US20040076525A1 - Microfluidic device for the manipulation of a non-magnetic liquid - Google Patents

Microfluidic device for the manipulation of a non-magnetic liquid Download PDF

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Publication number
US20040076525A1
US20040076525A1 US10/450,553 US45055303A US2004076525A1 US 20040076525 A1 US20040076525 A1 US 20040076525A1 US 45055303 A US45055303 A US 45055303A US 2004076525 A1 US2004076525 A1 US 2004076525A1
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US
United States
Prior art keywords
magnetic
magnetic liquid
liquid
cell
manipulation
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Abandoned
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US10/450,553
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English (en)
Inventor
Constantin Olivier
Patrick Pouteau
Yves Fouillet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
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Commissariat a lEnergie Atomique CEA
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Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Assigned to COMMISSARIAT A L'ENERGIE ATOMIQUE reassignment COMMISSARIAT A L'ENERGIE ATOMIQUE ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CONSTANTIN, OLIVIER, FOUILLET, YVES, POUTEAU, PATRICK
Publication of US20040076525A1 publication Critical patent/US20040076525A1/en
Abandoned legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K31/00—Actuating devices; Operating means; Releasing devices
    • F16K31/02—Actuating devices; Operating means; Releasing devices electric; magnetic
    • F16K31/06—Actuating devices; Operating means; Releasing devices electric; magnetic using a magnet, e.g. diaphragm valves, cutting off by means of a liquid
    • F16K31/08—Actuating devices; Operating means; Releasing devices electric; magnetic using a magnet, e.g. diaphragm valves, cutting off by means of a liquid using a permanent magnet
    • F16K31/086—Actuating devices; Operating means; Releasing devices electric; magnetic using a magnet, e.g. diaphragm valves, cutting off by means of a liquid using a permanent magnet the magnet being movable and actuating a second magnet connected to the closing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K13/00—Other constructional types of cut-off apparatus; Arrangements for cutting-off
    • F16K13/08—Arrangements for cutting-off not used
    • F16K13/10—Arrangements for cutting-off not used by means of liquid or granular medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Definitions

  • the invention relates to a microfluidic device for the manipulation of a non-magnetic liquid.
  • a microfluidic device for the manipulation of a non-magnetic liquid.
  • Such a device can be used in the field of biochips, in the pharmaceutical industry, and in fine chemistry. It can also be used for the manipulation of dangerous liquids.
  • Active microfluidic devices are already known (valves, pumps, etc.), manufactured by MEMS (Micro-Electro-Mechanical Systems) technologies employing techniques of micro-machining and of assembly of substrates and thin layers.
  • MEMS Micro-Electro-Mechanical Systems
  • the article “Micro-systems in biomedical applications” by P. DARIO et al., J. Micromech. Microeng. 10 (2000), pages 235-244, may be referred to on this subject.
  • These active microfluidic devices comprise movable mechanical elements which are difficult to produce and have a limited lifetime.
  • a reconfigurable active microfluidic device using a magnetic liquid to form a wall for a volume of a non-magnetic liquid to be manipulated.
  • This wall is formed by creating a deformation in the volume of magnetic liquid.
  • This deformation enables a non-magnetic liquid, immiscible with the magnetic liquid (or plural non-magnetic liquids, immiscible with the magnetic liquid) to be integrated into the device.
  • This or these non-magnetic liquid(s) may be termed “contained liquid(s)”. It is possible by control of the magnetic means to cause the displacement or the transformation (division, mixing, etc.) of the volume of contained liquid.
  • the invention thus has as its object a microfluidic device for the manipulation of a non-magnetic liquid, comprising at least one cell comprising:
  • magnetic means associated with the enclosure and permitting the local application to the magnetic liquid of a magnetic field, the energy profile of which has a depression giving rise to at least one volume for reception of the non-magnetic liquid, by forcing the magnetic liquid back, said magnetic field being capable of being displaced to permit a manipulation of the non-magnetic liquid between said introduction means and said evacuation means.
  • the means for introduction of the non-magnetic liquid may comprise at least one inlet orifice.
  • the means for evacuation of the non-magnetic liquid may comprise at least one outlet orifice.
  • the magnetic means may comprise at least one permanent magnet and/or at least one fixed or movable electromagnetic element.
  • the cell comprises a flat enclosure, constituted from two parallel plates confining the magnetic liquid in the form of a sheet.
  • the magnetic means can be supported by at least one of the two plates and/or integrated with at least one of the two plates. At least one of the plates has its face internal to the cell treated to facilitate the manipulation of the non-magnetic liquid and/or of the magnetic liquid.
  • the magnetic means may comprise a writeable magnetic material. This writeable magnetic material (magnetic tape or disk) may be transformed into a permanent magnet of chosen form by a writing operation of the same type as that used for data storage. This operation may be performed before the assembly of the confinement enclosure or afterward, just before the manipulation.
  • the magnetic means may also comprise at least one matrix of individually addressable and/or switchable electromagnetic elements. They may be fixed or movable.
  • the magnetic means comprise at least one tubular permanent magnet with its axis perpendicular to the sheet of magnetic liquid and with its magnetization perpendicular to the sheet of magnetic liquid.
  • the volume for receiving the non-magnetic liquid then corresponds to the depression of magnetic energy existing in the axis of the tubular permanent magnet.
  • the magnetic means comprise two mutually parallel magnetized bars, with magnetization perpendicular to the sheet of magnetic liquid.
  • the volume for receiving the non-magnetic liquid then corresponds to the depression of magnetic energy existing between the two bars.
  • This device can furthermore comprise means for conjointly displacing the two magnetized bars between at least a first position and a second position.
  • the means for conjointly displacing the two magnetized bars may cause a displacement by rotation and/or by translation of the two magnetized bars.
  • the two magnetized bars may possess means causing at least one localized restriction of the volume for receiving the non-magnetic liquid, the means for conjointly displacing the two magnetized bars causing, by the displacement of these bars, the propulsion of the non-magnetic liquid contained in the receiving volume.
  • the device may comprise at least two adjacent cells, with the non-magnetic liquid evacuation means of the cell communicating with the non-magnetic liquid introduction means of the adjacent cell.
  • Two adjacent cells may have a common plate and thus be superposed.
  • FIG. 1 is a diagram showing an energy profile of a magnetic field used by the present invention
  • FIG. 2 is a partial perspective view of a first microfluidic device for the manipulation of a non-magnetic liquid, according to the invention
  • FIG. 3 is a partial perspective view of a second microfluidic device for the manipulation of a non-magnetic liquid, according to the invention.
  • FIG. 4 is a view explaining the functioning of a microfluidic device permitting the projection of a non-magnetic liquid, according to the invention
  • FIG. 5 is a view from above of another microfluidic device for the manipulation of a non-magnetic liquid, according to the invention.
  • FIG. 6 is a perspective view of the principal parts of yet another microfluidic device for the manipulation of a non-magnetic liquid, according to the invention.
  • FIG. 1 is a diagram showing an energy profile E CM of a magnetic field as a function of a direction x.
  • E CM energy profile of a magnetic field as a function of a direction x.
  • the magnetic liquid tends to leave the zone where the energy of the magnetic field is weak, for its periphery, where the energy of the magnetic field is strong, leaving space free for another liquid which is non-magnetic and immiscible with the magnetic liquid. This non-magnetic liquid is then confined by walls of magnetic liquid.
  • the magnetic liquids which may be used by the invention are constituted by solid magnetic particles in suspension in a liquid matrix which is aqueous (ionic magnetic liquids) or oily (oily magnetic liquids).
  • the non-magnetic liquids which may be manipulated, or contained liquids are solutions which may or may not contain suspended particles. These particles may be solid (non-magnetic materials), biological (inert or living) or a combination of the two.
  • the device according to the invention is reconfigurable because the walls of the containing magnetic liquid can be modified at will, according to a predetermined choice.
  • the volume of magnetic liquid can be delimited by two solid, mutually parallel plates, forming a cell for manipulation of non-magnetic fluids.
  • FIG. 2 is a partial perspective view of such a cell. It shows two flat plates 1 and 2 , mutually parallel and spaced apart by a sub-millimeter distance.
  • the cell comprises, for example, an inlet capillary 3 ending perpendicularly on the plate 1 and an outlet capillary 4 parallel to the plane of the cell.
  • the cell is filled with a magnetic liquid 5 , immiscible with the fluid to be manipulated.
  • the magnetic liquid 5 forms a sheet.
  • the cell is closed at its periphery by elements which are not shown.
  • the cell is designed to receive a certain quantity of magnetic fluid and to be capable of creating there a receiving volume for non-magnetic fluid.
  • the plates 1 and 2 may be of a material chosen to permit an increase of the internal volume of the cell.
  • the magnetic field profile may be obtained by a tubular permanent magnet 6 placed, for example, under the plate 2 .
  • a magnetic field energy hole is created in the axis of the tubular magnet, enabling a drop 7 of non-magnetic liquid to be confined by the walls formed by the magnetic liquid 5 .
  • the magnetic field energy profile is likewise displaced, as well as the wall of magnetic liquid.
  • the drop 7 can thus be brought, by a desired path, from the inlet capillary 3 to the outlet capillary 4 .
  • the displacement of the walls of magnetic liquid can take place in two dimensions and in any direction chosen by the manipulator.
  • the magnet 6 can be embodied by a steel tube of 3 mm internal diameter and 10 mm external diameter, placed on a cylindrical magnet of NdFeB, 10 mm in diameter.
  • the magnetic field used is 0.12 T, for example.
  • This magnetic field permits a drop of non-magnetic, immiscible liquid 3 mm in diameter (that is, less than 4 ⁇ l) to be displaced in a sheet of magnetic liquid in any direction in the plane of the sheet.
  • the drop of contained liquid is formed under the inlet capillary 3 by pressure, this capillary being connected to a syringe of non-magnetic liquid installed in a syringe pusher. Once the drop is formed, its displacement is controlled magnetically.
  • FIG. 3 is a partial sectional view of another device according to the present invention.
  • the cell of the device comprises, as for the foregoing device, two plates 11 and 12 for confinement of a magnetic liquid 15 , immiscible with the non-magnetic liquid to be manipulated.
  • Two mutually parallel magnetized bars 13 and 14 are disposed under the plate 12 . Their magnetization is perpendicular to the plane of the cell. A channel free from magnetic liquid is then formed in the sheet of magnetic liquid above the space comprised between the two bars 13 and 14 . This channel is formed when a non-magnetic liquid is caused to circulate. By conjointly displacing the bars 13 and 14 under the plate 12 , the walls of magnetic liquid are displaced. A microfluidic pointer is obtained by swinging the channel, for example, from an inlet capillary 16 /outlet capillary 17 axis to an inlet capillary 16 /outlet capillary 18 axis.
  • a restriction of a channel delimited by the walls of a magnetic liquid can be obtained by means of two bars 23 and 24 (see FIG. 4, which shows a restriction seen from above).
  • the bars 23 and 24 have two perpendicular extensions, respectively 27 and 28 , which cause a restriction of the channel containing the non-magnetic liquid 25 .
  • By displacing the bars 23 and 24 there can be obtained a propulsion of the non-magnetic fluid comprised in the neighborhood of the space defined by these bars.
  • the plates delimiting the cell may be chosen such that their walls internal to the cell are chemically or biochemically compatible with the liquids to be manipulated. The same holds for the magnetic liquid.
  • the plates may be of polymer, glass, or silicon, or may comprise thin layers such as those used in microtechnology.
  • the plates of the same cell can be identical or different in nature. They can be constituted by a combination of materials, certain of the materials constituting them also being able to participate in the constitution of the magnetic means.
  • the plates may be rigid or not.
  • the displacement of the magnetic liquid or of the contained non-magnetic liquid may be facilitated by controlling the hydrophobic nature of the internal surfaces of the plates, by the control of the nature of its surfaces, for example be depositing a thin layer of an appropriate material or by creating a micro-structured roughness.
  • the inlets and outlets of the cells can be connected to other, coplanar or superposed, cells or to a reservoir of magnetic liquid, permitting complex microfluidic devices to be implemented in three dimensions.
  • two cells may be superposed, their separation being constituted by a plate common to the two cells and capable of being pierced by holes connecting these two cells.
  • the inlets and outlets of the cells can be capillaries, pipette cones, or any other assembly generally used in microfluidics.
  • the displacement of the contained liquid can be effected in two dimensions and in any direction.
  • the invention permits a simplification of microfluidic technology (no engraving of microchannels, no movable solid parts in contact with the non-magnetic liquid) and thus greater reliability.
  • the liquid to be manipulated being contained by the magnetic liquid, there is no problem of evaporation, even for very small volumes.
  • the devices according to the invention permit the manipulation of liquids which do not have particular dielectric properties (case of electro-osmotic pumping).
  • FIG. 5 shows, seen from above, an embodiment of the cell of a device according to the invention.
  • This cell comprises an upper plate 31 of machined Plexiglas, 2 mm thick.
  • the lower plate not visible in the drawing, is a Hybriwell self-adhesive plastic film, generally used in optical microscopy, 170 ⁇ m thick, glued to the upper plate 31 by a peripheral glue joint 33 , 120 ⁇ m thick.
  • the size of the cell is 64 mm ⁇ 25.5 mm.
  • the facing surfaces of the lower and upper plates are treated to make them hydrophobic.
  • the cell of FIG. 5 comprises two inlets 32 and 34 and three outlets 35 , 36 and 37 of 400 ⁇ m diameter formed in the upper plate 31 , into which are glued capillaries (not shown) of external diameter 380 ⁇ m and internal diameter 250 ⁇ m.
  • the bars 38 and 39 create, for example, a channel between the inlet 32 and the outlet 36 .
  • the channel may align between the inlet 32 and the outlet 35 .
  • the channel may slide from the direction inlet 32 -outlet 36 to the direction inlet 34 -outlet 37 .
  • the non-magnetic liquid can be pushed into the inlet capillary and into the channel by a syringe installed in a syringe pusher.
  • FIG. 6 shows a circular pointer with a central inlet 45 and several peripheral outlets 46 formed on the upper plate 41 .
  • a sheet of magnetic liquid, not shown, is confined between the upper plate 41 and the lower plate 42 .
  • Disposed under the lower plate 42 are two mutually parallel magnetized bars 43 and 44 , the magnetization of which is perpendicular to the plane of the cell.
  • the magnetized bars 43 and 44 are conjointly movable in rotation around the axis of the central inlet 45 .
  • the conjoint rotation of the magnetized bars 43 and 44 permits the creation of a channel between the central inlet 45 and any one of the outlets 46 .
  • the device according to the invention can employ a matrix of individually addressable and/or switchable electromagnets.
  • This type of matrix permits a generic, possibly programmable, microfluidic component to be envisaged, which can be configured at will and in which walls of magnetic liquid can be manipulated to create channels of more or less complex form (serpentine, for example), pointers or injectors.
  • the walls of magnetic liquid can also be manipulated for displacing, mixing, or dividing drops of liquid.
  • the same device can fulfill one or more of the functions mentioned hereinabove and can be associated with functions of heating, of stimulation (electrical, optical, chemical or biological) or of detection.
  • a reagent may be injected there, or some or all of the contained liquid may be aspirated.
  • the contained liquid may also be brought directly beneath one or more electrodes, to apply an electrical stimulation to it.
  • the contained liquid may also be brought directly beneath a zone of controllable temperature (activation or inhibition of a chemical or biological reaction in a drop of reagent, for example).
  • an optical signal may be activated or detected, for example by fluorescence, through a window in the cell, transparent to a certain wavelength, or through an optical fiber.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
US10/450,553 2001-10-15 2002-10-14 Microfluidic device for the manipulation of a non-magnetic liquid Abandoned US20040076525A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR01113262 2001-10-15
FR0113262A FR2830777B1 (fr) 2001-10-15 2001-10-15 Dispositif micro-fluidique pour la manipulation d'un liquide non magnetique
PCT/FR2002/003511 WO2003033147A1 (fr) 2001-10-15 2002-10-14 Dispositif micro-fluidique pour la manipulation d'un liquide non magnetique.

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US20040076525A1 true US20040076525A1 (en) 2004-04-22

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US10/450,553 Abandoned US20040076525A1 (en) 2001-10-15 2002-10-14 Microfluidic device for the manipulation of a non-magnetic liquid

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US (1) US20040076525A1 (fr)
EP (1) EP1436085A1 (fr)
FR (1) FR2830777B1 (fr)
WO (1) WO2003033147A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060017703A1 (en) * 2004-07-23 2006-01-26 Fujitsu Component Limited Input apparatus
US20110104025A1 (en) * 2008-04-24 2011-05-05 Commiss. A L'energie Atom.Et Aux Energ. Alterna. Method for producing reconfigurable microchannels
CN103674813A (zh) * 2013-09-22 2014-03-26 中国科学院电子学研究所 基于微流控技术测量单个细胞杨氏模量的方法
US8689981B2 (en) 2009-04-10 2014-04-08 President And Fellows Of Harvard College Manipulation of particles in channels
CN104251810A (zh) * 2013-12-18 2014-12-31 中国科学院电子学研究所 同时表征单细胞杨氏模量和细胞膜比电容的系统
US11434882B2 (en) * 2017-01-23 2022-09-06 Université De Strasbourg Device and method for circulating liquids

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3648269A (en) * 1970-07-16 1972-03-07 Ferrofluidics Corp Magnetic fluid display device
US3972595A (en) * 1975-01-27 1976-08-03 International Business Machines Corporation Ferrofluid display device
US4007010A (en) * 1974-07-03 1977-02-08 Woodbridge Iii Richard G Blister plane apparatus for testing samples of fluid
US4928125A (en) * 1987-09-24 1990-05-22 Minolta Camera Kabushiki Kaisha Liquid drop ejection apparatus using a magnetic fluid
US5005639A (en) * 1988-03-24 1991-04-09 The United States Of America As Represented By The Secretary Of The Air Force Ferrofluid piston pump for use with heat pipes or the like
US6290894B1 (en) * 1999-03-24 2001-09-18 Ferrofluidics Corporation Ferrofluid sculpting apparatus
US6318970B1 (en) * 1998-03-12 2001-11-20 Micralyne Inc. Fluidic devices

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6408884B1 (en) * 1999-12-15 2002-06-25 University Of Washington Magnetically actuated fluid handling devices for microfluidic applications
CA2403278A1 (fr) * 2000-03-16 2001-09-20 Subramanian Venkat Shastri Dispositifs et procedes de microlaboratoire

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3648269A (en) * 1970-07-16 1972-03-07 Ferrofluidics Corp Magnetic fluid display device
US4007010A (en) * 1974-07-03 1977-02-08 Woodbridge Iii Richard G Blister plane apparatus for testing samples of fluid
US3972595A (en) * 1975-01-27 1976-08-03 International Business Machines Corporation Ferrofluid display device
US4928125A (en) * 1987-09-24 1990-05-22 Minolta Camera Kabushiki Kaisha Liquid drop ejection apparatus using a magnetic fluid
US5005639A (en) * 1988-03-24 1991-04-09 The United States Of America As Represented By The Secretary Of The Air Force Ferrofluid piston pump for use with heat pipes or the like
US6318970B1 (en) * 1998-03-12 2001-11-20 Micralyne Inc. Fluidic devices
US6290894B1 (en) * 1999-03-24 2001-09-18 Ferrofluidics Corporation Ferrofluid sculpting apparatus

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060017703A1 (en) * 2004-07-23 2006-01-26 Fujitsu Component Limited Input apparatus
US20110104025A1 (en) * 2008-04-24 2011-05-05 Commiss. A L'energie Atom.Et Aux Energ. Alterna. Method for producing reconfigurable microchannels
US8679423B2 (en) 2008-04-24 2014-03-25 Commissariat A L'energie Atomique Et Aux Energies Alternatives Method for producing reconfigurable microchannels
US8689981B2 (en) 2009-04-10 2014-04-08 President And Fellows Of Harvard College Manipulation of particles in channels
CN103674813A (zh) * 2013-09-22 2014-03-26 中国科学院电子学研究所 基于微流控技术测量单个细胞杨氏模量的方法
CN104251810A (zh) * 2013-12-18 2014-12-31 中国科学院电子学研究所 同时表征单细胞杨氏模量和细胞膜比电容的系统
US11434882B2 (en) * 2017-01-23 2022-09-06 Université De Strasbourg Device and method for circulating liquids

Also Published As

Publication number Publication date
EP1436085A1 (fr) 2004-07-14
FR2830777A1 (fr) 2003-04-18
FR2830777B1 (fr) 2003-12-05
WO2003033147A1 (fr) 2003-04-24

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