UA95939C2 - Thieno-pyridine derivatives as mek inhibitors - Google Patents

Thieno-pyridine derivatives as mek inhibitors

Info

Publication number
UA95939C2
UA95939C2 UAA200809945A UAA200809945A UA95939C2 UA 95939 C2 UA95939 C2 UA 95939C2 UA A200809945 A UAA200809945 A UA A200809945A UA A200809945 A UAA200809945 A UA A200809945A UA 95939 C2 UA95939 C2 UA 95939C2
Authority
UA
Ukraine
Prior art keywords
thieno
pyridine derivatives
mek inhibitors
substituted
mek
Prior art date
Application number
UAA200809945A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Мартин Клайв Хатчингс
Сарра Кетрин Арчибальд
Даниэль Кристофер Брукингс
Джереми Мартин Давис
Джеймс Эндрю Джонсон
Барри Джон Лангхам
Джуди Шарлотт Нейсс
Original Assignee
Юсиби Фарма, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юсиби Фарма, С.А. filed Critical Юсиби Фарма, С.А.
Publication of UA95939C2 publication Critical patent/UA95939C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

A series of thieno[2,3-b]pyridine derivatives which are substituted in the 2- position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.
UAA200809945A 2006-01-31 2007-01-30 Thieno-pyridine derivatives as mek inhibitors UA95939C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0601962.4A GB0601962D0 (en) 2006-01-31 2006-01-31 Therapeutic agents

Publications (1)

Publication Number Publication Date
UA95939C2 true UA95939C2 (en) 2011-09-26

Family

ID=36100789

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200809945A UA95939C2 (en) 2006-01-31 2007-01-30 Thieno-pyridine derivatives as mek inhibitors

Country Status (27)

Country Link
US (3) US8283359B2 (en)
EP (1) EP1981892B1 (en)
JP (1) JP5249787B2 (en)
KR (1) KR101446919B1 (en)
CN (1) CN101379067B (en)
AU (1) AU2007211377B2 (en)
BR (1) BRPI0708016B1 (en)
CA (1) CA2640594C (en)
CY (1) CY1115404T1 (en)
DK (1) DK1981892T3 (en)
EA (1) EA016128B1 (en)
EC (1) ECSP088704A (en)
ES (1) ES2471970T3 (en)
GB (1) GB0601962D0 (en)
HK (1) HK1125924A1 (en)
HR (1) HRP20140503T1 (en)
IL (1) IL192603A (en)
MY (1) MY146387A (en)
NO (1) NO341064B1 (en)
NZ (1) NZ569638A (en)
PL (1) PL1981892T3 (en)
PT (1) PT1981892E (en)
RS (1) RS53342B (en)
SI (1) SI1981892T1 (en)
UA (1) UA95939C2 (en)
WO (1) WO2007088345A1 (en)
ZA (1) ZA200807447B (en)

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GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
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GB0811304D0 (en) * 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
JP5503930B2 (en) * 2009-09-18 2014-05-28 住友化学株式会社 Method for purifying 3-amino-1-tert-butoxycarbonylpiperidine and citrate salt thereof
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EP3327144B1 (en) 2013-02-25 2020-03-25 Novartis AG Novel androgen receptor mutation
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CA3063535A1 (en) 2017-05-19 2018-11-22 Nflection Therapeutics, Inc. Fused heteroaromatic-aniline compounds for treatment of dermal disorders
CN109836434B (en) * 2017-11-27 2020-09-25 上海宇耀生物科技有限公司 Thieno-ring compound and synthesis method and application thereof
MA55143A (en) * 2018-11-20 2021-09-29 H Lee Moffitt Cancer Center & Res Institute Inc ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR THE TREATMENT OF SKIN CANCERS
US11572344B2 (en) 2018-11-20 2023-02-07 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN111138449B (en) * 2020-01-15 2022-11-29 四川大学华西医院 Preparation of dual-targeting ERK1 and ERK5 inhibitors and anti-tumor application thereof
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
GB202205203D0 (en) 2022-04-08 2022-05-25 UCB Biopharma SRL Combination with inhibitor

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Also Published As

Publication number Publication date
HRP20140503T1 (en) 2014-07-04
ECSP088704A (en) 2008-09-29
BRPI0708016A2 (en) 2011-05-17
EA016128B1 (en) 2012-02-28
CA2640594A1 (en) 2007-08-09
HK1125924A1 (en) 2009-08-21
JP2009525317A (en) 2009-07-09
DK1981892T3 (en) 2014-06-23
IL192603A (en) 2013-12-31
CN101379067A (en) 2009-03-04
BRPI0708016B1 (en) 2021-07-06
NO341064B1 (en) 2017-08-14
KR20080095870A (en) 2008-10-29
CY1115404T1 (en) 2017-01-04
US8394822B2 (en) 2013-03-12
JP5249787B2 (en) 2013-07-31
SI1981892T1 (en) 2014-07-31
US20120329774A1 (en) 2012-12-27
MY146387A (en) 2012-08-15
EA200801684A1 (en) 2009-04-28
AU2007211377B2 (en) 2012-03-01
US8604051B2 (en) 2013-12-10
PL1981892T3 (en) 2014-08-29
KR101446919B1 (en) 2014-10-07
US20090149437A1 (en) 2009-06-11
AU2007211377A1 (en) 2007-08-09
US20130150573A1 (en) 2013-06-13
ES2471970T3 (en) 2014-06-27
EP1981892B1 (en) 2014-03-12
IL192603A0 (en) 2009-02-11
ZA200807447B (en) 2009-11-25
CN101379067B (en) 2011-03-23
PT1981892E (en) 2014-06-23
US8283359B2 (en) 2012-10-09
CA2640594C (en) 2014-12-23
WO2007088345A1 (en) 2007-08-09
NO20083739L (en) 2008-08-29
NZ569638A (en) 2010-08-27
EP1981892A1 (en) 2008-10-22
RS53342B (en) 2014-10-31
GB0601962D0 (en) 2006-03-15

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