US1983944A - Production of antiricketic - Google Patents
Production of antiricketic Download PDFInfo
- Publication number
- US1983944A US1983944A US1983944DA US1983944A US 1983944 A US1983944 A US 1983944A US 1983944D A US1983944D A US 1983944DA US 1983944 A US1983944 A US 1983944A
- Authority
- US
- United States
- Prior art keywords
- rays
- substances
- ricketic
- cathode
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002050 anti-rickettsial Effects 0.000 title description 32
- 238000004519 manufacturing process Methods 0.000 title description 16
- 239000000126 substance Substances 0.000 description 40
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 24
- 235000013305 food Nutrition 0.000 description 16
- 229940046008 Vitamin D Drugs 0.000 description 14
- 229930003316 Vitamin D Natural products 0.000 description 14
- 239000003054 catalyst Substances 0.000 description 14
- 235000019166 vitamin D Nutrition 0.000 description 14
- 239000011710 vitamin D Substances 0.000 description 14
- 150000003710 vitamin D derivatives Chemical class 0.000 description 14
- 229940107161 Cholesterol Drugs 0.000 description 12
- 235000012000 cholesterol Nutrition 0.000 description 12
- 239000000463 material Substances 0.000 description 10
- 230000004913 activation Effects 0.000 description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 229910052801 chlorine Inorganic materials 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000007580 dry-mixing Methods 0.000 description 4
- 239000000941 radioactive substance Substances 0.000 description 4
- 230000002194 synthesizing Effects 0.000 description 4
- 244000075850 Avena orientalis Species 0.000 description 2
- 235000007319 Avena orientalis Nutrition 0.000 description 2
- 229910052776 Thorium Inorganic materials 0.000 description 2
- 229910052770 Uranium Inorganic materials 0.000 description 2
- 229940029983 VITAMINS Drugs 0.000 description 2
- 229940021016 Vitamin IV solution additives Drugs 0.000 description 2
- 230000003213 activating Effects 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atoms Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 150000001841 cholesterols Chemical class 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006011 modification reaction Methods 0.000 description 2
- 238000009377 nuclear transmutation Methods 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000001737 promoting Effects 0.000 description 2
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 description 2
- 229910052705 radium Inorganic materials 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- ZSLUVFAKFWKJRC-UHFFFAOYSA-N thorium Chemical compound [Th] ZSLUVFAKFWKJRC-UHFFFAOYSA-N 0.000 description 2
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamins Natural products 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
Definitions
- a general object of the invention is the pro-- vision of a new process of producing the antiricketic vitamin D comprising the treatment of an activatible substance by corpuscular discharges as for instance canal rays, cathode rays such as emanate from a Lenard tube, or emanations of naturally radioactive substances.
- Another object of the invention is to provide means of the class described, by which commercial production of anti-ricketic food and medicinal products may be practically accomplished on a substantial scale of operations.
- Another object of the invention is the provision of improved means for converting substances into anti-ricketic substances which include the so-called vitamin D, without necessarily including biologically effective ultraviolet radiation, but including cathode or canal ray radiation, together with a promoting or catalyzing means.
- Another object of the invention is to provide catalysts as converting or synthesizing means of the class described, by which commercial production of anti-ricketic food and medicinal products may be more practically accomplished on a substantial scale of operations.
- the above mentioned radiations may be used to produce anti-ricketic properties in any activatible substance such as cholesterol, for example, and in the common food substances olive oil, oleomargarine and rolled oats.
- any activatible substance as for example cholesterol
- a modified Lenard tube such as is used for classical physics experiments, or any equivalent thereof in which a high tension current passes from one electrode to the other and the canal rays are then allowed to pass through any adequate metallic window in the tube.
- vitamin D properties are developed.
- canal rays may be substituted to effect the desired activation.
- the corpuscular emanations of naturally radioactive substances such as thorium, radium, uranium and similar materials can be used to effect the production of vitamin D from activatible substances.
- the exposure is terminated before the substance becomes rancidified.
- the cholesterol suffers modifications in due time revealed by the following changes; a lowering in the melting point, a tendency to change color passing from pure white to cream-yellow or deeper, a change in solubility in organic solvents, no apparent change in empiric constitution, a change in its reaction towards certain reagents (such as freshly distilled aniline 15 parts mixed with 1 part of pure hydrochloric acid, with which reagent unaltered cholesterol gives no color on boiling, but activated cholesterol produces a burgundy red color indicative of a change), and finally, that the cholesterol, previously incapable of serving as an anti-ricketic becomes powerfully anti-ricketic, depending upon the factors of exposure.
- certain reagents such as freshly distilled aniline 15 parts mixed with 1 part of pure hydrochloric acid, with which reagent unaltered cholesterol gives no color on boiling, but activated cholesterol produces a burgundy red color indicative of a change
- the action of the rays can be interpreted in terms of photo-chemistry and probably involves electronic re-orientation in the atoms of the molecules undergoing activation.
- the catalyst may be placedwith the material and left there after activation, or removed, at
- t A catalyst as herein used is defined as any substance which, with regard to vitamins, will accelerate reactions between activatible material and radiation sources of the class hereinbefore set out.
- Foods are rendered anti-ricketic, either by applying the growth-producing substances or other activatible substances to the food by wet or dry mixing'and then exposing the thus treated food to cathode or canal rays, either aloneor through the use of catalysts.
- the'activatible substances may be first rendered anti-ricketic and then applied to the foods by wet or dry mixing, or the food may be exposed directly without previous admixture of any sort, as in the case of seed oils, cereals, and the like. Mixing may be accomplished mechanically or otherwise.
- the method of treating a substance containing appropriate activating material to become anti-ricketic comprising exposing the substance to rays of the corpuscular discharge type in the presence of a catalyst comprising a member of the group chlorine and'bromine for accelerating the effects of said rays.
- the method of treating cholesterol to cause it to become anti-ricketic comprising exposing the same to rays of the corpuscular discharge type, and accelerating the efiect'of the exposure by carrying it on in the presence of a catalyst comprising a member of the group chlorine and bromine, said exposure being of the order of one minute's duration.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
UNITED STATES PRODUCTION OF ANTIRICKETIC SUBSTANCES August J. Pacini, Chicago, Ill., assignor to Ameri-.
can Research Delaware Products, Inc., a corporation of No Drawing. Application August 13, 1928, Serial No. 299,453
Claims.
5 sistance, promotion or catalysis of the synthesis and transmutation of anti-ricketic and similar substances; and to the production of anti-ricketic products by use of cathode and canal rays.
The invention is a continuation in part of my patent applications, Serial Numbers 215,264 and 239,258, filed August 24, 1927 and December 10, 1927, respectively, now Patents Nos. 1,681,120 and 1,771,343 respectively.
A general object of the invention is the pro-- vision of a new process of producing the antiricketic vitamin D comprising the treatment of an activatible substance by corpuscular discharges as for instance canal rays, cathode rays such as emanate from a Lenard tube, or emanations of naturally radioactive substances.
Among the several more specific objects of the invention may be noted the treatment of substances which elaborate growth-producing substances, to produce anti-ricketic substances which include the so-called vitamin D, by the use of?" radiation characterized as not being ordinarily included in the electromagnetic spectrum, such as cathode and canal rays or other rays of the corpuscular discharge type.
Another object of the invention is to provide means of the class described, by which commercial production of anti-ricketic food and medicinal products may be practically accomplished on a substantial scale of operations.
Another object of the invention is the provision of improved means for converting substances into anti-ricketic substances which include the so-called vitamin D, without necessarily including biologically effective ultraviolet radiation, but including cathode or canal ray radiation, together with a promoting or catalyzing means.
Another object of the invention is to provide catalysts as converting or synthesizing means of the class described, by which commercial production of anti-ricketic food and medicinal products may be more practically accomplished on a substantial scale of operations.
, Other objects will be in part obvious and in part pointed out hereinafter.
The invention accordingly comprises the elements and combinations of elements, steps and sequence of steps, features of construction and arrangements which will be exemplified in the articles hereinafter described, and the scope of the application of which will be indicated in the following claims.
The above mentioned radiations may be used to produce anti-ricketic properties in any activatible substance such as cholesterol, for example, and in the common food substances olive oil, oleomargarine and rolled oats.
As an illustration of an application of the invention, any activatible substance, as for example cholesterol, is briefly exposed to cathode rays obtained from a modified Lenard tube such as is used for classical physics experiments, or any equivalent thereof in which a high tension current passes from one electrode to the other and the canal rays are then allowed to pass through any adequate metallic window in the tube. In consequence of this practically momentary exposure, vitamin D properties are developed.
In place of using the cathode rays, canal rays may be substituted to effect the desired activation.
Moreover, it is possible to secondarily induce cathode rays by bombardment of a resistant material with X-rays and utilize such rays for purposes of activation, in place of rays produced in a Lenard tube.
Again, the corpuscular emanations of naturally radioactive substances such as thorium, radium, uranium and similar materials can be used to effect the production of vitamin D from activatible substances.
The exposure is terminated before the substance becomes rancidified.
In consequence of such treatment the cholesterol, suffers modifications in due time revealed by the following changes; a lowering in the melting point, a tendency to change color passing from pure white to cream-yellow or deeper, a change in solubility in organic solvents, no apparent change in empiric constitution, a change in its reaction towards certain reagents (such as freshly distilled aniline 15 parts mixed with 1 part of pure hydrochloric acid, with which reagent unaltered cholesterol gives no color on boiling, but activated cholesterol produces a burgundy red color indicative of a change), and finally, that the cholesterol, previously incapable of serving as an anti-ricketic becomes powerfully anti-ricketic, depending upon the factors of exposure.
The action of the rays can be interpreted in terms of photo-chemistry and probably involves electronic re-orientation in the atoms of the molecules undergoing activation.
It is another primary one of the objects of this invention to provide means whereby cathode and catalysts to be used vary with the reactions and raw materials used, their choice being governed by experiment.
The catalyst may be placedwith the material and left there after activation, or removed, at
" ,the will of the operator.
t A catalyst as herein used is defined as any substance which, with regard to vitamins, will accelerate reactions between activatible material and radiation sources of the class hereinbefore set out.
Having described the details of the method for making the above conversions-and transmutations, the following is to be made clear.
Foods are rendered anti-ricketic, either by applying the growth-producing substances or other activatible substances to the food by wet or dry mixing'and then exposing the thus treated food to cathode or canal rays, either aloneor through the use of catalysts. r the'activatible substances may be first rendered anti-ricketic and then applied to the foods by wet or dry mixing, or the food may be exposed directly without previous admixture of any sort, as in the case of seed oils, cereals, and the like. Mixing may be accomplished mechanically or otherwise.
The same variations of method hold with respect to the manufacture of medicinal products, although the direct methods, hereinbefore described, are preferable in the case of the manufacture of said medicinal products.
In view of the foregoing, it will be seen that the several objects of the invention are achieved and other advantageous results attained.
As many changes could be made in carrying out the above objects without departing from the scope of the invention, it is. intended that all matter contained in the above description shall beinterpreted as illustrative and not in;
comprising a member of the group chlorine and bromine, said exposure being terminated before the substance becomes rancidified.
2. The method of treating a substance containing appropriate activating material to become anti-ricketic comprising exposing the substance to rays of the corpuscular discharge type in the presence of a catalyst comprising a member of the group chlorine and'bromine for accelerating the effects of said rays.
3. The method of treating cholesterol to cause it to become anti-ricketic comprising exposing the same to rays of the corpuscular discharge type, and accelerating the efiect'of the exposure by carrying it on in the presence of a catalyst comprising a member of the group chlorine and bromine, said exposure being of the order of one minute's duration.
4. The process of treating alimentary products which consists in subjecting the same to low velocity cathode rays and of the order of 7 those emanating from a Lenard tube for a sufficient length of time only to develop vitamin D therein.
*5. The process of treating alimentary products which consists in subjecting the same to a low velocity corpuscular discharge such as emanates from a Lenard tube, for a suificient length of time only to develop vitamin D therein;
AUGUST J. PACINI.
Publications (1)
Publication Number | Publication Date |
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US1983944A true US1983944A (en) | 1934-12-11 |
Family
ID=3426769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US1983944D Expired - Lifetime US1983944A (en) | Production of antiricketic |
Country Status (1)
Country | Link |
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US (1) | US1983944A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE845033C (en) * | 1949-02-16 | 1952-07-28 | Oskar Dipl-Chem Seeming | Process for enhancing the therapeutic effect of yeast preparations |
-
0
- US US1983944D patent/US1983944A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE845033C (en) * | 1949-02-16 | 1952-07-28 | Oskar Dipl-Chem Seeming | Process for enhancing the therapeutic effect of yeast preparations |
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