US1500985A

US1500985A - Method for producing antitoxins

Info

Publication number: US1500985A
Application number: US656134A
Authority: US
Inventors: Deutschmann Richard; Kotzenberg Wilhelm
Original assignee: Individual
Current assignee: Individual
Priority date: 1923-08-06
Filing date: 1923-08-06
Publication date: 1924-07-08
Anticipated expiration: 1941-07-08

Description

Patented July 8, 1924.

' UNITED STATES 1,500,985 PATENT OFFICE.

RICHARD DEUTSCHMANN AND WILHELM KOTZENBEBG, OF HAMBURG, MITHOD FOR PRODUCING ANTI'IOXINS.

Hp Drawing.

To all whom it ma concern:

Be it known t at we, Professor Dr. RICHARD DEUTSCHMANN, a citizen of Germany, and residin at Hamburg, Alsterkamp 19, and rofessor Dr. WILHELM Korzmmnne, a citizen of Germany, and residing at Hamburg, Magdalenenstrasse 6, Germany, have invented new and useful Methods for Producing Antitoxins (for which a patent application has been filed 1n the following is a specification.

The present invention refers to a method for producing antitoxins particularly for treating cancer and the like.

In carrying out the invention animals are treated with germ cell substances. The methods known heretofore for producing antitoxic sera generally culminated therein thatthe animals were inoculated with living or dead cultures of bacterii or with the poisons of such pathogenes against which the serum to be gained serves as an antitoxin. When it could be assumed that the animals had athered in their blood a sufiicient amount 0% counter-poison, blood was taken from them, and from it the serum, that is efi'ective against the disease in question, was produced.

Contrary to these known methods the new method is characterized therein that the animals are not infected by pathogenes or products from such, but germ cell substance, either such from ovarium or from the testicles or from both mixed to a prescribed proportion is introduced hypodermically or inoculated parenterally, that is to say anywhere exterior to the normal digestive canals. The nature of the animal fights against such foreign substances forced into it by forming antidotes, which after a certain time accumulate in the blood to such a concentration that the serum gained therefrom is rendered curative against abnormal excrescences or malignant tumor of the cells for instance cancer in the human organism.

By way of example the method can be carried out as follows:

A suitable animal, for instance a horse, will be inoculated by a mixture of ovariumand testicle-juice in a certain of mixture to be regulated accor size and the wei ht of the horse. ere is no limitation with regard to whether the antigenic substances are taken from animals of the same species as the animal inoculated Germany on May 8,1922), and of which,

roportion to the Application filed August c, was. Serial no. seam.

or not, nor need they be of cros ies or genera of any similar kind. Liv y action takes place within the animal, even fever and other symptoms of illness arise. When the latter has faded away a new inoculation can be carried out again in properly regulated proportion of mixture and when thereac tion of this again has faded further inoculations can be performed carefully controlling the temperature and the other behaviour of the animal until it must be assumed that about the maximum of concentration of an tidotes a ainst the germ cells in the blood is arrive at. state suitable for producing the required A second example for producing such testicles were inoculated (fresh).

As to the effect of the two different kinds of germ cells singly or in combination the followingis to be remarked:

It has been found out by the inventors that when the patient is to be treated with serum for the purpose of curing cancer, which serum is ained by the inoculation of ovarium from t e inoculated animal the cancer was affected in this way that a decomposition and a liquefaction set in. If, however, a serum is used which has been gained by inoculatin testicle substance the effect is the reverse, t at is to say, the cancer dries up and its growth is discontinued (encapsulation) For effectively overcoming malignant owths, such as cancer or a cancerous tumor it is of great im ortance to avail oneself of both manners 0 operation simultaneously. Therefore it is of advantage to produce a serum, which has the property of that of ovarium serum as well as of testicle serum. Taking this into consideration the manner pf carrying out the invention may be as folows:

According to the weight of the animal,

by which it is intended to produce the serum, the prescribed mixture of overium-substance and testicle substance is produced for instance in the proportion of 1:4, which in accurately determined amounts is introduced into the animal during the run of several weeks according to the reaction testified. When it has been foundthat the blood of the animal has adopted such wncentmtion of mixed anti cues that a curative serum can be gained t erefrom, the blood is drawn ofi-and worked into serum in usual manner.

We claim: 1. A method for producing an ant-item's mo est serum, compriming inoculating ovarium enhstence and testicle substance into the organism of animal, and gaini the sermn from the blood of the thus inocfiited animal.

2. A method for producing an antitoxic serum, comprising inoculating a mixture of one part of substance of ovarium and four parts of substance from testicles into the organism of an animal and gaining the serum from the blood of the thus inoculated animal.