US10398907B2 - Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual - Google Patents

Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual Download PDF

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Publication number
US10398907B2
US10398907B2 US14/912,004 US201414912004A US10398907B2 US 10398907 B2 US10398907 B2 US 10398907B2 US 201414912004 A US201414912004 A US 201414912004A US 10398907 B2 US10398907 B2 US 10398907B2
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individual
magnet
permanent magnet
magnetic
head mount
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US14/912,004
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US20160193476A1 (en
Inventor
Santosh A. Helekar
Henning U. Voss
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Cornell University
Methodist Hospital
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Cornell University
Methodist Hospital
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Priority claimed from US13/829,349 external-priority patent/US9456784B2/en
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Priority to US14/912,004 priority Critical patent/US10398907B2/en
Publication of US20160193476A1 publication Critical patent/US20160193476A1/en
Assigned to THE METHODIST HOSPITAL reassignment THE METHODIST HOSPITAL ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HELEKAR, SANTOSH A.
Assigned to THE METHODIST HOSPITAL reassignment THE METHODIST HOSPITAL ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VOSS, HENNING U.
Assigned to THE METHODIST HOSPITAL reassignment THE METHODIST HOSPITAL ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HELEKAR, SANTOSH A.
Assigned to CORNELL UNIVERSITY reassignment CORNELL UNIVERSITY CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNOR'S ADDRESS AND ASSIGNEE'S DATA PREVIOUSLY RECORDED ON REEL 039290 FRAME 0126. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Assignors: VOSS, HENNING U.
Assigned to CORNELL UNIVERSITY reassignment CORNELL UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VOSS, HENNING U.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/12—Magnetotherapy using variable magnetic fields obtained by mechanical movement
    • A61B5/0476—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets

Definitions

  • This invention relates to Transcranial Magnetic Stimulation (TMS) in general, and more particularly to novel methods and apparatus for providing transcranial magnetic stimulation to an individual.
  • TMS Transcranial Magnetic Stimulation
  • the present invention provides a novel method and apparatus for providing Transcranial Magnetic Stimulation (TMS) to an individual.
  • TMS Transcranial Magnetic Stimulation
  • the present invention comprises the provision and use of novel TMS apparatus which allows the spatial, strength and temporal characteristics of the magnetic field generated by the TMS apparatus to be custom tailored for each individual, whereby to provide individual-specific TMS therapy and/or diagnostic testing. It also affords greater flexibility in open-ended investigations of brain function in neuroscience research.
  • each of the magnet assemblies is configured to provide a rapidly changing magnetic field of at least 500-600 Tesla/second.
  • each of the magnet assemblies is configured to provide a rapidly changing magnetic field of at least 500-600 Tesla/second.
  • apparatus for creating a variable magnetic field in a region of space comprising:
  • FIGS. 1 and 2 are schematic views illustrating novel apparatus for providing Transcranial Magnetic Stimulation (TMS) to an individual;
  • TMS Transcranial Magnetic Stimulation
  • FIG. 3 is a schematic view illustrating how selective ones of the magnet assemblies of the TMS apparatus of FIGS. 1 and 2 may be activated at selected times so as to provide the desired TMS therapy to an individual, diagnostic testing and/or investigative protocol in neuroscience research;
  • FIG. 4 is a schematic view illustrating the physics of magnetic stimulation in a conductor
  • FIG. 5 is a schematic view illustrating the biophysics of magnetic stimulation of a brain
  • FIG. 6 is a table illustrating some of the advantages of the present invention over conventional TMS
  • FIG. 12 is a schematic view illustrating still another form of magnet shield shutter mechanism.
  • FIG. 13 is a schematic view illustrating novel apparatus for providing TMS to an individual, wherein the magnet assemblies further comprise a servomotor for changing the orientation of the rotating permanent magnet.
  • head mount 10 comprises a soft, form-fitting skull cap adapted to cover the head of the individual while leaving the face and ears of the individual exposed.
  • Head mount 10 is intended to provide a stable support for the aforementioned magnet assemblies 15 , and to that end head mount 10 preferably comprises a textile construct (e.g., woven, braided or knit fibers) that has a stable structure but which can breathe (for comfort of the individual).
  • the head mount could be constructed of other materials such as soft plastic.
  • Head mount 10 preferably includes a chin strap 30 so that the head mount can be fastened onto the head of an individual with light tension, whereby to ensure that the head mount maintains a fixed position on the head of the individual.
  • TMS apparatus 5 also comprises a computerized controller 25 for independently controlling the operation of each of the magnet assemblies 15 , i.e., turning motors 45 on or off, regulating the speeds of motor rotation, etc.
  • Leads 20 connect computerized controller 25 to each of the magnet assemblies 15 .
  • TMS therapy and/or testing is to be applied to the individual, the individual puts on head mount 10 , the clinician or investigator mounts the appropriate number of magnet assemblies 15 to head mount 10 , positioning those magnet assemblies at the appropriate locations on head mount 10 , and then computerized controller 25 thereafter controls which magnet assemblies 15 have their magnets rotated when, and at what speed.
  • computerized controller 25 thereafter controls which magnet assemblies 15 have their magnets rotated when, and at what speed.
  • head mount 10 may include a plurality of electrodes 60 for monitoring changes in the electrical activity of the brain of the individual.
  • magnet assemblies 15 may be constructed so that magnets 50 are moved longitudinally, rather than rotationally, by actuators (e.g., linear actuators) in order to produce a rapidly changing magnetic field. See, for example, FIG. 7 , where the actuators comprise solenoids 65 to move magnets 50 rapidly so as to create the changing magnetic field utilized in the present invention.
  • actuators e.g., linear actuators
  • the magnet assembly may comprise a moving permanent magnet to provide the desired changing magnetic field and the magnetic shield shutter mechanism may be omitted; in another form of the invention, the magnet assembly may comprise a stationary permanent magnet and the magnetic shield shutter mechanism may be used to provide the desired changing magnetic field; and in another form of the invention, the magnet assembly may comprise a moving permanent magnet to provide a changing magnetic field and the magnetic shield shutter mechanism may be used to modulate the changing magnetic field created by the moving magnet so as to provide a desired changing magnetic field at the anatomical location.
  • magnet assembly 15 and its associated magnetic shield shutter mechanism 100 are preferably configured as a unit, with magnet assembly 15 and its associated magnetic shield shutter mechanism 100 being contained in a housing 122 , such that when that magnet assembly 15 is mounted to head mount 10 (e.g., by mounting housing 122 to head mount 10 ), its associated magnetic shield shutter mechanism is also mounted to head mount 10 .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Magnetic Treatment Devices (AREA)
US14/912,004 2013-03-14 2014-08-15 Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual Active 2034-04-13 US10398907B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/912,004 US10398907B2 (en) 2013-03-14 2014-08-15 Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13/829,349 US9456784B2 (en) 2013-03-14 2013-03-14 Method and apparatus for providing transcranial magnetic stimulation (TMS) to a patient
US201361866447P 2013-08-15 2013-08-15
USPCT/US2014/027900 2014-03-14
PCT/US2014/027900 WO2014152827A2 (en) 2013-03-14 2014-03-14 Method and apparatus for providing transcranial magnetic stimulation (tms) to a patient
US14/912,004 US10398907B2 (en) 2013-03-14 2014-08-15 Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual
PCT/US2014/051340 WO2015023980A2 (en) 2013-08-15 2014-08-15 Method and apparatus for ppoviding transcranial magnetic stimulation (tms) to an individual

Related Parent Applications (2)

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PCT/US2014/027900 Continuation-In-Part WO2014152827A2 (en) 2013-03-14 2014-03-14 Method and apparatus for providing transcranial magnetic stimulation (tms) to a patient
PCT/US2014/051340 A-371-Of-International WO2015023980A2 (en) 2013-03-14 2014-08-15 Method and apparatus for ppoviding transcranial magnetic stimulation (tms) to an individual

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US16/556,817 Continuation US11491341B2 (en) 2013-03-14 2019-08-30 Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual

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US10398907B2 true US10398907B2 (en) 2019-09-03

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US (1) US10398907B2 (ja)
EP (1) EP3033007B1 (ja)
CN (2) CN105813559B (ja)
BR (1) BR112016003147B1 (ja)
ES (1) ES2755998T3 (ja)
PL (1) PL3033007T3 (ja)
WO (1) WO2015023980A2 (ja)

Cited By (2)

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US11571585B2 (en) 2020-06-19 2023-02-07 The Methodist Hospital Method and apparatus for oncomagnetic treatment
US11730970B2 (en) 2013-03-14 2023-08-22 The Methodist Hospital Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual

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US9456784B2 (en) 2013-03-14 2016-10-04 The Methodist Hospital Method and apparatus for providing transcranial magnetic stimulation (TMS) to a patient
PL3033007T3 (pl) 2013-08-15 2020-04-30 The Methodist Hospital Urządzenie do przezczaszkowej stymulacji magnetycznej (TMS) pacjenta
US20160331990A1 (en) * 2014-01-15 2016-11-17 Hossam Abdel Salam El Sayed Mohamed Uni-polar rotating electromagnetic medical apparatus and methods of use
US10773096B2 (en) * 2015-04-02 2020-09-15 University Of Maryland, Baltimore Methods and systems for controlling magnetic fields and magnetic field induced current
US20170151442A1 (en) * 2015-11-05 2017-06-01 Warren Winslow Walborn Hair loss regrowth and hair treatment device
KR101891154B1 (ko) * 2016-01-29 2018-08-23 이영규 가정용 tms 의료 기기
ES2635311B1 (es) * 2016-03-31 2018-07-19 Universitat De València Sistema para el direccionamiento de células hacia regiones internas objetivo de un cuerpo humano o animal, y programa de ordenador
CN109475749B (zh) * 2016-05-05 2023-05-12 卫理公会医院 用于向个体提供经颅磁刺激（tms）的方法和设备
CN106110499A (zh) * 2016-08-10 2016-11-16 于华 脑血管穴位刺激软化装置
US10639494B2 (en) * 2016-09-20 2020-05-05 Rhode Island Board Of Education Time-varying magnetic field therapy using multistable latching mechanisms
JP7460155B2 (ja) * 2018-11-15 2024-04-02 公立大学法人広島市立大学 脳機能計測装置及び脳機能計測方法
US10981016B2 (en) * 2019-03-13 2021-04-20 Seraya Medical Systems LLC Identifiable magnetic assemblies and communications
JP7436337B2 (ja) * 2019-09-26 2024-02-21 ピップ株式会社 変動磁場発生装置
WO2021060191A1 (ja) * 2019-09-26 2021-04-01 ピップ株式会社 変動磁場発生装置
US11052262B1 (en) * 2019-12-30 2021-07-06 Seraya Medical Systems LLC Stimulation of subcortical brain regions using transcranial rotating permanent magnetic stimulation (TRPMS)

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