UA66840C2 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Info

Publication number
UA66840C2
UA66840C2 UA2000095501A UA00095501A UA66840C2 UA 66840 C2 UA66840 C2 UA 66840C2 UA 2000095501 A UA2000095501 A UA 2000095501A UA 00095501 A UA00095501 A UA 00095501A UA 66840 C2 UA66840 C2 UA 66840C2
Authority
UA
Ukraine
Prior art keywords
formula
inhibiting
admixture
association
pharmaceutically acceptable
Prior art date
Application number
UA2000095501A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Дженніфєр А. Дюмон
Алан Дж. Бітонті
Алан Дж. Битонти
Девід Р. Борчердінг
Нортон П. Піт
Х. Ренделл Мансон
Патрік В.К. Шам
Original Assignee
Авентіс Фармасьютікалз Інк.
Авентис Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентіс Фармасьютікалз Інк., Авентис Фармасьютикалз Инк. filed Critical Авентіс Фармасьютікалз Інк.
Priority claimed from PCT/US1999/003450 external-priority patent/WO1999043675A1/en
Publication of UA66840C2 publication Critical patent/UA66840C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of Formula (I) wherein R is selected from the group consisting of R2, R2NH-, or R3R4N-R5-, and R1 is selected from the group consisting of cyclopentyl, cyclopentenyl and isopropyl, and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof. The invention provides a method of inhibiting cell cycle progression, a method of inhibiting cyclin dependent kinases, particularly cdk-2, a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms, a composition comprising an assayable amount of a compound of Formula (I) in admixture or otherwise in association with an inert carrier, and a pharmaceutical composition comprising an effective inhibitory amount of a compound of Formula (I) in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients. (І)
UA2000095501A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines UA66840C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3097598A 1998-02-26 1998-02-26
PCT/US1999/003450 WO1999043675A1 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
UA66840C2 true UA66840C2 (en) 2004-06-15

Family

ID=21856977

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000095501A UA66840C2 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Country Status (14)

Country Link
KR (1) KR100568657B1 (en)
AR (1) AR018121A1 (en)
AT (1) ATE252583T1 (en)
DE (1) DE69912248T2 (en)
DK (1) DK1056744T3 (en)
ES (1) ES2207182T3 (en)
HK (1) HK1030949A1 (en)
ID (1) ID25444A (en)
NZ (1) NZ506235A (en)
OA (1) OA11455A (en)
PT (1) PT1056744E (en)
RU (1) RU2200162C2 (en)
TW (1) TWI225060B (en)
UA (1) UA66840C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091346B1 (en) * 1995-11-01 2006-08-15 Novartis Ag Purine derivatives and processes for their preparation
FR2741881B1 (en) * 1995-12-01 1999-07-30 Centre Nat Rech Scient NOVEL PURINE DERIVATIVES HAVING IN PARTICULAR ANTI-PROLIFERATIVE PRORIETES AND THEIR BIOLOGICAL APPLICATIONS

Also Published As

Publication number Publication date
KR20010041318A (en) 2001-05-15
ATE252583T1 (en) 2003-11-15
RU2200162C2 (en) 2003-03-10
KR100568657B1 (en) 2006-04-07
PT1056744E (en) 2004-03-31
TWI225060B (en) 2004-12-11
NZ506235A (en) 2003-02-28
DE69912248T2 (en) 2004-04-22
ID25444A (en) 2000-10-05
ES2207182T3 (en) 2004-05-16
OA11455A (en) 2003-12-05
DK1056744T3 (en) 2004-02-23
HK1030949A1 (en) 2001-05-25
DE69912248D1 (en) 2003-11-27
AR018121A1 (en) 2001-10-31

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