UA93377C2 - Macrocyclic inhibitors of hepatitis c virus - Google Patents
Macrocyclic inhibitors of hepatitis c virusInfo
- Publication number
- UA93377C2 UA93377C2 UAA200800492A UAA200800492A UA93377C2 UA 93377 C2 UA93377 C2 UA 93377C2 UA A200800492 A UAA200800492 A UA A200800492A UA A200800492 A UAA200800492 A UA A200800492A UA 93377 C2 UA93377 C2 UA 93377C2
- Authority
- UA
- Ukraine
- Prior art keywords
- calkyl
- calkylenecarbocyclyl
- ris
- hydrogen
- calkyleneheterocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereof wherein A is OR , NHS(=O)R; wherein; Ris hydrogen, C-Calkyl, C-Calkylenecarbocyclyl, C-Calkylene-heterocyclyl; Ris C-Calkyl, C-Calkylenecarbocyclyl, C-Calkylenehetcrocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; --- deonotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C-Calkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C-Calkyl, C-Cа1kоху, hydroxyl, halo, haloC-Calkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C-Calkyl-carbonylamino, C-Calkylenecarbocyclyl and C-Calkyleneheterocyclyl; Ris hydrogen, C-Calkyl, C-CalkoxyC-Calkyl or C-Ccycloalkyl; R is hydrogen, C-Calkyl, C-Calkoxy, C-Calkylenecarbocyclyl, C-Calkyleneheterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05107057 | 2005-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA93377C2 true UA93377C2 (en) | 2011-02-10 |
Family
ID=35695633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200800492A UA93377C2 (en) | 2005-07-29 | 2006-07-28 | Macrocyclic inhibitors of hepatitis c virus |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101233131B (en) |
UA (1) | UA93377C2 (en) |
ZA (1) | ZA200800859B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103387509B (en) * | 2012-05-11 | 2016-06-08 | 重庆博腾制药科技股份有限公司 | The preparation method of a kind of HCV protease inhibitor intermediate |
CN112358450A (en) * | 2020-11-19 | 2021-02-12 | 南京艾康生物科技有限公司 | Synthesis method of 4- (benzyloxy) -2-methyl-1H-benzo [ d ] imidazole-6-carboxylic acid |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
ES2361997T3 (en) * | 2003-09-22 | 2011-06-27 | Boehringer Ingelheim International Gmbh | ACTIVE MACROCYCLIC PEPTIDES AGAINST THE VIRUS OF HEPATITIS C. |
-
2006
- 2006-07-28 CN CN2006800278839A patent/CN101233131B/en not_active Expired - Fee Related
- 2006-07-28 UA UAA200800492A patent/UA93377C2/en unknown
-
2008
- 2008-01-28 ZA ZA200800859A patent/ZA200800859B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN101233131A (en) | 2008-07-30 |
ZA200800859B (en) | 2009-06-24 |
CN101233131B (en) | 2011-06-08 |
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