UA93030C2 - Способ получения клопидогрела (варианты) и промежуточные соединения - Google Patents
Способ получения клопидогрела (варианты) и промежуточные соединенияInfo
- Publication number
- UA93030C2 UA93030C2 UAA200611996A UAA200611996A UA93030C2 UA 93030 C2 UA93030 C2 UA 93030C2 UA A200611996 A UAA200611996 A UA A200611996A UA A200611996 A UAA200611996 A UA A200611996A UA 93030 C2 UA93030 C2 UA 93030C2
- Authority
- UA
- Ukraine
- Prior art keywords
- production
- clopidogrel
- intermediates
- variants
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Semiconductor Lasers (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Saccharide Compounds (AREA)
Abstract
Данное изобретение касается способов получения соединения общей формулы (Иа), (Иа)в которой X представляет собой атом галогена, или его фармацевтически приемлемой соли, в которых соединение формулы (II), (ИИ)где X имеет значения, указанные выше, и Y и Z каждый независимо представляют собой уходящую группу, подвергают реакции с оптически активным аминоспиртом для получения первой смеси диастереомеров, которую в дальнейшем превращают в соединения (Иа). Также изобретение касается промежуточных соединений.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04009280A EP1589019B1 (de) | 2004-04-20 | 2004-04-20 | Stereoselektives Verfahren zur Herstellung von Clopidogrel |
Publications (1)
Publication Number | Publication Date |
---|---|
UA93030C2 true UA93030C2 (ru) | 2011-01-10 |
Family
ID=34924660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200611996A UA93030C2 (ru) | 2004-04-20 | 2004-12-03 | Способ получения клопидогрела (варианты) и промежуточные соединения |
Country Status (20)
Country | Link |
---|---|
US (2) | US7507827B2 (ru) |
EP (2) | EP1589019B1 (ru) |
JP (1) | JP2007533671A (ru) |
CN (1) | CN100522970C (ru) |
AT (2) | ATE404566T1 (ru) |
AU (1) | AU2004319901A1 (ru) |
BR (1) | BRPI0418760A (ru) |
CA (1) | CA2563662A1 (ru) |
CY (2) | CY1107908T1 (ru) |
DE (2) | DE502004007831D1 (ru) |
DK (2) | DK1589019T3 (ru) |
ES (2) | ES2309416T3 (ru) |
HR (1) | HRP20080091T3 (ru) |
NO (1) | NO20065313L (ru) |
PL (2) | PL1589019T3 (ru) |
PT (2) | PT1589019E (ru) |
RU (1) | RU2369610C2 (ru) |
SI (2) | SI1589019T1 (ru) |
UA (1) | UA93030C2 (ru) |
WO (1) | WO2005113559A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2909377A1 (fr) | 2006-12-05 | 2008-06-06 | Arkema France | Procede de synthese d'esters (meth)acryliques catalyse par un titanate de polyol |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196334B (it) * | 1984-11-22 | 1988-11-16 | Alfa Chem Ital | Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici |
DE4428531A1 (de) * | 1994-08-12 | 1996-02-15 | Boehringer Ingelheim Kg | Neue enantiomerenreine Pyridylcycloalkylethylamine und deren Salze sowie Verfahren zu ihrer Herstellung |
HU225503B1 (en) * | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
FR2769313B1 (fr) * | 1997-10-06 | 2000-04-21 | Sanofi Sa | Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese |
WO2001058843A1 (fr) * | 2000-02-08 | 2001-08-16 | Asahi Kasei Kabushiki Kaisha | Procede de preparation d'alcools secondaires optiquement actifs possedant des groupes fonctionnels azote ou oxygene |
GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
-
2004
- 2004-04-20 PL PL04009280T patent/PL1589019T3/pl unknown
- 2004-04-20 DE DE502004007831T patent/DE502004007831D1/de not_active Expired - Lifetime
- 2004-04-20 EP EP04009280A patent/EP1589019B1/de not_active Expired - Lifetime
- 2004-04-20 DK DK04009280T patent/DK1589019T3/da active
- 2004-04-20 SI SI200430861T patent/SI1589019T1/sl unknown
- 2004-04-20 AT AT04009280T patent/ATE404566T1/de not_active IP Right Cessation
- 2004-04-20 PT PT04009280T patent/PT1589019E/pt unknown
- 2004-04-20 ES ES04009280T patent/ES2309416T3/es not_active Expired - Lifetime
- 2004-12-03 RU RU2006137112/04A patent/RU2369610C2/ru not_active IP Right Cessation
- 2004-12-03 CA CA002563662A patent/CA2563662A1/en not_active Abandoned
- 2004-12-03 WO PCT/EP2004/013773 patent/WO2005113559A1/de active IP Right Grant
- 2004-12-03 ES ES04803495T patent/ES2300854T3/es active Active
- 2004-12-03 DE DE502004006368T patent/DE502004006368D1/de active Active
- 2004-12-03 PT PT04803495T patent/PT1737868E/pt unknown
- 2004-12-03 JP JP2007508735A patent/JP2007533671A/ja active Pending
- 2004-12-03 EP EP04803495A patent/EP1737868B1/de active Active
- 2004-12-03 AU AU2004319901A patent/AU2004319901A1/en not_active Abandoned
- 2004-12-03 BR BRPI0418760-1A patent/BRPI0418760A/pt not_active Application Discontinuation
- 2004-12-03 US US11/587,124 patent/US7507827B2/en not_active Expired - Fee Related
- 2004-12-03 PL PL04803495T patent/PL1737868T3/pl unknown
- 2004-12-03 DK DK04803495T patent/DK1737868T3/da active
- 2004-12-03 CN CNB2004800433958A patent/CN100522970C/zh not_active Expired - Fee Related
- 2004-12-03 AT AT04803495T patent/ATE387454T1/de active
- 2004-12-03 SI SI200430682T patent/SI1737868T1/sl unknown
- 2004-12-03 UA UAA200611996A patent/UA93030C2/ru unknown
-
2006
- 2006-11-20 NO NO20065313A patent/NO20065313L/no not_active Application Discontinuation
-
2008
- 2008-03-04 HR HR20080091T patent/HRP20080091T3/xx unknown
- 2008-03-18 CY CY20081100304T patent/CY1107908T1/el unknown
- 2008-10-02 CY CY20081101094T patent/CY1108391T1/el unknown
-
2009
- 2009-02-10 US US12/368,967 patent/US7799952B2/en not_active Expired - Fee Related
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