US1983944A

US1983944A - Production of antiricketic

Info

Publication number: US1983944A
Authority: US
Publication date: 1934-12-11
Anticipated expiration: 1951-12-11

Description

UNITED STATES PRODUCTION OF ANTIRICKETIC SUBSTANCES August J. Pacini, Chicago, Ill., assignor to Ameri-.

can Research Delaware Products, Inc., a corporation of No Drawing. Application August 13, 1928, Serial No. 299,453

Claims.

5 sistance, promotion or catalysis of the synthesis and transmutation of anti-ricketic and similar substances; and to the production of anti-ricketic products by use of cathode and canal rays.

The invention is a continuation in part of my patent applications, Serial Numbers 215,264 and 239,258, filed August 24, 1927 and December 10, 1927, respectively, now Patents Nos. 1,681,120 and 1,771,343 respectively.

A general object of the invention is the pro-- vision of a new process of producing the antiricketic vitamin D comprising the treatment of an activatible substance by corpuscular discharges as for instance canal rays, cathode rays such as emanate from a Lenard tube, or emanations of naturally radioactive substances.

Among the several more specific objects of the invention may be noted the treatment of substances which elaborate growth-producing substances, to produce anti-ricketic substances which include the so-called vitamin D, by the use of?" radiation characterized as not being ordinarily included in the electromagnetic spectrum, such as cathode and canal rays or other rays of the corpuscular discharge type.

Another object of the invention is to provide means of the class described, by which commercial production of anti-ricketic food and medicinal products may be practically accomplished on a substantial scale of operations.

Another object of the invention is the provision of improved means for converting substances into anti-ricketic substances which include the so-called vitamin D, without necessarily including biologically effective ultraviolet radiation, but including cathode or canal ray radiation, together with a promoting or catalyzing means.

Another object of the invention is to provide catalysts as converting or synthesizing means of the class described, by which commercial production of anti-ricketic food and medicinal products may be more practically accomplished on a substantial scale of operations.

, Other objects will be in part obvious and in part pointed out hereinafter.

The invention accordingly comprises the elements and combinations of elements, steps and sequence of steps, features of construction and arrangements which will be exemplified in the articles hereinafter described, and the scope of the application of which will be indicated in the following claims.

The above mentioned radiations may be used to produce anti-ricketic properties in any activatible substance such as cholesterol, for example, and in the common food substances olive oil, oleomargarine and rolled oats.

As an illustration of an application of the invention, any activatible substance, as for example cholesterol, is briefly exposed to cathode rays obtained from a modified Lenard tube such as is used for classical physics experiments, or any equivalent thereof in which a high tension current passes from one electrode to the other and the canal rays are then allowed to pass through any adequate metallic window in the tube. In consequence of this practically momentary exposure, vitamin D properties are developed.

In place of using the cathode rays, canal rays may be substituted to effect the desired activation.

Moreover, it is possible to secondarily induce cathode rays by bombardment of a resistant material with X-rays and utilize such rays for purposes of activation, in place of rays produced in a Lenard tube.

Again, the corpuscular emanations of naturally radioactive substances such as thorium, radium, uranium and similar materials can be used to effect the production of vitamin D from activatible substances.

The exposure is terminated before the substance becomes rancidified.

In consequence of such treatment the cholesterol, suffers modifications in due time revealed by the following changes; a lowering in the melting point, a tendency to change color passing from pure white to cream-yellow or deeper, a change in solubility in organic solvents, no apparent change in empiric constitution, a change in its reaction towards certain reagents (such as freshly distilled aniline 15 parts mixed with 1 part of pure hydrochloric acid, with which reagent unaltered cholesterol gives no color on boiling, but activated cholesterol produces a burgundy red color indicative of a change), and finally, that the cholesterol, previously incapable of serving as an anti-ricketic becomes powerfully anti-ricketic, depending upon the factors of exposure.

The action of the rays can be interpreted in terms of photo-chemistry and probably involves electronic re-orientation in the atoms of the molecules undergoing activation.

It is another primary one of the objects of this invention to provide means whereby cathode and catalysts to be used vary with the reactions and raw materials used, their choice being governed by experiment.

The catalyst may be placedwith the material and left there after activation, or removed, at

" ,the will of the operator.

t A catalyst as herein used is defined as any substance which, with regard to vitamins, will accelerate reactions between activatible material and radiation sources of the class hereinbefore set out.

Having described the details of the method for making the above conversions-and transmutations, the following is to be made clear.

Foods are rendered anti-ricketic, either by applying the growth-producing substances or other activatible substances to the food by wet or dry mixing'and then exposing the thus treated food to cathode or canal rays, either aloneor through the use of catalysts. r the'activatible substances may be first rendered anti-ricketic and then applied to the foods by wet or dry mixing, or the food may be exposed directly without previous admixture of any sort, as in the case of seed oils, cereals, and the like. Mixing may be accomplished mechanically or otherwise.

The same variations of method hold with respect to the manufacture of medicinal products, although the direct methods, hereinbefore described, are preferable in the case of the manufacture of said medicinal products.

In view of the foregoing, it will be seen that the several objects of the invention are achieved and other advantageous results attained.

As many changes could be made in carrying out the above objects without departing from the scope of the invention, it is. intended that all matter contained in the above description shall beinterpreted as illustrative and not in;

comprising a member of the group chlorine and bromine, said exposure being terminated before the substance becomes rancidified.

2. The method of treating a substance containing appropriate activating material to become anti-ricketic comprising exposing the substance to rays of the corpuscular discharge type in the presence of a catalyst comprising a member of the group chlorine and'bromine for accelerating the effects of said rays.

3. The method of treating cholesterol to cause it to become anti-ricketic comprising exposing the same to rays of the corpuscular discharge type, and accelerating the efiect'of the exposure by carrying it on in the presence of a catalyst comprising a member of the group chlorine and bromine, said exposure being of the order of one minute's duration.

4. The process of treating alimentary products which consists in subjecting the same to low velocity cathode rays and of the order of 7 those emanating from a Lenard tube for a sufficient length of time only to develop vitamin D therein.

*5. The process of treating alimentary products which consists in subjecting the same to a low velocity corpuscular discharge such as emanates from a Lenard tube, for a suificient length of time only to develop vitamin D therein;

AUGUST J. PACINI.