UA7018A1 - METHOD OF OBTAINING ACRYLIC ACID DERIVATIVES - Google Patents

METHOD OF OBTAINING ACRYLIC ACID DERIVATIVES

Info

Publication number
UA7018A1
UA7018A1 UA3950797A UA3950797A UA7018A1 UA 7018 A1 UA7018 A1 UA 7018A1 UA 3950797 A UA3950797 A UA 3950797A UA 3950797 A UA3950797 A UA 3950797A UA 7018 A1 UA7018 A1 UA 7018A1
Authority
UA
Ukraine
Prior art keywords
acrylic acid
acid derivatives
ethyl
methyl
obtaining acrylic
Prior art date
Application number
UA3950797A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Грохе Клаус
Original Assignee
"Байер АГ"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Байер АГ" filed Critical "Байер АГ"
Publication of UA7018A1 publication Critical patent/UA7018A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к способу получения производных акриловой кислоты (АК) формулы где R1 – СN, - CООR4, где R4 - метил или этил; R2 и R3 – одинаковы и означают метил или этил; X и X' - F, Сl; X' - Н, F, которые являются полупродуктом для синтеза ципрофлоксацина. Получение целевых соединений ведут из галоидангидрида и производного амина при температуре от комнатной до температуры кипения реакционной смеси в среде безводного органического растворителя в присутствии акцептора кислоты - третичного амина. Способ обеспечивает повышение выхода до 70-79% (против 62%).The invention relates to a method for producing acrylic acid (AA) derivatives of the formula where R1 is CN, is COOR4, where R4 is methyl or ethyl; R2 and R3 are the same and are methyl or ethyl; X and X 'are F, Cl; X '- H, F, which are an intermediate for the synthesis of ciprofloxacin. Obtaining the target compounds is carried out from an acid halide and an amine derivative at a temperature from room temperature to the boiling point of the reaction mixture in an anhydrous organic solvent in the presence of an acid acceptor, a tertiary amine. The method provides an increase in yield up to 70-79% (versus 62%).

UA3950797A 1984-09-29 1985-09-09 METHOD OF OBTAINING ACRYLIC ACID DERIVATIVES UA7018A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3435930 1984-09-29

Publications (1)

Publication Number Publication Date
UA7018A1 true UA7018A1 (en) 1995-03-31

Family

ID=6246777

Family Applications (1)

Application Number Title Priority Date Filing Date
UA3950797A UA7018A1 (en) 1984-09-29 1985-09-09 METHOD OF OBTAINING ACRYLIC ACID DERIVATIVES

Country Status (4)

Country Link
JP (1) JPS61112051A (en)
DD (1) DD240543A5 (en)
SU (1) SU1395139A3 (en)
UA (1) UA7018A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3724466A1 (en) * 1987-07-24 1989-02-02 Bayer Ag PROCESS FOR THE PREPARATION OF CHINOLON CARBOXYANESE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243406A (en) * 1978-12-26 1981-01-06 Monsanto Company 5-Aryl-4-isoxazolecarboxylate-safening agents
JPS61100568A (en) * 1984-10-19 1986-05-19 Otsuka Pharmaceut Co Ltd Benzohetero-ring compound

Also Published As

Publication number Publication date
SU1395139A3 (en) 1988-05-07
JPS61112051A (en) 1986-05-30
JPH0457662B2 (en) 1992-09-14
DD240543A5 (en) 1986-11-05

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