UA141452U - DIET SUPPLEMENT - Google Patents

Abstract

Dietary supplement for oral administration in the form of an aqueous solution. Contains the following components: Component Quantity per 100 ml of aqueous solution Dextrose 20-67 g L-arginine 833-1667 mg Betaine 500-1167 mg L-carnitine 167-333 mg Ascorbic acid 33-100 mg Cocarboxylase 17-167 mg Coenzyme Q10 3-33 mg Cyanocobalamin 0.3-3 mcg Citric acid 167-1667 mg Sodium citrate 67-1333 mg Malic acid 33-667 mg and pharmaceutically acceptable excipients.

Description

The utility model belongs to the field of pharmaceuticals and relates to a dietary supplement for oral use.

Currently, a large number of dietary supplements are known. They are various vitamin, vitamin-mineral or herbal compositions, individually and/or in combination in the form of pills, tablets, powders, suspensions and solutions, taken orally with food or separately within the limits of physiological norms, for additional, compared with ordinary food, use of these substances.

Dietary supplements contain various substances or mixtures of substances, including proteins, carbohydrates, amino acids, edible oils, and extracts of plant and animal materials, which are considered necessary or beneficial for human nutrition and general health.

The basis of a useful model is the task of developing a dietary supplement for oral use, designed to normalize the body's metabolic processes, reduce the production of ketone bodies, accelerate their final oxidation and removal from the body, as well as normalize and restore liver function.

The task was solved with the help of dietary supplement "A-ketone" for oral use in the form of an aqueous solution, which contains the following components: ooocomponent of one solution

A component of an aqueous solution

Pharmaceutically acceptable excipients, such as flavorings, dyes, preservatives and other components, which are usually used in the preparation of pharmaceuticals, are also added to the dietary supplement.

The effect of the declared dietary supplement on the human body is due to the complex action of the active components included in its composition:

DEXTROSE (GLUCOSE) is a hexose monosugar according to its chemical structure. It is the main and indispensable source of energy for the body. Dextrose provides replenishment of energy expenditure, activates metabolic processes, improves the antitoxic function of the liver, increases the contractile activity of the myocardium, and expands blood vessels. Provides complete oxidation of ketone bodies and reverse development of acetonemic syndrome. It is used in food products, dietary supplements and medicines in its pure form in the form of anhydrous dextrose or monohydrate, as well as in combination with other substances.

II-CARNITINE is a derivative molecule of amino acids, according to its chemical structure it is beta-hydroxy-gamma-M-trimethylaminobutyric acid, a quaternary ammonium compound. And -carnitine is the only carrier of fatty acids through the mitochondrial membrane, where their complete oxidation occurs.

Only the levorotatory isomer (I-carnitine) has physiological activity, the dextrorotatory isomer (O-carnitine) is toxic to the body. It is used in dietary supplements and medicines for the prevention and treatment of its deficiency, to regulate metabolic processes in the body, namely to promote the complete oxidation of fatty acids, energy production, detoxification and providing cytoprotective action.

COENZYME 010 (UBIQUINONE) is a vitamin-like substance with a chemical structure of 1,4-benzoquinone. Ubiquinone is a key coenzyme in the processes of tissue respiration and energy generation during the oxidation of fats and carbohydrates in the mitochondria of every cell in the body. Helps improve energy metabolism, effectively neutralizes free radicals that can cause cell damage. It is used in dietary supplements as an additional source of coenzyme 010, as well as an antioxidant, an activator of metabolic processes in the body that ensure the function of tissue respiration and energy production.

COCARBOXYLASE (THIAMINE PYROPHOSPHATE) is an active form (coenzyme) of vitamin B, which is the main component of the carboxylase enzyme. Cocarboxylase improves the absorption of dextrose by the body (which is necessary for the oxidation of ketone bodies) and reduces acidosis, which is also always found in acetonemia. It is used in dietary supplements and medicinal products to regulate metabolic processes, enhance dextrose absorption and oxidation, detoxify the body, and reduce acidosis.

CYANOCOBALAMIN (VITAMIN Vig). Its active forms are coenzymes in two extremely important body reactions - methylation and isomerization. With the participation of vitamin B2 coenzyme, the amino acid methionine is formed from homocysteine, which is toxic to the body, which is later transformed into glutathione - the main intracellular antioxidant that provides protection and normal functioning of liver cells. In the isomerization reaction with the participation of the enzyme isomerase, the last stage of oxidation of fatty acids with an odd number of carbon atoms occurs, resulting in the formation of succinic acid, which is subsequently completely oxidized in the Krebs cycle. It is used in dietary supplements and medicines for prevention and treatment of deficiency of this vitamin, as well as for enhancing methylation and isomerization reactions, antioxidant protection and ensuring complete oxidation of fatty acids.

ASCORBIC ACID (VITAMIN C) is one of the main antioxidants of the body.

It prevents the peroxidation of fats, binds free radicals, limits inflammatory reactions and takes an active part in the body's immune defense mechanisms, increasing its resistance.

Activates the enzyme hexokinase, which contributes to the complete assimilation of dextrose, and therefore to the excretion of ketone bodies and the reduction of acetonemia. It is used in dietary supplements and medicines for the prevention and treatment of vitamin deficiency, as well as as an antioxidant and regulator of metabolic processes.

ARGININE is a conditionally irreplaceable amino acid, participates in the biosynthesis of proteins, removal and neutralization of ammonia, promotes the removal of terminal nitrogen, reduces the formation of free radicals harmful to liver cells, improves intracellular metabolism in hepatocytes, stimulates their activity, reduces hypoxia and inflammation, promotes regeneration of liver cells , which strengthens its detoxification function. Arginine is the main component in the synthesis of nitric oxide (NO), which has a vasodilating (vasodilator) effect, improves peripheral blood circulation, reduces oxygen starvation of various tissues, normalizes microcirculation in the liver, saturates it with oxygen. It is used in dietary supplements and medicines as a vasodilator, for

From the prevention and treatment of blood circulation and liver function disorders.

BETAINE is a lipotropic substance that participates in the synthesis of phospholipids, oxidation and utilization of fats, which contributes to their more complete oxidation. It has osmoprotective properties, protects cells, proteins and enzymes from the influence of environmental factors (viral infections, stress, intoxication). It is a direct donor of metal groups, participates in methionine metabolism in the liver, which improves fat metabolism, prevents and reduces steatosis (accumulation of fat in the liver). It has an anti-fibrotic, anti-inflammatory effect, reduces the concentration of homocysteine, thereby reducing the risk of thrombosis. Betaine helps to reduce general weakness and fatigue. It is used in dietary supplements to normalize metabolism, improve fat metabolism, and as a preventive measure for liver damage.

SODIUM CITRATE together with CITRIC ACID is a citrate buffer system that ensures stability of the pH of solutions against the influence of chemical compounds and environmental factors. In addition, citrate ions contribute to the digestion process, reduce dyspeptic manifestations that are frequent in acetonemic syndrome (nausea, heaviness in the stomach, flatulence). Citrate also reduces the acidosis (disruption of the acid-base state of the blood), which is always observed in acetonemic syndrome, since ketone bodies are acids in their chemical structure. Citric acid and sodium citrate are widely used in food products, dietary supplements and medicines.

MALATE (MALIC ACID) is also an organic acid that performs the function of correcting and stabilizing the pH of the solution. In addition, citrate together with manate are organic acids that take part in the cycle of tricarboxylic acids (Krebs), in which the complete oxidation of acetyl coenzyme-A (and therefore ketone bodies) to carbon dioxide and water occurs. In the case of a relative deficiency of dextrose (glucose), citrate and malate allow to support its function. Malate is also the "last" organic acid in the Krebs cycle, from which oxaloacetate is formed in the next reaction with the participation of the malate dehydrogenase enzyme. Oxidation of acetyl coenzyme-A (and therefore ketone bodies) begins precisely in the reaction of its interaction with oxaloacetate. Malic acid is widely used in food products, dietary supplements and medicines.

Preservatives that can be part of a dietary supplement are sodium benzoate, benzoic acid, potassium sorbate, methylparaben, ethylparaben or propylparaben. They are typical preservatives that prevent microbial contamination and allow the product to maintain its stated shelf life.

In a preferred embodiment of the utility model, the dietary supplement contains the following components:

Sodium benzoate 17-333 mg or benzoic acid, 14-282 mg or potassium sorbate, 8-200 mg or methylparaben, 4-200 mg or ethylparaben, 4-200 mg or propylparaben 2-100 mg

A dietary supplement can be made as follows.

Stages of the manufacturing process of DD A-KETONE. 1. Obtaining a solution for packaging. 1.1. Preparation of dextrose solution.

Dextrose is dissolved in the prepared water in the reactor, stirred until the dextrose is completely dissolved and a clear solution is obtained. 1.2. Preparation of solution for packaging.

The calculated amount of all other components is added to the dextrose solution in the reactor:

And - arginine; sodium benzoate or benzoic acid, or potassium sorbate, or methylparaben, or ethylparaben, or propylparaben;

And -carnitine; cyanocobalamin; ascorbic acid; cocarboxylase; coenzyme 010; malic acid; sodium citrate.

The solution is mixed with a stirrer until the components are completely dissolved.

The mixer is turned off and the pH of the solution is checked: if the pH does not correspond to the standard, adjust with citric acid or sodium citrate.

Bring the volume of the solution to the mark with prepared (distilled) water. They stir

The resulting solution is mixed with a stirrer. 2. Filtration of the solution.

The resulting solution is filtered through a filter.

C. Packaging of the solution

Containers/vials/vials are filled with the required volume using a liquid dispenser.

Filled containers/vials/vials are transferred to packaging.

Claims (3)

USEFUL MODEL FORMULA 1. Dietary supplement for oral use in the form of an aqueous solution, which is distinguished by the fact that it contains the following components: oo component | odkoyurocin, a component of an aqueous solution and pharmaceutically acceptable excipients. 2. Dietary supplement according to claim 1, which is characterized by the fact that it contains flavorings, dyes and preservatives as pharmaceutically acceptable excipients. 3. Dietary supplement according to claim 1 or 2, which differs in that it contains the following components: or benzoic acid, 14-282 mg or potassium sorbate, 8-200 mg or methylparaben, 4-200 mg or ethylparaben, 4-200 mg or propylparaben 2-100 mg