UA89759C2 - Специфический связующий элемент, радиоактивно меченный 131и, который связывает человеческий ed-в фибронектина - Google Patents
Специфический связующий элемент, радиоактивно меченный 131и, который связывает человеческий ed-в фибронектинаInfo
- Publication number
- UA89759C2 UA89759C2 UAA200603803A UAA200603803A UA89759C2 UA 89759 C2 UA89759 C2 UA 89759C2 UA A200603803 A UAA200603803 A UA A200603803A UA A200603803 A UAA200603803 A UA A200603803A UA 89759 C2 UA89759 C2 UA 89759C2
- Authority
- UA
- Ukraine
- Prior art keywords
- binding member
- specific binding
- binds human
- human fibronectin
- radiolabelled
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Изобретение относится к специфическому связующему элементу, который связывает человеческий домен ED-B фибронектина, где специфический связующий элемент является меченным с помощью изотопаИ и включает мини-иммуноглобулин, слитый с ε-CH4 и димеризованный, который содержит гипервариабельные участки тяжелой и легкой цепи антитела L19. Изобретение также относится к способу получения указанного связующего элемента, композиции, которая его содержит, а также применению данного связующего элемента для производства лекарственного средства для лечения повреждения, связанного с патологическим ангиогенезом, для лечения опухолей и производства диагностического реагента.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03255633A EP1514561A1 (en) | 2003-09-10 | 2003-09-10 | Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA89759C2 true UA89759C2 (ru) | 2010-03-10 |
Family
ID=34130349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200603803A UA89759C2 (ru) | 2003-09-10 | 2004-09-01 | Специфический связующий элемент, радиоактивно меченный 131и, который связывает человеческий ed-в фибронектина |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20050074401A1 (ru) |
| EP (3) | EP1514561A1 (ru) |
| JP (1) | JP2007505065A (ru) |
| KR (1) | KR101129161B1 (ru) |
| CN (1) | CN100482285C (ru) |
| AT (1) | ATE499949T1 (ru) |
| AU (2) | AU2004269897B2 (ru) |
| BR (1) | BRPI0414272A (ru) |
| CA (1) | CA2536256C (ru) |
| CR (2) | CR8331A (ru) |
| DE (1) | DE602004031635D1 (ru) |
| DK (1) | DK1663320T3 (ru) |
| EA (1) | EA010653B1 (ru) |
| EC (1) | ECSP066499A (ru) |
| ES (1) | ES2361743T3 (ru) |
| HK (1) | HK1092375A1 (ru) |
| IL (1) | IL173560A0 (ru) |
| ME (1) | MEP13108A (ru) |
| NO (1) | NO20061619L (ru) |
| NZ (1) | NZ545640A (ru) |
| PL (1) | PL1663320T3 (ru) |
| PT (1) | PT1663320E (ru) |
| RS (1) | RS20060176A (ru) |
| SG (1) | SG162760A1 (ru) |
| SI (1) | SI1663320T1 (ru) |
| UA (1) | UA89759C2 (ru) |
| WO (1) | WO2005023318A1 (ru) |
| ZA (1) | ZA200602014B (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001242432B2 (en) * | 2000-02-24 | 2007-11-08 | Eidgenossische Technische Hochschule Zurich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| CN100535013C (zh) * | 2002-03-11 | 2009-09-02 | 菲洛根股份公司 | 应用抗体分子对肿瘤血管进行选择性定向 |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP2085095B1 (en) * | 2008-01-17 | 2012-03-07 | Philogen S.p.A. | Combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart |
| AU2015202204A1 (en) * | 2008-04-30 | 2015-05-14 | Immunogen, Inc. | Cross-linkers and their uses |
| KR101764081B1 (ko) * | 2008-04-30 | 2017-08-01 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| WO2011147762A2 (en) * | 2010-05-25 | 2011-12-01 | Bayer Pharma Aktiengesellschaft | Stabilized radiopharmaceutical composition |
| EP3029065B1 (en) * | 2013-06-06 | 2020-05-27 | Hefei Lifeon Pharmaceutical Co. Ltd. | Human antibody against ed-b domain of fibronectin and uses thereof |
| GB201621806D0 (en) | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| US10517238B2 (en) | 2017-09-18 | 2019-12-31 | Deere & Company | Implement optimization by automated adjustments |
| WO2020249757A1 (en) | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| EP4389146A3 (en) | 2020-05-22 | 2024-10-02 | Philogen S.p.A. | Tnf-a immunoconjugate therapy for the treatment of brain tumors |
| CN111808161A (zh) * | 2020-06-01 | 2020-10-23 | 北京大学 | 一种对生物化合物进行放射性标记的方法 |
| EP4440599A1 (en) | 2022-01-04 | 2024-10-09 | Philogen S.p.A. | Combination of an immunocytokine comprising il-12 and a kinase inhibitor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| PT1719528E (pt) | 2000-02-24 | 2012-01-06 | Philogen Spa | Composições e métodos para tratamento de angiogénese em lesões patológicas |
| AU2001242432B2 (en) * | 2000-02-24 | 2007-11-08 | Eidgenossische Technische Hochschule Zurich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| WO2001096599A2 (en) * | 2000-06-15 | 2001-12-20 | Philogen S.R.L. | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| BR0306715A (pt) * | 2002-01-03 | 2004-12-28 | Schering Ag | Métodos para diagnóstico e tratamento de tumores |
| CN100535013C (zh) * | 2002-03-11 | 2009-09-02 | 菲洛根股份公司 | 应用抗体分子对肿瘤血管进行选择性定向 |
-
2003
- 2003-09-10 EP EP03255633A patent/EP1514561A1/en not_active Withdrawn
-
2004
- 2004-09-01 SG SG201003976-6A patent/SG162760A1/en unknown
- 2004-09-01 AT AT04764695T patent/ATE499949T1/de active
- 2004-09-01 ES ES04764695T patent/ES2361743T3/es not_active Expired - Lifetime
- 2004-09-01 PT PT04764695T patent/PT1663320E/pt unknown
- 2004-09-01 CN CNB2004800260484A patent/CN100482285C/zh not_active Expired - Fee Related
- 2004-09-01 ME MEP-131/08A patent/MEP13108A/xx unknown
- 2004-09-01 DE DE602004031635T patent/DE602004031635D1/de not_active Expired - Lifetime
- 2004-09-01 JP JP2006525703A patent/JP2007505065A/ja active Pending
- 2004-09-01 PL PL04764695T patent/PL1663320T3/pl unknown
- 2004-09-01 EP EP04764695A patent/EP1663320B1/en not_active Expired - Lifetime
- 2004-09-01 AU AU2004269897A patent/AU2004269897B2/en not_active Ceased
- 2004-09-01 BR BRPI0414272-1A patent/BRPI0414272A/pt not_active IP Right Cessation
- 2004-09-01 WO PCT/EP2004/009733 patent/WO2005023318A1/en active Application Filing
- 2004-09-01 UA UAA200603803A patent/UA89759C2/ru unknown
- 2004-09-01 DK DK04764695.5T patent/DK1663320T3/da active
- 2004-09-01 NZ NZ545640A patent/NZ545640A/xx unknown
- 2004-09-01 EA EA200600494A patent/EA010653B1/ru not_active IP Right Cessation
- 2004-09-01 EP EP10008347A patent/EP2246070A2/en not_active Withdrawn
- 2004-09-01 RS YUP-2006/0176A patent/RS20060176A/sr unknown
- 2004-09-01 KR KR1020067004816A patent/KR101129161B1/ko not_active IP Right Cessation
- 2004-09-01 SI SI200431651T patent/SI1663320T1/sl unknown
- 2004-09-01 CA CA2536256A patent/CA2536256C/en not_active Expired - Fee Related
- 2004-09-10 US US10/937,882 patent/US20050074401A1/en not_active Abandoned
-
2006
- 2006-02-06 IL IL173560A patent/IL173560A0/en unknown
- 2006-03-09 ZA ZA200602014A patent/ZA200602014B/en unknown
- 2006-04-06 CR CR8331A patent/CR8331A/es unknown
- 2006-04-10 NO NO20061619A patent/NO20061619L/no not_active Application Discontinuation
- 2006-04-10 EC EC2006006499A patent/ECSP066499A/es unknown
- 2006-11-30 HK HK06113130.8A patent/HK1092375A1/xx not_active IP Right Cessation
-
2009
- 2009-01-08 US US12/350,346 patent/US20090214423A1/en not_active Abandoned
-
2010
- 2010-01-22 AU AU2010200271A patent/AU2010200271A1/en not_active Abandoned
-
2011
- 2011-03-24 CR CR20110168A patent/CR20110168A/es not_active Application Discontinuation
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