US20050010176A1 - Pressure actuated flow control valve - Google Patents

Pressure actuated flow control valve Download PDF

Info

Publication number
US20050010176A1
US20050010176A1 US10/892,762 US89276204A US2005010176A1 US 20050010176 A1 US20050010176 A1 US 20050010176A1 US 89276204 A US89276204 A US 89276204A US 2005010176 A1 US2005010176 A1 US 2005010176A1
Authority
US
United States
Prior art keywords
slit
flow
pressure
central wall
control valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/892,762
Inventor
W. Dikeman
Keny Spiker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dikeman W Cary
Original Assignee
Dikeman W. Cary
Keny Spiker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/304,833 priority Critical patent/US7601141B2/en
Priority to CA 2452309 priority patent/CA2452309C/en
Application filed by Dikeman W. Cary, Keny Spiker filed Critical Dikeman W. Cary
Priority to US10/892,762 priority patent/US20050010176A1/en
Publication of US20050010176A1 publication Critical patent/US20050010176A1/en
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • A61M2039/242Check- or non-return valves designed to open when a predetermined pressure or flow rate has been reached, e.g. check valve actuated by fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • A61M2039/2426Slit valve
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M39/1011Locking means for securing connection; Additional tamper safeties

Abstract

A pressure actuated flow control valve for an infusion catheter permits gravity flow of a liquid through the catheter and into a patient while resisting back flow of blood from the patient and into the catheter. The valve has a hemispherical body with an outstanding circumferential flange and a normally closed, diametric slit. The slit is longer on the convex outer surface than on the concave inner surface. Dome thickness diminishes in the area adjacent the slit, reducing total apical deflection upon collapse of the slit toward the concave surface. An inner orthogonal rib biases the slit closed. Upon application of a predetermined pressure, the slit opens toward the concave surface to permit forward fluid flow. At lower pressures, the slit closes to check fluid flow. Greater reverse pressure is required to collapse the slit toward the concave surface to permit reverse fluid flow.

Description

    CROSS REFERENCE(S)
  • This application is a continuation-in-part application of U.S. application Ser. No. 10/304,833 filed Nov. 26, 2002
  • BACKGROUND OF THE INVENTION
  • 1. Field of Invention
  • The present invention is broadly concerned with a control valve for a medical fluid infusion device. More particularly, it is concerned with a positive pressure actuated flow control valve that permits flow of a liquid from a reservoir, through a cannula and into a patient, while resisting reflux.
  • 2. Background Art
  • Medical infusion therapy employs peripheral and central intravascular devices such as venous and arterial catheters as well as peripherally inserted central venous catheters to deliver fluids, blood products, and pharmaceuticals, including antibiotics and biologics as well as parenteral nutrition. Intravascular devices may also be coupled with pressure monitoring systems.
  • Regardless of the location of the insertion site of the catheter or the placement of its terminus, intravascular devices, and central venous catheters (CVCs) in particular, are subject to retrograde blood flow into the catheter lumen whenever the pressure in the patient's vascular system exceeds resistance at the supply end of the catheter. This may occur, for example, when fluid pressure drops because a gravity supply source is empty, when an injection port is opened by removal of a syringe, or when a stopcock is opened.
  • Retrograde blood flow is known to contribute to complications such as catheter-related septicemia, venous thrombosis, superior vena cava syndrome, pulmonary embolism and phlebitis. Thrombus formation may cause partial or complete occlusion of the catheter. Partial occlusion results in impaired sampling and fluid administration. Complete occlusion causes the catheter to lose patency, necessitating removal and replacement, so-called “unscheduled restarts”.
  • Catheter reflux induced thrombosis is not merely a mechanical complication, since it appears to be a major contributor to catheter related bloodstream infections associated with the use of long term catheters. Such infections are associated with increased morbidity and mortality as well as increased health care costs associated with extended hospitalization.
  • Attempts have been made to develop improved intravascular devices in order to address the mechanical and infectious complications previously described. Peripherally inserted central venous catheters (PICC) are known to reduce the incidence of thrombosis and phlebitis as well as commonly reported central catheter-related infections. However, PICC devices are not suitable for all applications, particularly where the solution to be administered has high osmolarity or may be a pH irritant. And patients with PICC infusion still experience thrombus formation and phlebitis at statistically significant levels.
  • Guidewire assisted exchange has also been employed to achieve a lower rate of mechanical complications following insertion of replacement catheters. However, patients may experience bleeding, hydrothorax and subsequent catheter related infections.
  • In-line filters have also been employed to reduce infusion-related phlebitis. However, they have not been found to prevent intravascular device-related infections. And use of such filters is not regarded as mechanically favorable, since solution filtration may be accomplished more efficiently prior to infusion and the filters themselves are subject to blockage.
  • Impregnated catheters and needle-free devices have also been employed. Although they have not yet been thoroughly evaluated, antimicrobial coated or impregnated catheters appear to be more effective for central venous use than for peripheral use. There are concerns, however, that they may foster development of resistant bloodstream pathogens. Needle-free infusion systems also have not yet been fully studied, although one investigation has shown survival of skin flora in needleless infusion systems.
  • There have also been attempts to develop methods of using conventional intravascular devices in order to prevent catheter-related thrombus formation and to maintain catheter patency. Turbulent positive pressure flushing with anticoagulant heparin solution, use of thrombolytic agents such as urokinase, streptokinase and t-Pa, and prophylactic warfarin administration have all been employed.
  • However, some in vitro studies have suggested that heparin flush solutions may serve to enhance growth of Coagulase-negative staphylococci (CoNS). The United States Public Health Service, Centers for Disease Control and Prevention (CDC) has cited CoNS as “the primary pathogen causing catheter-related infections. It has recommended clinical trials to evaluate the practice of flushing with anticoagulant solutions to prevent catheter-related infections. The CDC has also cited an association between use of low dose heparin and thrombocytopenia and thromboembolic and hemorrhagic complications.
  • All of the preventive methods that are currently available appear to contribute in some manner to general health care delivery problems, such as delay, increased requirements for nursing care, pharmaceutical and supply costs, increased patient risk and discomfort.
  • Accordingly, there is a need for an improved intravascular device that will resist retrograde blood flow and thereby reduce rates of thrombus formation, catheter-related blood stream infection, and unscheduled restarts and thereby extend catheter indwelling times.
  • SUMMARY OF THE INVENTION
  • The present invention is directed to a pressure actuated flow control valve for an infusion catheter which permits gravity flow of a liquid through the catheter and into a patient while resisting back flow of blood from the patient and into the catheter. The valve is a flexible unitary body having a central wall that defines a fluid passageway portal. The valve includes a central wall, which in one embodiment is a hemispherical dome-shaped body having concave inner and convex outer surfaces. However, dome-shaped as utilized herein does not necessarily mean that the concave inner and the convex outer surfaces are spherical or substantially spherical. Dome-shaped simply refers to the concave and convex nature of the surfaces in that they have an arcuate cross-section but not necessarily circular. A normally closed opening communicates between the surfaces. The opening, normally identified as a slit, can extend along a diameter of the central wall and is configured so that it is longer on the convex outer surface than on the concave inner surface. The term slit is utilized to refer to a narrow elongated opening or cut such that the side walls formed by the opening are in contact with each other or are in near contact. The slit does not have to be continuous, although it is continuous in a preferred embodiment. The slit need not be straight but can have curvatures or angles. The contact or near contact of the side walls can be referred to as the normally closed or relaxed state or position. The cross-sectional thickness of the dome diminishes in the area adjacent the slit, reducing total apical deflection upon collapse of the slit toward the concave surface. The dome inner surface includes an orthogonal rib that biases the wall of the dome adjacent the slit to a closed position, for another embodiment the rib can be raised and elongated. Upon application of a predetermined pressure, the slit opens toward the convex surface for facilitating fluid flow in the intended direction. At lower pressures, the slit resumes a closed position to check fluid flow. Relatively greater reverse pressure is required to collapse the slit toward the concave surface to permit reverse fluid flow. The valve includes an outstanding circumferential flange for engagement within a housing.
  • Objects and advantages of this invention will become apparent from the following description taken in conjunction with the accompanying drawings wherein are set forth, by way of illustration and example, certain embodiments of this invention.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a combination diagrammatic and perspective, partially exploded view of a flow control valve assembly in accordance with the invention, installed in a medical fluid infusion system.
  • FIG. 2 is an enlarged sectional view taken along line 2-2 of FIG. 1 and shows details of the housing construction.
  • FIG. 3 is a front perspective view of the valve depicted in FIG. 1.
  • FIG. 4 is an enlarged bottom plan view of the valve depicted in FIG. 1.
  • FIG. 5 is an enlarged top plan view of the valve depicted in FIG. 1, showing the rib in phantom.
  • FIG. 6 is a further enlarged sectional view taken along line 6-6 of FIG. 4 and shows details of the valve slit.
  • FIG. 7 is a still further enlarged sectional view taken along line 7-7 of FIG. 4 and shows details of the rib.
  • FIG. 8 is a fragmentary sectional view similar to the view shown in FIG. 2 at a reduced scale, showing the valve in an open, forward fluid flow enabling position.
  • FIG. 9 is similar to the view depicted in FIG. 8, showing the valve in a collapsed, reverse fluid flow enabling position.
  • FIG. 10 is an enlarged sectional view of a valve assembly incorporating an alternate threaded Luer housing.
  • FIG. 11 is an enlarged bottom plan view of an alternate valve having a cylindrical rib configuration.
  • FIG. 12 is an enlarged sectional view taken along line 12-12 of FIG. 11 and shows details of the valve slit.
  • FIG. 13 is an enlarged bottom plan view of a second alternate valve having a cruciform rib configuration.
  • FIG. 14 is an enlarged sectional view taken along line 14-14 of FIG. 13 and showing details of the rib.
  • The drawings constitute a part of this specification and include exemplary embodiments of the present invention and illustrate various objects and features thereof.
  • DETAILED DESCRIPTION OF THE INVENTION
  • As required, detailed embodiments of the present invention are disclosed herein; however, it is to be understood that the disclosed embodiments are merely exemplary of the invention, which may be embodied in various forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present invention in virtually any appropriately detailed structure.
  • Certain terminology will be used in the following description for convenience in reference only and will not be limiting. For example, the words “distally” and “proximally” will refer to directions respectively toward and away from a patient.
  • Referring now to the drawings, a pressure actuated flow control valve assembly in accordance with the invention is generally indicated by the reference numeral 10 and is depicted in FIGS. 1 and 2. FIG. 1 illustrates exemplary use of the valve assembly 10 installed in-line between an intravascular device 12 such as an intravenous (IV) fluid delivery catheter set and an intravascular fluid source 14, such as an IV fluid reservoir. Those skilled in the art will appreciate that the pressure actuated valve assembly 10 can also be used in conjunction with a variety of other medical fluid delivery devices, such as an arterial catheter and associated chemotherapy fluid reservoir and/or pressure monitoring device, or a gastrostomy tube set having a corresponding fluid reservoir.
  • The intravascular device 12 includes an elongate, flexible catheter 16 having an outer surface and an inner surface defining a lumen or fluid passageway 18. A distal end of the catheter 16 is adapted for insertion into a vein of a patient. The outer surface of the proximal end of the catheter 16 is over molded by a compression strain relief cuff 20 and is coupled with a Y-connector 22, which serves as a manifold for coupling a pair of connector tubes 24 in fluidic communication with the single catheter 16. Each connector tube 24 has an outer surface and an inner surface defining a lumen 26, and proximal and distal end portions 28 and 30 respectively. The proximal end portions 28 are each over molded by a compression strain relief cuff 32. The Y-connector 22 receives the distal end portions 30. While FIG. 1 depicts an intravascular device 12 having two connector tubes 24, it is foreseen that any operable number of such tubes may be employed, including a single tube. In addition, while FIG. 1 depicts only the distal end of the catheter 16 as indwelling, the entire intravascular device 12 may be constructed for indwelling installation and use.
  • As more fully described herein, each connector tube proximal end portion 28 is coupled with a valve assembly 10, which in turn is coupled with a connector 34. The connector 34 has a generally cylindrical overall shape and is hollow and open at one end to receive the valve assembly 10. The connector 34 includes a threaded interior surface 36 and an exterior surface 38 that is swaged or flanged to facilitate gripping. One end of the connector 34 is axially apertured to permit coupling with a supply tube 40 having an outer surface and an inner surface defining a fluid passageway or lumen 42. The outer surface of the supply tube 40 adjacent the connector 34 is equipped with a molded fitment 44 to accommodate tubing attachment. The proximal end of the supply tube 40 is coupled with the fluid reservoir 14 so that the lumen 42 is in fluidic communication with the reservoir 14.
  • Although not shown in FIG. 1, the connector 34 may also be equipped with a stopcock or a plurality of infusion ports with plugs for receiving a syringe and/or needle. A pump may be installed in line with the supply tube 40, which may also be equipped with clamps (neither is shown).
  • The catheter 16, connector tubes 24 and supply tube 40 are flexible and pliant to facilitate placement, usage, and to minimize both mechanical insult to the blood vessels and patient discomfort during long-term use. They may be constructed of any suitable medical grade material, such as, for example, polyethylene, polyvinyl chloride, Teflon, silicone elastomer or polyurethane or mixtures thereof. The material may be coated or impregnated with an antimicrobial or antiseptic composition to reduce bacterial adherence and biofilm formation. The catheter 16 may also be constructed of a radiopaque material in order to facilitate imaging for locating any breaks and/or separated sections.
  • The strain relief cuffs 20 and 32 and fitment 44 are constructed of an elastomeric medical grade synthetic resin material. The connector 34 may be constructed of a medical grade rigid or semirigid synthetic resinous material suitable for supporting an operable threaded connection, such as, for example, polyvinyl chloride or polycarbonate.
  • As best shown in FIGS. 1 and 2, the valve assembly 10 broadly includes a housing 46 supporting a valve member 48. The housing 46 has an elongate, stepped external configuration surrounding an internal fluid passageway or lumen 50. The lumen 50 has an enlarged diameter adjacent the proximal end to form a hemispherical cavity 52 sized for receiving the dome-shaped valve 48. The housing 46 includes a hub portion 54, which is shown positioned for installation in a proximal orientation and a body portion 56 shown in a distal orientation. The housing 46 is formed of a suitable medical grade synthetic resin, such as for example, a polycarbonate.
  • The body 56 includes a tapered nipple 58 sized for reception within the lumen 26 of a connector tube 24. The nipple 58 includes a plurality of spaced, radially expanded annular barbs 60. While FIG. 1 depicts two barbs 60 evenly spaced along the nipple 58, it is foreseen that any number of barbs 60 may be included with any suitable degree of radial expansion and in any spaced configuration.
  • The proximal end of the nipple 58 is radially expanded to form a midportion or barrel 62, having a pair of opposed axial flanges or finger tabs 64 to facilitate manual rotation of the valve assembly 10. The barrel 62 is radially expanded at the proximal end to form an annular seat 66 for receiving the hub 54. The seat 66 includes a series of concentric steps 68 perpendicular to the axis of the lumen 50, each step 68 presenting a concentric side wall 70, which is coaxial with the lumen 50. The proximal step 68 serves as a valve seat 72. The surface of the valve seat 72 includes a raised annular ring or stake 74, having an angular or pointed, proximal surface adapted for gripping engagement of a valve 48.
  • The hub 54 has a hollow, stepped cylindrical configuration, including a distal skirt portion 76 and a proximal neck 78 with a central lumen 80. The inner surface of the skirt includes a series of concentric steps 82, each including a concentric side wall 84 for mating engagement with respective corresponding steps 68 and side walls 72 of the body portion 56. The proximal step serves as a valve seat 86. The surface of the valve seat 86 includes a raised annular ring 88, for gripping engagement of a valve 48. One of the steps 82 subtends an angle of less than 90 to form an energy director 90. The neck 78 includes a series of female Luer lock threads, 92 designed for mating engagement with corresponding standard male IV Luer threads in the connector 34. Alternately, a conventional threaded or bayonet-type fitting may be substituted in the neck 78 and connector 34 for the Luer fittings shown and described.
  • As best shown in FIGS. 3-9, the valve member 48 includes a dome portion 94 coupled with an outstanding radial flange or lip portion 96. It is also foreseen that the flange 96 may be of lesser radial extent or omitted entirely. The valve 48 has outer and inner surfaces 98 and 100 respectively and includes a circumferential slit 102 centered on the dome 94. The slit 102 extends across the fluid flow path for providing fluid communication through the valve 48 when it is in an open position. As best shown in FIGS. 3 and 5, the slit 102 is bisected by a central axis C, is coplanar with a slit axis 5, and is crossed by a rib axis R perpendicular to axis S. As shown in FIG. 6, the slit 102 extends lengthwise and has outer and inner margins 104 and 106 and a pair of ends 108 and 110. Because the outer margin 104 is longer than the inner margin 106, the ends 108 and 110 subtend an angle.
  • As illustrated in FIGS. 6 and 7, the outer surface 98 of the valve dome 94 has the symmetrical configuration of a hemisphere. It is also foreseen that the dome 94 may be configured as a spherical cap or chordal segment (the region of a sphere that lies above a chordal plane that does not pass through the center of the sphere) which may be either greater or less than one-half of a sphere. The valve dome 94 need not be strictly hemispherical or partially spherical; however it is preferred that it be at least dome-like or cap-like. The outer and inner surfaces 98 and 100 of the valve dome 94 are not perfectly concentric. The inner surface 100 of the valve dome 94 is depicted as having a generally hemispherical configuration, with a slightly increased curvature as it approaches the axis C. As a result, the dome 94 has a variable wall thickness, which diminishes as it approaches an apex region of the dome 94 at the axis C.
  • The inner surface 100 of the valve dome 94 is shown in FIGS. 4 and 6-7 and in FIG. 5 in phantom to include an elongate rib 112. The rib 112 extends generally circumferentially inwardly in the direction of axis R, perpendicular to and centered on the slit 102, and serves to bias the slit 102 to the closed position depicted in FIG. 3. The rib 112 is of approximately rectangular overall configuration, including a pair of spaced, parallel side surfaces or sides 114 and a pair of ends 116 convergent with the inner surface 100 of the valve dome 94.
  • As shown in FIGS. 6 and 7, the rib 112 has a depth 118 which diminishes as the ends 116 are approached. The rib 112 may be constructed so that the depth 118 also diminishes as the sides 114 are approached. The rib 112 is bisected by the slit 102 at a center portion 120 of the rib. Thus, the wall thickness of the dome thins as it approaches the geometric center of the slit 102, and is reinforced at the center along axis R by the depth of the rib 112. It is foreseen that, rather than bisecting the rib 112, the slit 102 may intersect the rib 112 eccentrically or asymmetrically, or that the slit 102 may be coextensive with the rib 112. It is also foreseen that the ends of the rib 116 could be truncated (not shown) so that the depth 118 does not diminish as the ends 116 are approached, or that the ends 116 could be constructed so that the depth 118 increases as the ends are approached.
  • FIGS. 11 and 12 depict a valve 122 having an alternate rib construction. The structure of the valve 122 is substantially identical to that previously described, and the numbering and description of like elements and axes is hereby adopted and will not be reiterated. The valve 122 includes a circumferential slit 124 centered on the dome 94. The inner surface 100 of the dome 94 includes a rib 126 having an approximately hemi-cylindrical overall configuration, including a curvate surface 128 and a pair of ends 130 convergent with the inner surface 100 of the valve dome 94. As previously described, the rib depth diminishes as the ends 130 are approached.
  • FIGS. 13 and 14 depict a valve 132 having a second alternate rib construction. The structure of the valve 132 is also substantially identical to that previously described, and the numbering and description of like elements and axes is also adopted and will not be reiterated. The valve 132 includes a circumferential slit 134, also centered on the dome 94. The inner surface 100 of the valve dome 94 includes a rib 136 having an approximately X-shaped or cruciform overall configuration. The rib 136 has a first leg 138 and a second leg 140, each of approximately rectangular overall configuration. Each of the legs 138 and 140 include a pair of sides 142 and 144, and a pair of ends 146 and 148 respectively. The first leg 138 is coextensive with the slit 134, whereas the second leg 140 is orthogonal to the slit 134. The leg ends 146 and 148 are convergent with the inner surface 100 of the valve dome 94. As previously described, the rib depth diminishes as the ends 146 and 148 are approached. Those skilled in the art will appreciate that, in addition to the rib configurations previously described, the rib may be of oblong, elliptical, quadrilateral, star-shaped, curvate, compound curvate, circular, curvilinear or any other suitable configuration.
  • The valve dome 94, lip 96 and ribs 112, 126 and 136 are of unitary construction and are formed of a resilient medical grade elastomeric material such as a silicone elastomer. The characteristics of the material used to construct the valve 48 and housing 46, the dimensions of the valve dome 94, flange 96, ribs 112, 126 and 136 and slit 102, 124 or 134 the wall thickness of the valve 48 as well as the magnitude of thinning of the wall as it approaches the top of the dome 94 and location of the slit 102, 124 or 134 (whether centered on the dome or eccentric) are variables which collectively determine both the magnitude and difference between individual pressure differentials P1 and P2 under which the slit 102, 124 or 134 flexes in forward and reverse fluid-enabling manner.
  • The valve assembly 10 may be constructed by aligning the valve member 48 or 122 or 132 on the body portion 56 of the housing 46 that the outer surface 98 of the valve flange 96 engages the body valve seat 72 and projecting stake 74, and is received within cavity 52.
  • The hub 54 is installed over the body 56 with the body and hub steps 68 and 82 in mating engagement and the hub valve seat 86 and projecting ring 88 overlying the valve flange 96. The hub 54 and body 56 are then subject to ultrasonic welding under pressure to form a hermetic seal. The energy director 90 serves to direct the ultrasonic melt, so that the surfaces of the mated steps 68 and 82 fuse and the valve flange 96 is captured between the stake 74 and the ring 88 in a generally S-shaped cross sectional configuration as depicted in FIG. 2. In this manner, the valve 48 or 122 or 132 is secured in place against dislodgement by fluid pressure or force exerted by any object which might be inserted into the housing lumen 50. Alternatively, the hub 54 and body 56 may be secured together by an adhesive composition, by a strictly mechanical junction, or by other arrangements.
  • The valve assembly may be installed in an intravascular device 12 by grasping the housing 47 and using the finger tabs 64 to rotatingly introduce the nipple 58 into the lumen 26 at the proximal end portion 28 of a connector tube 24 until all of the barbs 60 are received within the lumen 26. The barbs 60 serve to frictionally engage the inner surface of the connector tube lumen 26 in a force fit. It is foreseen that, where a single IV line is to be employed, a connector tube 24 may be unnecessary so that the housing 46 may be introduced directly into the catheter lumen 18 at the proximal end of a catheter 16. A connector 34 is aligned over the neck 78 and rotated until the threaded interior surface 36 tightly engages the threads 92 of the neck 78. More than one valve assembly 10 may be installed in-line in an intravascular device 12.
  • In use, the catheter 16 is inserted into a blood vessel of a patient, so that the catheter lumen 18 is in fluidic communication with the patient's blood. If the catheter 16 is to be centrally placed, it is then threaded into a large central vein where it may remain indwelling for a prolonged period of time.
  • An intravascular fluid source or reservoir 14 is coupled with the supply tube 40 that the supply tube lumen 42 is in fluidic communication with the reservoir. Gravity fluid flow is initiated from the fluid source 14 by any conventional means, such as by opening a stopcock or removing a clamp. Fluid flow may also be initiated by actuating a pump. Fluid from the reservoir 14 travels in a flow path through the supply tube 40 into the housing lumen 50 and through the valve 48 or 122 or 132 until it contacts the inner surface 100 of the dome.
  • As shown in FIG. 8, when the forward fluid flow exerts or exceeds a predetermined fluid pressure differential P1 or cracking pressure against the dome inner surface 100, the slit 102 flexes distally to an open, forward flow-enabling position. In valves 122 and 132, similar pressure conditions cause similar flexion of the respective slits 124 and 134. The axial thinning of the dome 94, the shorter length of the slit inner margin 106 with respect to the slit outer margin 104, and the angle subtended by the ends of the slit 108 and 110 all cooperate to facilitate flexing of the slit 102 or 124 or 134 at a relatively low pressure differential, such as is provided by the force of gravity on an elevated fluid reservoir.
  • The slit 102 or 124 or 134 remains in an open position to permit the flow of fluid in a forward direction as long as the pressure differential P1 is maintained against the dome inner surface 100. When the fluid supply in the fluid reservoir 14 is exhausted, the pressure differential against the dome inner surface 100 falls below the cracking pressure P1, and the rib 112, or 122 or 128 serves to bias the slit 102 or 124 or 134 back into a closed, flow-blocking position, depicted in FIG. 7. The rib 112, or 122 or 128 also biases the closed slit margins 104 and 106 into sealing alignment, so that there is no overlap which might permit leakage through the valve. The pressure differential p1 is preselected by design so that the slit 102 or 124 or 134 closes while a fluid head remains in the supply tube 40, so that air does not enter the valve 48 or 122 or 132.
  • At times, it may be necessary to permit reverse fluid flow, for example to withdraw a blood sample. In such instances, a syringe may be inserted into the hub 54 and the plunger withdrawn to create a negative pressure. As shown in FIG. 9, when a predetermined fluid pressure differential P2 or collapsing pressure, is exerted or exceeded against the dome outer surface 98, the slit 102 or 124 or 134 flexes proximally to an open, reverse flow-enabling position. Flexing of the slit is accompanied by proximal collapse of a portion of the dome 94. Because of the axial thinning of the dome 94 in the region of the slit once the pressure differential P2 is reached, only a limited portion of the dome flexes proximally, and the entire dome 94 does not invert into the hub lumen 80. In this manner, the volume of fluid displace back in to the housing lumen 50 is minimized when the pressure falls below P2 and the rib 112 or 122 or 128 biases the slit 102 or 124 or 134 back into a closed, fluid flow blocking position depicted in FIG. 7. Advantageously, the combination of the hemispherical shape of the dome 94, the angular ends of the slit 102, the anterior thinning of the dome 94 in the region of the slit 102 or 124 or 134, and the rib 112 or 122 or 128 combine to provide a valve 48 having a relatively low cracking pressure P1, a relatively high reflux pressure P2 and minimal fluid displacement following reverse fluid flow. This combination of features permits forward fluid flow by gravity from a reservoir and into a patient, while inhibiting thrombus promoting fluid back flow and minimizing reflux volume.
  • The structure of an alternate valve assembly housing is illustrated in FIG. 10 and is generally indicated by the reference numeral 150. The housing 150 has an elongate, generally cylindrical external configuration surrounding a fluid passageway or lumen 152, which widens proximally for receiving the dome-shaped valve member 48 previously described. The housing 150 includes a hub portion 154 and a body portion 156.
  • The distal portion of the body 156 is configured as a standard Luer connector, including a standard Luer taper 158 and standard male Luer lock threaded overmantle 160 or internally threaded collar. The proximal portion of the body 156 and distal portion of the hub 154 are matingly stepped as previously described with respect to the body 56 and hub 54. The proximal portion of the hub 154 is configured with a truncated, Luer threaded top 162.
  • In use, the male Luer body 156 may be rotatingly coupled with any standard female Luer connection, while the female Luer hub 154 may be coupled with any standard male Luer connection in order to install the valve assembly housing 150 in-line between an intravascular fluid source and an indwelling catheter 16. The operation of the valve member 48 within the housing 150 is substantially the same as previously described with respect to the valve member 48 within the housing 46.
  • It is to be understood that while certain forms of the present invention have been illustrated and described herein, it is not to be limited to the specific forms or arrangement of parts described and shown. Having thus described the invention, the following is claimed as new and desired to be secured by Letters Patent:

Claims (11)

1. A pressure actuated flow control valve, comprising:
a. a flexible unitary valve body having a central wall with a convex surface and an opposing concave surface where said central wall defines a fluid passageway portal; and
b. a normally closed slit extending through the wall and between the convex and concave surfaces where the side walls of the slit are in near contact with each other in a normally closed relaxed state and said slit extending partially along the diameter of the central wall.
2. The flow control valve of claim 1, where the central wall is dome-shaped having a substantially spherical geometry.
3. The flow control valve of claim 1, where the central wall has a thickness that diminishes approaching the apical area.
4. The flow control valve of claim 1, where the opposing concave surface has a raised elongated rib extending substantially perpendicular to the slit.
5. The flow control valve of claim 4, where the opposing concave surface has a second raised elongated rib extending substantially along the line of the slit.
6. The flow control valve of claim 1, where the lengthwise opposing first and second ends of the slit are angled such that the arcuate length of the slit is shorter as it penetrates the concave surface than it is when it penetrates the convex surface.
7. The flow control valve of claim 1, where the slit lengthwise end to end is not straight.
8. The flow control valve of claim 1, where the central wall is constructed of material having such material characteristics and said central wall and said slit being so dimensionally configured as to resist opening in response to a selected range of backflow pressure applied to said convex surface to resist a backflow of fluid.
9. The flow control valve of claim 1, where the central wall is constructed of material having such material characteristics and said central wall and said slit being so dimensionally configured such that the normally closed slit opens in response to a predetermined selected range of fluid flow pressure applied to said concave surface to allow a flow of fluid where said slit opens toward said convex surface upon application of a predetermined selected range of fluid flow pressure to said concave surface, enabling forward flow through the portal defined by the central wall and said slit closes to check flow through said portal defined by the central wall at a pressure on said concave surface less than said predetermined selected range of fluid flow pressure.
10. The flow control valve of claim 1, wherein:
a. said slit opens toward said convex surface upon application of a predetermined first fluid pressure to said concave surface, enabling forward flow through said portal defined by the central wall;
b. said slit closes to check flow through said portal defined by the central wall at a pressure on said concave surface less than said first fluid pressure;
c. said slit opens toward said concave surface upon application of a predetermined second fluid pressure to said convex surface, enabling reverse flow through said portal defined by the central wall;
d. said slit closes to check flow through said portal defined by the central wall at a pressure on said convex surface less than said second fluid pressure; and
e. said second fluid pressure is greater than said first fluid pressure.
11. The flow control valve of claim 1, where the flexible unitary body includes an outwardly extending peripheral flange around a base of the unitary body distal from an apical area of the central wall for engaging the flexible unitary body in a fluid flow passageway.
US10/892,762 2002-11-26 2004-07-16 Pressure actuated flow control valve Abandoned US20050010176A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/304,833 US7601141B2 (en) 2002-11-26 2002-11-26 Pressure actuated flow control valve
CA 2452309 CA2452309C (en) 2002-11-26 2003-12-08 Pressure actuated flow control valve
US10/892,762 US20050010176A1 (en) 2002-11-26 2004-07-16 Pressure actuated flow control valve

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/892,762 US20050010176A1 (en) 2002-11-26 2004-07-16 Pressure actuated flow control valve

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/304,833 Continuation-In-Part US7601141B2 (en) 2002-11-26 2002-11-26 Pressure actuated flow control valve

Publications (1)

Publication Number Publication Date
US20050010176A1 true US20050010176A1 (en) 2005-01-13

Family

ID=41201731

Family Applications (7)

Application Number Title Priority Date Filing Date
US10/304,833 Active 2023-07-01 US7601141B2 (en) 2002-11-26 2002-11-26 Pressure actuated flow control valve
US10/892,762 Abandoned US20050010176A1 (en) 2002-11-26 2004-07-16 Pressure actuated flow control valve
US11/953,807 Abandoned US20080086095A1 (en) 2002-11-26 2007-12-10 Pressure actuated flow control valve
US12/492,370 Active US7959614B2 (en) 2002-11-26 2009-06-26 Pressure actuated flow control valve
US12/577,632 Active US8057442B2 (en) 2002-11-26 2009-10-12 Pressure actuated flow control valve
US13/295,807 Active US8328769B2 (en) 2002-11-26 2011-11-14 Pressure actuated flow control valve
US13/618,002 Active US8882742B2 (en) 2002-11-26 2012-09-14 Pressure actuated flow control valve

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/304,833 Active 2023-07-01 US7601141B2 (en) 2002-11-26 2002-11-26 Pressure actuated flow control valve

Family Applications After (5)

Application Number Title Priority Date Filing Date
US11/953,807 Abandoned US20080086095A1 (en) 2002-11-26 2007-12-10 Pressure actuated flow control valve
US12/492,370 Active US7959614B2 (en) 2002-11-26 2009-06-26 Pressure actuated flow control valve
US12/577,632 Active US8057442B2 (en) 2002-11-26 2009-10-12 Pressure actuated flow control valve
US13/295,807 Active US8328769B2 (en) 2002-11-26 2011-11-14 Pressure actuated flow control valve
US13/618,002 Active US8882742B2 (en) 2002-11-26 2012-09-14 Pressure actuated flow control valve

Country Status (2)

Country Link
US (7) US7601141B2 (en)
CA (1) CA2452309C (en)

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050165364A1 (en) * 2004-01-22 2005-07-28 Dimatteo Kristian Valved catheter to bypass connector
US20050171502A1 (en) * 2004-01-29 2005-08-04 Katie Daly Dual well port device
US20050171489A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Pressure activated safety valve with anti-adherent coating
US20050171510A1 (en) * 2004-01-29 2005-08-04 Dicarlo Paul Pressure actuated safety valve with spiral flow membrane
US20050171490A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Stacked membrane for pressure actuated valve
US20060184139A1 (en) * 2005-02-11 2006-08-17 Quigley Karla W Pressure activated safety valve with improved flow characteristics and durability
US20070225648A1 (en) * 2006-03-24 2007-09-27 Chris Winsor Intravenous injection site with split septum and pressure activated flow control valve
US20070276313A1 (en) * 2003-08-29 2007-11-29 Moorehead H R Valved Catheters Including High Flow Rate Catheters
US20090163876A1 (en) * 2007-12-20 2009-06-25 Tyco Healthcare Group Lp Cap Assembly for Use With a Prefilled Lock Solution Syringe
US20090227951A1 (en) * 2005-04-27 2009-09-10 C. R. Bard, Inc Assemblies for identifying a power injectable access port
US20090264832A1 (en) * 2002-11-26 2009-10-22 Nexus Medical, Llc Pressure actuated flow control valve
US20090292252A1 (en) * 2008-05-21 2009-11-26 Raymond Lareau Pressure Activated Valve for High Flow Rate and Pressure Venous Access Applications
US20100063451A1 (en) * 2008-09-09 2010-03-11 Jeff Gray Power Injectable Port Identification
US20100191192A1 (en) * 2009-01-28 2010-07-29 Jayanthi Prasad Three-way Valve for Power Injection in Vascular Access Devices
US20100298782A1 (en) * 2009-05-19 2010-11-25 Nexus Medical, Llc Intravascular valve component with improved valve positioning
US20110087093A1 (en) * 2009-10-09 2011-04-14 Navilyst Medical, Inc. Valve configurations for implantable medical devices
US8034035B2 (en) 2004-01-29 2011-10-11 Navilyst Medical, Inc. Pressure activated safety valve with high flow slit
US8083721B2 (en) 2009-01-29 2011-12-27 Navilyst Medical, Inc. Power injection valve
US8382723B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Access port identification systems and methods
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
US8382724B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
US8529523B2 (en) 2003-06-27 2013-09-10 Navilyst Medical, Inc. Pressure actuated valve with improved biasing member
US8585660B2 (en) 2006-01-25 2013-11-19 Navilyst Medical, Inc. Valved catheter with power injection bypass
US8608713B2 (en) 1998-12-07 2013-12-17 C. R. Bard, Inc. Septum feature for identification of an access port
CN103505772A (en) * 2013-09-30 2014-01-15 苏州市雅思精密模具有限公司 Backflow prevention infusion tube
US8641676B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Infusion apparatuses and methods of use
US8679074B2 (en) 2003-03-18 2014-03-25 Angiodynamics, Inc. Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
US8753320B2 (en) 2009-07-13 2014-06-17 Navilyst Medical, Inc. Method to secure an elastic component in a valve
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US8998860B2 (en) 2005-03-04 2015-04-07 C. R. Bard, Inc. Systems and methods for identifying an access port
US9079004B2 (en) 2009-11-17 2015-07-14 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US9238129B2 (en) 2000-07-11 2016-01-19 Icu Medical, Inc. Medical connector
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9278206B2 (en) 2009-03-25 2016-03-08 Icu Medical, Inc. Medical connectors and methods of use
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US9603993B2 (en) 2005-03-04 2017-03-28 C. R. Bard, Inc. Access port identification systems and methods
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US9750926B2 (en) 2010-05-17 2017-09-05 Icu Medical, Inc. Medical connectors and methods of use
WO2017042825A3 (en) * 2015-09-08 2017-11-16 Neeraj Gupta Intravenous catheter with a secured mechanism to avoid reverse flow of the blood
US9884176B2 (en) 2004-11-05 2018-02-06 Icu Medical, Inc. Medical connector
US9895524B2 (en) 2012-07-13 2018-02-20 Angiodynamics, Inc. Fluid bypass device for valved catheters
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187524A1 (en) * 2000-12-19 2005-08-25 Willis Allan F. Sealing valve assembly for medical products
DE60319115T2 (en) * 2002-08-12 2009-02-05 Jms Co. Ltd. Needle-free opening and manufacturing processes for
US7422571B2 (en) 2002-08-29 2008-09-09 Medical Components, Inc. Releasably locking dilator and sheath assembly
US20040193119A1 (en) * 2003-02-13 2004-09-30 Bernard Canaud Catheter port assembly for extracorporeal treatment
US20040193118A1 (en) * 2003-03-25 2004-09-30 Bergeron Brian J. Valved hub for a catheter
US7951121B2 (en) * 2003-07-30 2011-05-31 Navilyst Medical, Inc. Pressure actuated valve with improved slit configuration
US20050077106A1 (en) * 2004-08-26 2005-04-14 A1A Dock Products, Inc. Swing ladder
US20080275397A1 (en) * 2004-08-31 2008-11-06 Bonnette Michael J Low pierce force needle port
US7491192B2 (en) * 2004-12-30 2009-02-17 C. R. Bard, Inc. Cardiovascular access catheter with slit valve
KR100675913B1 (en) * 2005-02-14 2007-01-29 이상대 Liquid blocking apparatus and liquid blocking monitoring apparatus equipped with an alarm or wireless calling device and a storing bag
US8092432B2 (en) * 2005-05-03 2012-01-10 Nordgren Corporation Outdwelling slit valves and assemblies for medical liquid flow through a cannula and related methods
US20060253084A1 (en) * 2005-05-03 2006-11-09 Greg Nordgren Outdwelling slit valves and assemblies for medical liquid flow through a cannula and related methods
EP1726328A1 (en) * 2005-05-26 2006-11-29 Jean-Pierre Peters Contrast fluid delivery system
CA2608714C (en) * 2005-05-27 2012-09-25 Medical Components, Inc. Catheter port assembly for extracorporeal treatment
US7794422B2 (en) * 2005-05-27 2010-09-14 Medical Components, Inc. Catheter port assembly for extracorporeal treatment
US8359723B2 (en) 2005-06-30 2013-01-29 Abbott Vascular Inc. Introducer sheath and methods of making
US20100130937A1 (en) * 2005-06-30 2010-05-27 Abbott Vascular Inc. Introducer sheath and methods of making
US9168359B2 (en) 2005-06-30 2015-10-27 Abbott Laboratories Modular introducer and exchange sheath
US8440122B2 (en) * 2005-06-30 2013-05-14 Abbott Vascular Inc. Introducer sheath and methods of making
US9352118B2 (en) * 2005-06-30 2016-05-31 Abbott Laboratories Modular introducer and exchange sheath
US20070088253A1 (en) * 2005-10-14 2007-04-19 Yacoubian Vahe S Cannula with extendable distal tip
CN103203054B (en) * 2005-12-02 2016-08-03 C.R.巴德有限公司 Proximal pressure activated valve
US9889275B2 (en) 2006-06-28 2018-02-13 Abbott Laboratories Expandable introducer sheath to preserve guidewire access
US20080004571A1 (en) * 2006-06-28 2008-01-03 Abbott Laboratories Expandable introducer sheath
US9597063B2 (en) * 2006-06-28 2017-03-21 Abbott Laboratories Expandable introducer sheath to preserve guidewire access
US20100198160A1 (en) * 2006-06-28 2010-08-05 Abbott Vascular Inc. Expandable Introducer Sheaths and Methods for Manufacture and Use
US8801744B2 (en) * 2006-06-28 2014-08-12 Abbott Laboratories Expandable introducer sheath to preserve guidewire access
GB2441501A (en) * 2006-09-07 2008-03-12 Gyrus Medical Ltd Surgical instrument with sealing mechanism to retain pressurised gas
US20080086093A1 (en) * 2006-09-18 2008-04-10 Steppe Dennis L Automatic stop cock valve
US8221363B2 (en) 2006-10-18 2012-07-17 Baxter Healthcare S.A. Luer activated device with valve element under tension
US7981090B2 (en) 2006-10-18 2011-07-19 Baxter International Inc. Luer activated device
US7753338B2 (en) 2006-10-23 2010-07-13 Baxter International Inc. Luer activated device with minimal fluid displacement
EP2086623B1 (en) 2006-10-25 2011-04-27 ICU Medical, Inc. Medical connector
JP5613560B2 (en) 2007-06-22 2014-10-22 メディカル コンポーネンツ,インコーポレイテッド Hub for tearaway sheath assembly and the assembly
EP2195063A1 (en) * 2007-09-18 2010-06-16 Medical Components, Inc. Tearaway sheath assembly with split hemostasis valve
US9352129B2 (en) * 2007-12-13 2016-05-31 Medical Components, Inc. Introducer assembly with cap and method of using same
EP2262568A1 (en) 2008-03-14 2010-12-22 Medical Components, Inc. Tearaway introducer sheath with hemostasis valve
US9168366B2 (en) 2008-12-19 2015-10-27 Icu Medical, Inc. Medical connector with closeable luer connector
IT1392987B1 (en) * 2009-02-12 2012-04-02 Cps Color Equipment Spa Dosing valves drip
US9222819B2 (en) 2009-02-20 2015-12-29 University Of Southern California Tracking and controlling fluid delivery from chamber
WO2010096651A2 (en) * 2009-02-20 2010-08-26 University Of Southern California Drug delivery device with in-plane bandpass regulation check valve in heat-shrink packaging
WO2010141118A2 (en) * 2009-02-20 2010-12-09 University Of Southern California Mems electrochemical bellows actuator
USD644731S1 (en) 2010-03-23 2011-09-06 Icu Medical, Inc. Medical connector
KR101122531B1 (en) * 2009-04-13 2012-03-15 (주)이화프레지니우스카비 Device of charging medical liguid and controlling flow thereof and medical liquid injection apparatus comprising the same
US20110118612A1 (en) * 2009-11-18 2011-05-19 Navilyst Medical, Inc. Valved Catheter with Integrated Pressure Measurement Capabilities
US8814833B2 (en) 2010-05-19 2014-08-26 Tangent Medical Technologies Llc Safety needle system operable with a medical device
US20120157913A1 (en) * 2010-12-16 2012-06-21 Atherolysis Medical, Inc. Catheter apparatus and method for atherolysis
USD667106S1 (en) * 2011-01-25 2012-09-11 Nordic Med-Com Ab Catheter
CN103648543A (en) * 2011-05-06 2014-03-19 赛诺菲-安万特德国有限公司 Flexible valve geometry for the use of rigid materials
EP3381505A1 (en) 2011-09-09 2018-10-03 ICU Medical, Inc. Medical connectors with fluid-resistant mating interfaces
US9332998B2 (en) 2012-08-13 2016-05-10 Covidien Lp Apparatus and methods for clot disruption and evacuation
US9332999B2 (en) 2012-08-13 2016-05-10 Covidien Lp Apparatus and methods for clot disruption and evacuation
AU2013342123B2 (en) 2012-11-12 2018-08-02 Icu Medical, Inc. Medical connector
IL224061A (en) * 2012-12-31 2018-05-31 Vaserman Elchanan One way valve for pressurized containers
US8814849B1 (en) 2013-02-14 2014-08-26 Nexus Medical, Llc Infusion check valve for medical devices
CN105163796B (en) 2013-03-15 2018-06-01 Icu医学有限公司 Medical connector
EP2968898B1 (en) * 2013-03-16 2018-08-22 Poly Medicure Limited Transfer device valve
JP6063036B2 (en) * 2013-04-01 2017-01-18 テルモ株式会社 Connector and infusion set
CN104922748A (en) * 2014-01-08 2015-09-23 B.布劳恩梅尔松根股份公司 Catheter Assemblies With Valves And Related Methods
CA2937744A1 (en) 2014-02-04 2015-08-13 Icu Medical, Inc. Self-priming systems and methods
EP3142726A1 (en) * 2014-05-14 2017-03-22 AptarGroup, Inc. Integrated valve assembly
CA2949402A1 (en) * 2014-07-01 2016-01-07 Edwards Lifesciences Corporation Self-sealing infusion catheter
USD793551S1 (en) 2014-12-03 2017-08-01 Icu Medical, Inc. Fluid manifold
USD786427S1 (en) 2014-12-03 2017-05-09 Icu Medical, Inc. Fluid manifold
CN104399145B (en) * 2014-12-18 2016-11-23 邓杜娟 One kind of double lumen tubing puncture intravenous catheter
USD794781S1 (en) * 2015-04-13 2017-08-15 Medela Holding Ag Valve component for a breastmilk collection system
US20180311489A1 (en) * 2015-10-30 2018-11-01 Aptargroup, Inc. Flow control valve
WO2018025094A1 (en) 2016-08-01 2018-02-08 Poly Medicure Limited Intravenous catheter apparatus with safety function and pressure controlled valve element
USD831201S1 (en) 2016-08-29 2018-10-16 Medela Holding Ag Safety valve component for a breastmilk collection system
USD808013S1 (en) 2016-10-27 2018-01-16 Smiths Medical Asd, Inc. Catheter

Citations (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US274447A (en) * 1883-03-20 William-kentish
US1923501A (en) * 1933-01-12 1933-08-22 Agnes S Perry Air valve and the like
US4143853A (en) * 1977-07-14 1979-03-13 Metatech Corporation Valve for use with a catheter or the like
US4434810A (en) * 1980-07-14 1984-03-06 Vernay Laboratories, Inc. Bi-directional pressure relief valve
US4995863A (en) * 1986-10-06 1991-02-26 Catheter Technology Corporation Catheter with slit valve
US5147313A (en) * 1990-10-22 1992-09-15 Entracare Corporation Medical fluid delivery system with uniquely configured pump unit and fluid delivery set
US5147332A (en) * 1991-05-17 1992-09-15 C.R. Bard, Inc. Multi-valve catheter for improved reliability
US5160325A (en) * 1986-10-06 1992-11-03 C. R. Bard, Inc. Catheter with novel lumens shapes
US5169393A (en) * 1990-09-04 1992-12-08 Robert Moorehead Two-way outdwelling slit valving of medical liquid flow through a cannula and methods
US5201722A (en) * 1990-09-04 1993-04-13 Moorehead Robert H Two-way outdwelling slit valving of medical liquid flow through a cannula and methods
US5205834A (en) * 1990-09-04 1993-04-27 Moorehead H Robert Two-way outdwelling slit valving of medical liquid flow through a cannula and methods
US5249598A (en) * 1992-08-03 1993-10-05 Vernay Laboratories, Inc. Bi-directional vent and overpressure relief valve
US5251873A (en) * 1992-06-04 1993-10-12 Vernay Laboratories, Inc. Medical coupling site
US5295658A (en) * 1987-04-27 1994-03-22 Vernay Laboratories, Inc. Medical coupling site including slit reinforcing members
US5389091A (en) * 1991-03-07 1995-02-14 C. R. Bard, Inc. Site-selective durability-enhanced catheter and methods of manufacturing and using same
US5409471A (en) * 1993-07-06 1995-04-25 Vernay Laboratories, Inc. Method of lubricating a medical coupling site
US5431202A (en) * 1993-09-17 1995-07-11 W. Cary Dikeman Medical fluid flow control system and compounder apparatus
US5501426A (en) * 1992-06-04 1996-03-26 Vernay Laboratories, Inc. Medical coupling site valve body
US5533708A (en) * 1992-06-04 1996-07-09 Vernay Laboratories, Inc. Medical coupling site valve body
US5843044A (en) * 1997-06-16 1998-12-01 Catheter Innovations Outdwelling slit valve and variable control for controlling opening and closing the slit
US6024729A (en) * 1998-03-10 2000-02-15 Vernay Laboratories, Inc. Hemostasis valve assembly including guide wire seal
US6270489B1 (en) * 1999-07-01 2001-08-07 Catheter Innovations, Inc. Anti-clotting methods and apparatus for indwelling catheter tubes
US6364687B1 (en) * 2000-07-18 2002-04-02 L&K Precision Industry Co., Ltd. Cable connector

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US649628A (en) * 1898-01-31 1900-05-15 William Arthur Caldecott Extraction of gold or other precious metals from slimes.
US2524764A (en) 1944-04-12 1950-10-10 Adrian P Burke Valve construction
US2524754A (en) * 1945-06-19 1950-10-10 Lumalampan Ab Unitary magnetic core and condenser
US3517682A (en) * 1967-09-28 1970-06-30 Flo Container Inc Inflation means
US4181145A (en) 1978-05-10 1980-01-01 General Motors Corporation Two-way check valve
US4341239A (en) 1980-07-14 1982-07-27 Vernay Laboratories, Inc. Combination check-overpressure relief valve
US4895565A (en) 1987-09-21 1990-01-23 Cordis Corporation Medical instrument valve
US5149327A (en) 1989-09-05 1992-09-22 Terumo Kabushiki Kaisha Medical valve, catheter with valve, and catheter assembly
US5360413A (en) 1991-12-06 1994-11-01 Filtertek, Inc. Needleless access device
US5356396A (en) 1992-09-29 1994-10-18 Medical Associates Network Inc. Infusion apparatus
US5603706A (en) 1992-09-29 1997-02-18 Wyatt; Philip Infusion apparatus
FR2707505B1 (en) 1993-07-13 1995-09-01 Celsa Lg Catheter valve double axial direction.
JP3846918B2 (en) * 1994-08-02 2006-11-15 富士通株式会社 An optical transmission system, an optical multiplex transmission system and its peripheral technologies
JPH118590A (en) * 1997-04-25 1999-01-12 Oki Electric Ind Co Ltd Optical transmission system and supervisory and control method therefor
DE69841253D1 (en) 1997-07-30 2009-12-03 Cook Inc Medical flow control valve
US5928203A (en) 1997-10-01 1999-07-27 Boston Scientific Corporation Medical fluid infusion and aspiration
US6496288B2 (en) * 1997-10-17 2002-12-17 Fujitsu Limited Wavelength multiplexing transmission apparatus and wavelength demultiplexing reception apparatus
JP3603082B2 (en) * 1997-10-17 2004-12-15 富士通株式会社 WDM device
US5989224A (en) 1998-02-23 1999-11-23 Dexide Corporation Universal seal for use with endoscopic cannula
US6133833A (en) * 1999-02-25 2000-10-17 Motorola, Inc. Wireless add-on keyboard system and method
US6373469B1 (en) * 1999-08-10 2002-04-16 Dexin Corporation Radio frequency computer mouse
US6650254B1 (en) * 2000-03-13 2003-11-18 Ergodex Computer input device with individually positionable and programmable switches
US7006014B1 (en) * 2000-10-17 2006-02-28 Henty David L Computer system with passive wireless keyboard
US7525453B2 (en) * 2000-10-17 2009-04-28 Henty David L Computer system with enhanced range passive wireless keyboard
US7601141B2 (en) 2002-11-26 2009-10-13 Nexus Medical, Llc Pressure actuated flow control valve
US8211089B2 (en) 2006-03-24 2012-07-03 Nexus Medical, Llc Intravenous injection site with split septum and pressure activated flow control valve

Patent Citations (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US274447A (en) * 1883-03-20 William-kentish
US1923501A (en) * 1933-01-12 1933-08-22 Agnes S Perry Air valve and the like
US4143853A (en) * 1977-07-14 1979-03-13 Metatech Corporation Valve for use with a catheter or the like
US4434810A (en) * 1980-07-14 1984-03-06 Vernay Laboratories, Inc. Bi-directional pressure relief valve
US4995863A (en) * 1986-10-06 1991-02-26 Catheter Technology Corporation Catheter with slit valve
US5160325A (en) * 1986-10-06 1992-11-03 C. R. Bard, Inc. Catheter with novel lumens shapes
US5295658A (en) * 1987-04-27 1994-03-22 Vernay Laboratories, Inc. Medical coupling site including slit reinforcing members
US5169393A (en) * 1990-09-04 1992-12-08 Robert Moorehead Two-way outdwelling slit valving of medical liquid flow through a cannula and methods
US5201722A (en) * 1990-09-04 1993-04-13 Moorehead Robert H Two-way outdwelling slit valving of medical liquid flow through a cannula and methods
US5205834A (en) * 1990-09-04 1993-04-27 Moorehead H Robert Two-way outdwelling slit valving of medical liquid flow through a cannula and methods
US5147313A (en) * 1990-10-22 1992-09-15 Entracare Corporation Medical fluid delivery system with uniquely configured pump unit and fluid delivery set
US5389091A (en) * 1991-03-07 1995-02-14 C. R. Bard, Inc. Site-selective durability-enhanced catheter and methods of manufacturing and using same
US5147332A (en) * 1991-05-17 1992-09-15 C.R. Bard, Inc. Multi-valve catheter for improved reliability
US5251873B1 (en) * 1992-06-04 1995-05-02 Vernay Laboratories Medical coupling site.
US5251873A (en) * 1992-06-04 1993-10-12 Vernay Laboratories, Inc. Medical coupling site
US5533708A (en) * 1992-06-04 1996-07-09 Vernay Laboratories, Inc. Medical coupling site valve body
US5402982A (en) * 1992-06-04 1995-04-04 Vernay Laboratories, Inc. Medical coupling site valve body
US5501426A (en) * 1992-06-04 1996-03-26 Vernay Laboratories, Inc. Medical coupling site valve body
US5295657A (en) * 1992-06-04 1994-03-22 Vernay Laboratories, Inc. Medical coupling site valve body
US5249598A (en) * 1992-08-03 1993-10-05 Vernay Laboratories, Inc. Bi-directional vent and overpressure relief valve
US5409471A (en) * 1993-07-06 1995-04-25 Vernay Laboratories, Inc. Method of lubricating a medical coupling site
US5431202A (en) * 1993-09-17 1995-07-11 W. Cary Dikeman Medical fluid flow control system and compounder apparatus
US5843044A (en) * 1997-06-16 1998-12-01 Catheter Innovations Outdwelling slit valve and variable control for controlling opening and closing the slit
US6024729A (en) * 1998-03-10 2000-02-15 Vernay Laboratories, Inc. Hemostasis valve assembly including guide wire seal
US6270489B1 (en) * 1999-07-01 2001-08-07 Catheter Innovations, Inc. Anti-clotting methods and apparatus for indwelling catheter tubes
US6364687B1 (en) * 2000-07-18 2002-04-02 L&K Precision Industry Co., Ltd. Cable connector

Cited By (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8608713B2 (en) 1998-12-07 2013-12-17 C. R. Bard, Inc. Septum feature for identification of an access port
US9238129B2 (en) 2000-07-11 2016-01-19 Icu Medical, Inc. Medical connector
US20090264832A1 (en) * 2002-11-26 2009-10-22 Nexus Medical, Llc Pressure actuated flow control valve
US7959614B2 (en) 2002-11-26 2011-06-14 Nexus Medical, Llc Pressure actuated flow control valve
US8057442B2 (en) 2002-11-26 2011-11-15 Nexus Medical, Llc Pressure actuated flow control valve
US8679074B2 (en) 2003-03-18 2014-03-25 Angiodynamics, Inc. Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
US8529523B2 (en) 2003-06-27 2013-09-10 Navilyst Medical, Inc. Pressure actuated valve with improved biasing member
US20070276313A1 (en) * 2003-08-29 2007-11-29 Moorehead H R Valved Catheters Including High Flow Rate Catheters
US8079987B2 (en) 2003-08-29 2011-12-20 Navilyst Medical, Inc. Valved catheters including high flow rate catheters
US8540685B2 (en) 2003-08-29 2013-09-24 Navilyst Medical, Inc. Valved catheters including high flow rate catheters
US20050165364A1 (en) * 2004-01-22 2005-07-28 Dimatteo Kristian Valved catheter to bypass connector
US8187234B2 (en) * 2004-01-29 2012-05-29 Navilyst Medical, Inc. Pressure activated safety valve with anti-adherent coating
US8267915B2 (en) 2004-01-29 2012-09-18 Navilyst Medical, Inc. Dual well port device
US20050171510A1 (en) * 2004-01-29 2005-08-04 Dicarlo Paul Pressure actuated safety valve with spiral flow membrane
US8377011B2 (en) 2004-01-29 2013-02-19 Angiodynamics, Inc. Pressure activated valve with high flow slit
US20050171502A1 (en) * 2004-01-29 2005-08-04 Katie Daly Dual well port device
US8454574B2 (en) 2004-01-29 2013-06-04 Navilyst Medical, Inc. Pressure activated safety valve with grooved membrane
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US20050171490A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Stacked membrane for pressure actuated valve
US8034035B2 (en) 2004-01-29 2011-10-11 Navilyst Medical, Inc. Pressure activated safety valve with high flow slit
US20050171489A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Pressure activated safety valve with anti-adherent coating
US9884176B2 (en) 2004-11-05 2018-02-06 Icu Medical, Inc. Medical connector
US8328768B2 (en) 2005-02-11 2012-12-11 Angiodynamics, Inc Pressure activated safety valve with improved flow characteristics and durability
US20060184139A1 (en) * 2005-02-11 2006-08-17 Quigley Karla W Pressure activated safety valve with improved flow characteristics and durability
US8603052B2 (en) 2005-03-04 2013-12-10 C. R. Bard, Inc. Access port identification systems and methods
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US9603992B2 (en) 2005-03-04 2017-03-28 C. R. Bard, Inc. Access port identification systems and methods
US9682186B2 (en) 2005-03-04 2017-06-20 C. R. Bard, Inc. Access port identification systems and methods
US9603993B2 (en) 2005-03-04 2017-03-28 C. R. Bard, Inc. Access port identification systems and methods
US10265512B2 (en) 2005-03-04 2019-04-23 Bard Peripheral Vascular, Inc. Implantable access port including a sandwiched radiopaque insert
US10179230B2 (en) 2005-03-04 2019-01-15 Bard Peripheral Vascular, Inc. Systems and methods for radiographically identifying an access port
US8998860B2 (en) 2005-03-04 2015-04-07 C. R. Bard, Inc. Systems and methods for identifying an access port
US8585663B2 (en) 2005-03-04 2013-11-19 C. R. Bard, Inc. Access port identification systems and methods
US8382723B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Access port identification systems and methods
US8939947B2 (en) 2005-03-04 2015-01-27 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US8382724B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US10238850B2 (en) 2005-03-04 2019-03-26 Bard Peripheral Vascular, Inc. Systems and methods for radiographically identifying an access port
US9937337B2 (en) 2005-04-27 2018-04-10 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US8475417B2 (en) 2005-04-27 2013-07-02 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US8641688B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US8641676B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Infusion apparatuses and methods of use
US10016585B2 (en) 2005-04-27 2018-07-10 Bard Peripheral Vascular, Inc. Assemblies for identifying a power injectable access port
US10052470B2 (en) 2005-04-27 2018-08-21 Bard Peripheral Vascular, Inc. Assemblies for identifying a power injectable access port
US8545460B2 (en) 2005-04-27 2013-10-01 C. R. Bard, Inc. Infusion apparatuses and related methods
US10183157B2 (en) 2005-04-27 2019-01-22 Bard Peripheral Vascular, Inc. Assemblies for identifying a power injectable access port
US20090227951A1 (en) * 2005-04-27 2009-09-10 C. R. Bard, Inc Assemblies for identifying a power injectable access port
US9421352B2 (en) 2005-04-27 2016-08-23 C. R. Bard, Inc. Infusion apparatuses and methods of use
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device
US8585660B2 (en) 2006-01-25 2013-11-19 Navilyst Medical, Inc. Valved catheter with power injection bypass
US20070225648A1 (en) * 2006-03-24 2007-09-27 Chris Winsor Intravenous injection site with split septum and pressure activated flow control valve
WO2007112278A2 (en) 2006-03-24 2007-10-04 Nexus Medical, Llc. Intravenous injection site split septum and pressure activated flow control valve
WO2007112278A3 (en) * 2006-03-24 2008-03-06 Nexus Medical Llc Intravenous injection site split septum and pressure activated flow control valve
US8211089B2 (en) 2006-03-24 2012-07-03 Nexus Medical, Llc Intravenous injection site with split septum and pressure activated flow control valve
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US10092725B2 (en) 2006-11-08 2018-10-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US10086186B2 (en) 2007-11-07 2018-10-02 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US8100885B2 (en) 2007-12-20 2012-01-24 Tyco Healthcare Group Lp Cap assembly for use with a prefilled lock solution syringe
US20090163876A1 (en) * 2007-12-20 2009-06-25 Tyco Healthcare Group Lp Cap Assembly for Use With a Prefilled Lock Solution Syringe
US8496643B2 (en) 2007-12-20 2013-07-30 Covidien Lp Cap assembly for use with a prefilled lock solution syringe
US8257321B2 (en) 2008-05-21 2012-09-04 Navilyst Medical, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US20090292252A1 (en) * 2008-05-21 2009-11-26 Raymond Lareau Pressure Activated Valve for High Flow Rate and Pressure Venous Access Applications
US9447892B2 (en) 2008-05-21 2016-09-20 Angiodynamics, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US20100063451A1 (en) * 2008-09-09 2010-03-11 Jeff Gray Power Injectable Port Identification
US8075536B2 (en) 2008-09-09 2011-12-13 Navilyst Medical, Inc. Power injectable port identification
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US10052471B2 (en) 2008-11-13 2018-08-21 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US20100191192A1 (en) * 2009-01-28 2010-07-29 Jayanthi Prasad Three-way Valve for Power Injection in Vascular Access Devices
US8337470B2 (en) 2009-01-28 2012-12-25 Angiodynamics, Inc. Three-way valve for power injection in vascular access devices
US8523821B2 (en) 2009-01-29 2013-09-03 Navilyst Medical, Inc Power injection valve
US8083721B2 (en) 2009-01-29 2011-12-27 Navilyst Medical, Inc. Power injection valve
US9278206B2 (en) 2009-03-25 2016-03-08 Icu Medical, Inc. Medical connectors and methods of use
US10086188B2 (en) 2009-03-25 2018-10-02 Icu Medical, Inc. Medical connectors and methods of use
US9440060B2 (en) 2009-03-25 2016-09-13 Icu Medical, Inc. Medical connectors and methods of use
US20100298782A1 (en) * 2009-05-19 2010-11-25 Nexus Medical, Llc Intravascular valve component with improved valve positioning
US7967797B2 (en) 2009-05-19 2011-06-28 Nexus Medical, Llc Intravascular valve component with improved valve positioning
US8753320B2 (en) 2009-07-13 2014-06-17 Navilyst Medical, Inc. Method to secure an elastic component in a valve
US20110087093A1 (en) * 2009-10-09 2011-04-14 Navilyst Medical, Inc. Valve configurations for implantable medical devices
US9717895B2 (en) 2009-11-17 2017-08-01 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US9079004B2 (en) 2009-11-17 2015-07-14 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US10155101B2 (en) 2009-11-17 2018-12-18 Bard Peripheral Vascular, Inc. Overmolded access port including anchoring and identification features
US9248268B2 (en) 2009-11-17 2016-02-02 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US10195413B2 (en) 2010-05-17 2019-02-05 Icu Medical, Inc. Medical connectors and methods of use
US9750926B2 (en) 2010-05-17 2017-09-05 Icu Medical, Inc. Medical connectors and methods of use
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
US9895524B2 (en) 2012-07-13 2018-02-20 Angiodynamics, Inc. Fluid bypass device for valved catheters
CN103505772A (en) * 2013-09-30 2014-01-15 苏州市雅思精密模具有限公司 Backflow prevention infusion tube
WO2017042825A3 (en) * 2015-09-08 2017-11-16 Neeraj Gupta Intravenous catheter with a secured mechanism to avoid reverse flow of the blood

Also Published As

Publication number Publication date
US20040102738A1 (en) 2004-05-27
US8328769B2 (en) 2012-12-11
US20130012870A1 (en) 2013-01-10
US7601141B2 (en) 2009-10-13
US8057442B2 (en) 2011-11-15
US20080086095A1 (en) 2008-04-10
CA2452309A1 (en) 2005-06-08
US20120059312A1 (en) 2012-03-08
CA2452309C (en) 2011-11-22
US7959614B2 (en) 2011-06-14
US20100036328A1 (en) 2010-02-11
US8882742B2 (en) 2014-11-11
US20090264832A1 (en) 2009-10-22

Similar Documents

Publication Publication Date Title
US8679074B2 (en) Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
AU703589B2 (en) Valved intravenous fluid line infusion device
US8574203B2 (en) Systems and methods for providing a flushable catheter assembly
ES2671333T3 (en) Rinse syringe positive displacement
US5273546A (en) Hemostasis valve
CA2267581C (en) Self-priming needle-free "y"-adapter
US4950254A (en) Valve means for enteral therapy administration set
EP0513991B1 (en) Multi-valve catheter for improved reliability
US6632200B2 (en) Hemostasis valve
US8048038B2 (en) Valve connector for medical lines
US5064416A (en) Self-occluding intravascular cannula assembly
US5125903A (en) Hemostasis valve
EP0900105B1 (en) Hemostasis valve
US7329249B2 (en) Needleless Luer activated medical connector
US20140107588A1 (en) Medical connectors and methods of use
US20030050604A1 (en) Splittable medical valve
US8858533B2 (en) Methods and systems for providing fluid communication with a gastrostomy tube
AU2004240551B2 (en) Self-sealing male connector
US6050978A (en) Needleless valve connector
US7413564B2 (en) Slit valve catheters
US7530546B2 (en) Swabbable needle-free injection port valve system with zero fluid displacement
US5782816A (en) Bi-directional valve and method of using same
US20040068248A1 (en) Vascular access devices having hemostatic safety valve
AU2004257698B2 (en) Detachable hemostasis valve and splittable sheath assembly
CA2552084C (en) Swabbable needle-free injection port valve system with neutral fluid displacement

Legal Events

Date Code Title Description
STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION