UA138329U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

A method for predicting the development of osteoarthritis, including clinical examination, radiography. Additionally, in the patient's serum determine the polymorphism of the nitric oxide synthase gene (eNOS T786C), the content of thrombomodulin, folic acid, cobalamin and homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid <300 ng / ml ng / ml predict the development of osteoarthritis.

Description

A useful model belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in the diagnosis of the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, examination of biopsies of the synovial membrane, synovial fluid, cartilage biopsy TSA.N.

Okorokov Diagnosis of diseases of internal organs. - M., 2001. - T.2. - pp. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, the polymorphism of the nitric oxide synthase gene (6eMOb5 17860), the content of thrombomodulin, folic acid, cobalamin and, in the case of homozygous carrier 786-SS, thrombomodulin levels »5 ng/ml are determined in the patient's blood serum , folic acid "b ng/ml, cobalamin "300 ng/ml predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, X-rays are taken, the EMO5 T786C gene polymorphism, thrombomodulin, folic acid, and cobalamin content are determined by the immunoenzymatic method. With homozygous carrier 786-SS and levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, cobalamin "300 ng/ml predict the development of osteoarthritis.

A specific example of using the method.

Patient U., 63 years old, was hospitalized in the clinic due to pain syndrome of the left hip joint. Examined, X-ray taken. No signs of osteoarthritis were found. The eMO5 1786C gene polymorphism and the content of thrombomodulin, folic acid, and cobalamin were determined in the blood serum using the immunoenzymatic method. A homozygous carrier of 786-SS was established, the levels of thrombomodulin - 15 ng/ml, folic acid 2.6 ng/ml, cobalamin - 240 ng/ml.

The development of osteoarthritis was diagnosed. After 12 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

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Claims (1)

USEFUL MODEL FORMULA The method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of the nitric oxide synthase gene (EMO5 T786C), the content of thrombomodulin, folic acid, cobalamin, and with homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml are additionally determined in the patient's blood serum ml, cobalamin "300 ng/ml predict the development of osteoarthritis.