NZ506235A - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Info

Publication number
NZ506235A
NZ506235A NZ506235A NZ50623599A NZ506235A NZ 506235 A NZ506235 A NZ 506235A NZ 506235 A NZ506235 A NZ 506235A NZ 50623599 A NZ50623599 A NZ 50623599A NZ 506235 A NZ506235 A NZ 506235A
Authority
NZ
New Zealand
Prior art keywords
formula
inhibiting
admixture
association
pharmaceutically acceptable
Prior art date
Application number
NZ506235A
Inventor
Jennifer A Dumont
Alan J Bitonti
David R Borcherding
Norton P Peet
H Randall Munson
Patrick W K Shum
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Priority claimed from PCT/US1999/003450 external-priority patent/WO1999043675A1/en
Publication of NZ506235A publication Critical patent/NZ506235A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of Formula (I) wherein R is selected from the group consisting of R2, R2NH-, or R3R4N-R5-, and R1 is selected from the group consisting of cyclopentyl, cyclopentenyl and isopropyl, and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof. A method of inhibiting cell cycle progression, a method of inhibiting cyclin dependent kinases, particularly cdk-2, a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms, a composition comprising an assayable amount of a compound of Formula (I) in admixture or otherwise in association with an inert carrier, and a pharmaceutical composition comprising an effective inhibitory amount of a compound of Formula (I) in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
NZ506235A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines NZ506235A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3097598A 1998-02-26 1998-02-26
PCT/US1999/003450 WO1999043675A1 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
NZ506235A true NZ506235A (en) 2003-02-28

Family

ID=21856977

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ506235A NZ506235A (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Country Status (14)

Country Link
KR (1) KR100568657B1 (en)
AR (1) AR018121A1 (en)
AT (1) ATE252583T1 (en)
DE (1) DE69912248T2 (en)
DK (1) DK1056744T3 (en)
ES (1) ES2207182T3 (en)
HK (1) HK1030949A1 (en)
ID (1) ID25444A (en)
NZ (1) NZ506235A (en)
OA (1) OA11455A (en)
PT (1) PT1056744E (en)
RU (1) RU2200162C2 (en)
TW (1) TWI225060B (en)
UA (1) UA66840C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2234609C (en) * 1995-11-01 2006-11-28 Novartis Ag 2-amino-6-anilino-purine derivatives and processes for their preparation
FR2741881B1 (en) * 1995-12-01 1999-07-30 Centre Nat Rech Scient NOVEL PURINE DERIVATIVES HAVING IN PARTICULAR ANTI-PROLIFERATIVE PRORIETES AND THEIR BIOLOGICAL APPLICATIONS

Also Published As

Publication number Publication date
DE69912248T2 (en) 2004-04-22
DE69912248D1 (en) 2003-11-27
ID25444A (en) 2000-10-05
RU2200162C2 (en) 2003-03-10
DK1056744T3 (en) 2004-02-23
AR018121A1 (en) 2001-10-31
OA11455A (en) 2003-12-05
TWI225060B (en) 2004-12-11
ES2207182T3 (en) 2004-05-16
KR100568657B1 (en) 2006-04-07
PT1056744E (en) 2004-03-31
UA66840C2 (en) 2004-06-15
KR20010041318A (en) 2001-05-15
ATE252583T1 (en) 2003-11-15
HK1030949A1 (en) 2001-05-25

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Legal Events

Date Code Title Description
PSEA Patent sealed
S35A Application for proceedings under section 35 (restoration of lapsed patents)
RENW Renewal (renewal fees accepted)
S35R Proceedings under section 35 (restoration of lapsed patents): patent restored