UA137609U - METHOD OF DETERMINING THE INFLUENCE OF RADIATION OF BLOOD BY RADIATION RADIATION ON BLOOD OXYGENATION - Google Patents

Abstract

The method of determining the effect of irradiation of blood with radiation on blood oxygenation includes determining the values of oxygen saturation of arterial and mixed venous blood, followed by calculation of the oxygen utilization factor. At the same time the blood is affected by radiation.

Description

The utility model belongs to the field of medicine, namely to laboratory methods for determining hemoglobin.

There is a well-known method of measuring the percentage oxygen saturation of mixed venous blood (ZMO?g by the method of reflection spectrophotometry. The research is carried out by ip mimo (Intensive therapy", precl. from English - M: GEOTAR Medicine, 1998. - p. 118). The method consists in that the light through the catheter located in the pulmonary artery is directed directly into the bloodstream. After reflecting off the hemoglobin, it returns back. The catheter is connected to a photodetector that measures the intensity of the reflected light beam. With the help of the method, it is possible to continuously monitor the level of oxygen saturation of the mixed venous blood (Vigtap N., Nad A., Nem E.,

Aretap A. /Sopiipoi5 topiyugipd oi tikhed mepoi5 ohudep zaishgayop ip Netoadipatisau ipetabiye rayepib5. - Spevy 1984. - Mo. 6. - R.753-756|Y. However, the task of this method does not include determining the degree of utilization of oxygen by body tissues.

There is a known method of determining the degree of utilization of oxygen by body tissues (Intensive therapy /Sub. ed. V.D. Malysheva. - M.: Medicine, 2002. - P. 81-82)|), which includes determination of oxygen saturation and tension in arterial and mixed venous blood by the micro-Astrup method.

To carry out the method, the doctor's hands and the patient's skin are disinfected at the place of the intended puncture of the artery, then the artery is punctured with a syringe, in which 0.1 ml of official heparin solution or an appropriate amount of dry heparin is previously filled. 1.0 ml of blood is taken. The blood collected in the syringe is injected into the device, which works according to the micro-Astrup method, which automatically, after preliminary calibration, calculates the oxygen tension in the arterial blood sample and the degree of its saturation with oxygen. The same indicators are determined in the same way in a sample of mixed venous blood. At least 5 minutes pass from the moment of puncturing the blood vessel to receiving the results of each analysis. To obtain data on the dynamics of these indicators, repeated samples are required.

The disadvantage of the known method is its complexity and time-consuming nature. Constant repeated blood sampling is required, which leads to excessive traumatization of blood vessels and blood loss. The results obtained using this method are not absolutely accurate. This is due to the need to add heparin to each sample. In addition, there is a decrease in blood oxygen saturation during its transportation and analysis.

З A known method of determining the degree of utilization of oxygen by body tissues (Patent for the invention

КИ Mo 2241378 IPC AbЕ1В 5/145), which is the closest analogue of the developed useful model, which includes determining the value of oxygen saturation of arterial and mixed venous blood with subsequent calculation of the oxygen utilization coefficient, while carrying out simultaneous measurement of the value of oxygen saturation of arterial and mixed venous blood. However, this method does not allow determining the effect of radiation exposure of blood on blood oxygenation.

The basis of a useful model is the task of determining the effect of radiation exposure of blood on blood oxygenation.

The task is solved by the fact that in the method of determining the effect of radiation exposure of blood on blood oxygenation, which includes determining the oxygen saturation of arterial and mixed venous blood with subsequent calculation of the oxygen utilization coefficient, according to a useful model, the blood is simultaneously affected by radiation radiation.

The essence of a useful model is as follows.

Oximetric systems are calibrated before introduction, according to the instructions. Catheterization of the femoral artery, which has the largest internal diameter, is performed with a catheter equipped with a fiber optic sensor. Catheterization of the pulmonary artery is carried out with a catheter with a fiber-optic sensor. Both catheters are connected to photodetectors that measure the intensity of the reflected light beam, which is directed directly into the bloodstream through the catheters.

At the same time, human tissue is affected by radiation. On the screens of the devices, the values of oxygen saturation are displayed, respectively, of arterial (circular venous blood. (ro)

It is necessary to calculate the dependence of oxygen content in the blood az , oxygen delivery 27, oxygen consumption in tissues (MO,) and utilization coefficient (CFU,) on hemoglobin concentration. y sddist Net rovi OZ in the following way: 2. Oxygen, which is in the blood, in the process of circulation is carried to all organs and tissues of the body, where its utilization takes place depending on the metabolic need. The total number of cysts that penetrate the tissues of the body is determined from the formula:

3. Oxygen consumption by tissues is determined by the difference between the delivery of oxygen by arterial blood and saturated oxygen by mixed venous blood:

4. Part of the total amount of oxygen is utilized to ensure the metabolic processes of tissues and organs. the rate of utilization is calculated from the formula: in fabrics and omns, the rate of utilization is the calculation form of

Nh. hemoglobin content in blood, ZRO". saturation of oxyhemoglobin in arterial blood, ras, - partial pressure of oxygen in arterial blood, 1.38 - Huffner coefficient, 0.0031 - Runzen coefficient (amount of oxygen in ml that is dissolved in plasma of 100 ml of blood), so. cardiac output,

Uchg - oxygen saturation of mixed venous blood (this is considered blood from the pulmonary artery.

The oxygen saturation of arterial and mixed venous blood and the oxygen utilization rate are monitored. If necessary, cardiac output is measured by the thermodilution method (Intensive therapy / Sub-ed. V.D. Malysheva. - M.: Medicine, 2002. - P. 175-185).

The obtained value of the oxygen utilization coefficient is compared with normal values. its deviation beyond normal values allows judging the nature and severity of oxygen absorption disorders by tissues during radiation exposure to tissues and carrying out their targeted correction. In addition, the simultaneous analysis of values of oxygen saturation of arterial and mixed venous blood, the coefficient of oxygen utilization and cardiac output allows monitoring the state of the body's oxygen budget. Evaluation of these indicators and their interrelation makes it possible to control the effect of all components of radiation therapy.

The use of a useful model allows for constant monitoring of the saturation level of both arterial and mixed venous blood and monitoring of the oxygen utilization rate by body tissues under the influence of radiation.

This makes it possible to make a timely correction of the parameters of the oxygen status. At the same time, accurate research results are obtained in a short period of time. The procedure of observing the dynamics of the studied parameters can be carried out for a long time.

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Claims (1)

USEFUL MODEL FORMULA A method of determining the effect of radiation exposure of blood on blood oxygenation, which includes determination of oxygen saturation values of arterial and mixed venous blood with subsequent calculation of the oxygen utilization coefficient, which is characterized by the fact that the blood is simultaneously affected by radiation radiation.