US20010007669A1 - Novel formulations comprising lipid-regulating agents - Google Patents
Novel formulations comprising lipid-regulating agents Download PDFInfo
- Publication number
- US20010007669A1 US20010007669A1 US09/330,588 US33058899A US2001007669A1 US 20010007669 A1 US20010007669 A1 US 20010007669A1 US 33058899 A US33058899 A US 33058899A US 2001007669 A1 US2001007669 A1 US 2001007669A1
- Authority
- US
- United States
- Prior art keywords
- lipid
- regulating agent
- particles
- fenofibrate
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Definitions
- the present invention relates to novel formulations comprising lipid-regulating agents.
- 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethylester, also known as fenofibrate, is representative of a broad class of compounds having pharmaceutical utility as lipid regulating agents. More specifically, this compound is part of a lipid-regulating agent class of compounds commonly known as fibrates, and is disclosed in U.S. Pat. No. 4,058,552.
- Fenofibrate has been prepared in several different formulations, c.f., U.S. Pat. No. 4,800,079 and U.S. Pat. No. 4,895,726.
- U.S. Pat. No. 4,895,726 discloses a co-micronized formulation of fenofibrate and a solid surfactant.
- U.S. Pat. No. 4,961,890 discloses a process for preparing a controlled release formulation containing fenofibrate in an intermediate layer in the form of crystalline microparticles included within pores of an inert matrix.
- the formulation is prepared by a process involving the sequential steps of dampening said inert core with a solution based on said binder, then projecting said fenofibrate microparticles in a single layer onto said dampened core, and thereafter drying, before said solution based on said binder dissolves said fenofibrate microparticles, and repeating said three steps in sequence until said intermediate layer is formed.
- European Patent Application No. EP0793958A2 discloses a process for producing a fenofibrate solid dosage form utilizing fenofibrate, a surface active agent and polyvinyl pyrrolidone in which the fenofibrate particles are mixed with a polyvinyl pyrrolidone solution. The thus obtained mixture is granulated with an aqueous solution of one or more surface active agents, and the granulate thus produced is dried.
- PCT Publication No. WO 82/01649 discloses a fenofibrate formulation having granules that are comprised of a neutral core that is a mixture of saccharose and starch.
- the neutral core is covered with a first layer of fenofibrate, admixed with an excipient and with a second microporous outer layer of an edible polymer.
- U.S. Pat. No. 5,645,856 describes the use of a carrier for hydrophobic drugs, including fenofibrate, and pharmaceutical compositions based thereon.
- the carrier comprises a digestible oil and a pharmaceutically-acceptable surfactant component for dispersing the oil in vivo upon administration of the carrier, which comprises a hydrophilic surfactant, said surfactant component being such as not to substantially inhibit the in vivo lipolysis of the digestible oil.
- Gemfibrozil is another member of the fibrate class of lipid-regulating agents.
- U.S. Pat. No. 4,927,639 discloses a disintegratable formulation of gemfibrozil providing both immediate and sustained release, comprising a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach.
- the first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative
- the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically-acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically-acceptable (meth)acylate copolymer prior to admixture with the first granulation.
- the first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
- U.S. Pat. No. 4,925,676 discloses a disintegratable gemfibrozil tablet providing both immediate and enteric release, which is compressed from a mixture of a first granulation of gemfibrozil with at least one acid-disintegratable binder, and a second granulation formed from the first granulation, but regranulated or coated with an alkali-disintegratable formulation of at least one substantially alkali-soluble and substantially acid-insoluble polymer.
- statins Another class of lipid-regulating agents are commonly known as statins, of which pravastatin and atorvastatin are members.
- U.S. Pat. Nos. 5,030,447 and 5,180,589 describe stable pharmaceutical compositions, which when dispersed in water have a pH of at least 9, and include a medicament which is sensitive to a low pH environment, such as prevastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as microcrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.
- prevastatin one or more fillers such as lactose and/or microcrystalline cellulose
- binders such as microcrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder)
- the present invention is directed to a process for preparing formulations comprising lipid-regulating agents with enhanced dissolution and absorption characteristics. More particularly, the process comprises dissolving the lipid-regulating agent in a supercritical fluid, spraying the supercritical fluid through a nozzle to form small particles comprising said lipid-regulating agent, forming a suspension of said lipid-regulating agent in a liquid in which the particles are insoluble and collecting said particles. The particles then be spray dried or lyophilized. They may optionally also be cooled with pharmaceutically-acceptable excipients, such as, for example, surfactants, polymers, lipids or other materials.
- pharmaceutically-acceptable excipients such as, for example, surfactants, polymers, lipids or other materials.
- the resulting formulation results in an increase in drug solubility and oral bioavailability, and an improved dissolution rate.
- the formulation may be administered directly, diluted into an appropriate vehicle for administration, encapsulated into hard gelatin capsules for administration, or administered by other means obvious to those skilled in the art.
- FIG. 1 is a graph showing the dissolution characteristics of fenofibrate nanocrystals or nanoparticles produced by the process of the present invention and reference compositions.
- the bulk lipid-regulating agent may be prepared by any available method, as for example the compound fenofibrate may be prepared by the procedure disclosed in U.S. Pat. No. 4,058,552, or the procedure disclosed in U.S. Pat. No. 4,739,101, both herein incorporated by reference.
- the term “supercritical fluid” means a substance, such as for example carbon dioxide, which becomes a liquid state when its pressure and temperature are greater than its critical pressure and critical temperature, respectively.
- nozzle means a device through which a liquid is forced out under high pressure to become very fine (micronized) droplets.
- the composition comprising the lipid-regulating agent may be prepared by using a SFX 220 supercritical particle generator, which consists of an ISCO extractor, controller, one or more D series syringe pumps, and a temperature controlled variable restrictor.
- the extractor incorporated six motor actuated valves that are controlled by the controller.
- the controller executes the process program and displays real-time data.
- the fluid source for the extractor is supplied by a unique syringe-type pump that maintains a constant process pressure in the extractor and up to the restrictor.
- the lipid-regulating agent nanocrystals or nanoparticles are prepared by a process in which the drug is solubilized in the extractor at 50° C. and 2000 psi with carbon dioxide for a period of one to five minutes. The solutions are then released through a temperature controlled restrictor. Drug particles form when the carbon dioxide is vaporized. Particle size can be controlled by varying the concentration of the solution and/or by the process flow rate.
- Sub-micron particle size can be achieved either by using a very dilute solution or by adding additional liquid carbon dioxide through a second syringe pump to the outlet and before the restrictor.
- Surface coating meterials such as phospholipids, surfactants, and/or polymers, may also be added either before or after particle formation to change properties of the surface of the sub-micron particles, as desired.
- the materials can be coated on the surface of these tiny particles in the process to become coated nanocrystals or nanoparticles, which can prevent from the growth or aggregation of particles.
- Representative particle size stabilizers include, for example, sodium lauryl sulfate (SLS) or sodium dodecylsufate (SDS) (BDH Laboratory Supplies), gelatin (Sigma), casein (Aldrich), lecithin (Sigma) and any phospholipids, gum acacia (TIC Gums), cholesterol (Aldrich), tragacanth (Sigma), stearic acid (Sigma), benzalkonium chloride (Sigma), calcium sterarate (Penta Manufacturing Company), glyceryl monostearate (ABITEC), cetostearyl alcohol (Croda), cetomarogol emulsifying wax (Croda), sorbitan esters (Uniqema), polyethylene glycols (Union Carbide), polyoxyethylene stearates (Uniqema), colloidal silicon dioxide (Cabot), phosphates (Sigma), caboxylmethylcellulose calcium (Kraft), carboxymethylcellulose sodium (Aldrich),
- compositions of the present invention are those which are conventionally used in oil-based drug delivery systems, e.g. antioxidants such as tocopherol, tocopherol acetate, ascorbyl palmitate; ascorbic acid, butylhydroxytoluene, butylhydroxyanisole and propyl gallate; pH stabilisers such as citric acid, tartaric acid, fumaric acid, acetic acid, glycine, arginine, lysine and potassium hydrogen phosphate; thickeners/suspending agents such as hydrogenated vegetable oils, beeswax, colloidal silicon diocide, gums, celluloses, silicates, bentonite; flavouring agents such as cherry, lemon and aniseed flavours; sweeteners such as aspartame, saccharin and cyclamates; etc.
- antioxidants such as tocopherol, tocopherol acetate, ascorbyl palmitate; ascorbic acid, butylhydroxytoluene, butylhydroxyanisole and
- the particles comprising the lipid-regulating agent produced by the process of the present invention are preferable less than 5000 nm in diameter, more preferably less than 1000 nm in diameter.
- the delivery system of the present invention results in an increased dissolution rate which improves bioavailability of the lipid-regulating agent.
- the resulting composition comprising the lipid-regulating agent may be dosed directly for oral administration, diluted into an appropriate vehicle for oral administration, filled into hard gelatin capsules for oral administration, or delivered by some other means obvious to those skilled in the art.
- the said composition may be used to improve the dissolution rate, and the oral bioavailability, and increase the half-life of said lipid-regulating agent.
- Fenofibrate 100 mg was added into a 10 mL cartridge in a critical fluid extractor.
- the cartridge was processed with 50 mL liquid carbon dioxide, which was heated and pressurized above its critical temperature and pressure.
- Fenofibrate was dissolved/finely dispersed in the supercritical carbon dioxide fluid.
- the outlet restrictor was adjusted to deliver the desire flow rate.
- the supercritical fluid containing solubilized/finely dispersed fenofibrate was filtered through a submicron pore sized filter, and then sprayed out through a nozzle.
- Liquid carbon dioxide became gas and submicron particles or nanoparticles dropped out.
- the particle size was determined using a API Particle Sizer.
- the particles may optionally be filled into capsules in a quantity appropriate to obtain the desired dose.
- the process parameters were: Static Parameters: 1. Time 1 minutes (range 1 to 10 minutes) (based on solubility) 2. Pressure 2000 psi 3. Temperature 50° C. Dynamic Parameters: 1. Pressure 2000 psi 2. Temperature 50° C. 3. Time 10 minutes 4. Volume 50 mL 5. Flow rate 10 mL/min (range 1 to 20 mL/min)
- Example 1 The method used in Example 1 to generate fenofibrate nanoparticles was limited to a small scale because of equipment capability.
- Formulation 1 Fenofibrate 10 g Sodium Lauryl Sulfate 1 g
- Formulation 2 Fenofibrate 10 g Pluronic F127 1 g
- Formulation 3 Fenofibrate 10 g Gelucire 53/10 1 g
- the equipment used in the milling process including:
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
- The present invention relates to novel formulations comprising lipid-regulating agents.
- 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethylester, also known as fenofibrate, is representative of a broad class of compounds having pharmaceutical utility as lipid regulating agents. More specifically, this compound is part of a lipid-regulating agent class of compounds commonly known as fibrates, and is disclosed in U.S. Pat. No. 4,058,552.
- Fenofibrate has been prepared in several different formulations, c.f., U.S. Pat. No. 4,800,079 and U.S. Pat. No. 4,895,726. U.S. Pat. No. 4,895,726 discloses a co-micronized formulation of fenofibrate and a solid surfactant.
- U.S. Pat. No. 4,961,890 discloses a process for preparing a controlled release formulation containing fenofibrate in an intermediate layer in the form of crystalline microparticles included within pores of an inert matrix. The formulation is prepared by a process involving the sequential steps of dampening said inert core with a solution based on said binder, then projecting said fenofibrate microparticles in a single layer onto said dampened core, and thereafter drying, before said solution based on said binder dissolves said fenofibrate microparticles, and repeating said three steps in sequence until said intermediate layer is formed.
- European Patent Application No. EP0793958A2 discloses a process for producing a fenofibrate solid dosage form utilizing fenofibrate, a surface active agent and polyvinyl pyrrolidone in which the fenofibrate particles are mixed with a polyvinyl pyrrolidone solution. The thus obtained mixture is granulated with an aqueous solution of one or more surface active agents, and the granulate thus produced is dried.
- PCT Publication No. WO 82/01649 discloses a fenofibrate formulation having granules that are comprised of a neutral core that is a mixture of saccharose and starch. The neutral core is covered with a first layer of fenofibrate, admixed with an excipient and with a second microporous outer layer of an edible polymer.
- U.S. Pat. No. 5,645,856 describes the use of a carrier for hydrophobic drugs, including fenofibrate, and pharmaceutical compositions based thereon. The carrier comprises a digestible oil and a pharmaceutically-acceptable surfactant component for dispersing the oil in vivo upon administration of the carrier, which comprises a hydrophilic surfactant, said surfactant component being such as not to substantially inhibit the in vivo lipolysis of the digestible oil.
- Sheu, M. T., et al,Int. J. Pharm. 103 (1994) 137-146, reported that a dispersion of fenofibrate in PVP still maintains the same crystalline form of the drug itself.
- Palmieri, G. F., et al,Pharma Sciences 6 (1996) 188-194, reported that a dispersion of crystalline fenofibrate could be prepared in PEG 4000. However, dissolution of the composition was poor.
- Gemfibrozil is another member of the fibrate class of lipid-regulating agents. U.S. Pat. No. 4,927,639 discloses a disintegratable formulation of gemfibrozil providing both immediate and sustained release, comprising a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach. The first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative, and the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically-acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically-acceptable (meth)acylate copolymer prior to admixture with the first granulation. The first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
- U.S. Pat. No. 4,925,676 discloses a disintegratable gemfibrozil tablet providing both immediate and enteric release, which is compressed from a mixture of a first granulation of gemfibrozil with at least one acid-disintegratable binder, and a second granulation formed from the first granulation, but regranulated or coated with an alkali-disintegratable formulation of at least one substantially alkali-soluble and substantially acid-insoluble polymer.
- Another class of lipid-regulating agents are commonly known as statins, of which pravastatin and atorvastatin are members. U.S. Pat. Nos. 5,030,447 and 5,180,589 describe stable pharmaceutical compositions, which when dispersed in water have a pH of at least 9, and include a medicament which is sensitive to a low pH environment, such as prevastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as microcrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.
- It is an object of the present invention to provide formulations of lipid-regulating agents having enhanced bioavailability when compared to commercially available formulations.
- The present invention is directed to a process for preparing formulations comprising lipid-regulating agents with enhanced dissolution and absorption characteristics. More particularly, the process comprises dissolving the lipid-regulating agent in a supercritical fluid, spraying the supercritical fluid through a nozzle to form small particles comprising said lipid-regulating agent, forming a suspension of said lipid-regulating agent in a liquid in which the particles are insoluble and collecting said particles. The particles then be spray dried or lyophilized. They may optionally also be cooled with pharmaceutically-acceptable excipients, such as, for example, surfactants, polymers, lipids or other materials.
- The resulting formulation results in an increase in drug solubility and oral bioavailability, and an improved dissolution rate.
- The formulation may be administered directly, diluted into an appropriate vehicle for administration, encapsulated into hard gelatin capsules for administration, or administered by other means obvious to those skilled in the art.
- FIG. 1 is a graph showing the dissolution characteristics of fenofibrate nanocrystals or nanoparticles produced by the process of the present invention and reference compositions.
- The bulk lipid-regulating agent may be prepared by any available method, as for example the compound fenofibrate may be prepared by the procedure disclosed in U.S. Pat. No. 4,058,552, or the procedure disclosed in U.S. Pat. No. 4,739,101, both herein incorporated by reference.
- As used herein, the term “supercritical fluid” means a substance, such as for example carbon dioxide, which becomes a liquid state when its pressure and temperature are greater than its critical pressure and critical temperature, respectively.
- As used herein, the term “nozzle” means a device through which a liquid is forced out under high pressure to become very fine (micronized) droplets.
- The composition comprising the lipid-regulating agent may be prepared by using a SFX 220 supercritical particle generator, which consists of an ISCO extractor, controller, one or more D series syringe pumps, and a temperature controlled variable restrictor. The extractor incorporated six motor actuated valves that are controlled by the controller. The controller executes the process program and displays real-time data. The fluid source for the extractor is supplied by a unique syringe-type pump that maintains a constant process pressure in the extractor and up to the restrictor.
- The lipid-regulating agent nanocrystals or nanoparticles are prepared by a process in which the drug is solubilized in the extractor at 50° C. and 2000 psi with carbon dioxide for a period of one to five minutes. The solutions are then released through a temperature controlled restrictor. Drug particles form when the carbon dioxide is vaporized. Particle size can be controlled by varying the concentration of the solution and/or by the process flow rate.
- Sub-micron particle size can be achieved either by using a very dilute solution or by adding additional liquid carbon dioxide through a second syringe pump to the outlet and before the restrictor.
- Surface coating meterials, such as phospholipids, surfactants, and/or polymers, may also be added either before or after particle formation to change properties of the surface of the sub-micron particles, as desired. The materials can be coated on the surface of these tiny particles in the process to become coated nanocrystals or nanoparticles, which can prevent from the growth or aggregation of particles. Representative particle size stabilizers include, for example, sodium lauryl sulfate (SLS) or sodium dodecylsufate (SDS) (BDH Laboratory Supplies), gelatin (Sigma), casein (Aldrich), lecithin (Sigma) and any phospholipids, gum acacia (TIC Gums), cholesterol (Aldrich), tragacanth (Sigma), stearic acid (Sigma), benzalkonium chloride (Sigma), calcium sterarate (Penta Manufacturing Company), glyceryl monostearate (ABITEC), cetostearyl alcohol (Croda), cetomarogol emulsifying wax (Croda), sorbitan esters (Uniqema), polyethylene glycols (Union Carbide), polyoxyethylene stearates (Uniqema), colloidal silicon dioxide (Cabot), phosphates (Sigma), caboxylmethylcellulose calcium (Kraft), carboxymethylcellulose sodium (Aldrich), methyl cellulose (Sigma), hydroxypropylmethycellulose phthaltate (Sigma), Microcrystalline cellulose (FMC), magnesium aluminum silicate (R. T. Vanderbilt), triethanolamine (Sigma), polyvinyl alcohol (Aldrich), PEG-2 stearate (Goldschmidt Chemical), PEG-stearate and gylcol stearate (Uniqema), PEG-6-32 stearate (Gattefosse), Gelucire 53/10 (Gattefosse), PEG-6 stearate (Protameen Chemicals), PEG-6 stearate and glyceryl stearate and ceteth-20 (Gattefosse), glyceryl stearate and PEG-75 stearate (Goldschmidt Chemical), hydrogenated palm oil/palm kernel oil PEG-6 complex (California Oils Corporation), glyceryl stearate and PEG-100 stearate (Uniqema), isoceteth-20 (Uniqema), PEG-6 sorbitan beeswax (Nikko Chemical),
PEG 20 sorbitan beeswax (Nikko Chemical), Ceteth-10 (Protameen Chemicals), Cetech-20(Protameen Chemicals), Ceteareth-20 (Protameen Chemicals), Stearate-2 (Protameen Chemicals), Steareth-10 (Protameen Chemicals), Stearate-20 (Protameen Chemicals), stearate-100 (Uniqema), Pluronic F127 (BASF) and polyvinylpyrrolidone (BASF). - Other optional ingredients which may be included in the compositions of the present invention are those which are conventionally used in oil-based drug delivery systems, e.g. antioxidants such as tocopherol, tocopherol acetate, ascorbyl palmitate; ascorbic acid, butylhydroxytoluene, butylhydroxyanisole and propyl gallate; pH stabilisers such as citric acid, tartaric acid, fumaric acid, acetic acid, glycine, arginine, lysine and potassium hydrogen phosphate; thickeners/suspending agents such as hydrogenated vegetable oils, beeswax, colloidal silicon diocide, gums, celluloses, silicates, bentonite; flavouring agents such as cherry, lemon and aniseed flavours; sweeteners such as aspartame, saccharin and cyclamates; etc.
- The particles comprising the lipid-regulating agent produced by the process of the present invention are preferable less than 5000 nm in diameter, more preferably less than 1000 nm in diameter.
- The delivery system of the present invention results in an increased dissolution rate which improves bioavailability of the lipid-regulating agent.
- The resulting composition comprising the lipid-regulating agent may be dosed directly for oral administration, diluted into an appropriate vehicle for oral administration, filled into hard gelatin capsules for oral administration, or delivered by some other means obvious to those skilled in the art. The said composition may be used to improve the dissolution rate, and the oral bioavailability, and increase the half-life of said lipid-regulating agent.
- The invention will be understood more clearly from the following non-limiting representative examples:
- Fenofibrate (100 mg) was added into a 10 mL cartridge in a critical fluid extractor. The cartridge was processed with 50 mL liquid carbon dioxide, which was heated and pressurized above its critical temperature and pressure. Fenofibrate was dissolved/finely dispersed in the supercritical carbon dioxide fluid. The outlet restrictor was adjusted to deliver the desire flow rate. The supercritical fluid containing solubilized/finely dispersed fenofibrate was filtered through a submicron pore sized filter, and then sprayed out through a nozzle. Liquid carbon dioxide became gas and submicron particles or nanoparticles dropped out. The particle size was determined using a API Particle Sizer. The particles may optionally be filled into capsules in a quantity appropriate to obtain the desired dose.
- The equipment used in the experiment included:
- 1. Isco Controller, Model SFX 200
- 2. Isco Supercrtical Fluid Extractor, Model SFX 220
- 3. Isco Syringe pump, Model 260D
- 4. Isco Restrictor Temperature Controller
- 5. Lauda Chiller, Model K2/RD
- 6. Mettler Balcance,
Model AE 100 - 7. API Particle Sizer, Model Aerosizer LD
- The process parameters were:
Static Parameters: 1. Time 1 minutes (range 1 to 10 minutes) (based on solubility) 2. Pressure 2000 psi 3. Temperature 50° C. Dynamic Parameters: 1. Pressure 2000 psi 2. Temperature 50° C. 3. Time 10 minutes 4. Volume 50 mL 5. Flow rate 10 mL/min (range 1 to 20 mL/min) -
Pravastatin 100 mg - Carbon dioxide (Liquid) 50 mL
- Applying the general procedure of Example 1 one may obtain Pravastatin nanoparticles.
- The method used in Example 1 to generate fenofibrate nanoparticles was limited to a small scale because of equipment capability.
- The following formulations were used to generate larger quantity of fenonfibrate nanocrystals/nanoparticles using a milling process.
- Formulations:
Formulation 1: Fenofibrate 10 g Sodium Lauryl Sulfate 1 g Formulation 2: Fenofibrate 10 g Pluronic F127 1 g Formulation 3: Fenofibrate 10 g Gelucire 53/10 1 g - These three formulations were prepared using three different particle size stabilizers—Sodium Lauryl Sulfate, Pluronic F127 and Gelucire 53/10. Each formulation was milled in water to the desire particle size and each suspension was filtered through a 1 micron filter to remove large particles. Each formulation was further processed using either a lyophilizing process or sprayed drying procedure to remove the milling media. The collected particles may optionally be filled into capsules in a quantity appropriate to obtain the desired dose.
- The equipment used in the milling process including:
- 1. DYNO-MILL, model KDL
- 2. Peristaltic Pump
- 3. 0.6 L Jacked Glass Chamber
- 4. Lead Free Glass beads 0.5 mm (GlenMills Inc.)
- The process parameters in the milling are listed below
Mill Speed 2000-4500 rpm Temperature 5-25° C. Pump Rate 20-200 ml/min - A dissolution study was conducted to observe the dissolution rates of three types of nanoparticles/nanocrystal formuolations generated in Example 3 and with that of a commercial formulation, Lipanthyl (Fournier SA). The results are illustrated in FIG. 1 below.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/330,588 US6368620B2 (en) | 1999-06-11 | 1999-06-11 | Formulations comprising lipid-regulating agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/330,588 US6368620B2 (en) | 1999-06-11 | 1999-06-11 | Formulations comprising lipid-regulating agents |
Publications (2)
Publication Number | Publication Date |
---|---|
US20010007669A1 true US20010007669A1 (en) | 2001-07-12 |
US6368620B2 US6368620B2 (en) | 2002-04-09 |
Family
ID=23290425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/330,588 Expired - Lifetime US6368620B2 (en) | 1999-06-11 | 1999-06-11 | Formulations comprising lipid-regulating agents |
Country Status (1)
Country | Link |
---|---|
US (1) | US6368620B2 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1354581A1 (en) * | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Porous substance and process for producing the same |
US20040241235A1 (en) * | 2001-03-09 | 2004-12-02 | Christophe Lebon | Granules and granules coated with a masked taste |
WO2008002568A2 (en) * | 2006-06-26 | 2008-01-03 | Mutual Pharmaceutical Company, Inc. | Active agent formulations, methods of making, and methods of use |
US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
US20090004282A1 (en) * | 2005-07-15 | 2009-01-01 | Linda Sze Tu | Method of Particle Formation |
US20090074872A1 (en) * | 2006-06-26 | 2009-03-19 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
JP2010013462A (en) * | 2002-05-24 | 2010-01-21 | Elan Pharma Internatl Ltd | Nanoparticulate fibrate formulation |
US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
US20100183725A1 (en) * | 2005-07-15 | 2010-07-22 | Map Pharmaceuticals, Inc. | Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof |
US20100291221A1 (en) * | 2009-05-15 | 2010-11-18 | Robert Owen Cook | Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000018374A1 (en) * | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
US8236352B2 (en) * | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US20040115134A1 (en) * | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
US20090104273A1 (en) * | 1999-06-22 | 2009-04-23 | Elan Pharma International Ltd. | Novel nifedipine compositions |
US7863331B2 (en) * | 1999-07-09 | 2011-01-04 | Ethypharm | Pharmaceutical composition containing fenofibrate and method for the preparation thereof |
FR2795961B1 (en) * | 1999-07-09 | 2004-05-28 | Ethypharm Lab Prod Ethiques | PHARMACEUTICAL COMPOSITION CONTAINING MICRONIZED FENOFIBRATE, A SURFACTANT AND A BINDING CELLULOSIC DERIVATIVE AND PREPARATION METHOD |
US20040156872A1 (en) * | 2000-05-18 | 2004-08-12 | Elan Pharma International Ltd. | Novel nimesulide compositions |
US7198795B2 (en) * | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
US20040126900A1 (en) * | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
AU2002322024B2 (en) * | 2001-05-31 | 2008-05-08 | Pacira Pharmaceuticals, Inc. | Encapsulation of nanosuspensions in liposomes and microspheres |
WO2003013607A1 (en) * | 2001-08-07 | 2003-02-20 | Galephar M/F | ORAL PHARMACEUTICAL COMPOSITION CONTAINING A COMBINATION OF FENOFIBRATE AND A HMG-CoA REDUCTASE INHIBITOR |
CA2475092C (en) * | 2002-02-04 | 2012-05-01 | Christian F. Wertz | Nanoparticulate compositions having lysozyme as a surface stabilizer |
US20040101566A1 (en) * | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
CA2479665C (en) * | 2002-03-20 | 2011-08-30 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
NO346970B1 (en) * | 2002-05-24 | 2023-03-20 | Alkermes Pharma Ireland Ltd | Nanoparticulate fiber formulations |
US20070264348A1 (en) * | 2002-05-24 | 2007-11-15 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
ATE462418T1 (en) * | 2003-08-06 | 2010-04-15 | Galephar M F | STABLE PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED RELEASE OF FENOFIBRATE AND PRAVASTATIN |
KR100603974B1 (en) | 2003-12-05 | 2006-07-25 | 김갑식 | Method for preparing nano-scale or amorphous particle using solid fat as a solvent |
CA2600407A1 (en) * | 2005-03-30 | 2006-10-12 | Teva Pharmaceutical Industries Ltd. | Fibrate compositions containing a surfactant mixture of peg-600 and poloxamer 407 |
US20070148233A1 (en) * | 2005-12-28 | 2007-06-28 | Lerner E I | Pharmaceutical formulations of fenofibrate having improved bioavailability |
CN101134018B (en) * | 2006-07-18 | 2011-09-07 | 安徽省现代中药研究中心 | Fenofibrate pellet and method for preparing the same |
US20080161594A1 (en) * | 2006-12-29 | 2008-07-03 | Industrial Technology Research Institute | Method for fabricating nanoparticles containing fenofibrate |
CA2793241C (en) | 2010-03-22 | 2020-07-14 | Bio-Synectics Inc. | Method for preparing nano-particles |
WO2014091318A1 (en) | 2012-12-11 | 2014-06-19 | Lupin Atlantis Holdings, S.A. | Reduced dose pharmaceutical compositions of fenofibrate |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545423A (en) * | 1991-11-25 | 1996-08-13 | Vivorx, Inc. | Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials |
US5776486A (en) * | 1993-05-28 | 1998-07-07 | Aphios Corporation | Methods and apparatus for making liposomes containing hydrophobic drugs |
US5545628A (en) * | 1995-01-10 | 1996-08-13 | Galephar P.R. Inc. | Pharmaceutical composition containing fenofibrate |
US5766637A (en) * | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
FR2758459B1 (en) | 1997-01-17 | 1999-05-07 | Pharma Pass | FENOFIBRATE PHARMACEUTICAL COMPOSITION HAVING HIGH BIODAVAILABILITY AND PROCESS FOR PREPARING THE SAME |
-
1999
- 1999-06-11 US US09/330,588 patent/US6368620B2/en not_active Expired - Lifetime
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
US20040052854A1 (en) * | 2000-12-26 | 2004-03-18 | Tomohiro Yoshinari | Porous substances and methods for producing the same |
US20050232954A1 (en) * | 2000-12-26 | 2005-10-20 | Tomohiro Yoshinari | Porous substances and methods for producing the same |
EP1354581A4 (en) * | 2000-12-26 | 2007-07-04 | Takeda Pharmaceutical | Porous substance and process for producing the same |
EP1354581A1 (en) * | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Porous substance and process for producing the same |
US20040241235A1 (en) * | 2001-03-09 | 2004-12-02 | Christophe Lebon | Granules and granules coated with a masked taste |
US20110212182A1 (en) * | 2001-03-09 | 2011-09-01 | Ethypharm | Masked taste pharmaceutical granules/granulates |
JP2010013462A (en) * | 2002-05-24 | 2010-01-21 | Elan Pharma Internatl Ltd | Nanoparticulate fibrate formulation |
US20090004282A1 (en) * | 2005-07-15 | 2009-01-01 | Linda Sze Tu | Method of Particle Formation |
US20100183725A1 (en) * | 2005-07-15 | 2010-07-22 | Map Pharmaceuticals, Inc. | Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof |
US8475845B2 (en) | 2005-07-15 | 2013-07-02 | Map Pharmaceuticals, Inc. | Method of particle formation |
US20080220076A1 (en) * | 2006-06-26 | 2008-09-11 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
WO2008002568A3 (en) * | 2006-06-26 | 2008-04-17 | Mutual Pharmaceutical Co | Active agent formulations, methods of making, and methods of use |
US20090074872A1 (en) * | 2006-06-26 | 2009-03-19 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
US20080050450A1 (en) * | 2006-06-26 | 2008-02-28 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
WO2008002568A2 (en) * | 2006-06-26 | 2008-01-03 | Mutual Pharmaceutical Company, Inc. | Active agent formulations, methods of making, and methods of use |
US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
US20100291221A1 (en) * | 2009-05-15 | 2010-11-18 | Robert Owen Cook | Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation |
Also Published As
Publication number | Publication date |
---|---|
US6368620B2 (en) | 2002-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6368620B2 (en) | Formulations comprising lipid-regulating agents | |
US8206746B2 (en) | Microparticles of water-insoluble substances | |
JP4334869B2 (en) | Compositions with improved solubility or oral absorption | |
DE60129573T2 (en) | PROCESS FOR SPRAY DRYING OF COMPOSITIONS CONTAINING FENOFIBRATE | |
EP2600846B1 (en) | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine | |
JP2007112816A (en) | Re-dispersible ultrafine particle-like film matrix having protective membrane | |
EP1414410B1 (en) | Nanoparticulate formulations of fenofibrate | |
MXPA01009840A (en) | Novel formulations comprising lipid-regulating agents. | |
US7255877B2 (en) | Fenofibrate microparticles | |
KR20030018083A (en) | Compositions containing itraconazole and their preparation methods | |
AU2021232924B2 (en) | Surfactants for healthcare products | |
JP2003501376A (en) | Oil core compositions for sustained release of hydrophobic drugs | |
JP2005509596A6 (en) | Fenofibrate nanoparticle formulation | |
TW201143770A (en) | Stabilized tacrolimus composition | |
JP2002540174A (en) | Novel formulation containing lipid regulator | |
CA2355820A1 (en) | Novel formulations comprising lipid-regulating agents | |
US6838091B2 (en) | Formulations comprising lipid-regulating agents | |
KR20150102083A (en) | Injectable depot formulation comprising optically active tolvaptan and process of producing the same | |
WO2019219823A1 (en) | Solid dispersion containing ritonavir | |
US6814977B1 (en) | Formulations comprising lipid-regulating agents | |
JP4536373B2 (en) | New composition | |
EP1249231A1 (en) | Pharmaceutical formulations comprising anti-inflammatory compounds and use thereof | |
KR101859200B1 (en) | Pharmaceutical composition of monoacetyldiacylglycerol compound for oral administration and solid pharmaceutical preparation | |
US8535716B2 (en) | Methods and composition of extended delivery of water insoluble drugs | |
US20020040046A1 (en) | Novel formulations comprising lipid-regulating agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ABBOTT LABORATORIES, ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LIU, RONG (RON);PAN, QINGHAI;LEE, DENNIS;REEL/FRAME:010227/0174;SIGNING DATES FROM 19990816 TO 19990820 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
AS | Assignment |
Owner name: ABBVIE INC., ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ABBOTT LABORATORIES;REEL/FRAME:030167/0463 Effective date: 20120801 |
|
FPAY | Fee payment |
Year of fee payment: 12 |