UA74419C2 - SUBSTITUTED PYRIDINES AND USE THEREOF AS ANTAGONISTS AT metabotropic glutamate receptors - Google Patents

SUBSTITUTED PYRIDINES AND USE THEREOF AS ANTAGONISTS AT metabotropic glutamate receptors

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Publication number
UA74419C2
UA74419C2 UA2003088019A UA200388019A UA74419C2 UA 74419 C2 UA74419 C2 UA 74419C2 UA 2003088019 A UA2003088019 A UA 2003088019A UA 200388019 A UA200388019 A UA 200388019A UA 74419 C2 UA74419 C2 UA 74419C2
Authority
UA
Ukraine
Prior art keywords
antagonists
metabotropic glutamate
glutamate receptors
substituted pyridines
compounds
Prior art date
Application number
UA2003088019A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Абделмалік Слессі
Абделмалик Слесси
ВАГЕНЕН Бредфорд ВАН
Томас М. Сторманн
Скотт Т. Моу
Сузан М. Шіхен
Дональд А. Макліод
Дональд А. Маклиод
Деріл Л. Сміт
Метвін Бенджамін Айзек
Original Assignee
Ен Пі Ес Фармасьютікалс, Інк.
Эн Пи Эс Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23028892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA74419(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ен Пі Ес Фармасьютікалс, Інк., Эн Пи Эс Фармасьютикалс, Инк. filed Critical Ен Пі Ес Фармасьютікалс, Інк.
Publication of UA74419C2 publication Critical patent/UA74419C2/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Method of preparing the compounds also are disclosed.
UA2003088019A 2001-02-21 2002-02-19 SUBSTITUTED PYRIDINES AND USE THEREOF AS ANTAGONISTS AT metabotropic glutamate receptors UA74419C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26984701P 2001-02-21 2001-02-21
PCT/US2002/004689 WO2002068417A2 (en) 2001-02-21 2002-02-19 Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

Publications (1)

Publication Number Publication Date
UA74419C2 true UA74419C2 (en) 2005-12-15

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ID=23028892

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UA2003088019A UA74419C2 (en) 2001-02-21 2002-02-19 SUBSTITUTED PYRIDINES AND USE THEREOF AS ANTAGONISTS AT metabotropic glutamate receptors

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EP (2) EP1379525B1 (en)
JP (2) JP4519404B2 (en)
KR (1) KR100838447B1 (en)
CN (2) CN1332959C (en)
AT (1) ATE375340T1 (en)
AU (1) AU2002306517B2 (en)
BR (1) BR0207390A (en)
CA (1) CA2438991C (en)
CY (1) CY1107005T1 (en)
DE (1) DE60222872T2 (en)
DK (1) DK1379525T3 (en)
ES (1) ES2292830T3 (en)
HK (1) HK1060559A1 (en)
IL (1) IL157491A0 (en)
IS (1) IS2564B (en)
MX (1) MXPA03007513A (en)
NO (1) NO326105B1 (en)
NZ (1) NZ527691A (en)
PL (1) PL369598A1 (en)
PT (1) PT1379525E (en)
RU (1) RU2319701C2 (en)
SI (1) SI1379525T1 (en)
UA (1) UA74419C2 (en)
WO (1) WO2002068417A2 (en)
ZA (1) ZA200306493B (en)

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