UA131171U - METHOD OF FORECASTING OSTEOARTHrosis DEVELOPMENT - Google Patents

Abstract

A method for predicting the development of osteoarthritis includes clinical examination, radiography, Additionally, serum polymorphism of methylenetetrahydrofolate reductase (MTHFR C677T), glycosaminoglycans (GAG) content, interleukin 6 (IL-6), homo-cysteine, is determined. With homozygous carrier 677-TT and levels of GAG> 28 μmol / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l predict the development of osteoarthritis.

Description

The proposed method of predicting the development of osteoarthritis belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in diagnosing the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include radiography, examination of a biopsy of the synovial membrane, synovial fluid, a biopsy of cartilage (Okorokov

A.N. Diagnosis of diseases of internal organs. - M., 2001. - Vol. 2. - P. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEK C677T), the content of glycosaminoglycans, interleukin 6 (IL-b), homocysteine is determined in the patient's blood serum, and in case of homozygous carrier 677-

TT, HAG content »28 μmol/l, IL-6 »10 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, X-rays are taken, and the MTNEK S677T gene polymorphism is determined. The GAG content is determined by the immunoenzymatic method,

IL-6, homocysteine. With homozygous carrier 677-TT, levels of GAG »28 μmol/l, IL-6 210 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.

A specific example of using the method

Patient R., 59 years old, was hospitalized in the clinic due to pain in the left hip joint. Examined, x-ray taken. No signs of osteoarthritis were found. The MTNEK C677T gene polymorphism was determined in blood serum. The content of GAG, IL-6, and homocysteine was determined by the immunoenzymatic method. Homozygous carrier 677-1TT was established. GAG levels - 42 μmol/l, IL-6-22 ng/l, homocysteine - 31 μmol/l. The development of osteoarthritis was diagnosed.

After 14 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

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Claims (1)

USEFUL MODEL FORMULA A method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEV C677T), the content of glycosaminoglycans (GAG), interleukin 6 (IL-6), homocysteine, and with homozygous carrier 677-171 and levels of GAG »28 μmol/l, IL-6 »10 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.