US20030176654A1 - Nucleic acid probes and method for detecting ureaplasma urealyticum - Google Patents

Nucleic acid probes and method for detecting ureaplasma urealyticum Download PDF

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US20030176654A1
US20030176654A1 US10/349,680 US34968003A US2003176654A1 US 20030176654 A1 US20030176654 A1 US 20030176654A1 US 34968003 A US34968003 A US 34968003A US 2003176654 A1 US2003176654 A1 US 2003176654A1
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dna
ureaplasma urealyticum
nucleic acid
urealyticum
ureaplasma
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Gail Cassell
Ellson Chen
Jennifer Glass
John Glass
Cheryl Heiner
Elliot Lefkowitz
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UAB Research Foundation
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Publication of US20030176654A1 publication Critical patent/US20030176654A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Definitions

  • the present invention relates to the determination of the complete DNA sequence of Ureaplasma urealyticum (Uu) and to the use of novel genes and sequences as probes and primers for assays for use in the detection and/or quantification of Uu in a sample.
  • Uu Ureaplasma urealyticum
  • Ureaplasma urealyticun is a Mycoplasma which was first discovered in men with nongonococcal urethritis (NGU) in 1954. Approximately two-thirds of adults have Uu as part of their normal flora. Uu has been associated with and suspected as a pathogen in adverse pregnancy outcomes such as chorioamnionitis, intrauterine infection, and premature births. Uu has also been diagnosed as the causative agent of neonatal diseases such as pneumonia, meningitis, and sepsis. Uu has also been isolated in certain patients suffering from suppurative arthritis, especially those having hypogammaglobulinemia.
  • the biology of Uu which is a member of the Mycoplasma family, is unique.
  • the Mycoplasma family is a family of wall-less bacteria which has descended from low G+C Gram positive bacteria.
  • Ureaplasma urealyticum infections are commonly asymptomatic, it is important to have specific and sensitive methods for detecting their presence in a patient.
  • Mycoplasmas including Ureaplasma urealyticum are somewhat atypical organisms and are difficult and are complex to culture. It is difficult for clinical laboratories to perform culture isolation of Mycoplasmas and consequently there are no relatively easy and inexpensive methods for diagnosing the presence of this bacterium.
  • U.S. Pat. No. 5,843,667 to Weisburg et al. discloses various nucleic acid sequences which are capable of hybridizing to rRNA and rDNA of Mycoplasma etiological agents including Ureaplasma urealyticum .
  • the nucleic acid probes disclosed in the Weisburg et al. patent specifically hybridize to 16S rRNA or 16S rDNA of Ureaplasma urealyticum .
  • Ureaplasma urealyticum involving in vitro nucleic acid amplification by contacting Ureaplasma urealyticum target nucleic acids with an oligonucleotide fragment consisting of a contiguous nucleotide of Ureaplasma urealyticum DNA inserted into the plasmid pCU3900 having ATCC Accession No. 97424.
  • U.S. Pat. Nos. 5,843,667 nor 5,728,522 disclose the entire DNA sequence of Ureaplasma urealyticum serovar 3 and, in fact, only disclose small DNA and/or RNA sequences from Ureaplasma urealyticum.
  • a method of detecting a nucleic acid sequence in Ureaplasma urealyticum serovar 3 includes the steps of isolating a specimen containing nucleic acid; and analyzing the specimen with an assay such as in situ hybridization, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification, 5′ nuclease assay (TaqMan PCR), and DNA-chip analysis using the unique nucleic acid sequence SEQ ID Nos:1-181.
  • an assay such as in situ hybridization, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification, 5′ nuclease assay (TaqMan PCR), and DNA-chip analysis using the unique nucleic acid sequence SEQ ID Nos:1-181.
  • the present invention provides the sequence of the genome of the bacterium Ureaplasma urealyticum serovar 3 (Uu).
  • Uu is an opportunistic pathogen of the human urogenital tract that is a significant cause of adverse pregnancy outcome, neonatal disease, and suppurative arthritis.
  • Uu contains a single circular chromosome having 751,719 base pairs designated SEQ ID No:182. Of these base pairs, only 25.5% of the bases are G or C.
  • the Uu chromosome codes for approximately 600 genes.
  • Ureaplasmas use an unusual genetic code in which TGA codes for tryptophan instead of for translation termination. Although 62 codons for amino acid are represented in the Uu genome, only 30 tRNAs are coded for by the Uu genome. There are only two rRNA operons.
  • the present invention also consists of purified, isolated, and cloned nucleic acid sequences encoding novel genes designated SEQ ID Nos:1-181.
  • the nucleic acid can be genomic DNA, cDNA, or mRNA.
  • the invention further provides purified protein sequences as encoded by the novel Uu genes and analogs and mutations thereof.
  • the present invention further includes the recombinant proteins encoded by the genes. These recombinant proteins are isolated and purified by techniques known to those skilled in the art.
  • analog is used to define a compound or molecule which will be generally at least 70% homologous over any portion that is functionally relevant. In more preferred embodiments, the homology will be at least 80% and can approach 95% homology to the native protein.
  • the amino acid sequence of any analog may differ from that of the native protein when at least one residue is deleted, inserted, or substituted but the protein remains functional. Differences in glycosylation can provide analogs.
  • nucleotide is used to define a subunit of nucleic acid consisting of a phosphate group, a 5′ carbon sugar, and a nitrogen containing base.
  • the 5′ carbon sugar is a 2-deoxyribose.
  • the 5′ carbon sugar is a ribose.
  • oligonucleotide is defined as a nucleotide polymer (at least two nucleotides linked by a phosphodiester bond).
  • nucleic acid probe and “primer” are used to define a single stranded nucleic acid sequence that will combine with a complementary single stranded target nucleic acid sequence to form a double-stranded molecule or hybrid.
  • primer the hybrid can be used to initiate replication such as with PCR.
  • hybrid is used to define the complex formed between two single stranded nucleic acid sequences by standard base pairing.
  • hybridization defines the process by which two complementary strands of nucleic acids combine to form a double stranded molecule or hybrid.
  • stringency is used to define the temperature and solvent composition existing during hybridization and the subsequent processing steps at which a hybrid comprised of two complementary nucleic acid sequences will form. Stringency also defines the amount of homology, the conditions necessary, and the stability of hybrids formed between target sequences and nontarget sequences.
  • the present invention also provides vectors comprising an expression control sequence operatively linked to the nucleic acid sequences of the Uu genes and portions thereof as well as mutant sequences.
  • the present invention further provides host cells, selected from suitable eukaryotic and prokaryotic cells, which are transformed with these vectors.
  • Vectors are known or can be constructed by those skilled in the art and should contain all expression elements necessary to achieve the desired transcription of the sequences. Other beneficial characteristics can also be contained within the vector such as mechanisms for recovery of the nucleic acids in a different form.
  • Phagemids are a specific example of such beneficial vectors because they can be used either as plasmids or bacteriophage vectors. Examples of other vectors include viruses such as bacteriophages, baculoviruses and retroviruses, DNA viruses, cosmids, plasmids and other recombination vectors.
  • the vectors can also contain elements for use in either prokaryotic or eukaryotic host systems. One of ordinary skill in the art will know which host systems are compatible with a particular vector.
  • the vectors can be introduced into cells or tissues by any one of a variety of known methods within the art. Such methods can be found generally described in Sambrook et al., Molecular Cloning: A Laboratory Manual , Cold Springs Harbor Laboratory, New York (1992). Also, nucleic acids can be introduced by, for example, stable or transient transfection, lipofection, electroporation and infection with recombinant viral vectors. Introduction of nucleic acids by infection offers several advantages over the other listed methods. Higher efficiency can be obtained due to their infectious nature. See also U.S. Pat. Nos. 5,487,992 and 5,464,764. Moreover, viruses are very specialized and typically infect and propagate in specific cell types. Thus, their natural specificity can be used to target the vectors to a specific cell type in vivo or within a tissue or mixed culture of cells. Viral vectors can also be modified with specific receptors or ligands to alter target specificity through receptor mediated events.
  • vectors containing anti-sense nucleic acids can be employed to express protein or anti-sense messages to reduce the expression of the target nucleic acid and therefore its activity.
  • a method for diagnosing and detecting Uu in a subject is also provided.
  • Carrier detection is especially important in diagnosing and treating those individuals or patients which may be infected with Uu. Identifying those infected by the presence of Uu specific nucleic acid sequences can lead to earlier diagnosis and treatment.
  • the methods for diagnosing and detecting Uu in a subject generally comprise the steps of obtaining a sample from a test subject, isolating the appropriate test material from the sample and assaying the sample for the target nucleic acid sequences or gene products.
  • the sample can be tissue or bodily fluids from which genetic material and/or proteins are isolated using methods standard in the art.
  • DNA can be isolated from fluid or cells obtained from a vaginal swab.
  • the method of Uu detection is carried out by first obtaining a sample of either cells or bodily fluid from a subject.
  • Convenient methods for obtaining a cellular sample can include swabbing or fluid collection.
  • Crude DNA samples can be isolated from the cells (or alternatively proteins isolated) by techniques well known to those skilled in the art.
  • This isolated target DNA is then used for PCR analysis (or alternatively, Western blot analysis for proteins) with appropriate primers derived from selected Uu gene sequences such as SEQ ID Nos:1-173 by techniques well known in the art.
  • the PCR product would then be tested for the presence of Uu specific sequences or variations thereof in order to diagnose and detect Uu in the subject.
  • the specimen can be assayed for polypeptides/proteins by immunohistochemical and immunocytochemical staining, ELISA, RIA, immunoblots, Western blotting, immunoprecipitation, functional assays and protein truncation tests. In preferred embodiments, Western blotting, functional assays, and protein truncation tests will be used.
  • mRNA complementary to the target nucleic acid sequences can be assayed by in situ hybridization, Northern blotting and reverse transcriptase-polymerase chain reaction. Nucleic acid sequences can be identified by in situ hybridization, Southern blotting, single strand conformational polymorphism, PCR amplification and DNA-chip analysis using specific primers.
  • ELISA assays are well known to those skilled in the art. Both polyclonal and monoclonal antibodies can be used in the assays. Where appropriate, other immunoassays, such as radioimmunoassays (RIA) can be used as are known to those in the art. Available immunoassays are extensively described in the patent and scientific literature. See, for example, U.S. Pat. Nos.
  • Uu gene sequences SEQ ID Nos:1-173 can be expressed using protein expression technology such as generally described in Sambrook et al., 1992.
  • Those Uu proteins expressed using recombinant DNA technology can be used in ELISA or Western blot assays for serological based detection of Uu in patient samples.
  • the aforementioned Uu proteins can also be used to generate monoclonal antibodies that could be used in the detection of Uu.
  • oligomer probes are labeled with radioisotopes such as 32 p or 35 S (Sambrook, 1992) which can be detected by methods well known in the art such as autoradiography. Oligomer probes can also be labeled with non-radioactive methods such as chemiluminescent materials which can be detected by autoradiography (Sambrook, 1992).
  • Labeling can be accomplished by mechanisms well known in the art such as end labeling (Sambrook, 1992), chemical labeling, or by hybridization with another labeled oligonucleotide. These methods of labeling and detection are provided merely as examples and are not meant to provide a complete and exhaustive list of all of the methods known in the art.
  • the introduction of a label for detection purposes can be accomplished by attaching the label to the probe prior to hybridization.
  • An alternative method for practicing the method of the present invention includes the step of binding the target DNA to a solid support prior to the application of the probe.
  • the solid support can be any material capable of binding the target DNA, such as beads or a membranous material such as nitrocellulose or nylon. After the target DNA is bound to the solid support, the probe oligomers are applied.
  • the present invention also provides a kit for diagnosis and detection of Uu in a subject.
  • the kit can include a molecular probe complementary to specific genetic sequences found only in Uu and suitable labels for detecting hybridization of the molecular probe and the specific Uu gene thereby indicating the presence of Uu.
  • the molecular probe has a DNA sequence complementary to the targeted Uu sequence.
  • the kit can contain reagents and antibodies for detection of specific Uu proteins.
  • Ureaplasma urealyticum serovar 3 reference strain was obtained from E. A. Freundt (Institute of Medical Microbiology, University of Aarhus, Aarhus, Denmark). Uu was grown in 10B medium until the media pH became alkaline, the cells were concentrated in a phosphate buffered saline solution by a combination of filtration and high speed centrifugation. Uu genomic DNA was extracted from the cell suspension using an Invitrogen EZ DNA kit according to the manufacturer's instructions for isolating DNA from Gram positive bacteria.
  • the Uu genomic sequence was obtained by a process developed for this project that is referred to as CROSS (Complete Random+Ordered Shotgun Sequencing).
  • CROSS Complete Random+Ordered Shotgun Sequencing
  • three different clonal libraries were prepared.
  • Uu DNA was partially digested using the restriction enzyme Sau 3A and fragments containing between 7,000 and 11,000 base pairs were ligated into a Novagen Bluestar lambda vector according to the Novagen Lambda Bluestar Vector System instructions.
  • Individual phage clones grown in E. coli were collected in to a TM solution to stabilize the phage.
  • the inserts contained in more than 1,500 individual Uu-lambda bacteriophage clones were amplified using XL-PCR according to the manufacturer's instructions (Perkin Elmer XL-PCR kit) using universal T3 and T7 primers.
  • the ends of the XL-PCR amplicons were sequenced by performing reactions in a Applied Biosystems 877 Catalyst Robotic Workstation and analyzing the reactants using either an Applied Biosystems 373 or 377 Prism DNA Sequencing apparatus.
  • Two small insert libraries containing Uu DNA inserts were made by ligating Uu fragments sheared to between 1,000 and 2,000 base pairs using nebulization or digested using either Rsa I, Alu I or San 3A I to between 1,000 and 2,000 base pairs. Inserts were ligated into the cloning vector pUC18. The plasmids were then ligated into E. coli . Sequencing templates were generated from bacteria containing Uu inserts in plasmids by the method of colony PCR.
  • SEQ ID Nos:1-173 The unique genes isolated, purified, and cloned which were derived from Ureaplasma urealyticum serovar 3. These sequences, designated SEQ ID Nos:1-173, can be specifically utilized as probes or primers in the detection and diagnosis of Uu infection in a subject by the methods described above.
  • SEQ ID Nos:174-181 designate genes associated with the urease complex of Ureaplasma urealyticum . In terms of developing or designing an antibiotic specifically targeted at Ureaplasma urealyticum , the most logical genetic target or gene product target would be some component associated with the urease gene complex.

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Abstract

A method of detecting a nucleic acid sequence in Ureaplasma urealyticum serovar 3 includes the steps of isolating a specimen containing nucleic acid; and analyzing the specimen with an assay such as in situ hybridization, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification, 5′ nuclease assay (TaqMan PCR), and DNA-chip analysis using the nucleic acid sequences SEQ ID Nos:1-181.

Description

    RELATED APPLICATIONS
  • This application is a divisional of U.S. patent application Ser. No. 09/601,198 filed Dec. 8, 2000, which is the U.S. national phase of PCT/US99/01972 filed Jan. 29, 1999, which claims priority of U.S. Provisional Application Ser. No. 60/073,189 filed Jan. 30, 1998.[0001]
    • GRANT REFERENCE
  • [0002] The subject invention was made with government support under a grant from the National Institutes of Health, Grant No. NIH-AI28279. The government has certain rights in the invention.
    • TECHNICAL FIELD
  • The present invention relates to the determination of the complete DNA sequence of [0003] Ureaplasma urealyticum (Uu) and to the use of novel genes and sequences as probes and primers for assays for use in the detection and/or quantification of Uu in a sample.
    • BACKGROUND OF THE INVENTION
  • [0004] Ureaplasma urealyticun (Uu) is a Mycoplasma which was first discovered in men with nongonococcal urethritis (NGU) in 1954. Approximately two-thirds of adults have Uu as part of their normal flora. Uu has been associated with and suspected as a pathogen in adverse pregnancy outcomes such as chorioamnionitis, intrauterine infection, and premature births. Uu has also been diagnosed as the causative agent of neonatal diseases such as pneumonia, meningitis, and sepsis. Uu has also been isolated in certain patients suffering from suppurative arthritis, especially those having hypogammaglobulinemia.
  • The primary mechanism of transmission of Uu is by sexual contact which can then be transmitted to neonates born to infected mothers. [0005]
  • The biology of Uu, which is a member of the Mycoplasma family, is unique. The Mycoplasma family is a family of wall-less bacteria which has descended from low G+C Gram positive bacteria. The Mycoplasma are included among the smallest free-living cells known. Additionally, the Mycoplasma use an alternate genetic code wherein the codon UGA=tryptophan (trp) rather than a stop or termination codon. Additionally, the Mycoplasma are biochemically different in that they possess no TCA cycle and most Mycoplasma require cholesterol for growth. [0006]
  • [0007] Ureaplasma urealyticum infections are commonly asymptomatic, it is important to have specific and sensitive methods for detecting their presence in a patient. Mycoplasmas including Ureaplasma urealyticum are somewhat atypical organisms and are difficult and are complex to culture. It is difficult for clinical laboratories to perform culture isolation of Mycoplasmas and consequently there are no relatively easy and inexpensive methods for diagnosing the presence of this bacterium.
  • Genetic probes and detection methods for detecting Mycoplasmas including [0008] Ureaplasma urealyticum have been developed. U.S. Pat. No. 5,843,667 to Weisburg et al. discloses various nucleic acid sequences which are capable of hybridizing to rRNA and rDNA of Mycoplasma etiological agents including Ureaplasma urealyticum. The nucleic acid probes disclosed in the Weisburg et al. patent specifically hybridize to 16S rRNA or 16S rDNA of Ureaplasma urealyticum. Similarly, U.S. Pat. No. 5,728,522 to Del Vecchio et al. discloses a method for detecting Ureaplasma urealyticum involving in vitro nucleic acid amplification by contacting Ureaplasma urealyticum target nucleic acids with an oligonucleotide fragment consisting of a contiguous nucleotide of Ureaplasma urealyticum DNA inserted into the plasmid pCU3900 having ATCC Accession No. 97424.
  • Neither U.S. Pat. Nos. 5,843,667 nor 5,728,522 disclose the entire DNA sequence of [0009] Ureaplasma urealyticum serovar 3 and, in fact, only disclose small DNA and/or RNA sequences from Ureaplasma urealyticum.
  • Therefore, in order to better understand the nature and effects of [0010] Ureaplasmna urealyticum, as well as to more accurately and consistently detect and diagnose the presence of Ureaplasma urealyticum in a potential carrier and to better develop antibiotic drugs specifically effective against Ureaplasma urealyticum, which, consequently, has no current antibiotic directed specifically against it, it would be advantageous to isolate and determine the gene sequences and functions which are unique to Ureaplasma urealyticum and utilize these sequences as a basis for detecting Ureaplasma urealyticum in a patient and thereby be able to more effectively treat those patients infected with Ureaplasma urealyticum as well as to develop new and improved drug therapies against Ureaplasma urealyticum.
    • SUMMARY OF THE INVENTION
  • A method of detecting a nucleic acid sequence in [0011] Ureaplasma urealyticum serovar 3 includes the steps of isolating a specimen containing nucleic acid; and analyzing the specimen with an assay such as in situ hybridization, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification, 5′ nuclease assay (TaqMan PCR), and DNA-chip analysis using the unique nucleic acid sequence SEQ ID Nos:1-181.
    •  DETAILED DESCRIPTION OF THE INVENTION
  • The present invention provides the sequence of the genome of the bacterium [0012] Ureaplasma urealyticum serovar 3 (Uu). Uu is an opportunistic pathogen of the human urogenital tract that is a significant cause of adverse pregnancy outcome, neonatal disease, and suppurative arthritis. Uu contains a single circular chromosome having 751,719 base pairs designated SEQ ID No:182. Of these base pairs, only 25.5% of the bases are G or C. The Uu chromosome codes for approximately 600 genes. As discussed above, Ureaplasmas use an unusual genetic code in which TGA codes for tryptophan instead of for translation termination. Although 62 codons for amino acid are represented in the Uu genome, only 30 tRNAs are coded for by the Uu genome. There are only two rRNA operons.
  • The present invention also consists of purified, isolated, and cloned nucleic acid sequences encoding novel genes designated SEQ ID Nos:1-181. The nucleic acid can be genomic DNA, cDNA, or mRNA. [0013]
  • The invention further provides purified protein sequences as encoded by the novel Uu genes and analogs and mutations thereof. [0014]
  • The present invention further includes the recombinant proteins encoded by the genes. These recombinant proteins are isolated and purified by techniques known to those skilled in the art. [0015]
  • As used herein, the term “analog” is used to define a compound or molecule which will be generally at least 70% homologous over any portion that is functionally relevant. In more preferred embodiments, the homology will be at least 80% and can approach 95% homology to the native protein. The amino acid sequence of any analog may differ from that of the native protein when at least one residue is deleted, inserted, or substituted but the protein remains functional. Differences in glycosylation can provide analogs. [0016]
  • As defined herein, the term “nucleotide” is used to define a subunit of nucleic acid consisting of a phosphate group, a 5′ carbon sugar, and a nitrogen containing base. In DNA, the 5′ carbon sugar is a 2-deoxyribose. For RNA, the 5′ carbon sugar is a ribose. [0017]
  • As used herein, the term “oligonucleotide” is defined as a nucleotide polymer (at least two nucleotides linked by a phosphodiester bond). [0018]
  • As defined herein, the terms “nucleic acid probe” and “primer” are used to define a single stranded nucleic acid sequence that will combine with a complementary single stranded target nucleic acid sequence to form a double-stranded molecule or hybrid. In the case of the primer, the hybrid can be used to initiate replication such as with PCR. [0019]
  • As used herein, the term “hybrid” is used to define the complex formed between two single stranded nucleic acid sequences by standard base pairing. [0020]
  • As used herein, the term “hybridization” defines the process by which two complementary strands of nucleic acids combine to form a double stranded molecule or hybrid. [0021]
  • As used herein, the term “stringency” is used to define the temperature and solvent composition existing during hybridization and the subsequent processing steps at which a hybrid comprised of two complementary nucleic acid sequences will form. Stringency also defines the amount of homology, the conditions necessary, and the stability of hybrids formed between target sequences and nontarget sequences. [0022]
  • The present invention also provides vectors comprising an expression control sequence operatively linked to the nucleic acid sequences of the Uu genes and portions thereof as well as mutant sequences. The present invention further provides host cells, selected from suitable eukaryotic and prokaryotic cells, which are transformed with these vectors. [0023]
  • Using the present invention, it is possible to transform host cells including [0024] E. coli, using the appropriate vectors so that they carry recombinant DNA sequences derived from Uu genes. Such transformed cells allow the study of the function and regulation of the particular genes. Use of recombinantly transformed host cells allows for the study of the mechanisms of Uu gene function and, in particular, it will allow for the study of gene function and can be used in the development of antibiotics or other drug therapies useful against Uu.
  • Vectors are known or can be constructed by those skilled in the art and should contain all expression elements necessary to achieve the desired transcription of the sequences. Other beneficial characteristics can also be contained within the vector such as mechanisms for recovery of the nucleic acids in a different form. Phagemids are a specific example of such beneficial vectors because they can be used either as plasmids or bacteriophage vectors. Examples of other vectors include viruses such as bacteriophages, baculoviruses and retroviruses, DNA viruses, cosmids, plasmids and other recombination vectors. The vectors can also contain elements for use in either prokaryotic or eukaryotic host systems. One of ordinary skill in the art will know which host systems are compatible with a particular vector. [0025]
  • The vectors can be introduced into cells or tissues by any one of a variety of known methods within the art. Such methods can be found generally described in Sambrook et al., [0026] Molecular Cloning: A Laboratory Manual, Cold Springs Harbor Laboratory, New York (1992). Also, nucleic acids can be introduced by, for example, stable or transient transfection, lipofection, electroporation and infection with recombinant viral vectors. Introduction of nucleic acids by infection offers several advantages over the other listed methods. Higher efficiency can be obtained due to their infectious nature. See also U.S. Pat. Nos. 5,487,992 and 5,464,764. Moreover, viruses are very specialized and typically infect and propagate in specific cell types. Thus, their natural specificity can be used to target the vectors to a specific cell type in vivo or within a tissue or mixed culture of cells. Viral vectors can also be modified with specific receptors or ligands to alter target specificity through receptor mediated events.
  • Recombinant methods known in the art can also be used to achieve the sense, anti-sense or triplex inhibition of target nucleic acid. For example, vectors containing anti-sense nucleic acids can be employed to express protein or anti-sense messages to reduce the expression of the target nucleic acid and therefore its activity. [0027]
  • According to the present invention, there is also provided a method for diagnosing and detecting Uu in a subject. Carrier detection is especially important in diagnosing and treating those individuals or patients which may be infected with Uu. Identifying those infected by the presence of Uu specific nucleic acid sequences can lead to earlier diagnosis and treatment. [0028]
  • The methods for diagnosing and detecting Uu in a subject generally comprise the steps of obtaining a sample from a test subject, isolating the appropriate test material from the sample and assaying the sample for the target nucleic acid sequences or gene products. The sample can be tissue or bodily fluids from which genetic material and/or proteins are isolated using methods standard in the art. For example, DNA can be isolated from fluid or cells obtained from a vaginal swab. [0029]
  • More specifically, the method of Uu detection is carried out by first obtaining a sample of either cells or bodily fluid from a subject. Convenient methods for obtaining a cellular sample can include swabbing or fluid collection. Crude DNA samples can be isolated from the cells (or alternatively proteins isolated) by techniques well known to those skilled in the art. This isolated target DNA is then used for PCR analysis (or alternatively, Western blot analysis for proteins) with appropriate primers derived from selected Uu gene sequences such as SEQ ID Nos:1-173 by techniques well known in the art. The PCR product would then be tested for the presence of Uu specific sequences or variations thereof in order to diagnose and detect Uu in the subject. [0030]
  • The specimen can be assayed for polypeptides/proteins by immunohistochemical and immunocytochemical staining, ELISA, RIA, immunoblots, Western blotting, immunoprecipitation, functional assays and protein truncation tests. In preferred embodiments, Western blotting, functional assays, and protein truncation tests will be used. mRNA complementary to the target nucleic acid sequences can be assayed by in situ hybridization, Northern blotting and reverse transcriptase-polymerase chain reaction. Nucleic acid sequences can be identified by in situ hybridization, Southern blotting, single strand conformational polymorphism, PCR amplification and DNA-chip analysis using specific primers. [0031]
  • ELISA assays are well known to those skilled in the art. Both polyclonal and monoclonal antibodies can be used in the assays. Where appropriate, other immunoassays, such as radioimmunoassays (RIA) can be used as are known to those in the art. Available immunoassays are extensively described in the patent and scientific literature. See, for example, U.S. Pat. Nos. 3,791,932; 3,839,153; 3,850,752; 3,850,578; 3,853,987; 3,867,517; 3,879,262; 3,901,654; 3,935,074; 3,984,533; 3,996,345; 4,034,074; 4,098,876; 4,879,219; 5,011,771; and 5,281,521 as well as Sambrook et al., 1992. The Uu gene sequences SEQ ID Nos:1-173 can be expressed using protein expression technology such as generally described in Sambrook et al., 1992. Those Uu proteins expressed using recombinant DNA technology can be used in ELISA or Western blot assays for serological based detection of Uu in patient samples. The aforementioned Uu proteins can also be used to generate monoclonal antibodies that could be used in the detection of Uu. [0032]
  • In order to use the method of the present invention for diagnostic applications, it is advantageous to include a mechanism for identifying the presence or absence of target polynucleotide sequences (or alternatively proteins). In many hybridization based diagnostic or experimental procedures, a label or tag is used to detect or visualize for the presence or absence of a particular polynucleotide sequence. Typically, oligomer probes are labeled with radioisotopes such as [0033] 32p or 35S (Sambrook, 1992) which can be detected by methods well known in the art such as autoradiography. Oligomer probes can also be labeled with non-radioactive methods such as chemiluminescent materials which can be detected by autoradiography (Sambrook, 1992). Also, enzyme-substrate based labeling and detection methods can be used. Labeling can be accomplished by mechanisms well known in the art such as end labeling (Sambrook, 1992), chemical labeling, or by hybridization with another labeled oligonucleotide. These methods of labeling and detection are provided merely as examples and are not meant to provide a complete and exhaustive list of all of the methods known in the art.
  • The introduction of a label for detection purposes can be accomplished by attaching the label to the probe prior to hybridization. [0034]
  • An alternative method for practicing the method of the present invention includes the step of binding the target DNA to a solid support prior to the application of the probe. The solid support can be any material capable of binding the target DNA, such as beads or a membranous material such as nitrocellulose or nylon. After the target DNA is bound to the solid support, the probe oligomers are applied. [0035]
  • The present invention also provides a kit for diagnosis and detection of Uu in a subject. The kit can include a molecular probe complementary to specific genetic sequences found only in Uu and suitable labels for detecting hybridization of the molecular probe and the specific Uu gene thereby indicating the presence of Uu. The molecular probe has a DNA sequence complementary to the targeted Uu sequence. Alternatively, the kit can contain reagents and antibodies for detection of specific Uu proteins. The above discussion provides the factual basis for the use and identification of Uu, Uu genes, and Uu gene products and the identification and detection of those infected with Uu. [0036]
    • MATERIALS AND METHODS
  • General Methods in Molecular Biology: [0037]
  • Standard molecular biology techniques known in the art and not specifically described were generally followed as in Sambrook et al., [0038] Molecular Cloning: A Laboratory Manual, Cold Springs Harbor Laboratory, New York (1992).
  • [0039] Ureaplasma urealyticum serovar 3 reference strain was obtained from E. A. Freundt (Institute of Medical Microbiology, University of Aarhus, Aarhus, Denmark). Uu was grown in 10B medium until the media pH became alkaline, the cells were concentrated in a phosphate buffered saline solution by a combination of filtration and high speed centrifugation. Uu genomic DNA was extracted from the cell suspension using an Invitrogen EZ DNA kit according to the manufacturer's instructions for isolating DNA from Gram positive bacteria.
  • The Uu genomic sequence was obtained by a process developed for this project that is referred to as CROSS (Complete Random+Ordered Shotgun Sequencing). In preparation for the complete random phase of the sequence analysis three different clonal libraries were prepared. To make a large insert library in lambda bacteriophage, Uu DNA was partially digested using the restriction enzyme Sau 3A and fragments containing between 7,000 and 11,000 base pairs were ligated into a Novagen Bluestar lambda vector according to the Novagen Lambda Bluestar Vector System instructions. Individual phage clones grown in [0040] E. coli were collected in to a TM solution to stabilize the phage. The inserts contained in more than 1,500 individual Uu-lambda bacteriophage clones were amplified using XL-PCR according to the manufacturer's instructions (Perkin Elmer XL-PCR kit) using universal T3 and T7 primers. The ends of the XL-PCR amplicons were sequenced by performing reactions in a Applied Biosystems 877 Catalyst Robotic Workstation and analyzing the reactants using either an Applied Biosystems 373 or 377 Prism DNA Sequencing apparatus. Two small insert libraries containing Uu DNA inserts were made by ligating Uu fragments sheared to between 1,000 and 2,000 base pairs using nebulization or digested using either Rsa I, Alu I or San 3A I to between 1,000 and 2,000 base pairs. Inserts were ligated into the cloning vector pUC18. The plasmids were then ligated into E. coli. Sequencing templates were generated from bacteria containing Uu inserts in plasmids by the method of colony PCR. The ends of those DNA templates were then sequenced using M13-40 forward and reverse primers by performing reactions in a Applied Biosystems 877 Catalyst Robotic Workstation and analyzing the reactants using either an Applied Biosystems 373 or 377 Prism DNA Sequencing apparatus. After obtaining approximately 2,400 DNA sequencing reads from the large insert lambda bacteriophage library and 7,600 DNA sequencing reads from the small insert plasmid libraries, the data were assembled using the DNA sequence assembly software Autoassembler 1.4 (PE-Applied Biosystems). Gaps remaining in the genomic sequence were filled by an ordered phase which was a mix of “genomic walking” and “ordered shotgun sequencing”. Those gaps in the sequence that were small were closed by either making a PCR amplicon that crossed the gap to use as a DNA sequencing template, or were closed by sequencing using whole genomic DNA as a template (the last method was developed as part of the Uu genome sequencing project, and is described in Heiner C. R., K. L. Hunkapiller, S. Chen, J. I. Glass, and E. Y. Chen. Sequencing multimegabase-template DNA with BigDye™ terminator chemistry PCR Methods & Applications. 8(5):557-6 (1998). Large gaps or areas containing many small gaps were completed using a method developed for “ordered shotgun sequencing” (Chen, E. Y., Schlessinger, D. and Kere, J. Ordered shotgun sequencing, a strategy for integrated mapping and sequencing of YAC clones. Genomics 17, 651-656 (1993);Chen, C., Su, Y., Baybayan, P., Siruno, A., Nagaraja, R., Mezzarella, R., Schlessinger, D, and Chen, E. Y. Ordered Shotgun Sequencing of a 135 kb Xq25 YAC containing ANT-2 and four possible genes, including three confirmed by EST matches. Nucleic Acids Res. 24, 4034-4041 (1996).) Briefly, a XL-PCR amplified insert from a large Uu insert bacteriophage clone that spanned the gap or region of low sequence quality was sonicated to generate Uu genome fragments between 1,000 and 2,000 base pairs in length. Using colony PCR sequencing as described earlier in this paragraph, 48 clones containing Uu inserts were sequenced and the new data was added to the assembly. All the assembled sequences were edited to remove low quality data and correct incorrect base calls made by the Applied Biosystems 373 and 377 Prism DNA sequencing software. Each of the 751,719 bases in the final assembly was sequenced by at least two different high quality sequencing reactions.
  • Data checking and functional annotation of the Uu sequence was preformed using a system based upon compiling the results from Genemark searches (Borodovsky, M., McIninch, J., Koonin, E., Rudd, K., Medigue, C. and A. Danchin. 1995. Detection of New Genes in the Bacterial Genome Using Markov Models for Three Gene Classes. Nucleic Acids Research, 23, 3554-3562.) for potential protein-coding genes, followed by BLAST sequence homology searches (Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W. & Lipman, D. J. (1997) “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.” Nucleic Acids Res. 25:3389-3402) to determine matches to existing genes and identify genes unique to Uu. This information was then loaded into a Microsoft SQL Server database that we have developed that contains all Uu sequence and annotation information. The front-end for this database is a web page that directly accesses the SQL Server data, and allows users to develop individualized queries that can be constructed by setting desired options on a web form. This system is not only used to query the similarity and alignment data, but is also used in the direct annotation of the sequence. Web forms have been developed that allow us to directly enter coordinate data along with gene identification and similarity data into our annotation database. [0041]
  • The unique genes isolated, purified, and cloned which were derived from [0042] Ureaplasma urealyticum serovar 3. These sequences, designated SEQ ID Nos:1-173, can be specifically utilized as probes or primers in the detection and diagnosis of Uu infection in a subject by the methods described above. SEQ ID Nos:174-181 designate genes associated with the urease complex of Ureaplasma urealyticum. In terms of developing or designing an antibiotic specifically targeted at Ureaplasma urealyticum, the most logical genetic target or gene product target would be some component associated with the urease gene complex.
  • Throughout this application, various publications and patents are referenced by citation or number. Full citations for the publications referenced are listed below. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains. [0043]
  • The invention has been described in an illustrative manner, and it is to be understood that the terminology which has been used is intended to be in the nature of words of description rather than of limitation. [0044]
  • Obviously, many modifications and variations of the present invention are possible in light of the above teachings. It is, therefore, to be understood that within the scope of the appended claims, the invention may be practiced otherwise than as specifically described. [0045]
  • 1 181 1 561 DNA Ureaplasma urealyticum 1 atgttaaata ttttaaataa tgtatctaat tcttcactat attcagccgc ttcaaatgct 60 actgcgcaaa ctggttcaaa tttgatcaat gatctagttc cagaaacatt aaccgcttca 120 ggaattagta tcgctatttc tgtttttagt gttataggta cgatcgttat tgctttgagt 180 gtattgccac aaacaattaa aactttacgt gaaaaagata cagcttcatt aagtttatta 240 ctattcttgc ttaatggtat tgctacagcc tttttaactc tatacggtat tggacttgtt 300 acagttcatc caaattcatt ttcattctta gtggatatta aaaacggaat gttcatttat 360 aatagagaag agtgagttgc tggatactta atctgcggta tcttcttaat tatgggtgaa 420 gcattatgtt cagtaacttc atttattgtt ctattctgca aagttaataa catgattaaa 480 gctaaaaaaa tgggaatgag cgaagaagaa tattatgaaa aacaaattaa accattccta 540 aaagtgaaag gagctaacta a 561 2 477 DNA Ureaplasma urealyticum 2 atgaatttca cttcattatt gcaagatggt atatatgaag ttggtaatgg tgcaatcgtt 60 actgaccaat caccatattt aggaattaca cctgattatc agggtgcata tggtttccca 120 acacaccctt gaggtatttt ctttcaagtt gttggagcta ttttagtttt tggtgcttat 180 ttacctgctg ttattaaagt actaatttca aaaagaactg aaaatttggc tattggtatg 240 tgaattattt caattgctgg tttaggatta ttagcgatat ttgcttgatt aggtgtttct 300 gtaaaccctg gaggatttat tcttgtagct ctaagtgaaa cactatcttg cattgcaagt 360 ataattgtgt ttgctttaaa aattgcaaat aaagctaaag ctaaagccgc tggtatgact 420 gaattagaat actgcaactt acactatcca attgttaaaa aattacctaa aagataa 477 3 1550 DNA Ureaplasma urealyticum 3 tataattgtg gaatcttaat tccatgtttt gcatagaatt cttttagacc gttgtacgta 60 ttttcagaat atccaccatc ttttactttt gctcctgcat aagataaaag caacccaatt 120 aatgcttgtt tttcatcatt tgatttagta ttatcccata tttctttaaa tttctttgaa 180 gatgtgttag aaatatatgt agatttggca acaggataga aataatatgt acctttagct 240 gatttataaa aagttccgcc atttactctt ggatcaatcg ttttattatt taataaagat 300 gcttcattat ctgtttcttt tttaacatct aaataaccat caacaactgg ttttttatca 360 agtgttttaa ataaatcatc attagtgatt ttattaacta attcatcata tgtgcttact 420 ttatcacttt gatttgtttg tgctaaatta aatgcatcaa ttacataatg ataagctgat 480 ggtgaaatac caactacacc atctgataaa ttaccaacag tattaactcc taatttatat 540 ttatcttttg gatcaatttc gctaccaata acaatctggt cagatttttt agataatgat 600 tctcccttaa ttgcattttc taataatttt atcgttgctg tgtctaaacg ttttgtaatt 660 gaaaaacgaa taacaccgtt tttatttccg cttagatgtg tgttaataaa tttatctgtt 720 tttttattga ttgcttgatc gttttcaatt tctacgtcaa caccaataac tcctacattg 780 tgtgaagttg ttgcaattgc ttcagtaaca gctattccaa cttgaggaat agctactggt 840 aaaattaaat cagcaccttt agtaattaat tcctgaataa tttttttagc attagcacta 900 tcagattgga aacctccagc actactttct gaagcataaa cttgttcaac attaatccat 960 ttttttgttt cttgtgttcc ttcttgttta atgtttttat cttttaattt ttcattagct 1020 catttaacac ctaaatcaaa acctgctaag taattggttg tatttttagc atttatacct 1080 acatacccac ctcaagttaa tttattatct gcaccaaaaa ctgcttgatt tgagtttaac 1140 atataagctg cagcaatacc tcctaaaaaa gcggcttcat caactttaaa ataaacatca 1200 gcaacacgat ctgctccctt ataaaactca gctttattgt cattattata aactccatct 1260 aaaattaaag cgattaaatt aggatcaaat ttatcattta ctaaagcatt ttgtaatctt 1320 tcaggatgtt gataaccagg cattaataaa gctcgtttac catcactagc catactttta 1380 tattttgttt gaaaaccttc atcatcatca cttgttggtg aagtccaata aaattgacta 1440 tagtttaatg tagatttttg tgtacatgat gttgctacag taataattgt acctaaagca 1500 aaaacgctac caattgctaa aaatagaact tttttattta actttttcat 1550 4 1413 DNA Ureaplasma urealyticum 4 ttaaaaatct gatttagccg tgttgattct tgttttaaat tgggttttgg gatcattaat 60 tccttgtgta ctactaatta ttcaagatcc tgtattttta atcataatta atttattcat 120 tgagtttaat aaatgggatg ggcccatata aattgcaaaa tttttatcaa caaattccgc 180 tttttcacta tcattaggag ccttattaat tttttctaat ttatcataat taatcaactc 240 ttttaaataa ttaccaacac cttgggtttt taaattaata ttattaaaac tttcataatc 300 aactattgca tcaggtttta aaccgaatga aattaaatga tcaatactat ctgctcatgt 360 cccaacaatt ttataaccat aagttagctt aaaattttta tttatataat gaggtttaat 420 tattaaatta cgctctttaa tagttggttt gtgatcaaat aaatttatta attcttcttt 480 attaaatggg agataacttc attgtttttt tattgttttt ttatttgtga aaatttttaa 540 taattcttta ataattagtg attgcccaac cattgtaaaa gaacctcatc aaaacaatga 600 acgatcaata aaaataattt ttgaacgaga attgcgtaag aatttatgag cataaaaatt 660 tttgtttgat aaaatttctt taaataaatc ttcacgtttt tgaccatctg ttttgtattt 720 attattagta aataaattag aatcatacat ataaaaaaca taatcagctg ttttataaaa 780 tgaagatgtt tgttttaaga ctgattcgag cgggtttgtt cttaatgcat tataaccaat 840 tgattgataa cgatcaataa tatcactaat atcattatta attggttttg gaaaattcaa 900 tcccaatcct ggaacttctg tataaggatt agaatagatt agtggaaaat ctgaaggtgt 960 tagaatagaa aatttattat aattttcttt attattaact aattcattac gattttctat 1020 aactaaaaca gttgctttat gattgcgcat tttttggatg ctatcgagca ttgctacatt 1080 attaatatca ttttttaata aacgtgcgat ctttagactt cattcagtaa atgaatgtac 1140 attttgcatt ggttttggta gacgtttttt taattcatta aaatttaaaa cattatctaa 1200 ttggcgagca aattctaaat gaattttata aggatcacga aaaaaattat tcaatctcca 1260 atttttattt ttgaataatc aattagtatc atacggtttt tgttgttgaa gatttttaca 1320 tgaacttaat gttgtaaaaa taatacttaa tccaagcatt gaaattacat taattaatct 1380 aaatttaaaa ctaattttca ttattaaaac cat 1413 5 972 DNA Ureaplasma urealyticum 5 ttatttattt tgattaaatc ctttaatcgt ttttaaatat tctaaaactg cttcttgact 60 tccattgcct tttttaatca aaatcttaaa aaccaccgct gttttgttat taacatcagg 120 ttcaacactt tgaatttcat aaataaaacc tgtttggaat ggtaatttaa ataatgtttt 180 ataattttca ataacttctt ttattgtttt ttgttttgtt ttttcatcaa ttaattgtgg 240 ttcaagttga tttttatctt gtttaatcgc ttctaaatta gctaaataaa tctttttatc 300 agcttcagaa ataaaaccat taagtgtttt gttataagta atgcttgcta aattttctcc 360 attaccttta ctgattttaa tttcgatatc aatagaatta gcagttttac ttttagtaat 420 ttttagaatt tcatatttta aatcattatt actattgtta atatttaaat aactattttg 480 tcattttaat gcttcatcta ctgttgtttt actaatgtta atacttgaat taactatggg 540 cattaaataa agagtattat ggtttttttc atcttctaaa tattttttat tttctaaaaa 600 taaacgatat tgtttagcat tcttaaaacc ttttaagatt tttttgtaag tgtgcgtttg 660 acctttaaaa tgataacgaa ttattagatc aattacatct tcatctaact cattcaatcg 720 tgcatcatat aattcatatt taatatcttt atttggtgcc aaaaattgaa tattagtttt 780 aataatctta ataaattctg aagctaaaat ctttgaaaaa tcatgttgat cataaccttt 840 aatggttgga taaatttcat tctcttgttt tgattttatt gatgagctgc acgcaacacc 900 acttgttgtt atcaaaccta atagtccaac aattaaacta ctaatgaaaa ctgttttaat 960 ttttttattc ac 972 6 747 DNA Ureaplasma urealyticum 6 ttagtctaaa ttaattttaa tttttttaaa taattgagcc tgttgttcat ttttaccttt 60 actaatcatt atttccacaa ctaattcacg ttgtctttca tctaatggtt caaaatagtt 120 aatgtctatt attttaatat taatatcttt aaattttgag tctactttta attgaggaat 180 taaatcctca ccaaaattaa aagctttttc acctaatgtt ttaatttcaa ccaaacttct 240 tttttgatat tctggtttta ttctaagatt aaaaaaacct attttttgtt tttgatcata 300 atcccaagca cttttaataa tatttaaatt ttgttgaagg attgttttat cttctttttg 360 tttaggagtt aaaaatggtt gaaaataaaa atcataatta attgattctt tatatttttg 420 aattttagca ttaatcgtaa ctttaagaat ttgttctgaa tcctttttaa tatcaacaat 480 tttatactgg acattctttg gatttcttga taaatcataa actagtaggt tatttgatcc 540 gtctttattg atttttactt tttttaaaac atcatcaata gtattgttat cattagcaaa 600 ttcttttgct aatgaaactg ttggacgata agttaaaata acatcctggt taattttaaa 660 ttgcgaacaa gcgctaacga taaggggaat tgccaaaatt ggcaatccca aaaaagacat 720 gattattttt tttaatttta ttttcat 747 7 2244 DNA Ureaplasma urealyticum 7 atgaatctaa aaacaaaatt ttttttaaaa gttataagtg ttattgctcc aattgttata 60 attccaacta ttttagctaa ttgtgcacat ataaattcta atgaacttga taatgctaaa 120 acaaacttga aaggaagtgt tgaagttgtt aatattaatc cttataaaac aaaacaaatg 180 ttagcatcaa atatcaacaa agaacaaatt aattcttatt ttatttttat ttttaattta 240 attaaaacaa atcaaaaaat tgaagaaaaa attttagata aaaatgatta tgaaattctt 300 aattgagctg ctaatgataa tgatggaacg ttaggtatta acatttacat taaaaccact 360 aaacaaagtt atttaattaa tactaagcct gtttttttaa cagataaaca aaacaattat 420 ctacaagaat taaaatataa aacacctgct gtttatagta ttgatgaaat cttaaaattc 480 tcaaacaacc cttataattt aattcacaat aatccatact atagagaaca attattgcgt 540 gcaaaaattt attttaatca aaatgaagct aatgttgatg attctaaact ttatatgaac 600 aaaatcggtt attctgaatt tggtagtgat gtccaaaaaa gattagaaaa cgcctttaaa 660 attcgttatg atgagcaaaa tatttatcaa attaattctc cgcaaatttt agctaaagaa 720 acaaaaacgc ttacatctta tattgataaa aaaacaaaca acaattatag tattaatata 780 gaattaatca aaaaattaat ccaaattaat ccttttggta aactccccaa aaatttcgct 840 caactaatta atttaattaa aaaagaagaa tatcctaaat tcttgacaat tactaaaaac 900 gaatctgttg acaatattgt tgttaaagat atttattatc ggattattga tcgttatgca 960 aaattagaat ttattttaga aatttataac aaaaaaacaa aacaaaccgt atatttaagt 1020 gctaatttta atcaaaagaa ttcaggatta ttaaaaaatg aagattattt tcaatatatt 1080 tttgatcgta ccatctcact tgatttacta acaacaaaag atggaaaaaa tgttgaatta 1140 aattctggaa ctggttgaat tgttgatcgt attattgacg atagcttacc taaaaataaa 1200 attaaattac ttattgcaac taataatcat gttatgggct gatcgaattt agcaatctca 1260 aaagataaca gaatgaaatc acgctggttt aataaacaag aatatataaa ttatttagaa 1320 aataacgctg gtttcatatc ctcaaacatt tatgaagata aagaccgtta tcaatattta 1380 ctatggggga ctgcgcctct aaaatctcca gtaagtaata aatataattc attaagtggt 1440 attagttttt caaatttagc aaaggtttat aatattacaa atcaaaattt cattaatcga 1500 gcatgatata taccacaatt aagtgctaat ggtataaaaa tcaatgaaaa tttaagaaca 1560 tgatatcaaa ttaatcaaga agatattaaa tcaattaaaa atggaacttt agactttgtt 1620 ttggtcccaa tggtttttga tattgaagat attaaagaaa aattaccaaa ttattataaa 1680 gtattaaata caaaagatga agcaaattga tatattggat taggcaattc aaaaaaatac 1740 ttgccacaat tacaactatt tagtggagga tatcctggtg atgttaatcc taatagttca 1800 gcgattgttt catggcgcgg ttctaaatct tatggttcac taattcaagc atttgatcgt 1860 gaaattaaaa atgaatcaat tttagattat tatggtccaa agcaaattaa taatattgat 1920 ggttatcaaa aggttggcga aggttattta aataaattat ttaatgttgg aacacgagtt 1980 attacctctg atgaaatagg tgatttgggt tctggttcat ctggttcaat gattattgat 2040 tctaacttta atttagtagg tattcatttt gcttctttaa attcgcgtgc ttatggtgcg 2100 ccaaatgatt caatgattgg taatttattt gttgctcaat cccaagactt aagtggtgat 2160 attgatgtaa gagctgcggt gataaaaaaa ctaaaagctg aaaatattta cacttataaa 2220 ctaaacccta aagttagttc ttaa 2244 8 765 DNA Ureaplasma urealyticum 8 atggccattg ttgctaaaat aaacggaaat gcatcagaat gatatcacgc accaatcgct 60 ttagctttct tcttacggtt ttcattaatt aataaaattt ttgcaattat actatcttgt 120 attttttgcg taagcattta tcgttttcgt aaaaaattag tacaatatga aaattttaat 180 gaaataaaat caattaaaaa taatgcgatt cttactgtaa tttttagtgt tgttgcaata 240 ctttcattaa cactatttat taatttaatg attgttttta ttaatcaaaa ttactattac 300 attaaacgta ttcataattt acttatacca ataagaattg atgaaattaa aattttagaa 360 tatagttaca tttatttatt acgttgtgga ttttatattt tattaacagt atttatagca 420 aaatttattc atgataaaag aagtatgata aaggttttat cattatattt attcgttaat 480 tttatattaa tgattattgg aacttcattt acttttttag aacatacaaa cttttataat 540 ggtatgttaa cttattgaac aacttttagt tgtggattat tatatccaga aattattaat 600 gataattttc agtgaataag tagttttaat tacaatctaa aaaatactat ttatgaaaat 660 aactttattg cttatttacc ttatttttgc tcatttatcg ttttaataat cttaattaaa 720 aaagttagtt gaaaatcaat tactattagt tcaaatagtt attaa 765 9 528 DNA Ureaplasma urealyticum 9 ttagttatct tgatttttat tatattttct taaaggacaa taatcatatt ttttagtatc 60 tttatcatta taagattgac tttcatatcc taaatgatga tgatcaataa gtaaaggaaa 120 taaaatatta tcgatttttg agcatattac tctaactgat cttccaaggc ctagttgata 180 aagttctaat tcttcattat catttttcaa taaattagga tggagttttt taattaattt 240 aatatattta ctaaatacat tattttgttt aataggatgg caatgatcgt taattccttt 300 attttttcaa tttttataaa catagggaaa caatgtatta agaatataaa taatattttt 360 taaaaattgg ttttcatcct tagtataagt cgttaaacta tttactcgtt cctctttaac 420 tcaattttca taacgcaaag aaataacaat gtcatcatta tcttttgaaa cattgttatt 480 tttaacttta ttgcgaggag ttttattgtt atttattttc ttagacat 528 10 1068 DNA Ureaplasma urealyticum 10 ttactttttt ctattattaa attttgatat tatattgttt agttcatttt tattttcatc 60 taattcgatt attttttctt ttaaaaataa aagtgcaaac ttggaaaact tatgtgtttt 120 attggttttt gatgttgtaa tttctaaatg atattttttc gattccttca ttttaaaata 180 tcaaataagt gcatataatt tttgaggtgt tatattaagt ttttcggcta attgtttttg 240 aatataggga taagtttcat ctaaattttc taatggaact ggaacttctt ctgccaaatt 300 tatatttcca gtaactttga ttactggtat tccttcattt tcactaaaac taccttcttt 360 tataaatttt gcttttttta gtaattttgc tataagattt ttttctaaaa caacatcaac 420 tccataagga gtggacaatt ttccgttatt ataatcaact attcctaaat tagtagcacc 480 attatttcta ataaattcaa aaaccttaaa taagctatct cgttcttgct tcattctaca 540 attaataatt tgttccattt ctgcatattt tattttttca gttctcgctc tataacgata 600 aaatatatca ccattaacaa ttttttctga actattattc ttttgtgcta tcactggttt 660 tatatttgat tcttcggtat aaattcaccc aataattttt tgaacaatga taacatcccc 720 attagaatta atttcttttt cttttaaaat aaatgagcct aattctcaat ttatagaagg 780 ggaaaataga ttattaatag aatctgtcaa atcttcttgt tgaatatttt caaaattact 840 attttgtaac ccaattatgg aacgaggtga atctttaata ccaaaaataa tatatccacc 900 actgttatta gaaaatgctg ccatagtttt agcatatatt gcaatgttgc ctttattaaa 960 tgattgttta aattcaactt gagtattttc cctactacgc aaatttccat tttccatacg 1020 agcagataat atactcttta ctctttcttc atgttttgat ataagcat 1068 11 759 DNA Ureaplasma urealyticum 11 ttatgttttt attttttgat agcctataat aagagcgcac attcttttga taaaatcttc 60 ataattattt aatattatag aattaccaaa taaatcatcg attttgtttg aataacttag 120 taagtcttca tcattcataa tttctttata acatcttatg taatcttttt tatttttaat 180 ttcctcacta atttctttca aactaagtaa aatgaagagc gttttatctg gtgtatgaaa 240 ataaacttta gggtcatcat ctgataattt taaatatttt tccaaattgt ggtttgaaat 300 attatcatat ttttgtaata caccatcact tttatagtat ggaactttat caaaaattat 360 aaaaatttga aaataaggaa ctgaattaga tcgtaaatta gctgtttcgc ctaacatatt 420 ctcaaaataa ttattactat tttgagaata attactcata acaaatttaa ttgctagtcc 480 agcaattgat tttccattat ttttaattgt tatatcaact tttttgttgt aatatctacc 540 atcaatacat tcttctttat catctctata accttgggat ttaatattgt attctttgcc 600 taacaattct tctaaatctt ttgctatact cccatgtaat gtttttaatt ttttagtact 660 tctagacgtt ccaacactca aataattatc aaaagattcc tttataatat ctaaatctaa 720 aaattttttg ttactcaaca ttttattaaa tttcctcat 759 12 267 DNA Ureaplasma urealyticum 12 ttatcaattt ctataccatg tataaatgtt tctaattgtt ttttttaact caattaaatc 60 attattattt ataagataat ctttgcaata tctatcaact atataagtta aaaattgccc 120 atctccacaa ctattatcaa ttacatgttt tttatttata tttccattaa tataatgccc 180 tttatcaagt attatattta ctaaataatc aggtgtataa acttttccat agcgtttaac 240 cttagtcaat ctcaataatt ctttcat 267 13 417 DNA Ureaplasma urealyticum 13 atgtctccaa ttagtattga attaataatt caaataagta ttggattaag tgctagccta 60 attttattgt ttgctttctt accacaaaca cttttaacta ttaaaactaa aaatactgct 120 gcattaacaa ttagtatgtt tattatttgt tttattgcac gtttatgttt tagtttaagt 180 gctattctaa caattatcgt ctatattcat aatcagaatt atggtttatc tttatatgcg 240 cttacacttc ctgttttaat atgtcatggt attaatatgt tattaaattt aattattgct 300 tttataaaaa tcaataatgt ttataaagcc aaaatccata aaatgaatga gaatgaatat 360 attatttttg cttatgctca aaaattaaag gaaaaagtat cgataaaaaa taaataa 417 14 2349 DNA Ureaplasma urealyticum 14 atgaaattta ttaaacgtaa aacaaaatta ttaacgatta caattggtgc agttgctgtt 60 agttcaatct tattaggagg aattttttat ggtacaagtc aaaaaagtcc ctcaagtttt 120 ggtattgctt ctattgatca aaaagaaaat tttattaata aagacaattt agattaccaa 180 aaagcaagac catcaattaa agatagtaac ttaaaagaaa ttcccaaacc taaacctcaa 240 ccaaaaccta agcctcaacc aactccattt ccagatccca tcccaacacc tccaaaaaaa 300 gaagagctaa aaaaaccaga tattaaacca gaagaaccta aaaaacctga aattaaacca 360 gaaccaaaac ctgagcctat tcctcaacca gcccctccta ttgaaacaaa accaaaagaa 420 gaattattac cacccaaccc tccgcctcca aaagaagaac caaaaccaga accaaatccg 480 caaccacagc cacaacaggt tccaaacaat agtaattcac gaattataga aattaatggt 540 gtaagagtgg aagctgaagt tgaagtccct ccccctcgtg atattgctga atatgataaa 600 caaaataatc tggttaaccc taatccatac attaatgata gtgttggtaa aattaaaaac 660 gtaaaggtta ccgatgaatt gcgaaaagca acaggtaaat tggtccaagg aaatttagga 720 cgttgagatt acaaacattt aattaatgat ttattaactc ttaaaccaga ggaaatagaa 780 aaatatgtaa aaaacgataa aagcggttat tatgcaaaag tttgatatcg tttttcaaga 840 ttatttgaat ctgaaaatgt tgttaatttt ttaactgaac aaggtaaaaa agaatatcct 900 gaaatgaagt ctaaatttgt ttcaaaagac cataaatatg catggcttta tcaacattta 960 gacttaacaa agtttacaca attatcaaat gaatcagaat cttatttaaa agaaggctat 1020 acacctgatc ctgataatgc atatgttgat gaaaatggaa aaattagttc tcacgcatat 1080 tcacctgcca aaggttataa ttcggtaaca agtcgaatgg aaaatgataa ttgaaatcgg 1140 cgtgttttcg gttataaaag ttggtatgga cgtactcctg gaaatttagt tgaaggtaat 1200 tatcctggtt gaaagaaaac aaatgtaacc caagaattcc atcaatatgg cgttagcgat 1260 ggtgatggaa ttacagttaa taaattaact cgtgaaaaaa ctgaagatgg tcgtttaaat 1320 gaaggatatg ttattgatat tgatgctgat aatccacaag gttatgaaaa aacaaaaaaa 1380 ttaattcaaa ctttaaaaga aaaaaatatc aatatcacag ggtatagaat tcataatatg 1440 gggaaatcag attcaagtca aaaatttgtt gatattctaa aaacattacc aaatcaattg 1500 cctttattag aattgttttt ctccgctggt tcgcataata cctcttcatt aatcgcactg 1560 aaggataaaa aaattaaaga attaggtttg ttcacactag gaaattcatt attagatgaa 1620 tgatcaatta atcctaatgc cttacgaaat gttgaatgaa ttaattcaaa cgattataat 1680 gtttcattta attataaaca aggtgcagat atcgctactc gtattacttt tgatacttta 1740 gcttttgatg aaagtgatta taatgacaat gcatctgaca ttaaatcaaa attaaaacaa 1800 attaatgatg gtttacgaat ggtttattga acaagaaata atgaaccaat ttttcagggt 1860 agttttggac ctggtttaga tcctgaccac aaagaatcag gcaacagtta tccacaagga 1920 ttagatttta gtcgtgtccc tcaaattcgc tcattacggg gtttaatatt taaagatgaa 1980 caaaaaacat caaataataa agatcgtaaa ttacgaagaa ttaattttta caataacagc 2040 acaacttata aaatgtctat tgaggactta aatgaagccg gatttaacga acatattgta 2100 agtggtgaac ctggtgaaaa aagtaaaatt acttttagca atggttctgg tacaactaaa 2160 atccaaattg atggtgatca agaattgtca gcaaatggaa ttagtaactt atcagcaatg 2220 tttaattttg ctgaaagttt acaacggaca attgttgtaa ataataccaa ctcaccactt 2280 gcaaatcaac taagaaatgc gggatatagt gttgaatcaa caactaacgc tggactaata 2340 gatatttaa 2349 15 2376 DNA Ureaplasma urealyticum 15 atgaaattta ttaaacgtaa aacaaaatta ttaacgatta caattggtgc agttgctgtg 60 agttcaattt tattaggagg aattttttat ggtacaagtc aaaaaagtcc ttcaagtttt 120 ggtattgctt ctattgatca aaaagaaaat tttattaata aagacaattt agattaccaa 180 aaagcaagac catcaattaa agataataac ttaaaagaaa ttcccaaacc aaaacctcag 240 ccaaaaccag aaccacaacc aacaccattt ccagatccca tcccaacacc tccaaaaaaa 300 gaagagttaa aaaaaccaga gattaaacca gaagagccta aaaagcctga aattaaacca 360 gaaccaattc ctaaaccaaa acctcagcct attcctcaac caacacctcc tgttgaaact 420 aaaccaaaag aagaattatt accaccaagc ccaccacctc caaaagaaga accaaaacca 480 gaaccagatc cacaaccaca accacaacaa attcctaacc aaagtactgt tagaaaaatt 540 gaattgaatg gtgttttagt ggacgctgaa gttgaagttc caccccctcg tcaaactttt 600 aaatatgatc aggataatgg attatcaaat cttaatccct atacaaatat aagtgttggg 660 aaaattaaaa aagtttttgt aacagatgag ttgcggcaca aatcagcaga tttagtgcgc 720 gggaatttaa agcgtggcga ttatcaaagt ttagttaaag atttattaga tccaaatata 780 aaaccagagg aaattgatag ttatatcgca atggttgata aaagtggata tcacgctaaa 840 ttatgaagta aatttaaaaa actatttgat acagacaatg ttgttaattt tctgaatgaa 900 caaggtaaaa aagaatatcc taatatgaaa acaaaatttg tttctgatgc gcacaagtat 960 gcttgattat atgctcattt agatttttca aaattcacta aactttcagc caattctgaa 1020 aagtatttac aagaaggttt aacgcctgat ccagataatt catatgttaa tgaaaacggc 1080 gaattagact catatgctta ttcacctgct aaagaatata atacagtaac aagccgttta 1140 gcaaatgata atgctaaccg aagggtgttt gggtataacg aatgatacaa tcgtagtcca 1200 aatggtttag ctaatggtga ttatcctggt tgaaataaat cagatgcaac agctgagttc 1260 aaacagtatg gcattaaaga tggtgatggt attaaagttt ataaactaga gcgccaaaaa 1320 ccacaagaag gtaaattaaa tactggatat attgttgata ttgatgctga taatcctgat 1380 ggataccaaa aaacaaaaga attaattcaa aaattaaata atcaaaacaa aaaaattaca 1440 ggatatcgaa ttcgtaacat ggggaaatca gattcaggac aaaagttctc tgatattcta 1500 aaagccttac caaatgaatt gccattgctt gaattgttct tttctgctgg ttcacataat 1560 acgtcagcac tttctgctct tgaaactaaa catattaaag aacttgggtt gtatacatta 1620 ggtaattcat tattagatga atgatcaatt aatccaaatg cgcttcgaaa agtagaatga 1680 attaattcta atgattataa tgtttcgtca gaatataaac aaggatcaga tattgctaca 1740 cgaattactt ttgatactct ttcttttgat aaaaatgatt tcaatgataa tgcaaatgat 1800 cttcgaacaa aattaaaacg tattaatgat ggattacgaa tggtttattg aacaagaaat 1860 aatgaaccat tctttcaagg tggatttggt ccaggattag atcctgatca taaagaggtg 1920 ggaaatagtt atccccaagg tttagacttt agtcgtgtcc ctcaaattcg ctcattacgg 1980 ggtttaatat ttaaagacga acaaaaagct tcaaacaatc gtgaacgtaa attaagaaga 2040 gttaatttct ttaatgataa agaaaattat gaaatgtcaa ttaatgattt aaatgaagct 2100 ggttttagtg aacatattgt gactaatgaa ccaatgcctc ctaaaagtaa aattactttt 2160 agtaatggta atgctacaaa acgtatttac attaaaggca atggtagtct aactgcaagt 2220 ggtattcaaa atttagctac attatttaat ctagcagaaa gtttagattc taaatctgtt 2280 gttgttgatt ctaataattc agaattaaag tcacaattag aaggtttagg atataaagta 2340 agtgatgctt ctgacgctaa ctatattgat atttaa 2376 16 1505 DNA Ureaplasma urealyticum 16 atgatgaata caaaaacatt tacttccgtt aatagagtaa tttatgatga taactattcg 60 ctaaagcaac aacaaaaaag tagctttatc aatcaatttt taaaaggatt gttatctgct 120 attactttat tattctttat tttactttta atctttgctg aaaatacgtt gtttggttta 180 ggttttggtg atgagaataa atcaatgatg atttcaaaat cgctaaatgc tttttttgat 240 ttacacagcc ctaaatattt acaacttaac tttttaattg tatttcgctt ttttatttta 300 agttttacac tgttttatac cttaatcaaa aatttcacaa atctttattg gcatcgagca 360 accattaaaa aatacttacc atgattcgtt ttatatttag tgattgcaac aattagtttc 420 ttactatttt ttactttttt tagtgtttga ccaaaagaag tttttaattt agtattttta 480 ctattagtgt tatttttatt aaatttaagt tatgaaatat ttaattattt tatttctaaa 540 aaaactaacc ctttattata cgataattat aaaaatttaa ttattgccat ggtttttcaa 600 gcgttattac tattatttgt aataattacc ccccttgtat gaattaatac aggtaaaagt 660 cctaactttt tatttgttga taatcgtttc tacacacgca tagttgatat cttcactgtt 720 caatcaggta aaaattttat tattttaatt gctttcttct tctttttaat tacatttatt 780 gttttagcaa atactaattt tttcgcttta gtaattaata aacgttacga tcgtaattat 840 gttaagaata atttatgatt tattttactt ttatttagtg ctatatttat ttgattatta 900 agagtttttg catataagca cgaaaatgaa aatctaccgg ttggtaacaa ccatttatta 960 tgagtttata ttttacaaag tttttttgca ataatcatat taatactata tatggtattc 1020 actttaaaaa aacgcttaag cgtaaagagt agtttaaata ctttattaaa tttagtagtc 1080 actcaaacaa ttctaagttt aagcttgttt ttagtaacat tatttaattc taagagtgtg 1140 gtttctttaa ttaatgtttt tattacaatt actgtacaaa tgagtgtgtt tggaatctac 1200 atatttcaaa ataaaaacat ttcaactaaa ttattggtgc tattaaaggt tattatgatt 1260 ttaattattt taaccgcagc aattgtaggt tttgattatt tattaacatc tgatcatcat 1320 aataactatt tattctcaaa cattcaaccg aaaatgaatt tagtacaaat catgttgtta 1380 ttaaatttta gtttgaattt tactttaatt agttatttaa caattaaatt tgcaatggta 1440 atttttaaaa tcaataagct aaataaggag ttaaacaatg aaaaaaaata aatctaatct 1500 gacac 1505 17 516 DNA Ureaplasma urealyticum 17 atgaaaaaaa ataaatctaa tctgacacct acaacaaatt attttgatgt atttaatact 60 tataaagaga aaaaagcaag tgttgattta attacatatg aagaattaat ggcatcagtt 120 ttatttgata ataaattagg ttttgaatca gaggtttatt tagattttgt taaaaaattt 180 acattagctt ttgaaaaaaa actagatatt tgatttgaaa attttattat taatttcaat 240 ttaaatttaa aattttcaac aactattatg attccaatat tagtaactaa agctaattct 300 acaactgatg caattaattt tagaaatgat caaaatcctg tttataataa ttttttaatt 360 tcatataacc aaaaaattaa aaaattatta cttcaaaatc atcctgttca aattcttcct 420 catttgattt tatttaaatc aaatcttaat ggtagtttag tgctcgtatt tagtgaaaaa 480 attatcgctt caattgaaca aaaatcagga aattaa 516 18 915 DNA Ureaplasma urealyticum 18 atgcaattaa aagatttaat taataaaaaa aagaatttaa ataatattaa tttaaaagtg 60 agtaacgaac gtaatatttt tttaattaat attatgaaac taaatcagcg attaactttt 120 tttagtaaaa atgcttttga aataaaagaa tcaattctaa gtttaaagcg tatttataat 180 attaaacatg atatgttaag acatgaggaa cgaaagattt ttaagttttt aaataaaatt 240 aatgatcgtg ttttatggat ttatttaact gaagagcaaa aatatagtac tgattcatat 300 tcgcgttatg aacaaaaaat cttaaaaacg attaaatcaa atcgtgatga ttttattttg 360 atcggtcaag gagcaattga atttggtaag aatcataatt taaatgttct gcaaacattt 420 aatgactcaa atattaaaaa tttaactaca caattaacta aaatgattat gattttatat 480 acttttgata attataaaaa agttaatttt gttattaatt ctaataaaaa ctatgatgga 540 cactttacta tattaccaat gaatgaattt agttttgata aatttattaa tttacaaaaa 600 tgcgattcta atattattga ttttcaaaaa gtaaaaattt atccaaattt aaatgaattt 660 attaatgtcc aaattaatgt tttcttagtt aatattatta atactttaat tactgaatca 720 tctttttata aaacaaaaaa tggactagta gctactaata atatcctaaa agaactagat 780 gataaccttt caaaaattca acgtaaaatt acacgtgtaa agacagagtt gcaaattgaa 840 gaaataaatt tattagcaag acaaaatatg aatgaagatg ataatgataa cgatggtggt 900 gtttatgaat cataa 915 19 513 DNA Ureaplasma urealyticum 19 atgaagatga taatgataac gatggtggtg tttatgaatc ataattataa tattcaaatt 60 acattacttg aaaacaaaaa gtttaatatt gataatggtt tattatatgt aaatgttaat 120 gaagaaaata catgacaaaa aattgaaaac aacaccgttt tagcctatga aataatctta 180 ttaaaaatag ttgatgatga ttataaaaaa actttttatt tatttctaaa aaacacacat 240 atttctgttt taaataacat cgttaaaatt caagcattaa atgatttaca tttctttatt 300 aaagatggat taaacaaaaa aaataatcat aaaaaagagt tggtagataa atataaaaat 360 attactaata atattttaga acttgaagct aaacaacaat taggattaac tctaagtgaa 420 tttttagatc ttgataatct aaaacaagaa caatatataa ctaatatgca aattagatta 480 aatttagtgg agtataaaaa agatgagaaa taa 513 20 2166 DNA Ureaplasma urealyticum 20 atgagaaata aattgaaaat aaaattaaaa tttttagctt cactagcaac aataccaatt 60 gtagcttcac cattaatttt ttctgttgca gctaatgagg atggtaaaca agaaaacaat 120 aatggtaata atcatgatcc taatcaacaa aaaaaaccaa aaattcctaa aaacgatcct 180 aattttaata cttttaaaac tgatgctgat aaaactgtta aagatagttt agaaaaagga 240 attaatgctg ctattgttta tgtaaaatca cgtcaagaag aaattttaga aaataaagaa 300 attgagttta agaaaaaaat tcaacaacta atttatttaa aaaatctgca gtcatatctt 360 gagaaaaata aagaaaacat cttaaaaaat cctaatgatt atggttttta tttaaatact 420 cctcaaattt taggaactct taaaaattat gatattaaag atattgagtt taatggagaa 480 acatataagc aaatcaaagt tggcaaaact gatcctttaa attatcaaaa agccgttgct 540 ccaaaaggaa aaattagtga tgtacaaagt gatcaaatta atgatgttga agaaacaaaa 600 tacaaagata cgttaaaaaa atatgaatct gaatttttaa aagaaattaa taaattaatt 660 tatgatgaaa atgatgttcc acaaattaac aaagatgttg agttaacacg tgatgaaaaa 720 ggacaattta atacaacttt acctaaaggt tataatgatt gaaacgctta ttttatttct 780 aaaataaaag atcgtgttac agcatttgat ttaaaacaaa atcaacaaac aaacgaagat 840 aaacaagaag aacagccaaa tgagcaaaaa gatcccgata caccaccacc attaccacca 900 ccattagtag aaggcgatca taatgaaata gatcttcccc caacacaagc taatgctatt 960 atttcttctt taccactatt attaccttat attagtccta tatattcaaa tgaatcatta 1020 agtggattaa aatcaaaatt tgatagttta aaaccagagc ttaaacaaac attattttat 1080 tttaataacc caattaacac acgttatctt tatagtgtat tagattttgg cgttaatggt 1140 agtagtatga ttaatattaa agttaaaatt attgatcaag ttaatcctaa actacaacgt 1200 acatatatta ttaataaata tgatccaatt ttagatatta attttaatag tctaaaatta 1260 aatgaagtta atgctattaa acaaattttt gttaacttgt ataaacattt aggactagat 1320 gagaaaattg attataagaa attacgtaac ttttatatta gaaatgcttt atttacaatg 1380 attgaagctg ctcaaaaact tattttgcga ttcaatcaaa ttgataaaga taataaaatt 1440 attggtcaaa aaacttttgc aacattacaa aatgaatatt tagaaaaata caaacaaaaa 1500 cttgtaaaca acaccgatga taaggaaaga ttattaaatg agtttaataa tttaacaaaa 1560 gaaaatttct ttcgttattt aaataacact ttaatcaata atgattatta ttgatatcaa 1620 ctagttggtg cttataaaca agttagctta cagtttagtg aagttcttcg attaaataaa 1680 gataaaatta aagctaatat tgcaagtatt aaaggtgatg aaaacaccat tgcaaattta 1740 tataaattaa ataaccaatt aatttatcaa ttatcggcga ttgttgcaca acgtagtttt 1800 aattctcaac aatgatatca gtcatattta aatgttttac aaccgattaa agaaaatttt 1860 gatttaatgt ctatattaac aaatcaaacc gatattaaaa caaataagga caaagctaag 1920 gattttaaaa atgcatatga tagtgcttta aaatctcttg aaagacaaaa acaagtaaat 1980 aaacaaattc gtcgtaagat tggaattgcg tttatagtaa ttagcttact ggttttaata 2040 attaatttaa ttatttatgg attgattaaa aaactaaaaa ataaaaaagt tattctaatt 2100 attaatagtg tgataatggt gttgacaatc attgttttaa taatgggaat tattctaata 2160 atttag 2166 21 225 DNA Ureaplasma urealyticum 21 atggcattaa caattgtttt aatcttgttt agtgttctag ctttaataat aggtttatta 60 ttatcaagaa cttcaccatc tggtggattg tcaagtttaa atggacaaga tctagaaatt 120 tttaaaaaaa caaaagaccg tggttgaatt aaaggtttac aagtctttat gtttttatta 180 acaattgtta tgattttaat aataattttt tatagagtga gctag 225 22 477 DNA Ureaplasma urealyticum 22 ttattttttt aattctatta ataaatgatt aagtaaatct gtaaaattag taaaatattg 60 gcaatgtgat aatatcatac catctaaaaa cttgtttaaa acttcattgc ggtgtttgtg 120 aactcttcaa tcagtattta aaatataaat ttttaacgtt ggtttaacgt gtttttgaag 180 tgctacaaaa taacccattt cagccatggt gccatcatca gtgttatcaa tatctataat 240 tgcgatatca gtttgatcaa taaatttaat atctgattca taaaaaaaga tatttggttt 300 atgtgcatta gcacctaatt cgtcgttaac ttcgatcgga ttaaaaagat caagttcata 360 atttggtaat tcatctttaa atgtttttct aattaaacta gcttgttgtt ttcgatcatt 420 aatttcagct aaggtgaata aaggaccagc taaataaatt ttgatttttt tactcat 477 23 267 DNA Ureaplasma urealyticum 23 ttacaataat gaaatttcta ttttattaat ttcgtggttt aattctttgg tttttaattc 60 caatgatttt cttttttgat ttaaactaat aattcttgat aaatttatta ttaaataaaa 120 tagccctact atggttaaaa aaaagattaa aataacggct atgattattt tcatcataaa 180 ttcattttta attttatcta attcaaactc aagatcatta actttttgct tcaattctat 240 taatttagtt ttttgttcgt cactcat 267 24 615 DNA Ureaplasma urealyticum 24 ttaattaata attaatttat tagtctcttc ataatcaaaa tattctttgc taatgtgtgt 60 taaaattaat aattctactt ttaatgatga tgaagttaat ttatttaaaa taattggtgt 120 gttaaattta atattttcat cttctaaaat tgattttaat aaattaatat tctcataatt 180 aatttgtgtt tttacattaa aaaaatcatc aaaaccagaa agaattaatt gtttactaat 240 attaatgtta ttagtatcga attgttctaa atccatatta tttggtgtta tatagtatga 300 tactgcaatt atttttttat ttttaattaa actaaattta gtgattgaat taaacttatt 360 accatgatat tcaaaatcaa ttagaaattg ttcgtattta atattatcaa tggttttgta 420 taaattagca aaagccttgt tagtaaagtg atcaatactt gaataaacat aataaccact 480 tcctttgatt gttgttacaa tgcctaaaac ttttaatact tcataagcat tatgaatagt 540 gattcgtcca caattaaaat aacttgctag tttatactca ctaggaatca attcatttat 600 tttatattga tccat 615 25 1968 DNA Ureaplasma urealyticum 25 ttatttttgg ttaacaaatg tttttcaata tgaaccccaa tcattagctt cttttaacaa 60 ttgtttattt tgttggatta attgcggatc aattgtttta ttaataattt taatcacaga 120 atctaaaatc atattatatc caataggtga tttaattcca tcatttcata attcataatt 180 atcatcaaaa atacgcttcg ctggatcatc ataatctgat ttaattaatg acatgattaa 240 ttctttttgt ggtcttgata aattattact atgaaaatct tctaagtttt gataactaat 300 tttaattaaa tagtcgaact ctgaattaaa tttagcaaag ttactagcac ttaatgatcc 360 ctctcctaaa tttcatcatc aaccattatc atccatatta aatagagaac caacaatgtt 420 tttatcaatt tgtgtcccat cttgattatc accaccaaaa caatgaattt gtccatttcc 480 gtgtctatga cataataatt gtttgccgtt aacatcttct aataattcag tccattcgtc 540 cttttttaag attggtttag gtgctttaaa ccctaaatca taatataaaa aaccgtattt 600 agattgagtt tgtaaagttg aagaaccact attttgtgat gtagttaata agcctaaagt 660 tttggaatta gtattatcaa attgttttat attaggatta taatttttat caacaacgcc 720 aattgcttga aaatacaaac gcattttgtt taagcgatta attaaattat tagcaatttg 780 attagcatta aataacgctt tttttaatgg ttctaatttt gctaaattat ctttaaaatc 840 aatttttgct tcttctgagt atgcatattt tgttgttgca taagcaatat catataaata 900 aagcaatgaa tcgcgcattg ttcctaaata aacctgtgta cctccatctc atcgcatatt 960 ttgttcataa ataggatggt gttgtagaat tgatgtaaca taactatctt gttttgtagt 1020 tgataaaaaa ggatcataat ttaatttatt taatcctgat tccctaactt tttttgttaa 1080 cacaactgtt ttaaatgctt cataaatttt tgaatttaat gatttaggat cttttcattt 1140 tgtttcagta taaaaaatag gtatatcatt accttctaaa attctttttt taaaagctga 1200 attattaaaa ttaataccat caaatgtttc agcattaaaa tagtttttgt ttaatttatc 1260 agcaaaatag gaataattat aaagttcgtt taattcacct ttttctttat ccttatactc 1320 taaacctaac aatagacttt tacgtaataa tgagttagga tcgtttttaa aatttaaaat 1380 gtcattttta tttaaggtta aataaaaatc acgactcatt ttaaaatcaa caggaatagc 1440 agttttttga tttgatatcg ggccaccatg tgcaactaat gttttttttg cacgttcaaa 1500 atgactatta tcaatcaaat aacgatcata ataaacaagt ttgcctttat ttttatttca 1560 atactcttca cttacacctt cgccataagt attgccacta aagcttcatc atgtagttcc 1620 atattgttta atattttttt ctaaattaat taatttttct ttaaatttat tagcaaaatc 1680 gtctttttca taaaatcatt tttgataatt tggtttttgg ggatttaaat aatcataagg 1740 tgaatttttc tttcaataca tttgttgagg ataataatca ggtgtaattc ctaacgctaa 1800 taaattatca gcctgagaag tataagttgg cattatatcg tatttgattt gctcttgaac 1860 gtttgcagat gttttttttg tacatgaact aataattgtt gttgtaccaa ttacaataga 1920 aattgttgcc aacatactaa ttaaatattt ttttgttttc ttatgcat 1968 26 1788 DNA Ureaplasma urealyticum 26 atgaataaaa aaataaattt gaacagcagt ttagcttata ttggtttttt aacacgcctt 60 attattgtaa aaaaaacaac atatctttta ccgatcataa ctttattaat tacattaatt 120 ataggaattg ttgtcggctg tgttgttaag caaaaaacac aatttttgat aatttcatat 180 gtaatgatca tgtttaattt attaatgaca acaatttttg cttcactaaa agcattaaat 240 atttttaagg attttagtga agatggtatt gatattttag taatttctaa accaattagc 300 cgtaaaaaca ttgtttgatc aaaaattttt ttcttcgtcc taacaggtat tgtttgaagt 360 ctagttagtt ttttaggact attaattttt tatttaatta gctttaattt tgctaaaaat 420 gttaattatt attgaatctt aagttatata agtcctttta tttgttattt aatttttggg 480 ttaataacaa gccttttagc tttaaaatta aatgcaaaaa taagtatttt aattcctttt 540 gttagtttta ttcccttact tactattgga attattgcga acttagttag tcaagtccaa 600 tcacaagcct ttttaagatt attaaaacaa aaatcaacaa acaatattga ggctttttat 660 ttaaataata atttagatca atattattta attaacacag gtttttttaa tcataaattt 720 aatgaaaatc aaaatttaga aattatgaac gcttatttaa aaactagaag tttagcaact 780 ttttgacaag taagtagttg aattcttcct gtttatcaat tagctgatgt ttttaataaa 840 agtgattatg agccatttag tgattttatt aaaaatcaag tagatcagat tttatatgcc 900 aataatttag catcaaaaca atttaattat cagttagaaa aaaatagtaa ttcattaatc 960 aattttagta ttaataatga taaaagtttt ttaattccaa gtttgttaaa aaacgattct 1020 caaaatttaa ttaacaataa cttaaatcaa gaagtaattt atgcaattga caattgaaaa 1080 gatcaaacga tcgaatatca aaaaaacagt tatacacaat taagtagtga tgatattgtt 1140 ggttcgctta aatgaatgat tattaaagag gtattaaacg taagatcgtt taatacatat 1200 gctaataatt tatttaaaac acttgatcaa aaagcaaatc aaaaacaaat cttagattta 1260 atttcaaata gtgtacaaaa atttgatttc aataaatgaa acgatgagaa tgctgattta 1320 tttaaaaagg attttaataa attattaatt aaatcaaaaa ctgaacaaca aatatattta 1380 gcagttagtt taatttatta tctatatttc aatccacact atacgaattt actaaaaatt 1440 ttattagttg atcatcaaaa taatttacaa tataaaacac aattaaaaat aaatttaaat 1500 aataaaaatt atttaattgg cggttttaaa agctacttac ttcatcagat attgcctcaa 1560 gaaaatgacg atggcataga tgaattaaaa aaagataaaa agattcgtta cagatatagt 1620 ttagaacaag gcggaaatta tttattcgat tatgtccaac aaaattatag ttttaaaaga 1680 aagcaacaaa ttgtttataa agaagcttac tgcgtaattt gattaatatt aatttttagt 1740 ttattaattg gtacatatta tggctataaa agaaaggact atcgttaa 1788 27 3165 DNA Ureaplasma urealyticum 27 atgtttaaaa aaagaagttc aagtcgtaaa tgatttataa tctgtacttc attatcaata 60 agtagtattg ctgtagtttc attaagtgca tgtgctaaca caaataataa aatagtaaac 120 gcaggtttta tttataatgg atcaacaacc aacgacgcaa ttactggttt tgatgtaaac 180 gattacataa ttaaagcgcc agaaaatgat actaatttaa atcaacaaat tttgagaaat 240 aataattatg aacaaaaacc aattctttga aatgattatt taaaagaata tgatagtgtt 300 aaaaaacaac acgatcaaca aatcaagaat ttttatgaat atatttgaat taatgaagca 360 tcaaaatata aaaatttaaa taaagttatt gatattaatg acccctattt tataaattga 420 tttttaaaat taacgcctaa tacattaaaa aatgatcttt ataattttat taataatatt 480 cgtaaagaca acactaaacc atcacttgtt ttttcatcaa gtgaaccaca aattaaagtt 540 tgaaaagatt taggaaataa tcaaaaacaa gttttaaatc ccaatcaagc catttttgaa 600 ccactaacag aacaagatat taaaaataat attaatcttt tagaaaagaa taaggcgtta 660 agagttagca ttagtttttg gtatgcttta acaaatcaaa gtagtgctaa tattttaatc 720 aatgatccat tttataaaaa accttctggg attgcttcaa atactagtga aaaatatttt 780 attaggattg aagcatcacc gatcgcttta gattttagcc aaaccgatcg attagaacgc 840 gataaatata gtgcacaaac cacatcaatt aaaaacacat ataaaatgcg ttattatttt 900 aataatattc gtgttgaaaa acaagttaca aaggttaaaa acaatgctaa acgtggagac 960 caaaacgcag aagaaaattt tccaaaagaa ttttatttcg gtgctaatag taatgaaaaa 1020 tttagctttg gtacacactc atacacatta aataatgaaa tcacacaagc ttcatatgaa 1080 caagatattt ttagtttaga tcataaaatt aaaaacgaat taaaaaaatt aaatgaacaa 1140 caaattttaa aagatattga atatgcattt actagtggtt atgatgtagc aattgattcc 1200 attggtagta tttttaacat tttaaaaggt gttgctaatg atttaaattt aaaagaattg 1260 tttttacaat catcacaaga ttttagaaat ttaacttata acattacaca acagaataat 1320 ttgactaatt taatcacttt aattacatca aatcaatcat tagggatggt tattgatggt 1380 tttaaaccaa ttttaaaaga aattatttat aataatccaa gtattgacca atcagttaaa 1440 aatacaattt gatcaaaaat tgattcaatg gattttaaaa ataatttaat tgctgaaatt 1500 ggacaaatta gaaccttact tgatagtatc tcattaactg aaattaaaac ctataaacca 1560 attattaata aattattaga attaatttct ttaattgaag cacgttctaa aaaagaccct 1620 aaaaattatg gatttattga tggtttggac gaactatttt ccttcttttt aaatttaaaa 1680 caaaatgatc taccaagtag tattaatttt aaaattggtg atcaaaatta tactttatat 1740 gatttaatta ctgaagttaa aaaaattgca aataacttaa ttccgcatga aaaccaatat 1800 gaccctaaag accaacaaat tatcagtacc aattattttt taacaaaaat taaaatttta 1860 gatttgattt ctttaaacaa aaatgaccaa cttgattatc ataagggtgt tgaaatgatt 1920 tttagtttat taaaaaaatt tcaaatagca attcccgaat ttatttataa aattattgat 1980 gaattactaa ttcaaaatac taattgaaat aaagaaaata ttaaaaaact tttagatgct 2040 attttatatc caaaaattac atctaatgat ccttcaatta atgatttaaa atcatatttt 2100 aaatatggga ttagcaagcc tgaaatcaca agtaaagaac ttgaatatga tcaaaacaat 2160 ttattaatta agaaactaaa tattaaatat cgttataaag ttttagctaa tgcagaattt 2220 gatattaaac ctttatttga tttattacca caaaaaccat taagttttat tgatcttggt 2280 ggattatgag aacaaatcaa aaaagaattt ccttataaaa ttgttttagc aaaaaacgat 2340 tatgttgatc atacaattag cattagtcaa ccacaagagt taacaacttt aatttttaaa 2400 gaccgtagtg atcatgataa atataaaatt ggttatgttt tttatccaac acacacagtt 2460 caaacccata tgcctaattc tatgaaagca atcattgaaa atatatcatt aagaaacgat 2520 cgtttattac ctaataaata tgttgctcaa ttattaaatt ggttatttta taaaaaatga 2580 gtattcataa atccactagc gatttatgaa acttttgaag gtgataaaaa gattcctaat 2640 gacaaaaatg ttaaatattt aatcaaagat aatttaaaca agtatttaaa aaactatgat 2700 tcaaatacat attgtgaagg ctttgatttc aaacattttt ctaataattt agaaaataaa 2760 gttggtaatc aaacaattcg taacttaatt ttagctaaaa ttaaaactat taaaacagat 2820 ggtcaagaat tatatcaaga cgcattagga cgaaaaatca ttgcaactag tgcttatgat 2880 caaattaatt taacgcttca agaactaatt gattataaat tgcttggatt tgggaaaaaa 2940 gttgatttaa aaaaagatgt ttatttgagt gcagttgcat ttaattttgg tttaaacact 3000 aacgatagtg atcaaacaaa cgtcttaaat aataatgatg aaattaaata caatctaaat 3060 attttaaaaa aagtagttat cacattacac tttactaagc caatgttaga tttaagtgat 3120 cctaatcgca ctaaattagt taattcttat acttttgttg tttag 3165 28 567 DNA Ureaplasma urealyticum 28 ttaatgttgg tgactgtgat gatgatggtg ttcatgttcg tgaccaccac agcaatcatc 60 tttagttcca ccacaacatt cttcttgggt ttctgatgtt tttgtttccg agtcacagca 120 aacttcatgt tcatgttcgt gaccaccaca acaatcatct ttagctccgc cacagcattc 180 ttcttcaact tttacttctg aattacaaca agcttcattt tcttcatcgc tacagcattc 240 atcttcacaa cagcaatctt cttcataatc atcatcttca ctaaaatgaa tatctaagaa 300 aacttctgat aaatctaata ctgtatcatt agaaattaaa aaagcatcaa tttttgcttg 360 taactcttct tttttaagat caaataaaat gtttgttgat tcaaaatcag cataattaat 420 atacaactct gatcctagat cgcttgtttt ataagcttca tctccaccaa gttctaaata 480 tgaatcaata tcttctggaa gaatattaat tgtacgtgcg ttgtctaaat taatgtaaga 540 aacacctgtt ttaatgtatt tagccat 567 29 1665 DNA Ureaplasma urealyticum 29 atgaaacata agacaaaaaa aataacgctt ttaatagcag gaattacttt aacttcatta 60 tgtacaattt ttgctattac agcttgtagt aagcaaaaat cacaaccaaa tccaaaaata 120 aaacccaata aaattattga gaaaattgat caagcatttt ttaatgaatt taaaacaaaa 180 attgaacaaa aacgcacact tccaaatatt aaaatcactt caacctttaa aattcctttt 240 gagaaaaacg aaaacacttt aaaatcccca ctttttaaaa ttggtgagaa atcggttttt 300 gatttaaaac aaaatgaaat tccaataaca tgagttcaag atttaaaaga ttatttttta 360 tcgcaaaaaa ccattttaac ttattattca ttagcaaatt taaaactaac aggcaatgat 420 gctaaagatg catatttttt agaatttatt caatatattc aaaatatgca acaaaaagga 480 attatatcag aagattttta tcaacaatta tgatatttaa ttagtgaaat tagtgactat 540 gatatgcaaa atggtatttt acgttcagta tatcgtatcg ctaatcctaa acttgcaatc 600 aaggattttt accttgatgg ttcgctttat ggatttaaaa aagaaaaaag taaatacatg 660 aattttacaa gtttgtttca atgaccgaat gcagaagaaa aagcaacttt tgatgttgtt 720 tttaaaaata aaaacagcgc tcagtcttat acaaaaaaga ttgaactgat ttattctaaa 780 gaaaaaaaat ttattttaga ttcattaatt aattatagtg agtttactcc aggtgaatat 840 gaattagtat caattaaaaa acatgatgat atgaatgcca agaatttgat taatcccaac 900 aaccctaata ttgcaaaaat ttttaaaatt aaagttttta aagaaaacga aaaatttaaa 960 ccaataacct taacgtcaat taatcaacaa gaagcggatg aatatgatcg acaaagaaat 1020 caaattattc ataaaaataa ttcagaaatt gggatattag atgattcaaa taaaattaaa 1080 gagttaggaa cttttttata ttttaaaaaa cctttatctg aaattacaat caacgatttt 1140 gatcgttatt ttagaactta ttttatttgt ccagagcaag attttaatga ttttagtcgt 1200 caatataaaa ttactaaaat tgataaacaa aaacaaataa tagaactaag tatattacat 1260 attaataata aaacaaatga aatttatagt tcaccaatta attttaagtt ttattacaaa 1320 aaaatatatg atattaacaa aaacactgat gcacgattag atttaagttt tgatgaatct 1380 aaaaaagaac aaaaacaaaa actacaagag ttagttaata aattaaattt tgataaactt 1440 acttataatg atttaagtga attagctgtt gtgatgtttg aggatgtgga tttagaaaac 1500 actaaaattt atgttgaaat gattaaaaat aaagatcgtt caattacttt aaaagctttt 1560 gttgataaag cttttaaaaa tggaaaatta aaggtaagta ataaaccaga tattttaata 1620 aaagagttta aaataaacta ttttatgcct aattacttta aataa 1665 30 603 DNA Ureaplasma urealyticum 30 atgaattata aatatagtgc tgaagaaaaa caaattattt ataactatat tttaagagaa 60 tatgggcaag tggaccacat tatattttta tcaaatgaac atatacgtgt tccgattgaa 120 tatgatattt tagttattaa aaaacaaaac ttacaaatat taatgacttt tggactaggt 180 gcttttaaat cacataatca cgaagaaaat acgcaagagc gtgctgagat ttttttagaa 240 ttacctgttg attgagattt taataaacat gaaaacatgt gaccagttca ttttttaatt 300 aatatcgtta aatattctta ttcaaatcat ttaacactaa aatgattaca aaccttcatt 360 aatccctctt attttaataa atcaaataaa attgctgggt ttttagattt atcttgatat 420 ggcgagaatt ctttagagtg taaaattaat aatgattttt ttgtaagttt ttatcaaatt 480 ttaattattg atgatgaaga attattctat gcaaaaacaa atggaattcg tgctttaagt 540 aaattctttg atgatggtaa atcaagaatt gttgatttaa atcgaaaatc atttgttaaa 600 taa 603 31 1128 DNA Ureaplasma urealyticum 31 atgaaaatat gtgataatat tagtgaaata aatgatgatc aggatttagt ctttattgat 60 attgaagcaa cagatagtaa gggcgaacaa cgaattattc agtttagcgg ataccgttta 120 aatattaaaa aaaataaaat ttttaatttt aataaaaaat tcaatcctga acaagaaatt 180 aattcacgta ttaaaacctt gctgaacttt aataaaaatt ttaataatat tgaacaaatg 240 ccaaaattag ataagcaagc agcaagagaa atttattgtt ttgttaaaaa tgcgattgtc 300 attactttca cagattttga tattaaaaaa atgcacgagc tttttacata ttataatttc 360 gattttgaaa aaatcgttta ttttgatgtt tataagtttt ttgaaaaaaa attacaaact 420 aaatcagttc ctagtttatt ttcattagga attctaagtg gaattaaaat taattttttc 480 aaattacata atgcgctata tgatgctttt attttaaaag aaatttttat gtgtattcgt 540 cataaaacga acgaagaatt atatgaaatg tatcgttatt atgaattttt gccaaaaatt 600 atttcttctt catattttgt tactaatgaa caagaaaaaa acaggggaat tattaaaaaa 660 gaaattaagt atgtaatgta tattaaagaa tttgatttct caaataaatt taatttagac 720 tttgttgttt ataaaaaaga tcatcatttt tattcaaaac caatttatga tagtagttta 780 gaattgcaaa caatttcttc actaacttcc aaatctaatt ttatgaaagt taaattagca 840 aacatctttt ttaattattt aagtaaaagt gctgttttta gtataaaaaa actatcaata 900 aaacaaagtg aaaaattctt aaaattttat aaaacacaga ctaataaaag aaaggttatt 960 aaagttttaa atttaaatct taaaaaagaa attaaacctg agaattttgt cataaaagct 1020 caaataattt gtgaaatact ttttaaaaac ccaataattc atcattttgt acatgaatat 1080 ttaaaaattt ttcaaaatat attttctcaa gaagaaaaag ataattaa 1128 32 3255 DNA Ureaplasma urealyticum 32 ctatttataa atatcttcat atttttctgg atataaatag gctaattgtt tgatttgttg 60 aattaaagat gtacgattag cgaaattgtt tttatctcca aaaaatccag aaattagaga 120 atcaaaaaca atcatacctc cggctgtaaa ttttgcattt tcatgggcgc caaaagaaat 180 cattccaact aaatcaccat tttcatcata aactactgat cctgatgaac cagaaccaac 240 atcaaaatat tgattactaa ttttagttgt ccctactgtt gataagtaat tattagtagt 300 aataatattt tcttggattt tatcatattt attaatttca tattcacgat agcgtggaag 360 tttgccagca ttaaattcat taattgtctc tgttctaggg aaagttgaca agtatcattt 420 tacattttga ttatcatcga aatacttagt ttgattactt aatttcaaag gttttagatc 480 cttaaaatta attatatgtc taataacact ctgttgttct tttgttaaat cattaaaagc 540 aggtgaattt tctaattgac catatttttg aaaaaaaggt tttaaattaa tggtaattaa 600 tgaaaaatct aaacttgcat taggattaaa aaaacctaaa gcgttaacat gaggggataa 660 tttatttttt acttgatgat caaaattaat gatcgattcg atactaattt tttcaggaaa 720 atttaaaaat tgaaattgat tttgattagc ttcaagtttg ccattttttt caagtgcatt 780 gtaataagga ttttttttat catttaatgt ttcattttca tgaataattt ggggaactag 840 tggatcaaaa tctccattag aactattact tgattcaaag agatctttat tacctgtttt 900 gttaattgat ttaaaagctt gcgtactatt taaaacatga gcacaactaa ttagataata 960 gcgataatca tcatcatcat taggtttaac cttccctaga acatttcatg taccatcttg 1020 aattaaactt aatgaaatta cacgatcacg agcattttta attggtaaaa aattctgttc 1080 attgttttta taaattcttg ttgtatattg attattagat ttatcatctt ccattatatc 1140 tatagtagta ttatttaaat aataaatatt aaaattagcc tttgttaaaa aataagatga 1200 atctattgaa gaattatgtt ctcaaatatt atcaaaaaca ctaatgttat ttttagaaat 1260 aattttaatt tttaattcat catttatata agatatttga aaacgaaaat cttgcttaat 1320 ttttttgtag agttcatatt cgtactcttg atttccaata ccataattta aaacaaattc 1380 agcatcttca ataacttttt tattttttaa agttttataa gggactgcta atgaaatttg 1440 agaccttaac ataaggtttt ttcacaggtt agtttctttg atgagatttg gatctaaacc 1500 aaaagtaata ttaaaaacta aatttttttc atttacaaga tttaaatttt taatcttatt 1560 tatttttttt gttaattgaa aataattatc tttatctttt ttaaagatca aatctggatt 1620 atcttttaat gtagttttat gtaaattttt gatttcatta ttatttacaa gtataaaatc 1680 agctttttta gttatgaaat cataaaaacc ttcgtttgtt ttattttgat aaaataagta 1740 ggtattttca tattgaacta atgaaataaa atttcgcaat gaataatcta aatataaatt 1800 attttgatta gatgctcaaa gtttatataa gtcatttaaa gttaaatttt tattctttaa 1860 agtttgatat tttgttgaaa aaaactgatt attattgtaa tacaaatcaa taattttacg 1920 atcattatat attatatttt ttacaaaaaa agtacttgta tttaattctt ttactttaac 1980 aaaagcaaaa ggcgttaaac tattattatc acgaacacta attctgttta atttgtataa 2040 atatccatta tataaatgag ggattttgaa ttttcatagc gatttaaaag gaacacgaac 2100 atactgaatt ggtggagtat attttgcaat taaactttga ttttttttag cttcgctata 2160 attttcgtct agagtaaact caaataaaaa aatcttgttc ttatataatt ttaaagtttg 2220 ttcattaaaa tcaaaaaatg ctgatccata tacttcattt tcttgcaaat agaaattaag 2280 ttttttgagt gttaactctt cttcaatttg attatataaa aataaatttt ttaaatcacg 2340 tcctagtgat tctacaacat catcatactg aatatgagta atgataaatt ttgttaatga 2400 tttaggaaaa tcttttagtg aaaagcgtaa ttgattatta ttaatttttt catatgaaat 2460 aattttgcta aaaggattgg ttcaatcaaa atttttaatc aaaagacgtt tatttgtcgc 2520 atttaatatt ttttgtattg tttgtgaatc agaatcatga ctaaaactaa ctgttgcaat 2580 ttggttttgc ttatctattt caattttttc aaatttaaag ttagtgtgat gatctgttag 2640 ttggttttgt tttgttaaga gcgttgcttg attaaagggt agttgtttaa aattatcttc 2700 attttgaata aaattaaaat aattattaaa ttcttggtta tttttctgca ttgttattaa 2760 agaaagatca ctagtttttt ttatgttttg cggtgaagat aataattgtt ttaatgcaaa 2820 aggacgataa tcattattta ttaattcatc attaatatat tttgtttcaa taacactttg 2880 cttcttattg atttctaagt tttgtgtata ttctttagtt tggttatgca aactgagttg 2940 gtattgaaca aaaaaattat ttgacttttg ttcaataata acttttttaa ttattatttt 3000 agcttgcccc aagtcaccca caactttaat tttattaatt ttaattattt gctcatcttc 3060 attttcaaaa atatcatatt taaatttaat gttttttgct attatgtcta aatttttagt 3120 atcttgattc gtaattgtag aagacgaaaa tgtttttttg ttataagaac aattagataa 3180 tgatatagtt attgaaccaa gaattattgt tgatacaaca cctattgata agttttttaa 3240 tatttttttt tgcat 3255 33 306 DNA Ureaplasma urealyticum 33 ttaaatcttt ttgttaatta ctttcttttc tttaatcttt gttattacta ttattataat 60 tggtgttatg aatattaaaa agcaaataat tgttaaaaca attacaccaa ttaatgctga 120 ttcataatga tttgagtatt caaatgaatt atcaatttta ttatattggt gtaatttatc 180 taaaaaatta agatatttca aataatcacc ttgatgataa taatcaattt cgattccaaa 240 aataattgca aaagccaaaa gaatgcaaaa aactattcct aaaaaagctg acccaataat 300 cttcat 306 34 807 DNA Ureaplasma urealyticum 34 ctagtttgcc tctaaattta aatttatttg ttgtaaagaa ttatttaatt ttttagcctt 60 tttttgattt ttaacttcaa gttttgcaag tttataagct tgtttttctt cagcactttt 120 tttaggtgaa aatacagtcg ctagtttaac aacaataatt ataaaagtaa tcatttgtgg 180 catcataaat acaataaata ctcaattata tgcaatataa tttggatttt gatattgtat 240 aatggttgat aattttgcaa gagattttat tccttgagct gctaatacag gattttgtga 300 gttagctaat tgtgagaata attgattata tttgtaaaat caactatttt ctcaatcact 360 taatactttt gttacaaatc ctcatgttcc attatgatta ataaatttac tatgcgcatg 420 ataatgaaga gcttcatata attttggatc gttattttta ttagtattat taattaatga 480 ctccattgtt tttccattaa tcaattgatc gtgaattgtt ttatacaatt cttgataatt 540 agcgtgttga tcataaccta atcatgacat taaagaatga ttatcaccac taacatcagc 600 tactttacca ataatttgac cttgatcatt aactaatgct cttgcatttt caaaaccttc 660 atttaataaa ccaaccattg taaacgctat tgttaatcct actataaata taactaatgc 720 tgctataaat caaggcgtaa agacttgttt aatttttgga agtttgctga attcagcaaa 780 gcttttattc attttaattt gattcat 807 35 711 DNA Ureaplasma urealyticum 35 atggatgaac aaatttttat tcaattatta gaaaacaatc taacaaattc aaaatcatat 60 gtgactcaac caataatatt agaatttaaa acggatgttt ttttgattat aaatcaaatt 120 ttaaaacaat ataaaaaagg taaaattatc aaaaataata caaatgaaat tattttagaa 180 attgataata aattaatttc tataacaaat ttagatatca ataaatttca ttcgtatcaa 240 attgttaata ttaatgaaaa taaaaatatt tataacgaaa ggaatagttt aattttattt 300 gatttagtaa attatatcat tgaaaaaaat caaaattcta tcagacacat taatttttga 360 acgattcaaa tgagtgtagt taattgaatt tattttatta cttataattt taacaattca 420 tatttaattg atccaaattg aaaaaaatat gtttttaaaa ttaaaaaaga tgaatctaaa 480 ggtgtaatta gtaccaattt attacataat tatggttttg tggattttgt tgtacagtct 540 aaatcacaga attttttaaa agcttatcgt gttcaagatg aaattctaaa atctgtttta 600 aatttaggcg ataacttaaa taatgaattt ttagaagaaa tcatgagaaa atatgataca 660 tacaaaataa ttgatagaga tcataaatat ttagtgatca atattgaata a 711 36 732 DNA Ureaplasma urealyticum 36 ttatttttta tttactacat tatctaattc aataaaattt ttaataatgt ctcttccttt 60 ataatctatt ccaacaattt gtttagcaat tgctgtagct acttttatag cagattcttt 120 tgtcttttta attttttcat cattggcttg tttattatca ttaaagtcga ttggattttg 180 ctctagatca attggaaaat cagcattaac attgaattgt ttatttaaat atggtaataa 240 ttgttggtta aaggcgatat tagccatatg atacttagca tttttgttta atttttttac 300 aaaagaaaca atagatgaat tcattaattg tgatttttta atttcaacaa ctgaaatttt 360 tgttttatct gttggtgcag caagattgtt ttctactttt tgatctttat tatattcgta 420 gaaagttaaa cgtaaaattg ttggatcaga tatatcaatt aatttattag tattagtgtc 480 taacttttta aatgcaatat tttttagttt ttcagatata tcaaaaccta atccaattga 540 aaatttagct tctactttat cattagaatt tttaatatca ttggttgata gatgtcgaaa 600 tgaaatatga ttttgttcaa tattattaac attatcatta tttaatgcaa tatttgcaat 660 tttaacatta gtcaatttaa catcataatc acgattatta aactttatgt atatggtttt 720 atggagcgac aa 732 37 627 DNA Ureaplasma urealyticum 37 atgataaata atatttttaa taaaaagttg ttagtttaca acgaaaaaga tcaacgttgg 60 tataacaaat ttgatagaac taaaccttta ttttcaccaa gtagactatt aagttttaaa 120 aattacattt ttgaaaaaat accagcaaaa aatctagaat atccaattga gtttggaact 180 agtttaatgc aaatcattca atactatttt gaaaatcaat caaaattaga tgtcatttta 240 aatagtatta atgaagaaaa attaaaagaa gtctttttat tgtttttaga ctatttaaaa 300 acaaatgatt attcactaat cgctgttgaa ttacatttat ttagtccaaa actaaaccat 360 tactgacatg gttttgctga tgttgttgtt aaaaccaaag atgataagta taaagtactt 420 gaaatcaaaa cacacaacga aatccaatca gtgccatctt gaaagtttca agctggtgta 480 tatgattaca tcatcagcca agaattaagc aattacgaac catcagctat actagcattt 540 agtcgtaaac aagcaaagtt aagcgtttat gaaaatgatt cattagattt aagttttatt 600 aataaaatca atgaactata ttcttaa 627 38 174 DNA Ureaplasma urealyticum 38 atgaactata ttcttaataa aaacaaaaaa gtaagcttaa ctgaactaat gaatcaacaa 60 ccacattgat acttagaaga actacaagaa catttaatta aatatcttga tacaaacgga 120 ctaaacgaca ctaaaaaact aattaaacaa acaattaaag aatggaaaaa ataa 174 39 342 DNA Ureaplasma urealyticum 39 atggataaaa ttaaaaatta tctagaaaaa ttacaagcgt tttataagtt atattctctt 60 aatttaactc aaggaacaga aattttaatt attcaaatca ttgataaagg taatttaatt 120 tttgattcca ttgaaaaagg taaaacattt aacgaaagta aaataataga accactttta 180 ttcattttta aaaaaataaa tacaatttta gctatcttaa aattaacttt tactaaagat 240 gatttaattg gaattctaca atcattagaa gagcatatat cagaatttat tattgcaaat 300 tataaatatg attttgaaat cgaagaagat gatgaagatt aa 342 40 297 DNA Ureaplasma urealyticum 40 atggaaaaaa tagttggctt tattgtgaac ataattaatg ttcaaaaaca aatgataaaa 60 gacttaaaag aactaaaaaa tcataaagac atcatggtaa aagaccatga aaaattaaat 120 gatatgttaa atagtatgat agatgaagca gttaaaaatt acaaaattgc attaaaaaac 180 ataacagaaa ttctaaacgt tcatttaaac tgtgttttat ataatcacaa tcttaaatgt 240 ggcgtaaaag atgaaaaatt attattacca ctatttaaaa gaaagaaagc gagttaa 297 41 237 DNA Ureaplasma urealyticum 41 atggcaatgc tttgtatgtg tgatgaatgc caagcaatta ttaattatta tgttgtacaa 60 attgaacaat tgtgtaacga aattgtaaaa acaagaaaaa gagttgaacc atataaaaaa 120 ttgggtaaat tgttttttga aattattcaa aatgatttat ttgaagcaat agctgaagaa 180 gtgtttagaa tagatgaaaa accaaaacga aaaacaaata aaagagtatg taaataa 237 42 183 DNA Ureaplasma urealyticum 42 atgaaaaacc aaaacgaaaa acaaataaaa gagtatgtaa ataaatttaa agatttgcgt 60 aatcaactaa caaaaaacaa tgacgttaaa aaagtttgcg atttaattaa tgatttgttt 120 tttgaagtat ataaaaacaa tttaatagat gaagttatca aggagattaa caaacatgac 180 taa 183 43 264 DNA Ureaplasma urealyticum 43 atgaagttat caaggagatt aacaaacatg actaattgag ataaagaaca tgcattaagt 60 gaagaactaa gacaattaaa agatgagttc gaagatttaa tggatgattt agcaagaatt 120 aataaagatt tagattttaa tatctgagaa cgtaaagact tagaatatcg taaagcaagt 180 tatgagacag atatcgaaag tattagatta cgaattaacc aaaaacaaaa tgaaatgatg 240 gagataataa aaaatgacaa atag 264 44 336 DNA Ureaplasma urealyticum 44 atgacaaata gtattaaacg tgaaatatta agtgctttaa atgatgaaac aaaaaaagta 60 attagcaaat tacaacaaac aaataattta attaaacaat taagcgatga aaaaaagaca 120 ttagaacaat atttaaaaga taatgttaac aatcatgaaa tcgttgattt agacagtgat 180 ttaaaaatta aaatctatga tttaacatct aaggatagta ttgttttaga ttatgacaaa 240 atcattactg attataaagt tgatacaaaa aaatatgaaa cgattaaaaa aggaacaaca 300 tcaacacgaa taacatgaag tggagcagat aaataa 336 45 657 DNA Ureaplasma urealyticum 45 atggttaaag acgataaatt agtgccaagc attagattat taacaccaaa tgaactaagc 60 gaacaatgag ctaatccaaa tagcgaaatt aatcaaatca cacgtgctgt tttgaccatt 120 caaggaattg atttaaaagc cattgattta aaccaagcag cacaaattat ttatttttgc 180 caagcaaata atttaaatcc actaaacaaa gaagtttatt taattcaaat gggcaatcgt 240 ttagcaccaa ttgttggtat tcatactatg acagaacgtg cttatagaac tgaacgatta 300 gttggtattg tacaaagtta taacgatgtt aacaaaagtg ctaagacaat actaacaatc 360 agatcgccag gtttaaaagg tcttggaact gttgaagctg aagtattttt aagcgaatac 420 agcacgaata aaaacttgtg attaacaaaa cctattacca tgttaaaaaa ggtgtctttg 480 gcccacgcat tgcgtttaag tggcttatta gcgtttaaag gtgatacgcc ttatatttat 540 gaagaaatgc aacaaggcga agcagtgcca aataaaaaaa tgtttacacc accagttgct 600 gaagtaattg aaccagcagt tgaaaatata aagaaagtag attttaatga gttctaa 657 46 690 DNA Ureaplasma urealyticum 46 atgagttcta ataactttga taataatatg ccacgtattg aatttaaaaa aatgccacta 60 acttttatta gattaaatac gaaaaaaagt aataacgcac cctttgtttc aggtagtttt 120 tgattagcag ataaagtaaa tgcgaacgtt tattttagtg aatatttaat ggaacgtatt 180 gttccatttg aaaacaataa aactaatatc gttatcttag aaaatgtttc atgttatata 240 aattttaact gagaagaaaa acgaattatt atgcgtgttg tttcatttga taatattttt 300 tacaagcatc aattaagcga acaacaaact attgattttg tgagtgctga aaaagaatat 360 aactatcaaa cacaaacagt taattcttat agtaatagtg atgatgaaat tgaaattatt 420 aactgattag aaagtgatga acaaaaagca tattttgata gtcagttaat gtttattgat 480 tataaaaacc aaggcttttt taaaaataaa acaatgccag ataaactaaa aaataacgct 540 aatgctttag aactttataa acaaattatt aaattagatt tagaagcatt tagtggttta 600 tacaacggct taaaaccatt tgaagcagca aataaattaa ttgaaaaagg ctatataaca 660 cttaacgatt tctttaaata tgcgatctaa 690 47 462 DNA Ureaplasma urealyticum 47 atgcgatcta aacaatgaca tttgagcaca caagatgcta atttagcaaa taaaaaatat 60 gattatattt actttagggg tgttaatcaa ctttatttaa aacgtcttaa aaaaagtagt 120 aataagtttt ttgtttataa aaaatgtaaa atcgtaccac gtatgatatc aaaacattta 180 aataacgacc atttaattaa cgttaatgat tatgtaccac taaccaaaga atttattaaa 240 aaaagcgttg aaaaagaagt taaacattat ctaaggttta tatcttatga aaacaaaact 300 aaacaaatgc ctgaactaat taatttttta gaaaaatcac ttgaagataa gttatttatt 360 gtcgcaaaag attatgatcc tttattttct gtgtttttac gttattacat tcaaagttta 420 atagaaaaat atattaatga attatgaata aatgagtgat ag 462 48 678 DNA Ureaplasma urealyticum 48 atgaataaat gagtgatagg aatcgattta tcaacaacaa taacaggagt tgctatttta 60 agaaatgagc agataattaa aacctttgct gttgcttttg ataactttaa tgaaaagaat 120 ttatataaca acgttataag acttattaaa gaaattaatt taaatgtttg attattagct 180 gatgatgatt attatattgg tattgaagtt gctaactttt caaatccaaa actaacacag 240 cgtttttcaa tttatgctgg tatgattatt gcgttaatgt cacaagtttt aagagatttt 300 aacgctgaat ttaaaatgtt taatgcgaat gcttgacagt taaaaatacc acaaatacaa 360 tataacacat tgcgtaaaga tcgtaaatta attactaaaa atttaatgat taaaacattt 420 aatattaaaa gtaatttaaa cgaagacgaa tacgacgcct tagcgattgc ttatttttat 480 gatagtatta attcaacgct agaacaagaa gagataacta aggctaaaaa aatagttaaa 540 atgaataaag ttaaacagca gttatcaatt agtaaaaaga ttaataaact gcttgaaaag 600 aaaagcaaac taaaaaaagc aactgcgata tcaaaagttg atgaacaaat agaagaatta 660 aagaaactaa ataaataa 678 49 444 DNA Ureaplasma urealyticum 49 ctaataatcg cttttaatac gttttaaata ttcgatctct tcttctaatt tgcgttgttt 60 acgtcttgat agataactat gtctgatatc atcaataaac gcctttggat ctaatatacc 120 atccttaatt aatttggcta gcattaatct aaatcttagc attagcatta attcaaatac 180 ttttaatgga attgataacg ctgttattaa atatccaagc actgagaaca ctaaaccaaa 240 taatgcggtt gggtcttgtc agttgatgtg ttttaattta tcaaacaaac tcttaatctt 300 gtcattgaaa ttaaaaaatg gtacaaacac aataatcata gcaaacgcaa ttacaaatat 360 taaaatagca attcataaca tcaagcgttt tttattaaag aaaaataatt ccttagtaat 420 cgctttgaac tcttgttttg tcat 444 50 549 DNA Ureaplasma urealyticum 50 ttagtaatcg ctttgaactc ttgttttgtc atcttttata atctcctgtt ctaatcgctt 60 aactttttgt tcttgctctt gtatttttaa ttgcttttct tgttgttcta gtttttttaa 120 ttcttcatcc aatgttttgt aattgttaga acttataact gctttaatat tttcaacact 180 aatataacga ttacgtattt gttcaactag tatatctaag gcttcgaact cttctttact 240 taaatccccg tactggtgca ttttagcaac agttcgccat aatgttttta atgttggtaa 300 aagtgttaac attgaaataa ttaaattaat aaatccaata gtcataaaga atggaaaata 360 aaacttttgt tcttttacaa ataacacaaa tgcgttatca tttggtagtc cagcaattaa 420 ataagtagat aataaagcta atcctaaaaa taaccctgaa ataattgaac ttgttaaata 480 aatcagctgt acttgttttt tagaaaactt ccattctttg tttttaaact tatttttatt 540 gttcatcat 549 51 437 DNA Ureaplasma urealyticum 51 ttattgttca tcatttaaaa tactctcctt attttgcttg tataaatcat tttgagcctt 60 ttttatgctt cttttttgtt cgttaatagc ttttcattca ctttttagtt tgtcttgttc 120 tatgcgagtt tttagatgtc agtttttgcc ttctgttgta aatcgtcaaa agaacggcga 180 tattgcgaaa aaatcaacgc aaccacaaat gatataagca aataaaacaa ctaaaaataa 240 ttgccatttt ttcgtacttc ctagttttgg aaattttgat atcattcagt ctcataatgt 300 ggctttgtct gtatattcgc tttctttacc aaaaaataca aacgatgtct caccaatttt 360 aataaaaaac gaacaaatta aaaaaatggt tcataatgtg gttagaattc atagtcataa 420 aatacgacga ttaatat 437 52 336 DNA Ureaplasma urealyticum 52 ttattctcct acataaattg ttctaacact tcattcataa tttaatccaa cttcaaagtt 60 tgtagcaaat gttttattta ctatatctat taatcacaaa tcaacattaa caccagattt 120 ttcagcatta acacgaacga ctaaaaattg aggctgatat tgatttcaca acaggatttg 180 ttgttgtgtt tctccactat cagataacat gttattacgg tctgtgtttc tatcaaaaga 240 aaacgttaaa ctataatctt tatcacttca atcaacacta ctgttattaa aatttaatga 300 tagataccat ttaaaaatta cttcatgatt tgccat 336 53 1374 DNA Ureaplasma urealyticum 53 ttaaattatt ttatttaagt tatccataat ttttcacgga aacctaacat tcctatttag 60 tgcagtgttt ttaaaacttt ctaaattaga tgttaaagca tcaacattag cactatcacc 120 tttttcaccc tttggaccag tttcaccttt tggaccaatt ggaccttgta ttccaggttc 180 gcctttttca cctttaaata caccagatgc tttatcttgc tcataagatg ataaaaccgc 240 ttgtttggct tcattaactt tattttctaa gtttttagtg aatgtatttt ctttagtatc 300 aattgctttt ttaacttcgt ttactttatt atcaacagca tcttgcacgc cttctttaat 360 tttgtttaaa tcaatttgtt gaatattaat taattctcat acattttcgt taatttgctt 420 acttggatct acgatattat gcgtacttac accattgtta actagtgcct tataaacttt 480 aattgtgtta gttttttcat ctaagtcata aactaactca ccagctttat agtcataaat 540 agcatcccag tacattttgg aattaatttt attacaatat tcatacaatt cttggcgtgt 600 aattgcattg ttattatttt gtccatatca tgctaaattt ttaacgtcat gaatatcaac 660 ataattagca atagcattat cataaacttt attgctttta tctgttgtta aatcatttgg 720 tagtgtacaa tcatttaaaa taaagccatt taatgttgct aaattaccag atgcgttaat 780 gctacttacg ttattaatat tgtgatggtt taaatcaaaa ttattattaa caacagggtt 840 atttttagat atataatggt ctcttaattc ttcatgaaca ttattaatcg cattaatttt 900 taattcatca taattaacat aaataccatc atcgttaaag ttagcaaact ttgatttttt 960 atataatcca caaacacgta atttattaat gatatctaat cgcttttttt caaaatcagc 1020 attttcagat ttaaaagata atgataagcc atcaccaata gcagatgtat aatctttatc 1080 gataaaatga ccttgtaatc ataaataatt tgttaatgtt gcaattgctt ctttaaattt 1140 agttttttga taatctgttg tttttaaatc atcaaatcaa ctataaataa aaccagcacc 1200 accatttgat gctacacaat catcaatcat tgattgagca cgcaaaataa acgtagttaa 1260 cgcttgtttt ttacgttcta attgtaattg gttatcttct aaattttcgt ttcgtacaat 1320 tagtggaaac aaacttaaat attcttctac actaagtaat aatctattat tcat 1374 54 783 DNA Ureaplasma urealyticum 54 ttatttaact ccttcaaaat atttacgaga tgcatcaaat cagtaaatac tttctttttg 60 taagtgaatt aagtttttac gattagcatg gtaaaatatg tttcaaaatg ttgtaccagt 120 tggtgcaaat ttcagcattg tagcaatgcg ttttggaata ttacgtcatg tataacgtgc 180 tagtggatta cgtttggatg gtttcattaa tttaagtgtt aaataaccaa tcttaccaac 240 gccatcactt gcgtatcatg tgccataatc tatccaatgt ttattaaaat caatgtcaac 300 attatcaaca tctttaaact gattttcttt acgcactttt tcaaaattct ttttttcagt 360 tttagatgcg ttatctaatg tatctgttaa atgtttgata atgctatctt tttgttttgt 420 cgtgtattta ctagtttgtt tagcaatatc tttaatcgct tcattaatag catcttttag 480 ttttttagct aaatctttgt tatcttgaat aatttttaat tcttttgagt taaaaatctt 540 ttctaaactt gaattatcaa aaaacttttt taatatgtca tctggtttta aattaaagtc 600 atgaaaaaca gttttacctt ttttcataaa agcaccagtt ttatttttaa acattttaaa 660 aaaatcaaat ttaaacatct ttaacatacg tgaaaataag ttaatcaaag tagatattaa 720 actcttaatt ttagataaca acaagcgacc aacaaagcgt agtattagaa ttagtatacc 780 cat 783 55 1188 DNA Ureaplasma urealyticum 55 ttacttgtaa gtacttaaac cccttcaatt tgctttattt acttcagtga ttttagaatc 60 ttcactgatt ggtgttttaa attcagcata tagtgaggga aattgtgaat aaagatttga 120 gcgtgcttta ttgatttcat cttttgttgg tttatcattt aaaatcacaa aatttaaatg 180 tgcaaattgt ggaaagaccg cactgttcat acttcatgag ttatgaatta actggtgtga 240 tttgcttgtt ggactttgaa atgttgttaa cattaattct tgttttaaac aaattgtagt 300 ctcaggcatt gtaataatac cgcttagttt gctaaacttg taatcacgaa ttaaattact 360 tgtgtatttt tgatctgttg attttaaata atcttcgcct aaatatgcag atgagtatat 420 tggcattcct aaataatcac ccatatattg tgaactactt cctaaaccct tagtgctata 480 gtcgctgtat gcttgaccat cacgaatttt ataagtttta gcagttaata caactaatgc 540 tgcatcatct gataaaacga atcgtaattt atttggatca gctcctaaat taaatttagt 600 acgacttttt gttacttgtt ttgctttacg atatattttt tcaacaattt ttaatcgttc 660 atcatctgtt aatgattcaa cacgatcagg actaagttct ggaataataa tataattacc 720 agttgctaaa caagattgat aaatcgcatc aatgttaatt aaattaattt gatcttgttt 780 aacgacttct aaatttgcta atgtcttagc taaaaaatcg tttcattgag cacctgtttt 840 tttatcaaat acactaatac ttacttcttt ttgatagtca ttacttaaat gtaatgttaa 900 tctatcaatt gctggtactt gcttttgtgt aaagtcatca cggtactctt caacttgtcc 960 gattacgcca acttcataaa tagcagttcg catatcatcc ataattttag ttggtgtcat 1020 tgttgcactt cctagaaatt cagcgttaaa ttgattttct agcatatatt tttcaaatcc 1080 acctgcaaca acacgttcat tattagcgtt aacaacatct aaatattgag tgattgtata 1140 tttagcattt ggatctggtc tttttcaagt gttttggtta tcagccat 1188 56 327 DNA Ureaplasma urealyticum 56 ttagttaaaa aattttaaaa agtggctatt agcatcttct acgactggtt tttcttgatg 60 aatattaaca aactgttgat tttgttcaag cgttgcgatt ttgtttaata attcttgttc 120 tcgttgctta aacgtatttt ctaagtcttt gatttctttt aacttagctt caactaattt 180 attagcatta tctaattgtt catttgtttt tagataattt tcaaattgtt tttgaatacg 240 tttgtcaatt tcatcatata aagcattttc tttattttct tcagtttctt gtggttgaac 300 ttgatttttt tcaagttcat caaccat 327 57 699 DNA Ureaplasma urealyticum 57 ttactccact aattcaattg tttttaattt aatggttttt gatttaatac agttatttgt 60 ctctaattct ttaataacat cgcttaaatc aaatggtgtt gttttaaata aacgtcgttc 120 gttatcttcg cctttaaact catcaattgg tttattattt ttacttattt ctttttcatt 180 acccctatca tcaatataaa tatttgcctt attagcatcg cttaaatcaa atggtttttc 240 aattttataa gttggtaaat aatttgaaac taaacgataa ttaacacgat tagttggctc 300 gatactataa acaatatctt ttgttgtact ttcataatct tttaattcaa ttttaaatgt 360 gttttcatta attttagtta agataatata tttgttttca tttggtttaa cactaacaga 420 tatattctct ttattatcaa caacagaatt aacactaaat tcttgattaa tagctacaag 480 attaaattct aatttatcat caacttcacc taaattaata tgtattgaac tattgtttgg 540 ttttgaaatt agtaaatcat aaacatcagc tttaatacta aatgtactaa ttgttgattt 600 tttatttggt gtgtttaaat ctactgcata attaccacca tattttaatt tattatcttt 660 tgttagttca aaaccaacaa agttattagc tgattgaaa 699 58 2835 DNA Ureaplasma urealyticum 58 ttagttcaaa accaacaaag ttattagctg attgaaacta ttatcaacgt taaactgatt 60 tgttcatcct ttctgtatcc aattactttc aatctcaaat gttagtttta aattacgttt 120 tgttttatta actgaaccta aatttaacca ttcacgataa ttaaaatctc atttaaacac 180 aaaactataa gcaataactt tattagcaac aattacatca cttaaattac ttccaccaaa 240 taaataattt agtttattag tatatgaacc ataaccaaat agatttgcta atttagaact 300 gtctggttca taaaaataaa agcgtggttt tctatattgc gtagcactta ataatgaatt 360 atcgcccact ttatataatg tttcattaat tgtttgtaaa cttgcattaa ctccatcatc 420 actatttgtt ttagtatttt ttaaaaaatc agtttcaact ggtggctttg gataacttag 480 tttagttcca actgaattaa tctcatcaag cgttgaaaaa ttaatatagt tgcttcattg 540 actcatatca tcagtatatt ttccattgct ttcaaaaatc gcttcgtaca cgtttttaaa 600 ttcgtctttt aatcgtgcat ctggtgaata aaagccacta aaagctgtta gtttaatatc 660 acacttaccc aagcctttaa tatcaatcgt atcaattaca taaggatatt taacacgatt 720 aacatcttca cgtttaccag acgctatatt aataacagct ggttcataac taagcggtgt 780 gtttggtggt aatgcttcac agaaactatc tcaatataaa ggttttttat cttttcttat 840 atacgtacca tcacgatatg ttgtttgtcc aattagttca gtatcaaata cttttagctc 900 atcatctaca aatttagcaa atctatcagt tatatcaaaa tgataacaac aagcaatggc 960 tggtatgcca agtggactaa atgttttagc tggtttgtta gtgaaaatat ctaaattaat 1020 taaatccgct tttagtttat ttgatacttc taattcaagc ggtaaacatg gtgcaataaa 1080 attaaaacca cgtgtattta atcaaatgtt tgacatgtta taacctgttg cgtcttcaac 1140 tttggttcaa ccaggatata aaatatctac aataccacgt ctaactttac ctaaactaag 1200 tggtgtatta tctattaatt caccaagatt ttgacggatt gtttccttgt atgaatatgg 1260 taaatactta atcaaatcat acataaatgc attgtgattt aaaaacgtat gcaaattagt 1320 accaggtggc attgtaatgt tgtttaatcc aattttagtt gcttctttta tttgttcagc 1380 tttggtttta gcaaatccca tattaaaaga ccataaacct aaattattta aattaaatcc 1440 ttgtgaaaca ttacgtccaa tactttcaaa cactgtactc acaacttcac cagcaacttg 1500 accagttaca acagcatcag ctaacggctt tttttgttct gcattttcag ttaatgatcc 1560 gcccttttgt gctcctgttc cacctaattt aaagttaaaa aagctcgcat gtattttaaa 1620 accttcatct cataatttaa atggataacg attgtcttca taacttagtg cgttattgct 1680 tgcgtctcat ttatgattta ataataatcc accatttaat ttaatattag cgttatggtc 1740 aaatgtaaaa tctttttgtt tttcatactg gtctttataa atcttttcaa tttcaaaaaa 1800 cgcattgtat aaatatacat aattacttgt tggtgctgat acattaaaga atttagatgc 1860 gactggtatt ttagctttat atagtaataa tcgcttatta gcacttaact ctcgtgtgtc 1920 attattataa gttcgtcctg ttattaacat actatttaat gcatatggtc cattagttaa 1980 taattgaata cttttaactc ctaacggttt ttctttacgt tcatcatatg ttaatttacc 2040 attttgaatt actggtcata aataaccatc tccaggttga catggttgaa ttgttgctaa 2100 tatatcatta ccagatgatg ttagtaaatc gttaacgttt gttagtgtaa tttgtgctcc 2160 ttcataacgt tttgatgttg ttgaataaaa aggaatgact tcattaacca ttaatcattg 2220 attagcttgt gcgtgttcat ctggaataat gaataaatat tcttttaaca tatctgtagt 2280 tcattgttta aactttgctt tatgactaac taaattacct tgttcatttt ggtatatttc 2340 atcttcataa acacttggat atttaacaat taaagtaact gttgtaattg ttttaataac 2400 tgtatgttct ttatcattaa aaacaattgt agatacatta tttgcttggg aataattttg 2460 tactcatgct tgaaaataat aaggtttaaa gttgtttttt agcgttgtat tacttggatc 2520 aatacgtgcg taatctttac taatgtaatt taaactacct ttaaagttat acgtaaatga 2580 tttatctcaa tacgcaatga ttggctcatt acttgcttta atatttcaaa cagtgctaaa 2640 atctttgtca tttactaata atgattgttc accggtgttt gtaattttaa taaaaccttt 2700 tagtattcta aatggacata aatgaattgg tttttggttt ggttcaatta aactatcaat 2760 gctgtcttca atattttttt gactataacc ttcaagttca tctaaataaa tattactcat 2820 tttcaaactc tccat 2835 59 360 DNA Ureaplasma urealyticum 59 ttactcattt tcaaactctc cattttctag tttttgttta tgttctaatt cttttactag 60 ttcatcttgt tcggtaggtg taagttctgg atataatttt tgtacagcta aattaagtgg 120 cattaaatta gcaccatata aactaatgac tttttccata ttatcgttgt aatctttaat 180 taaattacta ataattttaa attcaacata ttgatcaaac tcttgacgta ttagtttatt 240 aacttgtttt tgttcaattg agcttaaacg cttgttacca taacgttttg ttttaaatca 300 tgcaatcgca atatttttaa aaaaatctat tcaatcattg gtgtatagtt ctactttcat 360 60 561 DNA Ureaplasma urealyticum 60 ctactttcat ttttgcgttt caaaagttgc tttatttaaa ttagttgctg tttcgctatt 60 ttgatagctt aaactatcgc ccatatttca tacataacca caacctttaa agattaaatt 120 taatttttca gtaatggctt gtaagtgaat actttcgtta aaagtagatt gcataatttc 180 aaatgcgttt ttatctggtg tgtttgtgtt taatatcaga tctgaactca tgtactgtat 240 ttcatcaatt cattgattac gataagtttg tgcgtcattg tgattaataa ttgatccaac 300 gattcgtgtt ttgtttaatt cacgttcttt tttaataaag tttaataaag cattagtatc 360 attgattaaa tcattaactg gatatcaatc tggtaatttc tcattaattt tattttcaaa 420 gtcaataaat gaacgattta aaaactcttt tgtgcacaat acgccgtagt tgtgtacgac 480 gtttttgttt ttaaaaatat ctttaaaata cattggtgta gaaacttcaa attcattaaa 540 aataatttta tatacaccag t 561 61 1446 DNA Ureaplasma urealyticum 61 ttaagtgcca tatcttatag ctcctttttc attaattgca ggtgcttgtg cataaaaata 60 taaatgaaac gcacacatta aatactccaa cgcattaatc gtatgcgtat gctcatgact 120 acgctctttt ttagtatctt ctttaatggt ttttggtaaa acaacgtagc aattttttaa 180 gtccttatat agttttggac acgcattttt actaaatcgc aatttaccac ttgcaagcat 240 gtaattaact aaaacaacac ggtctcaaat agcgtgttta atagcaggtg caaaaacaag 300 ttcagaacca tacatattat attgaaacgc aatgcgttta aatgtagcgt taaatgtttc 360 ataaaaataa cgcaaatgag cattatcaat ataaattaca atcttaacgt ttacttcttg 420 ttgtttttta ataaaccaac gcacaactaa ctcaatttgt tgctcgcttg ttagtggatt 480 aacattgttg ttataaacca tttcatctaa aatctcaatt ccattttctt ttgaaattga 540 accaaataag cacgcagtat ctgatgatga actacttgtt ccatctcccc agtccatacc 600 accaaaaaac tgcattgcat aattatcata ttcgccatat ggttcatgca ttacgcttaa 660 acttcgtgca taaatagcac cttcaacact cccacttaat cccaaactaa ttacacgata 720 tttagaataa tcaatatctt ttcatcattc aaactgctca atttcttgtt gtgatgtaaa 780 tttattcgca cgatatgtac ttcttaaaaa taatttttta tctacaacgc tatattcata 840 atatggcttt tgttggattg agaattcgtt ttctgctaaa tgattattaa aattttcaat 900 atatcagtgt tcacttgttc aaggattaga tgcaaaaata gatacgacct gcgtatcttt 960 ggtaccccta agtgattgct gtgagttttt aactaaatta aaatctaatt gtgacgcttc 1020 ttcaaaaaac gcaaaaacat aacgtgcttg cgttcacaaa cgaaatccaa ccttagcacc 1080 tttgttaatg ttattacgtg tctcatttaa tgcttcaaac attacagttc aaccattaat 1140 aataacagta cgttctgaat ggttaatctt agcaaatttt aataattgct tttggtctaa 1200 aaaatttaaa tagtcgctaa aaattttttt cgcatcagat atattctgac gaaaaacata 1260 tattgcgttt tgctgtttaa tcgcaacaag tgatgacaaa aaatctaatg tcgcaaaagt 1320 cttaccacta cttcgtccac ctaataaatt aatttcatta aatggtattg gcaacttttt 1380 ggctacaaac tcaactaaat cactatagaa accaaaacat tctataaaat ctagttttat 1440 tctcat 1446 62 444 DNA Ureaplasma urealyticum 62 ttatatcaca tttataagtt ttttaatggt taatttgtta ttatcatcaa ctttttcaaa 60 cgttattgtt gtatcttcaa tatctgtact tttttgctca tttgctaact caaaatctag 120 acgtttaaaa tattcttgcg ttctaaactt acgcaatcct tggttgttta tttctttatc 180 atacgatgcg tttcgtccca gcaactcatt taaagccatt ctaaggccgt aattagcctt 240 ggtaatgtat tcataccttt ttttgttaaa ctcgtctctt tgcgtgctta aattaactca 300 cacgccccaa tttatgccta agaattcaag caaagcactc aaattacata aatctaggtt 360 tttagtagtc ataaccaaag tgtaaaagtc attgattttt aactgcagtt cttgtaattg 420 ttttagttcg tttcttttca tcat 444 63 600 DNA Ureaplasma urealyticum 63 ctaaattgct agaaaccaaa caacataagc caaggttcaa taatcaatat tatttttcat 60 tttatctttt aaatcaattt ctaaaccatt aggatttaat aattgattct ttgttaacga 120 tttatggaca acttgtgtta ttccgtcttt tttattaatt tcaatatcaa atgttaatac 180 aggttgatta tcttgaaaag aatttaatat actaaaattt tgtaatttaa tgttaatttt 240 tttattagct ttatcaatta ttgtatttaa ttctgcttgt tgaatatatt ggtttaataa 300 ttcttgttgg tcttcttgtt taaaatcaaa tttaatttca ttattattta aagtaaattt 360 tgatatttta tagttaatat tagatgctaa gccatttaat ttacctgtaa gtattttttt 420 atttgcatca aatactaatt cagtagcact aatagcagaa gcgtcatcat tagcactatc 480 tttaacttct aaaacaaaat cttttttatt agcatctgct aatttaaatt tactaaatgt 540 aacttcaata gtagcagtgc cgttttgaat tttattaatt gttattttat ttgcaatcac 600 64 222 DNA Ureaplasma urealyticum 64 atgttaatta aacccgcgaa acgcagtgaa aaaatttata caattattgc tataaaagat 60 agtgttgtaa ctttaaaaaa tgattatcaa gacgaaaaaa atattcaaat ttacgagttt 120 gatttgcaga atattattcc agaagttggt aaatttatta atctaattaa atacgatcaa 180 caaggttgtt cagtatttga agaatatgat aaaaacattt aa 222 65 876 DNA Ureaplasma urealyticum 65 atggataaaa aagctaaaat ttatacttga tcacacatta ttttaattgt ttttagctta 60 gtttgtttgc attggttttt cattttatca atcacaattc ctaaccaaac tggtttttta 120 attaatcgag ttggtcaatg aataaattca tctagtacat atgcttataa aattgatcct 180 cgatcattat tttatttaaa ttatacttta aactttaata ttgctttaaa tgcaagtggt 240 atagctagta ttgttttatt tatttgttat attttaacat ttatttttaa tctaataatg 300 attggaatta ttagatcttg aaggccaagt ttattacatt taataattgc tatattaatt 360 tgacttgcta ttttatattt atttatcatt attatgatca aaccaaactt taatcagatt 420 attaataata gttattatac atgattaaaa aatgttattt ttaatgatca aactttaaca 480 cttaataaaa aaaatgtgat tttaaatact tatattaatc actatcattt accaataatt 540 aatgatccac aagttgcttt attagatatt agcaaacacc aaattaataa tgaaaattta 600 acatttaatc cttcatacaa ctataatgcc aatctttatt ttacaaaagc aaaattaatt 660 tattgtactt atacaattat tggaataatt tttatcatta gttttattta ttatctaagt 720 gaaattatta aacgatgttt attagttaat gacaattgaa aaattaaaca acacgaacga 780 aaagatggtt taaatataaa aaaaagaaaa aataaacaag aaattgttgc tcctgaccct 840 attttagaag aaatttttaa agaattagat ttataa 876 66 138 DNA Ureaplasma urealyticum 66 ctaacgtcaa taacatcttt taattctttt tcatatttgt tgttctctaa taattaactg 60 aataggcaca aaatatacat tatcatcttt aatatctaag acgttagcac ctgtatcgat 120 taaaattgct gttttcat 138 67 225 DNA Ureaplasma urealyticum 67 atgacttata tgctattaac atctagtgac ttacattgcg ggtcatgttc ttcaaattta 60 tataatgtac ttgaaaagat tggcgcacaa aatattagtg taaatatttt aaattcagaa 120 tttgcttttg aatttgaaga aaataaaatt gctgatcaag atgtaattaa agaaatcaat 180 aaaaatggtt tcaaaacaaa tattttagaa aaatacatat actaa 225 68 267 DNA Ureaplasma urealyticum 68 ttaacagttt ataatgatgt taataaccac attatcatca tttaattgtt ttgacaattc 60 ataatatact aaattacgcg cttcatttgc tacacttaaa acattaacaa catcttcatg 120 taaatcaatt ttaattacaa aataattacg attaaaatct gataatttgt catttatgtc 180 aacactaaaa atcccaggaa cttttaaaat agaggatgta attaaacttt taacaagttg 240 agtatcaaat ttagtttttt ttaacat 267 69 639 DNA Ureaplasma urealyticum 69 ttaatacttt ttcaaatttt ttaaatggtt tttaactttt gttgttttta ataaattttg 60 taaattttca aatttattaa aggccaaatc aataatatct tcataattat cttttgttgc 120 agaatttaaa taaaattttt tcaatacatt tttatcagca aaaagtaata aactatgata 180 tttttgcttt ttatttcttg aaatttcaaa tagtaaaatt tgtggattgg aattattaat 240 caattttttt attgtattat atattaattt atttcacaat tcgtctttaa aatcgttttt 300 tgttaacgta aaattaaact ggttacttaa atatctgctt aaattatttt ttttagtaac 360 atagatttga aataaattaa tataaatatc cttataaata aaattttctt ttaataagtc 420 atttttattg atcaaaattt catctcagtt ttttcaacga cgcatttttg aaggtaaata 480 agcattttga ccagataaat aatatatata attatcattt tcaaataaaa taataggaaa 540 acctccaatc atgttttcaa aaggatcact aacaatataa tttaaatcac tatttcttat 600 taaaatctct ttatacatac tttttcagtt gatattcat 639 70 1287 DNA Ureaplasma urealyticum 70 atgccacgaa taaatacgca agtttttaat gaaaataatg ataaaaatag aattaaaagt 60 aataacaata aaatttgtga tgatattgaa tacactcgct tattagaaac gaaagaatat 120 aatgctggtt tttctcctaa taatgattca caagatatct taattaaaaa acaagacaat 180 attttaaagt taaaaccaac tctaaatttt gatgatagtg atcaattaat ttcaattgtt 240 cctactaaaa attatgaaaa tttaagatta aaagaaattg aaatcgataa aaaaaacact 300 gttgattatc aattaaaaaa agaaataata gatcaggact taacagatga taatcattta 360 tctataagtc aaaaatccaa tggttttgct ttaaaaacta aacaatttat tcctcaaaat 420 atttcagaat ttatttatca taatgaagac gatccaaaaa catacggaag tgaaaataat 480 ttaactttta gtcaactaga agaaaaagtt aatcaaaaaa atacacctga tttttattta 540 aaagaaattc atgcagttcg taacaaaatt atcatttgaa ctattttatt agcaattggc 600 gtaggattaa tattttattt gatttatgaa gttattatta atcattttaa tccatggatt 660 tttttaccaa ttagtattta ttgtgtcttg atgattttct ttttagcttt atcatgtagt 720 aattttataa attttaaaaa agaaatggat tatcaaaaaa accattttga ttgtacaaaa 780 gcaacaaatt ttattgtagg tatatatcgt aaattaatag tagtacatat taatgtaaac 840 tgaatcacag cttatattta tcttactagt ctttttatga tatttggtgt ttttgttgtc 900 agttatttta tgaatttata ttataatgca gctataggaa gtcgttttgg tgatttgatt 960 ataaaaattc ctgttgttat taataatcat ctttcacaaa aaattagttt taacaaaaat 1020 ccattatggg caatgattgg attaggtgct attttaggat taacatttat tattcattta 1080 tggttggttt ttaatgctca tcatcgtatt aatcgtattc atagttatta tgttaatgaa 1140 atcattacta gtgaagaaat aatttcatta aaaaaacaag caaatcgtcg tggtctagtc 1200 atatttttag tgttaactgt tattttaggt ttaatttttt atttgatgta tactatttta 1260 aaaagaaaat acactatcaa aaaataa 1287 71 1149 DNA Ureaplasma urealyticum 71 atgaagaaga atcataaaaa atgattatta atgacaacgc caattttatt aattggcgga 60 ttatcaacat tggcattaac aagttgtaaa gacggaaaaa aatctaatcc aaaaccagat 120 aaaccatcaa ctatagaaga atataaatta agtttatcaa gtgttgaaac tggttttaat 180 gaagctaaat taatttttga taataatgat agttttaaaa cattagataa ttttaaagtt 240 attttaaaaa atactcaaaa cactaatgaa gttattgaag caagtaattt atctgcaaca 300 attgaaaatc aaaaattagt tttaaaacta aataatttac aagacggtca aacatataaa 360 attaacaaaa ttttatatca aacaaataaa gaagttattt taagtaataa tcaagtattt 420 actacaaaaa ctaaacctaa aattgaatat gaagtacaag aaaaaatttt gaaacttgat 480 gataaaacat attatgttgt tctaaaagtt aaagaccctc aaaatttaaa tgaaccaaca 540 aaagaaattt taaaatctgt aacttttact tcaaaaatct caaatgttgc aaatcttaaa 600 aatgcaatat tagaaaatca aagaccttac gttaaagaag attattcaga aattcaaatt 660 aaattaccaa gagtacctgt aattagtgaa aaaatagaaa tcactgcaaa caattcctta 720 tttaaatcat tcacaattac tgttggtgaa aaacatatta aaaatgtgga aaaaatcatc 780 gatatcacta aaaaagtttt tggtaatcaa gaattaaaat ctattagtat tacaaaacaa 840 aatagtagca gtgccaatat aacattaagt ttaaaattaa atggtaattc aattattgtt 900 ggtgctaaca aattaattaa taaaaaagac aaagcaataa aatttagctt ctttgttaaa 960 aataaagcaa caaatacagt taaagaattt aatttcaatg aaaaatcaaa acctattgga 1020 agctatcaat tcacattaaa tggattagat gctaatagtg attttgtaat tgaagatatt 1080 agatatgatg ataaatcaat caaaattaca gaagagcttt tagctagctt aagtttttca 1140 acaaaataa 1149 72 318 DNA Ureaplasma urealyticum 72 atgaaaaaat gacaaaaaat tttaacaatt gcactaccaa ctagtttatt agttgctatt 60 ccaattgttg ttgcttcatg ttctactaag agtgaagcac aaaaagaatt tgaaaaaact 120 tataaagaat atttaagttg attagacaaa ttagcttcaa aaatgccagc acttaaagaa 180 gcttttagta ctttgaaaga agaaattaat aaacaaatca ataagagtga aaaattatct 240 gatgaagcgt ataaagcatt aacagcttca ttaaaagttt caattgatgg aatgaaaaaa 300 acattaggac aaaattaa 318 73 1866 DNA Ureaplasma urealyticum 73 atgaataaac aaaaaagaaa aatctcagta ttaacttcaa tatcattatt tttaattatt 60 agtttaagta ttgggttagg tttgggatta ataaaaaata atgaaaattc catcacttct 120 aaagttcaaa aaagtagcaa tttttttatt aatgatttat caaaacaatt gtttttagat 180 gtttttaatc aagataaatt agaattaaat gcttatatgt atgatcaaaa taatgtatca 240 gatcaacaat tattagattt aaaatttgct ttaacattat taaatcctaa cagattagat 300 attaatgatg acgatacaat tgccattatg aaaaataatg ctaaaaaaat tatttttcaa 360 agtttatcta ataattgata ctgattattt accaatttaa agagtttaga attttcttac 420 actccttata aacctaattt ttatgccccc tatataaatg aaaaacaaga ttttactaaa 480 tcatcaattt ttgacaaagt tattaatatt aataaaccct taacaaatta cataaaaatt 540 aagcaaaaat tattcgataa agaaaattat cgtagtgttg atgtttatta tttgcaattt 600 ggtgatcact taatcttacg tttattaaaa tttaataaaa aaaatcattt tgatgttcga 660 tttgatacag atctttttca attcaataaa ccaattataa atttggaatt aatagcaaaa 720 gaaatgcaaa caagtattga ttatcatcga gaagataatt ttaaaaaaga tattttagat 780 tataaaaaaa attatgaaga ttatttatat tatgatgaaa agcttaactc aagtatttat 840 caacagggat tagataaaat aaataaagaa tattatgaag tcaataattt taattttttt 900 aatactaaaa aaccactttt tcaaaaattt agttatcaaa tgtttttaga attaaaagat 960 aagttgggtt ttaaacgtta tgttttaaga aatattgatc aaaaagaagt tagagcacgt 1020 gatcatttta atgacaatga aaaaaaacaa caaaataaga attattttag atcttttgat 1080 aaagaattga attattttca aaaatatatt gatcataatt tagatattaa tattaataaa 1140 atttcaaagg aagcatatat tacacaaaaa ataattaaaa atcttttatt agatgctttc 1200 aataataatg atgttcaaat tacaaaatat ctaattcaac aaaatgataa ggaataccaa 1260 aataaattaa ttaaacaatt aatagaattt agtaattatt ttaaaaacca aaaaacacca 1320 agagattcta atgaatataa gcaaaaatta aatgattatg aaaaaatatt ttcacaaaat 1380 tggtatttta ttttaatgaa tttaaagcac tttgaattaa gttttaataa ttgatttact 1440 ttaccaaaac aaataaatcc tattactaaa gagatgttag gaccaagtga aaaatattta 1500 aaaaggttaa aaaaacttaa accatatgag gattattatt tcattaataa ttatttagaa 1560 aaaaaacaag aaggagatac ttcaatgttg attggttcat ttaaggattt atatattaca 1620 aaaaatcaat ctatttttaa tattaagatc gatttttcaa gtagtgaaaa cagattaagt 1680 ttaaatcctt tgatttattt ttttcctaaa actaaaaata aattatcagt tgatttaatc 1740 acatcaattt ttcatcaagc tatatttcac caaaataaag aatactatca attgtttgaa 1800 actgatatga ttgataaata tgaatatggt atcccagccc aaatgttact tttatgaagg 1860 gaatag 1866 74 1296 DNA Ureaplasma urealyticum 74 atgtttattt tttttaaaaa aaatcatcta ctaaaattaa gtttattttt tattcctcta 60 acattaattt caatccttat cacctcatgt agcacatcaa atttaaaaaa acaacagata 120 ttaacaaata atgaaattag tttttttatg gataaatccc aaaattgtta tgttggttta 180 attgttgatc agacattaaa aaatgataaa aaaactattt ttaacgttag tttaattgat 240 gaaaaaaata cgaagttaaa tttattagtt aaagattatc aaattaaaga taacaaaatt 300 ttaattagat taccgcgttt aataaaactt aatgatcatt taattattac aagcaataat 360 gcttcattca tacctattag aaaaataatt aatattgata atttaattga tttgaatata 420 atcagaacaa ataatcaaac acaagattct tgaatagctt ttttaaataa caaagtgatt 480 aataatcttt taataactat ttttcctaat aaaaaagacc gtgatgaata tattaaatca 540 caacaagaaa ttaaaataga atatgctcat gaaatagcga attgattaaa ttattataac 600 acagtgcaaa atgatgctaa taaagcagca gtatttaatg aaaatacagc tagaagtaaa 660 cttaataaca atctttttaa taatgtatca ttaagcaatc catttgctta tgaacaagca 720 cgtaagtttc acaatacatt atttaataaa aattgattgt gatttttatt taatttaaaa 780 agacaaattt tcatgttata tcctgatgat aatttatttc aagaatcgag cgaggaaaca 840 gcagaaggat taaaagattc aaaaatcaat aatcgtagtt ctttttatcg tgctcaatcg 900 aatgaattta ttgatgggtt atatgttgta gaaagttcta atttaaataa aaaaccagaa 960 gaattagatg aatatactga ttttagtaaa acagctaaat ttactctgtt gaataatgaa 1020 ggttttgttt ttacaatctc cattgaagaa aattatgata aaaccaaaaa actaatttcg 1080 cgtaaagtta gtttgttgcc atgaattaaa actttaccaa gattaatgtt taatgatcat 1140 gtaataaaac aagaatttaa tttagctaat tatactgaaa attcatacga ttacaatgct 1200 gttaattttc attcacctct tgaaattaaa gtttatgaag atcaatttgg cggaaaagca 1260 attcgttttt catttgttga tattgatcct aattaa 1296 75 408 DNA Ureaplasma urealyticum 75 atgaacaatt acatacagca agttattgat tatgttaatg ataaaaccta taaaaataag 60 acatatttta taaagaaata tgcatttgct tttttgactt cattaataat ttttattttt 120 ttattagtat ttggtttatc aaattatttt aatcctttgg ttagtttagt tggtgttgta 180 ttaattttta gtgttttagt tgtcttttgt attcatataa aaattatcaa taattatagt 240 ttaaatttat taaaatgact acgtaatcaa aaagaattat cttataagta tattattaat 300 attcttgatt ttattttaaa taaacaatta tatttaaact taacaattat agaagtccaa 360 caaatttgca tagatttgga agaatttaaa aaaacaaatg tcatttaa 408 76 1785 DNA Ureaplasma urealyticum 76 ttactctaaa ggattagtta acgcgtattt tttacatatt tcaccaattg ttctctctat 60 tctaaaaaac aatcttgctg tatcatattc attttttaaa tgattaggaa cttgttttgt 120 taatataaac atttcatcac tatttttaat tttttcacct ttatcatctg ttttatagtc 180 agaataataa taaaaattat ctcttttttg attaaaaggt tcatagatat tagtgtaatg 240 atatttaaaa ttataaagtt cttctaattt tgaaacatcg tttgctgaat cactttttga 300 tttaatttga tcaataatag gtttaattat cttttcttta taatattgaa aaacatctgg 360 taattgattt aaatagtaat tagatcaata cattaattca ccaaattctt cttggggata 420 aaaaccataa ccaacggctt taatatatgg aacaatttgc tcaacatcat ctttgacaac 480 gctatcataa aatctagaaa gtttttgatt agcattacgt gcttttttct caatttcgtt 540 tgttaaatct tttaattttt taattaagag gtagtattta cctttttttg aaagagaatt 600 aggatctatt gatggttgtc aattatctaa cattgaagtt ttggacttaa tagtaaaaaa 660 tagacccgaa aaattggctg cgtctaaact atctctaata agtgcttgac catataattt 720 tcatttttct attaattgtt ttaattctag agatttagtg tttataaatt tttgttttgc 780 taaatcttca atttttaatg ctaatccata tcaaatagca acattagtat tatccattaa 840 agtttgatat ataaactttt tacctaaaat atcttctttt catgtatctc aaaaatcttg 900 attatttttg tggccatttt gtttaatata ttgtgaaact tttttatgtt cttggatttc 960 tcttttaata ttatcgattt tattttcaat taattttctg tttaatatac tctgtagtac 1020 tgaagaaata ttttcatgaa gttgattagc ttcatgaaat aattccataa tttctctatt 1080 gtataactta taatattctt caccattatc aattttttca aaataattat gttttaaatt 1140 tttaacatca gatttaatat ttttgatttt attagcttca tcattaattg tttttttata 1200 aagaccatcg tatgattcaa tcattttttt atatcttaat ttgatatcat caatattttc 1260 attatcagga atttgattat aattagttaa aatttcttca atattatttt tgatatgatc 1320 gatatcatga ataattttgt ttttattttt aaaatttaaa aaatcggctt gtcttttttt 1380 tattaattta acaaagttat caattttaat taatcatgat tcatattctt gtgttttttc 1440 ttttaaaaga taattaaaat cttttattaa tttatataat tcataataag taaatgctaa 1500 taattcattc tcactatttt catttaaatt taaattcacc aagtaattaa tataattatt 1560 gattatatct gctttattaa gaagataatt gtatttatga ttatttttaa gaacaaaatc 1620 aactttagaa ctagcttctt ctttaatttt caaataaaga ttaaagaaat ttttattgtc 1680 ttctttttta atttttgtta atgagcaact caaaattata ggaattggtg taactataac 1740 tcctataaat gataataaaa aagttctttt aaaatttatt ttcat 1785 77 672 DNA Ureaplasma urealyticum 77 atgatcaata aaaacaaaaa atttcatttt cagtatttta aaaaagataa cgatcaatca 60 atttctacta aagaaacatt aaaaagatat tttaatttta ggtctcaaag tgtaaaattg 120 attattttta atttagtttt aacagcattt tttcttgcat tatttttaat tggtcgtttt 180 ttaactaaaa atttagattt tttaaatggt tttagttgac aattgcaaat gggaattttt 240 gttttagcaa tcgtttgtat tcccaatttt tattataaat taatgtatta tattattgcg 300 ccgttagtga tgttagcaat tggttttagt gctgagccct tctttggata tttaatgcca 360 cattatggtt ttggtttaat tttatttacg gatgtcattt taattattgt taaaaagtca 420 tgtcagtcaa ttaaaaagca aatattttta tcctatttat taatttttag cttttcaatc 480 attggttatt ttattgtttg aatgggctat agtattcaag gaacactttt ttacaatact 540 gcttttattc cttctatgat ttataattct ttggtaactt ttggttcaat ggcaattaat 600 tttgtattat atataatttc aattcccgct attgttgcct taaaaaacaa atatttatgt 660 aaattagttt aa 672 78 1374 DNA Ureaplasma urealyticum 78 atgtttatgt ttgatcaaat ctttaaaaaa aggaaacgtc atttaaactt tcaaattttt 60 attttctttt ttgttttaat attaattact tttttgattt tatgaattat ttcaggtaat 120 gttcaaacaa ttattgattt tattaaaaaa aagatttatg atgctagtcc acaattaaaa 180 tatttaacaa atattcagat caaacctttt aaaaatttag aagaaatttt tgattttatt 240 attaaaaata agaatttgat taaagattta caaaacgaac ctgaaatttt agatgttatt 300 aaaaacaatc cacagatctt aaaaacactt aatgataacc gcgaattttt aaaacaaatt 360 gttgaatata agccatttgc tgaaattctt agcaagcaac ctgaaatttt aaaatttgtt 420 caaaataata aagaattaat taaacagata caaaatttac ctgaattatt agatttaatt 480 aaaaaacacc aaaatttaat tgatcactta aaaactaacg aaaaatatat agaagttatt 540 aaagctaatc ctcaaatgtt aaaagatctc tatcatgtag atgataattt atttaatatt 600 ataaagacaa gcttagaaaa tgataaagaa aataatattt taatgttggc tattaaatat 660 tcagtattaa ttaataattt tactaagaat ttaactttac aagaatgaaa gcaaataata 720 gaattttata aaacagttga tttaaataaa tttatagttg atgataattt gtttaatatt 780 attaaaaata ataatcaatt atttgaagtt tttttaaata attatgacta cataaaaaat 840 cttgaggaca atcaaaaaat tattgatatt attcaacaaa atcctgattt aattgatgat 900 tttaaaaaga ttgattttga tcttttaaca caaaaaagga attttgttcg tgcactaatt 960 aaaataattg attataaaca acccaaagaa attcaattcc ttaacaaaaa agttttttta 1020 gatttcttta aaaataaatc tgaaattacc aatgctttaa acatcacatc tttaattgga 1080 tttgtattgt ttatagtaat ttatacaatt tttatttttg catcttttat ttctcatatt 1140 ctaatgttaa aacaaattaa agattttaat aaaattttta aagaagctaa attaaaaaaa 1200 atatatctta taagcacttt attattacaa tttttatttt taattttatt cattattaat 1260 tttatagtat taattattct agttgtagat tataataaat tgaaagcaat agttttaaat 1320 agtggtataa aaagaaaagt ggaggatagt gatgcaagat tgcatttttt gtaa 1374 79 756 DNA Ureaplasma urealyticum 79 atggaacaaa ttagaaattt aattgattta caaatcaaac taaaaccaat ccaaaaagca 60 ttttatgatg cgtgatcaaa aacatttatt aatggaattg ataataataa agaaactcat 120 gaacaaaaca aaaaaattat tttagaaatt tatatgattt taaaagtttt tttaaacaaa 180 aaccgagata ttatttctaa aattccatta aatcaagtta aaaaaatagc taatgacatt 240 ttagaaaaag aaattatttt agaacagcct ttagttgatt attattacca aagttcatct 300 tgttttattt taatacctta tttgattcaa attctttatc aatcttatca ccttaataaa 360 ccaatttata aaataatgtg taaatttatt attagaaata atttagcatt atttaaagaa 420 tgagatttaa ttgaacgtca aacattggaa attattaaat taaaaacaaa tttaattgaa 480 gataacaata aggcaatcaa tttatttagt tgtgaacaac gagaattaca acacaatcgt 540 tttgtaaaat tatttaataa ttttatttta gtgtattgaa ctaaacgaga agttaaatac 600 atagaggcaa ttcgtttttt gatgtatttt atttgaattc ctatcatttt tattgtttta 660 ttaattttga ttttaggttt atattttggt ttaagtaata gtgaatcctt aaaaagttca 720 acacaattct tactagattt gtttattatt aattaa 756 80 546 DNA Ureaplasma urealyticum 80 atgggattaa aaaaagaaaa aaaagatcgt tcaacgattc aattattatt tggaacaatt 60 aaaaaacgca aaattgcgaa ctatttaatt attgcttttg cctttttaac atttgcctta 120 gcaattatag gaagttttga agctattgca tcaaaatatg ctattggcat tggatcaggg 180 ctttcattat ttattacgat tgcttttagt gtttgacgaa ttttaatgat tcatttagaa 240 aaagaatgaa ataaaagtga aattatttga caatccgtta tgggcgcaat tttagtatta 300 tcaattattt tttgaatatg agcaacaact acaacaacta tacaatattc atcactaaaa 360 gaacatcttt tattgttaaa acaacaagat tcacgcgcta attttgttgt tttaacacaa 420 gcaacagtgg atgaatttgg agttgcttta aaaggcgggt tatgagcttg agttattaca 480 agttgtattt atatttttat caatactttt aataatatgt ttatgaaaga aaaaaattca 540 aaataa 546 81 606 DNA Ureaplasma urealyticum 81 atgattaata aaaagataaa gattaaccca aatataacat attttaaaca aaaaatttct 60 aattatcatg agcatttgtt agtttgaaat gatttatatg ataaattaat ttcattgact 120 aataatatta ttgttgataa aaataacaaa aatatttatc atcaaaacga caaacaaatt 180 tttgatttta ctttatgttt atctggtctt ttgtctaaaa ctttaggttt aaatcataaa 240 tcatcttcgc tttatttaac aaatgatgat gaagtagcgc atcgttttaa gattaaagtt 300 ttgcataatt attttaattt atataatatt gaagaatttt ttacgtttat ggataatcaa 360 attcctttag aaaatgcaaa aaatattgca cgtttaagtt taatttatga tttaaaacaa 420 catgaaaata ttttaaaaac tatatcgaat gaaggtttag aaaatattga tttagaattt 480 gctttcatta attttttaag agcaaaaatc tctattaatt ttgcctatag ttatgatatt 540 tctgaagtaa ttttattgtt gcgaacaggg ctagatttac atttttttag aaaatgagca 600 ttttag 606 82 156 DNA Ureaplasma urealyticum 82 atgaccgttg catatcataa tttagatatt aatgacccta aaaatgttct tttagcaacg 60 caaaaattct ttaatcatat taatgaaata attattgatt atggtttaga taaacgtgat 120 caatgaatta aaaaaattat tccttttgaa gaataa 156 83 591 DNA Ureaplasma urealyticum 83 ttaatcatta atattattac aagattgata tttctctaat tttttaataa cattatcttt 60 taaaacgtta gttaaaaata ccgccatatc atgaattgat tctttagcac cattttttaa 120 ccattgcatt ctaatattac aaaaaaatcc tgttaaataa ttaattaaat atttatcaat 180 tgaattattt gacatattac ctatagcata aaaaccactt tcagtggtta aatcaacaat 240 taatccacta aaattatttt tatctaagat tagaaaatat tctttgaatt ctaaactaat 300 ttgtaatgaa atttcataaa atttagtaaa accaacttca tcaaaattga tatttaggtt 360 attatttatt aatttactta caactttcca attataaata tttttaataa aataattaat 420 aatcgaaatt ttatcactaa aattacgata atatgaaggt cgcgaaacat ctgcaacctc 480 aataatttgt gaaattttaa ttttgttaaa tgaattggtt ttcaacaaat taaataaagc 540 tgaaacaatt tttaatttaa cttttgaaat tttaattttt tctactgcca t 591 84 4344 DNA Ureaplasma urealyticum 84 atgtataatg atcttttaga tagtttattt acaaaattaa gcgataaatc tattttaaat 60 aagttattaa atgatgattt tttatcaatt ggaagtattt taaaagaaat ttttaatata 120 aatcaaccat cacaactaat aaaagttatt gatattttta gtatcaaaga cattactgcc 180 caagattatg taaatgtttt gaatgttatc tttaatgata ttggttttaa taatcaacaa 240 acaaaacaaa atattaccaa tgatcaaaaa tacgatatta atatttactt tgaatattta 300 aaagctttag ttgaacataa ttttagtgag ttaactaaaa caaaattaaa agaaatcgtc 360 aaattattcg ttaaagatgt aatgaatgat gaccatcata accatttatg aaaaaaaatg 420 acatcgttta ttagtcataa attaagtgat ttattaatta aaaaaattca agtattaact 480 ccacagaaaa atgaatatca acaattagtt aacaatttat taaatggtat tgattttaaa 540 aatgttgtcc aaaatttaat tgttgaaggc tttgcaaaaa taattgatca tcaacaacaa 600 ttaaagaact cacaaaattt tggagattta attcaaaaag ttatcaatat agatgatgta 660 tgaattaaaa aacaattaaa acaactccta agtgcaatta caaaagacat aaatttaaca 720 aaagctacat caactactat tattaattcg tatttaaatt attttgaaat taaaaatcta 780 acagaagaag ataaaagaaa tttaattaat atctttgaca aaattttaaa gcaaattcct 840 aatttattat atttacaaaa tattgttgat caatcagtag attttttaaa agtaaatatt 900 gaagcattaa ttaatcatca accacttaaa aacacaacat gaaacgattt tattaacaaa 960 aatgttacag atattagtgc tttaagtaac ttattagaaa tttttgaaac taatgaaatt 1020 acaaataatg aatgaaacca attaattacg attttaatta atcatgcacc tattgataaa 1080 attgaagaaa tcattagaaa cataacatca aattcaataa ttaacaataa agcacaaaaa 1140 caagatatta aaaaacaaat tgataaaatt tatctactta ttaaaaaagt tttacaaaca 1200 caaaccttaa ataaaagcca tgccaagact agtgttgtaa aaattaacga aacaattaaa 1260 acattaattg attctttatt tgctaatcaa gaaattaaaa ctttaattag taatacatta 1320 tcaaattgga ttttcagttc gaatttagca aaaattttaa atgttgacga agatcaaaaa 1380 aatagtttaa ttaaaccagt agttgaattt attattagta gtaatgattt aaaaacaatt 1440 ttaaaaacca taacaaatag ctttatttta catgctagtg aattagcgaa cacaaattct 1500 tttgaagaat taattgttaa acttattagt tttgagcaaa ctaatttaaa aagtaattta 1560 aataatttta ttcaaaaaat acttcaaaac gataaaattg atgaattgtt agcgcgtgta 1620 atatttaaac aaatttctcc acaaaaaaaa tatgatcaaa ttcagcaaat aaataaagac 1680 aaagtggtca cttttattaa gaagcttggt gacaatctga caaaatttga tttatataat 1740 aaattactcg ataatttatt tagttcaatt acaaatcaaa caaatttaac aaaattattg 1800 agtgaacagc aagatagtgt aattaatttt attaaaacga tttttgattt tagtgatcct 1860 aaacaaatta tttcactaat tgatgtatta aaagtcaacg agattacaag taatgattat 1920 attgaagtta ttaaatcaat tttagatgaa attgatttta atcatttctt taatcaagct 1980 gtcaaaaaca gtaatctttc aaattatcca ttgaataaac atgaaaatga taatgatagt 2040 aaattagata taaataagta ctatatttat gtaaaaacat tatttgcgca tgaaatggat 2100 tctacatcaa aagaaaaatt aaaaacaatt attgatgaac taacaaaaaa aattgttgaa 2160 aataataata agggcttgtt gtacaatttg ggcaatggat taggtgaaaa actaagtaat 2220 ttaattatta atacattccc tgggttaact aatttaaaac aaaactataa aacactagta 2280 caaaaagtat ttactaatca aaacttgttt gagcaagttc aaaatttgat cacttatgca 2340 atcaatagtt tgattgatca taaaaatgaa tatcaaaatt gtaaaacttt tggtgaatta 2400 ttaacaactt acattaataa gaatcaaaca caaattattg ataaattaaa agaagcaatt 2460 aataaaataa tcagtggttc atcttcatta attgatgaaa tttcaacatc atttgctaat 2520 acaattaaaa catattttaa attagaaaat ttaacagtag aagatatcaa taaactaaag 2580 tcatttatta attttgttat caaaaatatt ttcaatcttg aatatgttaa tgatggttta 2640 gttaaattaa ttacgacttt aagttcaaac gccataaaaa ttgttgatca aaacactaat 2700 tttgtaactg ttatgcaaaa tgatgttatt tcatatttaa catctccgca acaaattgca 2760 aaattacttc aaattgttga tttggataaa aatgatgaca ttttaaattt cttaaaagtt 2820 attttatctc atttgcctca aaacgcatat actattttat ttggtaataa aattaatctt 2880 ataacaaaga acacaaatca aaaaactaat agaagtgtaa ttcaaaaata tacaatatta 2940 gattatgtaa aaactatttt aaattcttct tacttaaaaa aacaagatac aattgtaaaa 3000 attaaacata tttttaaaga tcttttagta actatatcta aatcatcaca attaaataat 3060 tatattggtg agttgattag taatactttc gcacaaaaac tttcaaatct tagtggtgtg 3120 gataaacaat atagtgaatc atttttaaaa gaatcatata aatttattat aagtgatgaa 3180 aaattaatca agattattga tgaagtagtt aatgatttag ttgatcataa agatgaatat 3240 ttaaaagaaa ttacaaacaa taatcaacca tcaattaata ttattttaaa tatgttaatt 3300 aaacgaaatg ttgatcaaca aaaagttgat tttgtacctt ttataaaacg ttatttagtt 3360 attgattctt caacacaatt tatggctcaa taccttttta aaactttaaa attagaaaat 3420 actaatgatc aagatgtaaa aattgttcaa acatttgtaa aagaattaat taatcaaatt 3480 gatcaattag attttgtaaa tttattcatt gataaaatat ttactttaat aaaagaaaat 3540 ggacttgatt tatttacaaa agaagagggt ataaaaaaag taaatgaagc tatgaaaacg 3600 tttggtttaa ctgaaacaac taatttatta aaaattgcaa aacttgtcga accaaataaa 3660 attaaacccc aaaccatagg tgatctaatt aatttagtat ttgaaaaatc accattagct 3720 gaagatttcg aaagtataac acaagataaa aatcctttat attatggttt aaaaaatctt 3780 aaagaagata gtttaaatgc tgttttattt gctagtggca aaaagaaaat aggagaagca 3840 gcaaaagtta gtgaaattaa tatgttagat gctatccaac atttaattaa taaattatga 3900 tcagctcgtg cagaatacgc taaaaatcat cctaatttag aatatgaaca agataatcca 3960 tatatgcgtt cgctaattca tttaggaatt gtgatgcaat gatatgttca tgaaacatat 4020 tttagaaatg tttcaggtgg gctatgatgg actggttctg attcattatc gggtgaagga 4080 cgtgtctatt tattgctaaa agcagatatg ggatctgaaa gtgaaaaacg agtacgctca 4140 atgattatgg ggaatcgtgg tgcaatgctt tgaaatacac caaaagagtg gaattataat 4200 aaaaatgatt ttttatatat gattacatat tgaaaatgaa gaacaaattc acgttttaac 4260 gattctaaag agaaaaataa agcaacttat attttcaaag ctttaaaacg cggttatggt 4320 gaaaaagtta aaacaatgaa ataa 4344 85 606 DNA Ureaplasma urealyticum 85 atgattcaaa aagcaaaatt ttatgctgga tatatttctc gtctgcgttt tattcaaaaa 60 ttaagatatg aaattcaaaa cgaaaaaaaa acattgaata aaataattaa agttgtgaat 120 gatgctgata ttagtacctt atatgatttt aaagataaaa atctaactat ttatacgaaa 180 acattttatt tccataatta tcaatttgtc aatgctaata aaaaaaatta ttttatttct 240 aaaaaaacta ttaaatctgt tattacagaa aatttattag atataggatt tacttgaaca 300 attatttata atgatcaaac aaaaacttat atcaggccaa ctgattttat gaccaaaaat 360 tttattgatt ataaaaaaaa tgaaaataaa attgctactc gttcgaaaat tttatatgat 420 atgattgtta aaaatgaatc attaaatatt aatcatagtg aatatgaatc tttattagtc 480 aataatgaat gaaaaagata ttatgaaaat atgattaata tatttttata tcaatattat 540 aatgaaggta taaaaaacga tattgatttt ttaaatcatt ttttattaaa agatgcacta 600 aaatag 606 86 741 DNA Ureaplasma urealyticum 86 atgagtaatt acgaattacg aagaagaatt ataatgtcaa atattgatgt aaaaactaat 60 ttttgaaaat taaatcaaaa gaataaaaag attttatttc gtgtgcttgg atattctagt 120 ttatcagtta ctataataac acctttaatt tataagatat catataataa acaatactca 180 tttattacta aaagtatacg agaattaaaa acaattgata ctaattttgt ttcatcttat 240 tcagattttt atattcttca gaaatcaagt atatctaatg acttgtataa ttataatttg 300 attaacaatt atcatgattt tgaaaaatta ataaaaaacg atttgaattt tgataaatat 360 aatagtgctt tgatttatga aaaaataaag gttagtttat tagagaaata taatgaaaat 420 tttttcaaaa ataacgatct gttatatgtt tcttataatt cattagactc aaaatatttt 480 ttaacttcaa ttttgagttt tgattacaat aatttatatt taccattttt aaacactaaa 540 tcgattttta atgatgagta tgataataaa aatttttata cagattcagc tctaagtact 600 actaaaacag aagttaaatt ttttagtatt aataaaaaat ataacataaa acttaaacaa 660 attaaaattt atagtattga aacggcaaag gatttatttc tatacaaaaa ctatgttcga 720 aagaataata aacctattta a 741 87 303 DNA Ureaplasma urealyticum 87 atgcagtaca ttaccattaa taatacaaaa tcagggaaga ttttaatctc aaaatcaaat 60 attaaaaagt ttattgaaca aaaatttaat ttgattgtta ataaaaaatt tgtaattaag 120 aatatcgata ttgttcagta tgatgaatcc cttgttgata tatctattat tatttcatta 180 tttgatattc atcaaaaagt tgatcttgat gaagtaagag atgtacaaaa tcatttagct 240 tcttttattt attcaaattt aggcgttgat actaaaagtg taaatatagg gattgattta 300 taa 303 88 363 DNA Ureaplasma urealyticum 88 atgaagcaac gattaataaa ttatattatt gttttaattg gtattttatg tattgttagt 60 cttgtcgttg gttttgccgt ttgatttagc cctaataaaa attttgatac gttaactcaa 120 aacaaaattg atggtaatga agttaaaaga ttatataacc caaacaatgg cattttttta 180 gaacaattag aagggtttag taaatataat attgctggtt atgtggttcc aattgttttt 240 gttattttat catttatttt attattttta tattattttt taaataaaaa atcacgatct 300 aaagctgatt ttcctattag tgaaaaattt attatcacac ttcaattacc actctttatt 360 tag 363 89 501 DNA Ureaplasma urealyticum 89 ttgcaagaag gagattttta tgcgacagat agagaccctt ttttaacata ttgaaaagaa 60 ttaaaaccaa gtttttatgc aaaaaaaagt gtttatattg catttttaac tattataatt 120 gcttttgctg ttagcatcat tggttttgta aattattttt cattaaaaat tgccttagaa 180 caaacacaaa aagccacttt agaagttcaa aaacaaaaag aagaacaaaa aaatcaatta 240 tcaaatggtg tatattttga tcaggattta aatttattaa atgagtatga taaattagtt 300 ttatatcaaa aaaataattt atcaagtata gtctttttag cgattaatga ccaagaacaa 360 attttgatgc aaaaagatca ggttgtagtt aattctctaa atattgaaca aaaagttaaa 420 tatcgtgaac aagcaacacg aattgttttt gagaaacaag ctgaacataa tgatcatcta 480 gtaacttctg gaaatttcta a 501 90 561 DNA Ureaplasma urealyticum 90 atgtttgaac aagtattttt tttagcatcc attaacgaca aaaagattat tagatgatta 60 tatgaacgtt atcataaaat ttttttaaaa tatattaatg agcaattgaa ttttaaattt 120 tatactttag agattgaagc aaatgattta aaaactatta tttatgaaat atttttaaaa 180 atatttcaag taactagaat taaaagttta aatcaattta taggatttgt taaacggcaa 240 atttattttt atttagtata tttattacgt aaatctttat ctaataaaaa tttagttaat 300 catttaaata ataataattt tgaaaattat gaattaatta gtaccaattc agatgaagtt 360 ggtgctgaat taaacaacag atttttaatt tatgaatttt taagaagtat tcagaaagaa 420 aatttatttt tatatcattt tactatttta attattaaag gatataatac aaaggaaatt 480 agtgaaattt taaaaattaa ttctgcaaaa atttattatt ataaagcact tttaaaaaaa 540 tatataaaaa aattattata a 561 91 381 DNA Ureaplasma urealyticum 91 atgaaaaatt tttcaaaaaa tagaaatatt aataatttta aaaacccttt aagagttatt 60 gaaggaattg ttcgtgaaat taaaaataat gaacttcaaa ttgattttgt taatagtcat 120 aaaaaaggag tttgtaagtt tattaatttg acagattatc attgaaatac aatttcttcg 180 cgttttttaa ttaacagtaa acacttattt ttagtttcaa aatttgaccc aattcgtcat 240 gtttattgat taaattataa aattattcat cctattgaaa ttaaaaacaa acgtcgttct 300 taccccactt tatctcatga tagaaattta cggatctttt taaataatct attagaaaaa 360 gaaaatgaat taaaaaacta a 381 92 252 DNA Ureaplasma urealyticum 92 atggcaatga aagttaatga aagaacttgt gtttttagta aagaaaaata tcctaaagat 60 catttagttc gctttgttat tattaacggt gagttaattt ttagtttgaa ttatcatcgt 120 gggtattatt taatgattca aaagaataca aacattcaaa aggtgtgtca atttctaaaa 180 aaacgtttta tgattaaaaa cgaagaacaa gtttatcgga ttttagagca attaattcaa 240 tcattaattt aa 252 93 471 DNA Ureaplasma urealyticum 93 atgctaatca tattgatgaa ttatttaaaa aaattaaaca acaagaaaat taattatcca 60 atgttaaaaa aacaaaataa aaataaagaa caacactgat tagaaaaaca tttacgacaa 120 aaaacaggtt tgattatttc ttgatcaatt atttttggtg ttttagtttt attatcaatt 180 ggttttggtt taattctaca tttttttaac tcaaataatt taagtattca attaagcttt 240 attattaatc tcaataaata cttagttaat attactaaaa tattagatta tatcggtttt 300 gctttaattt atttaccaat tattttttta ttaggttgtt gaattactgg aattaatggc 360 gtgcacgaat cattatacta tcatgtgttt atttgattat tttatttcat tagtgttatt 420 ttattaatca ttaccatttg tttaagtatt gcgacacaca tatattatta a 471 94 360 DNA Ureaplasma urealyticum 94 atggaaaaga caataattca attggaattt aatgaagaag aattagcatc aataaaaaaa 60 attaaagata aaatggatcc taataataat ttagaattaa atgtattttt aaaagattta 120 attaaggatt tagcgcgtga ttatttaaat ttttcaaacc aatcatttga aagtattgca 180 aagcaaatga atgatttaaa agatctaata ggaaacgtag cgaacgatcc atctagtttc 240 gattttaatt cagtaatgaa tgaattccaa aagtttagta aatcacaaaa ggatgaagaa 300 aaagaaataa aaaacgatac tgaaataaaa actgcgacta aacctactaa aaaatcttaa 360 95 945 DNA Ureaplasma urealyticum 95 atgaacttaa taaataaaga acttttttta attactggtg acaatcgttt aaaaatggat 60 caaaaaatta atgaaattgc gacctctttt gatgaattag ttaaaattaa tgatcaagaa 120 atttcattaa tttcttttaa aaatcttatt gaacaagatg atttattcaa tagtaataag 180 atctacttat ttaaaaacgt taactgattc gaaaatttag aacatttaaa aaatgttagt 240 gatttaattg attatttttt taataatcat gttgctatta ttattacaat tgaatctaca 300 aaaatttcta cagcaaaaaa aattcaagaa acaattgcaa aatttaatca tcaaattact 360 tttatgacat atacaaatga aaatgctatg gctttcttaa aagaagagtt aaatcagcgt 420 aatttatcat taaataaatc tataatgcaa acgattattc aaaaaacaaa ttttaatatt 480 aattttctta ataatgaatt agataaaata gaattaatta atgatttttt aaaaaatcat 540 ggtatgtttg atattaataa ttttatatgt gattatggtg aatatcaaat ttttagttta 600 ttaaatcttt tgtatcaaca taaaataaat gaatcaataa atttaattaa taaaatgctc 660 attgacaaaa ttgatgaact cacaataatt aatatgttag cgacaataat gagtacacat 720 tacttaatta aattattaca tgaaaaaaaa tataacaaaa acgttatatc tagctcttta 780 aatcaaaaac cttatattat tgatttaaat ttaaaattaa ttagaaatta ttcagctaaa 840 tttttactta aaaaaatgta tgatttatta caattagaaa ttaaagtcaa ggaaaataaa 900 attgataaat attttggatt aattaattga gttttgaatt tttaa 945 96 1269 DNA Ureaplasma urealyticum 96 atgctaaatg cagaattgtc aagtgcacaa aaagatttat ataaatcaat taaattatat 60 ttaaacacaa tttttttgaa tcaaaaacta aattatgcta ttaaaaatga taatgattat 120 cgaaatcaat taaataaagt aatgaatatt tttgaatatt atgaagataa ttatgaaata 180 gcaaataaaa attttcatag ttattgacag gcttttaagt catatgttca ttatgaaaaa 240 atagttaatg attataacga ttttgatgaa ttaaaagata ttgtaaatgg tttaaaaatt 300 tatgttttaa atacatttca aatagattta gatcaagaat cacaaagaat tgcagatatt 360 gattttaagt atgatgaaaa gacgcaagca tcaatgggtt tttatactcc aagaaatcaa 420 gaaaataata ctagtacaga atatgaaaag gtaagtgctg aatctattag tgatgaagat 480 agtatgaatc atacttatca accaacttct gattttacaa cagcaaatat cgataattta 540 acaaatatgg tatttagtgc tcgggttatg aatggtgaaa tttatttata tgaaacgaaa 600 ccaaaagtta ttcctttctt aaaatatgtt ttttttgctg ttagtttagc tttggttttt 660 tttacaacat taacgtatgc ttttctaatg gattttggca cacatatgtc aagtgttatt 720 aatgttaatg gtattactca tattgttcgt ttagtttcgc caacatttcc aacccagtta 780 gtgatatcaa tattcattat gatttatgct ggaataaatg cttttaaaag aaaaattagt 840 gaaaatgaga agtttcattt taaaaatttt atttgaatta ttttgtttgg agcattatta 900 gtagttgcat tagcaaatat ttttactgga aatttaagat tttcaagtag ttcatttgat 960 gaaatgtttc gtcaagcaca aattaatgat gtattagcta acttagcaag aaataatagt 1020 tttagttttg attattcgta tttacaaagt attttttatg gctatagtat cgcccaaatt 1080 ttagtatttg tagttattat tttaggaaca attttaatta ttagtacttt tattttaaat 1140 cctaaacgtg atattcaaag aataaaatta ttattacaag aaattcatga tgatatttta 1200 acaggtaaaa ttgatcctaa tacatattta agaacaaaaa atccctttag agacttgttt 1260 ggtttttag 1269 97 303 DNA Ureaplasma urealyticum 97 ttatttaatt tttttaatat ggtaaaaatc atttttatta gttcgtttag tgtaagaaat 60 aattgtattt gtgtatttat caactaaaaa ataataacct ttatttttag ggtccatgta 120 aatatggaaa ttattgtcta aagaatttaa aggacgaatt cctaaaattc gctcattaat 180 aattggaata atgaatgtac cacttagatt tttaatgtta acatcagttc attcagcacg 240 ttctcgaaaa cgagctaatg catgatctgt aattctaaat ttgcttttat aataatatga 300 cat 303 98 261 DNA Ureaplasma urealyticum 98 atgatgaatg atagtgttaa acaaaccaat aatattgatg aaaatcaatt aaaaccaact 60 acaaaaagct tttttgatga taaaaacaac caattaacaa aagttttaaa tattcctagc 120 gttgttaaat atacggaatc aaaaattaaa aaaaatggta aaaatttttc aattaattta 180 atcattacaa ttacaacaat gtttattgta attgggatta ttataactat tgctattgct 240 attggtatta aattaagtta g 261 99 2043 DNA Ureaplasma urealyticum 99 atgttttata ttaatttaag ggtgaaaaca atgatggaaa aattaaaaaa caacaagact 60 ttgtttttga atgtagaaca agctcaaaaa ctagggatta ataacccttt aacacaagag 120 atttttttag atgatcaaaa gttaaaagtt catttaatta atagtataaa agatgagttt 180 tacttaaaaa aaagtattag taaaggttat gcttatttta atagtttaga acaatttaag 240 actatggagc ttgatgtttt agataactat caatttgcaa aaatagcagc tactaattta 300 gatgagtatg atcaattagt ttacacaaaa actcgtcaat atttaattaa taaagaattt 360 tgaactaatg atggtttaga tgcatttatt ggtgatgatt ttaaaagaaa acaattaacg 420 agcaaagaaa tcgttaatct aaaaacaaaa tatgatttat gaatacaaga attacatttt 480 aataatgcac gaattagtaa acaaattcat aatttaagta ttcatggtca aaataaatta 540 gattatgaga aattttatga taaaaaagca acccttgaat caaatttaga tattcttcaa 600 attttaattt atttaagatc ttcattactt gagttagatt ttgacgatct ttttaaagat 660 gatcaaaata aaataagtat tcgtcaatta ttagttaatg atttagaata cttgccgttt 720 tcatttcaac gttatgatta tgaatcaaga cgtaatttca ttagaaactc acgtcaatta 780 gttgatacct caattgattt tgacgatctt gaatatgatt ttttgcacaa taagaaacca 840 aaacaagaac tagaaaaaaa taatgaatca attaaaatag ctgaattaaa aaaatttgaa 900 aattcacaat taagtgatga acaacaatct aatttagaaa aagagttcta tagtattgga 960 agaattaact gttttgacga agttagcgaa aataaacaag aattaaacaa agaacaatta 1020 gtaatcgata aaaaaaatgg gtatttgaag ccacgtagtt acttacgtca tcatgaaact 1080 ccatttatgg ttgacattga gaaccgggta gactttttaa tggcaggata tgaaattatt 1140 aaaaatgatg atccatatgc aattaaacaa gaaatattaa aaaataccat tttagaacaa 1200 caaaagcttg tcgaacaaga tgatcatgat tttaaagtta aaaatgatga tcaagaagca 1260 aatgaagaat tattggacaa tactgataaa ttagaaaatc aagattctac aagtgctgtt 1320 gaatttaatg attcatctga agttactcaa gtagtaaaaa cggatgaaaa tgttgataat 1380 ttaattaaaa ctaagcaaat aactagtttt aacgatctta aacaagagca atcatctcaa 1440 gaaaatatta ttaaaaatga tctttcatca attcaaattc gtttagatga aattattaat 1500 gtacatgaaa aagatactaa attacaaacc gaactaaatt caattatgat agatagtaat 1560 gaaaaaaata ttgatgatag tttaaataat ttaaatgaac aaatacgaat tcaagatcaa 1620 gaattagaat catcagataa tcaaaatgta attattgaag aagaaattaa taccaaaaat 1680 ttaaataata aagctgatgt tggtgttatg agtgttgaaa aaaaatatga acctgaagag 1740 gaaatggtta attttgaatt tgaaatacct gaaaaccaaa aagaatcagt taaccaagat 1800 gttttaaata gtaatagtat tgataatttt aaagaagaaa aagctaaaga aaatactttc 1860 ttaacaccaa aagaaataga aaataatgat ttatcatcac aaattgaatt aacacctgct 1920 gattttgaac ttaagacaca agaaattaat gacgaaactg aacgtttatt ggatgaatta 1980 aataataata aacctaaaga aaagaagaaa ttttggacat gatttaactc aaaaaaaaga 2040 taa 2043 100 1308 DNA Ureaplasma urealyticum 100 atgaataaaa ctaatcaaat tgtggattta ttaaccaata aacaaaataa ttcaattcaa 60 agacgcgata atctagtttt tgttaaaaat gaacaagaat tcaaagatat tttagattct 120 actattagct taagtaatgt ttatgatcct ttgttaggta atggttgtga acaagaaaaa 180 ataaaagaat taactatttt aaataatagt gttgatatta gcaaaattga agagtatact 240 aaaacattag aaagtaaagt agatgattta tacaataatg tttctaacca actaattcaa 300 gattatcaaa aaaatgagaa tacaagtgcg aataatataa ttatgaaaaa tgaagaatta 360 ttaaattctc atttaaaaga agtcgaaaaa atttgtgaac agctaattga tgaatgaaaa 420 attgaaattt taggggaagt taattttaaa tttcaacaac aattaataga aatcgatcaa 480 aaacaagaac ataaattgaa agtaaaatca ttaatcaatg aagatagttt tttaacaaaa 540 agacaagtta aaaacaaaaa taaaattctt actgaatttg aaaaacatcg ttcacaaatt 600 acacaaaatt atttaaataa acgtagtgat attctcaaga aagaatatga tgaattatta 660 aaagatgata aattatttga gttaagctca ggcgataatt gaaacaattt taaaaaaata 720 actttattta tttctaacga gatcggaatc attaatgatt tagaagatct attaaaccat 780 caagaattaa ttcggactcg aaattataca aaacgtgcta ttttaaatca acatcatatt 840 aatggtcact ttaaagatga aaaaaaatat ttgaaatctt tgtatgattt acgtgttaaa 900 tttatgtatg gtttaggttc agaaattgtt attttaaaat ttttaattga gcattataaa 960 aaattaaata gtttacgttt aagattagaa acattaaacc accctctttc aaattatgct 1020 gtttattttg atattttaaa ccgaattgaa aaacaaacac aattgttagc aaaaattgaa 1080 actttaaaat atgataatta tgattttaat gctgatgtta ttttagatga tttagaaagt 1140 aatatcacaa aaataaatga gattaaacat aattctaatg ttttaaataa aacaaaagtt 1200 attaaaacga ttattgagcc aaaatatgaa ttagaattaa tttcaaaaga tgataaagtt 1260 gatggtgtta aggtttacgt taacgatcaa gaaattcttt ctaaataa 1308 101 1887 DNA Ureaplasma urealyticum 101 atgattgaca agcaaaaaat taaacaacta atccaaaatc ctgtttatgg attttttgat 60 gaatttaaaa aaaatttaaa cagcgatctt gatcatgtaa ttttagaaca attaaaagat 120 caagataata atattgataa aattaatcat ttagtaaccg atattaataa tttaaaaaat 180 gatattaaac aacgcaaaaa agatgaaaaa attaaacaac ggactttttg taatattcta 240 atcgcagttt gttttgttat tattattggt ttgttttttt tacattttta tttgaaaaat 300 tccaaattta ttaaaaattt taaaaagtat gaaattgaaa aaaataatca aattaatata 360 tgtaacagcc aaaaaaataa atatatttat aatgttttat cacaaattaa ttcttataaa 420 atttcgcaag aaatttttgc taagaatggt ttatatttaa tgccagaaat tcaatatgaa 480 aatattaaac aaaccgattt attaatttca cgaaacgcaa aatttgttgg attttttggt 540 ggtttagaag ttaaatttaa aagtacggat acttttttag tgtattataa ggaattttca 600 attaaagatg ttgtaacaag tggttgtatt caaatttctt atcgaaaagg agatcaaatg 660 gttagtgaaa cgatcgttgc tcatcataag gaaccaacac cgtttgttga tcttcacagt 720 aattttgttc ataaaactaa ttactctcca aactttaact tttcaacgta cgctcaaact 780 gttaattctc gttcaaaaac aattttttct aatttagaat tttctaagta ttatggctta 840 ggaattgcta ctcaaaattt agaatttgat acaaaaatgc tagaattttt tacgcctttt 900 agtcaagaaa actatgaaaa ttttgctaaa tatttaaaac aagatgatat cacagttcct 960 atgtttacaa aaactgcgac atcccttatt attgatgatc aattattaaa agataataga 1020 aaaccattct ttataaattt attaacaaat aatagttatg taaaaacttg tgattttcta 1080 attgatacag atattaatgc ggacctacaa acgaatttaa atattttaaa atatgaatta 1140 gtaaaattat ttgaaaaata tattttatat ttaactacaa caagtttatc aagtgtaatt 1200 gcccgagaat gatatattaa taatgatact tataaaattg gtgataatta cgattatgaa 1260 agttattatt atactaatca aaatcaatta actccactat cagtttcgac aaaacttttt 1320 ttaaaaaacc aaatagcttt tgttaatgat tgtgaagtaa ttccttttgc tgaactagtt 1380 aataatcaaa cacgattcgg cattaataaa gcacagttta atattaaaag ttatcatgtt 1440 tataatcgtg tagataatgt accagtatat gcgcatggca gaacacacat tgttcctgta 1500 caatacaaag agtacatcga atatgaatat ccatttattt gtttatatgt tttaaaatat 1560 aaacagttaa cagaagaaat aggtttaaaa tattttacac gcccatttaa taatatttta 1620 ttaacaaatt ttgaagatca tagtgcttgt tctattgatg aaattcttga ttttaatgat 1680 aatgaatcca aaaataatag cgataatgat tttaaaattt atttaaaaga attagataca 1740 atcgtcacaa atgcgaattt aaataaaaat gaatttagct tcttaaaaga caatgatggt 1800 tatttcatta cgataagtaa taaaatagaa ttagacgaag aaactgaaca agaattatca 1860 acttgattaa gaaaagtaag cttatag 1887 102 576 DNA Ureaplasma urealyticum 102 atgatagatc gtaaacaaat tcatgttaaa actagattaa caattaatga gttaaataag 60 ttttatactt taattagagt ccaaaaacaa agcttaaaag agattgaaga taaaatcaaa 120 aaacttgatt gaattaactt tagtgagatt aaaaatcaaa atttatttga tgaatttaaa 180 tttgattata aaaatatgac accatatgtt atttcacaag ttcaagatct ggttagtgtt 240 tatgatgtaa gacaaattag tgaaataatt cttgaattaa atcaagttaa tattcaaatt 300 caaactaaag atagtgagtt ttatattaaa aataataaaa aattaagttt aattagtagt 360 gaatttgaag attatcaatt aaaaaattat gatgcatatg aacattttaa aattacaatg 420 gatgaaccta aaattcatac tttaaatcat caaatgccat ttgattcaaa attaaacatc 480 aaaaccatca tttttatagt tttaacttct tgtttattat gtttattaat cgtcataatt 540 atatgtgcat tattaattgc aggagttatt aattaa 576 103 288 DNA Ureaplasma urealyticum 103 atgaattttg atattaattt aattaatgaa aatgattatg tttttagtgg atacattatt 60 ttaaaaaaac acaatgaaga aattatcgaa ttactaactt atttaggcga tgatcctatt 120 aatgatgaag ccaaaatcat aactttatat aataatgatc atattgatct aaaaaatctt 180 aatgatggag atttaattat tgtaaaagca agtttaatta taaataataa aaataacaaa 240 caattattgc ttaaagatat taataaacta gagttaagta ttaactaa 288 104 915 DNA Ureaplasma urealyticum 104 ttagtaaatg ttaatatctt gagtttgttg actttgatca atttctttat tattaatgtt 60 aattaaatta gtttttttat ttaaacaacc attttggtat tttgatttta gtgactctgc 120 tatttctttt tctataatga ttaaatctaa attatcaaaa tcttgtttaa ttactttttg 180 taattcaaaa attttttcat cactatccat atcaataacc ataatgatgt ttaattctgc 240 caaaccagaa taaatataat tcattattct cattaaatta taatcagcat tcatattaaa 300 aacaaaacga tggttatatt ctttgatccc ttcaataaat aatactttac gttttagtat 360 aaatttgaat gaattaatta aattcatcct tgcgatcaaa taatcttcta agctcatttt 420 attagttcta ggtctaattt ttttaatcat gtatatatat aaacaactaa aaaataaaaa 480 aaataggact aataaaatca atacaactac actaggactt gaaaaataag cttttcaaac 540 ttttggaatt aattctcatt gatcgacatt taagattgat gatccaccag ttaatccatt 600 aatattagaa ggagataaat ttttcataat aatctgtcca tcaataatta aatctccttt 660 aaattgacca cgacttaatg taattgattt gataacacag tcaataattg gccttgcaac 720 accagcgaga atacatacaa ttaatgcaac gatacaaaat aaaaaaaaga tttcgattaa 780 tcatgaacgt aaagaacgtt ttgcatgtga aatttcagga tttaatttat aatttgtagt 840 ttgaaatcat cattccatga aataaaatag aattttactt tttttcttaa tatgagcatc 900 aaagctttca cgcac 915 105 1737 DNA Ureaplasma urealyticum 105 atggtttatt ttttgtttaa agtagttgta tatttaatta ttataaatag agtaaggact 60 aatcatttta tgaagatgaa agctaagaaa tttttaatta caggattatt aggtgtagtt 120 agtttagcaa ctattaccac agtagctaca gcttgtacaa atggcaataa tcaaaaggct 180 aatacagtaa ataataagtc tgatttaaaa acaaatccaa atattaattt aactcaacaa 240 gatgtagaaa atttggaaaa acaaagacaa caatgaagtg aagatttaga tgtttatttt 300 aatggtgggt taagtaaaag tggcaaaaat tttgaccgta taaatacatt atcatcaaat 360 gcaacggaat gatttaagaa tcatcaaaaa ttagcggcaa cacgtgattc tggatcattg 420 gtacaagatg atgcagctta ttcatttgga attgcacccg attatgttca ttataaatga 480 gtttcaaaag atggtggcga cgtttctcca tcatatttaa aaccatattg aaataaaaat 540 ttaactgaag gtagaaactt ttcaaaatta gacccaaaga ctttggatga taatggaatc 600 ggtgttttat taatatctga tcaccattat ggtaaatgaa atgataattt tttaagcaaa 660 aaaactgttg gtggattaat tatgcaatca cgagtttctg gtttgccatc acactatcct 720 gctgttctaa caccaaaatt tttatttgat cctaatttaa atccaaattt aaaaaaatat 780 gcttctgcta attatgcgtt acctaattat tactctgacc cactagatgg gattatttta 840 acaggaaaaa ctttagatcg tatttatgat gctaaaaagt tttctaatgt ttataatgca 900 catgtagctg gcaaaacaca ttttgagaca ttcacagatt ttgcaaaggc aatggttgat 960 gaaacgcgtc gtggaatttc acaatgatct ttaaaaaatg ataaatgaaa agataaaaca 1020 gttttaatgg ttatgcctaa ctttactcca acagctaaaa tggtagatgt taattttaaa 1080 ccagaagact tagaattctt gagtaatgtt tgcattaatg aacctatgta ttgtccaaca 1140 atatatagtg atccaaatga taaatattta cctggattag gtgcaaaatt ccctattcca 1200 gtaaatcata tttcacaagt gcaaaattat attgatgatt atggacaaat tggtggaaaa 1260 gtattaaatg gtactggtaa tccagaagca tcaaaacaag ttggcccaac tttaggtgat 1320 gcttttaaag atacaagtga cgttgtagtt ttctgttata acgaatacgg tttattaaat 1380 tacaaacccg gaactgaaga aggcgaagct ttagtacaac aatttgaaaa gaatttaaca 1440 aattatgtta atggtttaac aaaagaaaca aaaaatcaat ttgtgccaac aaaagtttta 1500 aaagaaaaac cagtcgtggg taagaatttc tttattgaac gtaaaggtaa gttctatgat 1560 gcatgttatg gttttgctgg tcaagattta gtagttaata cattaaataa atgaacaagg 1620 ggagctaacg ctcaaaatat agatttaggg tatcctattt ttaataaaaa tacagttaaa 1680 cacattagag catttaagga ttctttaggt gttaaagttt tagacaaaca aaaatag 1737 106 1635 DNA Ureaplasma urealyticum 106 atgaaatata aaaaaatttg aattacttca atagcttcta ttgcttttat aacaactatt 60 gtaagtacaa ctacagcttg tagtaaagtt aataatgaag ttaagtcttc aaatgacatt 120 tttaaacaaa tattaccaac taaagaagaa cttacaaatt taattaaaag acgtaaggat 180 tgagctaatg atttacaagt ttattttgag ggtggaaagt ctgcttcagg aaaagaattt 240 gagcgaattc aaactttagc aacaaatgca agtatatatt atcaaaagaa ccaaaaaatt 300 gctatgacgc gtgattctgg ctcattatgt caagatgatg ccgcatattc atttggaatt 360 gcaccagata tttctaatta tcgttgaaaa gcaggtgatg tagaagaagt tgtaccacat 420 tatttatctt acctttataa tcctaaatta actaaaggta tggaacttaa aggtgttaaa 480 gcagaaacat tagctgctga gaatgtaggt actttattta ttgcagattt taaatttgga 540 aattataaaa ctaatttttt agataaaaat aaaataggtg gaattgttat gcagtcacga 600 tcatcaggtt tgccttcaaa aacaccagct ttattcatgc ctaattggtt atttggtaaa 660 aataaccctt atttagagac tgacgttaac gcttcagctg gaattacaga tttttttgtt 720 gatccatatg atggcttaat ctttacaggt aaaaccttag atcgcattta tgatgcaaaa 780 aaatttgata atgttaataa agcggttatt gatggtaaaa gcaattttca aacatttaca 840 gattatgcaa aagcaattgt tagtgttgta cgaaagaatg tttcgaattg agctaaacaa 900 catagttatt gaaaaaataa aactgttgtt atgacaatgc caaacgtaat gaaaggagca 960 cgaattattg atcctaattt tagtaaagat gatttactat tcttaggtaa tatttttatt 1020 ccacaacctg tttattttcc aattttatat gcagaccaaa atgatgaata tacacctgga 1080 ttaggagcta aatttcctat tcctaaaaaa gatataaatg aagttcaacg ctatgtagat 1140 aattgaggtt gaataggtgg agcaatttta agtgatgcta ctaatcctga tgctgcaaaa 1200 cgtgttggtc caacattggg tgaagctttt gaaggaacgg ttgataaagt aatttattca 1260 tataatgaat atttaattaa aggatataaa ccaggaacag cagaaggtga agctataatt 1320 aaaaaattcg aagctaattt agcaaaatat gtaaatagtt tagatataaa tacaaaaaat 1380 agttttaatc ctacaaggat tttaaaagaa aagccagtgg taggtaaaaa cttttttatc 1440 gaaagaaaag gtaatattta cgatgctaat tatggattta taggtcaaaa aactatggtt 1500 aatattttaa atcgttgaat gaatggtgaa aatagtccag aagttgattt gggtattcct 1560 aattttacta aggataatgt taaacattta cgtgctttta aagatgaatt aaatgttaaa 1620 aatactgatg aataa 1635 107 1635 DNA Ureaplasma urealyticum 107 atgaagttga agtttaaaaa aatcttatta tctatatcaa ctagtttaat aattttatca 60 tcaattatta caattgctgc atgtagcaat caagtaaaat ctaaaacaaa tttttcaaaa 120 acaacaccaa ctttagaaga attgactgag cttaaaaaaa gagaagaagc atgaaaagct 180 gatttagaag tttattttga aggtggagta agtaagtcag gaaaaaaatt taatcgaatt 240 gaaactttat catcaaaagc tagttcttat tatcaaaaaa accaaaaaat tgcggttact 300 aatgattcta gttcgttatg tcaagatgat gcactatatg catttggaat cgcacctgat 360 tattctggct ttcgttgaaa aacaagcgaa cttgaagaag tacatcctca ttatttaaat 420 tatttataca actctaaact aacaaaggga atgaatttca caggtaaagg agcattacca 480 gagaattttg ctaaattaaa tgtgggtaca ttatttattg ctgattttaa attcaataag 540 tataaagaaa attttttaga taaaaatgaa attggtggtg tagcaatgca atcacgatca 600 tcaggtttgc cttcaaaaac accagcctta ttcatgccta gctggttgtt tggtaaaaat 660 aatccttatt tagaaactga tgttaatgct tcagctggaa ttacagattt ttttgttgat 720 ccatatgatg gcttaatctt tacaggtaaa accttagatc gcatttatga tgcaaaaaaa 780 tttgataatg ttaataaagc ggttattgat ggtaaaagca attttcaaac atttacagat 840 tatgctaatg ttgctgtaaa agctgttcga aaaagagttt cacaatgagc aaaacaaaat 900 aataaatgaa aagataaaac aacggttatg attagtcctg atgtaatgcc aaatggtcga 960 attgtagatc caaacattac taaagaagat ttattacatt taagtaattt ttttattacc 1020 caacccgttt atttaccaat tttatatgct gatcaaaatc atccttatac acctggaatg 1080 ggttgtaaat tccctattcc taaaaaacac ttagaagatg tacaaaaata tattgataat 1140 tgaggttgaa taggcggtgc aatattatca tctagtgcag aaaatcctga tgctgcaaaa 1200 cgtgttggtc caacattggg tgaagctttt gaaggaacgg ttgataaagt aatttattca 1260 tataatgaat atttaattaa aggatataaa ccaggaacag cagaaggaga agctgtaatt 1320 aaaaaattcg aagctaattt agcaaaatat gtaaatagtt tagatataaa tacaaaaaat 1380 agttttaatc ctacaaggat tttaaaagaa aagccagttg ttggtaaaaa tttctttatt 1440 gaacgtgaag gaacattctg cgatggttgt tatggtttta tgggtcaaaa aacaattgtt 1500 aatattttaa atcgttgaat gaatggtgaa aatagtccag aagttgattt gggtactcct 1560 aattttacta aggataatgt taaacattta cgtgctttta gagatgaatt aaatgttaaa 1620 aatactgatg aataa 1635 108 525 DNA Ureaplasma urealyticum 108 atgaaaaata agtattttag aaaaaataaa ttttggttat taataccaat aagttttgta 60 agtcttggaa gtattacatt agttgctact gcttgtgtaa agaaaaattt ttatcctaat 120 acatttgcag atgatcagat ttatatcact aagaataatg aaaaaactgt taagtttcgt 180 attagtcgta atgatgaaga aaataaaaag tattttaaag atgatcttaa atgaaatact 240 ttcattaata aacttaaaaa aacttatatt aatgttgaaa ctgttattcc aaaagaaaac 300 gcaaaacaaa atattaagca acaagattta tgcatgcgcg cattacctgt acaagtttta 360 agtaataata aatatgttga tatttacgta aagattcctg ttttattagc taatactaaa 420 atgttagttg ttggtgatga tttactaaaa tcattttatt ttgatacaga taacttaata 480 atgaatgcta aacattttca accaattcct atcaaaatgc tttag 525 109 636 DNA Ureaplasma urealyticum 109 ttattgctcg ttttttgctt ctagtttttg ttgcttttca agacgctttt gttcacgttg 60 acgtttcttt tcttcttgtt gttcatcaaa acgcttttca gcagcaacct tatcttgttg 120 agtttgtttt actaattcaa aaatctttca accagcatct gacataccat tattttttaa 180 acgacgatat ttaacgtatt tgccagattt aacaggtgtt tttggttctt tttcttcttt 240 aatactttct tgtttattaa cttgattatc ttggttaaca taaacaattt tctcaacaat 300 tttttcgatt ggcttttcaa cttcaataac tttttcaata taaacaggtt tttcaacttc 360 aacaattttt gtattgctta ggtttgttaa atcatttaaa tcaacacgta atttaacaat 420 ttgtgtttca tgatttaatg acacttcttg ttcataaaca ttattagttt caccatcatc 480 actatcataa ttttcgtgtt cacaataatg gttatattca attgttttta attttctttt 540 taaattatca actttattag ctaaatcacg aagctctaat aattcgctaa tttgtggatc 600 atatttttta ttagttgcag acatttgttc ctccac 636 110 105 DNA Ureaplasma urealyticum 110 ttaatttttt tcaacaactt cttctaaatt tttgctattg ttgcgtttta aaatttcttc 60 ataaaaaata tcagtaatga gatattcaag ttgttctctt gacat 105 111 228 DNA Ureaplasma urealyticum 111 ttaccttttt ttggtagcct tgcctgtttg cgaatttata ttcataccta aattatagag 60 tttatatttg gttttaatta gttttaaact atatttattt agttgccttc cattactaat 120 ttcacaatat ttatatgata aaaattcttt agaaatatca taatttaaat attgttcata 180 tcaaaaaaat attgataatc attcatcttc tcttaattgt cttcccat 228 112 729 DNA Ureaplasma urealyticum 112 ttatttttgt gtttctatgt taacatttaa caatttagca ttggttaatt taacatcata 60 atttgcatta tttccattca ttttatcttt taaatcaatt tctaaaccat taagatttga 120 taattgattc tttgttaatg atttatgaac tacttgtaaa ctactatctt ttttaatttc 180 aatatcaaat gttaatatag gttgattttc ttctaaagaa tttaaaatat caaaattttg 240 taatttaaca ttaattttct tattttcttt gttgaatgtc ataaataatt ttgcattttt 300 aacatatgat tttaacaact cttcttcatt aaatttgact tctttaccat ttaaagttag 360 ttttgaaatt tcatagtcaa catttgaatt taaaccactt agtttaccgc ttaatgtttt 420 agatgcttca tcatatttta aatcacttgc ttgaattgga tttgtatcag ctttcttaat 480 aacttctaaa acaaaatctt ttttattagc atctgctaat tcaaatttac taaatgtaac 540 ttcaatagta gcagtattat ttttgacttc actaattttt acaccactag ctacaacatc 600 atctttttta gaattttctg gttgatcagc ttgctgttcg ctaccaccat tttcttttgg 660 ttcttcagtt tttggagctg gagtcggaga tggttgttgg cttggagctg aagctgcttc 720 aaagttcac 729 113 1641 DNA Ureaplasma urealyticum 113 114 1182 DNA Ureaplasma urealyticum 114 atgaacaaac caatgtgttt gcttcgttta gataattatt attttacatt gttggtattt 60 atttataatg atgtaactaa agttaatgat ttaattttta taaaatctat tccaaacaat 120 aatcaaaata attatgaatc atcaaatttt ttgcaaacag atttaaaaat ccaacttaat 180 acattgatta actgttttaa aaaagaattg cacattaatt ttattgatga aattattgtt 240 agttatggtt ttagtagctt tcaaactaca catactactt tttataacta taatgaattt 300 atgaaattaa gatcaaattt taataatgaa cacagtgaat tattaagttc agatcaaaaa 360 agttatatag cagttgattt tggaataagc cactattcta aagaaaatag ttataagttg 420 atttcatatt atattttgaa atatgattat caattaataa ttgatttgtg ccaatcattt 480 aatttaaaaa ttaagcaatt tatagtttca caagctcatt taaacggttt aaaatttgat 540 aatgaagata ataaaacttc attattatta gaattagaaa attttaaaat aaattttaga 600 acttataatg aatataattt aattagtaat gttattagtg agacaaaaaa ccacttttgc 660 ctggctgata tcattactca aacagcacaa tcattaaata ttaatcctaa aaagattgag 720 agctacttta atgatattaa ttataataat aaaaaagtta ttgaaattaa tattgatcct 780 aaagagttgt ttacttatag ttttatttgt ggtgcggata ttgaaaatac ttttttaaaa 840 atttttaaag aacattttga aaaaagtatt ttatctcaat ttgatcatcc attactagat 900 tttaatccaa agaatttagc ctttcttttt attaacactc ctttcaataa tttaaataag 960 atattttatt atttttttag ttcatatttt aaagaagtta aaattgaagt ttttcaaaat 1020 aaatttttta tttattcaaa ttgttatgaa tatagtaata gtcaagccct agctaagcaa 1080 gatttttaca atgtacataa catgaaaaat tttgatagct ttagcaatga aaatatccta 1140 acaaagatgc atgatcaaac aataaacata aaaaattttt aa 1182 115 876 DNA Ureaplasma urealyticum 115 atggcgttaa gtaaacacag tattggtttg attaaaaatt taaagaataa aggattgact 60 attaaaaata aagaaaaatt cattagtttc ttgtttaatt atggagtcat aagagttata 120 gatggttatt catttttttt aaaaaaagat aatcaatatg taaaaggctt aaaaagtaag 180 gatttaatta attttgtttt attagatcgt aaaattgcta atttaatggg tgattgtatt 240 atgctatttg aacaacaatt aaatgctatt gttgttcaaa attttttaaa gatcaataat 300 ttaaattcaa aatatgttat agatatgcga acagatcctt ttataaaatt tgaatcacca 360 aaacattatg aaatattatc agaaaatatt tacacatatg ctaattcttc taatttgtta 420 agtcaattta atactaacgc acaagaaatt cctttaatta atttagcatt atcatgaaca 480 ttaaatacca ctattggctt ttatcgtgca gttgataata atgttcaaat tagtgtttta 540 gagtattttc aattaaatca tattacacca ttagaattta ttgatatttt acatatcata 600 aaacattttc gtaatagtat ttctcataac gatatggtaa ttactaatag tttcaatgat 660 aacgtaggtg catttgctaa atcattaaaa ttaaaaagta ttaaaaaagt agtgggattt 720 ttagatgttg cggctttttt aacggcgttt acaaacgata aatttcatgt tttaaatggt 780 aatttacaca tcaaaatttt acaagcaatt aaaaaagcaa aattcaaagg cgttgtttta 840 gaacatatta ataatttatt aggagttgaa gattaa 876 116 816 DNA Ureaplasma urealyticum 116 ttgaatttaa agtcatttga atttttaaaa ggtgatgcaa ttgttgataa ccaaataaaa 60 aaagctatta atactagttt gattaaagca tcattttcat gtgcaattat gtgtatatta 120 gttcttattt ttggtttttt aatgcgaaaa tatttatttt atttttcaga tgcatctagt 180 ttaattatta gctctcgttt gatttttcaa ataattacaa tcattgttgc tactttatca 240 attgtctatt ttattgttca tttaatcatt tactttagac aaagaaataa ttttttagct 300 cctaaatttg catgatcaat catattgtat ctattggatg gtattacaat gtgttttatg 360 attagttatg tagcggcgat tgtaggatta gatttgacgt taatagccat tggaattagt 420 ttatcaatca ttgtcgcaat gggaatacta ggttttatta tgaatcataa aattgctttt 480 aaattaggca ttgctaatat cgttttattt actattgcta caattggttc aattatttta 540 ttgattgtat tttttacaac gagatataac catactggtt ttaacaaagg tgttattatt 600 gctgacattg tattaagtat tatttgattg ctcgctttaa gtattggttt tgcttcgacg 660 atttacatta ttaaagtaat ggccgaacat cataatttag ataataaaaa aataatgcgt 720 gattttacaa cttgaaatag ttatttacta tttgcttcat tcaatcgtat tttattatat 780 gtaattcgtt tgtttttatt gtttaaaaga gtataa 816 117 1784 DNA Ureaplasma urealyticum 117 atgttaaaaa attattttca atcaagttga ttatatacaa cctttttatc acgtttggta 60 ctttttaaaa aaagcacata ttttttagta ggaattagct tatttgttaa tttaattttt 120 ataattataa atggtttaaa tattgctaat aatataaaaa cgtatttgat tttattttat 180 ctttttacta gtattaattc acttttaaca atagtcttta gcactattaa agctattaat 240 ttattcaaag atttaaagga tgaaggaatt gaaattttag tcttttcaaa aagtatttca 300 cgtaaaaaca ttatttttac taaaataggt tttttaatat taaatattgt tttttgaagt 360 ttaataactt atattttaaa tattattttt tacgtagtaa atataaagaa taataacggt 420 attaattttt tttatttata tgcttttttt aattattatt tctgtggatt aatttttgct 480 agtattgctg ctttaattgt tagtcgttga tcaaataaag ttgctatgat tattccaatt 540 agttgttttc tccccttttt aattgctggt ggtgttgcta atttgtattc aacatctaaa 600 attaatcaag tagccaaata catgaatatt aattatgata aatatgatag taatacaatt 660 ttagatgtag aaaaatttta tttaaataat cataatgatg aagtttattt aatcactaaa 720 aatttaaata atccacaatt tagtaaacgt cagaattatt ttttgaaagc agcgtttgat 780 cacgcaaaaa atgcatcgac attttttcat gtcttatctt gattatctgt tccttatcaa 840 ttaaataata gtttttataa gaatgatatt gatcctttta gtgttaatag ccaacacgaa 900 aattatttag ataaatattt taattatcat ggtttagaat caaaattata tgattataaa 960 cttaacaaac accctcattt accacaattt aatattaatg aaaatcaaaa agaatatttt 1020 gttcctggag ctttaaaaaa tacgagtcaa ttcccaacac ttgagaatcg taatttaatt 1080 tatgcgagag aaaatgtaga tcgttttgac gttaatttca ttgaggatga taatttattt 1140 tcatcaacta atgattttgt tggtgaatta aaatgagcgg ttattagaaa tacattagaa 1200 tcaaaagttt tcaataactt tgccaaaaaa ttttatgata attttgatga agatattgat 1260 aaaccacaaa ttattgctgc ttataatgat gtaattaatg aacaatcatc aataaatttt 1320 tcaacaatcg ttgatgaaaa tagtattcta tttgctaaaa agataaataa ttattatgtt 1380 aaaaatcttg ttgaaaagaa aatttatttc attgtagctt taatgtatta tttatatttt 1440 aatgaggaac gttgaaatct tttagaaaaa ttattaaaaa acgataaagt tattaatttt 1500 tatcgtccat catcaataag aatcaatgta aataattatg catatgatat ggagggattg 1560 gaagttatga attaatgaaa aaagtagtta ataacaaaac tttatatcgt taccaactac 1620 aaaaaagtaa taattatgtt tttcaaacag caaaagaagt ttattctatt aaacgtgctg 1680 atcaaattgt taataaaaat tattattgat taatttgaat tttatttagt acgattttaa 1740 ttataagctt ggctttaatt tatttaaaac gagattataa ataa 1784 118 300 DNA Ureaplasma urealyticum 118 ttatttcctt accggacgtt tctctcaaac atcaaaagtg ctttttttat caacaacttt 60 ttctaaaaga tcaataaaat tatttagtga tgttgtgtat tcacgttctt tttcgaattt 120 tcttttatat tcattaagtt cttctatttt taatattgca tttttatgtt catttataaa 180 tatttctaat tcattaatta attcgtctaa aaaaacatct acactttcag gatcgtaacc 240 aactttgtta gcaacaaatt ttttattttt atactcatta attttattat catttaccat 300 119 282 DNA Ureaplasma urealyticum 119 ttaagaattt aaataataaa tattcatata gggaatttta ggaccaacta ttgtactcat 60 atctacatta attgtttcta ttttaatcga atctatatct tgtgaatcgt ggttttgttg 120 tgatgaacta gccattacaa tatttgttat gcctccaatc atagaaatag ctgtattagc 180 aataattgtc ccaaataaca ttttatttca aaaacctaat gctccagaaa caagtggcat 240 aaatcctcca taaatcatgt ttttattaat tattctttgc at 282 120 279 DNA Ureaplasma urealyticum 120 ttaaaaaaat ggagttccta aactaatcgt tgaattcatt ggtttttgtg cgattcttgc 60 ataagtgcga gcaacagagt tatcgatcat ttgttgagga ttaaattttg gttgagggtt 120 aaaagcataa actaattgtg aaatcattcc taagaatcca acaactgttt gacctaacat 180 tgatgaaatt aaagcgttat ttcacatata attaaaagag ttagaagttg aaaaaccacc 240 ataataaact tttttaaaat tatcagatat tttttgcat 279 121 606 DNA Ureaplasma urealyticum 121 atgaaattta agaagtttga tagtaaaaaa tcgattttac gttttttaca agttgatgaa 60 acaaaacgtg aaattaattt gtcttttaat gacacaactg attttatttt ttttctaaaa 120 gaaattgctg aagatcctaa tattgctaaa aagaatgcta aaaaattaac tagcttatac 180 attgaaatta gtaataaact gggtaatgat gacaacactg atttaagcgt ttatgaaaca 240 aaatgtaata atttaattga agcctgtgtt attgatgaag caatctattt agttaatatg 300 gcaaagaaca tagtcatttt cttagctcat aacaaacttg atcttttaca aaaagatttt 360 tttgataaat tattattaat agaatcgcat tttaattttg atcaaaatct tacttattca 420 tatattaaaa actcatcaat tgcgttattg atatttcatt taaagcaatt tattaacatt 480 tatgatgaat ttttaaacaa ttttgaaaat gttattaatc atagtttaga aaattcaatt 540 tcaactaaaa ataaattaac ccaacaaatc aatcatttta atactataaa acgtcgtcct 600 tcataa 606 122 1606 DNA Ureaplasma urealyticum 122 ttatttttgt ttattttctt ttgctggatc tgttcaactt acaacttttg ttccttcaac 60 agattgtaat gtgtttgttg tacgatcata gaattcaaaa ttaattggtg aacgagaatt 120 atttgaatcg ccacgttcag taggaacagc ttttggtatt gcattgccaa taagagtttt 180 aaaagaacgg ttaatatgag aattattacc acctagagca tataaattca taccagcaac 240 tttttgagca tcaccagtga aatctttaaa ttcggttttt gtttcatcta ctaaatcagc 300 taaaaatcct ggtagtttag tatatgtttt tcctttttct ttaacgaatg aagcatagtc 360 tggttgaatt cccaatgcca cacaatgatc tcataaatta tagaatcaga ttgcaaattt 420 attatgatca ttattagaat tttttggacg aatgtgtttt aatgtttgtt ttgatggcat 480 agttcaatca agactaacac ttgctaattc actatcactt acccctaatc ttttagcaag 540 tgattgaact aaacgtactg ttccaatagg tcctcaaatt gaagaatatt caaattgaaa 600 atcaactgga ataattttgt tattattaac agttttctta aagaattttt caaaatttga 660 ttttaaaatc tctccatctt cattgccttc aagattgttt gagtcataat taaagaaaac 720 ataatccgca gttccataaa aagcttcttg cattgatagc attcaatcat agtcattttt 780 tgacgcatta ttttgggatg caccaattcc atgtcagtta tcaaaatatt tatcagcatt 840 atggtttttt ggtttaggaa aacgtaaacc aaacccagga acatttgaat catctggttg 900 agaatacaat aaagggaata aatcttcttg ttggaaatag tataaatcta atttagatgc 960 atctgaacta ttaaaacttt gtgttgattc tgctcataaa acagttgtat tattatctct 1020 taatttttta atagttggta aattagcaac ttttctaaca tattcacgaa tcttattatt 1080 aagttcttta gcatactcta aaaaacttgt tttaccgcta tttttcaaag gttcatgtga 1140 tgtaatttca taacctgcat catccaatga ttttgcaaac atttcaaaac atttataagg 1200 gtctgttagt gaattaaaaa aagtactact attattaaca tcacttaaga tatatttttc 1260 actagattta gttgcatttt gttttggagc tttttttgaa attaacttat taagtgttgt 1320 ttttccttcc tctttaacgt tattgtcttt tcttgcacat gctgtagcag caaccgcaat 1380 acttgaaatt aaaacagttg aaaaacctac tagcaatact gctaaagatt ttttattttt 1440 cttaaacata tttttattat cctcattttt aaaataatat tgttttgttt tgacaaacaa 1500 tttcattcta atagtaaaaa gaaaatattc tatgatttat ataccaaaaa atccactttt 1560 tgatgtccaa tattagtttt agaaacaatt ccaccgccaa tgcaat 1606 123 450 DNA Ureaplasma urealyticum 123 ttattccttt ttttcatgat gttcatgatg acaaggtttg cataaatcca ttttattcat 60 atataaatta attgttttgt aatttaattt aacattatat tgtgtttcaa gaattttttg 120 aattttacga caaccaatat aatgcttatg acttttacaa attttttcaa ttaaatccat 180 atttcttttt ttaattggac aaacttgatc tatttttaag tcttctagtc atttataata 240 accagaaatt gatacatcaa acaacggaat taatttcgtt aaatgcattt ggtggttttt 300 aatcaattca tgaatcattt taaatttttc tttttttgat tcatgatgac gataagcatt 360 aattacctta ataatatgat tttgttctca ttcttcataa tgattaattc ttaatgcatt 420 gatatcaatg ttatcgacaa tttttgacat 450 124 213 DNA Ureaplasma urealyticum 124 ttataaattt tgttgtttct ctttaataat ttttttgatc ttttcacgtg ttttcttatc 60 aattttttca tattctaaga tatatgataa ttcttcaatc gaatgttctt cgtacggttt 120 ttgttcatca atatcattaa tatcgaaaat agatgtttct tgtacttttg aacgctcaaa 180 taacttttca aaatcacttt ttttatcact cat 213 125 504 DNA Ureaplasma urealyticum 125 atgaacatta aaaaaattaa acgtgaattt aatactcatt acgaattgat taaaaaagaa 60 attaaaaact taaatgaata taaaaaagaa ttagaattct taattgcaac aatttatttt 120 aattctaaaa tggtttttaa agaaatatca ttagatagtt gaaaaaaatt tagcgattat 180 gtttatcgat tttttttaat aattaataaa aataatcaat cacaaaattt tgatttagat 240 tgttgatact tagaaattaa agaattaata aaagtactaa atattagtaa ttttttattg 300 aataagcaat tggaacaaat atatttgaaa tacataattt tttattggta taacattaat 360 attccaataa attatgaaat tgatgatttt aatattattt gtttacgcaa taaagcattt 420 gtagattgta tgcaaatttt acaagaatat tatcatatta atgttgatat tttaattaat 480 ttagttatca aacaaattag ataa 504 126 810 DNA Ureaplasma urealyticum 126 atggtttgca tcattttaaa aataaaaaag ggaatgttaa agataatgaa taataataaa 60 agctacatta aaaaatattt tgatgatatt ttaatacagg ctaaacaggt tttaaaaaaa 120 catgattatg cgtatgcata tgatttaatt tctaatgaat ttaataatcc attaattgat 180 ttaaaaactt tacaagaatt tgaagcattt gctatagaaa ttaaaaaaag tgccgaactt 240 aactttattg atgaaaatga ggcaaaatta gctaaaacag atttttattg taaaattcat 300 gatccaaaaa caacttatgt tagtttagca tatttagaaa cttttttaat gcgtttcatt 360 aatgaaatgg atgaattaga tattacattt ttaaatagct tgctaacaaa taaattaatt 420 aatggatcaa caaaattaga tattttagat ttattagcaa ctaataatat tgatcaaaat 480 tttaattttt acaataaata tttaaaacaa acaaaaaatg ttaaccctgt taattttaat 540 aaccattacc aagaaattga ccaaattcaa aattatctaa ataagtattt agctaaaaat 600 ccttctttat tacatttagc caataaatta ttaatgatgt acattacata ttattttcca 660 tttaaatttg cacataatca taatttaatt gctaaaacaa ttattgatta tgtaaaaaat 720 gctatggaaa atcatgtttg tcagtatagt gaagaacaaa aagctattgt ggcttgtatt 780 aataaaattt tagaagaaga gcaagtataa 810 127 975 DNA Ureaplasma urealyticum 127 aaacaaattc ttgattcagc aaaaaacaaa aatccaactt ttcacatcaa cgagtgaaat 60 gcatcatttg catatttaca acaatttaat gcaataattg gtgaaataga agctaaaaaa 120 gacaatttaa ataatcaaaa tttttctaaa gctaaaacta ataaaattat tacttttgtt 180 ccttatattg aacttgattc taataaatat ttaacaaacc aagcaatttc taaggataca 240 agagttaatt gaatatctgt tattaaccaa tatgcgaata ataatgaaca taatttaatg 300 gcaactagca atgatttact aatttattct aatttaaaac aaacacctaa ataccaaata 360 gataataaaa aactaaaaga agattttgtt aaaaataata attgactaag cgaaaatgtt 420 gattatcatt taagtatttt taaagatatt aaatatgatt tttatctaag ccattggtgt 480 tatcaatatt gaattgatca aaatcgttta gatgttattt taaaactaat ttataatgct 540 aataaaataa ttttataccc gaatggaaat gctgaattat attatgttgc aaattattac 600 gcacaggcaa ttaaaaattt aattagggaa gatccccatt tatcaaaaca aaagattaat 660 gatcatttaa ataattttat taatatgaaa tcatttttag aagcaaaaaa ttattttagt 720 tcacaattaa ataataataa agattgatta acagtttttg tcttaaataa gttgtttaaa 780 atttttacaa ttggtgaaag ttgagtcgat tctaagtact ttagttttaa taaggaacta 840 atgcctaaat cttataaaat tcgcacaaat tatgcaagcg tactaaattc actaaattta 900 tcattagatg ctaaaaatca atttaaaaaa aaaattttga gcacactttt agaatataca 960 ataaaacatt tttag 975 128 552 DNA Ureaplasma urealyticum 128 atgggttctt cactatttaa aaataatgtt ttaaaagatc gtaaaattgc taaacaagaa 60 ttacaacaat gagcactaaa aattaaaaac aaatatccta atgctaatta cttttttaaa 120 ttacacccta tttataatca aaatcaagta ttagattaca ttcaagaaat cactaatgga 180 atctttaaac caattatttt agatgcaaaa acaccatgag aaaatatctt attaaaagat 240 tatttatcaa ttaaaaataa caaagcagtt ttatttaaaa acaaaaacac acctaatttt 300 tcattatggg gttttcaacc aacaacatca gcacttctaa cgagttttga ttttattcgt 360 aataatacta aactaacaaa tgatgaagcc caatcaatta taggttttga taatttttta 420 cttggtaaaa attatgacat tttaagacgt gattatgaac caaataaaga ttatacaaac 480 gaaaatttgc aaattttaga aagaatatat ggacaattaa tttttgctaa aattttaaaa 540 aaattctttt aa 552 129 252 DNA Ureaplasma urealyticum 129 atgatttata aagaaattgt acgtaatatt attaaacatc cattaatttt accagatgga 60 aaacactatc atctacacaa aatcttaact tcaaaagatg aattacgtaa aggcgaagta 120 actttagttg cagaaaatgg caaagaatat acagttgatt tatctgcctt tgttgatcta 180 ttagttgatg gtgattgcat ctttgatgat aaccactcat tagttgcatt atattttgat 240 gatgcaaaat aa 252 130 1500 DNA Ureaplasma urealyticum 130 ttatttagta gacaaataag ttgatcataa ataaaattca ctaacactaa aatctgctaa 60 ttctttagca tcatcaataa tacccatttt tactaagtat tgtaaaaatt cgttttttat 120 attttgcatt cgggttttta atgattcatt tttagttttt aattgattaa tttcttcatt 180 atttttatct ttgttaatac taatttgtca ttcgttttca tataactgtt ttaataagtt 240 taaataacga tcttcatagt gtgaatttat aggattagtt tctattaatt catctttttt 300 agctttaatg taatcagtaa tatcataatc tcgtcaaagc atgttaataa tactaaaacg 360 aattttatca ttcattaatt tagtattaga tgtactaatc gaataatatt tattatcata 420 tcaatatgca tttacaaata aattgaactt attaagttga tcattaatgt tttcaaaaaa 480 tcgttttaat tcattttttg tacttgaata ttctttgtta tttaaaaatg atttttctaa 540 aaagatatta aaatctaatt tattagttat ttcataattt tgatcgatta aattttcttg 600 ttttaaatac ttaataatta aatttttatt ttcatcattg ctttgattaa gttttttaaa 660 cgctaaaaat aaagtgttga ttcttgtttt atcatatgtt tttattttaa ataatatacg 720 attaacgtta gagaaataat acctatcatt tttataaata cgacttattg gatagctatg 780 attaatatat ttacttggaa gatctaaatt aaatttttga ttgtaatact tgtataattc 840 tctagcattg taataatgat ttatatgagc aaaataaatg aaattgtatc aagaataaaa 900 ataatcttta ttattagaac ttaatttatt aggatgataa tattttttaa atattcttgt 960 tgcttcatca aaataatgtt ctggatctct taaactaata tacttaatag aatttgctaa 1020 aaattttggt ttattatcaa taaaatatgt cacatttaaa aacatataat aatcaattaa 1080 tcatttaaat caaggtttgt tttggttatt tttaactaat tcaaaatcaa ctaaattact 1140 tatatgttgg tcaatgtatg ctagtaattt attaacaaat tctaaatcat aggtttgttt 1200 ttggtcatct caaactttac catcataaac aaagctttta atattattag catataaaac 1260 tttgtaataa tcattttttg gaatatcaat tattggtgat agttctttag tttttggttt 1320 ttcttgttgt ttattttctt tgatttctat ttgctttgac aatttattag aattattgga 1380 ttttgattta ttagttgtac aaccaataat caaaggtgca attaaaaata atgataataa 1440 gctagtttta atgaatagct ttttctttaa tgaatgtgta actaaatgac gtttgttcat 1500 131 1353 DNA Ureaplasma urealyticum 131 ttaatgaata gctttttctt taatgaatgt gtaactaaat gacgtttgtt catttcttac 60 ttctcctttt tgataaacta aaattttgta ttcgccttta tttagatttg gtgctctaat 120 taattcaaca ttcgaatctg attctgaacg ataaatgttt atagttctta aaatttcgcc 180 aaagttatca aaattttgat aatcaatatt ttttagatct tcatttttaa ctaaatagat 240 atcataattg tcatttttaa aatatgttag ttttttatat tcgttgtata cactattata 300 atcatgtttt tttgaaaaac tatttgatgt tggcttaaat aatcatgata aagcaaaatt 360 gaaattagtt tgatcattat caatacttat atccatttct ttaactagtt gtttatcttt 420 gtgtttcgtt aaaatttttg tttgttttgc gtttttatat gcttctattg ctcttttaaa 480 atctaaatga ccagcaccat ataaatgact aaaactattt ttataaaaat cataattttc 540 attatttttt aaaggaattg atgaagcagc taaaattgag cgaatatgtg ttagtggaat 600 tgttttatta gcgttattaa ccatataata agattgcaat aaactaatcg caccagtgac 660 aataggcgca gaaaaactag tacctagatt tatattttta tctcctttat ttttaataaa 720 ctttgtaatt attgaagtgt cataaatacc ttctccagga gcaactaaaa atggcatcaa 780 taaatctcca tatttatttt taacatcatt caagtgatgt cgatctgaaa aattacttac 840 tttttcatta tttttattag tagatcctac atatattgaa ttttgattaa atctatccat 900 aaaactatat ttagatatat caaatcaatt aatttctaaa atatgtccat ttttatttct 960 atatcgtatt tcatcattat aagaatttcc agctgaaaaa atatttataa tatcaaaata 1020 atatgatatg aaatcataaa tataattttt aaatttatat ttattaatag tattattaac 1080 aatatcatcc ttattcaatg tatctatata tttttttaac tctcttttaa aatctttatc 1140 atcgtttatt tctttaccat taataaaatt ataaaaacca atatttaaaa aatcatttgg 1200 acttcatcca taactatggt taataatttt tacgtcattt tgtattaatc aatctaactc 1260 ttttcaaatt ttaatatgac tattttctga tgtttcatcc tttgcattaa tatctagtga 1320 ataaagatgg actttctcaa ttttcacgat cat 1353 132 1251 DNA Ureaplasma urealyticum 132 ttaatatcta gtgaataaag atggactttc tcaattttca cgatcattta aattcattaa 60 ctttatttca attgattcat ctttatttat attattaaaa ttaggattta atgataaagt 120 taaactttgt gaagtacttt cttcttgtgg tttattaaaa tgagcatcaa aataaacttt 180 tgaaattaaa tcatgaacag taatgttgtt attaaaaact acttgcattt gataatattg 240 ttcattatga ttgattaatt cctcaaaaac tcaaatttta ttttctttat ctcaatactc 300 aataccagta aatcgataat tccctgaata caattcttca aattttaaat cttcatgatt 360 taagaatgtt agggcattaa caggtaatgt tttaattact ttaccatgtt catgttgata 420 cactaatcgc attattttat actgtaatcc agattttttt gataacaaac tttcaaaatc 480 atcttttata ggattggttt taattaataa atgatcattg ggcgttggag tttgttcaaa 540 taaattagta ttatcataaa aatctgcaaa aaactcatca cttaaacgat cttctacatt 600 ttcaataaat tcttctctta attcaagcaa atcttttgaa taaactggtt caaaacttgt 660 tccactactt gaatcgattt gacaaaattc tccaacatct tgatcaaatc ctcattcatt 720 ttttaaaact aaatttttac actcaccaaa tacagccatt ggtttttgat caatcttttt 780 attaaataaa ataaatttaa ttttattaat aattacttga ttaataaaat cactatttga 840 taatgattca agttgtttta agtccaattt attattaaaa ataattaaat ccataaaagg 900 taaataatca aattcattat attgatctac acctgatatt tttgcatttt taattcaagt 960 tttaattttt aaatgttgct caaaaatttc tgtttttgaa gcttttgttg tattaaaaat 1020 caaacgaata attaatttat ctttaaaata atctttattg ctttcatcaa tttcaataac 1080 actataacta attttgtttt gattttgatt gtcaaccaaa ttaacttgtt ggtttagttt 1140 cgaactaatt gtttgttgac ttttattttt tgctaacaaa ctaaacgatc ctaaaaccat 1200 cgaacttaaa cttattgtcg acaataatat tgctttcttt ttaaatttca t 1251 133 1887 DNA Ureaplasma urealyticum 133 ttatttacta ttattttcaa tcttttgcga agttccattt tgtatttttt taacttcttc 60 aattagtttt tttagttttt tattataaag atctaacgta taagaagaca cattattatt 120 gttaattcct tgttcaacaa atttagtaaa tttttttaat ctttctactt tagattcgtt 180 atttgttttt ccattttttg tttcagtaat tttcttactt tcttcaatta attctttagc 240 ttcaggaata tataattttt tatcaacaat cgtaaaaatc ttaacactaa aattttcaat 300 atcttttgtg aacacccttt cttgattatt atctaatttt aaatagttaa ttaactcttt 360 tggttttaat aaaaaatcat tagaataagc taaatcaata ttttctagat tatcaattgt 420 taatgtttga tttgcactaa gttttaaact gactttagta tttattcaag gatcattttt 480 ataactattt aaaacatctt gaattgtttg ggttttatta gttttctttg cttgatcatt 540 ttcactatta actttagtat taaattcttt tagatgttta atgaaatctt tgaataaata 600 agttttttta aagtttgata gaattgtttg tttgatttga tcaacaattg aactaatttt 660 agtattagca tcttcaaatt ttttagttaa ttcattatta agattatttg cactatcaat 720 cgttaagcta tttgtattaa agctaaataa actaataatt gattgtaaat tttcaatttg 780 attttctaaa ccattatatg tagcttttga actattgttt ttgtcttttt ggatattttg 840 ttgtttttca atactatagt aaggattgta atcgtctggt tttaatgatt gaataatact 900 aattaattta ttaatactat tttcactatc taatgcaatt gtatttaaac cttgtaaata 960 attttgtaaa tcatttaata atttattagt taaagattta atttgttcaa tatctaatga 1020 ttttttaaca ttaacaatat tagtgatatt cttgtttaga ttttgtttta aattagttaa 1080 ttttaattga tcaaatcata aaaaactata attttgttgg taaatagtat taataacatt 1140 aacaatatca tctaattttt taataaaagg taaagctttt agttctttgt taattaaatc 1200 attaatatca tttaatttag tgtaaattaa tttaaaatct tcatatagtt ttttaaaatt 1260 agcttttgtg ttattattaa ctaatttttg aatatcactt tcaatctcga caatattttt 1320 atttgatcca gatgttttaa ttaaattttt aattttatta gctaaatcta aaattgtttt 1380 ttgaattaaa gctttagtgt gcaatctttt ttgatgagca tcagatttta gtttatcaat 1440 tattgtagta tcaacacttg cttgattaag taatttttca tattgattta aaaaatcttg 1500 taattgtttt ttagtgtttt ctaattcaac aacatctatt aaatcactca tgtttttgat 1560 tgaatctaat tcatttaaaa cactaacttg tgtaattaaa tttttaattg tttgttgttc 1620 ttgttttaat ttttgctctg ataatttatt aatgttttct aaatttgatt taagagtttg 1680 attatatatc tttttaaaat cttcataaga tgattgatca actatttctt ttaataaaac 1740 agctttattt aaacttgatt gtaattcttc tttagctttt tgttttgtat caacttttgc 1800 acaagctgta attattgttg ctaacaaagg tatagcacta atcatactta gttttaatca 1860 aattcatttg tattttttgt gtttcat 1887 134 177 DNA Ureaplasma urealyticum 134 ttaaagtaac aaatctaata aatgtttaat gtcaataata aattttactt tattcgcaac 60 tagttgttct agagttttgt taatacttgt gttttttaaa agatcaaaat taactttttt 120 atttaaaaca gcatttgaac tagctccata aaaataaaaa tctttttgat ttttcat 177 135 426 DNA Ureaplasma urealyticum 135 ttattttaaa ataaaatcag ggtatgaatt acttatttga ccatcttcat taaaatattg 60 atattttaat ccatgaaaaa caggattttt agtccaaagt tcaacattat ttttaatttt 120 atcattatca tttgataatg aaagaaaacg atttgcaaat ttagattcag ttgaagaatc 180 aaaatagtga ttttgttctt taagatcttt atatgcatac ttatcacaaa tgtttaaatc 240 taacatgttt tcacattttt tatatttttc aataggaata aaaatttcat tttgattagg 300 taaattttta ttattttgta atttaaaaag taattcatga ttatcttttt tcatttgttc 360 taatgaattt ttatataatt gttcaaattg atcaagatat tttttgataa taacatatca 420 atacat 426 136 1017 DNA Ureaplasma urealyticum 136 ttactttttt gatgatttgt ttgctgattc agtttctcat catgtttttt tcgaaattgg 60 atcactttga aattcttctt caattaatac tgtttttaat aataattgtt gttttttatc 120 taaaccatta ttaatgggta aaacatcatc aattgctttt tctatttgtt cttttccatt 180 ttttttaaca attaaatcat ggccacgatg atgacgttgc gctttatgtt tattatggtg 240 attatctgga tcaatatgtt catattcttc ttctataaag tattcattat taggaaatac 300 tgaactttga ggtgctaata aacattcatc ataaactagt tgtgctagtt cagcttcatc 360 acgtttattt caaacactta catactttga taaccaacta aaatcatttt gatcatcatt 420 aattaaactt tctttttcag aaaataaaga ttctaaaaat aaattttcag catacacttt 480 ttggtttgaa taaatatttt caaaaacagg ttcttcaaat tcaaaagaaa caggagtaaa 540 aggtgtatgt tcttttactg aattatcaac ttcatcaact ggagctacaa tattctcctg 600 tataaattct tcattgcttt gattttcgtt ctttataggc tcaggttcaa cttcttcatg 660 taatggttca ataggtgtag attcatgttc gttaacaata tcatcttctt ggttattaac 720 tggagctgat gatagatcat tgcaatcttg taaaatttgt ggttcatcca ttacaggtat 780 ttgttcttgt tggatgtttg ttaaagctaa attacgtaaa cttttaatcg tttttgtgta 840 atcaactcac ataaaaacgc cacaattttt gcatcttact ttaacttttt tagtaacaat 900 agtttcatca tataattgat aaatatcttt gttattatct aaaacatcag taatatttat 960 atttttatct tcagttaact tttgatttaa tttatttttc ttactaaata atcccat 1017 137 3399 DNA Ureaplasma urealyticum 137 atggagtttg atatgaaatt taaaaaaatt cttttaacaa gcacattaag tgttttaggg 60 gttatttcaa ttgcaagttt agctacaaat tgttcacaaa cgaaaacaaa aattaaccag 120 tataaaataa ctataaataa attagatagt ctaaatttaa caagtaattt aactacaaaa 180 caagctttaa aagatgtttt attctcaaaa gaaggacaaa atgaattttt attatcaaat 240 gttaaaaaag tggtttatga ttgagcaaaa aacaataatg atccaaaatt agctcatgat 300 gttagtgaat ataatacaca attagatgaa caattaaaga gaattaaaga aaatgtaaaa 360 aaatcatacc caaatgattg acaatctgtt ttacaaagcg aactatatga tactgaaggt 420 ggtagtgaaa aatcatgaaa agaagctaag ttaattgatc aagcatacaa atcaattact 480 tcttcaattt ttgatgataa tgataattga attagtgtat taaatgatca aaatcaacta 540 attgatgcct attcaaatga tgctactaag ttgttagaga atgaaagtac ttttaaatca 600 actaaaattg gagatagaaa caaaattgtt gctaagacaa ataatttttt acaaaaagga 660 tacgctaatt tatttaattt cttaattgat gattatatta aatataacct gcctttatca 720 tttgccaaca ttgaatttaa atatgatgat ttaaaaaatc aaaacattta taataaagat 780 ttttttacaa aaataccaac ttctggcaca tcacctaatt ttccttgatt tgatcctaaa 840 ccaactgata ataaatcaac taacactaca actaattatc tagaagtagc taaattatta 900 aaagaaaata aatacttaga ttcaaaagat gatacgaata atattgacaa aaaattcaac 960 aacaataatg atattaataa atatttaagc ttaaatgatt ttattactca agacaacaca 1020 aatttaacat taagtgtcgg tttattagct aaatttttat cattatttgg aaatgaaaat 1080 tttggtattt atcaattaga taatttagat gaaaataata ttttaaacaa ttttattagt 1140 aagaatcaaa gtaatgcaaa cacaaataat gttgatttat tttatccttt agttaaaaaa 1200 gataaaacag cttttttaaa tgattttaag gatgttaaag ctatccgtca aattaatgat 1260 ttaaaaaatg gatatactct attacgtaat gaaaacagtg ttgatttatg aggtattaac 1320 aattttaaaa gacttcaaca agcagctaaa ataggtttga acgctctatt aacagagtta 1380 aaaaatgatt ttttatacaa tggtgcacta tacttaaatt cacgcaaatc aaatagtgtt 1440 aaaaaacaag gctatgatat taaagctaaa attaaagatt actttaataa caataaagag 1500 cgcttattag cactatatat tgctacacat caaaacgata gtgatttttt gtttaaatca 1560 aacttaaaaa atgattcaaa agtttttgca tttgatcaaa gaacaattaa tattattaaa 1620 gaaaacaatg aaattcattt attaaattac tatgataatt taattgataa gttaaatgat 1680 aaattaatta aatttaataa aaaaacattt attattccta gtgttgatag tttatatgat 1740 aatggaatta atacaccaat ttacttaatt aaagaccaaa atcaacaaat tagtttattt 1800 caaactttaa aaataaaact agtgggtaat aaaaatctta tagatgaaaa tcaaaaatta 1860 tctacaatga ttaatgatta tgttgaaaac tttgatataa aaaaacacct tgttgctaat 1920 aataaaaact cccaatcaat tgtttttgac gattatgtta taaataaagt atttagtaaa 1980 ggaataaaca gtgtttttgc aaatattatt aaacaagaac aaattaaaaa aagtgtagca 2040 aaattctttg aatttaatga ttttaatttt aaaaataatt ttcttgaaaa ccaagaatta 2100 ttagcagcat ttaaccaaat tattaagaat acaagtgttt tggaaacaac acaaactaat 2160 aattttagta attttgataa cttaaaaaaa gtttatgaac aagctttgaa attatgaaac 2220 gataattata ctaaaaatgg cccttttaat cagttatcaa tcaattatca aaaataccaa 2280 gcattatttg aaacactcgc tattattaat tacttgttag attttaaaga tggtaaacca 2340 acatatcaaa atttaattaa ttacttgtta aaaaaaactg ctaatcatca accattattt 2400 attggttgaa aagctttaaa tgatgtaact aaaattccta attttggaaa agattctaaa 2460 gaagatttta gtttcaagaa ataccaaatt aatttatata atggacttga cctataccaa 2520 ttaaaaaaag ctgatgttta tgaaattgac caaaatagtc aagaagttaa attcaaaaaa 2580 acttttatag atgcattaac atacactaac gataaaaatt attgaaactc aaccgttaat 2640 aaagatggtt cagtttataa taattttatt ggcttaattg atcaaaataa tcaaaaagat 2700 aaattaggta aagcttttga aaaaatcgac ttgtttgata aattagttta cgctaataac 2760 ccaagtaaac aatttaaagg tgcactatat ggttatggta gtagagaatt attaattaaa 2820 acattagatg gttttgtgtc ttatcatgac taccaaacac ttgcacaatt actttatgat 2880 ctaaatttta atgcagaagc taatgctgaa tttaaaacta ttttagataa ccaaaaacaa 2940 attattcctg gcaatcaaaa agatagtaaa ataaaaaata ttgatttagc aactaatgaa 3000 attaaaacaa ttatgattaa aggaattaat aaaatccccc aaactgcctt tcaaagatta 3060 gatttagatt tagtttataa caaattagac aaaaatgcta caccattagt taataaagaa 3120 gataatgcta atttaaaata tattttatta gtttcacaat ttaatgcaaa tgatgtgcaa 3180 aatttagtta ttaacaatca attaaatcaa agtgcaacag gatatttagg attgtcaaaa 3240 agccaatttt ataacttatt atttgattta gcattaaatg atcaaacttt aaaaattgaa 3300 gcttttagtc aaattgaaaa cgaacataaa attaaagttt acgataaacg tttagctaat 3360 aatagtaatt taaaaggttg aatcataaat aatctataa 3399 138 471 DNA Ureaplasma urealyticum 138 ttactcgctt tcttttttag tatcttcttg ttgatcttta atcacttttt gatcttcttt 60 attatttttt tgaaaattac gaaaccaatt cttaactaat tttttatctt ttaattctgg 120 aatataaacg tttgaataag atcaataagc aaaaatatta atattaataa taataattaa 180 aaacgaactt attccaagaa ttgaaccata tttaaatatt ttaatttggt tataaggaga 240 atctaaatga aaatttttgg ttttaaaaat tttaataata ttttgttttc attcgttata 300 ttcatcaatt cgcgcataat aatctttgat atagtatgat aaacgaacag ccgatcagat 360 taaaattgct aataaaattg ctacaaaaac atatgaaata atcgtaataa ttttaaaacc 420 ctcgattgtt tttaaaaaat cataaaattt tttacctttt ttgttattca t 471 139 819 DNA Ureaplasma urealyticum 139 ttattttcct ttttgatcat cttcaacttt atattttatt cgttcatttg ctttattacg 60 cttttttaat tctaaacgtt ttttgttaaa ttcattataa tattgttctg aatctttaag 120 ttcattgtat agatctgcag catatgtctc aaaatgtttt gagcgattca taatagcatt 180 tgtaattttt gtcatgataa aaattggtaa aataaaagca actactaaaa ttaaaaatcg 240 tactaaatat cctcaaattt gactaggaat aaatccagaa ataattaaaa taaacattcc 300 aaatcaacat gaaactactg gcgtaagaat gtctcaacga atctttggcg tactaaaagc 360 aaatataata catacaataa ctgctaatcc taaagttgaa aacattgcaa ctcaaactgg 420 atatgaacta attatatttg taccaaattc aacaccatga ttgtattgat tagtaatttc 480 attaactaat ttttgcattc tttcaatcat aagaggaccc ggttttggtt ttaattgatc 540 atatacaata ggatttcaat gataaaaatc tttaactcct acaatccatt gttggttttc 600 atctaattta aaaccttttc catatcaacg accattaaca ccaattattc cattaaaacc 660 taaaagattg atttcaccat ataaaataaa aaaaacaatc attggaatga caacaaaaaa 720 tgatgtaatt aaaaatttat ataaaagagg tgatttaaaa cgtgtattag tttcaaaggg 780 ttttctaaat caagtagttt ttgaatgcct taaattcat 819 140 252 DNA Ureaplasma urealyticum 140 atgatttata aagaaattgt tcgtaatatt atcaagcatc cattaatctt accagaagga 60 aaacattacc atttacataa aattctaact tcaaaagatg aattacgtaa gggtgaagtt 120 agtttagttg cagaaaatgg caaagaatac actgttgatt tatctgcatt tgttgactta 180 ttagttgatg gtgattgcat tattgatgat aatcattcac ttgttgcttt atactttgat 240 gaaagtaaat aa 252 141 192 DNA Ureaplasma urealyticum 141 atggaattag cagctattgc tcatgtatgc acgcgtatgt taacaccact agtaagtatt 60 aaattagtta gtgatcatat tactcttccc aattccaatc aagaacagtt taataaaaac 120 ttatcactaa ttgataaatg atttaatgag catttaccat ccattattga agcaatttta 180 gagatctact aa 192 142 2328 DNA Ureaplasma urealyticum 142 atgaaatcaa ataataaaaa ttacaaattt ttgaacataa aaaaacggaa atatcgcatt 60 ttttttatgt tgtgttcttt aaatttaata tgagcaggcg ttattatagc tattgttctg 120 cgtttaaaaa atattgataa acgctttagt gaaaatgacc ataaaattgc tcgtccaact 180 tgagagtatg ataatgatgg aaatttagag attcacactc aattagcaaa tgatttaaat 240 gatgatttaa aacaaaaagc tttaaataat gcaaatgtca aaggaattgt tgttgaccaa 300 aatggtgtag aacatgagat agatgtaagt attgatgcta atggtaaggt tattattcca 360 acaaaagatt tagtaaataa tgacccaact aaacctaata tatacacact taaaaaagtc 420 gttttaaaac aacataatca accaaatatt gatctaatta gtgaagagca attaagtggt 480 gataatcata tttcatttaa aaaaccaaca gtggttgctc aaattaatga taacaatgat 540 tatataatgc attttacgaa tcctaattta gttaacaaga aaattaaatt aacatttaaa 600 gttgatgatc aagatgatca tacaaaaacc attgaagcta tcattggatt agatggaaag 660 gctattttta aaacaagtga tgatgcaatt tttgcaccag atcataaata tacactaaca 720 aaaattgaag ctaataacaa aaaagttgct aacattgatg aaattccatt aaaaaataga 780 atcgttgata aaaatccaat taaaagaatt aacttaacac aactaaaagt tgctaaagat 840 ttaattcttt gaaataatac aaaccaaaac caattcataa ctgctacttt taaaaatata 900 aataacgatt ttgatgatta tattgttaaa ttaatttatg aatacaatta tcgtggagaa 960 atgaaagaaa ttgcatcaca acctttcaaa ttagaaaaaa ataaaacaac atacaacaat 1020 atccttttgc caattagtat tccaaatcgc ttatatcatt ttaaaaaagt agtaattcaa 1080 aaattaaatc aaccaaataa atctattgat ttagatcatg atccaaattt aaaatctttt 1140 tttattgttg gtcctggtaa aacagatttt gcatgaaaaa aaccaaatga tgatcaaatt 1200 acatatgatg gtttaaagag attaaatatt gaaattactt ctcaagatta tgcattacaa 1260 aatggtaaaa aagttatggt ttggtttaaa tcagatgccg aaccaaataa tgattcactt 1320 aaatttatag gcgaattatc tcaaactaac gccaatggaa cagctgctgt cattaataat 1380 ttaaataatt tatacggtat gaaagaacaa acagagtatt acatctataa aattcagttc 1440 atagatgaat tagaatattc aaaattacca ccaaaccgta ataacattgt ttatgaatat 1500 aataaaaata ttgcacgtaa ttatgcattc cgaactaaaa ctgccccttt aattttagaa 1560 aaaatagaaa aagatgataa tggtagcatt ggaggacaaa atttttattt ttacctaaat 1620 aaagctagtg atgatcctag tacaatcaag caagttacta tatattgtcg tgataataat 1680 aatgaattat atacttctga tgatcaagaa atagattctg ttgatcttgt atatcattct 1740 tgaattcatg atttaaaatg aaatcgtgaa tatgtttttg atcatgctga aatacaaaca 1800 acatatcctg atgatcctga atatggtggt gaaacaaatg atttagaaat taaaagagga 1860 ttaactttca agttttatac accaccaagt aaaacagaaa tacagtgaaa acatcctata 1920 aaaataacta ataatggggc aattttagat attcaattac aatcaaaaga tcgggcattt 1980 gaagataagc aaaaatatcg agtgacatta gttgaagctg aaaatcaaaa caatgctgtt 2040 gttggtgact ttttacttgc tggcacttct attaataaaa atgatagccc aattggtgat 2100 aataatgata agaacaaaga tatagcaact ttgagctgta attttgaaaa caaattaaaa 2160 aaagggacta aatacttatt aaaagaagtt cgatttattg ctaatccaaa tgaagaaatt 2220 agtgctaaac ctactagagc tgctagacca tttaataatg ataatattat ttatagtttg 2280 aatctacgaa taaatgatcc ctatgacttt acaactttaa aaaattag 2328 143 3942 DNA Ureaplasma urealyticum 143 atgaaagtaa ataaaataat tatgaaaaaa agagttaata aaatatataa acacaatatg 60 tttattttgc tagctacttt aaatttagtg tgagcaggcg ttatcacagg aattgtttta 120 agactaaaaa gtaaagatta ctcaaagcat actatcttaa aaaaatatta ttcatttgat 180 aaaaacggca atttaattct taaaggttat ttaaaaccac atgataatac taattatgtt 240 tttgggattt ttagcgatga aagcaatcaa gaacataaaa ttcaagcact tgttaatgat 300 aaaaaaggat ttgaatttaa cactaaatca ttaccactaa accatagtta caaacttaaa 360 aaagttacaa gtattaatga ctataaccat gttttattaa caaatgatga tttagttagt 420 cagcaaaaaa tttgttttag taagccagtt gatgcaaaag ttaactttat taataataaa 480 aaagtttatc aagttaaact aaacacgtta ttaaaaaaca ctttaattca attaacacta 540 aaagacttag agcataacgt atataaaatt acagccaaat caaatgatat gggagaagtt 600 agttttgatg tttcacaatt aaaaaataat aatttatatg aggtaattgc tttacaaaca 660 caagaccaaa ctaaaatcgt taatgttaat gagattgaat acaacaataa gatcataaat 720 aatttaaata ttgatgaatt aaatacacca taccaatata gcaaaaatgg tcatcttaac 780 ttaattgcta agataccatt acgctatgct aatgaacaag tctatggtgt ttttgaagac 840 caaaataacc aaaaacattt aattcctgcc gtaaataaaa atgatggaac aataatgttt 900 gatactcaag ttttaactaa aaatcccaat aaaaaatatc atttacaaaa agttgtttta 960 gcaaaaaatc aaaatcaaat tttaatacat aattttgatt tagtaagtaa tcaaaaacaa 1020 gatatcttct taaaagaata taaagttatt agtattagtg ctctagaaaa tgatgctgat 1080 aaaactaaaa gagaaatcaa tttaaaacta tctaacataa aaaatgactg agttaataag 1140 caaattaaag ttatttattc aagttcagat ggttcagatg ttcaaactca acctttagtt 1200 ttagaaaaaa atcaaacaaa ctatgtatta aaactaaata atttaaaagc aaatcgttta 1260 tatacactaa aggcggttga attaataaat aacaatggta aaactaattt accattagat 1320 actaacttaa ctaatagttt tatggttgaa agaactagtg ctgtattagc aacaagtatt 1380 agtgaaataa gtaatcgttt gggaactgct ttaacgaatg cacaagttaa aatcacttta 1440 aaagatgtgg ataatgtttt attagctaat caaaaagcga ttattaacta tggtaataat 1500 caaaagagtg aagcaactgt tattgttaac aatggtgtta agtatctaat agcaacctta 1560 actaaattaa cattaaatac gcctacaata attaaatcca ttacatttga acaaaaacca 1620 acatgtgcta ttgaaaatat tgggttagat aaaacaaata acattattta tcaaaataca 1680 catgaagcag caattccttt agtaattaat aataattttg aaatcaatgg gccattagca 1740 tcaagtcatg aaagtttaaa aagtattaat gcatctgatg ctaaaaaggt aaatgcaatt 1800 aatttaaccc ttgactttaa taccaatgaa catatttata aaaatttatt ttttaaacta 1860 aaatatgtcc ctattgacga tcaaggtaat gaaaatattt atgacgcatc agaagcaatt 1920 tatagtgatg ttttaagtgc aaataatata attgctaata aaatccaatt tagtttaggt 1980 aatttacaaa ctaatcgtaa atataaatta aaaacaattt attatttaac atcaaaaaca 2040 acacctttag atgatcataa cgttgtaatg atcaaaccaa atgttaaatc cgaaattatt 2100 gttgccccta atgatagtac gattgtaaaa tatggtaatt gaaatcaaga ttcaattact 2160 aatggatcaa aggctatttt taaaattaat tgtaatgatg gtgatatttt aagtgaggat 2220 ttaagtgcta cacttgttta tgaatctaat gatcctcatg atttacaatc atacactaca 2280 aaactaaaaa aagttaacaa tgattgggtg attgatttta atttaaataa tttaaaacca 2340 caaaccactt accatttaaa atcaataaca atagcaaaac caaataaagc atatactaat 2400 ttaaaaattc aatcacttcc acaagtggat attaaaacgc aattacctaa tttaatcttg 2460 catgatttaa aagccacaag tgcggtttta aaatgggatt ctactaacaa tggtaaaaac 2520 aatcaccaaa caattcaagc aactttttct catgtaagtg ctaattatga taatcttaat 2580 gttaaattgg tttatgaata taattatcgg ggtgatatca aagcagttga atctgattta 2640 attactctta aaaaagacca aaatgtttat caaataaatt taccaatcag cgttcctaac 2700 cgaaaatata cttttaagaa agttttaatt caagaacgca ataatttaaa caactatgtg 2760 gatttaaata aaaagataaa cttaacagat tcatttgtag ttagccctgg aaaaacaaca 2820 tttgaatgaa cacaaccaac tagtgatcaa attagtcaaa caaccctaaa agcattaaaa 2880 attaaaattc tttcagaaga taaaacgctt gataataatg ttaaggttat tgtgtgattt 2940 aaatcccata cagattcaaa tgatgcactt aaatgaacac ggggaacttg ggaggttaat 3000 agtgatggat cagaagcgat tattaatcaa ttaaataact taagtggatt taaagcagga 3060 acgcaatact atctttataa aattgcattt gttgataatc tacaatatgg aaatacgcaa 3120 gcgaatgata ataaagtaat ttatgaatga aaagccaatg atactaaaga atatgaattt 3180 acaatgaaaa atgcaccaac aattttacaa tcaataaaat ttgaaaattg tgatgctaat 3240 ggtgtaatta ataatgaagc ggaaggaatt gcagaatttt caatgacaac aaacaaggtt 3300 aatgatgatt ttgctaaccg aaaagttaaa ttcatatatc atgacaataa caatgttgct 3360 tatgaaactg atggttttcc attaagcaga tcagaaacaa gtcttcattt ttctttatca 3420 aacatcccta acaaccgcga ctatactttt gaccatgctg aaattgaaac tagtcctaat 3480 agtaataaat atgaaatttg acattctcaa aacaagataa tatctaagtt caaacttaaa 3540 ccagctcaaa cttctgtaaa atatattgat aaacaagaaa gaaataataa taatgtagat 3600 tttgagcttc atttaggttc aagagactgt gcatttgaaa ataaccaaaa atatcgtgtt 3660 acactagtgt cagtagacgc actccaaacc gaaatttcta aggaattttt actttctgat 3720 gttaaattag attatcaaga tggtaatatt ggaatattaa aatgccattt tgataactta 3780 ataccaaaca ccggatatac attaaaagaa attaaatttc ttgctaaccc aaatgaacaa 3840 caaagtgcaa aaccacataa ggtaattaaa ccttttaatg atgataacaa tgttattatc 3900 gataaaaatt attcttgaaa atgatatatt tatccttcat aa 3942 144 1851 DNA Ureaplasma urealyticum 144 ttaatgctgt ggttttttaa tttcttcaat cagttttgtt aatctttgaa tataaagatt 60 aagagtataa gaagaaacat tttcattact tattccttgt tcaacaaaac tagtgaattt 120 ttctaatcgt tgtaattttg ctttattatt tgtatgttca ttttttgttt gaataatttt 180 tttgctttca tcaattaatt ctttagcttt gggaatataa agttttttat caatgatagt 240 aaaaactcta acactaagat tttcaagttc tttgctaaat tctctttctt gattattatt 300 taattctaaa taagcgatta attcttgtgg tttttgcagc gaatcagaag catatgttaa 360 atcaattttt tcaagattat ttactgttaa tacttcgttt ggagcaagtt ttaaattaat 420 tttagtattt aaaaataaat ccttttcata actttttaag acttcttgaa tggtttgaat 480 tcgattagct ttttttattg gatcgttttc attatttaat tcaatattaa actcttttaa 540 atgtttaatg aagtacttaa ataaataaat ttgtttaaaa tttgataaaa tggtttgttt 600 aattttaatc acaacatcat taatttgtga attagctttt tgaaattttt taattaattc 660 atcattaaga ttatagattg catcaattga taaattagta atgttaaaat caaataagtt 720 aatgattgat tttaaacttt taatttggtg ttctaaacca ttatatgttg cttgagaatt 780 gttttcatct ttttgcttat tttcttgttt ttcaatacta tagtaaggat tataatcatc 840 tggttgtaat gattcaataa tactgattaa tttgttaaca ctattttcac tttctaacgc 900 aatcattttt aaaccttcta agtaattttg aaggtcaacc aaaagttgat tagttaaagt 960 tttaatttct ttgatctcta atgtcttttt aacatttaat acatgattta tattctttat 1020 taaaatttgt cttaaatttg ttaatttagt ttgatcaaat catagaaaat gatgattttg 1080 ttcataaata gtattaataa cattaactat atcatctaat tttttaataa aaggtaaagc 1140 ttttagttct ttgttaatta agtcattaat atcatttaat ttagtgtaaa ttaatttaaa 1200 atcttcatat agttttttaa aattagcttt tgtgtcatta ttaactaatt tttgaatatc 1260 attttcaagc tcaacaatgt ttttatttaa tccagatgtt ttaattaggc ttttaatttt 1320 attagctaaa tctaaaattg ttttttgaat taaagctttg gtgtctaatc ttttttgatg 1380 agcatcagat tttagtttat caattattgt agtatcaaca cttgcttgat taagtaattt 1440 ttcatattga tttaaaaaat cttgtaattg ttttttagtg ttttctaatt caacaacatc 1500 tattaaatca ctcatgtttt tgattgaatc taattcattt aaaacactaa cttgtgtaat 1560 taaattttta attgtttgtt gttcttgttt taatttttgc tctgataatt tattaatgtt 1620 ttctaaattt gatttaagag tttgattata tatcttttta aaatcttcat aagatgattg 1680 atcaactatt tcttttaata aaacagcttt atttaaactt gattgtaatt cttctttagc 1740 tttttgtttt gtatcaactt ttgcacaagt tgtaattatt gttgctaaca aaggtatagc 1800 actaatcata cttagtttca atcaaattga tttgtatttt ttgtgtttca t 1851 145 2478 DNA Ureaplasma urealyticum 145 ttaaagtaag aaatctaata aatgtttaat gtcaataata aattttgctt tattcgcaac 60 tagttgttct ggagttttgt taatacttgt cttttttaaa agatcaaaat taactttttt 120 atttaaaaca tcatttgaac tagctccata aaaataaaaa tctttttgat ttttcatatt 180 aatataacaa actaaaatcg taatttctgc tttgtctaat tcatctaata ttaaattatc 240 gttattgttt ttattttcaa tatatcgttg atatgattca attaataatt ttgttttttc 300 ataatcataa tcactatata aattttttac ttcaatatat aaataatgat ctttttgatc 360 atgtgttttt atttttaaaa taaaatcagg gtatgaatta cttatttgac catcttcatt 420 aaaatattga tattttaatc catgaaaaac aggattttta gtccaaagtt caacattatt 480 tttaatttta tcattatcat ttgataatga aaggaaacga tttgcaaatt tagattcagt 540 taaagaatca aaatagtgat tttgttcttt aagatcttta tatgcatact tatcacaaac 600 atttaaatct aacatgtttt cacatttttt atatttttca atgggaataa aaatttcatt 660 ttgattaggt aaatttttat tattttgcaa tttaaaaagt aattcatgat tatctttttt 720 catttgttct aatgaatttt tatatatttt ttcaatttga tcaagatatt ctttaataat 780 aacatatcaa tacatgttga tgcttatgtt taattttcat cttttttctc actcattaaa 840 cttcgtttca agaaaatcaa taattttttg aggaaataga tgtttgtatt ttcttaattg 900 ttcaataata taaagttcaa gttcgattga atttttaatt ttagtataaa cacgtgtttt 960 accttcaatt tttgaagttt cgccttctaa gtattgattt tttacaaaat tttcacgata 1020 ttcctcatta acatagtatt caaaattact aattgaatct tcaaacttct ctactatttc 1080 ttctttataa gtttctccat ttaaatagtt attaattttc tcttgattaa tttcgccata 1140 aaaaaatcta tcatttttat atttgtcttt taaaatcaaa gtttgacgaa ttttatcttc 1200 tgaaataata ttagaataaa taaaatattg atttgatatg gaattatagc taatttcgtt 1260 tttgtcaaag ctaggatttg gaaaacgctt aattcttcca attgtttgta ctgataaatt 1320 ttttgaagaa acgtttcgca attgtactaa catgcaagca cgcggaatat ttcaaccagt 1380 tgcaggacca attttaaaca aaattacatc cacatttgaa gtctttttag aaatttcttt 1440 tagagaaatt ttattatttt ttttattaat taaaatatta gtttgaacct ctttatcatt 1500 agaaaagtat ttaactcatg ataaattatg tttttctaaa attttaataa ttttttcaat 1560 tttatctaaa aattcgcttt tttgtggttc tttattaggt tcattttcaa cttgaattaa 1620 catggctgga cgaatatttt ttaactcttt tgcttttgaa tattgctctt tgatttttaa 1680 aaattgctca caagcagttg ttaataatag ttcatcatca atgttttctt cttttagttc 1740 tttaatttct agattataaa catgttcatc ttttaacaat tttgtatcat catccattaa 1800 atctttttca tcaatgaata ctaatttatg aattccttta ggagttgctg tcattttaat 1860 aataaaagat gctgcttctt gaattttata ttcaaatcgt gtttcttctt ttttaaaaga 1920 atttttgtgt attttttcat caaaatcttc aaatattttt gttttattaa cattaccgcc 1980 atgatgagct tcatcacgga tataaactaa tgtatatcct tgtgatttaa tttcatctaa 2040 aaaagcatct aaaattcctt cttctgtaat aattcttcct ttaccaaatg aagaagaccc 2100 aaaaataatt actttatttt cttcagctaa aatattgtaa gaactatctt ttttagcact 2160 tttagaagat ggtgattctt taagttcgac atcaaataaa ccattaatat aatatttata 2220 ctcattcata ttttgttcta attgaaatgg taaatcagct gatgataaag tcgcaattac 2280 aaaaattaat ttttgaggac taccattagc tttgtttgtc ttaataattt cattaatagt 2340 attggtaata ataaaggttt taccagatcc tgttggtgct tgaaaatcaa taatttcttt 2400 tttattgtta ttcacgcttt ctaaataaca attaactaat tgactaacag ctttttgttg 2460 tgatttggtt aatttcat 2478 146 351 DNA Ureaplasma urealyticum 146 ctagtctctc tctctctctc tctctaacac taataaattc tttagtacat catagttttc 60 accaatgatt aaactattag tatcattttt aaataaatta tgtgcatcat tcatgaaaga 120 taattgctca tttttagcta atatcgcaat ttgagtttgg tgcacgcttg gagcaacatc 180 aaaactaaat cctattttaa cacgttgaat taataattga aacacattat ctaaatcctg 240 gggatcagtt ttttctaaaa tttttttaat taattgtttt tgatcctcat ttaatgaact 300 cttactcatt tcatcaatgt cttttaaata actatttaaa tctttaatca t 351 147 3078 DNA Ureaplasma urealyticum 147 ttaattagtt gttgtaaatg aataatcatt gtgttgagga ttatcttttt ttgcttgatt 60 acggttataa atttcgttat tgttattagc aaaatttcat ttataagtta aataatttgg 120 cttttcacta aagtaaatac gattgatata gtattttgta ttcggttcta aattattaat 180 tttattttct gatattaatc atgatgttaa acctgtttgt aattcttgat gtttattagg 240 gtcaatatga tttttaatta atccatcaaa ttctttatct gttttcgaaa gtgtgatttg 300 ataaggtcct ttaatatttc ctttatcatc aattaattct aaattagcaa ctaaaccatc 360 atgaaaagct tggtcgtggg aaattaattc taaattaaga ttaacttggg ttggtgaaat 420 gtttttaata tacttatttt ctttattttc attaaaatca cttgcagttg ttaaaatcgt 480 gttttgactt ggacgacaac gaattgttat agagctttga ttaaaaattg ttcaagtatt 540 atcatcgttt aaaacttcta ttcgttcaaa attatattct cgattagcaa ttggtaatgg 600 aattttaaca tacatacggt tttttaattt aaataaaaga ttttctctat taattatttg 660 atcactacta ccaatatcat tgctataagc cataaactct ttttttgtgc catcaactgt 720 tgtataagaa aaaacaaaac gtgctttttt atttactaat caaggatatt taacatttaa 780 aataaataat ttcacttcac aaactggatg attagttttt ttatcaacat caagtgtgtt 840 ttttagatat ttttccacca aagctattga taaaggattt tgtaattcaa aattataagt 900 aatttgattt aatttatgtt tttcatctaa attatttgga ttatttttat ctaaataata 960 aatattatct agttcatata atgtagcagt tttaatgtca tcaaacttta aattaaattc 1020 gatcattcac ttatttattt catttttaat tggtgtacaa ctaatagcgt tagttttaat 1080 ttttttgaca atcttgttgt ctttgtattt aaaagttgca gcaaatgtaa ggttttttag 1140 aatattagag ttggctttta attcaacttt taatttaata ttagcttcat ttttacgttg 1200 aaaataatct tcttggtttt ctaatggtaa taatgcaaaa ttattattga ttgtcaaagg 1260 ttgatttttt tcttcttttg tatcatcata aataatatta gtatctaaat aaccaatatt 1320 tacaattgct ttaggcggct tttgatcaaa ttcaatttta ttaataaaag atgttttatt 1380 taattctaaa ttatctaatc gagctgttaa atatttttta ttattttcag ccactacatg 1440 agcttttgta attttattat catcataatt aatagttgca ctcatatttg tatttaaaac 1500 attggcttca tcactaattt caaactttat atttgttgaa ttaatactat ttggtgatcg 1560 cggttcttca actagtgaac ttgttaaaac tttaactaag ggttttttaa taatcacttt 1620 gttaatttct aaaatatcat ctaaattcgc aatattgtta ttgactgtta gtttattatc 1680 aacaattcca attaatgtat atttatgatt tggcgcaaat aaagtattat catttgtctt 1740 tagtgttatt tttttattaa catctactat tgcttgtatt gtttttattt cattggtatt 1800 atcaattttg aatctaagtt caatcttttt attaattaaa tttgcatcgt taaaatttat 1860 tgtataatcc ccgtttttta aataattaac cactatattt ggtctattaa gagtttgttt 1920 ttgattgcta gataaatcaa aattgtgtac gaattcaata ttttcatcac tagcagaaac 1980 aattttttct aatcgatact ggtttggttt tactaatttt ccaatatcaa aacaaatctg 2040 accatcatta tcaactttag ctaataattt atgtaattta tgattttgat ctttaaaaat 2100 cccatatact tgttggttaa cataatatgg cgctacttta gcaattaaat taatatcacc 2160 attttttgta tactgatatg gttggtttaa actattaaca tttaaattgt taatagtttt 2220 attatgatat gcgatattaa ctggattaat aactttaact aaaggatgcg tgttattttt 2280 ataaatgtta actaattcat agaagttatt atttgctaat ttacttacat caaaatcaac 2340 atttccttct acatctactt tagcatcaat actataaatt tgattattta aatcttttag 2400 ttgcaaacta agagaagaat taaataatca ctttcctaca tttattcggt atattttttg 2460 attattttgg ttaataaaag aagctgtttt aggtggttta ctaatcataa tttgatgttc 2520 aatcgctaac tcattttgtt gaattaaaac gtgattgtaa tcagttttgt caagaatttt 2580 tactaaacga taatcatgat tatttgctaa ttttgatgta ttaaaataag caactttatc 2640 tttaatagtt ggttgtatgt aatgatattg atgcttttca tcaacaaaaa cacccataat 2700 ttgcggattc tttttagctt tgttttttaa attaacttta ataacaatat caccagtatt 2760 tgaatattca ttggttttat ctatcttaga taaagttaaa ccaattatgg aattagacaa 2820 tttatttttt tgtaatcgat aaacattacc ctgtggtaaa tgggtattaa tctcggtttt 2880 aagatctttt ttattatgaa tttttaatca ataggaatca ttattttgat ctacaaaaat 2940 aattgaattc tccttatcat aaagtcttaa aacaattcca actatgacag ctgatcaaca 3000 tagatttaaa catattaaaa aagaagcaat tttaatatgc ttttttcaaa gtattttctt 3060 attatttttc attttcat 3078 148 3057 DNA Ureaplasma urealyticum 148 ttacaatcaa attatttttg tttttttatc atttgggact aatgcaattt ttgcattatc 60 ttttttatca tttgctcttc aatatttaat accataaaat tgatatcttg aagattttgg 120 cattttatct aaaagtagtt gaaattggcc aggagtatta taatttttgt taacattatt 180 ttcaattatt ccaactgttg tattataaat ttgaccatta tctaaatttt tgtacataac 240 ttcaccaaaa atagaatcat tttgattatt catattatta aaaataagtt ttctaacact 300 tccactaaaa ctaacataag tataacttgt attatttgta gtataaatgt tatgatcaac 360 attcgtaata tctactattc cagcataatt acttgtatta gaacttttgt atataactga 420 accattttta ttagtatcat aaaaaatatt atctcaatca ttatttatgt ttttatatag 480 gtaagaattt ggtttatttt caaattttac aattcttaat ttatattcat tattttgatc 540 atttatatta atattgttaa tatgaatttg taatttaggt ttaccattgt catttacaat 600 tttaattatt ggattatcat caattttatt ggttgataaa ttttccacaa tagcacgaat 660 tttatatgaa tttaataatg attgagaaaa tcactcatca tcattagtaa tattaaattc 720 cattattctt gatcaaattt gttttttttc atcaaaattt gtaatatttt taaaattagt 780 taattttgtc acacttggtt caacaacaaa tgttttatca tttaatttac taatatctat 840 tgaagtaata ttattagtat tatgatttat tttaataata ttttttaaag tatattcacg 900 attataagtt aaattttcaa tattaacgct ataatcttct tgatttttat ttaaagttaa 960 gcttacttct tttttagaag ttgaattatt gtatctatac tctaatacta atctatcacc 1020 atcattgtaa tcttttatat ccttaatttt taatttaata attcttcttc ttaaatcatt 1080 agttttttca taagtaattg attcgatata tggatcaata cctttagtta aaattttatt 1140 ttgattttgt tcaataatgt taatgtttgt gtttaattct gtatcaaata gatcattgcc 1200 tgttggtctt gataatttta ttgtagataa aatgtattct gtatttggct ctaaattaga 1260 tatttctcct tcaagaatcc atttattatc ttttcttact aaattaattg tttgtataaa 1320 tgtcttggta ctatcactaa cttttttaaa taccaattgg aatttagaat ttgtatttaa 1380 cattgttcca tcattagtag ttgtaatttc aaaagcatac tttgcactat taattgttgg 1440 ttgatcccaa tttccgtatt tttttgcatt atatattgct caatttgttt taaaattagt 1500 attctctaac gttcttcttt gtgcatcatt aattggtgaa ataattttat taccatttac 1560 atcttcataa gctttgtttg gttttttaat cattcttatt tcttttatgt aatattcact 1620 tccttcatca agatttacta aatcatgttt aatatttgcg tataatccat catttcttga 1680 atcaatgatt gacattgtat aaactttcat tttatcttga ttgtttggat attttttatt 1740 agcaaaagtt acaactatct tatcgccatt ttctaaaatt ttatctaatg attctaaacc 1800 taatctaaat ttagcagtag ttatgccaat atttgatttt cacaattgat tttcatcgcc 1860 ttctgtttta aatgttactg cagttggtgc atgatgatat ataaatgaat cagcaatatt 1920 atttgaattt agcaattctt caaagatatt attatttgaa attaaaatct ttttgaaaga 1980 atattttcta ttaggagtta gtttactaat atcaaaatta taactagttt tattgtttga 2040 taaagttagt tcattagttt ctcattcttg atgattgtta tcttcatata ctaatttaat 2100 ttttttgtta atgtaattag aattaattct tgaaaattct gcttttattg ttcctatcac 2160 tctattagga ttaacagcat tttcttgtat attgtaataa atatcattat ttgattctaa 2220 tttcaataat tttagtttat caactaatgt tttgaattta gtatctagat tacctccata 2280 tattacatta tttttattta ttgttaacat tcatttagct aaatctggct tatttttaaa 2340 tttagctgat gtgaatctat attctgtttc tggttttaaa tcagttaaat ttcatttaat 2400 tttagcacta tttttatttg cacttacttc acttaataca ccatcaattt ttttaatttc 2460 tgatggattt gatgtagata caaatgtagc ttcaacaatt tgattatttt caaaaacttg 2520 atcagttgaa ttaactttta catttatagt agcactattc tcagttaaat ttgttaccca 2580 attagaataa tcgatagata aatttgtatt ataaggatta ataccaaatt tatgactaac 2640 accattaata cttaaatcat taaacactgt attagtatct tttgaatcag taatttgagc 2700 tttaaataat ttatattcac gattagtaat caaatcctta tcaagaacta aatcgtaaat 2760 ctttttatta ttttccaatg taacttcttt tgttcaaaca atttgctcat tattatcctt 2820 ataagctaat ttaatttttc taccagcata attatcatta acaccagaaa cggttaattt 2880 aattgtttgg gttgtattat taatattatc gtttgaagta atatttacaa tagttgttgg 2940 tcctgatatc gttctgaatt tataattttc attattatta ataataatat ttccaggtaa 3000 taaattttca tatgctaaac gtggtttttg aacaaattca acttttaata atttata 3057 149 14066 DNA Ureaplasma urealyticum 149 ttagtttcaa atatttgatt caacagattt taattttata tttaactcag cactattata 60 cgtaatattt aatggagtgc tccattcgat gcttgttgtt gatgggtttc gtttaaaact 120 attatttaca gtattttgtt tttttaaatc aatatattga gaattatttt tatcatcatt 180 aatttgtatt ttaataaaag tgtaatttct attagctatc agaccactta gagtaaaatt 240 atatttttgc ataccttttt ttaaattaac tatattgctt tcatataatt cgttattttg 300 atcacgataa attaatttta ctcgacgccc attatattga tcatttactc cagaaaatgt 360 tgcattaatt gtttgagaat caacattaat ttcatttgtt gataacaatt catttaaaat 420 tgaaggccca aattgggttg taaatgaaat atttctttta ttttcaatag aaacatctaa 480 atcttcataa acattgcttg gttttgtaat attaattgaa tttaatacgt atgttgaatt 540 tggttctaaa ttatttattt tacctttaat taatcatttc ccattttctt ttaataagtt 600 aacatttact tgttttaaag taccaccatt tttattaaat gttaccgttg ctgttgcatt 660 tgcatctaat tctccatcat tatcatctgt ttttagaaga aaattaaatt cagcacttgt 720 atctgaagga tttgatcatt cgccattttt agaaattata gtgtgtgatt tgtttatttt 780 aatttgataa ttaatgttat ttaattttgg taatttatta ctttcaacaa ttgtatttga 840 attattattt actaaataat acacatcaac taatgaatat aacttattag cttttaaatt 900 atttaaagta aatctaattg atgtctttcc gtcattattt actaaagatg acccattaat 960 aacattagtt tcaataatat cattatttgt tgatttgaat ttagctataa atcttaaatt 1020 atgtgctatt ttaggattaa tttgcaatcc aagatctaca tcgatattgt ttttttgatt 1080 agcgttttta acaactattt ctttatttat tggaccatta acaataatat cgttattaat 1140 ttctaattta ggtattgaat cattattata aatgatatta ttagatttat caattccaat 1200 attttcagct gctatacttg gtttattatt aaaactaata tttactatat ttactttatc 1260 attaaaattt aaatcaacta aagtagcagt taaatatttg atattaccac ttacagtaat 1320 aaatcccatt gcttgtttat tattaccata aacaatagta gcttgatctt tatctctaag 1380 tacattatct ggatcgttta aattaatttt aataatagta gattttaaat tagttgaggc 1440 tcgattacta atttcttcaa tattcaatac atttatggcg cttgttcttg ttgtaataaa 1500 actatttgtt aaattacctt cttttgggaa atctgaaaca ttattattat caatcaattt 1560 tacatcaatt aaggtatatg tccgattacg ttttaaatta tttaacaata tattatattg 1620 tgttttatta gattcaatta atacctcatt agtatgaatt gattcactag tatcatttga 1680 tttataactt agttttattt tctttccaac tcatgatttt ttaactccac taagtgtaaa 1740 attaattgtt tgcgaatttg tgttaacgtt attacttgat gtaatattta ttaatttgtg 1800 gtcgccaact ttcgttgtaa attcataatt tgaattaata gaatttgtgt tatctaaaat 1860 aacattattt tcactattat tgatattatt tttggctttt gttggtttgt taacaaattg 1920 gattttaact aatttataag ttgtttcttc tttaaaatta acactattac ttaaatcatg 1980 cgctcaagtt ccttctttga aatcactagt tacatctttt aatggtcttg tgtattgtaa 2040 ccatgtatta gtatctctaa ttgtttcttt aggagcaaat catgcaacta cttgttgatt 2100 attttctaaa attttatctt ctgatttaat tttgaaatta aaattaacac cacgcgtccc 2160 aacaattgta gcactactat catttcattg aactgtagta ttttttgttt gagtaataaa 2220 tgtatttgac acaccattta atttttcaag atcttcaaaa ttattagtat tagaaatatg 2280 atttatttca attttttcaa acctatattc tcgatttgaa tttaaatttg ataacaataa 2340 ttgatagtca tttttacctt tttgtaatgt aattaaagaa ctttcataga taacattatt 2400 attatcttta taaactactt taatctgacg tccattatat ttagagttaa ctcctgataa 2460 cgttacatta atagtttgtt gagtatcatt aatagtatca ttttgagttt gaataacttt 2520 taaaaccgga tttccagttt cagtaattaa acttatattt tctttatcat taatcgatac 2580 agataaatta gtgtgagttt ttaatggttt acttaattca atattttcta atttatattt 2640 agtttctgga tttaaattat cgatttgacc tttgattaat caatcattat tttctttaat 2700 tatacgaact attttttgct taatattatt atgttcatct ttaaatttaa cagttgcatc 2760 aatgttattt aaaacatcat tatcatcttg agtttcaatt ttaaattcaa aattagctgt 2820 tgtatctgta ggtgattttc aatttccatg tttactaatc attgtaacac ctggattaat 2880 ttcaatttcc ttagatacat tatggtcttt aaatattttt cttgtttcat caatattttg 2940 atgaatatta tctaaataat aaacatcaac taatttatat aattgatttg attttaaccc 3000 cttaacacta aaaagaactt cttgtttgcc tgttttatta atattattac catcaattaa 3060 ttcgctatat acttcatgac caaattcatt tctaaattta agcttaaatt taagattttt 3120 agctatatgt ttgtttattg taaattcaat tgatgaatta atgctttctt tatcattata 3180 atttttaatt tcaagatgta aattattaga tgataatgga ccacttattc taaaatcatt 3240 gttaattttt aattttctag tttcttctat taaatttgtt aattcataaa ttttattcga 3300 attattaatg ccaacactat caactgcctt attaggacga gttataaatt caattttatt 3360 gataattgta tcatgattaa attcaagatt agataaacta acttctaggt atttctcatt 3420 atttactgta ataacttttg catttgtttt tttatttgta tcatatgtta tttcagcaat 3480 ttcgttgtta cttaatacat cctcaggatc atttaatgaa aattgaattt ttgctacatt 3540 taaattattt attactcgat cactaatctc atttagctta ttgacactaa ttggtgtttt 3600 tcctttaata ataaatgaat tttgaagatt ttgcttattt ggaaaatcaa ttcaattttg 3660 accatcaaat cattttatgg atttcaaagt atatttgcga ttgtatttta aattattaaa 3720 attaaaaaca taatttaatt tattttcctc taaattaact ttcgcctcta cttcatcatt 3780 tgtattagat atatatacta atttagcttc tttgttaaat cattcactac gaattccatc 3840 aattgtaaca tttacatttt gcgaatttgt tagtgtttga tttgattcaa tatttataat 3900 tccataatta ccaggttttg ttttaaatga aatattagtt ggattaatag ttttaagatt 3960 agagttagca tttagtggct tagttaatac aatagacttt aactcatact ctgtttctgg 4020 ttttaaatta tttactatac cttcaataaa ccaaatgttt ccttcttttt ttaattttac 4080 attgttaaca aattttgtat cattttgatt tgattttgat gaaaagataa catcagccat 4140 aacattatta tctaatatgt cttcatcatc agattcaact tgtaatttaa aatttacact 4200 gtttgaattg atctgccatt caacattatt ttttttaaaa gttgtattac cgggtttaac 4260 ttcaatttca ttaacaacat tattagatct tattaattta ttattatcta taagatcttt 4320 atcgtcttga tttaataaat aatataaatt atcaaagtga tataaacgat ttgattttag 4380 atttggaatt ctaagttcaa taatttgttt tttaccttct tttttgattg aactataaga 4440 aacaatactt gattttacgg tttcattatt ttgatcttta aatgttgcta taaagtataa 4500 attttgcaaa atattatcat tagcttttaa ttctaaatta acttttacat tagttttatt 4560 attatattcc aaagtaatac gtttattagt atcactttga acaggaccaa tgacactaaa 4620 attattatca atttttaatg gatttatatt gtttgtattg ttatatattt tattgctatt 4680 atctattcca atattcgtag cagcttttat tggtttatta ataaaagtaa tactgttaat 4740 aatagtatct tggtttaatg ctagattatt gaatgttgtt tctaaatatt tttgactccc 4800 tacaatttta acttttgctt ttacagataa attctcacca taattaatga ttgcttcttc 4860 ttcattactt aaaacattat caggatcatt taatataaat ctaatttgtg ttgattgtaa 4920 attatttttc gctcttgcaa ttggctcaat tattgaactt atactaatcg attgtgtttt 4980 attaacaata aatcaatcag ctattccatt ttttaaatgg aaaattattg atgttttatt 5040 atcatcatta ataattctta cttcttttag tgtatattta cgattatgtt ttaaattaga 5100 caattcgaaa ctatagtggt tattagccca aagcaatgtt ttttgatcac ttaaaatttc 5160 ttcaccgtca tttgaagtat ataccaattg aattttttta ttaattcaag ttcgttgaat 5220 tccatcaata tcaatattaa ctgtttgtgt tgtagtattt atagaatcat tagaactaac 5280 atttgttact ttatgatcaa caattaaggt tttaaaatta taattcgaat tattgtcttc 5340 aaaaatgaca ttattagcat cattattaat attagtgtaa gctaatgttg gttttctaac 5400 aaagccaact tttattagtt tataatttgc ttcttctttt agtgtttgat cagtattaaa 5460 actaactgtt gcctcacttc catcactact tatacttgtg atagtttttg tatatgatat 5520 ttcttgacgt tcatcatcat tagatttcaa ataagtaata atgctatcac ctacttgaaa 5580 tacgtgatct ttagatttta atttatatgt aattgttgca cttgtgcttg ttatatttgt 5640 tgctaaatta gtattatcaa tgactatttg tgtctttgat gcatttacat taaaactatt 5700 cgtaacattt gttgaattat taagtgtttc aaaattatta ttagaagtct ttatttttat 5760 ttctttaaaa gaatattgac gattagcaac actaattggc agtgtaaaaa tatattgtgt 5820 ttgatctttt tgaagagtta gttcatttga ttcaactaaa cttttttgat tattacttct 5880 atattcatag actaacttaa tcttacgatt attatataaa tcattaaccc ctgatacttt 5940 agcggtaatt gtttgttgat ttgatgcatt aggttgatca tttcacatta aatcatgaga 6000 tgtaatgcta actaattgtg ttggtccact ttgagttgta aaactaattt gttctttatt 6060 ttcaatttgg atttttaaat tagcaaaagc attcattggt ttagtaattg agatgtcatc 6120 taatttgtat gtatcattat aagccaaatc actaatagta tcttcaatat accattgatt 6180 atctttttgt tttagttttg ttgtaattgt ttttttagta tcatgttggt cactaaaagt 6240 gatagttgca tctagatcag tactaaaatc aacattttca tctgaattaa tattaaactt 6300 aaatttttga gcatttggtt gtgggaatgt tcaattacca tttttttgaa tcgtagtaat 6360 cgttggttta acagttattt tataatcaac gtttgaattc ttttcaaatt tattattttc 6420 atcaatatta gtttgatttg atgaatttac ataatatagt cctttgaaaa tatattgacg 6480 atttgatgtt aaattagtta aattaaatgt taattctttt ttattattgt tattatttgt 6540 aacaatttta tctgcagcaa ttgggtttgt taaaacactc tgaccatcgt tactgtcaaa 6600 ttttgcaata aaatataagt ttttactaat atgattattt gtatctaatt ctaatgaaac 6660 tgaaatattt gttttattat tagcttcaaa ctcttttagt gtatgaagtg ggccagtgat 6720 ttttaaatca ttattaatta ttaaattagt agcatcataa ataacattag tatcattaat 6780 accaatattc ttacttgcat ttttaggttt tgtattaaat tcaattttat taatgatagt 6840 atctttgttt aagactaaat tactaaaagt tgcttctaaa tatttttgat tttgatcagt 6900 aattactttt gcactagtag tttgattatt attataagta atagttgctt gttcatcatt 6960 acttaaaaca ttatctaaat catttaattc aaaccgaatt tttgcactat ttaaatgatt 7020 tacatctcta tcttgaattt caataatatt accaactcca acttggttat tacttaaaac 7080 aataaattta tcttgaatcg aatcactttt attaaatggt gttttagtgt tattatcatt 7140 aattaattca attttagtaa atgtataagt tcggtttttc tctaaattag ttaattcaaa 7200 ctcatattct aatttatttt tttctaattt aattatagcg gtttttgttg agttatcgtt 7260 tgcactataa gttatttcta attgtttttc atttcatgca ttttgtatac catcaagttt 7320 taacttaatt ctttgttttg tatctactgt tgatggattt tgtgatttaa tttgaataac 7380 tttataatta ccagcttgcg tttgaaatga aatatcgtct ttatttaata tttcaactac 7440 taatggcttc tttgttttat ttggtttagc taatagaatt gattcaagta catacctgtt 7500 ttctggttct aaattagtaa tttgaccctt aattaaatat ttattattct gcttaataat 7560 attaacttta actggtgtta gtagagtttg acctttttta aaactaattg ttgcttctaa 7620 attatctaaa acttcattac catcatcact attaattaca aactcaaatt gtgaacttgt 7680 tgatgtagta tttcaagtat tatttgattt gctaattgtt gttttaccag gtgcaatgtc 7740 aattattcga gtaacattat ttgcttttgg tactttgttt ttgtcattaa tagtatcatt 7800 attatcatca atataataaa catcaactaa tctatataat tgatttgatt ttaaattatc 7860 taaagtaaaa ttaattacgt ttttattgtt attaactata attgaactat tagttaaaat 7920 tggactataa acaacttcac cattgatatt ttgaaattta agtttaaatt tcaaattctt 7980 actaatatgt ggattaactt taaaatctag tgttgaagaa attacgtgtt tattattagc 8040 cactatattt tgtgtactat taacatcagt tgataatgga ccaatgattt ggaaatcatt 8100 attaataatt aatttattta aattactttc gtcataaatt acatttgtat tatttttgcc 8160 aactttaata aaggtttgag ataaattttt aaattcaatt tttttaataa ttacattttt 8220 attaaatacc aaatttgtta ttattgcttc taaatatttt tgattttgtg cattagtttt 8280 tacaatagca tcaacttttt gttcgttatc ataagtaatt gttgcaatat catttgtttt 8340 taaaatatca ttgtcatctt ttaaattaat tttaatagtt gtttgattta atttatcagg 8400 agcacgatca ttaatttctt ctacgcttga tgctgtaatt tcgctttgta aattaacatc 8460 aaatgaatta tttacattga tttcttttac aaattcgtga tcttggccat tgtcaacttc 8520 tttaatatta attttcttta aactataacg tcgacctggt tttaaattat ttaatactaa 8580 attatattct tttttatcaa aacttagatg aacactattg ttgttattat caactgttgt 8640 tttaatttca ggatcaccta aaatgtttga ttcataaact aattcaagct ttttattatt 8700 tcaagctcgc tgaataccat caattttaac agtaatttct tgttgtgttg tatttgttga 8760 tgtgcttgac actacatcaa taactttatg ttcaaatttt tgtgtcgtga attcatatgc 8820 ttgtgaacca tttttatact caaaaataac accattttta tttaataact catatgcttt 8880 atttggttta tttttaaatg ttactttgat taaacgatat gtcgtttctt ctcttaaacc 8940 gcttaaatta aattctaatt caccttcatt aaatgaatta gttacattat ttaattttgc 9000 ttcaactact ttttgatcat ttaaattatt agttggagca aaaactgctt cgacaatttg 9060 atcgttttct aatgcttcat catttgtttt aagcttaaaa tgtacttgag cattatgtgc 9120 actaactgtt ttaatagcat tattagtatc ataattaatt gttgttaatg atggttcaaa 9180 ttcaattttt ggtttatgaa tctttgaatt aaaactaatt tgattatttg tcatatcatt 9240 cactgaattt tgatcatcaa aataatacaa accttctatt cataagcacg attatgaatt 9300 aaattagaaa gtttaaaact aattttagca ttattattga ataagatcgg atcagttcaa 9360 acagttttat tatcgtttaa ctgctttaat tttaaacgta aatattggtt tgctaataat 9420 tgtttatcaa cttgaagatc aacatcaata tttactgatt tatcattctt gttaattgtt 9480 tggggtttat aagatgttgg attaatatta tttgataaac taattttatt ttgttcatca 9540 tatgaataaa caatgttatt agttttatta ttagtaaaat taaaatatgc attagttggt 9600 tttgaattaa aactaatttc tttaataaca taattttgat taatttttaa actaactaaa 9660 tcgaatttta aaaatttttt attgttttct acaacaactt gggcattagt tgctaatttt 9720 aaattattat tggcatcatt actattttct aattgataaa caatatttgg tttatcagct 9780 gtatttaaaa cattatcaat gtcatcaact tcaatctttg ctgaaattaa tgattggtca 9840 ttattaacta atatacgttt tgtgatttca atattagtgt tattttttaa agaaactgca 9900 ttattacttg gattaatgct aaattgatga gttaacgtgt ctaacttatg taatgtttga 9960 ttattagttt cataaacaat tttagaaaaa gtatataaac gattcttaat taaatttgaa 10020 aattcgaatt gataatttct ttgtcctttg attaaagtaa ctgcttttga tttaatctct 10080 ttgttatcat ttgatacata aattaattta acttgttgat tatcttgaaa atcatcacct 10140 atattaattt tggcatttat tataggagtt tgatcattat ttcaattatc aattgaattt 10200 agacccacta gtgttgtgtt tttattagat gtactaaaat tagtatttgg atctagtaaa 10260 tcaaattcac tattaacaat actgcttgca ctcttattta aagcttcaag ttttttaata 10320 acatatgttg ttttttcttt taaaccaacc aaattgaatt taattttatt atttgcaaca 10380 acttttccat atccaatttg tagttcgttt ttagtgttat caatattttg ataataaatt 10440 ttaacatctt cattaattcg taatttttga tcataatctt tataatcaat aaataaatta 10500 gcatggtctg caaaaatatc ttgttctaca gcgcttttat taaatgataa attgatctta 10560 tgagggtttg taataaaatg ttgttcatat tttgtaacat catttttaaa taaatacacc 10620 ttttggtttt ggtcatttaa ataatataag tttttaatac tatatttact atttcctttt 10680 aaatcaagac cattaattga agcgatttta ttagttttac taaaattaac taaagggtta 10740 ataacatctg tatctaataa atcatcatcc attaaagcta actgtgcata gattttttga 10800 tcatttttta aaatattatc tttatcatca atttcaaagg tgatagttgt atcattatta 10860 gttttaacaa ccacatcaaa tttagttcaa attggtggat taatagtagt tgctgagctt 10920 gttgtgaatt caaaatttaa aacatcatct ttaattaatt ttattggttt ttctttgttg 10980 tttaattcta gtaattcaac atcaacaact ttatattttg tgtttgcatc taagtgtgta 11040 aaatcaaaat ttagtttata gttgttagtt tttggatcat aagttgcaat gtatttttgt 11100 gtatcattta aatcattaac tttagcaatt gttagtgcaa attgacgatt ataagatagt 11160 ttatttaaat caaataagtt tacttggaaa ttaatagcat ttactgttac gttagaaact 11220 gctggtgctt ttaaaacaag cttacgagct tgatcgacac catcattaat tgcactaaca 11280 tctttgttaa tactatttct atctaatatt gttttgtttg gatattcatt taaatctaca 11340 atcttatcaa aatcatagat tttgttagga tcaaataaat tattgtttgg attaacaata 11400 acttttccct tatcatcagt tttgattgga acatgaattt cattgttatt tttatcttta 11460 taaacagcag ttaaatcttt atttttttga tctggtattt taaactcatg cttattatca 11520 gcattaacat taccattttt ttgtttatta actattcgat ctaatggtga aatttcatca 11580 atattagcaa cttttttatt atcagcttca atttttgtta gtgtatattt atgatctggt 11640 gcaaaaattg catcatcact tgttttaaaa atagcttttc catctaaacc aatactagct 11700 tcaaccgttt ttgtattagt attattatca tcggttttaa atgttaattt aattttttta 11760 tttgctaaac taggatttga aaaactaatt tcataatcat cattttcttt agttttagca 11820 gttattgttg gttttttaaa tgaaatatga ttatcaccac ttaattgctc ttcactaatt 11880 agatcaatat ttggttgatt attttgtttt aaaacgactt ttttaagtgt gtatatatta 11940 ggtttagttg ggtcattatt tgctaaattt tttgttggaa taataacctt gccattagca 12000 tcaatactta catctatctc atgttctata ccatcttgat caacaacaat tcctttgaca 12060 tttgcattat ttaaagcttt ttgttttaaa tcatcattta aatcatttgc taattgagtg 12120 tgaatttcta aatttccatc attatcgtac gtaaaatctg gatgtgaatc taataaattc 12180 aaatctcgtt tatcaattat tttatctttt agttcaaaat cattaagatt aatgacttta 12240 tttaaatcgt tattttcaac tttagctaaa tgataaatat atccttttgg taaatcatta 12300 ctatcaaaaa taattttatt attttgatcc acattagcaa ctactttata ttctttatca 12360 ttattatcaa caaaagttgc tactaatttc tgattaatta aatcattatt taaattttct 12420 aaaatttggg tttttttagt tgaatcaaca cttgcattag cagctggctt tttaattaat 12480 tgtttttgtt ttgaagttaa atcaaaattt gaaaccaaaa cattttgtgg gtttgaaact 12540 gaaacaattt tgtctagtga ataattactg ttattattta atgcacctgt atcaaatgct 12600 atggttccat cttttttaac ttttgctaaa atttggtgtt cttgattatt ttgatcttta 12660 aaaattccat atacttgttg gttaacataa tatggcgcta ctttagcaat taaattaata 12720 tcaccatttt ttgtatattg atatggggta tttaatgcgt ttgaatttaa attattaatt 12780 gatcgattat ggtatggaat ctgtttaaga ttaacaacat caacttcatt agttttttta 12840 ataccaataa cttcatataa attattatca cctaaagatg aaatatcaaa aacagctcgt 12900 cctttttcat ctgtttttgc attaatttta tatgtttgat gatttagatc ttctaaggta 12960 agttcaagag gagtgttttt taattgaaca cctaaatcaa cttcatatac ttttttgtta 13020 tcaataaaat taactttagc ttttgttggt ttatttacac taactttatg ttcaagcatt 13080 aattcattat ttggcactaa aacatcattt aattcattat tgttaacaat tcggtttaat 13140 tcatatttgt gatttaaagg tagtttttta gtattaaaat acccaacatt attttttaca 13200 ctcaacgctg gtattaaata ttctttatta ttttcatctt taaaaactgc tgttggcaag 13260 gcttggtttt tagttttatt tgttaaatca acttttaaaa caagattacc ttcattatca 13320 taagtatgtg ttttatcaat ttttttaaac tgttcatcaa tatcattaac atttacaact 13380 tttgttaatg gatttgaatc ttttaaaatt agatctttta aataataaac attgccatct 13440 tttaaactac ttgtatcaat atcaattttt tgatctaatc caacatgtgc ttcaatacta 13500 taaacttcat tattttgatt tacaaatttt gcgactaaaa ttttattagc aagtatttta 13560 tttaccttta attgaatgtg cttttcgttt ttttgatcct catatacatt agttggaact 13620 ggttttaaaa cttcaatttt ctgttcaggt tttagcttct cattttcacg aacaatgtta 13680 ttatttaaat caataattcg atttagctta tatttacctg tttttggtaa atacttagta 13740 tcaaattcaa attttgcata agaatcaatt tgagttttta ttttatattc ttgattgttt 13800 tcatcaacaa aaacaccata aacatctttg ttaatataag tttttggtaa ttgaccttta 13860 atgattaagt caccatcatc attaaaacta taaaaatcat tattacttaa ttcattattg 13920 ttttttgaat gtaaaacaat cccaataatt gctcctgctc acgctaaatt tagcgttgca 13980 agcaataaga aaagacgttg cttacgactt tttttattat tatcgttttt tattgtttgg 14040 atttttttac tttttttatt attcat 14066 150 3312 DNA Ureaplasma urealyticum 150 ttagtttact ttaggaattt tatgaccatt aattttaata ctctttaaaa attgtgtaga 60 gatctgattt gaatcaagat ttgagcatat atcttttaaa tcatttaatc aataacaatt 120 ttcattagtt agtgtaattt caacactttt attattattt ttattaattt ttgcaactat 180 ttttgactct aaagtatccc catcgctatt gttatataca taatttaatt caatattaca 240 ttctttatct tgggataaat tacttaaaaa tatatcttga tcaaaagtaa tattaatttt 300 tggatcagat ccattaactt catatttaat attatctact tttcatttta aattgggatt 360 taagattcca ggaaaattaa aatagcgttg gttatctact caagttaaat ctaaattttt 420 atcattcaat tgaattgaat taattcgata tttaatatca ggctttaaat attttaattc 480 aaattcaatt gtttggtgct catagtcgat ttttaattgg ttatgagcat ttaaatcaat 540 acattcttgt tggttgtttt catcttctaa cactaatgac attttatggg cgtttttatc 600 tttaaagatg aaatcgctaa aatgcaactt gaatttaatg tttttttgtt gttggttaat 660 ttcatgatca attttatcta agtaaaattg atcaaagccg taatctaaag ttttaaaagt 720 cttattattg atatttttta aattaatctg ttgcttatca ataaaaagtt cactaatttc 780 ataatcagta ttaatgttta agttatctaa tttagttgag atttggtgtg tttttttatc 840 aaaataaaaa tctgttttaa ataaatacaa cagcttgttt gtttttttat tttttaaaat 900 aacatcaact ctttttggca tatttataac tgcttggttt agtgttaatt ttaaagtact 960 atttgtattt ttaatatcat taaattctaa atttaataat aaatgtggag atgattcatt 1020 aagtgtttta actgtaatat tattagttaa ataattgtca tcatctattt caaaagaaat 1080 aagtttaaat gtttgatttt tatctaaagc aaaaagatgt aaaataatgt tttttgttgc 1140 attaagttga gtagtttctg attttgataa gtttttaaca aacttatatt tattatgatt 1200 ttcatcttct aaagtatatt ttattttatg ctcaatacta tcagcatatt gattgtcttg 1260 taaatcaaca tttagatcgg ttgaagttga ttttgtattt gtgaatgaaa aaacagcttt 1320 tttgaactca tttgttttaa atttaagaaa tgaaagatcc aagtgaaatg gatgagaatc 1380 aaaaaaatct cctatataaa catttacatt aaaattatca ctatggtaat taccatcaac 1440 atcttctaag ataaaactta caaattcata attaatatga ttatctaaat ttaataattt 1500 aattttaatt gttttttgat cttcatcaat actcatgaag caatttttat cttcaaaact 1560 aaactcctta tatgctcatt catttggatt atttaatgga tgatatctta atttaatttt 1620 gggttttaaa gaattttctt ttcttaaaag taatttttca catttaatat taataatcgc 1680 actattttta gtaatatccg aaatgaaaag gtgttcttta taatcttttt ttacttcttt 1740 tgatctttca ttatcatctt ttttagaaac tgataaatat caaaaccaac tattaaaagc 1800 actatagtaa gaattataga atgatttatc tttaaaaatt tcaatacttg atcgatcagg 1860 acgtatttta aatgttttgt taataggtcc ataatatcca cctgcatagt catcatcatt 1920 agggaaagat actggtttac cgtttagtaa aatattatca atttcataag ttttgtcaac 1980 atctaaacca ttaattacag cagttaataa acgttcttgt tcatcgtatt taacttctga 2040 gaattcaatt gggttttgat cattttcttt tctaattaaa aatttaaaat tatgaatatt 2100 aggattgtag aaagcaagat cttcagataa ttttacttta attgtaactg cttttgtaat 2160 tttatcaaca gctgtttcat aatcaatagc ttcaacttta gcataatcgc cttttgttgt 2220 aaaatcatgt gtttgattat ttaaatttaa aacttgatca ttaatcttaa tttgtttaat 2280 atcataatga gttcctcttt ctaattcatc aacataaaca ataattctct tgtttaattt 2340 atcaataaaa aaatgcttct tattaagctc taattgacct tttttataaa ctctattata 2400 tgctaaacta atgtggatat tatttaaagc ttcatcacta tcatctttta tttttaactc 2460 tttaaaattt aaagttaaat tagcaccatt atcattaatc tttgtaattt ctagattttt 2520 taaaagatta tcactatcat caagggtttt aaaagtgtgg tttggaattg aagttaattg 2580 aattttttga ttattaaaat taagtttatc taataaatat tcacaatcag atgttaaatt 2640 ataaacggta gcatcaattt catttttttg cttattgaaa acagcatcac tagtaatgat 2700 ttggtgatta gtttttttga taatttttaa actaaaatta tgaatagcat cgtctttaaa 2760 agaaactgtt tttaacttaa tctttatatc aacttggttt tgtttaatat ttgtaaacga 2820 aatattatta atttctaaat gatcaatctt tggtgtatta ggaagtgatg gttgtaaatt 2880 taaatcttca ttaatatctt gttcgataaa atttaaatta tgatcaaaaa ttaaatgtag 2940 tgcaggaaat gcatcatttg aaaaattagt gataaaatga tcattaattt ttggtttacg 3000 agctagtctt aaataaattt tgttattaat aatcaaagga tgaatatttt ctaaacggtc 3060 aactttttta tttaacaatg gattaaaaag attggtgttt aaagttaaat tcttataaat 3120 accttgcgaa gtatttagtt cattaacttc ataaacaaca taataatggt cactcttggt 3180 atgaattata tctttcatta aaacattaac atttaacttt gatttattgc tacaagatgc 3240 aagtgctgta gcaacaatag gaactaaagc agctgtaaat aaaaataata actttttctt 3300 aattaatttc at 3312 151 2118 DNA Ureaplasma urealyticum 151 152 15016 DNA Ureaplasma urealyticum 152 153 2418 DNA Ureaplasma urealyticum 153 ttaattactt ttttgaccat catatttaag agcaattagt tgatatttat gatggttagg 60 taaaacctca tcactagtta taaatcgtgt ttgacctaat gaatcaataa tagtttttgc 120 tttaacatga tattcttttt gattttcatc aataaaagtt gcatctaatg aacgattaaa 180 caaattctta tcaaaagtta gtaggtttaa atttttattt gcatcttgtt taataattgc 240 aagtggttta ataatgctaa ttctgtttaa aggattaatt tcgtttgaat ttaataaaat 300 ttgctcatgc ttgtttttat caacaatatt taacaattga tagtggtggt ttgcatctaa 360 atcttttgtg ttaatactta ttttattctt atttaaatca actttagtag gaacaaaata 420 atctttatta ttttcatcaa taaaatgagc aacagcatct tgagttgtta ttttatttaa 480 attatcatta atgtcaataa ttaaatttcc taaatcatca taggtgtatg tatttaattg 540 ttgtaattta tttacatcga ctttttctaa taatctatct tttctatcta aatcattaac 600 attaacgatt ggttgattat taacattagt aattttagtc aatgtataag tgtgattatt 660 aggtagtaaa tgatcatcat ttgttcttaa aattaattct tgttgatcat ttaatttacc 720 agttaattga taaggatgat gattttcatc ttcaaaagtt aagacaacag acttattagc 780 taaatcaggg tttaaaagtt gaattttata attattatct tctaatgccc caacaatcgc 840 agctggttta ctaaactttg ttttttgatt aattgcaagt tcataatcat ttaaaacatt 900 tgtttctggc tcttctaaac taataacatg ttttagttta tatgtatgat ttaagtttaa 960 atcagaagtg ttaattacaa tattgccatt tagatcaacc tttgtcaaca ctttatgttc 1020 attatttttt tcatcaataa acacggcttc aacttgatca ttagcgaatt gtttagaatc 1080 tactttagca ttaaaaatta aattcccttt atcatcataa tgatatggat catttaatgc 1140 attagtgttt aatttattaa tagttttagc actttcattt aaatcatcta agttagcaac 1200 gcgttttgct ggagaggtat tattaatgct aatattatct agtttatata agtgtccatc 1260 ttttaaattg tttaaatcta cagtaatttc accattatta accttagcaa taatattggt 1320 tttatcgtgg ttttcgtttt caaaactaag tgttaataat cgatcattta aacttgaatc 1380 aacttgaata tgaagtgctt tttgtaaacc atttttatca gtttcaattt ttattttatt 1440 tggtttatgg acaatatttt gatgtgccgc atctaattta ttaggtttta taacatcatg 1500 attatcctta tcaacaattt gaattagttt ataatcatgg tgattttcta aatcttttgt 1560 taataaacgc acaagaccat cagtaccaac tattgccttt aaagtgtgta attggtgttt 1620 ttcatcttca aataaggcat taatattttg attagctaaa ttttgtgaaa cacgtgcgtt 1680 aataataacg tttccttgat catcaaaact gcgtgtttta tcaataccac gaatgggttc 1740 actaatttca tctaaattaa caatttttgt gtttttatta tcttctttta aagttaaacc 1800 tacgaattta taaaaatttc ctaaaggtag ttgtttagtt ccaacaatta cattaccatt 1860 atgatcaacc tgaatatttt gaatatattt agcattattt tgattaataa aatgcgcagt 1920 caaatactga ttactcaatt catggtttaa tttaatttca aaaaatttat cgccttcttt 1980 attaaaatta actttaaaga cattaggacg atcgacaagt attttttgtt gccataccaa 2040 ctcattatta ttgattaatg tattattatt ttcatcaaca atacgatcta aaactcaaga 2100 attattcaaa cctaaactcg ttgtgtcaat tcgtgctact tctttatttc ttgtaattaa 2160 aactgaagtt tccttgccta atttatcttt aaaaatcgca taaatctttt ggttaatatc 2220 attatctctt gtaaataaac gaaccttaat aattaaatta ccatcttttg tatattcata 2280 gtatttacta aaaatttgat tggaatgctg atttgcgaaa cgtaatacaa ttcctgtaat 2340 tacaccagct caaattaaag aactaattgt aagtccagta gctattttgg cattacgttt 2400 tttattttta ttattcat 2418 154 1134 DNA Ureaplasma urealyticum 154 atgaaaaaaa acacacataa gaaacttttg cctttaattt ctatttttgt tttaatccct 60 ttgagttcac ttgttgtaat gtgttcaaaa actaaaacaa aaatagtaaa agaacaaaag 120 caaattactg cttcatcgtt aagatctact gatattgatt taacatcaat taaccttgaa 180 atctattttg ctaaatttga tgttaatgat attttagtta aaaaattcag cattgaatta 240 gaagatgata agggaaataa gataaatgtt gatataaatc ccgaatataa caaaaattta 300 caaatgctaa gttttaaatt agaaaactta aaaccaaaca ctacatataa aattacaaag 360 tttaatatca caggacatga ggttgatcta actcaaataa aagattcatt attcactact 420 aaagctgaga atcttttacc tgatatccct aatttaccta atagtgttgg tattgaaatt 480 aaagatatta aaactaattc acttagcaat gatgcaacaa aagtgaatgt taatgtcaat 540 ttagaaatta accaatcaac attagaaaat caatatgccc gattagttta taaaagcaat 600 gataattctt gaaagctatc aaatacttta aaaattgctg aaattaaaaa tagtaatttt 660 gttttagatg gtttaatatc aaaccgtaaa tatcttttta aagaattaat tattggaagc 720 caaagtgatt taaatttaac taatgcgcaa actaaaataa ctactaataa tgagctaagt 780 ttcactacag ctccaaaacc tgttgaaata aaaagtgttt taattgatac aaaatttgat 840 aatcatccaa gtagtttaat taatttgaag tttaatgata gtgagaataa tttaaaagaa 900 aatgatattt taaaaattaa atataaaaaa gtaggaccaa atgaagtcat ctttgaaaaa 960 acagttcgat tagctaataa ttttgaacta ttatttgaaa ttgaaaatac aaaaaagaat 1020 gaaaaatatg aaatcttaag tttagaatca aacactaaac atggatataa tgttgcacca 1080 agtatattta attttatttc taatgattta cgcacttttg aaatcaaagg ttaa 1134 155 1692 DNA Ureaplasma urealyticum 155 atgtctttaa tttatcttct aataggtttt attttattat ttttacttat ttactctact 60 tttgcattat tggacatttg aacacttaga aaatataaca cattccgtca aaattttttt 120 aattttgatc aattagtcaa tacaaaattt aatgatattt atactcatac agataatatc 180 tatgcacgta caagtaaaca aaaaataaca attattaata aatacctaat tgcaattaat 240 aatgaattag attttcataa aaaaagtcta attaaattac aagattatct tgaaaatcat 300 aaattattct cttatttatc acttattaag tttattaaag caaatgaaat taaaattaaa 360 aataatgtag atgaatttgt agatttaatt caatcttttt gaaatgattt tattattatt 420 gatcaacaag aaagaaaaat tgaagatacc cataagaaat tagatttaat gtataaagat 480 cttataagta aatatagtat tccaaattta aattatcaaa aagcaattaa ttgaactact 540 gattcattta ataatttaat tgaaactaaa attagtatga attattcaaa gtataattat 600 tttttagttc aattaattca tcgtattaaa aataaagttc atttattaaa aaatatcatt 660 gtagttttaa attcaatcaa aattattgaa gaagctaata aaaatagctt acaaaaagtg 720 caagaaatca cctttttgac tgatgacaaa attaaagaat taagacaatt taaccatgat 780 tttaatgatt ttattaataa ccaattagct gattttattt ataattcaaa atttgttaat 840 ttaaataacc tttatttaaa tagttattat caacaagcct taaattgact taatattagt 900 tcgcaaaaca atattggtgg ggctgttttt gataaatata aaaaacgttt ttatgatgat 960 tttagcttca ttaatagcac tattattaaa gtaaataata ttttagaaaa aataaagagc 1020 acttcaaaaa actatcaatt aaaccaatta aaccaattaa ttttagactt agatcaagct 1080 aatcaaaaaa ttattaattc taaaattgat aaaaatgata tcaaacaaaa tattgatttc 1140 attatttcaa cacaattatt ctatgataat ttaaaaaatt tattgtttta tttaaatgat 1200 ttaaatgtta agttagcaaa ttggaatcac cactgaaata cactagttaa aaaaactatc 1260 actatttata ataaaaaaat cgaacttgaa tcttatatta aaaacaaaga tatatttttt 1320 aatttatcta atgaaatttt tttagatgat ttcgaatata ttgaaaatat atttcaaaaa 1380 ataaatgctt caaatagttt tgatccccaa attttaacca atcatgagtt aattattcac 1440 caattaaatt taattaatga acgttttgat tatcttattg aatatattaa ccaaacccaa 1500 ttatggatgc caaaaatcta tgatttgctt tataataaaa taaattatta tggtatcaac 1560 tatgaatgaa taaaaaaaga atttcaaaat ttaaattgaa acaatgtgcc tcaagcatct 1620 aaattattaa atgaatttat tgataatatt attattgctg atcacgcttt aaaacgttta 1680 aaatttaatt aa 1692 156 822 DNA Ureaplasma urealyticum 156 ttatatttta tctagttctt gaattaaatt atcgattttt tgaatctcaa cttcacgttt 60 tgttttatgt ttaggcgctt gttttggttt ctcataatgc atccataata aaacaacttt 120 tgctacttga tcatgtaaag cacgtttttt tgaattcata aacatgtgaa ttacaataat 180 acaactaact aaacccataa ttgaatatag acttttaact aaaatactta aaatagccat 240 agttgtagta ttggtgaaat tatcattaat ttttaaagat aaaattgact gcacataagc 300 ttttaaatct ttaatttgat gataatactc ttttagctca gtctcattca tagcttgaat 360 tgatttaaaa cttgcatcag caaaaacaaa acaaaatccc atcgctaata aattaattat 420 ggtaaaaatt aatcaagtta ataaactatg tttaattaaa gcaataaata aaattttttt 480 atcgttttgt tttactaaac taatcattct aatcgaaaat gctcatcgaa ataaagtata 540 agatttacaa aataaaggaa taataatgta gtatgtagaa taaacaaaaa aagcaattat 600 tcccattaag aataaacgtc aaggttcagg agcaagctca tcattattaa caaaaatatc 660 actaatttta aaattactat taataaaaac taataaagat aataaaaaag caataatgga 720 aataaaaata taatctaaaa cactagcgct agcacgcctt agtgcaccaa caacgggata 780 ttcgatcgta ttttcttgtt ttaatgttga cttatcactc at 822 157 1164 DNA Ureaplasma urealyticum 157 atgaaaaaga aggtgataaa aatgatcaat aattcaccaa acattaatta ttatttacaa 60 gataaaaaat atattccaaa atatgcttac tatgttaata aaaaacaaaa acctatcgag 120 ctatttgcac gatataaagg acgtcctgct ctttttattc gtgaaaatac catgattaat 180 acttcattaa attcaaatgt attaaattta gactttgaat ttgaagttgc aggagatttt 240 aaattaccta ttaattactt ttttatggat ataaaaagtg atataggtga atttcgtaat 300 ttagaagttt atgaaactaa acactctttg tatgaaatcg gaggagtgat ttatgactta 360 tacacttata aaaccaattt aaaaattaat cttaatcaag ctggttttgt taataagaac 420 actttaagta aaaaaattaa ttttgctttt tttcttcgta ttaatgatga taaacgaatt 480 catgaacaaa ttaattatac atgtgaaaaa agtttgtttt ttgaggcagt acaaaaagaa 540 tttcaagatc ttaattttga ttatttttac aaaaatacat ttttattaaa taaacacgaa 600 aaagttaatc ctactaattt ttgagaaaca attccattat tttgaattca agataaagaa 660 cttgataatg aaataaaaat caaaaataat aagcgttata tatttaatac aaaatttagt 720 ttaaatgatg ataattcatg aaataatcgt cctacgaaag aaacgtttga attgattaaa 780 tactccttag aatacgtaaa tttagctaaa gaaaataaaa aaattgaatg aattgaagat 840 tatcaaaata ttaatattac atatgattat taccaaagac ctattgattt tttattaaaa 900 atgaaaacaa aattcttgta tgattttaaa aacgatcaat tatctattaa taataattat 960 ggttttaatg gtatttgatt accaaataaa caaatagcaa aattaaaaat tacagttatt 1020 aataattatc taacaccaca aaaatttgta attaatcaat taattaacat cgaaaatgat 1080 tttaattcta tcaataaaca aaaaattagt gtacagaaag caataattga aaattatgaa 1140 aattttaaat cacttgaaaa ttaa 1164 158 861 DNA Ureaplasma urealyticum 158 atgaaaattt taaatcactt gaaaattaat tggcgtagtc ataaaataaa ggtgattgtt 60 ggtggaatta ttagtttatt aattgtaatt actgctatta ttttaggtgt tattctatca 120 actcaaaata caaataaaat tagtaaaaaa gaacccttaa ctcaaattga agataatatt 180 aataataaaa aacaagatgc acataaggtt aatgaaaata taacaattat tgataaaaaa 240 ggtggtataa tccataaaaa gacagacatt acaaaaatta accaaataaa tcaacaaaaa 300 gaaattttaa aggattattt aaaaaataaa gaagaaaaaa ataaggatca aataaataat 360 actaacgaaa atctaaataa accaataatt aatgttaaaa atgtagatga taaaaacaaa 420 caagaaaatt caactaaatt aaaaaataat gattttattt ctaataatga taaaaacaat 480 aaaatcaacg aaaataataa tataagttat gaagaaaaac cttttaaact aaaacgcttc 540 aatattatta atgtaattgc gaaaaataaa gatttatacc aattattaga tttcaaaact 600 tatttttcta atgaaaacat taataatgat attaaattta atgaaaagtt gtttattaaa 660 aatatctatg aaatagtcaa atctgctata agtagttttc aagaattttg taatatcatg 720 cagtatatta aaattgatat caaatataaa tttaataaag atgcaaaaaa cataattgtt 780 attgctaatt gattattcga taattataat attaaaaatg aaacaagata ttatgaagag 840 tttgttttaa gtattaatta a 861 159 1794 DNA Ureaplasma urealyticum 159 ctattttcat aaaatatggc ggattcattt aaatgaatat tgattagtaa tttgattatc 60 tttataatcg tttttattta aatacttgta gtagacaatc gtaaacatta ataaagaaat 120 aattaaaatt acagcactag atattgataa tggcattgat cacgccaata atccagcaaa 180 cttaacacta ctttggtaat caacaccaaa accaacaaca aaagcaatta ctaaaacttg 240 caataataat gttggaaaag gtgattgttg ctttttagca attagatcac gataacgcat 300 taatgttaat gacaatgagt aaaaaattgc aaatattgtt aaatgaatat atgtattatc 360 accaattaat aattttttaa ctacctctgc tgaaatttgc acaaaagatg tggtaattgg 420 attatcaata ccatataaat atttaaagtt aggccctgct gctcaaattg gagttattaa 480 ttgtttaata acaacttttc atacctcagg attatggttt gttaagtgtg ctaaaatcaa 540 tcttggatca atatgggctt gtgcccctaa aaagtatact aatcgaggat tatttaaaat 600 tccttgacga attgacatat aaaaatgatc tggtatttct gcatctaaat taatatatgc 660 ttcattttgt tctttagcat aaacgactga tagaggtttg attgaaaaac caaaaataat 720 tgctgcaatc attaaataaa caaacaataa accaaaaaca caaataaata attggcgcga 780 atggtaacga cgatcacgaa tagtttgttt ttgaaaaata taaaataggt aatcagtaaa 840 acctaatcca atcccttgaa taaacaacat cgcatgatat cataaaattc gaccagtttg 900 tagatttaaa ggaacagaat ttgtcatttt ttgattaatt aaatgatata aagctaatag 960 aacaaacatt tttataattg aactaaaaat cgaaattaaa gtttgatttc aaatttgttt 1020 aatgctaatt tttaataaat ttaatgataa acctaattta gatatccttc aatctttact 1080 aaatttaata atactaatgg caattgttga aataatataa ccaattgaca atcctaaacc 1140 atacccacta taagctaaaa tactatattt acctaataaa aaacttgtca ctaaacaaat 1200 tgttcatgtg gcaaaatcta aaataatagt taatagaatt ttacgacgat catttgttca 1260 aatagaaatt aaaaaataat tatgaactgg tgctaaaacg ataatcccca aacttgatca 1320 tatgtattgt tcaccaaata gttgagcaaa caaggtattt tcatgaatgt ttgcataaag 1380 attataagta taagatgtcg ccaaataaac acccaacatt attaaaccga atgaaaatgc 1440 ataaaaactt gctaagttag ttgttgaatg tgatggaaca aacttgtgtt tacttccatc 1500 atatagtttt ttagctcata aggctaaaac tacacctata tttccaccta attgtataaa 1560 actaaattgg aaaacaacaa tatagctaac acttgtcgca gcaaatgcac cactaaaatt 1620 atgtaacgct attattattg taattaataa taaagctaac gatgagaaca aacttgaagc 1680 tataaacgat gagctatctt ttatgacttc tcataatgtt gtaaaaatgc cataatgttt 1740 tttaaaaaca tgacgtttaa ttacaagggg cgttttttca atcgatgatg tcat 1794 160 1836 DNA Ureaplasma urealyticum 160 ttaattttga cgaaccttaa tttgttgttc taattgtttt ttaggcataa ttgataattt 60 ttcatcattg tacttatgat tctttaaata tttacgataa atacgtaaaa ttttataagt 120 gctatatcct aaaataaaaa tacttgatat aaataaagga aatgatcaag ccattaaacc 180 aatgaaatgt ggatctgatt ggtgtgttaa cccaaatcca gaagtaaacg caaccataac 240 taattgaata acaatcatta catatggagg acgttgtcgt cgggcaatta atcctacata 300 acgacttaaa atagaagaaa aagaaaagaa tgtacaaaag aatgataata aaatataagc 360 attattttta attaaataac tataaatatt tgaagctgaa atatcaacaa atcgatgtgt 420 aaaaggattt ttcatttgat atatcgtttc aaatttatca cctagttttc atattggatc 480 aatcactttt tgcgccattg gtaatcaaat atttttatca tttgatgata aagcattaac 540 aacttcttgg cgaccaatat tcacatgact agtaataata tctaataatt tttcatcatt 600 aattaaaatt tttcttaaag attgatagaa atgttcggga acttgctttt ctaaaaatat 660 ataagatgga ctttgttcac ttgtatacaa ttggactaat tgttttacag aaaaaccaaa 720 aataactgaa gtaattaaag caaataaaat acctaatata aaaactcaaa aaaataattg 780 tcttgaatga taacgacagt ctctgacttc ttgtttttga tataaataaa ataaaaaatc 840 tgacaatcct aaatttaaca tttgtatgaa aatcattgat tggtacatta gaattctcgt 900 tgattgaaaa tctaataatg atgaaccaac tacacgtgag ttaattacca caaatgtaat 960 taacaaaata aacattttac caactgattt taatgatgat aaaatcgttt gaattcataa 1020 taatttaata cttaaaacaa ataatctttt tgaaatatat aatggacgta aaacaatttg 1080 ggctttttca attgtagtca taccaataat aatagttcaa aaaacaaaac caattgacat 1140 accaaggcca tagccccaat aatttaaaac actataacta cctaataaaa aagctgcaat 1200 taatgcggtt gttcatgtac aaaaatctaa aacaattgct aataaaacat taatggactt 1260 ggttgatctt attaacatca ataaatagtt tcgcaaaggt gctaaaccaa caactgctaa 1320 tcctgaaaca atatatgcac tacctacact ttgattaatc actgtatttt ggtgatcatt 1380 tgcaaaatga ttataaatgt aagaggttgt aaaataaatt aataaaacta ctaaaccaaa 1440 gataaatgaa taaaaactag cagcatttac tgtatcattt gtaggttcaa acttatactt 1500 accatcttta aatgatcttt ttgaccaaat cgcaaaaaca atgccaaagg ttgttcctaa 1560 ttgtaaaaaa cttaactgaa agatagttaa ataactaata ctagttgctg cataagcacc 1620 aatatcttta tgatgagcaa caattacaac aattaaaatt aatgatagtc ctgtaaaaac 1680 acttgcagcg ataaatggcg agctttcttt taaaagttct aaaagtgttc taaaaacggt 1740 aagatttttt ttaaaataag aatcggattt tttaataact ttcatttgtt tctgttcttc 1800 caaattaaat ctcccccttt tatataaaaa caccat 1836 161 2427 DNA Ureaplasma urealyticum 161 atgaaaaaaa tgtttctatt aatgaagaat atgatgcgtt tattctttaa aaataaaact 60 ttagtaactc aactttcaat tttaatgatt gtttcaacag ttgttattgt tgcaacaacg 120 attacagtac aacgtttgca aaaatcacaa agcgatatta aaaaaattgg tttacaaagt 180 gattttttaa ttgatacaaa agagcaagat aatattaatt tcaacgaaat tgacgttagc 240 aacaatcttg taaaacataa tgaaaaatta attcaattag caacttttaa tcaaaatatt 300 ttaaaaaatt caaataatta tttacaacta gttgataatg catttcataa tcataacctt 360 ttttggccaa ctaatgtaaa caatcaaaaa atagatgtac taaatcttga aggaaatatc 420 gattgaaata aaattaatca attaaaatta caaactgttt tttgatttga aaacaataaa 480 gaaaataatc aaaattttgc taacaattat gatgatttgg tttatgaata tcataattct 540 aaaaatcaat tagtaggatt tcaaaattta gatggtgggc atattttatt taaaacaccg 600 gcgttaaaat cagcaaacgg taattatgaa acaacattta aaattaatgc tgcaattgtc 660 caaaaaaata aaccatttaa atcttttttt aactttgata aatataaaga attaggattt 720 aagaataaat cttattttac aaatcctgta ttaattaaaa atatagatct ttattcaaaa 780 caagttgttc aaacactaaa cgatcgttca aatcaatcaa ttgattttaa agactatcaa 840 agcacatttc aagccattgt tgatacactt gaaactaaca cgataaataa agatttttat 900 agtgtgaatt tacatgttga ttttaacaca ctatcaacaa aatacctact atttgctaat 960 tatttaaaaa atgaaggtat tgataaaaac cgttatataa atgaattaaa aatcgataac 1020 tataaacaga agtatttaga tttatttcaa aaccaagttt taattccaaa agaattaatt 1080 gacgatccaa aaaaaataga agaagtgcaa aaaattattg caaaagccaa agccttgtta 1140 attgctaaaa ttcgtgaaga aacaaatatt ttttatgaaa actcacaaaa atcagctctt 1200 gaaaataaaa ataagattcg tgattatgag atgcaattaa aacaaataaa tattgctcta 1260 caaaattcga attattctaa taacgaactt attcaattaa aaaatgaaca aaaagtatta 1320 gcagcaaatc tcgatcaagc aaaatttaaa cactttttat ataatgattt aattaaacaa 1380 gatttccgtt cgattttaaa taattataat atttattatc gcaaacatga atcagcaatt 1440 tataatgatg ttaaaagtga ttcaaatttt attgtcacaa atgcaagcaa tccaacatat 1500 acacaaaacg gtttaattgc accaagaaat caatgaattg ataatatggt gcaaattaat 1560 gaaaaaaata aaaatagtca aaatccaaat aaaaaattta agcgaatttt tattaatgat 1620 gataattcaa ataaaattaa taacttttat gacctttatt caaattacat taaagtcatt 1680 caaattttaa aaaatagtta tgaaaaagat ccagatactg ataaagattt actagttgaa 1740 gagcgtgatt atactccttg aattaataca tcactaatta atatatatca acttccacaa 1800 ttttttaata tcttatttaa tcaatctgaa tgattattat caattcaata tctaaaagaa 1860 atgagtgatt ataaaaaata tttactacaa atttttgaac catatcaaga taaagaatgg 1920 atttttaatt taaaacataa agattgacaa gatggcgaac aagtggttgc tatttataaa 1980 aatgcagata gtaatagcga ccaaaaagaa tattatttta acggctatgt taaaaatcaa 2040 cgagcttata ttaatgttaa atataataaa aatctgccaa cacgtttaaa attaattaat 2100 attattaaac aaaatcaaat aaatcaaaaa aacaatttag ttaatgtttt agatcaagat 2160 ttaaatgatt atgcaaagat tattaatttt aaaaaaggta ttaaagatat taatacaaac 2220 cagcaatcag tttatgatca gtgagcttta aataatccac aagattatgc tatgtttaaa 2280 atttgattat caaaaatcat taaacgttat tattttctac gcttcagcaa tcaccttatg 2340 gatatacaat tcaagcacaa aacgttttat caaaagcttt gttattgccg tttacaatta 2400 atattattaa tcgtagttca gatctag 2427 162 285 DNA Ureaplasma urealyticum 162 ttatttttca ttttttaata ccccataatg atcgattact tttaggcaat tatttagaac 60 ttcttcgcta ttattaccta cacaagaatt aatttcatct tctcgtaaaa aattatcaaa 120 ggatttatta ataatttcaa aaggtgttat attttgtaaa ttaaaaagct caaaaacttt 180 aatttcatta aataaattat ttaaacgatt ttcaacctgt ttaatttcat catcagttaa 240 tataaacatg catgatgaca ttaatttttg taaattataa ctcat 285 163 1767 DNA Ureaplasma urealyticum 163 ttatgaattc ttttcatttc atttgctata gttaacattt acacttttaa tttcattaag 60 gttaaaaaga tattttctaa aattattctt agcagcttta aaactagtca aattatgaat 120 attagcatcc ttattttcta aagcaatcat tgctaattgc gaatatgatt gttttgataa 180 aatttggttg ttttcagggt tagtaacagg taaaatagta cgagaattgt tagatgcttt 240 aattgcttca acaaatttgc gtgatttgat gaaatcatct atttttaatt cattgatctt 300 tttttcacct aagaaagcat atggataaac accatttaga ccacgatcat gttcataata 360 ttgtcagtct tcaagttttt tatcttcaac atactctttt ttattaactt tagcttcgtt 420 ttttaattct tgttttaaat cgcggcccaa aatactaaac gcatgaattt tagataatgt 480 acctgtgtag tattcattat aaacagttgt acgttttttc tctgtctcag ttaaccctgt 540 tttttgattt ttaattttta aaaaattttc ttgaagagtt tgtgttgctt tttgattaat 600 attagcagaa cgcattgttg atggtgcaaa attaactacc atatctttta atggaatttc 660 ataaactaaa ttacgaattt ctggtttgtg atcatcatga atttcagcat aagttttttt 720 atcaacactt gataaagcag cgttaattga actaagtgca tttagttgac taccattaga 780 actagcttcc ataaatgatc cagctttttt gtttgaagag ttatatcaag catattgtaa 840 tttaatattt tttaaacgta caagaacatt ttttaaactt ggattaacta ataattcatc 900 atttacttta acaccaaaat taggtttatt aatacttaaa cctgtaattg catctacata 960 ttctcaatca aaactaaaat tatataaagc aagtttgtat gtatgtttac ctgcacctac 1020 accttgtact aaagctaata aaaattcttt agcaacttcg ttttttaacc ctttaaaaag 1080 ttcaaaatct ttatttgaat ggttattaaa tgcatgttct gctaatcatt ttattaattg 1140 atctgtcata gaggtaatat aagtatacaa tccatcacta ataactaaag agttgattaa 1200 ttcactaacc ttatttattt ttgttaattc atcacttgaa tatagttttt ggttaaaaac 1260 agtttgtttt tttgtttggt caagaatttc taaattatta gcatatttac ttgttgaatc 1320 aaaatttaac ttattaccaa ttaaacgaat caattcattt tgcaaaatac tcaaatcaat 1380 tggtgttagt ttagttgaac ttgataaact ttttgttcaa acttcttttt tgggaaccaa 1440 ataaccaaat tgatcgattt ctttattgtt tttatcaaag cgtttattat ctttaacact 1500 cgtataagtt aaatcacctg ccgcataata aacatcatct aataaatttt gattctcaaa 1560 aatcatttca tgtttttgat tcttaccttc aaaggctcga attttaattt taccaatatt 1620 attagttgta gcattagcac taacataatg aacattaact tgaggatgag cagctgctga 1680 acacgatgca gcaacaattg gcgttaatcc aataaaacta attcctaata ttgaaaaaat 1740 tagcttttta cttttgtttt ttttcat 1767 164 489 DNA Ureaplasma urealyticum 164 ttaataagcc gagatatatt cttcttgtaa agtgtgactt ttttttcgat ttcaattaaa 60 tactttatca tacacaactg ttaataaaat tgatgagaca tagtgtatga aaggaattaa 120 tgaaataatt aaagcttttt taactttcgt tttattttca ttaaaatcat ttaaatactt 180 aattaaaatg cgaatattaa caactaagct aattaaatat gttaatgttc ataaaactaa 240 aaataggcca aaaaaaccaa ttgataaacg aatttgttct ttttgtgata aataaacttc 300 taaatcttta ggatttaaca tgttaattaa ttctttttca tgatttaggg tatatgcatc 360 aaataaatta tgacgcacta attcatgacc aattcaagct cctacacaaa caaataacgc 420 agctgcaaat aaaagtaaaa ctcaattttg aattgaaata aactttaatc ttttaaaaat 480 taaatccat 489 165 3396 DNA Ureaplasma urealyticum 165 ttaattatcc ccttctgctt gtggtgatgt tggtaaacca ggacgtggag gtcttcgata 60 atcataagca aattgtaaat aatatgtaaa gttatttttc ataccaccaa gtgatgaaat 120 cgttcagttt gtatcaattt ccataatagg cacaattgct gcttcatcac gtaaaatttt 180 ttctaaattt aaaattgttc taaagatact atcatcatct tctcaacctg gacgattccc 240 tgaaaagaaa tcaataattc ttttacgttg atcaacaact gtttctaatt ttgtcatata 300 aatttcatta ttaactttat cagatatttc attattctca tttcttaagt acttacttaa 360 taatggtttt aaatcattta tgtaagataa gttgattact tgatatgatc caattggtaa 420 ttttttaata gaaaatttgt atttaaatcg ttttttgaaa ttaatttcat caatattttc 480 tttattataa tattttgcat aatcttcttt tgtagcttga acatattgat ttgttttttt 540 atcgataact ggttgaattt gtagcgttgt aaattgacct gttacattat tttgcaatac 600 tagtaaaaac ggtttatttt cacgttttgg atcgtgttta tttaagaact cttctgataa 660 ataaaattca cgttcttgca ttgtatcaat ttcgttctgt agattattag cttctttttc 720 tcacgttgat ttcgaactac ttgtaggctc atttttaatt ttttgattta atttattaat 780 ttggtgttct aaatcatgaa tgatcttagc gtcatattca gaataattaa catcaaacat 840 tggaatggct ttatctttta attttaattt acgtaaatca gctctatttg ttaggtgttg 900 tggattataa acttcacttg ttttaatatt tgttggcgtt accaattcac gaataatatc 960 agcgtcttct tcactaatat gtaaacgttt caaagcgtaa tctaattctg ctttattttt 1020 ataacgatca aaaaagtttt ttggcgttca agatcctgtt ggatttaatt cataacctga 1080 gcttttatta ttttttaaat caattccatc aggtgttaaa aataatccta atgctgagtc 1140 ataagtacta ccagcatatt tatcaaagtt ttgataagaa atatcaaatt taccactatt 1200 tgcaaatgtc acaaatgtgt ttggcggtaa tgcttgtaac tctaatttta cataaccatt 1260 cagattacgg tcaattaaat ctttaatagc aattacagct tttccaatat cagctggttc 1320 ggtaggataa acaaatttta aaacaacttg ttttttatct ggatgttttt tcttatattt 1380 atctaaataa aatttagcaa cttgtggatc aaaaccagta tcttttcggt taatattttc 1440 aaatgttgaa tttttagcag caacgtggtc actaaaatca ttattttgga ttaaaaaaga 1500 acggttttgt tttcttgttt catgtgtttt ttcatcttta atagtatcaa tgtattcact 1560 atcaaaacgt ttattatcaa atcaatattc taaattacgc ccttttgaat ctttaattct 1620 ttgaaatgat gttcaagttg taactggaaa agatgaagtt caaccagata attttaatat 1680 gttttctctg ttaatagcaa aagcaattgc acgtcgtaaa tcaggatcta ggattggaat 1740 gtccttatta ggatttttta aatattcttg ataactatca taacgtgatt gacgatctaa 1800 attaaattgc attgcaaccg ttccagcccc tgcttgtttt ttcattaaat cacgcatttt 1860 actttgcgct cagaatttta attgatatga tggtggaaca gtagttgatg aaatcatccc 1920 ttgttcaaat caaagtgatg taacttcatt tttagaatta aaataaattt taatcttatc 1980 gctaattgtt caattagctg aaaaataatc tttatttttt tctaatgtca tataaccttg 2040 aggtcctaaa acaacatcag caatattaaa tggaccgctt caaacaaaat tttcaagagt 2100 agaaccgaat ttttcaattc caccatgtgt ttcaataaaa cgacgattaa ctggtagtaa 2160 agcttggttt cctaaaatat cagtcaataa aacactaaat gaaggttttg gagcataagt 2220 ctcaaattcc attagtaaat caaaacgtga agttggtaat gatttaaatt taaataaatc 2280 ttttgaatta gctaaagttt gtaaatcatc acttgccaac ttttgacgat gattaaacga 2340 agggttttca attaaattaa taacaatttt ttcaggtgtg tttttatctg gttttttatg 2400 atcatattta ggattaaaaa ttgttaaagt ttttgactca tgaaatttga aatccttatt 2460 ttcaggtaat tttaaagctt cttttaattc tttatttgaa atattagtat aggcttgacc 2520 tgtacttaat ccaatttcat aagctgcttt tttaattgcc gcaatttcta gatcatcaac 2580 agggtgacca tttttatcaa aagtttggtt ttggtatgga acaaaattag gatcttcttc 2640 tcattgacct gtttgcttat ttaaaatata tggagcacga ccaaaagggt ttttataagg 2700 aacgccatgt ttacgaatat attcttcttg agcatcatta aaagcgtttg ttcctttgat 2760 gttaaaacgt aataagtgtg aacgtaattg actaccagta tttaagtcta aaatatactg 2820 aattgcatca atgaaatctt gtgcattaac ttctttacca tcacttcatt tcgaagcgcc 2880 aaaattagtt gtaaattttg ttgcaacaat acgattattt gaattgttat aaaaaactca 2940 tgttggatca tcttcactaa ctgttggtgc taacgctcca gaattaattc caaaagatga 3000 taaatcaaca tatgatggtg atattctcat accttctaat tgtgcatcag tcatattatt 3060 aaaacctgca tcaactggat ttttatattg atttaaaaac aactttgata ttcctaataa 3120 gttaccgatt gttgaatttg ttgatggcgc ttcttttatt aaaccatcta ctagtgaaaa 3180 tacaatttta cgaagcgatg caaattttac ataattcaat gtgttgattg catccattgc 3240 caaaccaaaa ttactaccat cttctaaata tggactaatt ttattttgtt ctttagtggt 3300 cttagttcta gcacaagaag caataatcgc agcaacggga attaaaccaa caattccaat 3360 agataaaaat ataattttct tatttatttt tttcat 3396 166 5652 DNA Ureaplasma urealyticum 166 ctaaactgag aattggtttg aaattctaat aattgtacga tttttatctt ttgtattttc 60 gtttcttgca taaactggtg aaacagtata tgatttaccg ttttcagcaa catatttgcg 120 tgaacctaaa gtcattaaac tttttgggtt ttttggatca cttaaatcca taacttcttt 180 tagatcttta tccacaaaat atatttcaaa ttcacttcct ttggcattaa ttgaatcata 240 accaattaat tggttagtga aattagataa aattgcataa tcacttgttc atgaaacata 300 accttcatct tctaatgttc atttagaatt aatgtctgat tgacgtttta gataaaataa 360 attatttgta ttatctgtgt gaacatcgat atattctatt ttgccattat ttttattttt 420 tattgcaatt tttttaactt tatccttata ttctttttta aagaaaccat acattaaaat 480 agaatctttt tctttatttc gataaatttg agctaatgtt cgatcaccaa taccttttga 540 tcttaatata tatagtcaca ttgctcgagc acgatctgtt acttttgttt tattatctaa 600 ttccaaaata tttaaatgat catctttaat tggttcacga ttgtcatcat aaatctctca 660 atcaataatt tttcttaatc aacggtcttt gaaaaaacca ttatttgtta atcttgtttt 720 accgatatat gaattagatt taggacttaa acgtgttaga aaagaatatg aattcaaatt 780 atttaaaaca tcactatcat gagtttttgt caatgctaaa aagttagcat tagataaaaa 840 gctttcctta actttattaa aattactttc taattcttgt ggttttgtta gataatcatc 900 aaataactgt tgattttttt gataaacatt taaagcctga tttgctaaaa cattttgaat 960 tttttcgtaa ttatttgttg caaataaggt atttaatgcg attgtatttg atacacttaa 1020 gaaattattt actggaatta aacgctcgtt tcattgtttt gtattatcac cactaaagac 1080 atattcattc cctgtattaa aatcacttaa acctgaaata taatttggta ggttatctaa 1140 ctcattttgt gaaggaataa atacagtttg tacataatca cgtgttaata cctcagcaat 1200 attaaataca taatccccaa aaatttcgtt taatttttct tgaacacgtt ttttatttaa 1260 tgttacataa tctgatgaaa caacagttcc atcagcattt ggaatttcag acgattgaga 1320 aatcccaaaa aatgatccta atcaaccata aatatctttt gaaccaccag gtatatcagt 1380 ataaattgta aatccaaaag catattgtaa taattgacca aagtttaaag tgttattctc 1440 acggtgtttt cgttcaattt caagttgaat tcctttaata attgaatcaa cagtacgtac 1500 atttttttgg tttggttttg cttttcaaac attctgtgga ttaccagcaa aattatatgt 1560 atcaagtggc tctccatatg gtgagcctgg tctttcatat ttattaccaa aacttctaaa 1620 tccatataaa cctagtttgc catcaaacac ttgtttgtat ttatctaatt cagatgggtt 1680 aaaatctttt gatttataaa atttaaaaat atcattagat tctgtaaatc catcaaataa 1740 taaacctgtc agattttgtt taaactcttc tagtgttaga tttttatatg cttcttgttt 1800 ttttattact tcattgaaaa atttatcaac atcataacgt tcttttaaat attcataatc 1860 tcatttacga acattttcat gacttgagct taaagcattt tccacaattg tatatttagc 1920 tggatccaca gacataaatt caattaaaga aggaatatct ttaaatttaa ttgtgtagaa 1980 ttttgatcca ttattttcaa gtgtaagagg agtgaatgat ccattatttg attttagata 2040 atcaaaatta attgcttgtg cttcagcagg cgttaaaatc attaatgggt aaatttcttt 2100 ttctgttaat tcgtcaagct tttttaaatg tttattatct tttccatcac ctctatcaac 2160 aatcaactta atagttccaa attcatttaa atttatcatg cttttattaa ataattgttc 2220 atatgaagta attttatttt gtgtaagata gctaggacgg ataccaataa ttgattcaac 2280 tgattctttt gtttttgttc ttaaaatatt ttgatatagt tctttttctt ttggtttaac 2340 aaaatattta taaccattat taccttcaat tccagcgtca aaataattaa ataatgttgt 2400 ttgagcaact acattaacat ttttaacacc gaaacgatca aactgtttgt cataatattt 2460 tttaatttct attaattctg gatcaagttt gctgacttct tctttagatt tattatctca 2520 aatttttgat gcattgtatt gtaaagttaa taaagcatat ttaaattggt caaaggtttt 2580 atttgtaata tcttcgccaa taatttgcga aagaactttt ttataatatg gaacagatga 2640 tgcattcgct ttttcatcta attttaaaga tttgctaatg ttaaaatcag ggtatttaaa 2700 catcgcatca gtaattcgtt cagctcattt tcgtttttca tttgaagtaa acattgggtg 2760 atcaaaatat gtttttaaat taaacattga tgtatcaaaa ttaccgtttt catctcaacc 2820 accattatag taatttttaa cgattaggct attaattgaa tcttgtatct ctctcacttt 2880 ttcattaagt tttcttgtgt taattgtccc atctgatttt aaacaagttg ataaatcaat 2940 tactggtgta ttgtttttgg ttttaattaa aatttcaata tcatcttttt tgtatggatg 3000 ttttttcttg tgaagtttat aaacaattgc tctaccatct ttactaaatt taattggtgt 3060 tcccatacca tcttttaaaa taccatcata ttttgaaagt cctggttttt caataacact 3120 accaaattta aaattatcat ttttttgttc ttgactattt tgatcattat aaaaataata 3180 ttcagctttt aaacgacttg gatctttaat gtcagggcca aatgatgggt taacagttgc 3240 agattcatga tcaaatgaat tcataataaa taaatcatat ggtttaacat tacgtaattt 3300 tgccgcctca aataattcat cgtatttttg taaaaaacga cgttttttat tatagaaaaa 3360 ggctttagga tcatcagcat taacggaacc aaaaatatct ttttgtgttt ctcaaactgg 3420 atttttagga tcgttattta atgaaaaatt aaagaatgac ccatcttttg ttggattata 3480 atcaacatca gtttttctaa aggtaattcc gctagaacgt gcatttaaat aatcttgtaa 3540 tgccttacca tttacatatg attcatcact aactcccgat ctagaatcaa ttcctccacc 3600 aataactgaa tcattactat cactaatatc tttcatgtct tgtaatgttt ggtgatgtcc 3660 atattcgtgt gtacttacat attttaaata gttaatacct gttgttttaa atgcaggatc 3720 agattgagca actaatgata aataaggaat tcgatcagtt acataaatac cttcgtattc 3780 accattaaca actttatatg tatttttacc atatttatct tgaacaactt ctgtatgaat 3840 accattaatt ttttgtaata aatgacgatt tttatttaaa accttatcta ataaaccgct 3900 atatgcatca acataaatag tataagtttt aataattttg ccgttaacaa atttacttcc 3960 ttgtttaatc aaacgaggtg taaaaacatc aaaataatta gccgcaactt taagagtgtt 4020 gaaagcatca tcaaaacttg aatcataatt ataacctttt ggattatttt taggtgattc 4080 taaaattaaa tctttatcat cttttgttgt taaaattagt ttatttaaac cttcgacttt 4140 tgttttagta atagttacca atgaaacttt tttctcatca tagttaacta attcagattc 4200 taataatgat tcttttgatt tataaaaatg gggattttta ccattaccat caatatcata 4260 aatataaaat tgtttatttt taaatgtaga ttcaacatca taaacatttt taaaattttg 4320 tttttgatca atataatcat taaaattttt agtaattatt tcacgtaaac ttgatgctaa 4380 aatactatta tcattttgaa taaattcatc atttgaactt gatttagtag tgaattcatc 4440 cttaaacatg tagtatttaa ttttttgttg ttggccacca atggttgcat caattagtaa 4500 ataattttga ttaccacttg atttaccaat tgattcaaga tcaagcgaac caccaaaagg 4560 agatgaagca ctagcattaa attccaaaaa ttcattaatt ttaattttat taatttcatc 4620 cattttaacg tcgattttag gattaaattt tttatctttt ggaattaacc ctttaacaaa 4680 ttgtaattcg tttaaatatg cttgtacttt ttgttttgct tgttgttcgt tttgagcata 4740 aaaaagataa tttaatgttc gatcacttgc tttaagattt tttaaattag gaaaatttag 4800 tggatctttt gttaaatcaa agtacttatc agcattaaat aaataagtat tttttgcgtt 4860 ttttaggaca tcaattaatt taacaccacc aaaactatgg ctattatatg ctgaaatcat 4920 taaaggaatt ttttgatgat attcttctaa ttcttctaat gtcatagcat ctttattaac 4980 ttgtcgtgct aatgaatcat aagcattgcc ggggccagca ttaatattat aaattggtaa 5040 tgaaccaaaa aaagcatctg ggaagaattc aattactgtt ctttctcttg taccactatg 5100 taaccctagt gtaattgcgt taccattttg ttgaattcca cgacttaatt taaattcttt 5160 caaagtcaac aaatccggtc ctcaagaaac atttttaaag aatcaattag taaactcaat 5220 gaattcgtct ggagaaatac tattgatata attgttattg aaaacaattg ggcccacttc 5280 taatcttaaa tttggtaagt tgttgttatt taaattaaca aaattatcta aaaattcaag 5340 ataagaaatt ttctgacctt ttttatattt tccaaaatca attaataatg ttacttgtgt 5400 attattacct ttttttgctt taaaatcata atcagcaact ggtttgccaa attgatccat 5460 taataaagca cgatctactt gacgattagg aattgtcgta tcaaaactac tgttaacttg 5520 taatgtttga cgtccaagtc caccagtaga aacagcatat aatttcataa aaccaacaac 5580 agcaccagca aatgcaccaa ctgatgcaaa agcaattgca attttagctg ataattttaa 5640 cctttttttc at 5652 167 441 DNA Ureaplasma urealyticum 167 ttaagtaatt gattgtgtgg ttttaataat ataagcaatc atacaagcta atgcataaat 60 aaaactaggt aaaatgataa ttgtaattaa aatatttaag cgaattgtgg cataatcaat 120 agatcgtaat tcatatttag cattgatata aaaacgatca actaatttca tttctcacga 180 actaagttta tactcattat attttcttaa tttaactgct caacggcgac gataaacttg 240 gcgcgagaag ataatatata agaaaactac cataaagata catgtataag ctataaaaac 300 attcatacgg tattggtgat aatctttaat taattcaaca attaagtgac taataaccat 360 caatattaat aatgcaatta aaacaataat gcttttataa tttaataaac gattcggaaa 420 cgattgtttt tttatactca t 441 168 1194 DNA Ureaplasma urealyticum 168 ttaatgacaa aaaccatcag catggcaatg atgaatacta cctggttttt taggttcaag 60 tgttaaatca aaataactat acatactata aataacatac attcctttaa ttagagcatt 120 attgtttttt tgcccctgaa ttagaagatt ttcatataaa ttatctaaat actctttatt 180 tgtttttaaa ttaaaaggtg taattttttt accattcttt ttaatgaatg ttggtgctaa 240 aaatgcaatt ggtgaaaagt aaaaatcatc taatttatta tttcaaatat tggtataaac 300 aagatcacgt tcgggtttaa tagatgtttg tgcaggacga tcaacaataa aaatttgttt 360 taaaacaaga tcatttaaat taaataattt aacatcgtta tcaatattta aatcattaat 420 tttactaatc atataacgga ctttgttttg attatcatcg gttggtatag cttgtttaac 480 tcaacgatat aaactaccac cagttattgt atatccttca taatgttctt tgctatctgg 540 atatttaata atcgaatgat aaattttgac atttgaataa ttaatttgca tgctaatagc 600 ttcattaaaa taatcaatta ttgctttttt tgaaccaaat caaaaacgtt taattttctt 660 agtaaagtga taatcatcat ttctcacttt tttgtcaggt ggaattggct cataaaattg 720 aggtttagtt tgtatattaa tatcaccaat gtcatcaata actaagccta atttataatt 780 aatatcaaaa gtaccattat ttgaattttt atctgtattg taaattaaac taaaatcatt 840 taacttaaca tgatattttg cattatataa atttagtaaa gcaaaattat aagaataata 900 taaatacaag gagcgtttaa ttgtttgatc aaaataatct tttaaactct catagaggtt 960 tagaaaaatt ttagtttctt tattttgaga ttgatttaat atttgttttt catttgcaag 1020 attaatatta ttatttgtga ttgattgaaa cttgatttgc gtatcttgat taattgttac 1080 ttttttagat ttttttgttg aacaactagt taataaaact aaactaataa tagttgttaa 1140 taatatacta ataaagatta ttaatcttgc tttgagatta ctttttgttt tcat 1194 169 1736 DNA Ureaplasma urealyticum 169 tgagaaataa tttatctgat ttggaaatcg aaaaattgac caaaacatta gtatcaaaaa 60 acaaaagagt tgtagcttta tatggcgttc ccgaaaacac ttcttataaa ctaatgaacg 120 atctaattag tttaatggat gtagaaattc ctaattgatc atcaatttca agcgcaactg 180 aagaccaatg tattaatgat attaaaaatt ttttactgtc aaatgcaagt ttagaaaact 240 ttaaaaactt gccttctaat aaccctttaa ttaattggtg gaaaagacgc cgtttaaata 300 ctgttgttaa aaagattgaa gaaatcaact cagcgttcgc agaccgtgaa ataacatctc 360 gttcaaaaat ctttttgatg cctgttttaa cagcatttag tactttagga actacactag 420 ctgttccttt aatatctgtt acttttttac ggggtgatgc aattattaat ttgtggggta 480 aagatggata tattgctttc ttaagtttac tattttcttt agttgttgct gttattattt 540 cagcttttgt cgctttattt agtagtttaa aaaataataa acgtaattat attgtttcaa 600 acatgaccaa aggtcttaaa agaatatatg ataaatattt tatcgaaagt aattctcaag 660 aaaagattaa tgctaaagta actttttatt cacgcttttt agaacgttct aaattcgttg 720 ttcaaaataa ttacacattt ttttatgatg ttgtagatat taatagtgat caatatccta 780 aaatattaaa atatttcaaa accttaaacc aattaaataa tacagtaatc ttcgatgcta 840 gtggttttaa atatttagac gaacgtaaaa ttttccgtaa cattatcgat ttagagaaaa 900 caaatgttgt ccgtttggat cgttataaaa caaaaacaag cggacgtcgc ttaatgagtt 960 ttattttcta tcaattatca atcattgcta atgttaatac acgaaaactt ttacaaaaat 1020 ttcctttctt tgtcaactct ttatatcgtt ttttagatta cagcgaaaaa aatactgagt 1080 tattaacact tttattagac attaaaaaac acgcttcaaa aacagaaatt ccattaaacg 1140 atgaatcaca attatttttt gtagactttt ttacattcgt ggtttttaaa gctttggatg 1200 aattaggatt tgagacgcta atgaatgatt taacagtcta tggtcgtcca tctgaaatca 1260 ctaagaaaaa tataacttat aattcattaa aattggatta catcattaat cgtaatgcgc 1320 gtaattttgg acaacaagca ttattgttta acttattaga ttattttgat gagacagtaa 1380 ataaaaatat ctttaacgaa ttaggaaata gtaataaaaa catgattttt tctaaaaatc 1440 atcaattaaa tttagccaat gaagctttaa gtaaaaaagg ttttacaaag cgtgaaattg 1500 atttaaataa tcattgatat gatgctttat attctaatct tcatgatgat gaagacatgt 1560 ttgttaaaat tattgaaatt aaagataatg ttgatatctt aaatgtatta gatgaactct 1620 ttgttcgtgc tcaaaatgat ggtgttaaaa atttattaat ttatgttttt aatgtaaaaa 1680 tgttatattc attaatagat aatgaatacg agttggttaa tgagtcaatt atttaa 1736 170 1581 DNA Ureaplasma urealyticum 170 atgaaaagaa agaataaaat aataacatca tcattagctt tattgtttac aggagtaata 60 gcaacgataa gtattgccgc ttgctcaaaa caaaataatc aaaaaacaaa aaattttaat 120 tcacaagaac aagcaaataa gattattgag gctatattaa ataaaaaaga aggtaaggat 180 aattttatcg attgagttca ttgatgaaat agtccatttc aacaagcacg caaacttgca 240 aaagatttag ataaatatat tgatttaaca aaatctaaaa attttaaatc aatgattgat 300 aaaaatgaat ataagtcaac ttttagtgca caaattgaaa atgtaattag gatcattaaa 360 gatgatatta aaatgtatgc taattcacca ttttgaaaaa aatgacgcca gcaaaagaaa 420 acagcactat ttttaattaa ttatgcacct attcaaaaag atgatagcca aattaatgct 480 ccaggtattt tattacctgc tgaataccca ttattatatt ctaaacctga ttttgaagaa 540 ctaccaggat tcggtgcatt ttttcctaca ccaaaatcta tggatgcagt cgatctttta 600 gatacttgaa aatcgtttgg atcattaatt tcatctaaag gtaattctgt tgaaaaaagc 660 gttttagcat ctaaattaca aaattcattt gcaaaaacag cagataaagt tgtttacatt 720 tatgatgatg ctattgtccc taatatttat gataagaatg gcaatcgtaa tttaaaaatt 780 acacaagaat ttgctaattg aatgattaac caaaattata aaggttattt agctcgtgaa 840 tttttaaaaa taaatcaaaa aaatgattta attcctttac caatgagtat tgtttgacac 900 gcaagttatg gtatcatcgg aatgcatcgt atgttatata ctttatcaaa agcttttgga 960 atgccaaaag atgaattaga acatttgaaa gcacaagaaa aatttaaaat tccaacttta 1020 aaaaaattac taacaaatga tgaattagaa ttgaaaaatg gtatacaaac gattaaaaca 1080 ggcattgatt cgccatttaa atatcatcgc gatcaaaacc gtgatgattg aaaaatttga 1140 gcaactaatt cccaagtttt agatatttgt attgctttgg gtttaaaacc agatttatta 1200 gttaaaggcg aactatcaac tagtgtccat gaagatccta acttagctta ttatttaaat 1260 gatgtaataa aaaaccaatt aagtgatata gaacaaatta gtattaaaaa aaaccacatt 1320 aattgaacag caacaaatta tgaacctatt aaaaatttaa atgttaattt aattttaatg 1380 ggtgtgcatg gcttaattaa aaattcagct tttaaaaaaa tgatggatga aggtaaacaa 1440 attaaaaatt gggcctttac tgaccgcaga tttagcgatg aaacacgcca atatgttaaa 1500 aaaggtgaag aagatttata tagccaaaac gcatcaattc ttggttgaga tgagttttta 1560 aaaacgaaga acaatcaata a 1581 171 501 DNA Ureaplasma urealyticum 171 atggttaatg acaaaaaaca aaaatcaaat aaatatttaa cgtaccaaga tcaagaatat 60 gaacgtaatc ttttattaga aaaagaacgt aaacaacaaa aaaagatttt ggcacaacaa 120 gcatatcaac aattagatct taataaaaaa ttaattaaaa aagctaaaaa tgatcaaaaa 180 cttattttaa gactactaaa agaagataaa tcaatttcaa aaacacaatt taatacccac 240 cgtttagaat taaaaaatac aattgatcaa atggttgatg aatattatga attattagaa 300 caatatagtg tagattttga aaaaataagt tttaaattaa aacgttggct ctatggcatt 360 aataaagaaa tcagacgtac tacttgggct tctaaacgtt ctgttattat cagtttaatc 420 attgtaattg ttattgtttt aattcttgct gcaatatttt ttggtattga tacaggtttt 480 tataaattat cagcaaaata a 501 172 720 DNA Ureaplasma urealyticum 172 ttaatttatt aattttgaat ttttaataaa ttgataaata cgattaatgt atttgggata 60 aattgtgttt tgcttagcta attttttatc taataacacc aaatctaatt ggcaatcttt 120 atatttatta aaaagataat catctatttg atataactca ttaacacata aaatatggtc 180 gcttgaagcg catgcaagac gttttaaatc ctgtgtaatt ttattactat tgtaatcttt 240 tggaatttca gatattacac taacattgca gtaacttaag tatttaatgt ttttagaact 300 atagattccc tcatctgtga tgatacatat tctagcttta agagaaatta aacgattgat 360 aagtgtgtcc aaaacaacac tatcataata aataacaaat ccatatcctg cttttatcaa 420 ggttagtata tcataatttg atattgcatt ttcataatct attaaccaaa tatttttttt 480 atcaagtcat tcaactgttg ttgaataata taaaataaaa ggaggttggt taattttttt 540 atatttatta ggatattttt catcagttaa atcaatagct ttaacttttt cgtaatcttc 600 tttttctaaa aataaatatt cattttgatc ttcatgattt attaatgcta aataaatttt 660 tgatcaatcc cctttatact tcaaactgaa atagtgtgtt aaataattca atggtatcac 720 173 441 DNA Ureaplasma urealyticum 173 ctacacatac tcattaaaag atattaaata tttataaatt tgtttttgtt gatattgaat 60 tttttgtctt atattaaatg tataataagc taatctaaaa aaaataaaag gaagattttt 120 gatcggtttt ttcggtgggt atttattgat ttttaaaatt aaatatcttg ctgtgctatt 180 atgacaattg atccataaaa gataaattat tgtaataaat aacattaaaa aactaataca 240 tgttaaaatt gtaaaatcta aatatttttt ataatttaat aatttttcat tatatccata 300 atttaaagct aaaattaaat ttgtgataaa agaaattaat caaccagcta aaaatatact 360 aataaaaact ccaataaatt tatatttaaa atataattta cctatcaaat aatcttttaa 420 ttcttctaaa actattttca a 441 174 513 DNA Ureaplasma urealyticum 174 ttatttttct tcttcaactt tcatttgctt taaatattta cgaatggcat attcaacttg 60 caaattatta gtagcatttt caaagaaatc atggatggta cgaacatcat caaaatcttt 120 aataccatca tcaacaaatc attttacaaa actaaatgtt tcaaaatcat tttcttccaa 180 acatactttt gccatattgg ctacatgctt acgaactttt aattctgtat ctaaaatgtg 240 ttttattaat tccttaggat tcgctggctt aaaattaaca tctacactaa atttagtgtg 300 taatggaatt tcaactttac gagcatattc agaaattaaa ttcttgtgaa cacctaattt 360 atcattgctt aaatcagcaa taaattttgc taaaaaaggc atactgaatt ggtcatcagc 420 aatatgagca tattgtgcat aaatactacc tagttctaaa tttaaattat aatgtgtatt 480 taaaacatct ataacttttt gagatttaac cat 513 175 864 DNA Ureaplasma urealyticum 175 ttatggtttt cgtaaaatta aaggtttttt attgaataat tttcttctaa aataatcatg 60 agcaacagca ttaatttttt caacatgata ataagtatta gctaaaactc gtaatcccaa 120 accaggaata tccatacgtg atacaccaaa tatcatatcc atgtcaggat atttttcctt 180 aactaaatca cgaattttaa taacatcatc ttcaataact tgttgattaa ttacaatcat 240 ggttccacaa taatgatagc catccatgat tccaaatgct gattcatcat ttttacgtgg 300 ttgaaatttt aaattatcaa ataaaaccaa tttatcatca taatatattt tagtatttaa 360 atacattttt tcgtattgat aagcagaccc atgtggcgat caaccagggc caaaacattc 420 tgtgtaaatt aaagtagcac ttgaatccat tttaaaatta ttaaattgtg cgaactttcc 480 atcttcataa acaattacgt tatcacttat atattctaaa atactatttt ttcctaacgt 540 gatatttgta tgttgctcag aagtttttcc atcaaccgtt ttataagctt tagctgagga 600 ttgtgttgta atgatacaac gagcatcatc attaatttca aaatcagaac gataaatttc 660 acctgaaaca tatccaccac ccatactaat tgtttgaaaa caggggttga ttggatcttc 720 ttcatctaaa aataaaggtt tagatgaacg ataaaaattc gtaaaataga cagtatgtgc 780 catttttgaa tgagcttgat catatgctac tttaatgtat aaataagcag cataattttt 840 aattttttct ttatttaaaa tcat 864 176 621 DNA Ureaplasma urealyticum 176 ttattcttct agtaaagcta attgcaaacg cttttcaatt caatcagcaa cagattttaa 60 accttcatct gtttttaaat tcgttacaaa gaaatcttta ttaccacgtg attttaatgt 120 atcggctttc attacttcta cattagcacc aacataagga gctaaatcaa ctttattaat 180 aataaataag tctgatttaa tcattccttg accaccctta cgaggaattt tttctccttg 240 tgcaacatca atgatataaa ttgaaaaatc aactaaatct ggactaaatg ttgcagataa 300 attatcccca ccagattcta aaaataataa ttgtaaatca gggtgtttat cacacatttc 360 ttcaattgca gcaaagttca ttgaagcatc ttcacgaatt gctgtatgtg gacatcctcc 420 tgtttcaaca ccagcaatac gatcagctgg taaaacagaa gtatttaata aaattctagc 480 atcttcttta gtgtaaatat cattagtaat tgctgccata ctataacctt ttgttgaaag 540 gtatcttgtt aatctttcga ttagcattgt tttacctgct cctacaggtc cacctacacc 600 aataattaat ggtcttttca t 621 177 753 DNA Ureaplasma urealyticum 177 ttatgacatg aataatcgaa caggtgtgtc ttcgtgttcc atttgtgcaa tttcaaggcc 60 tggtatattt ttgcaaaaat ctgttttaaa atccaatgta aagactttat taacaatatc 120 atcaaaataa acatgtttaa gttgataaat tattttttgt cccttaactt gtcctaatgg 180 aattgcacgt acacagtttt gcgttaatgc agcaactgta gagtaaagat gcgtatataa 240 agcagttttt aaatctattt ttaaatgcat agctaataaa gcaaacgcaa cagcaggatt 300 tccataagat tttttatttt ttattctttc agcatattca actaaaagtt cacaattaaa 360 aagttcatta tatatcttta ccatttgttg tccaattcga cgttgacctt cacgagtctc 420 tcttgctaaa ccttgaaagt ttatcatttg atcaatttct caaattgcat ttattttttg 480 ttttggcaat agtttaaaaa tttgataaat tgccaataaa tcaccatgta acaattgttc 540 attcatatac agaagtaacg ctttaattaa tgattctcca tcaaaaacaa tatcttttct 600 aatataagtt tcaactccaa aagaatgact aaatgttcca attggaaagt ttgcgttagt 660 gatctgcatt aggtctaata aatttaaata gtcactattt agcgtcacta cagtgtttaa 720 atgcttcttt aagtttaatt ttttttcttt cat 753 178 450 DNA Ureaplasma urealyticum 178 ctatttagcg tcactacagt gtttaaatgc ttctttaagt ttaatttttt ttctttcata 60 tagggcttta ttatcttgaa ggtattcttc tactaaatag tcgtagggaa cgatcatttg 120 tgtttcagta aattgagccg gcatatgacg attacctaaa ttatgggcaa tttttgccat 180 ttcaccaatt gtgtgtgctg taataattaa tacatctgat aactctaatc taataacaac 240 tagtttataa tcatccttgt ataagatgtc accatccatt aattttttgt cctcttctaa 300 acgaattcca tattcaacat tttgatctga tgaaatgata attacacgtt ttaaaacgtc 360 gtcgcttgtt aaatgaatgt tctcaatttg ataactttca acatttttaa tgttagcaat 420 attatctaaa atttctttaa atacagtcaa 450 179 1797 DNA Ureaplasma urealyticum 179 ttaaaataag aaatatcttt gtgctaatgg cgcttctgtt aaaggttcag catcaagtat 60 atatttgcca cttgaagtct tttttaattt tttagctaat tcagaagctg attgttctag 120 tcaattttct aaatcattaa aatcaacagc agcatcaaaa gtttgcggat caacttctaa 180 atttggagtc gcagagtttc atttcatact ctttttattt actgaacggc aatttttaac 240 tggtaataat tctttttcta atttatattc ctctttaatg ccattttcta acccaatttt 300 tgaaacaaaa cttactgatg tattagttaa caaacgtcca taagttccaa attggtcacg 360 cataattaca ggttcgcatg ttggaattga agcatttgga tcacctgcta cacaacgagc 420 gattacaccc atttttacaa cataataagg ttttgcacca aagaatttag gttctcaagc 480 aacaatatca gctaatttac caacttctag tgaaccaata taagaatcaa caccatgtgc 540 aatagctggg ttaattgtat atttagaaat ataacgtttt acacgattgt tatcactgaa 600 ttcactatca ccttttaatg atccaaattg tgctttcatt ttgtgagcca tttgtcatgt 660 acgagttgca acttcgccaa tacgtcccat agctaatgta tctgatgaca taattgaaat 720 tgcacccata tcgtgcaata agtcttcagc tgcaattgtt tggctacgaa tacgtgaatc 780 agcaaaagca acatcttctg gaaccttagg atttaagtgg tgacatacca ttaacatatc 840 taaatgttca gcaattgtat ttactgtata aggaattgtt gggtttgtag aagctggtaa 900 aatatgggca tatttaacag tttctagaat atctggagca tgccctccac cagcaccttc 960 tgtatgataa gcatgaattg ttcgcccttt catagctgca attgtatgtt ctacaaatcc 1020 agcttcattt aatgtatctg tatgaatagc aacagctaca tcagttttat cagcaactgt 1080 taatgctaaa tcaatcgcat ttcctgttgc ccctcagtct tcatggattt taagtccaca 1140 agctccagca gcaatttgct caaaaattgg atcttccata ccttgacctt tagctaaaaa 1200 accggcatta attgataatc catcagctgc ttgtaaagct gatttaactc aaaatttacc 1260 aggtgaaaca gttgtggctt ttgtaccatc attcatacct gtaccaccag caataacagt 1320 tgtaatacca ccatctaatg caacaggaac tatttctggt tctagtcagt gaacgtgagt 1380 atctaaacca ccagctgtat aaattttacc ctcaccagct gaaatttcag ttgagatacc 1440 cacaatcata tcaacattat ctgttaaatg tggatttcca gatttaccaa tcgcagcaat 1500 ttttccattt ttaataccaa tatctgcttt ataaatacct gtataatcaa caattagtgc 1560 atttgtaata actaaatcca ttacttcagc attacctaat ttatcatcta acttcatagt 1620 agaattcatt cccatacctt cacgtagggt ttttccacca ccaaaaacag attcttcacc 1680 ataagtagtt aagtcttttt caactttaac tcaaagattt gtatctccta atctaacgct 1740 atcaccagtt gtaataccgt ataaatctga ataatttttt cttgaaattt taaacat 1797 180 375 DNA Ureaplasma urealyticum 180 ttatttttta agttttccat taactaagcc atttacacct caaacttcgc gtgttccggc 60 taaatcaata attgaaactt cttttttatc tcctggttca aaacgaatag cagtacctga 120 tggaatatcg aaacgtcgtc cataagcaac tttgcgttct ttatcttcat ttcctttttc 180 atcaaaaaat actaatgcac tattcacttc aaacaagtga aaatgtgatc caacttgtat 240 aggacggtcc ccagtatttt taatactaat tacttttgcc tctctacctt cattcatcac 300 aatttcacca ctagcgaaat taattgcccc tggtactaat ttacctggac taaattgact 360 tgatgatcct gacat 375 181 306 DNA Ureaplasma urealyticum 181 ttatttgtaa attggatcgt gtacagaaac tagtttagta ccatcaggga aagtaacttc 60 aacttgaatt atactaacca ttgtatctac accttccata acttgatcaa cacgtagtac 120 ttcacgagca gattgcatta ggtcagcaac tagcttacca tctcttgccc cttccattac 180 atgatcagta attaaagcaa cagcttctga atagtttaat tttaaacctc tagctaaacg 240 tcttcttgca acgtcagcag caactgttat caataatttt tggacttctc ttaatgatag 300 attcat 306

Claims (1)

1. A polypeptide product and biologically active variants thereof of the expression in a prokaryotic or eukaryotic host cell of a nucleotide sequence selected from the group consisting of SEQ ID No:60.
US10/349,680 1998-01-30 2003-01-23 Nucleic acid probes and method for detecting ureaplasma urealyticum Abandoned US20030176654A1 (en)

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WO2013165537A1 (en) * 2012-05-03 2013-11-07 The Government Of The Usa As Represented By The Secretary Of The Department Of Health And Human Services Real-time pcr for the detection of pathogens
CN103966315A (en) * 2014-03-25 2014-08-06 浙江大学 Fluorescence quantitative PCR (polymerase chain reaction) detection method for 14 serotypes of Uu (ureaplasma urealyticum)
CN103882133A (en) * 2014-03-31 2014-06-25 深圳意达凯生物科技有限公司 Primer pair for detecting ureaplasma urealyticum, kit and application thereof
ES2767527T3 (en) * 2014-06-30 2020-06-17 Univ Hong Kong Chinese Detection of bacterial taxa to predict adverse pregnancy outcomes
CN110257534A (en) * 2019-04-22 2019-09-20 深圳市国赛生物技术有限公司 Ureaplasma urealyticum kit for detecting nucleic acid

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