UA18249A - Спосіб одержаhhя кристалів дигідрата гідрохлориду оhдаhсетроhа змеhшеhого розміру - Google Patents

Спосіб одержаhhя кристалів дигідрата гідрохлориду оhдаhсетроhа змеhшеhого розміру

Info

Publication number
UA18249A
UA18249A UA4830462A UA4830462A UA18249A UA 18249 A UA18249 A UA 18249A UA 4830462 A UA4830462 A UA 4830462A UA 4830462 A UA4830462 A UA 4830462A UA 18249 A UA18249 A UA 18249A
Authority
UA
Ukraine
Prior art keywords
dihydrate
ondansetron hydrochloride
preparation
less
reduced size
Prior art date
Application number
UA4830462A
Other languages
English (en)
Russian (ru)
Inventor
Тревор Коллін Девід
Original Assignee
Глексо Груп Лімітед
Глексо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10659180&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA18249(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глексо Груп Лімітед, Глексо Груп Лимитед filed Critical Глексо Груп Лімітед
Publication of UA18249A publication Critical patent/UA18249A/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Otolaryngology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)

Abstract

Спосіб одержання кристалів дигідрату гідрохлориду ондансетрону зменшеного розміру, одержаного шляхом кристалізації з суміші водних розчинників. Дигідрат гідрохлориду ондансетрону десольвують за допомогою сушіння при температурі не нижче 40 °C і при атмосферному або зниженому тиску, рівному 200 мм рт.ст, або менше. Потім регідратують з отриманням кристалічного дигідрату гідрохлориду ондансетрону, в якому 100 мас.% кристалів мають розмір менше ніж 250 мкм і не менше 80 мас.% кристалів мають розмір менш ніж 63 мкм.
UA4830462A 1989-06-28 1990-06-27 Спосіб одержаhhя кристалів дигідрата гідрохлориду оhдаhсетроhа змеhшеhого розміру UA18249A (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898914804A GB8914804D0 (en) 1989-06-28 1989-06-28 Process

Publications (1)

Publication Number Publication Date
UA18249A true UA18249A (uk) 1997-12-25

Family

ID=10659180

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4830462A UA18249A (uk) 1989-06-28 1990-06-27 Спосіб одержаhhя кристалів дигідрата гідрохлориду оhдаhсетроhа змеhшеhого розміру

Country Status (20)

Country Link
US (1) US5622720A (uk)
EP (1) EP0415522B1 (uk)
JP (1) JP3093242B2 (uk)
KR (1) KR0182789B1 (uk)
AT (1) ATE110380T1 (uk)
AU (1) AU637110B2 (uk)
CA (1) CA2019944C (uk)
DE (1) DE69011786T2 (uk)
DK (1) DK0415522T3 (uk)
ES (1) ES2060045T3 (uk)
GB (1) GB8914804D0 (uk)
HK (1) HK44495A (uk)
HU (1) HU208009B (uk)
IE (1) IE64715B1 (uk)
IL (1) IL94888A (uk)
NZ (1) NZ234267A (uk)
RU (1) RU2002745C1 (uk)
SA (1) SA90110025B1 (uk)
UA (1) UA18249A (uk)
ZA (1) ZA905002B (uk)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115707A1 (en) * 2001-01-11 2002-08-22 Rami Lidor-Hadas Process for preparing pure ondansetron hydrochloride dihydrate
MXPA04007995A (es) * 2002-02-19 2004-11-26 Teva Pharma Desolvatacion de solvatos de hemicalcio de atorvastatina.
WO2003082804A1 (en) 2002-03-28 2003-10-09 Synthon B.V. Venlafaxine besylate
US7098345B2 (en) 2002-04-29 2006-08-29 TEVA Gyógyszergyár Zárkörüen Müködö Részvénytársaság Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
US20060083759A1 (en) * 2002-07-17 2006-04-20 Aleksander Resman Stabilization of the profile of release of active substances from a formulation
CA2505990C (en) * 2002-11-15 2009-05-19 Helsinn Healthcare S.A. Palonosetron for the treatment of chemotherapy-induced emesis
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
MY143789A (en) * 2003-02-18 2011-07-15 Helsinn Healthcare Sa Use of palonosetron treating post- operative nausea and vomiting
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20060167072A1 (en) * 2004-01-30 2006-07-27 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
CA2565854A1 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
AU2006216696B2 (en) * 2005-02-23 2011-08-18 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations of improved content uniformity
UA88186C2 (uk) * 2005-02-23 2009-09-25 Тева Фармасьютикл Индастриз, Лтд. Расагілінові формуляції з поліпшеною однорідністю вмісту
UA97653C2 (uk) * 2006-10-24 2012-03-12 Хелсинн Хелткер С.А. М'які капсули, що містять палоносетрону гідрохлорид, які мають поліпшену стабільність і біологічну доступність

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
NL190373C (nl) * 1984-01-25 1994-02-01 Glaxo Group Ltd Een 3-gesubstitueerde aminomethyl-2,3-dihydro-4(1h)-carbazolon, werkwijze ter bereiding daarvan, alsmede een farmaceutisch preparaat.
IE60991B1 (en) * 1986-12-17 1994-09-07 Glaxo Group Ltd Use of ketone derivatives in the treatment of cognitive disorders
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US5344658A (en) * 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron

Also Published As

Publication number Publication date
NZ234267A (en) 1992-11-25
HUT54140A (en) 1991-01-28
IL94888A0 (en) 1991-04-15
KR0182789B1 (ko) 1999-10-15
HU208009B (en) 1993-07-28
HU904015D0 (en) 1990-12-28
ATE110380T1 (de) 1994-09-15
ZA905002B (en) 1991-12-24
DK0415522T3 (da) 1994-09-19
DE69011786T2 (de) 1994-12-15
IE902333A1 (en) 1991-01-16
SA90110025B1 (ar) 2001-03-24
IE64715B1 (en) 1995-08-23
AU5787490A (en) 1991-01-03
ES2060045T3 (es) 1994-11-16
US5622720A (en) 1997-04-22
EP0415522A1 (en) 1991-03-06
KR910000709A (ko) 1991-01-30
IL94888A (en) 1995-03-15
JP3093242B2 (ja) 2000-10-03
RU2002745C1 (ru) 1993-11-15
CA2019944C (en) 2000-05-09
HK44495A (en) 1995-03-31
EP0415522B1 (en) 1994-08-24
GB8914804D0 (en) 1989-08-16
JPH0395178A (ja) 1991-04-19
AU637110B2 (en) 1993-05-20
IE902333L (en) 1990-12-28
CA2019944A1 (en) 1990-12-28
DE69011786D1 (de) 1994-09-29

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