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Publication of UA99722C2publicationCriticalpatent/UA99722C2/en
The invention relates to the fused protein containing PRAME, heterological fused partner protein risen from protein D, and contains amino acids 20-127 of D protein, and also contains additional amino acids Met-Asp-Pro at the N-terminus of sequence of fused partner sequence, where the mentioned fused partner protein does not have secretion sequence or signal sequence of D protein. The present invention relates to nucleic acid sequence, vector, host cell, vaccine, containing the mentioned fused protein, and using thereof for immunotherapeutic cancer treatment.