UA81382C2 - Composition for treating retinol-related diseases by modulation of retinol binding - Google Patents
Composition for treating retinol-related diseases by modulation of retinol binding Download PDFInfo
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- UA81382C2 UA81382C2 UAA200704499A UAA200704499A UA81382C2 UA 81382 C2 UA81382 C2 UA 81382C2 UA A200704499 A UAA200704499 A UA A200704499A UA A200704499 A UAA200704499 A UA A200704499A UA 81382 C2 UA81382 C2 UA 81382C2
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- retinol
- mammal
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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ZA (1) | ZA200800844B (xx) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2277516A1 (en) * | 2004-06-23 | 2011-01-26 | ReVision Therapeutics, Inc. | Retinyl derivatives for treating ophtalmic conditions |
CA2584396A1 (en) * | 2004-11-04 | 2006-05-18 | Sirion Therapeutics, Inc. | Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation |
CN101072555B (zh) * | 2004-12-08 | 2011-06-29 | 矫正诊疗公司 | 治疗与视黄醇有关的疾病的方法、分析和组合物 |
ES2449150T3 (es) | 2007-09-12 | 2014-03-18 | The Trustees Of Columbia University In The City Of New York | Compuestos y métodos para tratar la degeneración muscular |
CN101229147B (zh) * | 2007-12-24 | 2010-09-01 | 复旦大学 | N-4-羟苯视黄酰胺在制备抗肝纤维化药物中的用途 |
US20110210074A1 (en) * | 2008-06-26 | 2011-09-01 | Winchester James F | Removal of myoglobin from blood and/or physiological fluids |
EP2642998B1 (en) * | 2010-11-24 | 2020-09-16 | The Trustees of Columbia University in the City of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
WO2012078525A2 (en) * | 2010-12-06 | 2012-06-14 | Revision Therapeutics, Inc. | Compositions and methods for treating ophthalmic conditions |
WO2013166041A1 (en) * | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular |
US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
WO2014151959A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
ES2700541T3 (es) | 2013-03-14 | 2019-02-18 | Univ Columbia | Octahidrociclopentapirroles, su preparación y uso |
US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
ES2705247T3 (es) | 2013-03-14 | 2019-03-22 | Univ Columbia | 4-fenilpiperidinas, su preparación y uso |
US10092393B2 (en) | 2013-03-14 | 2018-10-09 | Allotex, Inc. | Corneal implant systems and methods |
ES2896173T3 (es) | 2014-02-13 | 2022-02-24 | Katairo Gmbh | Procedimientos para la determinación de compuestos o composiciones para el tratamiento de enfermedades relacionadas con la lipofuscina y compuestos o composiciones |
EP4036094A1 (en) | 2014-04-30 | 2022-08-03 | The Trustees of Columbia University in the City of New York | Substituted 4-phenylpiperidines, their preparation and use |
US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
GB201706009D0 (en) * | 2017-04-13 | 2017-05-31 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of stargardt disease |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
US4190594A (en) * | 1975-11-03 | 1980-02-26 | Johnson & Johnson | Retinoic acid derivatives |
US4323581A (en) * | 1978-07-31 | 1982-04-06 | Johnson & Johnson | Method of treating carcinogenesis |
US4665098A (en) * | 1985-03-28 | 1987-05-12 | Mcneilab, Inc. | Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide having increased bioavailability |
US4874795A (en) * | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4743400A (en) * | 1986-09-22 | 1988-05-10 | Mcneilab, Inc. | Process for preparing retinoyl chlorides |
US5814612A (en) * | 1991-04-09 | 1998-09-29 | Sloan-Kettering Institute For Cancer Research | Retinol derivatives and uses thereof |
US6506917B1 (en) * | 1991-12-18 | 2003-01-14 | The Salk Institute For Biological Studies | Compounds and compositions useful for modulation of processes mediated by RXR |
US6093706A (en) * | 1992-03-04 | 2000-07-25 | Bioresponse, L.L.C. | Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders |
US5314909A (en) * | 1993-03-17 | 1994-05-24 | Merck & Co., Inc. | Use of non-steroidal antiiflammatory agents in macular degeneration |
US5399757A (en) * | 1993-07-20 | 1995-03-21 | Ortho Pharmaceutical Corporation | Process for the preparation of N-(4-hydroxyphenyl)-retinamide |
US5427571A (en) * | 1994-08-08 | 1995-06-27 | Cor-A-Vent Incorporated | Ventilated cap system for the ridge of a roof |
US5824685A (en) * | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
US5596011A (en) * | 1995-04-06 | 1997-01-21 | Repine; Karen M. | Method for the treatment of macular degeneration |
US5846220A (en) * | 1996-04-30 | 1998-12-08 | Medtronic, Inc. | Therapeutic method for treatment of Alzheimer's disease |
US6034211A (en) * | 1996-06-03 | 2000-03-07 | Kelly; Jeffery W. | β-sheet nucleating peptidomimetics |
US5955305A (en) * | 1997-04-28 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | Human retinoid binding protein |
US5776915A (en) * | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
CA2301032C (en) * | 1997-08-15 | 2009-01-13 | Duke University | A method of preventing or treating estrogen-dependent diseases and disorders |
WO1999058126A1 (en) * | 1998-05-11 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
EP1153248B1 (en) * | 1998-12-17 | 2006-04-19 | Diversi-Plast Products Inc. | Ridge cap vent |
US6128870A (en) * | 1999-05-24 | 2000-10-10 | Kohler; Raymond L. | Roof vent system |
US7229961B2 (en) * | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
US6450882B1 (en) * | 2000-08-30 | 2002-09-17 | Liberty Diversified Industries, Inc. | Precipitation resistant ridge vent |
US20020031539A1 (en) * | 2000-08-30 | 2002-03-14 | The Brigham And Women's Hospital, Inc. | Oxidized forms of retinoic acid as ligands for peroxisome proliferator activated receptor gamma |
WO2002032413A2 (en) * | 2000-10-17 | 2002-04-25 | Board Of Regents, The University Of Texas System | A method to incorporate n-(4-hydroxyphenyl) retinamide in liposomes |
DE60136648D1 (de) * | 2000-12-05 | 2009-01-02 | Los Angeles Childrens Hospital | Pharmazeutische zusammensetzungen von fenretinid mit erhöhter bioverfügbarkeit und verfahren zu deren verwendung |
US20030032078A1 (en) * | 2001-01-23 | 2003-02-13 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of macular and retinal degenerations |
AU2002345563A1 (en) * | 2001-06-15 | 2003-01-02 | The Cleveland Clinic Foundation | Radiometric quantitation of elicited eye autofluorescence |
AU2002346053B2 (en) * | 2001-06-22 | 2008-03-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6696606B2 (en) * | 2001-07-06 | 2004-02-24 | The Ohio State University Research Foundation | Solid phase synthesis of arylretinamides |
US6599891B2 (en) * | 2001-07-20 | 2003-07-29 | Qlt Inc. | Treatment of macular edema |
US7595430B2 (en) * | 2002-10-30 | 2009-09-29 | University Of Kentucky Research Foundation | Methods and animal model for analyzing age-related macular degeneration |
US7354574B2 (en) * | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
MXPA06008780A (es) * | 2004-02-17 | 2007-02-16 | Harvard College | Manejo de alteraciones oftalmologicas, incluida la degeneracion macular. |
US7566808B2 (en) * | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
EP2277516A1 (en) * | 2004-06-23 | 2011-01-26 | ReVision Therapeutics, Inc. | Retinyl derivatives for treating ophtalmic conditions |
CA2575265A1 (en) * | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat ophthalmic disorders |
CA2584396A1 (en) * | 2004-11-04 | 2006-05-18 | Sirion Therapeutics, Inc. | Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation |
CN101072555B (zh) * | 2004-12-08 | 2011-06-29 | 矫正诊疗公司 | 治疗与视黄醇有关的疾病的方法、分析和组合物 |
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WO2007008821A3 (en) | 2007-07-12 |
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CA2614627C (en) | 2013-11-19 |
AU2006268374A8 (en) | 2008-03-20 |
EP1904043A2 (en) | 2008-04-02 |
ZA200800844B (en) | 2009-04-29 |
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CN101252924A (zh) | 2008-08-27 |
TW200727894A (en) | 2007-08-01 |
AR055075A1 (es) | 2007-08-01 |
US20120288568A1 (en) | 2012-11-15 |
GB2428975A (en) | 2007-02-14 |
CN101252924B (zh) | 2013-06-19 |
GB0613730D0 (en) | 2006-08-23 |
BRPI0612405A2 (pt) | 2012-04-24 |
EA200800291A1 (ru) | 2008-06-30 |
EP1904043A4 (en) | 2008-09-17 |
AU2006268374A2 (en) | 2008-05-22 |
AU2006268374A1 (en) | 2007-01-18 |
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