GB453917A - Process for the manufacture of curative sera, vaccines and preparations from animal organs - Google Patents
Process for the manufacture of curative sera, vaccines and preparations from animal organsInfo
- Publication number
- GB453917A GB453917A GB8133/35A GB813335A GB453917A GB 453917 A GB453917 A GB 453917A GB 8133/35 A GB8133/35 A GB 8133/35A GB 813335 A GB813335 A GB 813335A GB 453917 A GB453917 A GB 453917A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparations
- sera
- vaccines
- specific
- curative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 5
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 210000001557 animal structure Anatomy 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 102000057297 Pepsin A Human genes 0.000 abstract 2
- 108090000284 Pepsin A Proteins 0.000 abstract 2
- 230000029087 digestion Effects 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 229940111202 pepsin Drugs 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 206010002199 Anaphylactic shock Diseases 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 239000005862 Whey Substances 0.000 abstract 1
- 102000007544 Whey Proteins Human genes 0.000 abstract 1
- 108010046377 Whey Proteins Proteins 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 206010040400 serum sickness Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001256 tonic effect Effects 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Curative albuminous preparations suitable for administration by the mouth are obtained from vaccines, specific sera, preparations of animal organs, normal serum, and whey by a process of partial digestion with pepsin. The original albuminous substance is treated in an incubator with pepsin and hydrochloric acid and the digestion is stopped when a test shows that the liquid gives a negative nitric acid reaction, but still gives a positive biuret reaction. The mixture is then adjusted to the iso-electric point, the precipitate formed is removed, and if necessary the liquid is filtered and sterilized. Examples relate to the treatment of tuberculosis serum prepared according to Specification 297,675, [Class 81 (i)], and of cancerous tissue. It is stated that sera and vaccines retain their specific action, but that serum sickness and anaphylactic shock are avoided. Non-specific albumens yield tonic and blood-building preparations. The preparations may be taken mixed with milk. Specifications 12523/09, 225,585, [both in Class 81 (i)], 387,641, and 438,592, also are referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8133/35A GB453917A (en) | 1935-03-15 | 1935-03-15 | Process for the manufacture of curative sera, vaccines and preparations from animal organs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8133/35A GB453917A (en) | 1935-03-15 | 1935-03-15 | Process for the manufacture of curative sera, vaccines and preparations from animal organs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB453917A true GB453917A (en) | 1936-09-15 |
Family
ID=9846377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8133/35A Expired GB453917A (en) | 1935-03-15 | 1935-03-15 | Process for the manufacture of curative sera, vaccines and preparations from animal organs |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB453917A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4335099A (en) * | 1975-05-29 | 1982-06-15 | The Green Cross Corporation | Employment of enteric coated IgA for hypoproteinemia in intestinal infectious diseases |
-
1935
- 1935-03-15 GB GB8133/35A patent/GB453917A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4335099A (en) * | 1975-05-29 | 1982-06-15 | The Green Cross Corporation | Employment of enteric coated IgA for hypoproteinemia in intestinal infectious diseases |
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