US1570328A - Method for sterile preservation of dosed medicaments and of their solvents - Google Patents
Method for sterile preservation of dosed medicaments and of their solvents Download PDFInfo
- Publication number
- US1570328A US1570328A US5670A US567025A US1570328A US 1570328 A US1570328 A US 1570328A US 5670 A US5670 A US 5670A US 567025 A US567025 A US 567025A US 1570328 A US1570328 A US 1570328A
- Authority
- US
- United States
- Prior art keywords
- medicament
- ampulla
- liquid
- dosed
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title description 65
- 238000000034 method Methods 0.000 title description 10
- 238000004321 preservation Methods 0.000 title description 4
- 239000002904 solvent Substances 0.000 title description 3
- 239000003708 ampul Substances 0.000 description 34
- 239000007788 liquid Substances 0.000 description 29
- 239000000969 carrier Substances 0.000 description 20
- 239000000243 solution Substances 0.000 description 6
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- 238000003303 reheating Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3277—Ampoules
Definitions
- Ampullae have become known which serve for the separate storing of medicaments designed for injection and in whJ'ch the solid substance has to be dissolved in the dissolving liquid shortly before it is used, the dissolving being done in thecompartment of the ampulla which contains the liquid. It is not. necessary to remove the liquid from the ampulla as the separately stored medicament which mostly is a solid one is brought into theliquid containing ampulla. With this object in view the medicament in one of the compartments of the ampulla has to be inspissated in the ampulla. In order to admixothe inspissated medicament with'the dissolving liquid it is necessary'to break the bottom of the ampulla and the fragments. with the medicament adhering to the same must drop into the liquid.
- Vvhen the dissolving liquid is filled in and sterilized after the medicament has been inspissated the medicament will suffer from the reheating and inversely when the medicament is inspissated after the liquid has been filled in the liquid will be unfavorably influenced.
- the inspissating of the medicament is carried 7 out in or on a separate medicament carrier, which remains independent of the ampulla.
- the Advantage is thus obtained that the total quantity of medicament gets into the dissolving liquid, that no splintering of glass is necessary and that the inspissating need not be effected in the double ampulla. It is furtheryadvantageous that in one ampulla several of these medicament carriers can be arranged so that it is possible either to vary the dosing or to preserve in one ampulla Various kinds of medicaments to be used according to requirement.
- the improved method is, illustrated on the accompanying drawing in which several forms of ampullze and of medicament carriers are shown which may be used for carrying out the improved process.
- FIG. 1 a medicament carrier of approximately natural size is shown inside Fig. 4 shows the ampulla with the medicament carrier at the moment when the medicament carrier is droppedinto the open liquid-containing ampulla. V
- Figs. 5,6 and? show three other forms of construction of medicament carriers.
- Fig. 8 shows one ampulla containing severalmedicament carriers.
- 3 A great-number of the medicament carriers, having the shape of a small boat a, of which one is shown in Figs. 1 and 2, are placed upon a heating plateand the dissolved accurately dosed medicament is brought with the aid of a convenient instrument into the carriera. The manipulation is carried out in formaline vapours. so that thesterile property of the medicament is not in danger. The inspissating requires only a few instants.
- Each carrier a is then inserted into glass ampulla b which is closed by melting.
- the medicament carrier (1 is thus loosely mounted in the ampulla a as shown in Fig.
- the medicament carrier can be dropped into the liquid. WVith this object in view the point of the ampulla b which contains the medicament carrier is broken off and the liquid carrier is transferred from the ampulla 6 into the open ampulla 0 without being touched with the hand, as shown in Fig. 4.
- the liquid carrier sinks to the bottom of the ampulla c and by slightly shaking this ampulla the medicament is dissolved by the liquid.
- the injection liquid thus formed is accurately dosed according to the prescription; it can be easily taken from the ampulla 0.
- a shown in Figs. 1, 2 and 3 medicament carriers (Z of semi-spherical shape as shown in Fig. 5 in plan view and in Fig. 6 in side elevation may be used, or rod-shaped medicament carriers 6, as shown in Fig. 7.
- the cup-shaped .medicamentcarriers 61 shown in Figs. 5 and 6 are filled with medicaments in a similar manneras described with regard to the boat-shaped medicament carrier.
- the plunging method is applied so that the sterility is being prcserved.
- the rod 0 is plunged into the liquid medicament up to half its length or for a part of its length and the medicament adhering to the rod is then allowed to dry.
- the medicament carrier may however be of any other convenient shape.
- the medicament car *iers of the shapes shown in Figs. 5, 6 and 7 or the medicament carriers of any other shape are also enclosed in an ampulla to be dropped shortly before use into the liquid ampulla in a similar manner as shown in Fig. 4:.
- Two or more medicament carriers a may be'stored in one ampulla as shown for instance in Fig. 8. With the commonly used medicament carriers the physician was bound to one predetermined dosing and a weaker dosing could not be prepared. If however several medicament carriers are enclosed in one ampulla the solution can be easily dosed according to requirement shortly before it is injected.
- Fig. 8 shows an ampulla in which four separate medicament carriers are enclosed. To prepare a strong dosed solution all four medicament carriers a a a, a are dropped into the dissolving liquid. If a patient is however less robust only three or two medicament carriers. and for children only one medicament carrier are dropped into the dissolving liquid. In this case an accurate dosing of the medicament according to the prevailing circumstances is easily carried out.
- the subdivision of the quantity of medicaments to be used presents further the advantage that different medicaments can be stored in one ampulla if an injection solution has to be prepared containing a mixture of different medicaments.
- medicaments may be stored in predetermined quantities and sterilized together with the corresponding quantity of accu- "ately dosed dissolving liquid until they are to be used, which for instance could .be desirable for bacteriologic agars.
- a method for the separate sterile preserving of dosed medicaments and dosed liquids consisting in inspissating quantities of different medicaments in separating medicament carriers of convenient shape, in storing these medicament carriers in one ampulla and in transferring all these medicament carriers into a dissolving liquid shortly before the solution has to be used.
Description
Jan. 19 1926. 1,570,328
E. BAUMGART METHOD FOR STERILE PRESERVATION OF DOSED MEDIGAMENTS AND OF THEIR SOLVIM'S Filed Jan. 29, 1925 Patented Jan. 19, 1926.
UNITED STATES I v 1,570,328 PATENT OFFICE.
EMIL BAU'MGART, FALKENBEZRG, GERMANY.
' METHOD FOR STERILE PRESERVATION OF DOSED ME DICAMENTS AND OF THEIR SOLVENTSy I i j Application filed January 29, 1925. Serial No. 5,670.
To all whom it may concern: I
Be it known that I, EMIL BAUMGART, a
citizen of the German Republic, residing at Methods for Sterile Preservation of Dosed Medicaments and of Their Solvents, of which the following is a specification.
Ampullae have become known which serve for the separate storing of medicaments designed for injection and in whJ'ch the solid substance has to be dissolved in the dissolving liquid shortly before it is used, the dissolving being done in thecompartment of the ampulla which contains the liquid. It is not. necessary to remove the liquid from the ampulla as the separately stored medicament which mostly is a solid one is brought into theliquid containing ampulla. With this object in view the medicament in one of the compartments of the ampulla has to be inspissated in the ampulla. In order to admixothe inspissated medicament with'the dissolving liquid it is necessary'to break the bottom of the ampulla and the fragments. with the medicament adhering to the same must drop into the liquid. It is a grave inconvenience if inj t-he injection liquid glass splinters are contained and it is further difficult to bring the total quantity of the medicament into the liquid containing ampulla as the particles of the medicament adhere often not only to the bottom but also to the side walls of the compartment of the ampulla. It may therefore happen easily that the in jection liquid is not correctly dosed and that the percentage of the medicament contained in this injection liquid is not sufficient. The sterilizing of the medicament in a two-compartments ampulla is sometimes prejudicial either for the medicament or for the dissolving liquid. Vvhen the dissolving liquid is filled in and sterilized after the medicament has been inspissated the medicament will suffer from the reheating and inversely when the medicament is inspissated after the liquid has been filled in the liquid will be unfavorably influenced.
In order to avoid these inconveniences the inspissating of the medicament is carried 7 out in or on a separate medicament carrier, which remains independent of the ampulla. The Advantage is thus obtained that the total quantity of medicament gets into the dissolving liquid, that no splintering of glass is necessary and that the inspissating need not be effected in the double ampulla. It is furtheryadvantageous that in one ampulla several of these medicament carriers can be arranged so that it is possible either to vary the dosing or to preserve in one ampulla Various kinds of medicaments to be used according to requirement.
The improved method is, illustrated on the accompanying drawing in which several forms of ampullze and of medicament carriers are shown which may be used for carrying out the improved process.
In'Fig. I a medicament carrier of approximately natural size is shown inside Fig. 4 shows the ampulla with the medicament carrier at the moment when the medicament carrier is droppedinto the open liquid-containing ampulla. V
. Figs. 5,6 and? show three other forms of construction of medicament carriers.
Fig. 8: shows one ampulla containing severalmedicament carriers. 3 A great-number of the medicament carriers, having the shape of a small boat a, of which one is shown in Figs. 1 and 2, are placed upon a heating plateand the dissolved accurately dosed medicament is brought with the aid of a convenient instrument into the carriera. The manipulation is carried out in formaline vapours. so that thesterile property of the medicament is not in danger. The inspissating requires only a few instants. Each carrier a is then inserted into glass ampulla b which is closed by melting. The medicament carrier (1 is thus loosely mounted in the ampulla a as shown in Fig. 3 and, after the neck of the ampulla c, which contains the liquid, has been broken off, the medicament carrier can be dropped into the liquid. WVith this object in view the point of the ampulla b which contains the medicament carrier is broken off and the liquid carrier is transferred from the ampulla 6 into the open ampulla 0 without being touched with the hand, as shown in Fig. 4. The liquid carrier sinks to the bottom of the ampulla c and by slightly shaking this ampulla the medicament is dissolved by the liquid. The injection liquid thus formed is accurately dosed according to the prescription; it can be easily taken from the ampulla 0.
Instead of the boat-shaped medicament carrier a shown in Figs. 1, 2 and 3 medicament carriers (Z of semi-spherical shape as shown in Fig. 5 in plan view and in Fig. 6 in side elevation may be used, or rod-shaped medicament carriers 6, as shown in Fig. 7. The cup-shaped .medicamentcarriers 61 shown in Figs. 5 and 6 are filled with medicaments in a similar manneras described with regard to the boat-shaped medicament carrier. For rod-shaped .or spherical medicament carriers the plunging method is applied so that the sterility is being prcserved. The rod 0 is plunged into the liquid medicament up to half its length or for a part of its length and the medicament adhering to the rod is then allowed to dry. The medicament carrier may however be of any other convenient shape. The medicament car *iers of the shapes shown in Figs. 5, 6 and 7 or the medicament carriers of any other shape are also enclosed in an ampulla to be dropped shortly before use into the liquid ampulla in a similar manner as shown in Fig. 4:. Two or more medicament carriers a may be'stored in one ampulla as shown for instance in Fig. 8. With the commonly used medicament carriers the physician was bound to one predetermined dosing and a weaker dosing could not be prepared. If however several medicament carriers are enclosed in one ampulla the solution can be easily dosed according to requirement shortly before it is injected.
Fig. 8 shows an ampulla in which four separate medicament carriers are enclosed. To prepare a strong dosed solution all four medicament carriers a a a, a are dropped into the dissolving liquid. If a patient is however less robust only three or two medicament carriers. and for children only one medicament carrier are dropped into the dissolving liquid. In this case an accurate dosing of the medicament according to the prevailing circumstances is easily carried out.
The subdivision of the quantity of medicaments to be used presents further the advantage that different medicaments can be stored in one ampulla if an injection solution has to be prepared containing a mixture of different medicaments.
In a similar manner other substances but medicaments may be stored in predetermined quantities and sterilized together with the corresponding quantity of accu- "ately dosed dissolving liquid until they are to be used, which for instance could .be desirable for bacteriologic agars.
I claim:
1. A. method for the separate sterile preserving of dosed medicaments and closed liquids in amullee or similar receptacles for the production of sterile solutions or sterile mixtures to be injected into the human or animal body or for other purposes, consisting in carrying out the inspissation of the medicament in special receptacles of convenient shape, and in storing there receptacles in a sealed ampulla from which they can be readily removed.
2. A. method for the separate sterile preserving of dosed medicaments and dosed liquids, consisting in inspissating a predetermined quantity of medicament designed for one solution in several carriers of convenient shape, in storing these medicament carriers in one ampulla when according to the strength of the solution required, some or all may be transferred to the solvent.
3. A method for the separate sterile preserving of dosed medicaments and dosed liquids, consisting in inspissating quantities of different medicaments in separating medicament carriers of convenient shape, in storing these medicament carriers in one ampulla and in transferring all these medicament carriers into a dissolving liquid shortly before the solution has to be used.
In testimony whereof I afiiX my signature.
EMIL BAUMGART.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5670A US1570328A (en) | 1925-01-29 | 1925-01-29 | Method for sterile preservation of dosed medicaments and of their solvents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5670A US1570328A (en) | 1925-01-29 | 1925-01-29 | Method for sterile preservation of dosed medicaments and of their solvents |
Publications (1)
Publication Number | Publication Date |
---|---|
US1570328A true US1570328A (en) | 1926-01-19 |
Family
ID=21717089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US5670A Expired - Lifetime US1570328A (en) | 1925-01-29 | 1925-01-29 | Method for sterile preservation of dosed medicaments and of their solvents |
Country Status (1)
Country | Link |
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US (1) | US1570328A (en) |
-
1925
- 1925-01-29 US US5670A patent/US1570328A/en not_active Expired - Lifetime
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