UA9258U - Method for treating post-burn scars - Google Patents

Abstract

The method for treating post-burn scars comprises the topical application of the pharmacologic composition containing heparin, derivatives of the carboxylic acids, aspirin, and indometacin with the fatty base.

Description

Description of the invention

The useful model relates to medicine, in particular to therapy methods and can be used for the treatment of 2 scars of different genesis.

The formation of scars is associated with the fact that the wound surface is an area of high rates of cell proliferation.

At the same time, metabolic processes take place at speeds higher than usual (normal) speeds, which can lead to the appearance of erroneous sequences of amino acids during the synthesis of protein macromolecules. That is, some amino acid residues that make up a macromolecule can be omitted, shifted or attached to 70 sequences that are not characteristic of a normal protein |Syzov V.M. Peculiarities of the structure and properties of collagen of human post-burn scars // Report. Academy of Sciences of the Ukrainian SSR Biological series, 1988 Mo111.

These protein systems can be "dissolved" by the enzyme system present in the human body - collagenase. Protein compounds formed in the wound tissue interact only with "embryonic" collagenase, which is practically absent in the adult body. Therefore, wound healing in elderly people is much worse than in children and adolescents. In order to heal (treat) scars, it is necessary to modify the existing collagenase to the structure (conformation) of "embryonic collagenase or to create a matrix on which the required structure will be created. Such modification is carried out with the help of pharmacological agents that create a kind of basis - a matrix for collagen.

Various means of pharmacological action applied to the affected areas are used for resorption (treatment) of scars. For example, the "Rescuer" balm, which is produced in Ukraine (Kharkov), contains the following components: 1. melted butter; 2. beeswax; 3. refined naphthenic oil; 29 4. purified turpentine oil; -o 5. tea tree essential oil; 6. lavender essential oil; 7. vitamin E; 8. pink essential oil. co

The main disadvantage of this method of treatment is that the drug mainly provides healing of wounds, and its scar reduction function is performed much worse. This is due to the fact that refined naphthenic oil practically does not create a matrix for collagen, and the fatty base, softening the skin, does not penetrate deep into the tissue. Thus, the drug does not sufficiently modify collagenase. F

The closest to the claimed method is the method of treatment using the drug 3o "Kontractubex", which is applied to the damaged surface. "Contracttubex" (Sopigasitsrekh. MegagnSo?, Yu 60318 Egapkiip/Maip) is designed specifically for the treatment of "colloid scars." It makes it possible to achieve success in the local treatment of scars of various types and origins.

Old and recent scars become smoother and less noticeable, and the tissue becomes more functional, elastic, and elastic. 70 "Contractubex" contains active ingredients: c 1. Sire extract: c» 2. Heparin;

Z. Halotoin.

These substances create a matrix for collagen, specifically affecting scars. They are contained in p 395 special fat-free water-soluble gel base, in which they are able to penetrate the skin without leaving a residue on the surface, but forming a protective film on the sensitive tissues of the scar. ko The main disadvantage of "Contractubex" is that it easily penetrates deep into the skin, but, having no fatty components, does not soften the skin. The treatment process has a long duration and a high cost (20g - UAH).

The basis of the proposed useful model is the task of developing a method of treating scars, which

IR e) 50 is superior to known methods in terms of therapeutic effect, for example, with the use of "Contractubex". In addition, it should be simpler and cheaper, which is achieved by the use of components that create a matrix for collagen, which are cheap ready-made medicinal products produced by the domestic industry.

The task is solved by the fact that in the method of treatment of post-burn scars, in which it is applied to

So" the surface of the wound is a pharmacological preparation containing heparin, the new thing is that the composition of the preparation additionally includes derivatives of carboxylic acids - aspirin and indomethacin in a weight ratio of 100:1 on a fat basis.

In addition, to increase the penetration of the drug into the skin, it is irradiated by the combined action of an electromagnetic field of the radio frequency range, modulated by a random frequency of a low range, and an electret matrix ("Oratory-bm" device). because a distinctive feature of the proposed method of treating scars is that aspirin and indomethacin on a fat basis are used together with electromagnetic radiation, which ensures better penetration of the drug into the skin.

Figures 1-4 show photographs of patients with post-burn scars before and after treatment according to the claimed method. because 2 subgroups were formed from the group of patients with post-lobular lesions, one of which was treated with the help of

"Contractubex", and the other - by the proposed method.

For each of the patients, who had post-burn scars in several places of the limbs, the method of treatment with the help of "Contractubex" ointment was applied to one affected area, and the proposed method of treatment was used to the other (nearby).

To use the proposed method of treatment, a preparation based on carboxylic acids was prepared, the components of which are: 1. aspirin 5 g 2. indomethacin 0.05 g 70 Z. hydrocortisone (suspension 2.590) b ml 4. heparin 2 ml 5. lanolin anhydrous 30 g

In this preparation, the matrix is formed on the basis of the benzene rings of aspirin, while indomethacin provides not only the structure of the matrix, but also coordination of the arrangement of hydrocontisone macromolecules. The coordinated structure of the matrix makes it necessary to observe the weight ratio of the components (88:1:76).

Preparations in the form of ointments were applied to the wound. The surface of the wound with the drug was treated with an electromagnetic signal of the radiofrequency range, modulated by a random frequency of a low range ("Oratory-6EM" device)M. Previous studies have shown that the use of the "Oratory-6M" device increases the effectiveness of the use of the "Kontractubex" drug.

Fig. 1 shows photographs of patient K., br. with a diagnosis of a post-burn scar before treatment, and Fig. 2 shows the result of treatment after 3 months, according to the claimed method.

Fig. 3 shows photographs of patient R., 17 years old. with a diagnosis of a post-burn scar before treatment, and Fig. 4 shows the result of treatment after 3 months, according to the claimed method.

As a result of conducted clinical studies, it was established that in the process of applying the proposed method of treatment, scar resorption occurs, as a rule, in 8,095 cases - during 2-3 courses of treatment (one course - 21 days). t

Claims (2)

The formula of the invention p 1. The method of treatment of post-burn scars, which includes applying to the surface of the wound a pharmacological t) preparation containing heparin, which differs in that the composition of the preparation additionally includes derivatives of carboxylic acids - aspirin (acetylsalicylic acid) and indomethacin in a weight ratio of 100:1 fat-based. (is) 2. The method of treating post-burn scars according to claim 17, which is characterized by the fact that the preparation on the surface of the wound is irradiated by the combined effect of an electromagnetic field of the radio frequency range, modulated by a random frequency of a low range, and an electret matrix. " - with ;" se) ime) 1 so 70 Su; 60 b5