UA98605C2 - Новый способ предотвращения или лечения инфекции m. tuberculosis - Google Patents

Новый способ предотвращения или лечения инфекции m. tuberculosis

Info

Publication number
UA98605C2
UA98605C2 UAA200711587A UAA200711587A UA98605C2 UA 98605 C2 UA98605 C2 UA 98605C2 UA A200711587 A UAA200711587 A UA A200711587A UA A200711587 A UAA200711587 A UA A200711587A UA 98605 C2 UA98605 C2 UA 98605C2
Authority
UA
Ukraine
Prior art keywords
tuberculosis infection
fusion protein
preventing
treating
mtb72f
Prior art date
Application number
UAA200711587A
Other languages
English (en)
Ukrainian (uk)
Inventor
Реа Колер
Ив Лобет
Стивен Рид
Original Assignee
ГлаксоСмитКлайн Байолоджикалз с.а.
Инфекшес Дизиз Рисерч Инститьют (Идри)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ГлаксоСмитКлайн Байолоджикалз с.а., Инфекшес Дизиз Рисерч Инститьют (Идри) filed Critical ГлаксоСмитКлайн Байолоджикалз с.а.
Publication of UA98605C2 publication Critical patent/UA98605C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Abstract

Изобретение относится к способам предотвращения реактивации активной или латентной инфекций М. tuberculosis путем введения фармацевтической композиции, которая включает нуклеиновую кислоту, которая кодирует Mtb72f слитый белок, или Mtb72f слитый белок, или его иммуногенный фрагмент, например, вместе с адьювантом. Mtb72f нуклеиновая кислота или слитый белок могут вводиться с одним или более из химиотерапевтических агентов, эффективных против инфекции М. tuberculosis. Способы также обеспечивают сокращение времени курса химиотерапевтического режима против инфекции М. tuberculosis.
UAA200711587A 2005-04-29 2006-04-27 Новый способ предотвращения или лечения инфекции m. tuberculosis UA98605C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67654905P 2005-04-29 2005-04-29

Publications (1)

Publication Number Publication Date
UA98605C2 true UA98605C2 (ru) 2012-06-11

Family

ID=40006338

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201111598A UA107788C2 (en) 2005-04-29 2006-04-27 A fusion protein of m. tuberculosis
UAA200711587A UA98605C2 (ru) 2005-04-29 2006-04-27 Новый способ предотвращения или лечения инфекции m. tuberculosis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201111598A UA107788C2 (en) 2005-04-29 2006-04-27 A fusion protein of m. tuberculosis

Country Status (2)

Country Link
CN (1) CN105903008B (ru)
UA (2) UA107788C2 (ru)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2374620T3 (es) * 2000-06-20 2012-02-20 Corixa Corporation Antígeno mtb32a de mycobacterium tuberculosis con el sitio activo inactivado y proteínas de fusión de los mismos.
US20030175294A1 (en) * 2001-03-13 2003-09-18 Corixa Corporation Heterologous fusion protein constructs comprising a Leishmania antigen
AU2003213118A1 (en) * 2002-02-15 2003-09-09 Corixa Corporation Fusion proteins of mycobacterium tuberculosis

Also Published As

Publication number Publication date
CN105903008B (zh) 2020-01-03
CN105903008A (zh) 2016-08-31
UA107788C2 (en) 2015-02-25

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