US168240A - Improvement in the manufacture of pills - Google Patents
Improvement in the manufacture of pills Download PDFInfo
- Publication number
- US168240A US168240A US168240DA US168240A US 168240 A US168240 A US 168240A US 168240D A US168240D A US 168240DA US 168240 A US168240 A US 168240A
- Authority
- US
- United States
- Prior art keywords
- pills
- mold
- pill
- manufacture
- improvement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006187 pill Substances 0.000 title description 36
- 238000004519 manufacturing process Methods 0.000 title description 10
- 229940023488 Pill Drugs 0.000 description 22
- 239000000463 material Substances 0.000 description 16
- 238000007906 compression Methods 0.000 description 14
- 239000002245 particle Substances 0.000 description 14
- 238000001035 drying Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 230000001050 lubricating Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001680 brushing Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- 239000012254 powdered material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/0053—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor combined with a final operation, e.g. shaping
- B29C45/006—Joining parts moulded in separate cavities
Landscapes
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Drying Of Solid Materials (AREA)
Description
UNITED STATES PATENT OFFIGE.
JACOB DUNTON, or PHILADELPHIA, PENNSYLVANIA.
IMPROVEMENT m THE MANUFACTURE OFYPILLS.
Specification forming part of Letters Patent No. 168,240, dated September 28, 1875 application filed September 4, 1875.
To all whom it may concern:
Be it known that I, JACOB DUNTON, of the city and county of Philadelphia and State of Pennsylvania, have invented a new and useful Improvement in the Manufacture of Pills; and I do hereby declare that the following is a full, clear, and exact description of the same.
This invention relates to certain improvements in the manufacture of pills made by compression in dies or molds. In manufacturing pills according to this method it is dfound that the pill compressed of materials containing the natural moisture of the air possesses but little cohesion of particles and stability of form, and in removing them from the. die the attraction of adhesion is often greater than that of cohesion, and they'crumble and break in such a manner as to render this method of compressing certain materials into pills wholly impracticable.
My invention is intended to obviate this difficulty; and it consists in the method of drying the material to be compressed so as to expel the moisture, and insure the more thorough cohesion of particles and the lubrication of the die or mold, as hereinafter more fully described.
In carrying out my invention the powdered materials are first dried, preferably at a temperature of 90 Fahrenheit, so as to deprive them of the natural moisture absorbed from the air, which would have a tendency to de compose them or interfere with the compressibility or stability of compression.
The materials are now in proper condition for compression and the cohesion of particles. In order to compress, however, such substances as sulphate of quinia, and other substances which leave a portion of themselves adhering to the mold after compression, which adherence prevents the formation and withdrawal of a successive pill of the same mate-' rial in a perfect or merchantable condition, it becomes necessary to get rid of the adherence, and also to prepare the mold before another pillcan be made. The ways which may be adopted are, first, after the pill is made, open the mold and brush out with a stiff brush as 7 much as possible of the adhering particles, and
then apply to the surface of the mold a thin film of oil, which takes or soaks up any portion of the particles which is left after brushing, and to 'get rid of the oil a pill of starch or other equivalent material is made, which absorbs the oil, and leaves the mold in a condition to make another pill of the original material second, instead of lubricating the mold directly, a small portion of a liquid may be added to the powder, (one per cent. being in some cases sufficient,) which under pressure will ooze out at the surface of the pill, and act as a lubricant, so as to allow the pill to be removed from the mold without leaving any particles adhering to the mold, and leaving the latter in fit condition for the next pill.
The liquids used may be alcohol, benzine, ether, chloroform, water, or other volatile liquids, that liquid being preferably selected in which the material is insoluble, or the least soluble, so as to have the least or no effect upon thematerials to be compressed. Any trace of the liquid used which may adhere to the pill may be expelled from the same by evaporation in a dry atmosphere.
rial, or a material which is of itself both unc-,
tuous and absorbent, for cleaning and lubricating the molds.
I am aware of the fact that it is not new to make pills by compression, and 1 do not claim such broadly, but confine my invention to the particular methodof preparing the powders by drying and preventing the adhesion to the mold, in which the drying not only makes the particles cohere better and remain more stable, but in compressing such substances as iodide of potassium, which absorbs moisture from a damp atmosphere, the salt, if; compressed in that condition, acts upon the iron, and forms a pink discoloration upon the surface of the pill that interferes with its purity and salability. This said reaction upon the iron dies is not confined to iodide of potassium alone, but occurs with numerous substances, but is in every case entirely obviated by the previous drying at about 90 Fahrenheit, with 24 of absolute dryness, (Masons hygrometer.)
Having thus described my invention, what I claim as new is-- In manufacturing pills by compression, the herein-described method of drying the powders, before compression, at a temperature of about 90 Fahrenheit, with 24 absolute dryness, '(Masons hygrometer,) to prevent reaction upon'the mold, and insure stability of cohesion, and lubricating the'mold to prevent adhesion, and insure the removal of the pill integrally and perfect.
JACOB DUNTON. Witnesses:
LORENZO WESTGOTT, CASPER S. GARMELL.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US168240A true US168240A (en) | 1875-09-28 |
Family
ID=2237649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US168240D Expired - Lifetime US168240A (en) | Improvement in the manufacture of pills |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US168240A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9205089B2 (en) | 2011-04-29 | 2015-12-08 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
| US10213960B2 (en) | 2014-05-20 | 2019-02-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
| US20200297689A1 (en) * | 2009-07-21 | 2020-09-24 | Keryx Biopharmaceuticals, Inc. | Ferric citrate dosage forms |
-
0
- US US168240D patent/US168240A/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200297689A1 (en) * | 2009-07-21 | 2020-09-24 | Keryx Biopharmaceuticals, Inc. | Ferric citrate dosage forms |
| US9205089B2 (en) | 2011-04-29 | 2015-12-08 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
| US10213960B2 (en) | 2014-05-20 | 2019-02-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
| US10703048B2 (en) | 2014-05-20 | 2020-07-07 | Massachusetts Institute Of Technology | Plasticity induced bonding |
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