UA93489C2 - Heterocyclic compounds as ccr2b antagonists - Google Patents

Heterocyclic compounds as ccr2b antagonists

Info

Publication number
UA93489C2
UA93489C2 UAA200706266A UAA200706266A UA93489C2 UA 93489 C2 UA93489 C2 UA 93489C2 UA A200706266 A UAA200706266 A UA A200706266A UA A200706266 A UAA200706266 A UA A200706266A UA 93489 C2 UA93489 C2 UA 93489C2
Authority
UA
Ukraine
Prior art keywords
heterocyclic compounds
formula
yand
alkyl
ccr2b
Prior art date
Application number
UAA200706266A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Джастин Ферфилд Бауэр
Джеффри Филип Пойзер
Пол Тернер
Дейвид Вотерсон
Джон Винтер
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA93489C2 publication Critical patent/UA93489C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compounds of formula (I) Q-L-W-C(=X)-Z-P wherein Q is an amine of the formula -N(R)(R); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Yand Ywhich are linked to groups L and C(X) respectively and Yand Yare independently selected from N and C; X is O, N, N-CN or S; Z is NR; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.
UAA200706266A 2004-12-24 2005-12-19 Heterocyclic compounds as ccr2b antagonists UA93489C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0428327A GB0428327D0 (en) 2004-12-24 2004-12-24 Method

Publications (1)

Publication Number Publication Date
UA93489C2 true UA93489C2 (en) 2011-02-25

Family

ID=34130900

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200706266A UA93489C2 (en) 2004-12-24 2005-12-19 Heterocyclic compounds as ccr2b antagonists

Country Status (4)

Country Link
CN (1) CN101128427B (en)
GB (1) GB0428327D0 (en)
UA (1) UA93489C2 (en)
ZA (1) ZA200705159B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100152197A1 (en) * 2008-12-15 2010-06-17 Astrazeneca Ab (4-tert-butylpiperazin-2-yl)(piperazin-1-yl)methanone-n-carboxamide derivatives
AU2020343737A1 (en) * 2019-09-05 2022-03-31 Lunan Pharmaceutical Group Corporation MAGL inhibitor, preparation method therefor and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519449A1 (en) * 1991-06-21 1992-12-23 Boehringer Mannheim Italia S.P.A. 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract
WO2002038547A1 (en) * 2000-11-13 2002-05-16 Glaxosmithkline Spa Quinoline derivatives as nk-3 and nk-2 antagonists
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
WO2002079151A1 (en) * 2001-03-29 2002-10-10 Smithkline Beecham P.L.C. 3-substituted indoels or fused pyrroles as antagonists of the chemokine mcp-1 (ccr2b) receptor
EP1558599A4 (en) * 2002-10-30 2007-06-27 Merck & Co Inc Heteroarylpiperidine modulators of chemokine receptor activity
FR2872813B1 (en) * 2004-07-09 2007-01-19 Sanofi Synthelabo 2-CARBAMID-4-PHENYLTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Also Published As

Publication number Publication date
ZA200705159B (en) 2008-06-25
CN101128427A (en) 2008-02-20
GB0428327D0 (en) 2005-02-02
CN101128427B (en) 2013-03-27

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