UA138611U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes clinical examination, radiography. Additionally, polymorphism of the nitric oxide synthase gene (eNOS T786C), thrombomodulin, folic acid, glycosaminoglycans (GAG), interleukin 6 (IL-6), and homocysteine are determined in the patient's serum. With a homozygous carrier of 786-CC, levels of thrombomodulin> 5 ng / ml, folic acid <6 ng / ml, GAG> 28 μmol / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l predict the development of osteoarthritis.

Description

The proposed useful model The method of predicting the development of osteoarthritis belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in diagnosing the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (Okorokov

A.N. Diagnosis of diseases of internal organs. - M., 2001. - T. 2. - b. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, the polymorphism of the nitric oxide synthase gene (6eMOb5 17860), the content of thrombomodulin, folic acid, glycosaminoglycans (GAG), interleukin 6 (IL-b6), homocysteine and homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, GAG "28 μmol/l, IL-b6 "10 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, x-rays are taken, the eMO5 1786C gene polymorphism is determined, the content of thrombomodulin, folic acid, GAG, IL-b6, and homocysteine is determined by the immunoenzymatic method. With homozygous carrier 786-SS and levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, GAG "28 μmol/l, IL-b "10 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.

A specific example of using the method

Patient B., 65 years old, was hospitalized in the clinic due to pain syndrome in the right knee joint. Examined, x-ray taken. No signs of osteoarthritis were found. The eMO5 1786C gene polymorphism and the content of thrombomodulin, folic acid, GAG, IL-6, and homocysteine were determined in the serum. A homozygous carrier of 786-SS was established, the levels of thrombomodulin - 15 ng/ml, folic acid - 3.4 ng/ml, GAG - 43 μmol/l, IL-6-22 ng/l, homocysteine - 35 μmol/l. The development of osteoarthritis was diagnosed. After 11 months on

X-rays revealed the phenomena of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

Claims (1)

USEFUL MODEL FORMULA The method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of the nitric oxide synthase gene (eMO5 17860), the content of thrombomodulin, folic acid, glycosaminoglycans (GAG), interleukin 6 (IL-6) is additionally determined in the patient's blood serum , homocysteine and with homozygous carrier 786- SS, levels of thrombomodulin 25 ng/ml, folic acid "6 ng/ml, GAG" 28 μmol/l, IL-6 210 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.