UA82227C2 - 7-азаиндолы и их применение в качестве терапевтических средств, способ их получения, лекарственное средство на их основе - Google Patents
7-азаиндолы и их применение в качестве терапевтических средств, способ их получения, лекарственное средство на их основе Download PDFInfo
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- UA82227C2 UA82227C2 UAA200509797A UA2005009797A UA82227C2 UA 82227 C2 UA82227 C2 UA 82227C2 UA A200509797 A UAA200509797 A UA A200509797A UA 2005009797 A UA2005009797 A UA 2005009797A UA 82227 C2 UA82227 C2 UA 82227C2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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Abstract
Это изобретение касается замещенных 7-азаиндолов формулы (1), способа их получения, фармацевтических препаратов, содержащих эти соединения, а также фармацевтического применения этих соединений, которые являются ингибиторами фосфодиэстэразы-4, как активных веществ для лечения заболеваний, на которые можно влиять путем ингибирования соединениями, указанными в изобретении, активности фосфодиэстэразы-4, в частности, в иммунокомпетентных клетках (например, в макрофагах и лимфоцитах).(1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10318610A DE10318610A1 (de) | 2003-04-24 | 2003-04-24 | 7-Azaindole und deren Verwendung als Therapeutika |
| PCT/EP2004/004339 WO2004094416A1 (de) | 2003-04-24 | 2004-04-23 | 7-azaindole und deren verwendung als therapeutika |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82227C2 true UA82227C2 (ru) | 2008-03-25 |
Family
ID=33154392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200509797A UA82227C2 (ru) | 2003-04-24 | 2004-04-23 | 7-азаиндолы и их применение в качестве терапевтических средств, способ их получения, лекарственное средство на их основе |
Country Status (18)
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|---|---|
| US (2) | US7211583B2 (ru) |
| EP (1) | EP1613627A1 (ru) |
| JP (1) | JP2006524209A (ru) |
| KR (1) | KR20060021830A (ru) |
| CN (1) | CN100475814C (ru) |
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| BR (1) | BRPI0409790A (ru) |
| CA (1) | CA2523063C (ru) |
| DE (1) | DE10318610A1 (ru) |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE10318610A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
| EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| WO2009147476A1 (en) * | 2008-06-02 | 2009-12-10 | Matrix Laboratories Ltd. | Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation |
| ES2478289T3 (es) * | 2008-09-22 | 2014-07-21 | Isis Innovation Ltd | Bisfosfonatos de 5-azaindol |
| WO2012072727A1 (en) * | 2010-12-03 | 2012-06-07 | Biotie Therapies Gmbh | Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4 |
| SI3762368T1 (sl) | 2018-03-08 | 2022-06-30 | Incyte Corporation | Aminopirazin diolne spojine kot zaviralci PI3K-y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN115057856B (zh) * | 2022-06-08 | 2024-04-02 | 澳门科技大学 | 3,5-二取代-7氮杂吲哚衍生物及其合成方法与应用 |
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| SI0706513T1 (en) * | 1993-07-02 | 2002-10-31 | Altana Pharma Ag | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| GB9420521D0 (en) | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
| AP2001002304A0 (en) | 1996-05-03 | 2001-12-31 | Pfizer | Substituted indazole derivatives and related compounds |
| DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
| WO1999050262A1 (en) * | 1998-04-01 | 1999-10-07 | Janssen Pharmaceutica N.V. | Pde iv inhibiting pyridine derivatives |
| DE19818964A1 (de) | 1998-04-28 | 1999-11-04 | Dresden Arzneimittel | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung |
| JP3842043B2 (ja) | 1998-04-28 | 2006-11-08 | エルビオン アクチエンゲゼルシャフト | 新規ヒドロキシインドール、ホスホジエステラーゼ４のインヒビタとしてのその使用及びその製法 |
| TW555759B (en) * | 1998-06-08 | 2003-10-01 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| GB9824160D0 (en) * | 1998-11-04 | 1998-12-30 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| US6476034B2 (en) * | 2000-02-22 | 2002-11-05 | Bristol-Myers Squibb Company | Antiviral azaindole derivatives |
| CA2407780A1 (en) * | 2000-05-25 | 2001-11-29 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
| TWI262920B (en) * | 2000-10-27 | 2006-10-01 | Elbion Ag | New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them |
| DE10318610A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
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| RU2005136434A (ru) | 2006-03-27 |
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| US20070161671A1 (en) | 2007-07-12 |
| CN1805960A (zh) | 2006-07-19 |
| AR044080A1 (es) | 2005-08-24 |
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| NO20055515D0 (no) | 2005-11-22 |
| BRPI0409790A (pt) | 2006-05-30 |
| CA2523063C (en) | 2011-12-06 |
| DE10318610A1 (de) | 2004-11-11 |
| AU2004232483A1 (en) | 2004-11-04 |
| CN100475814C (zh) | 2009-04-08 |
| NO20055515L (no) | 2006-01-24 |
| JP2006524209A (ja) | 2006-10-26 |
| EP1613627A1 (de) | 2006-01-11 |
| US20040224971A1 (en) | 2004-11-11 |
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