UA7018A1 - METHOD OF OBTAINING ACRYLIC ACID DERIVATIVES - Google Patents
METHOD OF OBTAINING ACRYLIC ACID DERIVATIVESInfo
- Publication number
- UA7018A1 UA7018A1 UA3950797A UA3950797A UA7018A1 UA 7018 A1 UA7018 A1 UA 7018A1 UA 3950797 A UA3950797 A UA 3950797A UA 3950797 A UA3950797 A UA 3950797A UA 7018 A1 UA7018 A1 UA 7018A1
- Authority
- UA
- Ukraine
- Prior art keywords
- acrylic acid
- acid derivatives
- ethyl
- methyl
- obtaining acrylic
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к способу получения производных акриловой кислоты (АК) формулы где R1 – СN, - CООR4, где R4 - метил или этил; R2 и R3 – одинаковы и означают метил или этил; X и X' - F, Сl; X' - Н, F, которые являются полупродуктом для синтеза ципрофлоксацина. Получение целевых соединений ведут из галоидангидрида и производного амина при температуре от комнатной до температуры кипения реакционной смеси в среде безводного органического растворителя в присутствии акцептора кислоты - третичного амина. Способ обеспечивает повышение выхода до 70-79% (против 62%).The invention relates to a method for producing acrylic acid (AA) derivatives of the formula where R1 is CN, is COOR4, where R4 is methyl or ethyl; R2 and R3 are the same and are methyl or ethyl; X and X 'are F, Cl; X '- H, F, which are an intermediate for the synthesis of ciprofloxacin. Obtaining the target compounds is carried out from an acid halide and an amine derivative at a temperature from room temperature to the boiling point of the reaction mixture in an anhydrous organic solvent in the presence of an acid acceptor, a tertiary amine. The method provides an increase in yield up to 70-79% (versus 62%).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3435930 | 1984-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA7018A1 true UA7018A1 (en) | 1995-03-31 |
Family
ID=6246777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA3950797A UA7018A1 (en) | 1984-09-29 | 1985-09-09 | METHOD OF OBTAINING ACRYLIC ACID DERIVATIVES |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS61112051A (en) |
DD (1) | DD240543A5 (en) |
SU (1) | SU1395139A3 (en) |
UA (1) | UA7018A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3724466A1 (en) * | 1987-07-24 | 1989-02-02 | Bayer Ag | PROCESS FOR THE PREPARATION OF CHINOLON CARBOXYANESE |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4243406A (en) * | 1978-12-26 | 1981-01-06 | Monsanto Company | 5-Aryl-4-isoxazolecarboxylate-safening agents |
JPS61100568A (en) * | 1984-10-19 | 1986-05-19 | Otsuka Pharmaceut Co Ltd | Benzohetero-ring compound |
-
1985
- 1985-09-09 SU SU853950797A patent/SU1395139A3/en active
- 1985-09-09 UA UA3950797A patent/UA7018A1/en unknown
- 1985-09-25 JP JP60210345A patent/JPS61112051A/en active Granted
- 1985-09-27 DD DD85281131A patent/DD240543A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SU1395139A3 (en) | 1988-05-07 |
JPS61112051A (en) | 1986-05-30 |
JPH0457662B2 (en) | 1992-09-14 |
DD240543A5 (en) | 1986-11-05 |
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