UA146823U - APPLICATION OF INFUSION COMPLEX DRUG SORBILACT POLIFUNCTIONAL ACTION FOR NORMALIZATION OF HEMATOLOGICAL INDICATORS ON OPERALS OPERANS - Google Patents

Abstract

The use of infusion complex drug Sorbilact multifunctional action to normalize the hematological parameters of operated patients with gastric cancer after gastrectomy and to prevent suture divergence in the early postoperative period and the development of functional insufficiency of the esophageal and intestinal anastomosis immediately after surgery injected 800 ml intravenously 10-12 ml per kg of body weight) per day at a rate of 30 drops per minute for 5 days.

Description

the drug is administered in the form of intravenous drip infusions of 800 ml (10-12 ml per kg of body weight) per day at a rate of 30 drops per minute for 5 days.

A useful model belongs to the field of medicine, namely the use of the multi-functional infusion complex drug Sorbilact to normalize the hematological parameters of gastric cancer patients after gastrectomy and to prevent the separation of the sutures of the esophagus and intestine anastomosis in the early postoperative period.

The relevance of the subject of the useful model is connected with the increase in the incidence of stomach cancer and the increase in the number of total gastrectomy operations.

Oncological patients with gastric cancer who underwent gastrectomy develop changes in hematological indicators that worsen the course of the early postoperative period and lead to complications. The reason for the mortality of oncological patients with stomach cancer after gastrectomy is the separation of the sutures of the anastomosis of the esophagus and intestine. Postoperative complications with separation of the anastomotic sutures and functional insufficiency of the esophageal-intestinal anastomosis cannot be treated without correcting the hematological parameters of the operated patients.

The use of the multi-functional infusion complex drug Sorbilact to normalize the hematological parameters of gastric cancer patients after gastrectomy and to prevent the separation of the anastomosis sutures of the esophagus and intestine in the early postoperative period is relevant and necessary in the surgical treatment of oncological patients with gastric cancer.

Ringer-Locke solution for intravenous infusions of 1000.0 ml per day was used as a comparison drug. Composition of Ringer-Lock solution: sodium chloride - 9.0 g, sodium bicarbonate - 0.2 g, calcium chloride - 0.2 g, potassium chloride - 0.2 g, glucose - 1.0 g, water for injections up to 1 liter.

In contrast to the Ringer-Lock solution, in the infusion drug Sorbilact, the main active substances are sorbitol and the alkalizing agent sodium lactate, which normalizes the acid-base state of the body.

Sorbilact is an infusion preparation that includes: sorbitol - 200.0 g, sodium lactate (per 100 95 substance) - 19.0 g, sodium chloride - 6.0 g, calcium chloride - 0.1 g, potassium chloride - 0.3 g, magnesium chloride - 0.2 g, water for injections up to 1.0 liters.

Ionic composition of the drug: sodium ion - 6.395 mg/ml - 278.16 mmol/l; potassium ion - 0.157 mg/ml - 4.02 mmol/l; calcium ion - 0.036 mg/ml - 0.90 mmol/l; magnesium ion - 0.051 mg/ml - 2.10 mmol/l; chlorine ion - 3.995 mg/ml - 112.69 mmol/l; lactate ion - 15.635 mg/ml - 175.52 mmol/l; pH-6.0-7.6.

The calorie content of Sorbilact is 656 kcal (2736 kJ) per 800.0 milliliters of infusion solution. Sorbilact is a clear liquid in bottles of 200.0 and 400.0 ml.

Complex infusion drug Sorbilact of multifunctional action was created and developed at the State Institution "Institute of Blood Pathology and Transfusion Medicine

of the National Academy of Medical Sciences of Ukraine", Lviv.

The instructions for the medical use of the infusion drug Sorbilact were approved by the order of the Ministry of Health of Ukraine, registration certificate Mo OA/2401/01/01 dated October 13, 2014.

The purpose of the useful model is to increase the therapeutic effectiveness of infusion therapy with the use of the complex drug Sorbilact of multifunctional action in oncological patients with gastric cancer after gastrectomy to normalize the hematological indicators of operated patients and to prevent suture separation and the development of functional insufficiency of the anastomosis of the esophagus and intestine in the early postoperative period. reducing the duration of treatment of operated patients, reducing the number of bed days.

The task is solved by the fact that immediately after the operation, intravenous infusions of the complex drug Sorbilact of multifunctional action are used in the amount of 800.0 ml per day at a rate of 30 drops per minute for 5 days.

In cancer patients, in order to establish a clinical diagnosis, in addition to x-ray examination of the digestive tract, an endoscopic examination of the esophagus, stomach, and duodenum was performed using a fibrogastroscope and a fibroduodenoscope with tumor biopsy, as well as ultrasound and computer examination of the abdominal organs.

In order to establish the clinical effectiveness of the use of the infusion drug Sorbilact for the correction of hematological indicators of patients operated on for gastric cancer in the early postoperative period, two groups of oncological patients were examined with their distribution according to clinical diagnosis, gender and age (table 1).

Table 1

Distribution of cancer patients by clinical diagnosis, gender and age 11111111 | chi j chi zhichi| Zhu chi zhizhizhi about Rakshluuka.yi | 55 2 |2|1 4121/1117 |/12/18/5/|3

All cancer patients 55 |2|114|21|111|7/|1t12/8|5/|z

55 oncological patients with stomach cancer were under clinical observation. Age of patients: from 31 to 40 years - 3, from 41 to 50 years - b, from 51 to 60 years - 18, from 61 to 70 years - 20, from 71 to 80 years - 8 cancer patients (see table Mo1) .

The types and nature of surgical interventions are presented in Table 2.

Table 2

Operative interventions in gastric cancer patients who received infusions of Sorbilact (main group) and Ringer-Locke solution (comparison group)

Gastrectomy was performed in 55 oncological patients with stomach cancer. The method and volume of operations were determined depending on the localization, distribution and growth form of the malignant process detected before and during the operations.

The main group - 30 oncological patients with gastric cancer after gastrectomy surgery received infusion therapy using the drug Sorbilact in a dose of 800.0 ml per day at a rate of 30 drops per minute for 5 days in the early postoperative period.

The comparison group - 25 oncological patients with gastric cancer after gastrectomy surgery were treated with Ringer-Locke solution in a dose of 1000.0 ml per day.

The study of the effect of the infusion drug Sorbilact and Ringer-Locke's solution on the dynamics of the number of erythrocytes, hemoglobin content, leukocyte level, the number of segment-nuclear and rod-nuclear neutrophils, eosinophils, lymphocytes, monocytes and the rate of sedimentation of erythrocytes in the blood of operated patients was carried out before the start of infusion therapy in the first day after intravenous infusions, two days after intravenous injections, three days after intravenous infusions, four days after intravenous infusions, five days after intravenous infusions, and on the second day after the infusion therapy. Before the start of infusion therapy, in the first days after surgery, a decrease in the number of erythrocytes, hemoglobin content, an increase in the level of leukocytes, an increase in the number of rod-nuclear neutrophils, a decrease in lymphocytes and an acceleration of the sedimentation rate of erythrocytes in the blood of operated patients were found in both groups of cancer patients.

In oncological patients with stomach cancer, exhausted by the disease and related malnutrition and forced starvation, after total removal of the stomach develop

From a change in hematological indicators caused by operative stress, which leads to a significant decrease in the number of erythrocytes, the content of hemoglobin and lymphocytes in the blood of operated patients.

Repeated studies of hematological parameters on the second day after the infusion therapy with the use of the drug Sorbilact revealed that in the main group there was a normalization of the number of erythrocytes and the hemoglobin content in the blood of operated patients (table Mo

WITH).

Table C

The influence of the infusion drug Sorbilact (main group) and Ringer-Locke solution (comparison group) on the hematological indicators of patients operated on after gastrectomy in the early postoperative period (Mat)

Tetopolochn pokaonnkya one wine See not R ' Sorbilact p--30 Ringer-Locke p-25

Lymphocytes, 96 77777771 heads | "005

The normalization of the hemoglobin content is explained by the pronounced protein-sparing effect of the infusion drug Sorbilact. Hemoglobin in erythrocytes consists of globin - a protein with globin chains and heme molecules with iron atoms. Protein-preserving effect of the drug

Sorbilact is due to the high energy value of the infusion drug, the caloric content of which is 656 kcal (2736 kJ) per 800.0 ml.

In the comparison group, on the 6th day, the tendency towards normalization of the number of erythrocytes, hemoglobin content in the blood of the operated patients resumed, but it was significantly less than in the main group.

Normalization of hematological indicators occurred 9 days after the start of intravenous administration of Ringer-Locke solution.

An increase in the number of leukocytes, an increase in the number of rod-nuclear neutrophils, a decrease in lymphocytes, and an acceleration of the sedimentation rate of erythrocytes in the blood of operated patients were found in oncological patients with gastric cancer after gastrectomy in the early postoperative period.

Repeated studies of clinical blood analysis on the second day after the use of infusion therapy using the drug Sorbilact revealed that in the main group of operated patients there was a normalization of the number of leukocytes, the number of rod-nuclear neutrophils, lymphocytes and a decrease in the sedimentation rate of erythrocytes in the blood of cancer patients (see table 3).

In the comparison group, on the 6th day, the tendency towards normalization of the number of leukocytes, the number of rod-nuclear neutrophils, lymphocytes and a decrease in the sedimentation rate of erythrocytes resumed, but it was significantly less than in the main group. Normalization of hematological indicators occurred 9 days after the start of administration of Ringer-Lock solution.

Therefore, the use of infusion therapy in oncological patients with gastric cancer after gastrectomy surgery in the early postoperative period helps to accelerate the normalization of hematological indicators on the 6th day after surgical interventions in comparison with Ringer-Locke solution infusions.

The medicinal property of the infusion drug Sorbilact is due to detoxification,

With energetic, stimulating intestinal peristalsis action and correction of the acid-base state.

With the development of inflammatory edema of the esophageal-intestinal anastomosis, infusion therapy using Sorbilact prevents repeated surgical intervention and saves time for anti-inflammatory therapy.

In the case of functional insufficiency of the anastomosis of the esophagus and intestines, due to the anatomical and technical features of the operation in cancer patients, the use of the drug Sorbilact led to the restoration of the function of the anastomosis.

So, on the 6th day, after the infusion therapy with Sorbilact, a pronounced clinical effect is observed. In operated patients who underwent intravenous infusions of the drug Sorbilact earlier, the functions of the intestinal tract are restored, wounds heal faster, the number of postoperative complications decreases, patients with

From days they are discharged from the clinic.

In the comparison group, there was a trend toward improvement in clinical signs on day 6, but significantly less than in the main group. An oncological patient with gastric cancer developed signs of functional insufficiency of the anastomosis of the esophagus and intestine with separation of the sutures after gastrectomy. Two operated patients developed symptoms of anastomosis. In a cancer patient with stomach cancer, suppuration of the wound was observed after gastrectomy.

The obtained data confirm that the use of the multi-functional infusion drug Sorbilact in oncological patients with gastric cancer after gastrectomy in the early postoperative period has significant advantages over the known method of using the Ringer-Locke prototype solution, as there is an acceleration of the normalization of clinical signs and functional insufficiency of the esophageal anastomosis does not develop and intestines with suture separation, which shortens the length of stay of operated patients in inpatient treatment by 3 days.

A specific example of the use of the multi-functional infusion complex drug Sorbilact for the normalization of hematological parameters of a patient with gastric cancer after gastrectomy.

Min. 3., female, 56 years old, in order to establish a clinical diagnosis, in addition to an x-ray examination of the digestive tract, the patient underwent an endoscopic examination of the esophagus, stomach, duodenum using a fibrogastroscope and a fibroduodenoscope with a tumor biopsy, as well as an ultrasound and computer examination of the organs of the abdominal cavity , as a result of which a clinical diagnosis of stomach cancer was established. The oncology patient underwent a total gastrectomy. A clinical blood test in the first days after surgery revealed a decrease in the number of erythrocytes and hemoglobin content, an increase in the number of leukocytes, the number of rod-nuclear neutrophils, a decrease in lymphocytes and an acceleration of the sedimentation rate of erythrocytes.

Immediately after surgery, the oncology patient was prescribed intravenous drip administration of the complex multi-functional drug Sorbilact at a dose of 800.0 ml per day at a rate of drops per minute for 5 days.

Infusion therapy using the drug Sorbilact led to the normalization of the number of erythrocytes, the content of hemoglobin and lymphocytes, a decrease in the level of leukocytes, the number of rod-nuclear neutrophils and a decrease in the rate of sedimentation of erythrocytes in the blood of the operated patient.

From Intestinal motility resumed on the 2nd day after the operation. Wound healing in an oncology patient occurred with primary tension. The condition of the operated patient improved and she was discharged from the clinic in satisfactory condition 3 days earlier than in the comparison group.

Since, when using the multi-functional infusion complex drug Sorbilact, the length of stay of operated patients in inpatient treatment is shortened, thanks to the accelerated normalization of the number of erythrocytes, hemoglobin content, leukocyte level, the number of rod-nuclear neutrophils and blood lymphocytes, which improves the immediate results of surgical treatment and prevents the separation of sutures with the development of functional insufficiency of the esophageal-intestinal anastomosis, which confirms the essence of the task of a useful model.

Therefore, multiple intravenous administrations of the drug Sorbilact lead to the normalization of hematological parameters of operated patients and prevent the development of functional insufficiency of the esophageal-intestinal anastomosis with suture separation.

Infusion therapy using the drug Sorbilact has a positive clinical effect, which is expressed in the recovery of intestinal peristalsis before the end of the second day after surgery. Healing of postoperative wounds in cancer patients occurs by primary tension. In operated patients, there is no separation of the sutures of the anastomosis of the esophagus and intestine.

Therefore, the use of the multi-functional infusion complex drug Sorbilact to normalize the hematological parameters of gastric cancer patients after gastrectomy and to prevent the separation of sutures and the development of functional insufficiency of the esophagus and intestine anastomosis allows to reduce the duration of surgical treatment of oncological patients with gastric cancer after gastrectomy in the early postoperative period period, since the immediate results of surgical treatment are improved with the use of the drug Sorbilact, there is no separation of the anastomotic sutures and no functional insufficiency of the esophageal-intestinal anastomosis develops, which leads to a reduction in the length of stay of operated patients in the clinic on the 3rd day, which confirms the implementation of the task of a useful model.

The use of the multi-functional infusion complex drug Sorbilact is characterized by good tolerance and the absence of side effects, infusion therapy does not require expensive drugs, it is entirely based on the use of the domestic drug Sorbilact, which is available in sufficient quantities in pharmacies of Ukraine at an affordable price.

The use of the infusion drug Sorbilact is useful and necessary in medical practice for wide use in infusion therapy of operated patients in intensive care, abdominal, thoracic and surgical departments of clinics and hospitals.

Claims (1)

USEFUL MODEL FORMULA The use of the multi-functional infusion complex drug Sorbilact for the normalization of hematological parameters of gastric cancer patients after gastrectomy and with the aim of preventing the development of functional insufficiency of the esophageal-intestinal anastomosis, in which the drug is administered immediately after the operation in the form of intravenous drip infusions of 800 ml (10-12 ml per kg of body weight) per day at a rate of 30 drops per minute for 5 days.