UA85195C2 - Амидометилзамещенные производные 1-(карбоксиалкил)-циклопентилкарбониламинобензазепин-n-уксусной кислоты, способ их получения, промежуточное соединение и фармацевтическая композиции на их основе - Google Patents

Амидометилзамещенные производные 1-(карбоксиалкил)-циклопентилкарбониламинобензазепин-n-уксусной кислоты, способ их получения, промежуточное соединение и фармацевтическая композиции на их основе

Info

Publication number
UA85195C2
UA85195C2 UAA200604364A UAA200604364A UA85195C2 UA 85195 C2 UA85195 C2 UA 85195C2 UA A200604364 A UAA200604364 A UA A200604364A UA A200604364 A UAA200604364 A UA A200604364A UA 85195 C2 UA85195 C2 UA 85195C2
Authority
UA
Ukraine
Prior art keywords
heading
compounds
cyclopentylcarbonylamino
benzazepine
carboxyalkyl
Prior art date
Application number
UAA200604364A
Other languages
English (en)
Ukrainian (uk)
Inventor
Дагмар Хьольт'є
Іван Фішер
Дітер ЦІГЛЕР
Міхаель Веске
Катрін Міхаеліс
Ясмін Карімі-Неяд
Йозеф Мессінгер
Аксель Паль
Констанце Хьофер
Хріссанті Ікономідоу
Лехослав Турскі
Original Assignee
Солвей Фармас'Ютікалс Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Солвей Фармас'Ютікалс Гмбх filed Critical Солвей Фармас'Ютікалс Гмбх
Publication of UA85195C2 publication Critical patent/UA85195C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

В заявке описаны новые соединения, которые проявляют ингибирующее влияние на нейтральную эндопептидазу (НЭП) и/или растворимую эндопептидазу человека (лРЭП), общей формулы І EMBED ISISServer , І в которой заместители R1, R2, R3 и R4 имеют значения, указанные в описании, а также лекарственные средства, которые содержат эти соединения, в частности лекарственные средства, пригодные для лечения или предупреждения сердечно-сосудистых заболеваний, половой дисфункции и/или патологических состояний, связанных с апоптозом.
UAA200604364A 2003-09-26 2004-09-23 Амидометилзамещенные производные 1-(карбоксиалкил)-циклопентилкарбониламинобензазепин-n-уксусной кислоты, способ их получения, промежуточное соединение и фармацевтическая композиции на их основе UA85195C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10344848A DE10344848A1 (de) 2003-09-26 2003-09-26 Amidomethyl-substituierte l-(Carboxyalkyl)-cyclopentylcarbonylamino-benzazepin-N-essigsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enhaltende Arzneimittel

Publications (1)

Publication Number Publication Date
UA85195C2 true UA85195C2 (ru) 2009-01-12

Family

ID=34306115

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200604364A UA85195C2 (ru) 2003-09-26 2004-09-23 Амидометилзамещенные производные 1-(карбоксиалкил)-циклопентилкарбониламинобензазепин-n-уксусной кислоты, способ их получения, промежуточное соединение и фармацевтическая композиции на их основе

Country Status (4)

Country Link
CN (1) CN100497372C (ru)
DE (1) DE10344848A1 (ru)
UA (1) UA85195C2 (ru)
ZA (1) ZA200601081B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007054975A1 (en) * 2005-11-08 2007-05-18 Panacea Biotec Ltd Pharmaceutical compositions for the treatment of cardiovascular and other associated disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction

Also Published As

Publication number Publication date
CN100497372C (zh) 2009-06-10
DE10344848A1 (de) 2005-04-14
ZA200601081B (en) 2007-04-25
CN1856501A (zh) 2006-11-01

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