UA137608U - METHOD FOR DETERMINING THE INFLUENCE OF BLOOD IRRADIATION BY ELECTROMAGNETIC RADIATION ON BLOOD OXYGENATION - Google Patents

Abstract

The method of determining the effect of irradiation of blood with electromagnetic radiation on blood oxygenation includes determining the amount of oxygen saturation of arterial and mixed venous blood, followed by calculation of the oxygen utilization factor. At the same time the blood is affected by electromagnetic radiation.

Description

The utility model belongs to the field of medicine, namely to laboratory methods for determining hemoglobin.

There is a well-known method of measuring the percentage oxygen saturation of mixed venous blood (ZmMOg by the method of reflection spectrophotometry. The research is carried out by ip mimo (Intensive therapy", precl. from English, M., GEOTAR Medicine, 1998, p. 118). The method consists in the fact that light through a catheter located in the pulmonary artery, it is directed directly into the bloodstream. Reflecting from hemoglobin, it returns back. The catheter is connected to a photodetector, which measures the intensity of the reflected light beam. Using the method, it is possible to continuously monitor the level of oxygen saturation of mixed venous blood Ivigtap N., Nad A., Nem E.,

Aretap A. / Sopiipoi5 topiyugipd oi tikhed mepoi5 ohudep zaishgayop ip Netoadipatisau ipetabie raiiyepibe. Spevy 1984; Mo 6; R. 753-756). However, the task of this method does not include determining the degree of utilization of oxygen by body tissues.

A known method is a method for determining the degree of utilization of oxygen by body tissues (Intensive therapy / Sub-ed. V.D. Malysheva, M., Medicine, 2002, p. 81-82), which includes determination of oxygen saturation and tension in arterial and mixed venous blood according to the micro-Astrup method.

To carry out the method, the doctor's hands and the patient's skin are disinfected at the place of the intended puncture of the artery, then the artery is punctured with a syringe, in which 0.1 ml of official heparin solution or an appropriate amount of dry heparin is previously filled. 1.0 ml of blood is taken. The blood collected in the syringe is injected into the device, which works according to the micro-Astrup method, which automatically, after preliminary calibration, calculates the oxygen tension in the arterial blood sample and the degree of its oxygen saturation. The same indicators are determined in the same way in a sample of mixed venous blood. At least 5 minutes pass from the moment of puncturing the blood vessel to receiving the results of each analysis. To obtain data on the dynamics of these indicators, repeated samples are required.

The disadvantage of the known method is its complexity and time-consuming nature. Constant repeated blood sampling is required, which leads to excessive traumatization of blood vessels and blood loss. The results obtained using this method are not absolutely accurate. This is due to the need to add heparin to each sample. In addition, there is a decrease in blood oxygen saturation during its transportation and analysis.

З A known method of determining the degree of utilization of oxygen by body tissues (Patent for the invention

КИ 2241378 Ab185/145), which is the closest analogue of the developed useful model, which includes determining the value of oxygen saturation of arterial and mixed venous blood with subsequent calculation of the oxygen utilization coefficient, while carrying out simultaneous measurement of the value of oxygen saturation of arterial and mixed venous blood. However, this method does not allow determining the effect of electromagnetic radiation on blood oxygenation.

The basis of a useful model is the possibility of determining the effect of electromagnetic radiation on blood oxygenation.

The problem, which is the basis of a useful model, is solved due to the fact that the method of determining the effect of electromagnetic radiation exposure of blood on blood oxygenation, which includes determining the oxygen saturation of arterial and mixed venous blood with subsequent calculation of the oxygen utilization coefficient, in accordance with the useful model at the same time the blood is affected by electromagnetic radiation.

The essence of a useful model is as follows. Oximetric systems are calibrated according to the instructions before administration. Catheterization of the femoral artery, which has the largest internal diameter, is performed with a catheter equipped with a fiber optic sensor. Catheterization of a person's pulmonary artery with a catheter with a fiber-optic sensor. Both catheters are connected to photodetectors that measure the intensity of the reflected light beam, which is directed directly into the bloodstream through the catheters. At the same time, human tissue is affected by electromagnetic radiation. The oxygen saturation values of arterial and mixed venous blood, respectively, are displayed on the screens of the devices.

It is necessary to calculate the dependence of the content of oxygen in the blood (CaOg), oxygen delivery (0Oz), oxygen consumption in tissues (MOg) and utilization coefficient (CFU") on hemoglobin concentration. vv BE UVO Vau lny way; 2. Oxygen found in the blood during circulation is carried to all organs and tissues of the body, where it is utilized depending on the metabolic need. The total amount of energy that is given to the tissues of the body is determined from the formula:

3. Oxygen consumption by tissues is determined by the difference between the delivery of oxygen by arterial blood and the saturation of mixed venous blood: ус, ТЗ SOНО(Вро, У, 4. A part of the total amount of oxygen is utilized to ensure the metabolic processes of tissues and the efficiency of utilization is calculated from formulas:

In Gorgan's tkdduus, the utilization coefficient is the calculated form of ro,

Nh. hemoglobin content in of blood, zro". saturation of oxyhemoglobin in arterial blood,

Rao, partial pressure of oxygen in arterial blood, 1.38 - Guffner's coefficient, 0.0031 - Bunsen's coefficient (amount of oxygen in ml, which is dissolved in plasma of 100 ml of blood), so. cardiac output, MU - oxygen saturation of mixed venous blood (this is considered blood from the pulmonary artery.

The oxygen saturation of arterial and mixed venous blood and the oxygen utilization rate are monitored. If necessary, cardiac output is measured by the thermodilution method (Intensive therapy / Lod. ed. V.D. Malysheva, M., Medicine, 2002, pp. 175-185).

The obtained value of the oxygen utilization coefficient is compared with normal values. its deviation beyond normal values allows judging the nature and severity of oxygen absorption disorders by tissues during electromagnetic influence on tissues and carrying out their purposeful correction. In addition, the simultaneous analysis of values of oxygen saturation of arterial and mixed venous blood, the coefficient of oxygen utilization and cardiac output allows monitoring the state of the body's oxygen budget. The assessment of these indicators and their interrelation makes it possible to control the effect of all components of conducting electromagnetic therapy.

The use of a useful model allows for constant monitoring of the level of saturation of both arterial and mixed venous blood and monitoring of the oxygen utilization rate by body tissues under the influence of electromagnetic radiation.

This makes it possible to make a timely correction of the parameters of the oxygen status. At the same time, accurate research results are obtained in a short period of time. The procedure of observing the dynamics of the studied parameters can be carried out for a long time

From time

Claims (1)

USEFUL MODEL FORMULA A method of determining the effect of electromagnetic radiation exposure of blood on blood oxygenation, which includes determination of the oxygen saturation of arterial and mixed venous blood followed by calculation of the oxygen utilization coefficient, which is characterized by the fact that the blood is simultaneously affected by electromagnetic radiation.