 has a stabilizer or basket 136. The stabilizer can be any appropriate device or structure that can be fixedly attached to a sensor of the invention to assist the sensor in maintaining position, location, and/or orientation after the sensor is delivered to an intended site. The stabilizer can comprise any appropriate physiologically acceptable rigid or slightly flexible material, such as stainless steel, nitinol, or a radiopaque metal or alloy. - This sensor design provides many important benefits to sensor performance. The hermetic seal created during the laser cutting process, coupled with the design feature that the conductor lines of the sensor are sealed within the hermetic cavity, allows the sensor to remain stable and drift free during long time exposures to body fluids. In the past, this has been a significant issue to the development of sensors designed for use in the human body. The manufacturing methodology described above allows many variations of sensor geometry and electrical properties. By varying the width of the coils, the number of turns and the gap between the upper and lower coils the resonant frequency that the device operates at and the pressure sensitivity (i.e., the change in frequency as a result of membrane deflection) can be optimized for different applications. In general, the design allows for a very small gap between the coils (typically between about 3 and about 35 microns) that in turn provides a high degree of sensitivity while requiring only a minute movement of the coils to sense pressure changes. This is important for long term durability, where large membrane deflection could result in mechanical fatigue of the pressure sensing element.
- The thickness of the sensor used can also be varied to alter mechanical properties. Thicker wafers are more durable for manufacturing. Thinner sensors allow for creating of thin pressure sensitive membranes for added sensitivity. In order to optimize both properties the sensors may be manufactured using wafers of different thicknesses. For example, one side of the sensor may be constructed from a sensor of approximate thickness of 200 microns. This wafer is manufactured using the steps outlined above. Following etching, the thickness of the pressure sensitive membrane (i.e., the bottom of the etched trench) is in the range of from about 85 to about 120 microns. The matching wafer is from about 500 to about 1000 microns thick. In this wafer, the trench etching step is eliminated and the coils are plated directly onto the flat surface of the wafer extending above the wafer surface a height of from about 20 to about 40 microns. When aligned and bonded, the appropriate gap between the top and bottom coils is created to allow operation preferably in a frequency range of from 30 to 45 MHz and have sensitivity preferably in the range of from 5 to 15 kHz per millimeter of mercury. Due to the presence of the from about 500 to about 1000 micron thick wafer, this sensor will have added durability for endovascular delivery and for use within the human body.
- The sensor exhibits the electrical characteristics associated with a standard LC circuit. An LC circuit can be described as a closed loop with two major elements, a capacitor and an inductor. If a current is induced in the LC loop, the energy in the circuit is shared back and forth between the inductor and capacitor. The result is an energy oscillation that will vary at a specific frequency. This is termed the resonant frequency of the circuit and it can be easily calculated as its value is dependent on the circuit's inductance and capacitance. Therefore, a change in capacitance will cause the frequency to shift higher or lower depending upon the change in the value of capacitance.
- As noted above, the capacitor in the assembled pressure sensor consists of the two circular conductive segments separated by an air gap. If a pressure force is exerted on these segments it will act to move the two conductive segments closer together. This will have the effect of reducing the air gap between them which will consequently change the capacitance of the circuit. The result will be a shift in the circuit's resonant frequency that will be in direct proportion to the force applied to the sensor's surface.
- Because of the presence of the inductor, it is possible to electromagnetically couple to the sensor and induce a current in the circuit. This allows for wireless communication with the sensor and the ability to operate it without the need for an internal source of energy such as a battery. Thus, if the sensor is located within the sac of an aortic aneurysm, it will be possible to determine the pressure within the sac in a simple, non-invasive procedure by remotely interrogating the sensor, recording the resonant frequency and converting this value to a pressure measurement. The readout device generates electromagnetic energy that penetrates through the body's tissues to the sensor's implanted location. The sensor's electrical components absorb a fraction of the electromagnetic energy that is generated by the readout device via inductive coupling. This coupling induces a current in the sensor's circuit that oscillates at the same frequency as the applied electromagnetic energy. Due to the nature of the sensor's electromechanical system there exists a frequency of alternating current at which the absorption of energy from the readout device is at a maximum. This frequency is a function of the capacitance of the device. Therefore, if the sensor's capacitance changes, so will the optimal frequency at which it absorbs energy from the readout device. Since the sensor's capacitance is mechanically linked to the fluid pressure at the sensor's surface, a measurement of this frequency by the readout device gives a relative measurement of the fluid pressure. If calibration of the device is performed, then an absolute measurement of pressure can be made. See, for example, the extensive discussion in the Allen et al. patent, again incorporated herein by reference, as well as Gershenfeld et al., U.S. Pat. No. 6,025,725, incorporated herein by reference. Alternative readout schemes, such as phase-correlation approaches to detect the resonant frequency of the sensor, may also be employed.
- The pressure sensor is made of completely passive components having no active circuitry or power sources such as batteries. The pressure sensor is completely self-contained having no leads to connect to an external circuit or power source. Furthermore, these same manufacturing techniques can be used to add additional sensing capabilities, such as the ability to measure temperature by the addition of a resistor to the basic LC circuit or by utilizing changes in the back pressure of gas intentionally sealed within the hermetic pressure reference to change the diaphragm position and therefore the capacitance of the LC circuit.
- It is within the scope of the invention that the frequency response to the sensor will be in the range of from about 1 to about 200 MHz, preferably from about 1 to about 100 MHz, and more preferably from about 2 to about 90 MHz, and even more preferably from about 30 to about 45 MHz, with a Q factor of from about 5 to about 150, optimally from about 5 to about 80, preferably from about 40 to about 100, more preferably from about 50 to about 90.
- In a further embodiment of the invention there is no direct conductor-based electrical connection between the two sides of the LC circuit. Referring again to the sensor described in the Allen et al. patents, the device is constructed using multiple layers upon lie the necessary circuit elements. Disposed on the top and bottom layer are metal patterns constructed using micro-machining techniques which define a top and bottom conductor and a spiral inductor coil. To provide for an electrical contact between the top and bottom layers small vias or holes are cut through the middle layers. When the layers are assembled, a metal paste is forced into the small vias to create direct electrical connections or conduits. However, experimentation has shown that due to additional capacitance that is created between the top and bottom inductor coils, a vialess operational LC circuit can be created. This absence of via holes represents a significant improvement to the sensor in that it simplifies the manufacturing process and, more importantly, significantly increases the durability of the sensor making it more appropriate for use inside the human body.
- Further, the invention is not limited to the implantation of a single sensor. Multiple pressure sensors may be introduced into the aneurysm space, each being positioned at different locations. In this situation, each sensor may be designed with a unique signature (obtained by changing the resonant frequency of the sensor), so that the pressure measurement derived from one sensor can be localized to its specific position within the aneurysm.
- A significant design factor that relates to the performance of the sensor and the operation of the system is the Quality factor (Q) associated with the sensor. The value of Q is one of the key determinates as to how far from the sensor the external read-out electronics can be located while still maintaining effective communication. Q is defined as a measure of the energy stored by the circuit divided by the energy dissipated by the circuit. Thus, the lower the loss of energy, the higher the Q.
- Additional increases in Q can be achieved by removing the central capacitive plate and using capacitive coupling between the copper coils to act as the capacitor element.
- In operation, energy transmitted from the external read-out electronics will be stored in the LC circuit of the sensor. This stored energy will induce a current in the LC loop which will cause the energy to be shared back and forth between the inductor and capacitor. The result is an oscillation that will vary at the resonant frequency of the LC circuit. A portion of this ocscillating energy is then coupled back to the receiving antenna of the read-out electronics. In high Q sensors, most of the stored energy is available for transmission back to the electronics, which allows the distance between the sensor and the receiving antenna to be increased. Since the transmitted energy will decay exponentially as it travels away from the sensor, the lower the energy available to be transmitted, the faster it will decay below a signal strength that can be detected by the receiving antenna and the closer the sensor needs to be situated relative to the receiving electronics. In general then, the lower the Q, the greater the energy loss and the shorter the distance between sensor and receiving antenna required for sensor detection.
- The Q of the sensor will be dependent on multiple factors such as the shape, size, diameter, number of turns, spacing between turns and cross-sectional area of the inductor component. In addition, Q will be greatly affected by the materials used to construct the sensors. Specifically, materials with low loss tangents will provide the sensor with higher Q factors.
- The implantable sensor ascending to the invention is preferably constructed of various glasses or ceramics including but not limited to fused silica, quartz, pyrex and sintered zirconia, that provide the required biocompatibility, hermeticity and processing capabilities. Preferably the materials result in a high Q factor. These materials are considered dielectrics, that is, they are poor conductors of electricity, but are efficient supporters of electrostatic or electroquasiatatic fields. An important property of dielectric materials is their ability to support such fields while dissipating minimal energy. The lower the dielectric loss (the proportion of energy lost), the more effective the dielectric material in maintaining high Q. For a lossy dielectric material, the loss is described by the property termed “loss tangent.” A large loss tangent reflects a high degree of dielectric loss.
- With regard to operation within the human body, there is a second important issue related to Q, namely, that blood and body fluids are conductive mediums and are thus particularly lossy. The consequence of this fact is that when a sensor is immersed in a conductive fluid, energy from the sensor will dissipate, substantially lowering the Q and reducing the sensor-to-electronics distance. For example, the sensors described above were immersed in saline (0.9% salt solution), and the measured Q decreased to approximately 10. It has been found that such loss can be minimized by further separation of the sensor from the conductive liquid. This can be accomplished, for example, by encapsulating the sensor in a suitable low-loss-tangent dielectric material. However, potential encapsulation material must have the flexibility and biocompatibility characteristics of the sensor material and also be sufficiently compliant to allow transmission of fluid pressure to the pressure sensitive diaphragm. A preferred material for this application is polydimethylsiloxane (silicone).
- As an example, a thin (i.e., 200 micron) coating of silicone was applied to the sensor detailed above. This coating provided sufficient insulation to maintain the Q at 50 in a conductive medium. Equally important, despite the presence of the silicone, adequate sensitivity to pressure changes was maintained and the sensor retained sufficient flexibility to be folded for endovascular delivery. One additional benefit of the silicone encapsulation material is that it can be optionally loaded with a low percentage (i.e., 10-20%) of radio-opaque material (e.g., barium sulfate) to provide visibility when examined using fluoroscopic x-ray equipment. This added barium sulfate will not affect the mechanical and electrical properties of the silicone.
- As described above, it is desirable to increase the Q factor of a sensor, and the Q factor can be increased by suitable selection of sensor materials or a coating, or both. Preferably both are used, because the resulting high Q factor of a sensor prepared in this fashion is especially suitable for the applications described.
- When introduced into the sac of an abdominal aorta, the pressure sensor can provide pressure related data by use of an external measuring device. As disclosed in the Allen et al. patents, several different excitation systems can be used. The readout device generates electromagnetic energy that can penetrate through the body's tissues to the sensor's implanted location. The sensor's electrical components can absorb a fraction of the electromagnetic energy that is generated by the readout device via inductive coupling. This coupling will induce a current in the sensor's circuit that will oscillate at the same frequency as the applied electromagnetic energy. Due to the nature of the sensor's electromechanical system there will exist a frequency of alternating current at which the absorption of energy from the readout device is at a minimum. This frequency is a function of the capacitance of the device. Therefore, if the sensor's capacitance changes so will the frequency at which it minimally absorbs energy from the readout device. Since the sensor's capacitance is mechanically linked to the fluid pressure at the sensor's surface, a measurement of this frequency by the readout device can give a relative measurement of the fluid pressure. If calibration of the device is performed then an absolute measurement of pressure can be made.
- The circuitry used to measure and display pressure is contained within a simple to operate, portable
electronic unit 400, as shown inFIG. 28 . Thisunit 400 also contains the antenna needed to perform the electromagnetic coupling to the sensor. The antenna may be integrated into the housing for the electronics or it may be detachable from the unit so that it can be positioned on the surface of thebody 402 in proximity to the implanted sensor and easily moved to optimize the coupling between antenna and sensor. The antenna itself may consist of a simple standard coil configuration or my incorporate ferrous elements to maximize the coupling efficiency. The electronic device would feature an LCD orLED display 404 designed to clearly display the recorded pressure in physiologically relevant units such as mm Hg. In an alternative embodiment, the display may be created by integrating a commercially available hand-held computing device such as a Palm® or micro-PC into the electronic circuitry and using this device's display unit as the visual interface between the equipment and its operator. A further advantage of this approach is that the hand-held computer could be detached from the read-out unit and linked to a standard desktop computer. The information from the device could thus be downloaded into any of several commercially available data acquisition software programs for more detailed analysis or for electronic transfer via hard media or the internet to a remote location. - Accordingly, the present invention provides for an impedance system and method of determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor. The system includes a loop antenna, which is coupled to an impedance analyzer. The impedance analyzer applies a constant voltage signal to the loop antenna scanning the frequency across a predetermined spectrum. The current passing through the transmitting antenna experiences a peak at the resonant frequency of the sensor. The resonant frequency and bandwidth are thus determined from this peak in the current.
- The method of determining the resonant frequency and bandwidth using an impedance approach may include the steps of transmitting an excitation signal using a transmitting antenna and electromagnetically coupling a sensor having a resonant circuit to the transmitting antenna thereby modifying the impedance of the transmitting antenna. Next, the step of measuring the change in impedance of the transmitting antenna is performed, and finally, the resonant frequency and bandwidth of the sensor circuit are determined.
- In addition, the present invention provides for a transmit and receive system and method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor. According to this method, an excitation signal of white noise or predetermined multiple frequencies is transmitted from a transmitting antenna, the sensor being electromagnetically coupled to the transmitting antenna. A current is induced in the resonant circuit of the sensor as it absorbs energy from the transmitted excitation signal, the current oscillating at the resonant frequency of the resonant circuit. A receiving antenna, also electromagnetically coupled to the transmitting antenna, receives the excitation signal minus the energy which was absorbed by the sensor. Thus, the power of the received signal experiences a dip or notch at the resonant frequency of the sensor. The resonant frequency and bandwidth are determined from this notch in the power.
- The transmit and receive method of determining the resonant frequency and bandwidth of a sensor circuit includes the steps of transmitting a multiple frequency signal from transmitting antenna, and, electromagnetically coupling a resonant circuit on a sensor to the transmitting antenna thereby inducing a current in the sensor circuit. Next, the step of receiving a modified transmitted signal due to the induction of current in the sensor circuit is performed. Finally, the step of determining the resonant frequency and bandwidth from the received signal is executed.
- Yet another system and method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor includes a chirp interrogation system. This system provides for a transmitting antenna which is electromagnetically coupled to the resonant circuit of the sensor. An excitation signal of white noise or predetermined multiple frequencies, or a time-gated single frequency is applied to the transmitting antenna for a predetermined period of time, thereby inducing a current in the resonant circuit of the sensor at the resonant frequency. The system then listens for a return signal which is coupled back from the sensor. The resonant frequency and bandwidth of the resonant circuit are determined from the return signal.
- The chirp interrogation method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor includes the steps of transmitting a multi-frequency signal pulse from a transmitting antenna, electromagnetically coupling a resonant circuit on a sensor to the transmitting antenna thereby inducing a current in the sensor circuit, listening for and receiving a return signal radiated from the sensor circuit, and determining the resonant frequency and bandwidth from the return signal.
- The present invention also provides an analog system and method for determining the resonant frequency of a resonant circuit within a particular sensor. The analog system comprises a transmitting antenna coupled as part of a tank circuit which in turn is coupled to an oscillator. A signal is generated which oscillates at a frequency determined by the electrical characteristics of the tank circuit. The frequency of this signal is further modified by the electromagnetic coupling of the resonant circuit of a sensor. This signal is applied to a frequency discriminator which in turn provides a signal from which the resonant frequency of the sensor circuit is determined.
- The analog method for determining the resonant frequency and bandwidth of a resonant circuit within a particular sensor includes the steps of generating a transmission signal using a tank circuit which includes a transmitting antenna, modifying the frequency of the transmission signal by electromagnetically coupling the resonant circuit of a sensor to the transmitting antenna, and converting the modified transmission signal into a standard signal for further application.
- The invention further includes an alternative method of measuring pressure in which a non-linear element such as a diode or polyvinylidenedifloride piezo-electric polymer is added to the LC circuit. A diode with a low turn-on voltage such as a Schottky diode can be fabricated using micro-machining techniques. The presence of this non-linear element in various configurations within the LC circuit can be used to modulate the incoming signal from the receiving device and produce different harmonics of the original signal. The read-out circuitry can be tuned to receive the particular harmonic frequency that is produced and use this signal to reconstruct the fundamental frequency of the sensor. The advantage of this approach is two-fold; the incoming signal can be transmitted continuously and since the return signal will be at different signals, the return signal can also be received continuously.
- The above methods lend themselves to the creation of small and simple to manufacture hand-held electronic devices that can be used without complication.
- The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention of the scope of the appended claims.
Claims (25)
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US12/416,916 US8278941B2 (en) | 2003-09-16 | 2009-04-01 | Strain monitoring system and apparatus |
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US12/509,053 US8870787B2 (en) | 2003-09-16 | 2009-07-24 | Ventricular shunt system and method |
US13/245,553 US8896324B2 (en) | 2003-09-16 | 2011-09-26 | System, apparatus, and method for in-vivo assessment of relative position of an implant |
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2008
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2009
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Also Published As
Publication number | Publication date |
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EP1677852A4 (en) | 2009-06-24 |
WO2005027998A3 (en) | 2006-09-21 |
AU2009201750A1 (en) | 2009-05-28 |
US20060235310A1 (en) | 2006-10-19 |
US9265428B2 (en) | 2016-02-23 |
AU2009201749A1 (en) | 2009-05-28 |
WO2005027998A2 (en) | 2005-03-31 |
AU2004274005A1 (en) | 2005-03-31 |
CA2539261C (en) | 2011-05-17 |
US7574792B2 (en) | 2009-08-18 |
EP1677852A2 (en) | 2006-07-12 |
US20090030291A1 (en) | 2009-01-29 |
CA2539261A1 (en) | 2005-03-31 |
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